D:Mouth Ulcer

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Disease Term
Synonyms Mouth Ulceration, Mouth Ulcers, Oral Ulcer, Oral Ulceration, ORAL ULCERS, Ulcer Mouth, Ulcer Of Mouth Disorder, ULCER OF ORAL MUCOSA, Ulcer Oral, Ulceration Of Oral Mucosa, Ulcers Mouth
Documents 206
Hot Single Events 28
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Mouth Ulcer. They are ordered first by their relevance to Mouth Ulcer and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT311046 Binding of CSF2 and IL33 1 0.00 1.86 0.26 100.00
2 INT285399 Binding of DEFB1 and HLA-B 1 0.01 1.33 0 91.40
3 INT101942 Binding of CD40 and CD40LG 16 0.23 15.24 4.01 46.08
4 INT194644 Tlr4 Positive_regulation of TNF 6 0.58 2.42 0.76 5.00
5 INT285746 IL6 Regulation of Localization of PRL 1 0.08 1.51 0.39 5.00
6 INT285749 IL6 Positive_regulation of Localization of PRL 1 0.08 1.51 0.39 5.00
7 INT285750 IL1B Positive_regulation of Localization of PRL 1 0.05 1.51 0.39 5.00
8 INT285744 IL1B Regulation of Localization of PRL 1 0.05 1.51 0.39 5.00
9 INT194641 Binding of IL10 and TNF 2 0.14 1.09 0.35 5.00
10 INT285748 PRL Positive_regulation of Positive_regulation of C6orf25 1 0.01 1.01 0.31 5.00
11 INT174658 TNF Positive_regulation of Gene_expression of ITGAM 1 0.16 1.54 0.3 5.00
12 INT174657 IL8 Positive_regulation of Gene_expression of LTBR 1 0.01 1.53 0.3 5.00
13 INT174659 TNF Positive_regulation of Gene_expression of LTBR 1 0.22 1.54 0.3 5.00
14 INT285745 IL31RA Positive_regulation of Gene_expression of MPL 1 0.19 1.04 0.22 5.00
15 INT325056 Binding of E2f1 and Ang 1 0.06 1.3 0.12 5.00
16 INT325057 Binding of Hand1 and Ang 1 0.01 1.29 0.12 5.00
17 INT306452 Binding of MBL2 and TLR4 1 0.38 0.37 0.1 5.00
18 INT306453 MBL2 Regulation of Binding of TLR4 1 0.48 0.37 0.1 5.00
19 INT325059 Insr Positive_regulation of Ang 1 0.02 1.4 0.08 5.00
20 INT325058 Igf1 Positive_regulation of Ang 1 0.04 1.4 0.08 5.00
21 INT325060 Binding of Insr and Hand1 1 0.00 0.16 0.05 5.00
22 INT194642 IL10 Positive_regulation of TNF 1 0.18 0.22 0.04 5.00
23 INT194645 Negative_regulation of Tlr4 Positive_regulation of TNF 1 0.01 0.27 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Mouth Ulcer. They are ordered first by their pain relevance and then by number of times they were reported in Mouth Ulcer. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT203896 Binding of Impact 3 0.10 1.47 0.49 99.76
2 INT174903 Binding of IMPACT 3 0.32 2.12 0.49 99.76
3 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 99.38
4 INT81688 Binding of ras 32 0.41 30.13 4.02 99.08
5 INT12844 Binding of TP63 15 0.47 10.57 3.38 99.08
6 INT51264 Positive_regulation of TXK 21 0.54 10.69 1.1 99.02
7 INT28714 Negative_regulation of Csf3 10 0.41 6.9 1.6 97.96
8 INT61624 Positive_regulation of Gene_expression of IL12A 50 0.56 33.07 13.07 97.22
9 INT95565 Positive_regulation of IL12A 47 0.56 33.96 10.16 97.22
10 INT61619 Gene_expression of IL12A 194 0.77 146.07 41.97 97.02
11 INT4004 Gene_expression of IGHG3 321 0.71 221.03 42.33 96.84
12 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 96.60
13 INT2120 Gene_expression of CD79A 159 0.78 111.69 17.16 96.24
14 INT148420 Binding of DEFB1 3 0.36 3.81 0.48 96.08
15 INT712 Positive_regulation of LDHA 160 0.70 175.25 19.11 93.68
16 INT4114 Gene_expression of Srf 9 0.70 6.11 2.63 93.60
17 INT143569 Binding of Srl 1 0.33 0.92 0.09 92.20
18 INT6481 Binding of TNF 624 0.48 510.2 214.82 91.88
19 INT35242 Negative_regulation of MBL2 17 0.48 12.53 1.73 89.20
20 INT37390 Regulation of Crp 39 0.46 28.74 11.45 88.96
21 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 87.60
22 INT156975 Gene_expression of SLEB1 31 0.65 38.83 6.73 85.04
23 INT23246 Gene_expression of HLA-DRB4 37 0.64 36.79 6.61 82.40
24 INT48626 Positive_regulation of Csf3 33 0.66 29.79 7.34 82.04
25 INT21609 Positive_regulation of RASGRP1 58 0.50 40.78 5.47 81.96
26 INT134952 Localization of DSG3 3 0.81 3.23 0.16 81.56
27 INT67822 Binding of SERPINH1 17 0.36 19.05 7.24 81.40
28 INT13520 Binding of HLA-DRB4 30 0.42 32.65 6.74 80.48
29 INT167056 Gene_expression of CALR 29 0.75 20.05 1.25 78.80
30 INT18010 Positive_regulation of CD40LG 122 0.70 100.8 18.46 78.44
31 INT1878 Binding of HLA-B 440 0.48 321.16 127.36 77.36
32 INT10147 Gene_expression of Serpinc1 28 0.76 17.73 5.77 76.92
33 INT749 Gene_expression of HLA-B 341 0.75 224.12 77.37 75.84
34 INT91703 Negative_regulation of Myoz1 78 0.58 53.78 13.5 75.76
35 INT573 Negative_regulation of C3 60 0.59 41.37 7.78 75.68
36 INT19399 Gene_expression of Rf 43 0.36 33.39 13.53 75.48
37 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 75.00
38 INT28872 Positive_regulation of CSRP1 49 0.70 47.23 11.7 75.00
39 INT254724 Negative_regulation of DHFR 2 0.42 3.92 1.39 73.84
40 INT23402 Binding of HLA-DOA 74 0.48 52.01 10.89 72.24
41 INT287525 Localization of CAV2 5 0.47 5.32 2 71.92
42 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 68.68
43 INT19929 Negative_regulation of Positive_regulation of TNF 52 0.59 38.16 16.51 68.68
44 INT250281 Positive_regulation of Positive_regulation of CD40LG 3 0.23 3.19 0.73 68.52
45 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 68.20
46 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 68.20
47 INT109849 Negative_regulation of CRAMP1L 2 0.08 1.05 0.3 67.44
48 INT151878 Gene_expression of CAV2 18 0.66 9.26 2.17 67.20
49 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 67.12
50 INT325047 Gene_expression of Hand1 1 0.07 6.42 1.06 66.64
51 INT24926 Regulation of Csf3 17 0.52 10.41 3.04 66.08
52 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 66.00
53 INT36287 Binding of CD4 96 0.47 58.93 11.88 64.72
54 INT7206 Binding of HBG1 14 0.47 3.44 2.14 64.72
55 INT4137 Positive_regulation of C3 73 0.69 48.57 12.63 64.36
56 INT12265 Positive_regulation of IgG 168 0.63 104.89 19.76 62.88
57 INT301991 Positive_regulation of Hn1 1 0.06 1.09 0.09 62.68
58 INT4420 Positive_regulation of GOT1 103 0.64 88.4 18.38 60.96
59 INT163114 Positive_regulation of Gene_expression of GOT1 7 0.24 8.93 0.5 60.96
60 INT4419 Gene_expression of GOT1 20 0.65 22.53 2.53 60.60
61 INT725 Negative_regulation of IgG 62 0.41 37.21 8.16 58.68
62 INT13354 Transcription of TNF 108 0.72 85.81 42.32 58.32
63 INT1123 Positive_regulation of CD79A 74 0.70 51.96 7.14 56.08
64 INT1125 Positive_regulation of IGHG3 130 0.69 112.07 13.18 55.68
65 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 55.12
66 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86 55.12
67 INT21687 Positive_regulation of ras 143 0.58 97.34 27.31 54.68
68 INT109658 Gene_expression of IL1RAPL1 3 0.67 1.8 0.87 54.64
69 INT285754 Gene_expression of MPL 1 0.22 2.05 0.21 54.28
70 INT55812 Positive_regulation of LOC259246 2 0.03 1.87 0.09 53.64
71 INT15419 Gene_expression of IL31RA 6 0.65 5.02 1.19 53.12
72 INT8483 Positive_regulation of Positive_regulation of TNF 73 0.67 60.35 22.03 51.52
73 INT2129 Positive_regulation of F2 83 0.70 58.95 12.63 48.72
74 INT162372 Positive_regulation of SFTPD 15 0.67 11.8 3.21 48.44
75 INT336900 Positive_regulation of Sftpd 1 0.01 1.39 0.03 48.44
76 INT132161 Gene_expression of MTX1 48 0.58 26.55 32.32 47.52
77 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 45.88
78 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 44.00
79 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 43.68
80 INT11340 Positive_regulation of SLC17A5 120 0.67 113.52 14.5 43.68
81 INT756 Gene_expression of C3 138 0.75 100.6 19.2 41.72
82 INT6596 Positive_regulation of HLA-DRB1 33 0.61 27.01 7.26 41.28
83 INT9951 Gene_expression of ANGPTL5 45 0.53 37.2 6.44 41.20
84 INT12324 Positive_regulation of PRTN3 26 0.70 18.82 4.55 41.04
85 INT3060 Negative_regulation of Bche 94 0.59 46.75 18.51 40.48
86 INT17551 Positive_regulation of Gene_expression of HLA-DRA 31 0.70 15.39 6 40.44
87 INT16364 Gene_expression of HLA-DRA 234 0.78 118.81 45.01 40.04
88 INT9660 Regulation of TNF 363 0.62 312.94 139.99 39.84
89 INT97308 Gene_expression of TPO 15 0.65 13.26 2.12 39.40
90 INT701 Localization of IGHE 87 0.80 40.5 10.62 38.00
91 INT72747 Localization of IgG 55 0.53 30.88 4.19 38.00
92 INT55698 Regulation of Binding of TNF 13 0.44 8.98 4.74 33.56
93 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 29.60
94 INT179542 Positive_regulation of C3 27 0.52 19.39 3.83 28.24
95 INT247102 Binding of MBL2 16 0.38 14.18 1.54 21.12
96 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87 19.48
97 INT1118 Gene_expression of C6orf25 73 0.77 47.24 9.1 13.68
98 INT69157 Gene_expression of IL5 127 0.77 102.58 26.81 13.28
99 INT142162 Binding of IL10 30 0.37 21.9 4.84 10.80
100 INT73497 Regulation of IL10 33 0.45 22.6 9.19 9.60
101 INT65713 Localization of ICAM1 42 0.81 39.55 11.49 8.76
102 INT16404 Regulation of CD4 54 0.61 33.05 10.29 8.08
103 INT35164 Negative_regulation of IGHE 96 0.58 76.3 9.74 5.92
104 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
105 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
106 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
107 INT22548 Positive_regulation of Casp3 483 0.70 258.78 213.07 5.00
108 INT94952 Positive_regulation of Mapk14 305 0.70 197.83 186.61 5.00
109 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 5.00
110 INT49134 Gene_expression of Grin1 270 0.78 84.78 148.61 5.00
111 INT425 Localization of PRL 455 0.81 189.64 144.8 5.00
112 INT7533 Gene_expression of Tlr4 720 0.78 343.22 121.57 5.00
113 INT7341 Positive_regulation of Grin1 169 0.70 65.86 118.38 5.00
114 INT12082 Localization of IL6 365 0.81 241.78 105.78 5.00
115 INT915 Positive_regulation of PRL 342 0.70 141.96 104.31 5.00
116 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 5.00
117 INT82878 Gene_expression of Ccl2 201 0.78 164.95 101.35 5.00
118 INT5610 Positive_regulation of Insr 140 0.69 37.26 86.24 5.00
119 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92 5.00
120 INT170332 Gene_expression of IFN1@ 477 0.75 275.21 69.65 5.00
121 INT6849 Localization of IL1B 229 0.81 112.56 69.63 5.00
122 INT253 Regulation of PRL 184 0.62 47.27 65.79 5.00
123 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 5.00
124 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 5.00
125 INT7340 Regulation of Grin1 87 0.62 30.37 57.93 5.00
126 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 5.00
127 INT1579 Gene_expression of PRL 279 0.78 119.2 55.41 5.00
128 INT17915 Gene_expression of Insr 141 0.75 47.45 48.59 5.00
129 INT57021 Positive_regulation of Gene_expression of Grin1 62 0.70 24.77 47.31 5.00
130 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 5.00
131 INT73502 Positive_regulation of IL10 154 0.69 124.87 43.5 5.00
132 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 5.00
133 INT918 Positive_regulation of Localization of PRL 90 0.70 23.97 40.3 5.00
134 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 5.00
135 INT88322 Gene_expression of CCR5 111 0.78 77.36 39.84 5.00
136 INT916 Regulation of Localization of PRL 92 0.62 22.98 38.13 5.00
137 INT11439 Positive_regulation of Csf2 105 0.69 62.63 37.77 5.00
138 INT84260 Positive_regulation of Mapk8 124 0.69 72.84 35.98 5.00
139 INT53577 Negative_regulation of Localization of TNF 110 0.59 59.28 35.23 5.00
140 INT6105 Positive_regulation of IL2 133 0.69 82.76 34.67 5.00
141 INT81289 Positive_regulation of Gene_expression of Tlr4 192 0.69 104.5 33.89 5.00
142 INT52350 Gene_expression of CD14 184 0.75 71.37 33.13 5.00
143 INT8915 Gene_expression of Igf1 199 0.78 78.58 32.51 5.00
144 INT985 Negative_regulation of GH1 213 0.57 89.53 32.39 5.00
145 INT22939 Gene_expression of Csf2 164 0.78 85.1 32.22 5.00
146 INT88318 Gene_expression of CXCR4 208 0.77 189.67 31.72 5.00
147 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 5.00
148 INT10915 Gene_expression of ITGAM 164 0.78 92.42 29.78 5.00
149 INT5300 Regulation of Insr 54 0.60 11.33 29.26 5.00
150 INT19856 Gene_expression of CD8A 240 0.75 147.86 26.39 5.00
151 INT53482 Gene_expression of ITIH4 75 0.77 58.87 26.05 5.00
152 INT70048 Positive_regulation of Gene_expression of IL10 90 0.55 71.34 25.66 5.00
153 INT48235 Negative_regulation of NPEPPS 72 0.46 44.54 25.03 5.00
154 INT2614 Gene_expression of CGA 187 0.78 105.89 24.77 5.00
155 INT106272 Positive_regulation of Positive_regulation of Mapk14 39 0.70 32.08 24.71 5.00
156 INT17275 Gene_expression of HIVEP1 267 0.75 232.07 24.06 5.00
157 INT48536 Positive_regulation of Grm8 46 0.61 14.31 23.56 5.00
158 INT8775 Binding of IGHE 167 0.48 102.61 23.54 5.00
159 INT1704 Positive_regulation of PCa 68 0.59 34.92 23.36 5.00
160 INT134651 Binding of TLR4 89 0.48 66.96 23.19 5.00
161 INT5055 Positive_regulation of IFNG 89 0.69 64.03 23.05 5.00
162 INT956 Negative_regulation of PRL 94 0.59 42.72 23.01 5.00
163 INT74423 Localization of IL10 91 0.80 61.6 22.95 5.00
164 INT91891 Gene_expression of Kit 268 0.78 158.89 22.67 5.00
165 INT5328 Positive_regulation of CD4 191 0.69 133.43 21.31 5.00
166 INT85952 Positive_regulation of AR 168 0.67 64.36 20.66 5.00
167 INT48144 Gene_expression of Fgf2 117 0.78 43 20.48 5.00
168 INT18311 Positive_regulation of CD8A 145 0.69 113.48 19.44 5.00
169 INT192409 Positive_regulation of Gene_expression of IFN1@ 102 0.67 64.66 18.8 5.00
170 INT1578 Negative_regulation of Localization of PRL 52 0.59 20.62 17.18 5.00
171 INT16624 Localization of Grin1 38 0.79 8.46 17.15 5.00
172 INT93361 Gene_expression of Trp53 208 0.78 175.35 16.65 5.00
173 INT7970 Gene_expression of PLOD1 120 0.71 44.42 15.54 5.00
174 INT2064 Positive_regulation of BTG3 29 0.49 25.58 15.37 5.00
175 INT106745 Localization of CRP 65 0.81 66.44 15.21 5.00
176 INT12087 Regulation of Localization of TNF 44 0.62 28.71 15.17 5.00
177 INT89293 Positive_regulation of Gene_expression of CCR5 29 0.70 22.14 15 5.00
178 INT10709 Negative_regulation of CD4 106 0.59 95.6 14.89 5.00
179 INT61548 Positive_regulation of Fgf2 72 0.70 32.18 14.49 5.00
180 INT20420 Gene_expression of MYC 99 0.75 49.32 14.36 5.00
181 INT2005 Positive_regulation of Gene_expression of PRL 55 0.70 21.4 13.44 5.00
182 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32 5.00
183 INT104954 Negative_regulation of Positive_regulation of Mapk14 29 0.58 17.71 13.31 5.00
184 INT6478 Negative_regulation of Binding of TNF 36 0.58 30.42 13.31 5.00
185 INT4145 Gene_expression of FSHR 124 0.77 44.98 13.04 5.00
186 INT17539 Positive_regulation of Igf1 68 0.69 28.47 13.02 5.00
187 INT69158 Localization of IL4 48 0.71 31.3 11.98 5.00
188 INT102272 Regulation of TH1L 41 0.44 30.89 11.63 5.00
189 INT23177 Negative_regulation of Gene_expression of HLA-DRA 50 0.44 16.99 10.55 5.00
190 INT952 Negative_regulation of GHRH 57 0.56 25.3 10.34 5.00
191 INT103554 Positive_regulation of MTX1 19 0.45 11.23 10 5.00
192 INT81929 Negative_regulation of Gene_expression of IL10 41 0.57 27.99 9.87 5.00
193 INT69306 Negative_regulation of TH1L 28 0.57 24.81 9.74 5.00
194 INT3988 Positive_regulation of Gene_expression of IGHE 98 0.68 91.46 9.61 5.00
195 INT144689 Regulation of RCT 49 0.53 25.91 9.6 5.00
196 INT70134 Negative_regulation of TXK 124 0.23 81.96 9.59 5.00
197 INT1218 Negative_regulation of Maob 24 0.59 9.76 9.39 5.00
198 INT111998 Positive_regulation of Positive_regulation of Mapk8 23 0.69 9.33 8.97 5.00
199 INT86705 Gene_expression of BTG3 41 0.65 37.29 8.29 5.00
200 INT60034 Positive_regulation of VWF 40 0.68 30.42 8.15 5.00
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