D:Mucopolysaccharidoses

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Disease Term
Synonyms MUCOPOLYSACCHARIDOSIS
Documents 97
Hot Single Events 51
Hot Interactions 4

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Mucopolysaccharidoses. They are ordered first by their relevance to Mucopolysaccharidoses and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT310674 Positive_regulation of Binding of ARSB and ELF3 1 0.07 2.46 0.05 100.00
2 INT310675 Binding of ARSB and ELF3 1 0.06 2.4 0.05 100.00
3 INT277890 Binding of Ids and Tas2r111-ps2 1 0.08 0.5 0.09 98.84
4 INT277889 Regulation of Binding of Ids and Tas2r111-ps2 1 0.09 0.5 0.09 98.84
5 INT277892 IDS Regulation of Ids 1 0.18 0.41 0 50.00
6 INT277891 Binding of TPBG and M6pr-ps 1 0.02 0.06 0 50.00
7 INT331227 Binding of Becn1 and Pink1 1 0.03 1.13 0.05 5.00
8 INT331234 Binding of Becn1 and Pik3c3 Positive_regulation of Pik3c3 1 0.00 0.47 0 5.00
9 INT331226 Binding of Becn1 and Pik3c3 1 0.02 0.47 0 5.00
10 INT331238 Binding of ULK1 and Pik3r1 1 0.09 0.48 0 5.00
11 INT331237 Negative_regulation of IMPA1 Negative_regulation of Itpr3 1 0.00 0.52 0 5.00
12 INT331232 Binding of Atg12 and Atg16l1 1 0.03 0.08 0 5.00
13 INT282995 Binding of Bcl2 and Becn1 21 0.03 9.8 0 5.00
14 INT331222 Tsc1 Negative_regulation of Mtor 1 0.00 0.68 0 5.00
15 INT331235 RASA1 Positive_regulation of Mtor 1 0.00 0.32 0 5.00
16 INT273136 Binding of CHED1 and VSX1 1 0.15 0.12 0 5.00
17 INT331225 Binding of Atg5 and Atg16l1 1 0.05 0.08 0 5.00
18 INT331231 Binding of Bcl2 and Mapk8 1 0.01 0.77 0 5.00
19 INT331230 Binding of Mapk8 and Becn1 1 0.02 0.77 0 5.00
20 INT331228 Atg5 Positive_regulation of Atg12 1 0.06 0.08 0 5.00
21 INT331224 Binding of Akt1 and Tsc2 1 0.03 0.33 0 5.00
22 INT331223 Negative_regulation of Tsc1 Positive_regulation of Positive_regulation of Mtor 1 0.01 0.33 0 5.00
23 INT331229 Rasa1 Positive_regulation of Mtor 1 0.00 0.32 0 5.00
24 INT331233 Binding of Mtor and Rasa1 1 0.00 0.32 0 5.00
25 INT331236 Binding of RASA1 and Mtor 1 0.00 0.32 0 5.00
26 INT331221 Binding of Akt1 and Tsc1 1 0.03 0.33 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Mucopolysaccharidoses. They are ordered first by their pain relevance and then by number of times they were reported in Mucopolysaccharidoses. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT310680 Gene_expression of ARSB 1 0.64 6.28 0.12 100.00
2 INT310681 Negative_regulation of ARSB 1 0.56 6.95 0.29 100.00
3 INT310677 Localization of ARSB 1 0.71 5.72 0.14 100.00
4 INT105991 Negative_regulation of IDS 12 0.38 6.31 1.04 100.00
5 INT310679 Positive_regulation of ARSB 1 0.39 2.36 0.04 100.00
6 INT277880 Gene_expression of Tas2r111-ps2 1 0.13 1.22 0 100.00
7 INT291341 Phosphorylation of Ifnar1 2 0.03 0.99 0.22 100.00
8 INT19086 Negative_regulation of COL1A1 32 0.38 16.77 5.98 100.00
9 INT94173 Positive_regulation of CTSA 3 0.53 3.22 0.4 99.84
10 INT84245 Negative_regulation of MPEG1 2 0.20 1.46 0.1 99.82
11 INT38989 Gene_expression of IDUA 22 0.78 16.99 1.26 99.72
12 INT286477 Negative_regulation of Idua 1 0.03 1.28 0.09 99.70
13 INT38990 Negative_regulation of IDUA 12 0.59 5.04 1.33 99.62
14 INT3798 Negative_regulation of GNS 5 0.26 3.18 2.21 99.46
15 INT164757 Negative_regulation of Idua 1 0.14 1.48 0.32 99.42
16 INT32515 Negative_regulation of B4GALNT1 82 0.43 28.1 17.46 99.36
17 INT200462 Binding of IDS 13 0.31 4.95 1 99.32
18 INT277878 Binding of Ids 4 0.34 0.8 0.24 99.32
19 INT24974 Negative_regulation of Naglu 5 0.42 2.68 0.9 99.20
20 INT36354 Localization of CTs 26 0.64 20.84 9.31 99.06
21 INT94175 Negative_regulation of GALNT3 2 0.06 2.87 0.82 98.96
22 INT310682 Regulation of ARSB 1 0.43 0.98 0.04 98.90
23 INT153233 Negative_regulation of Ids 5 0.40 2.1 0.12 98.62
24 INT273143 Negative_regulation of Tat 1 0.01 2.3 0 98.44
25 INT44873 Negative_regulation of LCAT 16 0.59 6.92 3.13 98.44
26 INT217723 Regulation of IDS 15 0.25 2.12 0.49 97.92
27 INT94174 Negative_regulation of B3GALNT1 1 0.20 1.1 0.11 97.76
28 INT94176 Negative_regulation of NEU1 1 0.11 1.09 0.11 97.76
29 INT123031 Positive_regulation of Sgsh 2 0.42 1.01 0.09 97.72
30 INT116728 Negative_regulation of ARSH 9 0.13 9.67 0.27 97.62
31 INT222076 Gene_expression of Sgsh 1 0.04 1.22 0.08 97.36
32 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 96.60
33 INT105993 Gene_expression of IDS 26 0.78 10.83 2.41 95.28
34 INT67133 Gene_expression of Gusb 14 0.75 18.57 1.37 93.72
35 INT67134 Positive_regulation of Gene_expression of Gusb 3 0.34 1.37 0.05 93.72
36 INT291340 Phosphorylation of Mpeg1 1 0.51 0.36 0.08 92.96
37 INT121335 Localization of SCD 10 0.68 6.81 1.51 91.72
38 INT273154 Positive_regulation of Localization of SCD 1 0.03 0.94 0 91.72
39 INT94177 Positive_regulation of Positive_regulation of CTSA 1 0.38 0.76 0.06 90.68
40 INT17237 Regulation of Esr1 74 0.43 49.09 17.25 90.56
41 INT84247 Regulation of Gene_expression of IDUA 2 0.45 0.54 0.15 89.76
42 INT84244 Positive_regulation of Gene_expression of IDUA 5 0.70 3.75 0.19 88.24
43 INT273148 Localization of LCAT 1 0.38 0.91 0 86.52
44 INT273152 Positive_regulation of Localization of LCAT 1 0.26 0.91 0 86.52
45 INT67137 Positive_regulation of Mpeg1 4 0.26 9.67 2.73 83.00
46 INT277884 Binding of Tas2r111-ps2 1 0.09 0.95 0.19 82.72
47 INT56809 Binding of Tlr4 184 0.48 106.02 31.18 80.88
48 INT142754 Binding of Myd88 20 0.36 9.61 3.8 80.88
49 INT157301 Negative_regulation of Map1lc3a 5 0.28 3.2 0.41 80.56
50 INT254887 Negative_regulation of Lamp1 2 0.20 3.17 0 80.56
51 INT254876 Negative_regulation of Localization of Lamp1 2 0.20 2.07 0 80.56
52 INT254878 Localization of Map1lc3a 5 0.57 3.32 0.2 79.92
53 INT254882 Localization of Lamp1 3 0.43 2.05 0 79.92
54 INT5793 Binding of CTS 110 0.48 63.91 40.62 79.72
55 INT105992 Positive_regulation of Gene_expression of IDS 4 0.69 0.84 0.35 78.56
56 INT84250 Positive_regulation of IDUA 8 0.56 15.89 0.62 75.00
57 INT7533 Gene_expression of Tlr4 720 0.78 343.22 121.57 75.00
58 INT197491 Gene_expression of Myd88 32 0.74 14.59 5.29 75.00
59 INT69134 Positive_regulation of MPEG1 9 0.26 5.95 0.97 75.00
60 INT84248 Gene_expression of MPEG1 5 0.48 3.38 0.66 75.00
61 INT84246 Positive_regulation of Gene_expression of MPEG1 1 0.03 0.37 0.08 75.00
62 INT81289 Positive_regulation of Gene_expression of Tlr4 192 0.69 104.5 33.89 75.00
63 INT233975 Positive_regulation of Gene_expression of Myd88 7 0.66 4.17 1.65 75.00
64 INT103266 Positive_regulation of Positive_regulation of MPEG1 1 0.03 0.2 0.07 75.00
65 INT103267 Positive_regulation of Positive_regulation of IDUA 1 0.44 0.2 0.07 75.00
66 INT103760 Regulation of Gene_expression of Tlr4 35 0.59 16.26 5.95 75.00
67 INT197492 Regulation of Gene_expression of Myd88 2 0.39 1.95 0.27 75.00
68 INT84249 Regulation of Positive_regulation of MPEG1 1 0.02 0.28 0.06 75.00
69 INT1755 Gene_expression of GBE1 28 0.26 8.32 5.18 72.40
70 INT67136 Negative_regulation of Binding of Gc 1 0.05 0.9 0.06 71.12
71 INT67135 Binding of Gc 5 0.10 3.2 0.94 70.36
72 INT67138 Gene_expression of Gc 19 0.31 17.11 4.1 69.40
73 INT50212 Gene_expression of Ifx 33 0.75 32.17 7.26 68.80
74 INT73354 Gene_expression of Gap43 36 0.77 13.74 7.47 67.24
75 INT37296 Binding of Esr1 117 0.43 62.51 27.33 65.92
76 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 63.56
77 INT277886 Localization of Ids 3 0.73 1.09 0.48 59.28
78 INT151400 Binding of JAG1 14 0.37 7.96 0.39 55.00
79 INT141785 Negative_regulation of GALNS 3 0.59 1.92 0.09 54.32
80 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 50.00
81 INT1951 Positive_regulation of Tlr4 345 0.70 176.99 62.42 50.00
82 INT17886 Negative_regulation of Il1 95 0.57 70.91 31.25 50.00
83 INT15174 Gene_expression of Itgam 238 0.73 104.92 29.26 50.00
84 INT43906 Regulation of Tlr4 71 0.53 35.18 15.49 50.00
85 INT25076 Negative_regulation of Gene_expression of Il1 41 0.52 30.58 13.85 50.00
86 INT15172 Positive_regulation of Itgam 45 0.67 23.54 10.3 50.00
87 INT15173 Positive_regulation of Gene_expression of Itgam 59 0.49 21.89 5.43 50.00
88 INT61252 Negative_regulation of Gene_expression of Itgam 38 0.54 16.48 5.01 50.00
89 INT97254 Positive_regulation of Gap43 22 0.46 7.36 4.48 50.00
90 INT142752 Positive_regulation of Myd88 26 0.66 12.07 4.4 50.00
91 INT61316 Gene_expression of Coq10a 59 0.73 32.81 3.95 50.00
92 INT171117 Binding of Itgam 35 0.36 14.87 2.76 50.00
93 INT59321 Transcription of Il1 13 0.50 9.73 2.68 50.00
94 INT89981 Regulation of Gene_expression of Gap43 2 0.55 3.1 2.13 50.00
95 INT68829 Binding of ELF3 14 0.47 7.96 2 50.00
96 INT223091 Gene_expression of ELF3 45 0.62 17.9 1.56 50.00
97 INT274750 Gene_expression of Mpeg1 4 0.55 6.1 1.3 50.00
98 INT233970 Regulation of Myd88 7 0.45 5.2 1.28 50.00
99 INT233974 Negative_regulation of Negative_regulation of Il1 2 0.30 1.47 1.07 50.00
100 INT139160 Negative_regulation of Gap43 5 0.43 1.27 0.77 50.00
101 INT274748 Positive_regulation of Gene_expression of Mpeg1 3 0.41 0.59 0.61 50.00
102 INT233973 Negative_regulation of Gene_expression of Myd88 4 0.38 1.32 0.61 50.00
103 INT137221 Gene_expression of Sh2d1b2 6 0.47 1.99 0.6 50.00
104 INT137222 Positive_regulation of Sh2d1b2 5 0.30 1.26 0.6 50.00
105 INT42410 Positive_regulation of Cyb5d2 13 0.31 6.75 0.54 50.00
106 INT277882 Gene_expression of Ids 5 0.71 1.6 0.26 50.00
107 INT152888 Transcription of Itgam 4 0.44 1.29 0.25 50.00
108 INT47550 Gene_expression of Naglu 4 0.44 2.02 0.23 50.00
109 INT291342 Negative_regulation of Mpeg1 3 0.40 5.76 0.2 50.00
110 INT244330 Localization of ELF3 8 0.56 2.71 0.18 50.00
111 INT233971 Transcription of Myd88 2 0.60 1.01 0.17 50.00
112 INT87332 Gene_expression of Cyb5d2 8 0.65 2.85 0.15 50.00
113 INT277879 Positive_regulation of Gene_expression of Ids 3 0.44 0.14 0.11 50.00
114 INT229456 Negative_regulation of Gene_expression of Gap43 3 0.11 0.41 0.09 50.00
115 INT279349 Localization of IDUA 7 0.76 4.97 0.07 50.00
116 INT245115 Positive_regulation of Gene_expression of ELF3 8 0.40 2.23 0.06 50.00
117 INT198787 Localization of Cyb5d2 3 0.73 0.56 0.03 50.00
118 INT233972 Regulation of Gene_expression of Cyb5d2 1 0.16 0.17 0.03 50.00
119 INT277883 Regulation of Tas2r111-ps2 1 0.05 0.15 0 50.00
120 INT277881 Negative_regulation of Tas2r111-ps2 1 0.07 0.15 0 50.00
121 INT277888 Binding of TPBG 1 0.35 0.06 0 50.00
122 INT279351 Regulation of IDUA 2 0.36 1.71 0 50.00
123 INT279350 Regulation of Localization of IDUA 1 0.23 0 0 50.00
124 INT277877 Binding of M6pr-ps 1 0.02 0.06 0 50.00
125 INT222089 Positive_regulation of Localization of Esr1 19 0.49 8.73 1.58 44.52
126 INT17561 Localization of Car2 303 0.79 60.95 44.52 43.88
127 INT2038 Localization of Esr1 104 0.79 40.12 13.27 43.52
128 INT157302 Positive_regulation of Map1lc3a 27 0.66 11.31 0.79 35.52
129 INT157306 Positive_regulation of Positive_regulation of Map1lc3a 3 0.35 1.21 0.44 35.52
130 INT4067 Negative_regulation of Esr1 97 0.50 43.45 17.52 35.20
131 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34 32.24
132 INT303326 Gene_expression of CHMP2B 25 0.75 10.08 0.76 12.20
133 INT303303 Positive_regulation of Gene_expression of CHMP2B 2 0.49 0.97 0 12.20
134 INT3537 Positive_regulation of Car2 413 0.56 103.51 94.35 5.00
135 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34 5.00
136 INT106525 Phosphorylation of Akt1 436 0.82 183.81 47.82 5.00
137 INT30170 Gene_expression of Car2 330 0.66 77.26 46.76 5.00
138 INT96913 Positive_regulation of Mapk8 179 0.69 130.44 32.2 5.00
139 INT145426 Positive_regulation of Ros1 185 0.56 106.76 27.21 5.00
140 INT23564 Negative_regulation of Car2 103 0.50 27.28 21.86 5.00
141 INT112029 Positive_regulation of Pik3r1 90 0.67 38.76 20.95 5.00
142 INT11508 Positive_regulation of TGFBI 24 0.70 19.81 15.78 5.00
143 INT109511 Gene_expression of Bax 133 0.78 113.22 14.36 5.00
144 INT109304 Positive_regulation of Phosphorylation of Akt1 113 0.69 40.92 13.49 5.00
145 INT96915 Phosphorylation of Mapk8 73 0.81 40.69 11.44 5.00
146 INT25170 Positive_regulation of Localization of Car2 78 0.67 15.25 11.24 5.00
147 INT1129 Binding of Car2 69 0.35 14.01 9.2 5.00
148 INT53189 Gene_expression of VSX1 32 0.69 10.59 7.21 5.00
149 INT69289 Negative_regulation of Cftr 44 0.57 13.28 6.97 5.00
150 INT93359 Positive_regulation of Trp53 90 0.70 69.77 6.24 5.00
151 INT55655 Gene_expression of DCN 17 0.75 7.98 5.98 5.00
152 INT24080 Negative_regulation of Mtor 64 0.37 41.56 5.19 5.00
153 INT116744 Binding of Pik3r1 22 0.36 12.77 5.01 5.00
154 INT76467 Regulation of Gene_expression of Car2 41 0.37 12.88 4.21 5.00
155 INT75136 Binding of Akt1 27 0.27 8.81 4.15 5.00
156 INT4988 Gene_expression of KRT1 64 0.77 43.4 4.12 5.00
157 INT52678 Positive_regulation of VSX1 15 0.42 3.94 3.64 5.00
158 INT151171 Positive_regulation of Pten 20 0.55 13.3 3.54 5.00
159 INT2117 Regulation of VSX1 15 0.30 3.38 3.38 5.00
160 INT151586 Positive_regulation of Prkag1 51 0.54 18.7 3.34 5.00
161 INT14281 Gene_expression of Hspa5 44 0.63 34.19 3.31 5.00
162 INT4596 Positive_regulation of SCD 18 0.42 22.59 3.26 5.00
163 INT87314 Gene_expression of Htt 112 0.78 55.82 3.03 5.00
164 INT36039 Gene_expression of Itpr3 19 0.72 3.75 2.93 5.00
165 INT195978 Gene_expression of Hsp90b1 26 0.65 11.28 2.88 5.00
166 INT64464 Gene_expression of Reg3b 4 0.77 10.95 2.77 5.00
167 INT222088 Gene_expression of Dnajb1 11 0.65 3.37 2.18 5.00
168 INT55529 Negative_regulation of Gba 13 0.59 7.91 2.1 5.00
169 INT195968 Positive_regulation of Gene_expression of Hsp90b1 10 0.49 5.21 2.02 5.00
170 INT2116 Negative_regulation of VSX1 29 0.36 10.67 1.89 5.00
171 INT85084 Gene_expression of KRT19 66 0.73 42.56 1.82 5.00
172 INT98687 Gene_expression of Calr 38 0.61 7.03 1.59 5.00
173 INT118559 Positive_regulation of Hspa5 20 0.61 15.66 1.45 5.00
174 INT126370 Localization of VSX1 6 0.56 1.7 1.28 5.00
175 INT195977 Transcription of Hsp90b1 5 0.56 1.74 1.27 5.00
176 INT60281 Negative_regulation of Negative_regulation of Car2 4 0.36 1.88 1.26 5.00
177 INT174156 Localization of Trp53 16 0.72 13.52 1.18 5.00
178 INT172855 Binding of Bcl2 37 0.32 23.41 1.09 5.00
179 INT151774 Positive_regulation of Mtor 38 0.45 20.15 1.01 5.00
180 INT128755 Protein_catabolism of Esr1 10 0.57 4.61 0.9 5.00
181 INT69616 Binding of Lamp2 2 0.21 0.74 0.85 5.00
182 INT59175 Localization of TNMD 4 0.70 4.14 0.71 5.00
183 INT236094 Localization of Gdnf 4 0.70 2.51 0.68 5.00
184 INT47553 Gene_expression of ARSH 11 0.42 4.93 0.65 5.00
185 INT282380 Binding of Atg16l1 4 0.38 2.06 0.58 5.00
186 INT86246 Binding of Bcl2l1 8 0.37 6.67 0.57 5.00
187 INT4597 Regulation of SCD 5 0.39 2.25 0.5 5.00
188 INT189634 Regulation of DCN 3 0.25 1.69 0.49 5.00
189 INT222077 Regulation of Hsp90b1 9 0.37 4.78 0.45 5.00
190 INT73976 Gene_expression of Hsp90aa1 18 0.75 7.92 0.45 5.00
191 INT243418 Binding of Htt 14 0.30 5.94 0.44 5.00
192 INT166435 Negative_regulation of Atp2a2 8 0.43 0.4 0.44 5.00
193 INT154748 Positive_regulation of Gene_expression of Hspa5 11 0.44 7.66 0.44 5.00
194 INT250447 Positive_regulation of Binding of Car2 3 0.11 0.36 0.39 5.00
195 INT165342 Gene_expression of TGFBI 13 0.59 5.81 0.39 5.00
196 INT236107 Binding of Pdpk1 2 0.26 1.38 0.39 5.00
197 INT135045 Gene_expression of Atxn3 34 0.78 11.59 0.36 5.00
198 INT151167 Phosphorylation of Pten 3 0.72 1.69 0.35 5.00
199 INT151166 Positive_regulation of Phosphorylation of Pten 2 0.40 1.54 0.35 5.00
200 INT179816 Positive_regulation of Pdpk1 4 0.31 0.36 0.35 5.00
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