D:Mucopolysaccharidosis I

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pChart

Disease Term
Synonyms Disease Hurler, Disease Hurler S, GARGOYLISM HURLER SYNDROME, Hurler Disease, HURLER S DISEASE, Hurler S Syndrome, Hurler Scheie Syndrome, Hurler Syndrome, HURLER SYNDROME GARGOYLISM, HURLERS DISEASE, Hurlers Syndrome
Documents 24
Hot Single Events 12
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Mucopolysaccharidosis I. They are ordered first by their relevance to Mucopolysaccharidosis I and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT277891 Binding of TPBG and M6pr-ps 1 0.02 0.06 0 34.84
2 INT277890 Binding of Ids and Tas2r111-ps2 1 0.08 0.5 0.09 5.00
3 INT277889 Regulation of Binding of Ids and Tas2r111-ps2 1 0.09 0.5 0.09 5.00
4 INT310674 Positive_regulation of Binding of ARSB and ELF3 1 0.07 2.46 0.05 5.00
5 INT310675 Binding of ARSB and ELF3 1 0.06 2.4 0.05 5.00
6 INT277892 IDS Regulation of Ids 1 0.18 0.41 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Mucopolysaccharidosis I. They are ordered first by their pain relevance and then by number of times they were reported in Mucopolysaccharidosis I. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT84248 Gene_expression of MPEG1 5 0.48 3.38 0.66 100.00
2 INT180589 Phosphorylation of COL1A1 3 0.34 0.37 0.03 99.66
3 INT321259 Binding of MPEG1 1 0.20 2.25 0.21 99.22
4 INT321258 Positive_regulation of Binding of MPEG1 1 0.26 1.59 0.16 99.22
5 INT164757 Negative_regulation of Idua 1 0.14 1.48 0.32 98.88
6 INT84245 Negative_regulation of MPEG1 2 0.20 1.46 0.1 98.40
7 INT234263 Negative_regulation of ELF3 6 0.39 3.9 0.04 96.74
8 INT223091 Gene_expression of ELF3 45 0.62 17.9 1.56 94.20
9 INT38990 Negative_regulation of IDUA 12 0.59 5.04 1.33 90.72
10 INT36354 Localization of CTs 26 0.64 20.84 9.31 90.56
11 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 88.60
12 INT69134 Positive_regulation of MPEG1 9 0.26 5.95 0.97 83.72
13 INT279349 Localization of IDUA 7 0.76 4.97 0.07 74.84
14 INT277880 Gene_expression of Tas2r111-ps2 1 0.13 1.22 0 71.12
15 INT105991 Negative_regulation of IDS 12 0.38 6.31 1.04 69.52
16 INT274750 Gene_expression of Mpeg1 4 0.55 6.1 1.3 62.28
17 INT274748 Positive_regulation of Gene_expression of Mpeg1 3 0.41 0.59 0.61 62.28
18 INT105993 Gene_expression of IDS 26 0.78 10.83 2.41 56.92
19 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 50.00
20 INT277882 Gene_expression of Ids 5 0.71 1.6 0.26 45.44
21 INT277877 Binding of M6pr-ps 1 0.02 0.06 0 34.84
22 INT277888 Binding of TPBG 1 0.35 0.06 0 34.00
23 INT38989 Gene_expression of IDUA 22 0.78 16.99 1.26 33.68
24 INT245115 Positive_regulation of Gene_expression of ELF3 8 0.40 2.23 0.06 32.32
25 INT68829 Binding of ELF3 14 0.47 7.96 2 25.44
26 INT277879 Positive_regulation of Gene_expression of Ids 3 0.44 0.14 0.11 21.20
27 INT244330 Localization of ELF3 8 0.56 2.71 0.18 13.40
28 INT279351 Regulation of IDUA 2 0.36 1.71 0 13.00
29 INT279350 Regulation of Localization of IDUA 1 0.23 0 0 13.00
30 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 5.00
31 INT16364 Gene_expression of HLA-DRA 234 0.78 118.81 45.01 5.00
32 INT65245 Gene_expression of Nos3 121 0.78 98.14 41.56 5.00
33 INT7675 Gene_expression of ENG 146 0.77 45.35 34.6 5.00
34 INT90792 Localization of Il10 144 0.80 87.88 30.03 5.00
35 INT43486 Positive_regulation of Ifng 52 0.69 32.71 24.77 5.00
36 INT12922 Gene_expression of Atp9a 115 0.75 50.95 17.01 5.00
37 INT56447 Positive_regulation of Icam1 64 0.64 64.14 16.16 5.00
38 INT170308 Gene_expression of Ido1 159 0.75 69.51 15.98 5.00
39 INT108480 Gene_expression of CCL21 53 0.77 37.87 14.42 5.00
40 INT24876 Gene_expression of CD34 172 0.78 91.02 12.39 5.00
41 INT69029 Gene_expression of PTPRC 127 0.75 74.26 11.57 5.00
42 INT3845 Gene_expression of GSR 79 0.76 44.69 11.19 5.00
43 INT34777 Localization of IGF1 82 0.80 42.68 8.62 5.00
44 INT126478 Gene_expression of Cxcl12 78 0.77 58.69 8.01 5.00
45 INT86805 Localization of HGF 49 0.71 28.48 6.35 5.00
46 INT57256 Gene_expression of HLA-DQA2 52 0.55 23.87 6.27 5.00
47 INT61417 Gene_expression of ITGAL 36 0.75 29.62 6.15 5.00
48 INT126481 Gene_expression of Cxcr4 69 0.77 34.99 6 5.00
49 INT101594 Positive_regulation of Cd40 36 0.69 16.14 4.56 5.00
50 INT154527 Gene_expression of POU5F1 180 0.78 34.01 4.34 5.00
51 INT48411 Gene_expression of Cd44 35 0.77 27.05 4.29 5.00
52 INT38066 Binding of MSC 14 0.41 5.28 4.12 5.00
53 INT170738 Binding of Icam1 23 0.37 25.49 4.09 5.00
54 INT126477 Gene_expression of Sdf2l1 43 0.66 22.02 3.97 5.00
55 INT62784 Gene_expression of NT5E 46 0.65 15.95 3.72 5.00
56 INT19491 Gene_expression of CD19 44 0.75 28.8 3.47 5.00
57 INT96150 Gene_expression of H2-D1 44 0.27 16.23 3.4 5.00
58 INT28359 Gene_expression of Pdcd1 39 0.57 34.09 3.4 5.00
59 INT137609 Localization of Vegfa 22 0.78 14.67 3.01 5.00
60 INT57699 Positive_regulation of CD1A 11 0.50 8.49 2.93 5.00
61 INT37715 Positive_regulation of MSC 34 0.48 10.52 2.92 5.00
62 INT85078 Positive_regulation of PCNA 36 0.49 17.06 2.81 5.00
63 INT22071 Positive_regulation of Gene_expression of ENG 13 0.50 5.44 2.62 5.00
64 INT182224 Binding of CCL21 6 0.34 5.91 2.54 5.00
65 INT170469 Gene_expression of THY1 66 0.65 11.9 2.15 5.00
66 INT226637 Negative_regulation of Cxcr4 41 0.48 24.42 1.91 5.00
67 INT228401 Positive_regulation of Cd86 24 0.53 6.46 1.8 5.00
68 INT189302 Positive_regulation of Gene_expression of HLA-DQA2 6 0.06 4.44 1.48 5.00
69 INT187458 Positive_regulation of Gene_expression of H2-D1 11 0.14 4.85 1.44 5.00
70 INT210220 Positive_regulation of Sdf2l1 13 0.51 7.88 1.4 5.00
71 INT165564 Positive_regulation of Gene_expression of Sdf2l1 6 0.59 9.54 1.17 5.00
72 INT131161 Binding of CD58 5 0.17 3.54 1.03 5.00
73 INT263053 Gene_expression of ERC1 4 0.65 0.6 1 5.00
74 INT200462 Binding of IDS 13 0.31 4.95 1 5.00
75 INT233330 Localization of LEFTY2 4 0.15 4.46 0.99 5.00
76 INT144429 Positive_regulation of Cdkn2a 7 0.58 4.05 0.78 5.00
77 INT226688 Negative_regulation of Sdf2l1 14 0.50 6.52 0.72 5.00
78 INT47553 Gene_expression of ARSH 11 0.42 4.93 0.65 5.00
79 INT84250 Positive_regulation of IDUA 8 0.56 15.89 0.62 5.00
80 INT137221 Gene_expression of Sh2d1b2 6 0.47 1.99 0.6 5.00
81 INT137222 Positive_regulation of Sh2d1b2 5 0.30 1.26 0.6 5.00
82 INT263054 Positive_regulation of ERC1 2 0.49 0.78 0.49 5.00
83 INT217723 Regulation of IDS 15 0.25 2.12 0.49 5.00
84 INT277886 Localization of Ids 3 0.73 1.09 0.48 5.00
85 INT252308 Positive_regulation of Cd80 9 0.51 1.24 0.45 5.00
86 INT119251 Positive_regulation of Gene_expression of CD34 12 0.49 5.2 0.44 5.00
87 INT247955 Binding of Pdcd1 5 0.12 4.85 0.4 5.00
88 INT339606 Regulation of Gene_expression of Pdcd1 2 0.05 1.13 0.32 5.00
89 INT310681 Negative_regulation of ARSB 1 0.56 6.95 0.29 5.00
90 INT116728 Negative_regulation of ARSH 9 0.13 9.67 0.27 5.00
91 INT277878 Binding of Ids 4 0.34 0.8 0.24 5.00
92 INT291341 Phosphorylation of Ifnar1 2 0.03 0.99 0.22 5.00
93 INT235665 Positive_regulation of Pcdhb16 3 0.08 3.18 0.22 5.00
94 INT291342 Negative_regulation of Mpeg1 3 0.40 5.76 0.2 5.00
95 INT241693 Positive_regulation of Alcam 3 0.30 2.8 0.19 5.00
96 INT277884 Binding of Tas2r111-ps2 1 0.09 0.95 0.19 5.00
97 INT310677 Localization of ARSB 1 0.71 5.72 0.14 5.00
98 INT339611 Positive_regulation of CD58 1 0.12 0.9 0.13 5.00
99 INT310680 Gene_expression of ARSB 1 0.64 6.28 0.12 5.00
100 INT153233 Negative_regulation of Ids 5 0.40 2.1 0.12 5.00
101 INT286477 Negative_regulation of Idua 1 0.03 1.28 0.09 5.00
102 INT339608 Localization of Ido1 1 0.14 0.41 0.08 5.00
103 INT291340 Phosphorylation of Mpeg1 1 0.51 0.36 0.08 5.00
104 INT339605 Binding of Pcdhb16 1 0.02 0.45 0.07 5.00
105 INT310678 Protein_catabolism of ARSH 1 0.06 1.76 0.04 5.00
106 INT310683 Protein_catabolism of ARSB 1 0.73 1.85 0.04 5.00
107 INT310682 Regulation of ARSB 1 0.43 0.98 0.04 5.00
108 INT310679 Positive_regulation of ARSB 1 0.39 2.36 0.04 5.00
109 INT277883 Regulation of Tas2r111-ps2 1 0.05 0.15 0 5.00
110 INT277881 Negative_regulation of Tas2r111-ps2 1 0.07 0.15 0 5.00
111 INT326367 Gene_expression of Podxl 3 0.69 0.63 0 5.00
112 INT339607 Negative_regulation of Gene_expression of Podxl 1 0.12 0.2 0 5.00
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