D:Multiple Endocrine Neoplasia

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Disease Term
Synonyms ADENOMATOSES FAMILIAL ENDOCRINE, Adenomatoses Multiple Endocrine, ADENOMATOSIS FAMILIAL ENDOCRINE, Adenomatosis Multiple Endocrine, Adenopathies Multiple Endocrine, Adenopathy Multiple Endocrine, Endocrine Adenomatoses Familial, ENDOCRINE ADENOMATOSES MULTIPLE, Endocrine Adenomatosis Familial, Endocrine Adenomatosis Multiple, Endocrine Adenopathies Multiple
Documents 132
Hot Single Events 49
Hot Interactions 3

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Multiple Endocrine Neoplasia. They are ordered first by their relevance to Multiple Endocrine Neoplasia and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT229635 SPINK5 Positive_regulation of NF1 1 0.01 2.17 0.3 100.00
2 INT84622 Binding of RERE and KAL1 1 0.00 1.18 0.07 86.28
3 INT258522 Binding of DDR1 and RET 1 0.03 1.05 0.1 85.48
4 INT308432 Binding of PDE4A and Aip 1 0.05 3.1 0.05 46.00
5 INT308425 Binding of Pde2a and Aip 1 0.04 1.37 0 46.00
6 INT243465 Binding of GH1 and GOPC 1 0.02 0.99 0.09 44.48
7 INT74015 Binding of VHL and XRCC1 1 0.07 3.51 0.09 12.64
8 INT258521 EGFR Positive_regulation of MMP2 1 0.39 0.91 0.24 5.00
9 INT258565 EGFR Positive_regulation of Meta 1 0.39 0.89 0.23 5.00
10 INT197811 Binding of SMS and SST 1 0.00 0.98 0.21 5.00
11 INT229634 GOPC Positive_regulation of GAST 1 0.09 0.47 0.19 5.00
12 INT258527 Binding of BRAF and RET 1 0.21 1.49 0.11 5.00
13 INT218784 Binding of TCEB2 and VHL 1 0.04 3.81 0.1 5.00
14 INT243468 Binding of SSTR1 and SSTR5 1 0.05 0.99 0.1 5.00
15 INT243466 POU1F1 Regulation of GH1 1 0.11 1.26 0.08 5.00
16 INT243464 POU1F1 Regulation of PRL 1 0.28 1.26 0.08 5.00
17 INT218614 INS Positive_regulation of Binding of IGF1 1 0.39 0.79 0.05 5.00
18 INT218616 Binding of IGFBP3 and INS 1 0.07 0.68 0.05 5.00
19 INT200212 Binding of EPAS1 and VHL 3 0.06 4.1 0.05 5.00
20 INT202231 Binding of IGF1 and INS 2 0.28 1.38 0.03 5.00
21 INT199159 Binding of RET and Pheo 1 0.04 1.42 0.03 5.00
22 INT197808 Binding of MEN1 and NME1 1 0.00 1.81 0 5.00
23 INT291330 Binding of ENO1 and NOTCH1 1 0.03 1.33 0 5.00
24 INT197809 Binding of MEN1 and VIM 1 0.04 0.52 0 5.00
25 INT197810 Binding of MEN1 and MUC1 1 0.06 0.47 0 5.00
26 INT258524 IPMK Negative_regulation of KDR 2 0.00 1.98 0 5.00
27 INT291329 Binding of NOTCH1 and CERS1 1 0.06 1.42 0 5.00
28 INT197816 Binding of MEN1 and NFKB1 1 0.05 0.07 0 5.00
29 INT197813 Binding of AMBP and MEN1 1 0.00 0.51 0 5.00
30 INT243467 PCSK1 Positive_regulation of POMC 1 0.08 1.62 0 5.00
31 INT197812 Binding of AMBP and RDBP 1 0.00 0.51 0 5.00
32 INT291335 Positive_regulation of RAF1 Positive_regulation of Phosphorylation of GSK3A 1 0.07 0.88 0 5.00
33 INT258523 Positive_regulation of RAF1 Positive_regulation of Phosphorylation of GSK 1 0.19 0.64 0 5.00
34 INT258528 Binding of NOTCH1 and DLL1 2 0.07 1.6 0 5.00
35 INT197817 Binding of JUND and MEN1 1 0.18 0.14 0 5.00
36 INT218615 Negative_regulation of INS Negative_regulation of Gene_expression of IGF1 1 0.33 0.89 0 5.00
37 INT251983 XRCC1 Regulation of Binding of MET 1 0.05 0.4 0 5.00
38 INT197844 Binding of MEN1 and Nfkb1 1 0.06 0.26 0 5.00
39 INT258526 IPMK Negative_regulation of BRAF 1 0.01 1.11 0 5.00
40 INT197815 Binding of MEN1 and TGFB1 1 0.16 0.13 0 5.00
41 INT258529 Binding of JAG1 and NOTCH1 3 0.06 2.44 0 5.00
42 INT258525 IPMK Negative_regulation of DDR1 2 0.00 1.97 0 5.00
43 INT189021 NOX5 Positive_regulation of ROS1 1 0.26 0.2 0 5.00
44 INT291333 Binding of CSHL1 and NOTCH1 1 0.05 1.16 0 5.00
45 INT291331 Negative_regulation of GSK3A Positive_regulation of Positive_regulation of RAF1 1 0.07 0.94 0 5.00
46 INT218785 Binding of FN1 and VHL 1 0.06 1.12 0 5.00
47 INT308426 Binding of Pde4a and Aip 1 0.02 0.89 0 5.00
48 INT197814 Binding of MEN1 and RELA 1 0.42 0.07 0 5.00
49 INT258564 Binding of NOTCH1 and Crlf2 1 0.27 0.67 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Multiple Endocrine Neoplasia. They are ordered first by their pain relevance and then by number of times they were reported in Multiple Endocrine Neoplasia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT83461 Binding of RET 8 0.47 9.7 0.87 100.00
2 INT79784 Positive_regulation of RET 15 0.57 17.43 0.71 100.00
3 INT3364 Binding of SGCG 87 0.47 31.93 17.24 100.00
4 INT38625 Gene_expression of ELL 8 0.58 12.53 1 100.00
5 INT9292 Positive_regulation of SGCG 93 0.67 35.13 23.48 100.00
6 INT63333 Gene_expression of RET 24 0.76 30.09 2.41 99.52
7 INT425 Localization of PRL 455 0.81 189.64 144.8 99.04
8 INT1108 Gene_expression of PPY 58 0.75 36.57 10.76 98.84
9 INT327715 Binding of CNC 1 0.07 1.21 0.07 98.08
10 INT326 Gene_expression of Gnrhr 105 0.76 35.87 34.93 97.66
11 INT1893 Localization of Gh 1041 0.79 340.23 256.58 97.42
12 INT217539 Localization of INSM1 1 0.04 7.01 0.2 96.52
13 INT8159 Binding of ELL 7 0.36 12.62 0.84 96.40
14 INT30309 Gene_expression of Golga3 1 0.54 0.72 0.09 96.28
15 INT145155 Regulation of Positive_regulation of EGFR 6 0.38 4.54 0.33 95.88
16 INT258549 Regulation of Positive_regulation of Meta 3 0.44 2.31 0.4 95.88
17 INT89 Positive_regulation of Gast 187 0.70 80.49 42.07 95.32
18 INT108344 Regulation of Sdhb 1 0.29 1.34 0.11 95.28
19 INT19795 Positive_regulation of EGFR 161 0.70 103.69 11.55 95.16
20 INT4860 Positive_regulation of CALCA 148 0.00 73.35 97.61 94.80
21 INT957 Positive_regulation of GHRH 136 0.70 36.84 40.52 94.00
22 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 93.68
23 INT258548 Positive_regulation of Meta 10 0.67 5.05 1.42 93.16
24 INT914 Positive_regulation of GH1 292 0.69 100.7 84.91 92.92
25 INT28 Regulation of Gast 106 0.62 26.37 29.85 92.88
26 INT156 Negative_regulation of Prl 542 0.59 131.97 192.24 92.80
27 INT955 Gene_expression of GHRH 126 0.78 59.91 20.74 91.72
28 INT24282 Negative_regulation of PRDM16 1 0.41 0.63 1.3 91.68
29 INT90 Localization of Gast 400 0.81 137.67 113 90.40
30 INT2542 Localization of Calca 2008 0.81 518.3 1408.65 90.00
31 INT3180 Positive_regulation of PPY 39 0.63 25.57 10.15 89.56
32 INT22707 Positive_regulation of Eno2 36 0.69 27.31 5.07 89.56
33 INT217536 Regulation of INSM1 1 0.02 1.38 0.04 88.88
34 INT115423 Gene_expression of Men1 4 0.47 14.08 0.64 88.08
35 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82 88.08
36 INT14572 Binding of INS 205 0.48 175.43 13.38 87.12
37 INT31793 Transcription of Pgc 2 0.52 2.45 0.29 86.72
38 INT1579 Gene_expression of PRL 279 0.78 119.2 55.41 86.36
39 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 86.12
40 INT18462 Positive_regulation of Pgc 29 0.57 22.55 3.24 85.76
41 INT2543 Positive_regulation of Calca 787 0.70 331.13 592.08 85.52
42 INT62684 Negative_regulation of TP53 66 0.58 66.09 4.62 84.80
43 INT56925 Negative_regulation of TSC1 54 0.52 63.39 1.87 84.80
44 INT84623 Binding of KAL1 1 0.02 1.16 0.06 84.60
45 INT192337 Positive_regulation of DDR1 11 0.41 10.34 2.38 84.56
46 INT114091 Negative_regulation of Aip 6 0.48 4.16 1.3 84.40
47 INT2544 Localization of PTH 39 0.81 30.55 2.22 82.08
48 INT812 Localization of INS 1026 0.81 515.6 145.31 81.08
49 INT138872 Gene_expression of SPINK5 21 0.58 30.11 4.12 80.52
50 INT11551 Localization of VHL 12 0.65 22.76 0.68 79.28
51 INT13995 Gene_expression of gr 96 0.74 48.21 26.54 77.92
52 INT77249 Positive_regulation of Gene_expression of gr 24 0.67 16.09 8.17 77.92
53 INT66041 Positive_regulation of NTRK1 24 0.70 16.12 8.42 77.64
54 INT77252 Gene_expression of Nr3c1 17 0.67 9.71 5.38 77.60
55 INT77250 Positive_regulation of Gene_expression of Nr3c1 4 0.44 3.32 2.64 77.60
56 INT308431 Gene_expression of CNC 1 0.01 2.84 0.18 77.32
57 INT208125 Gene_expression of DDR1 10 0.06 8.15 1.03 76.72
58 INT217537 Gene_expression of INSM1 1 0.04 5.1 0.04 76.52
59 INT8347 Gene_expression of SST 181 0.78 104.59 65.45 76.40
60 INT14823 Gene_expression of MET 103 0.75 51.92 32.48 76.40
61 INT443 Localization of POMC 1020 0.81 284.52 443.17 75.08
62 INT61102 Gene_expression of MEN1 12 0.78 17.7 0.43 75.00
63 INT744 Positive_regulation of PTH 130 0.70 95.02 11.7 75.00
64 INT3824 Negative_regulation of PTH 40 0.59 28.58 3.39 75.00
65 INT2541 Binding of Calca 200 0.48 67.14 134.62 74.96
66 INT2540 Negative_regulation of Calca 538 0.59 172.11 384.38 71.68
67 INT14822 Positive_regulation of Binding of MET 3 0.49 1.35 1.94 70.20
68 INT12464 Binding of MET 38 0.47 10.3 13.15 69.80
69 INT191253 Negative_regulation of DDR1 13 0.25 10.05 1.05 69.28
70 INT15803 Regulation of IFNG 21 0.44 12.57 5.98 69.08
71 INT34054 Regulation of Gene_expression of IFNG 8 0.42 3.69 3.76 69.08
72 INT5056 Gene_expression of IFNG 216 0.78 137.52 74.57 68.80
73 INT60279 Gene_expression of VHL 70 0.78 75.21 2.21 67.76
74 INT66941 Localization of NTRK1 8 0.78 5.89 1.96 67.64
75 INT915 Positive_regulation of PRL 342 0.70 141.96 104.31 67.04
76 INT64849 Gene_expression of Ret 24 0.75 14.36 9.1 65.80
77 INT2243 Localization of GAST 67 0.81 34.54 16.19 65.68
78 INT64346 Positive_regulation of S100B 95 0.70 63.11 9.17 62.96
79 INT15652 Positive_regulation of ENO2 37 0.68 33.39 5.02 62.96
80 INT1498 Gene_expression of Gh 521 0.75 220.84 81.16 62.20
81 INT3230 Negative_regulation of Negative_regulation of Prl 9 0.43 1.85 4.41 61.76
82 INT235467 Negative_regulation of Gene_expression of VHL 9 0.43 8.67 0 58.16
83 INT218 Positive_regulation of Th 245 0.70 40.5 120.1 55.36
84 INT671 Positive_regulation of Cea 221 0.69 164.5 47.79 53.36
85 INT1624 Gene_expression of Cea 212 0.76 180.44 34.21 53.36
86 INT5617 Localization of Nppa 266 0.81 83.51 83.89 53.12
87 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 52.72
88 INT3300 Positive_regulation of Gene_expression of Calca 179 0.70 77.76 144.2 52.72
89 INT48312 Gene_expression of NTRK1 72 0.78 38.21 22.24 51.36
90 INT7383 Localization of VIP 53 0.81 17.7 22.65 49.68
91 INT626 Localization of CALCA 289 0.81 125.39 221.15 48.64
92 INT197 Gene_expression of Hrh2 24 0.63 12.35 8.37 47.96
93 INT2867 Gene_expression of CALCA 247 0.78 78.78 138.47 47.84
94 INT767 Localization of Gnrhr 565 0.80 106.68 214.57 46.56
95 INT1438 Localization of Pomc 360 0.81 101.26 116.47 46.56
96 INT397 Localization of SST 232 0.81 58.05 101.19 46.56
97 INT74017 Regulation of VHL 4 0.43 7.59 0.16 40.24
98 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 39.96
99 INT156165 Regulation of Gene_expression of NTRK1 2 0.37 1.91 0.27 39.60
100 INT148702 Positive_regulation of UPF1 29 0.31 12.9 1.91 36.52
101 INT148671 Gene_expression of Aip 26 0.63 24.32 3.91 35.44
102 INT185287 Transcription of VHL 2 0.60 3.77 0 35.28
103 INT251997 Negative_regulation of Transcription of VHL 1 0.37 1.32 0 35.28
104 INT173080 Positive_regulation of Gene_expression of VHL 3 0.50 9.58 0.1 34.24
105 INT16130 Binding of IGF1 67 0.48 27.43 2.95 32.24
106 INT152200 Positive_regulation of Pheo 3 0.11 1.59 0.52 32.04
107 INT21487 Negative_regulation of HCC 18 0.49 29.81 1.88 19.40
108 INT8490 Negative_regulation of CALCA 87 0.59 29.73 51.34 15.84
109 INT219879 Positive_regulation of SPINK5 4 0.30 7.64 1.16 15.28
110 INT200219 Positive_regulation of VHL 18 0.50 15.38 0.67 14.96
111 INT173086 Negative_regulation of VHL 14 0.59 12.54 0.29 11.64
112 INT121493 Gene_expression of XRCC1 55 0.65 73.43 2.76 8.88
113 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 8.48
114 INT120519 Localization of XRCC1 15 0.78 17.03 1.51 8.24
115 INT25438 Positive_regulation of Positive_regulation of Pomc 6 0.48 4 2.37 5.64
116 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 5.00
117 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
118 INT6665 Gene_expression of FOS 520 0.77 165.31 217.66 5.00
119 INT739 Negative_regulation of POMC 358 0.59 102.28 166.77 5.00
120 INT3448 Positive_regulation of Gh 521 0.69 180.03 161.18 5.00
121 INT2640 Gene_expression of Pomc 424 0.78 120.72 155.37 5.00
122 INT252 Localization of GH1 529 0.80 227.4 122.05 5.00
123 INT62124 Gene_expression of NOS1 444 0.78 218.08 114.85 5.00
124 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 5.00
125 INT17459 Positive_regulation of Gene_expression of FOS 182 0.67 53.45 96.38 5.00
126 INT203 Positive_regulation of Pomc 257 0.70 90.56 92.84 5.00
127 INT48767 Negative_regulation of NOS1 312 0.59 154.25 90.32 5.00
128 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 5.00
129 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 5.00
130 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 5.00
131 INT4241 Regulation of CALCA 87 0.62 28.19 55.29 5.00
132 INT251 Regulation of INS 398 0.62 232.47 55.04 5.00
133 INT249 Localization of GHRH 215 0.80 78.02 51.87 5.00
134 INT5118 Regulation of SST 97 0.62 34.35 51.74 5.00
135 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 5.00
136 INT375 Positive_regulation of REN 293 0.70 152.46 47.55 5.00
137 INT531 Gene_expression of GH1 376 0.75 193.45 46.24 5.00
138 INT1322 Positive_regulation of Localization of INS 293 0.70 120.86 45.98 5.00
139 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 5.00
140 INT66383 Phosphorylation of Prkaca 143 0.80 30.85 43.38 5.00
141 INT4004 Gene_expression of IGHG3 321 0.71 221.03 42.33 5.00
142 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 5.00
143 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 5.00
144 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 5.00
145 INT1931 Positive_regulation of Gene_expression of POMC 116 0.70 37.26 38.67 5.00
146 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 5.00
147 INT3253 Negative_regulation of Localization of INS 205 0.59 130.39 36.61 5.00
148 INT2274 Regulation of Localization of INS 101 0.62 41.55 34.79 5.00
149 INT67613 Positive_regulation of PPARG 94 0.70 69.15 34.38 5.00
150 INT74563 Positive_regulation of Gene_expression of ROS1 258 0.61 168.18 34.08 5.00
151 INT691 Binding of SST 67 0.48 24.66 32.67 5.00
152 INT985 Negative_regulation of GH1 213 0.57 89.53 32.39 5.00
153 INT48693 Regulation of VEGFA 268 0.62 191.88 31.52 5.00
154 INT6277 Positive_regulation of Gene_expression of Pomc 76 0.70 21.45 31.09 5.00
155 INT719 Negative_regulation of SGCG 96 0.57 47.91 30.22 5.00
156 INT660 Negative_regulation of REN 194 0.59 82.06 29.46 5.00
157 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 5.00
158 INT23463 Positive_regulation of Gene_expression of CALCA 47 0.70 18.14 28.76 5.00
159 INT15610 Localization of GOPC 223 0.65 68.26 28.7 5.00
160 INT8097 Gene_expression of EGF 122 0.77 75.94 28.47 5.00
161 INT55737 Positive_regulation of MMP2 101 0.68 59.11 27.71 5.00
162 INT703 Positive_regulation of Pth 177 0.70 127.09 27.26 5.00
163 INT17331 Positive_regulation of JUN 132 0.69 60.4 27.03 5.00
164 INT9682 Positive_regulation of IGF1 238 0.70 120.03 26.36 5.00
165 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 5.00
166 INT12124 Gene_expression of MAPK1 141 0.75 82.4 25.58 5.00
167 INT17625 Localization of GCG 210 0.80 55.69 24.97 5.00
168 INT956 Negative_regulation of PRL 94 0.59 42.72 23.01 5.00
169 INT1221 Regulation of SGCG 65 0.60 24.21 22.94 5.00
170 INT3593 Gene_expression of ADRA1D 70 0.75 29.48 20.87 5.00
171 INT14737 Gene_expression of FN1 117 0.78 78.74 18.99 5.00
172 INT1578 Negative_regulation of Localization of PRL 52 0.59 20.62 17.18 5.00
173 INT68681 Transcription of VEGFA 132 0.71 80.47 17.03 5.00
174 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71 5.00
175 INT42810 Gene_expression of CALCRL 53 0.77 10.87 15.42 5.00
176 INT20420 Gene_expression of MYC 99 0.75 49.32 14.36 5.00
177 INT6947 Negative_regulation of Gene_expression of POMC 37 0.59 10.32 14.14 5.00
178 INT69435 Negative_regulation of ROS1 74 0.51 50.38 13.71 5.00
179 INT2005 Positive_regulation of Gene_expression of PRL 55 0.70 21.4 13.44 5.00
180 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32 5.00
181 INT8210 Positive_regulation of Gene_expression of INS 188 0.68 146.57 12.83 5.00
182 INT12156 Positive_regulation of MET 43 0.67 17.75 12.64 5.00
183 INT3040 Gene_expression of MIA3 81 0.24 53.61 12.62 5.00
184 INT63104 Negative_regulation of CALCRL 29 0.37 13.62 12.42 5.00
185 INT69436 Negative_regulation of Gene_expression of ROS1 81 0.38 46.58 12.22 5.00
186 INT112003 Localization of ROS1 94 0.73 66.32 12.16 5.00
187 INT116433 Gene_expression of CYBB 93 0.70 50.44 11.91 5.00
188 INT4605 Negative_regulation of Gene_expression of INS 220 0.58 139.66 10.75 5.00
189 INT94784 Binding of ROS1 113 0.40 71.57 10.26 5.00
190 INT73223 Gene_expression of UPF1 78 0.41 31.44 9.94 5.00
191 INT5465 Positive_regulation of CALCRL 25 0.49 7.24 9.8 5.00
192 INT11729 Regulation of IGF1 71 0.61 44.58 9.71 5.00
193 INT26492 Negative_regulation of Localization of GCG 73 0.58 22.2 9.48 5.00
194 INT6019 Positive_regulation of NEUROD1 37 0.67 17.3 8.89 5.00
195 INT15529 Gene_expression of GCG 51 0.75 18.55 8.35 5.00
196 INT77794 Binding of Gdnf 15 0.48 8.38 8.22 5.00
197 INT108336 Phosphorylation of EPHB2 41 0.80 22.25 8.21 5.00
198 INT16131 Negative_regulation of GBE1 37 0.30 10.32 8.15 5.00
199 INT61363 Positive_regulation of TFAM 43 0.69 26.43 8.14 5.00
200 INT2093 Gene_expression of GAST 50 0.78 32.32 7.98 5.00
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