D:Multiple Endocrine Neoplasia Type 1

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Disease Term
Synonyms Endocrine Adenoma Peptic Ulcer Complex, Mea 1, MEA I, MEA TYPE 1, Men 1 Multiple Endocrine Neoplasia Syndrome Type 1, MEN 1 SYNDROME, Men I, Men Type I, Men1, Multiple Endocrine Type 1 Neoplasms, MULTIPLE ENDOCRINE TYPE I NEOPLASMS
Documents 55
Hot Single Events 81
Hot Interactions 8

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Multiple Endocrine Neoplasia Type 1. They are ordered first by their relevance to Multiple Endocrine Neoplasia Type 1 and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT197809 Binding of MEN1 and VIM 1 0.04 0.52 0 99.16
2 INT197813 Binding of AMBP and MEN1 1 0.00 0.51 0 99.16
3 INT197810 Binding of MEN1 and MUC1 1 0.06 0.47 0 98.12
4 INT197812 Binding of AMBP and RDBP 1 0.00 0.51 0 97.52
5 INT197811 Binding of SMS and SST 1 0.00 0.98 0.21 94.32
6 INT308432 Binding of PDE4A and Aip 1 0.05 3.1 0.05 92.84
7 INT308425 Binding of Pde2a and Aip 1 0.04 1.37 0 92.84
8 INT197808 Binding of MEN1 and NME1 1 0.00 1.81 0 88.12
9 INT308426 Binding of Pde4a and Aip 1 0.02 0.89 0 78.60
10 INT197815 Binding of MEN1 and TGFB1 1 0.16 0.13 0 68.48
11 INT197817 Binding of JUND and MEN1 1 0.18 0.14 0 58.12
12 INT197844 Binding of MEN1 and Nfkb1 1 0.06 0.26 0 57.76
13 INT197816 Binding of MEN1 and NFKB1 1 0.05 0.07 0 48.28
14 INT197814 Binding of MEN1 and RELA 1 0.42 0.07 0 48.28
15 INT243465 Binding of GH1 and GOPC 1 0.02 0.99 0.09 44.72
16 INT156668 Gh Positive_regulation of Igf1 5 0.22 2.07 0.57 5.00
17 INT292814 Binding of VEGFA and Kdr 8 0.18 3.63 0.48 5.00
18 INT239087 Binding of SST and Negative_regulation of Localization of GH1 1 0.19 0.36 0.24 5.00
19 INT215037 Ghrh Regulation of Localization of Igf2 1 0.04 2.12 0.24 5.00
20 INT205057 MMP3 Negative_regulation of MMP2 1 0.35 3.02 0.2 5.00
21 INT205051 MMP3 Negative_regulation of TIMP1 1 0.36 3.02 0.2 5.00
22 INT215034 Gh Regulation of Igf1 1 0.13 0.27 0.13 5.00
23 INT205055 MMP3 Negative_regulation of COL1A2 1 0.32 1.52 0.1 5.00
24 INT243468 Binding of SSTR1 and SSTR5 1 0.05 0.99 0.1 5.00
25 INT243466 POU1F1 Regulation of GH1 1 0.11 1.26 0.08 5.00
26 INT243464 POU1F1 Regulation of PRL 1 0.28 1.26 0.08 5.00
27 INT215036 Gh Positive_regulation of Gene_expression of Trh 1 0.08 1.4 0.06 5.00
28 INT312330 Binding of Kdr and Flt1 1 0.12 0.37 0 5.00
29 INT205046 MUC13 Negative_regulation of Localization of COL17A1 1 0.31 0.62 0 5.00
30 INT205048 MUC13 Negative_regulation of Localization of SLPI 1 0.06 0.61 0 5.00
31 INT205059 MUC13 Negative_regulation of Localization of ROPN1L 1 0.34 0.62 0 5.00
32 INT243467 PCSK1 Positive_regulation of POMC 1 0.08 1.62 0 5.00
33 INT205047 MUC13 Negative_regulation of SLPI 1 0.06 0.61 0 5.00
34 INT205049 LGALS4 Negative_regulation of Localization of MUC13 1 0.34 0.61 0 5.00
35 INT300448 Binding of VEGFA and Flt1 3 0.10 1.93 0 5.00
36 INT205050 LGALS4 Negative_regulation of Localization of ROPN1L 1 0.36 0.62 0 5.00
37 INT215035 Trh Positive_regulation of Gh 1 0.07 0.89 0 5.00
38 INT312331 Binding of Flt1 and Pgf 1 0.08 0.31 0 5.00
39 INT205058 LGALS4 Negative_regulation of Localization of SLPI 1 0.06 0.61 0 5.00
40 INT205045 LGALS4 Negative_regulation of SLPI 1 0.06 0.61 0 5.00
41 INT205056 LGALS4 Negative_regulation of Localization of COL17A1 1 0.32 0.62 0 5.00
42 INT205053 MUC13 Negative_regulation of Localization of LGALS4 1 0.34 0.61 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Multiple Endocrine Neoplasia Type 1. They are ordered first by their pain relevance and then by number of times they were reported in Multiple Endocrine Neoplasia Type 1. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT61102 Gene_expression of MEN1 12 0.78 17.7 0.43 100.00
2 INT300623 Positive_regulation of Men1 1 0.35 10.65 0.57 100.00
3 INT246502 Negative_regulation of Men1 2 0.30 8.9 0.33 100.00
4 INT115423 Gene_expression of Men1 4 0.47 14.08 0.64 100.00
5 INT197832 Localization of MEN1 1 0.80 11.01 0.63 100.00
6 INT300621 Localization of Men1 1 0.56 4.63 0.52 100.00
7 INT197828 Negative_regulation of MEN1 1 0.43 5.06 0.06 100.00
8 INT136531 Binding of Men1 8 0.47 9.62 0.65 100.00
9 INT197842 Gene_expression of PHPT1 1 0.06 5.89 0.16 100.00
10 INT197841 Positive_regulation of MEN1 1 0.41 2.38 0 100.00
11 INT197835 Positive_regulation of Gene_expression of PHPT1 1 0.04 3.17 0.07 100.00
12 INT197836 Positive_regulation of Gene_expression of MEN1 1 0.50 3.16 0.07 100.00
13 INT269017 Negative_regulation of Men1 1 0.39 3.32 0 100.00
14 INT8159 Binding of ELL 7 0.36 12.62 0.84 100.00
15 INT197843 Regulation of Localization of MEN1 1 0.45 0.24 0 100.00
16 INT82650 Gene_expression of Bcl2 312 0.78 211.71 55.03 100.00
17 INT73593 Gene_expression of BAX 173 0.76 147.81 20.94 100.00
18 INT164833 Transcription of Men1 1 0.53 1.25 0.14 100.00
19 INT308431 Gene_expression of CNC 1 0.01 2.84 0.18 99.90
20 INT197839 Negative_regulation of PHPT1 1 0.04 2.88 0.06 99.84
21 INT18462 Positive_regulation of Pgc 29 0.57 22.55 3.24 99.78
22 INT197834 Binding of MEN1 1 0.48 3.32 0 99.74
23 INT1893 Localization of Gh 1041 0.79 340.23 256.58 99.40
24 INT425 Localization of PRL 455 0.81 189.64 144.8 99.40
25 INT252 Localization of GH1 529 0.80 227.4 122.05 99.40
26 INT443 Localization of POMC 1020 0.81 284.52 443.17 99.40
27 INT915 Positive_regulation of PRL 342 0.70 141.96 104.31 99.30
28 INT6514 Positive_regulation of Gene_expression of PTH 28 0.67 30.28 1.37 99.08
29 INT6512 Gene_expression of PTH 103 0.77 76.29 6.33 99.08
30 INT31793 Transcription of Pgc 2 0.52 2.45 0.29 99.00
31 INT2093 Gene_expression of GAST 50 0.78 32.32 7.98 98.78
32 INT812 Localization of INS 1026 0.81 515.6 145.31 98.76
33 INT197827 Regulation of PHPT1 1 0.03 2.54 0.08 98.76
34 INT186142 Gene_expression of Ghrh 45 0.66 34.04 6.94 98.48
35 INT156 Negative_regulation of Prl 542 0.59 131.97 192.24 98.32
36 INT114091 Negative_regulation of Aip 6 0.48 4.16 1.3 98.24
37 INT1579 Gene_expression of PRL 279 0.78 119.2 55.41 97.74
38 INT2243 Localization of GAST 67 0.81 34.54 16.19 97.52
39 INT1578 Negative_regulation of Localization of PRL 52 0.59 20.62 17.18 96.04
40 INT695 Binding of POMC 304 0.48 56.66 126.85 95.88
41 INT29 Negative_regulation of Gast 74 0.59 24.85 24.96 95.68
42 INT91209 Binding of VIM 15 0.36 12.02 0.53 95.52
43 INT8347 Gene_expression of SST 181 0.78 104.59 65.45 95.28
44 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 95.28
45 INT2640 Gene_expression of Pomc 424 0.78 120.72 155.37 94.80
46 INT744 Positive_regulation of PTH 130 0.70 95.02 11.7 93.52
47 INT65058 Binding of Nfkb1 36 0.45 19.87 10.02 93.44
48 INT300622 Binding of Jund 1 0.04 1.57 0 93.44
49 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82 93.00
50 INT15375 Gene_expression of AXL 21 0.65 18.5 3.74 92.56
51 INT205081 Positive_regulation of Gene_expression of AXL 10 0.58 11.27 2.37 92.56
52 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 92.48
53 INT1498 Gene_expression of Gh 521 0.75 220.84 81.16 92.36
54 INT205105 Gene_expression of AXIN2 1 0.74 6.6 0 91.96
55 INT138872 Gene_expression of SPINK5 21 0.58 30.11 4.12 91.84
56 INT205087 Positive_regulation of Gene_expression of ISL1 4 0.26 3.86 0.19 91.44
57 INT30 Gene_expression of Gast 158 0.78 99 41.45 91.32
58 INT172809 Gene_expression of ISL1 33 0.40 21.63 1.12 91.08
59 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 90.84
60 INT15148 Gene_expression of Vip 51 0.77 25.61 18.33 90.56
61 INT38625 Gene_expression of ELL 8 0.58 12.53 1 90.28
62 INT196916 Negative_regulation of Rb1 13 0.42 14.29 0.4 89.52
63 INT2244 Positive_regulation of Localization of GAST 7 0.68 5.28 0.73 89.52
64 INT13897 Localization of Sst 65 0.81 14.91 32.24 89.44
65 INT197840 Binding of NME1 2 0.04 1.14 0.11 89.04
66 INT90350 Gene_expression of Gast 27 0.78 14.07 4.74 87.20
67 INT703 Positive_regulation of Pth 177 0.70 127.09 27.26 86.88
68 INT3448 Positive_regulation of Gh 521 0.69 180.03 161.18 86.80
69 INT528 Gene_expression of Prl 693 0.78 217.18 192.2 86.68
70 INT626 Localization of CALCA 289 0.81 125.39 221.15 85.68
71 INT148671 Gene_expression of Aip 26 0.63 24.32 3.91 85.24
72 INT2732 Gene_expression of VIP 74 0.78 24.57 33.72 84.44
73 INT4853 Regulation of Hrh2 42 0.45 22.34 16.65 84.44
74 INT53487 Gene_expression of TSC1 81 0.58 77.71 7.94 84.32
75 INT5010 Gene_expression of Calca 197 0.78 85.76 118.75 84.00
76 INT9473 Binding of MUC1 66 0.48 46.77 2.36 83.36
77 INT397 Localization of SST 232 0.81 58.05 101.19 82.56
78 INT1894 Negative_regulation of Localization of Gh 168 0.58 64.12 43.56 82.56
79 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 81.68
80 INT180250 Positive_regulation of GLUL 23 0.29 7.57 3.23 81.20
81 INT3214 Localization of Ins1 527 0.80 196.9 79.26 80.24
82 INT8740 Localization of Gcg 65 0.78 19 9.81 79.52
83 INT288 Positive_regulation of Sct 88 0.70 32.83 24.5 79.20
84 INT215026 Positive_regulation of Ppy 1 0.03 1.85 0.16 78.64
85 INT215031 Localization of Ppy 2 0.23 1.73 0.37 78.32
86 INT159 Negative_regulation of Localization of Prl 416 0.59 55.34 171.8 78.12
87 INT158 Localization of Prl 2431 0.81 378.96 952.2 77.68
88 INT5008 Localization of Calca 204 0.81 80.35 125.16 76.40
89 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 75.44
90 INT112166 Localization of Gast 15 0.72 8.86 2.91 74.00
91 INT215029 Negative_regulation of Ghrh 15 0.56 11.37 2.62 72.04
92 INT215025 Negative_regulation of Gene_expression of Ghrh 10 0.41 7.8 0.65 72.04
93 INT90 Localization of Gast 400 0.81 137.67 113 71.52
94 INT169907 Gene_expression of Rb1 25 0.60 21.95 1.32 71.16
95 INT955 Gene_expression of GHRH 126 0.78 59.91 20.74 70.32
96 INT216011 Regulation of TSC2 2 0.26 3.31 0 69.44
97 INT177938 Negative_regulation of NF1 9 0.43 10.3 0.2 68.00
98 INT27269 Localization of Ghrh 29 0.76 15.42 2.19 66.64
99 INT249 Localization of GHRH 215 0.80 78.02 51.87 66.00
100 INT957 Positive_regulation of GHRH 136 0.70 36.84 40.52 66.00
101 INT914 Positive_regulation of GH1 292 0.69 100.7 84.91 66.00
102 INT2848 Localization of ABCA1 23 0.70 10.64 4.73 64.56
103 INT48692 Binding of VEGFA 345 0.48 210.3 21.31 55.84
104 INT112717 Negative_regulation of Binding of VEGFA 21 0.56 11.07 0.99 55.84
105 INT197838 Transcription of MEN1 1 0.69 0.13 0 52.52
106 INT197824 Positive_regulation of Transcription of MEN1 1 0.50 0.13 0 52.52
107 INT197825 Transcription of JUND 2 0.29 0.43 0 51.88
108 INT197829 Positive_regulation of Transcription of JUND 2 0.21 0.82 0 51.88
109 INT93361 Gene_expression of Trp53 208 0.78 175.35 16.65 48.20
110 INT308427 Positive_regulation of MTUS1 1 0.00 1.02 0 46.96
111 INT23030 Positive_regulation of Pth 13 0.61 9.24 0.97 46.16
112 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 40.20
113 INT205083 Positive_regulation of JUP 6 0.49 5.51 0.13 36.48
114 INT18670 Negative_regulation of ABCA1 16 0.54 5.8 3.39 34.72
115 INT70021 Localization of BCL2 23 0.74 21.6 1.09 30.16
116 INT161382 Localization of KRT20 25 0.61 12.97 2.13 29.64
117 INT205099 Positive_regulation of Gene_expression of AXIN2 1 0.48 3.48 0 27.48
118 INT985 Negative_regulation of GH1 213 0.57 89.53 32.39 26.64
119 INT142060 Positive_regulation of Ghrh 15 0.66 7.21 1.83 26.36
120 INT5865 Positive_regulation of Localization of Gh 282 0.69 84.86 93.5 23.84
121 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 19.48
122 INT1624 Gene_expression of Cea 212 0.76 180.44 34.21 19.48
123 INT151032 Localization of Igf1 49 0.76 26.32 5.71 19.48
124 INT10785 Gene_expression of Prl 35 0.78 20.64 6.7 19.36
125 INT239093 Gene_expression of PTTG1 84 0.65 83.94 1.87 17.36
126 INT531 Gene_expression of GH1 376 0.75 193.45 46.24 15.80
127 INT78281 Gene_expression of Krt7 28 0.70 26.77 0.97 15.52
128 INT213741 Gene_expression of Kdr 60 0.75 44.24 5.35 14.32
129 INT260471 Positive_regulation of Gene_expression of Kdr 9 0.61 8.37 0.99 14.32
130 INT125027 Positive_regulation of Kdr 15 0.50 7.73 0.24 14.32
131 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 13.52
132 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 13.52
133 INT239095 Negative_regulation of PTTG1 2 0.32 8.24 0.09 8.56
134 INT308416 Regulation of Gene_expression of Aip 1 0.37 0.77 0 6.08
135 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 5.00
136 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
137 INT7395 Localization of GNRH1 399 0.81 62.88 117.68 5.00
138 INT1438 Localization of Pomc 360 0.81 101.26 116.47 5.00
139 INT170025 Gene_expression of Fig4 588 0.67 183.27 113.32 5.00
140 INT1530 Regulation of Gh 382 0.61 115.96 112.47 5.00
141 INT1497 Negative_regulation of Gh 415 0.59 192.95 74.71 5.00
142 INT253 Regulation of PRL 184 0.62 47.27 65.79 5.00
143 INT1599 Positive_regulation of ADCY1 146 0.67 30.05 64.9 5.00
144 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 5.00
145 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 5.00
146 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 5.00
147 INT5118 Regulation of SST 97 0.62 34.35 51.74 5.00
148 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 5.00
149 INT4345 Gene_expression of Gtf3a 157 0.67 80.75 48.47 5.00
150 INT1322 Positive_regulation of Localization of INS 293 0.70 120.86 45.98 5.00
151 INT170054 Negative_regulation of Gopc 280 0.38 117.89 42.4 5.00
152 INT89 Positive_regulation of Gast 187 0.70 80.49 42.07 5.00
153 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 5.00
154 INT173693 Localization of Gopc 249 0.65 70.49 38.81 5.00
155 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 5.00
156 INT1931 Positive_regulation of Gene_expression of POMC 116 0.70 37.26 38.67 5.00
157 INT12892 Negative_regulation of TIMP1 136 0.58 83.13 36.54 5.00
158 INT14559 Gene_expression of Igf1 254 0.78 112 34.17 5.00
159 INT248 Positive_regulation of Localization of GH1 137 0.69 49.25 32.92 5.00
160 INT691 Binding of SST 67 0.48 24.66 32.67 5.00
161 INT15610 Localization of GOPC 223 0.65 68.26 28.7 5.00
162 INT6624 Gene_expression of Pth 135 0.76 110.27 27.54 5.00
163 INT9682 Positive_regulation of IGF1 238 0.70 120.03 26.36 5.00
164 INT7394 Positive_regulation of Localization of GNRH1 67 0.69 7.22 25.29 5.00
165 INT2614 Gene_expression of CGA 187 0.78 105.89 24.77 5.00
166 INT14556 Positive_regulation of Igf1 105 0.69 52.21 24.04 5.00
167 INT956 Negative_regulation of PRL 94 0.59 42.72 23.01 5.00
168 INT16303 Negative_regulation of Localization of GH1 89 0.59 37.31 22.15 5.00
169 INT34488 Negative_regulation of MMP2 85 0.59 41.98 21.72 5.00
170 INT28951 Negative_regulation of IGF1 133 0.59 75.77 18.9 5.00
171 INT13454 Positive_regulation of Positive_regulation of Gh 49 0.68 14.53 18.49 5.00
172 INT871 Negative_regulation of Gene_expression of Prl 53 0.58 18.89 17.79 5.00
173 INT68681 Transcription of VEGFA 132 0.71 80.47 17.03 5.00
174 INT1767 Positive_regulation of PROC 83 0.67 54.14 17 5.00
175 INT10841 Positive_regulation of Gene_expression of Gh 101 0.59 45.39 16.96 5.00
176 INT170033 Positive_regulation of Gene_expression of Fig4 59 0.43 20.99 16.69 5.00
177 INT28950 Positive_regulation of Gene_expression of IGF1 99 0.69 46.9 16.47 5.00
178 INT36554 Gene_expression of PRSS1 70 0.78 50.25 15.33 5.00
179 INT12891 Negative_regulation of MMP3 41 0.58 17.99 15.06 5.00
180 INT105387 Gene_expression of HIF1A 116 0.77 98.62 14.66 5.00
181 INT65263 Positive_regulation of Gene_expression of Igf1 61 0.69 25.69 14.49 5.00
182 INT22000 Positive_regulation of Sst 25 0.70 14.82 13.6 5.00
183 INT2005 Positive_regulation of Gene_expression of PRL 55 0.70 21.4 13.44 5.00
184 INT105670 Gene_expression of AAVS1 131 0.75 49.24 12.95 5.00
185 INT8210 Positive_regulation of Gene_expression of INS 188 0.68 146.57 12.83 5.00
186 INT28952 Negative_regulation of Gene_expression of IGF1 75 0.58 41.11 12.32 5.00
187 INT8224 Gene_expression of CHGA 73 0.75 53.63 12.31 5.00
188 INT987 Localization of TRH 37 0.78 10.53 11.1 5.00
189 INT10009 Positive_regulation of TRH 31 0.67 8.94 11.03 5.00
190 INT8963 Gene_expression of Trh 25 0.68 7.5 10.97 5.00
191 INT15350 Localization of Prl 22 0.81 6.86 10.74 5.00
192 INT100379 Positive_regulation of HIF1A 69 0.69 57.31 10.4 5.00
193 INT11510 Negative_regulation of Positive_regulation of Gh 28 0.52 12.71 9.16 5.00
194 INT64849 Gene_expression of Ret 24 0.75 14.36 9.1 5.00
195 INT49325 Gene_expression of Cd34 102 0.78 82.75 8.97 5.00
196 INT97649 Gene_expression of Dlat 48 0.66 13.77 8.94 5.00
197 INT6019 Positive_regulation of NEUROD1 37 0.67 17.3 8.89 5.00
198 INT34777 Localization of IGF1 82 0.80 42.68 8.62 5.00
199 INT156827 Localization of MRI1 25 0.65 16.06 8.33 5.00
200 INT6625 Negative_regulation of Pth 96 0.58 57.6 8.24 5.00
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