D:Multiple Endocrine Neoplasia Type 2a

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Disease Term
Synonyms Mea 2a, Mea Ii, MEA IIA, Men 2, Men 2a, Men Ii, Men Iia, Men2a, MULTIPLE ENDOCRINE NEOPLASIA TYPE 2, Multiple Endocrine Neoplasms Type 2a, NEOPLASIA MULTIPLE ENDOCRINE TYPE 2A
Documents 49
Hot Single Events 42
Hot Interactions 4

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Multiple Endocrine Neoplasia Type 2a. They are ordered first by their relevance to Multiple Endocrine Neoplasia Type 2a and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT199159 Binding of RET and Pheo 1 0.04 1.42 0.03 100.00
2 INT258522 Binding of DDR1 and RET 1 0.03 1.05 0.1 98.96
3 INT354469 Binding of SDHC and Sdhb 1 0.08 1.82 0 94.16
4 INT84622 Binding of RERE and KAL1 1 0.00 1.18 0.07 90.56
5 INT258524 IPMK Negative_regulation of KDR 2 0.00 1.98 0 11.16
6 INT258526 IPMK Negative_regulation of BRAF 1 0.01 1.11 0 11.16
7 INT258525 IPMK Negative_regulation of DDR1 2 0.00 1.97 0 11.16
8 INT258521 EGFR Positive_regulation of MMP2 1 0.39 0.91 0.24 5.00
9 INT258565 EGFR Positive_regulation of Meta 1 0.39 0.89 0.23 5.00
10 INT258527 Binding of BRAF and RET 1 0.21 1.49 0.11 5.00
11 INT200213 PAH Positive_regulation of SDHD 1 0.21 2.43 0.1 5.00
12 INT218784 Binding of TCEB2 and VHL 1 0.04 3.81 0.1 5.00
13 INT200212 Binding of EPAS1 and VHL 3 0.06 4.1 0.05 5.00
14 INT291330 Binding of ENO1 and NOTCH1 1 0.03 1.33 0 5.00
15 INT291329 Binding of NOTCH1 and CERS1 1 0.06 1.42 0 5.00
16 INT291335 Positive_regulation of RAF1 Positive_regulation of Phosphorylation of GSK3A 1 0.07 0.88 0 5.00
17 INT258523 Positive_regulation of RAF1 Positive_regulation of Phosphorylation of GSK 1 0.19 0.64 0 5.00
18 INT258528 Binding of NOTCH1 and DLL1 2 0.07 1.6 0 5.00
19 INT258529 Binding of JAG1 and NOTCH1 3 0.06 2.44 0 5.00
20 INT291333 Binding of CSHL1 and NOTCH1 1 0.05 1.16 0 5.00
21 INT291331 Negative_regulation of GSK3A Positive_regulation of Positive_regulation of RAF1 1 0.07 0.94 0 5.00
22 INT218785 Binding of FN1 and VHL 1 0.06 1.12 0 5.00
23 INT258564 Binding of NOTCH1 and Crlf2 1 0.27 0.67 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Multiple Endocrine Neoplasia Type 2a. They are ordered first by their pain relevance and then by number of times they were reported in Multiple Endocrine Neoplasia Type 2a. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT83461 Binding of RET 8 0.47 9.7 0.87 100.00
2 INT109396 Negative_regulation of RET 12 0.42 14.92 1.06 100.00
3 INT79784 Positive_regulation of RET 15 0.57 17.43 0.71 100.00
4 INT8159 Binding of ELL 7 0.36 12.62 0.84 100.00
5 INT66940 Regulation of RET 7 0.52 5.61 0.69 100.00
6 INT8960 Binding of SDHB 9 0.36 9.2 1.68 100.00
7 INT68665 Binding of Vhl 9 0.48 10.3 0.82 100.00
8 INT200216 Binding of SDHD 3 0.37 4.51 0.71 100.00
9 INT149200 Binding of SDHC 2 0.36 1.82 0.18 100.00
10 INT63333 Gene_expression of RET 24 0.76 30.09 2.41 99.88
11 INT3364 Binding of SGCG 87 0.47 31.93 17.24 99.80
12 INT9292 Positive_regulation of SGCG 93 0.67 35.13 23.48 99.80
13 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 99.18
14 INT140116 Binding of Sdhd 2 0.04 2.78 0.3 99.08
15 INT199146 Gene_expression of Pheo 3 0.18 3.57 1.63 98.92
16 INT58918 Gene_expression of SDHB 5 0.75 2.93 1.27 98.92
17 INT212652 Gene_expression of SDHC 1 0.40 0.73 0.43 98.80
18 INT171435 Gene_expression of SDHD 14 0.58 26.55 0.91 98.60
19 INT192337 Positive_regulation of DDR1 11 0.41 10.34 2.38 98.50
20 INT44746 Localization of Ret 3 0.48 1.23 1.28 97.96
21 INT64849 Gene_expression of Ret 24 0.75 14.36 9.1 97.96
22 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 97.52
23 INT29635 Localization of Eno2 9 0.76 6.05 1.35 97.12
24 INT300623 Positive_regulation of Men1 1 0.35 10.65 0.57 96.80
25 INT703 Positive_regulation of Pth 177 0.70 127.09 27.26 95.92
26 INT744 Positive_regulation of PTH 130 0.70 95.02 11.7 95.72
27 INT200222 Positive_regulation of Localization of SDHD 1 0.43 7.07 0.84 95.44
28 INT246502 Negative_regulation of Men1 2 0.30 8.9 0.33 94.56
29 INT200218 Localization of SDHD 1 0.69 48.58 4.57 93.48
30 INT199153 Phosphorylation of RET 1 0.44 1.73 0.04 92.56
31 INT2541 Binding of Calca 200 0.48 67.14 134.62 89.00
32 INT2542 Localization of Calca 2008 0.81 518.3 1408.65 88.88
33 INT84623 Binding of KAL1 1 0.02 1.16 0.06 88.88
34 INT2543 Positive_regulation of Calca 787 0.70 331.13 592.08 88.40
35 INT77794 Binding of Gdnf 15 0.48 8.38 8.22 86.84
36 INT48312 Gene_expression of NTRK1 72 0.78 38.21 22.24 85.16
37 INT1931 Positive_regulation of Gene_expression of POMC 116 0.70 37.26 38.67 84.88
38 INT191253 Negative_regulation of DDR1 13 0.25 10.05 1.05 81.72
39 INT52053 Positive_regulation of Positive_regulation of SDHB 2 0.49 3.11 0.14 81.60
40 INT52052 Positive_regulation of SDHB 14 0.68 14.07 2.27 81.32
41 INT66941 Localization of NTRK1 8 0.78 5.89 1.96 81.04
42 INT11551 Localization of VHL 12 0.65 22.76 0.68 80.20
43 INT152200 Positive_regulation of Pheo 3 0.11 1.59 0.52 79.92
44 INT16277 Regulation of CHGA 16 0.44 11.31 4.43 76.88
45 INT132885 Regulation of SYP 4 0.44 3.92 0.44 76.88
46 INT66041 Positive_regulation of NTRK1 24 0.70 16.12 8.42 76.28
47 INT3300 Positive_regulation of Gene_expression of Calca 179 0.70 77.76 144.2 75.00
48 INT671 Positive_regulation of Cea 221 0.69 164.5 47.79 75.00
49 INT1624 Gene_expression of Cea 212 0.76 180.44 34.21 75.00
50 INT185017 Gene_expression of TOP2B 7 0.75 4.84 1.67 68.00
51 INT121496 Gene_expression of TERT 107 0.78 45.6 7.42 65.52
52 INT67195 Negative_regulation of Gene_expression of SST 7 0.42 6.98 4.88 64.36
53 INT8347 Gene_expression of SST 181 0.78 104.59 65.45 63.96
54 INT691 Binding of SST 67 0.48 24.66 32.67 60.68
55 INT24876 Gene_expression of CD34 172 0.78 91.02 12.39 56.16
56 INT69264 Gene_expression of KIT 207 0.78 179.41 8.95 56.16
57 INT4988 Gene_expression of KRT1 64 0.77 43.4 4.12 56.16
58 INT208125 Gene_expression of DDR1 10 0.06 8.15 1.03 52.08
59 INT2867 Gene_expression of CALCA 247 0.78 78.78 138.47 44.72
60 INT329916 Localization of Pgls 1 0.61 1.33 0.07 44.08
61 INT74017 Regulation of VHL 4 0.43 7.59 0.16 41.16
62 INT6514 Positive_regulation of Gene_expression of PTH 28 0.67 30.28 1.37 39.32
63 INT6512 Gene_expression of PTH 103 0.77 76.29 6.33 38.92
64 INT9110 Binding of PAH 32 0.41 42.1 3.1 32.64
65 INT200217 Localization of PAH 10 0.36 15.51 2.46 29.48
66 INT56925 Negative_regulation of TSC1 54 0.52 63.39 1.87 25.12
67 INT62684 Negative_regulation of TP53 66 0.58 66.09 4.62 23.76
68 INT173086 Negative_regulation of VHL 14 0.59 12.54 0.29 12.56
69 INT136503 Negative_regulation of KDR 46 0.48 43.1 1.86 10.68
70 INT258556 Negative_regulation of BRAF 4 0.42 2.48 0.03 10.68
71 INT60279 Gene_expression of VHL 70 0.78 75.21 2.21 10.04
72 INT156827 Localization of MRI1 25 0.65 16.06 8.33 8.88
73 INT258548 Positive_regulation of Meta 10 0.67 5.05 1.42 7.84
74 INT258549 Regulation of Positive_regulation of Meta 3 0.44 2.31 0.4 7.84
75 INT19795 Positive_regulation of EGFR 161 0.70 103.69 11.55 6.64
76 INT145155 Regulation of Positive_regulation of EGFR 6 0.38 4.54 0.33 6.64
77 INT158 Localization of Prl 2431 0.81 378.96 952.2 5.00
78 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82 5.00
79 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
80 INT1893 Localization of Gh 1041 0.79 340.23 256.58 5.00
81 INT626 Localization of CALCA 289 0.81 125.39 221.15 5.00
82 INT6665 Gene_expression of FOS 520 0.77 165.31 217.66 5.00
83 INT528 Gene_expression of Prl 693 0.78 217.18 192.2 5.00
84 INT159 Negative_regulation of Localization of Prl 416 0.59 55.34 171.8 5.00
85 INT2640 Gene_expression of Pomc 424 0.78 120.72 155.37 5.00
86 INT397 Localization of SST 232 0.81 58.05 101.19 5.00
87 INT4860 Positive_regulation of CALCA 148 0.00 73.35 97.61 5.00
88 INT17459 Positive_regulation of Gene_expression of FOS 182 0.67 53.45 96.38 5.00
89 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 5.00
90 INT1498 Gene_expression of Gh 521 0.75 220.84 81.16 5.00
91 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 5.00
92 INT4241 Regulation of CALCA 87 0.62 28.19 55.29 5.00
93 INT8490 Negative_regulation of CALCA 87 0.59 29.73 51.34 5.00
94 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 5.00
95 INT1894 Negative_regulation of Localization of Gh 168 0.58 64.12 43.56 5.00
96 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 5.00
97 INT67613 Positive_regulation of PPARG 94 0.70 69.15 34.38 5.00
98 INT48693 Regulation of VEGFA 268 0.62 191.88 31.52 5.00
99 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 5.00
100 INT8097 Gene_expression of EGF 122 0.77 75.94 28.47 5.00
101 INT55737 Positive_regulation of MMP2 101 0.68 59.11 27.71 5.00
102 INT17331 Positive_regulation of JUN 132 0.69 60.4 27.03 5.00
103 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 5.00
104 INT12124 Gene_expression of MAPK1 141 0.75 82.4 25.58 5.00
105 INT3593 Gene_expression of ADRA1D 70 0.75 29.48 20.87 5.00
106 INT68681 Transcription of VEGFA 132 0.71 80.47 17.03 5.00
107 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71 5.00
108 INT42810 Gene_expression of CALCRL 53 0.77 10.87 15.42 5.00
109 INT20420 Gene_expression of MYC 99 0.75 49.32 14.36 5.00
110 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32 5.00
111 INT63104 Negative_regulation of CALCRL 29 0.37 13.62 12.42 5.00
112 INT65058 Binding of Nfkb1 36 0.45 19.87 10.02 5.00
113 INT5465 Positive_regulation of CALCRL 25 0.49 7.24 9.8 5.00
114 INT6810 Gene_expression of ENO2 70 0.78 54.8 8.35 5.00
115 INT108336 Phosphorylation of EPHB2 41 0.80 22.25 8.21 5.00
116 INT57748 Positive_regulation of Gene_expression of TP53 85 0.69 79.55 7.49 5.00
117 INT14732 Positive_regulation of FN1 46 0.69 31.17 7.33 5.00
118 INT96994 Phosphorylation of EGFR 99 0.82 52.75 7.33 5.00
119 INT11154 Binding of EGFR 149 0.48 96.23 6.29 5.00
120 INT71151 Regulation of NTRK1 10 0.62 6.65 6.21 5.00
121 INT48313 Binding of NTRK1 19 0.47 14.44 6.12 5.00
122 INT71152 Negative_regulation of NTRK1 15 0.59 10.28 5.5 5.00
123 INT21609 Positive_regulation of RASGRP1 58 0.50 40.78 5.47 5.00
124 INT15652 Positive_regulation of ENO2 37 0.68 33.39 5.02 5.00
125 INT11158 Positive_regulation of Gene_expression of EGFR 165 0.70 131.26 4.93 5.00
126 INT141000 Negative_regulation of GSK 24 0.57 9.46 4.4 5.00
127 INT67936 Transcription of JUN 18 0.52 9.52 4.13 5.00
128 INT40036 Binding of DLL1 10 0.36 2.88 3.95 5.00
129 INT19158 Gene_expression of PAH 35 0.65 35.81 3.88 5.00
130 INT122323 Positive_regulation of NOTCH1 36 0.70 35.63 3.7 5.00
131 INT8096 Positive_regulation of Gene_expression of EGF 21 0.69 13.43 3.47 5.00
132 INT79270 Gene_expression of MKI67 113 0.77 63.52 3.38 5.00
133 INT61500 Binding of FN1 39 0.48 27.33 3.13 5.00
134 INT73263 Negative_regulation of MYC 20 0.57 12.86 2.95 5.00
135 INT27652 Gene_expression of TG 36 0.78 22.36 2.74 5.00
136 INT119518 Positive_regulation of Gene_expression of NTRK1 5 0.67 3.47 2.66 5.00
137 INT119025 Gene_expression of NOTCH1 46 0.75 31.32 2.64 5.00
138 INT36923 Binding of Mdk 7 0.35 3.81 2.58 5.00
139 INT127458 Positive_regulation of PAH 24 0.58 27.25 2.53 5.00
140 INT1921 Gene_expression of CEACAM7 47 0.78 43.23 2.53 5.00
141 INT287307 Binding of ENO1 9 0.48 11.24 2.51 5.00
142 INT114327 Positive_regulation of RAF1 26 0.51 20.87 2.32 5.00
143 INT55736 Transcription of MMP2 11 0.68 5.78 2.28 5.00
144 INT85284 Negative_regulation of ENO2 8 0.58 7.86 2.28 5.00
145 INT121589 Negative_regulation of GSK3A 10 0.53 9.11 2.22 5.00
146 INT109327 Negative_regulation of KIT 42 0.57 43.2 2.15 5.00
147 INT73476 Transcription of MYC 18 0.69 12.14 2.13 5.00
148 INT291336 Gene_expression of MAP2K6 4 0.70 7.8 2.13 5.00
149 INT201683 Phosphorylation of GSK 15 0.80 6.6 2.01 5.00
150 INT20421 Positive_regulation of MYC 19 0.67 10.43 1.9 5.00
151 INT21487 Negative_regulation of HCC 18 0.49 29.81 1.88 5.00
152 INT79140 Binding of HCC 36 0.31 46.96 1.87 5.00
153 INT200223 Positive_regulation of EPAS1 21 0.17 21.95 1.7 5.00
154 INT73475 Positive_regulation of Transcription of MYC 7 0.67 5.46 1.66 5.00
155 INT86368 Gene_expression of TEP1 31 0.50 16.36 1.63 5.00
156 INT43637 Positive_regulation of AXL 11 0.58 11.71 1.59 5.00
157 INT78097 Negative_regulation of Regulation of CALCA 2 0.42 2.02 1.37 5.00
158 INT95939 Positive_regulation of GSK 19 0.67 10 1.33 5.00
159 INT85047 Positive_regulation of Negative_regulation of NTRK1 3 0.47 2.13 1.3 5.00
160 INT152255 Gene_expression of ATM 14 0.71 12.53 1.26 5.00
161 INT19520 Negative_regulation of SDHB 4 0.37 1.57 1.24 5.00
162 INT61993 Gene_expression of NF1 29 0.78 34.47 1.23 5.00
163 INT149292 Localization of NOTCH1 7 0.54 6.11 1.14 5.00
164 INT149838 Binding of TSHB 5 0.14 3.27 1.1 5.00
165 INT35104 Positive_regulation of GC 6 0.11 4.99 1.08 5.00
166 INT55794 Binding of Crlf2 5 0.36 0.68 1.05 5.00
167 INT67097 Gene_expression of MIB1 20 0.75 21.06 1.03 5.00
168 INT132521 Gene_expression of BRAF 14 0.65 13.59 0.73 5.00
169 INT183672 Gene_expression of EPAS1 37 0.35 28.68 0.72 5.00
170 INT89428 Regulation of TG 6 0.36 3.93 0.72 5.00
171 INT114842 Localization of RET 3 0.71 5.98 0.71 5.00
172 INT114246 Positive_regulation of Negative_regulation of EGFR 13 0.49 8.67 0.7 5.00
173 INT143953 Regulation of Positive_regulation of MMP2 3 0.44 2.25 0.69 5.00
174 INT200219 Positive_regulation of VHL 18 0.50 15.38 0.67 5.00
175 INT115423 Gene_expression of Men1 4 0.47 14.08 0.64 5.00
176 INT136920 Positive_regulation of Gene_expression of NOTCH1 12 0.49 8.25 0.59 5.00
177 INT175995 Gene_expression of HEPACAM 12 0.28 12.45 0.58 5.00
178 INT48212 Binding of ATM 5 0.47 3.89 0.57 5.00
179 INT74016 Binding of VHL 20 0.48 15.49 0.54 5.00
180 INT300621 Localization of Men1 1 0.56 4.63 0.52 5.00
181 INT49676 Positive_regulation of TG 10 0.48 9.09 0.44 5.00
182 INT252737 Gene_expression of RAF1 12 0.58 10.97 0.42 5.00
183 INT200221 Positive_regulation of SDHD 3 0.43 6.59 0.42 5.00
184 INT151400 Binding of JAG1 14 0.37 7.96 0.39 5.00
185 INT175997 Localization of HEPACAM 6 0.31 5.91 0.39 5.00
186 INT156655 Positive_regulation of Pgls 2 0.38 3.11 0.35 5.00
187 INT45730 Transcription of PAH 3 0.68 2.4 0.33 5.00
188 INT84923 Transcription of NTRK1 2 0.67 1.65 0.33 5.00
189 INT186115 Negative_regulation of Negative_regulation of EGFR 5 0.57 3.42 0.33 5.00
190 INT236623 Positive_regulation of BRAF 3 0.45 2.05 0.32 5.00
191 INT156165 Regulation of Gene_expression of NTRK1 2 0.37 1.91 0.27 5.00
192 INT164294 Negative_regulation of Gene_expression of ENO2 2 0.41 1.36 0.27 5.00
193 INT89427 Localization of TG 5 0.79 2.4 0.26 5.00
194 INT130099 Negative_regulation of Positive_regulation of NOTCH1 4 0.43 2.56 0.21 5.00
195 INT252745 Positive_regulation of Positive_regulation of RAF1 3 0.20 4.62 0.21 5.00
196 INT94668 Negative_regulation of Binding of FN1 5 0.58 4.44 0.18 5.00
197 INT200220 Positive_regulation of Positive_regulation of EPAS1 2 0.09 2 0.16 5.00
198 INT127806 Negative_regulation of ASCL1 6 0.45 5.85 0.16 5.00
199 INT200215 Transcription of SDHD 1 0.59 1.35 0.15 5.00
200 INT61499 Positive_regulation of Binding of FN1 2 0.46 1.99 0.14 5.00
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