D:Multiple Endocrine Neoplasia Type 2b

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Disease Term
Synonyms Mea 2b, Mea Iib, MEN 2B, Men 3, Men Iib, Men Iii, Men2b, MUCOSAL NEUROMA SYNDROME, Multiple Endocrine Neoplasms Type 2b, Neoplasia Multiple Endocrine Type 2b, NEOPLASMS MULTIPLE ENDOCRINE TYPE 2B
Documents 25
Hot Single Events 15
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Multiple Endocrine Neoplasia Type 2b. They are ordered first by their relevance to Multiple Endocrine Neoplasia Type 2b and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT199159 Binding of RET and Pheo 1 0.04 1.42 0.03 60.32
2 INT258524 IPMK Negative_regulation of KDR 2 0.00 1.98 0 49.32
3 INT258526 IPMK Negative_regulation of BRAF 1 0.01 1.11 0 49.32
4 INT258525 IPMK Negative_regulation of DDR1 2 0.00 1.97 0 49.32
5 INT258522 Binding of DDR1 and RET 1 0.03 1.05 0.1 34.16
6 INT258521 EGFR Positive_regulation of MMP2 1 0.39 0.91 0.24 5.00
7 INT258565 EGFR Positive_regulation of Meta 1 0.39 0.89 0.23 5.00
8 INT258527 Binding of BRAF and RET 1 0.21 1.49 0.11 5.00
9 INT291330 Binding of ENO1 and NOTCH1 1 0.03 1.33 0 5.00
10 INT291329 Binding of NOTCH1 and CERS1 1 0.06 1.42 0 5.00
11 INT291335 Positive_regulation of RAF1 Positive_regulation of Phosphorylation of GSK3A 1 0.07 0.88 0 5.00
12 INT258523 Positive_regulation of RAF1 Positive_regulation of Phosphorylation of GSK 1 0.19 0.64 0 5.00
13 INT258528 Binding of NOTCH1 and DLL1 2 0.07 1.6 0 5.00
14 INT258529 Binding of JAG1 and NOTCH1 3 0.06 2.44 0 5.00
15 INT291333 Binding of CSHL1 and NOTCH1 1 0.05 1.16 0 5.00
16 INT291331 Negative_regulation of GSK3A Positive_regulation of Positive_regulation of RAF1 1 0.07 0.94 0 5.00
17 INT258564 Binding of NOTCH1 and Crlf2 1 0.27 0.67 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Multiple Endocrine Neoplasia Type 2b. They are ordered first by their pain relevance and then by number of times they were reported in Multiple Endocrine Neoplasia Type 2b. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT109396 Negative_regulation of RET 12 0.42 14.92 1.06 100.00
2 INT8159 Binding of ELL 7 0.36 12.62 0.84 100.00
3 INT83461 Binding of RET 8 0.47 9.7 0.87 100.00
4 INT66940 Regulation of RET 7 0.52 5.61 0.69 100.00
5 INT199146 Gene_expression of Pheo 3 0.18 3.57 1.63 99.32
6 INT2541 Binding of Calca 200 0.48 67.14 134.62 98.40
7 INT79784 Positive_regulation of RET 15 0.57 17.43 0.71 95.04
8 INT2543 Positive_regulation of Calca 787 0.70 331.13 592.08 94.60
9 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 94.36
10 INT2542 Localization of Calca 2008 0.81 518.3 1408.65 93.24
11 INT199153 Phosphorylation of RET 1 0.44 1.73 0.04 92.64
12 INT38625 Gene_expression of ELL 8 0.58 12.53 1 87.88
13 INT48312 Gene_expression of NTRK1 72 0.78 38.21 22.24 85.44
14 INT191253 Negative_regulation of DDR1 13 0.25 10.05 1.05 83.60
15 INT66941 Localization of NTRK1 8 0.78 5.89 1.96 80.76
16 INT64849 Gene_expression of Ret 24 0.75 14.36 9.1 78.56
17 INT66041 Positive_regulation of NTRK1 24 0.70 16.12 8.42 78.36
18 INT703 Positive_regulation of Pth 177 0.70 127.09 27.26 51.12
19 INT744 Positive_regulation of PTH 130 0.70 95.02 11.7 51.12
20 INT136503 Negative_regulation of KDR 46 0.48 43.1 1.86 48.84
21 INT258556 Negative_regulation of BRAF 4 0.42 2.48 0.03 48.84
22 INT2867 Gene_expression of CALCA 247 0.78 78.78 138.47 40.56
23 INT258550 Negative_regulation of Negative_regulation of Ulbp1 1 0.41 1.23 0 40.56
24 INT258546 Negative_regulation of Ulbp1 1 0.41 1.1 0 40.56
25 INT152200 Positive_regulation of Pheo 3 0.11 1.59 0.52 37.92
26 INT44746 Localization of Ret 3 0.48 1.23 1.28 34.56
27 INT192337 Positive_regulation of DDR1 11 0.41 10.34 2.38 34.16
28 INT11154 Binding of EGFR 149 0.48 96.23 6.29 33.24
29 INT63333 Gene_expression of RET 24 0.76 30.09 2.41 32.16
30 INT8097 Gene_expression of EGF 122 0.77 75.94 28.47 22.92
31 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 22.92
32 INT11158 Positive_regulation of Gene_expression of EGFR 165 0.70 131.26 4.93 22.92
33 INT8096 Positive_regulation of Gene_expression of EGF 21 0.69 13.43 3.47 22.92
34 INT77794 Binding of Gdnf 15 0.48 8.38 8.22 17.32
35 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
36 INT626 Localization of CALCA 289 0.81 125.39 221.15 5.00
37 INT6665 Gene_expression of FOS 520 0.77 165.31 217.66 5.00
38 INT4860 Positive_regulation of CALCA 148 0.00 73.35 97.61 5.00
39 INT17459 Positive_regulation of Gene_expression of FOS 182 0.67 53.45 96.38 5.00
40 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 5.00
41 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 5.00
42 INT4241 Regulation of CALCA 87 0.62 28.19 55.29 5.00
43 INT8490 Negative_regulation of CALCA 87 0.59 29.73 51.34 5.00
44 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 5.00
45 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 5.00
46 INT67613 Positive_regulation of PPARG 94 0.70 69.15 34.38 5.00
47 INT1624 Gene_expression of Cea 212 0.76 180.44 34.21 5.00
48 INT48693 Regulation of VEGFA 268 0.62 191.88 31.52 5.00
49 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 5.00
50 INT55737 Positive_regulation of MMP2 101 0.68 59.11 27.71 5.00
51 INT17331 Positive_regulation of JUN 132 0.69 60.4 27.03 5.00
52 INT12124 Gene_expression of MAPK1 141 0.75 82.4 25.58 5.00
53 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71 5.00
54 INT42810 Gene_expression of CALCRL 53 0.77 10.87 15.42 5.00
55 INT20420 Gene_expression of MYC 99 0.75 49.32 14.36 5.00
56 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32 5.00
57 INT63104 Negative_regulation of CALCRL 29 0.37 13.62 12.42 5.00
58 INT19795 Positive_regulation of EGFR 161 0.70 103.69 11.55 5.00
59 INT5465 Positive_regulation of CALCRL 25 0.49 7.24 9.8 5.00
60 INT108336 Phosphorylation of EPHB2 41 0.80 22.25 8.21 5.00
61 INT57748 Positive_regulation of Gene_expression of TP53 85 0.69 79.55 7.49 5.00
62 INT96994 Phosphorylation of EGFR 99 0.82 52.75 7.33 5.00
63 INT71151 Regulation of NTRK1 10 0.62 6.65 6.21 5.00
64 INT48313 Binding of NTRK1 19 0.47 14.44 6.12 5.00
65 INT71152 Negative_regulation of NTRK1 15 0.59 10.28 5.5 5.00
66 INT21609 Positive_regulation of RASGRP1 58 0.50 40.78 5.47 5.00
67 INT62684 Negative_regulation of TP53 66 0.58 66.09 4.62 5.00
68 INT141000 Negative_regulation of GSK 24 0.57 9.46 4.4 5.00
69 INT67936 Transcription of JUN 18 0.52 9.52 4.13 5.00
70 INT40036 Binding of DLL1 10 0.36 2.88 3.95 5.00
71 INT122323 Positive_regulation of NOTCH1 36 0.70 35.63 3.7 5.00
72 INT73263 Negative_regulation of MYC 20 0.57 12.86 2.95 5.00
73 INT27652 Gene_expression of TG 36 0.78 22.36 2.74 5.00
74 INT119518 Positive_regulation of Gene_expression of NTRK1 5 0.67 3.47 2.66 5.00
75 INT119025 Gene_expression of NOTCH1 46 0.75 31.32 2.64 5.00
76 INT36923 Binding of Mdk 7 0.35 3.81 2.58 5.00
77 INT1921 Gene_expression of CEACAM7 47 0.78 43.23 2.53 5.00
78 INT287307 Binding of ENO1 9 0.48 11.24 2.51 5.00
79 INT183668 Binding of SGCA 15 0.36 9.86 2.42 5.00
80 INT114327 Positive_regulation of RAF1 26 0.51 20.87 2.32 5.00
81 INT121589 Negative_regulation of GSK3A 10 0.53 9.11 2.22 5.00
82 INT109327 Negative_regulation of KIT 42 0.57 43.2 2.15 5.00
83 INT73476 Transcription of MYC 18 0.69 12.14 2.13 5.00
84 INT291336 Gene_expression of MAP2K6 4 0.70 7.8 2.13 5.00
85 INT201683 Phosphorylation of GSK 15 0.80 6.6 2.01 5.00
86 INT20421 Positive_regulation of MYC 19 0.67 10.43 1.9 5.00
87 INT21487 Negative_regulation of HCC 18 0.49 29.81 1.88 5.00
88 INT56925 Negative_regulation of TSC1 54 0.52 63.39 1.87 5.00
89 INT79140 Binding of HCC 36 0.31 46.96 1.87 5.00
90 INT73475 Positive_regulation of Transcription of MYC 7 0.67 5.46 1.66 5.00
91 INT43637 Positive_regulation of AXL 11 0.58 11.71 1.59 5.00
92 INT258548 Positive_regulation of Meta 10 0.67 5.05 1.42 5.00
93 INT78097 Negative_regulation of Regulation of CALCA 2 0.42 2.02 1.37 5.00
94 INT95939 Positive_regulation of GSK 19 0.67 10 1.33 5.00
95 INT85047 Positive_regulation of Negative_regulation of NTRK1 3 0.47 2.13 1.3 5.00
96 INT152255 Gene_expression of ATM 14 0.71 12.53 1.26 5.00
97 INT149292 Localization of NOTCH1 7 0.54 6.11 1.14 5.00
98 INT149838 Binding of TSHB 5 0.14 3.27 1.1 5.00
99 INT35104 Positive_regulation of GC 6 0.11 4.99 1.08 5.00
100 INT55794 Binding of Crlf2 5 0.36 0.68 1.05 5.00
101 INT208125 Gene_expression of DDR1 10 0.06 8.15 1.03 5.00
102 INT132521 Gene_expression of BRAF 14 0.65 13.59 0.73 5.00
103 INT89428 Regulation of TG 6 0.36 3.93 0.72 5.00
104 INT114246 Positive_regulation of Negative_regulation of EGFR 13 0.49 8.67 0.7 5.00
105 INT143953 Regulation of Positive_regulation of MMP2 3 0.44 2.25 0.69 5.00
106 INT136920 Positive_regulation of Gene_expression of NOTCH1 12 0.49 8.25 0.59 5.00
107 INT175995 Gene_expression of HEPACAM 12 0.28 12.45 0.58 5.00
108 INT48212 Binding of ATM 5 0.47 3.89 0.57 5.00
109 INT190309 Localization of SGCA 3 0.20 1.94 0.45 5.00
110 INT49676 Positive_regulation of TG 10 0.48 9.09 0.44 5.00
111 INT252737 Gene_expression of RAF1 12 0.58 10.97 0.42 5.00
112 INT258549 Regulation of Positive_regulation of Meta 3 0.44 2.31 0.4 5.00
113 INT151400 Binding of JAG1 14 0.37 7.96 0.39 5.00
114 INT175997 Localization of HEPACAM 6 0.31 5.91 0.39 5.00
115 INT84923 Transcription of NTRK1 2 0.67 1.65 0.33 5.00
116 INT186115 Negative_regulation of Negative_regulation of EGFR 5 0.57 3.42 0.33 5.00
117 INT145155 Regulation of Positive_regulation of EGFR 6 0.38 4.54 0.33 5.00
118 INT236623 Positive_regulation of BRAF 3 0.45 2.05 0.32 5.00
119 INT156165 Regulation of Gene_expression of NTRK1 2 0.37 1.91 0.27 5.00
120 INT89427 Localization of TG 5 0.79 2.4 0.26 5.00
121 INT130099 Negative_regulation of Positive_regulation of NOTCH1 4 0.43 2.56 0.21 5.00
122 INT252745 Positive_regulation of Positive_regulation of RAF1 3 0.20 4.62 0.21 5.00
123 INT127806 Negative_regulation of ASCL1 6 0.45 5.85 0.16 5.00
124 INT185264 Gene_expression of ASCL1 3 0.50 2.04 0.13 5.00
125 INT256427 Negative_regulation of TG 3 0.42 1.84 0.12 5.00
126 INT259745 Phosphorylation of GSK3A 6 0.20 3 0.11 5.00
127 INT211679 Positive_regulation of HEPACAM 6 0.02 8.25 0.11 5.00
128 INT258561 Negative_regulation of Negative_regulation of KDR 1 0.11 0.91 0.09 5.00
129 INT150959 Gene_expression of BCO2 4 0.25 2.21 0.08 5.00
130 INT338101 Positive_regulation of Gene_expression of BCO2 1 0.23 1.32 0.08 5.00
131 INT190308 Positive_regulation of Localization of SGCA 1 0.13 1.22 0.06 5.00
132 INT224326 Binding of RAF1 3 0.13 3.11 0.05 5.00
133 INT338103 Negative_regulation of ZNF706 1 0.04 1.15 0 5.00
134 INT291339 Binding of CSHL1 1 0.07 2.19 0 5.00
135 INT258547 Binding of Ephb2 2 0.35 1.61 0 5.00
136 INT158132 Negative_regulation of IPMK 2 0.02 1.54 0 5.00
137 INT258560 Binding of NONO 1 0.03 1.06 0 5.00
138 INT338104 Transcription of RET 1 0.54 0.59 0 5.00
139 INT217179 Negative_regulation of AXL 2 0.01 1.9 0 5.00
140 INT291322 Negative_regulation of Chga 1 0.42 2.53 0 5.00
141 INT338102 Binding of CA4 1 0.01 1.07 0 5.00
142 INT258553 Binding of RBPJ 1 0.11 1.06 0 5.00
143 INT291337 Negative_regulation of Positive_regulation of AXL 1 0.00 0.79 0 5.00
144 INT255168 Binding of CERS1 2 0.07 1.85 0 5.00
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