D:Multiple Hereditary Exostoses

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Disease Term
Synonyms Aclases Diaphyseal, Aclasis Diaphyseal, Cartilaginous Exostoses Multiple, Cartilaginous Exostosis Multiple, Chondrodysplasia Hereditary Deforming, CHONDRODYSPLASIAS HEREDITARY DEFORMING, Deforming Chondrodysplasia Hereditary, Deforming Chondrodysplasias Hereditary, Diaphyseal Aclases, Diaphyseal Aclasis, Exostoses Familial
Documents 53
Hot Single Events 23
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Multiple Hereditary Exostoses. They are ordered first by their relevance to Multiple Hereditary Exostoses and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT150351 Binding of EXT1 and MMP12 1 0.04 3.68 0.29 100.00
2 INT324053 Binding of Banf1 and Lemd3 1 0.20 0.15 0 50.00
3 INT301365 Stat1 Positive_regulation of Cdkn1a 1 0.03 0.38 0 50.00
4 INT301364 Stat1 Positive_regulation of Cdkn1a 1 0.03 0.39 0 50.00
5 INT301366 Fgf18 Positive_regulation of Fgfr3 1 0.04 0.34 0 50.00
6 INT197794 Negative_regulation of Pthlh Regulation of Ihh 1 0.36 1.33 0 5.00
7 INT197793 Pthlh Regulation of Ihh 1 0.22 1.32 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Multiple Hereditary Exostoses. They are ordered first by their pain relevance and then by number of times they were reported in Multiple Hereditary Exostoses. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT85941 Binding of MMP12 3 0.31 4.91 1.12 100.00
2 INT20492 Gene_expression of MMP12 89 0.76 81.36 46.12 100.00
3 INT23635 Positive_regulation of MMP12 31 0.59 28.19 17.95 100.00
4 INT140858 Negative_regulation of SUGT1 9 0.05 8.41 1.4 99.80
5 INT301355 Binding of Ext1 2 0.37 4.07 0.03 99.70
6 INT324047 Binding of Lemd3 1 0.48 3.18 0 99.66
7 INT1878 Binding of HLA-B 440 0.48 321.16 127.36 97.48
8 INT228614 Negative_regulation of EXT1 1 0.58 0.86 0 96.64
9 INT301360 Gene_expression of Ext1 3 0.68 1.01 0 95.40
10 INT147079 Gene_expression of Ext2 2 0.66 1.04 0.1 95.40
11 INT301354 Transcription of Ext1 1 0.46 1 0 89.36
12 INT112883 Gene_expression of Hspg2 22 0.65 6.54 4.95 85.24
13 INT228620 Transcription of EXT1 3 0.71 2.67 0 85.20
14 INT324041 Localization of Mro 1 0.33 1.48 0 84.96
15 INT228617 Transcription of EXT2 1 0.69 1.56 0 84.84
16 INT238768 Localization of BHLHE40 1 0.01 0.33 0 82.80
17 INT228621 Positive_regulation of Gene_expression of EXT2 1 0.49 0.78 0 82.76
18 INT228612 Positive_regulation of Gene_expression of EXT1 2 0.50 1.48 0 82.76
19 INT228622 Positive_regulation of Transcription of EXT1 1 0.46 0.78 0 82.76
20 INT228619 Positive_regulation of EXT2 1 0.49 0.78 0 82.76
21 INT167842 Positive_regulation of EXT1 5 0.50 2.88 0 82.76
22 INT228615 Gene_expression of EXT2 1 0.66 1.55 0 82.40
23 INT228618 Gene_expression of EXT1 4 0.77 3.7 0 82.40
24 INT140984 Regulation of Ihh 5 0.54 2.81 0.56 78.40
25 INT324046 Gene_expression of Lemd3 1 0.67 1.69 0.1 77.92
26 INT93361 Gene_expression of Trp53 208 0.78 175.35 16.65 76.72
27 INT97055 Positive_regulation of Gene_expression of Trp53 51 0.70 45.7 7.25 76.72
28 INT210805 Negative_regulation of IHH 2 0.42 0.74 0.08 72.00
29 INT228616 Negative_regulation of Gene_expression of EXT2 1 0.49 0.78 0 71.28
30 INT228613 Negative_regulation of Gene_expression of EXT1 1 0.42 1.08 0 71.28
31 INT324044 Negative_regulation of Lemd3 1 0.43 2.86 0 60.24
32 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38 51.68
33 INT92680 Gene_expression of Fgf2 59 0.77 28.11 8.12 50.00
34 INT80220 Positive_regulation of Bcl2 71 0.58 57.73 7.86 50.00
35 INT163756 Phosphorylation of Stat1 45 0.82 14.51 6.11 50.00
36 INT62268 Positive_regulation of Cdkn1a 33 0.67 14.12 3.26 50.00
37 INT72138 Gene_expression of Pthlh 18 0.75 17.68 1.49 50.00
38 INT140983 Gene_expression of Ihh 7 0.78 2.06 1.15 50.00
39 INT124850 Gene_expression of Tpt1 42 0.77 14.51 0.79 50.00
40 INT187087 Binding of Cd44 5 0.47 2.79 0.66 50.00
41 INT150949 Gene_expression of Fgfr1 6 0.63 5.71 0.57 50.00
42 INT235835 Negative_regulation of Gene_expression of Hspg2 3 0.15 1.26 0.52 50.00
43 INT117440 Positive_regulation of Cdkn1a 3 0.67 2.95 0.4 50.00
44 INT131018 Phosphorylation of Cdkn1a 3 0.61 2.06 0.4 50.00
45 INT166716 Negative_regulation of Ihh 3 0.43 0.67 0.33 50.00
46 INT189833 Negative_regulation of Phosphorylation of Stat1 4 0.51 1.1 0.3 50.00
47 INT301361 Phosphorylation of Cdkn1a 2 0.79 1.21 0.09 50.00
48 INT210587 Binding of Pthlh 1 0.18 1.17 0.03 50.00
49 INT301358 Negative_regulation of Ext1 2 0.42 1.09 0 50.00
50 INT301362 Negative_regulation of Positive_regulation of Cdkn1a 1 0.41 0.39 0 50.00
51 INT324042 Regulation of Gene_expression of Ext1 1 0.45 0.12 0 50.00
52 INT324043 Localization of Lemd3 1 0.75 0 0 50.00
53 INT172965 Negative_regulation of Positive_regulation of Cdkn1a 4 0.41 1.84 0 50.00
54 INT324052 Binding of Banf1 1 0.18 0.48 0 50.00
55 INT301359 Positive_regulation of Fgfr3 1 0.19 0.64 0 50.00
56 INT324048 Positive_regulation of Negative_regulation of Lemd3 1 0.50 0.2 0 50.00
57 INT301357 Negative_regulation of Positive_regulation of Fgfr3 1 0.16 0.35 0 50.00
58 INT301356 Binding of Ihh 1 0.08 0.06 0 50.00
59 INT160622 Gene_expression of Pth1r 7 0.77 6.37 2 48.88
60 INT23257 Regulation of CRP 127 0.62 100.05 21.87 29.88
61 INT15687 Regulation of ESR1 91 0.60 40.42 7.95 29.88
62 INT823 Negative_regulation of ESR1 144 0.58 63.72 22.52 26.64
63 INT443 Localization of POMC 1020 0.81 284.52 443.17 25.00
64 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
65 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
66 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
67 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 5.00
68 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 5.00
69 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 5.00
70 INT52732 Negative_regulation of CRP 169 0.59 138.47 40.33 5.00
71 INT106745 Localization of CRP 65 0.81 66.44 15.21 5.00
72 INT505 Positive_regulation of GPT 89 0.67 69.38 14.94 5.00
73 INT6478 Negative_regulation of Binding of TNF 36 0.58 30.42 13.31 5.00
74 INT79545 Positive_regulation of Gene_expression of ESR1 82 0.64 39.42 12.18 5.00
75 INT114295 Gene_expression of Gli2 10 0.54 7.58 2.95 5.00
76 INT197791 Regulation of Pth1r 2 0.27 1.31 1.99 5.00
77 INT90377 Gene_expression of HBA1 26 0.75 7.34 1.51 5.00
78 INT292298 Positive_regulation of GOT2 5 0.45 3.7 1.46 5.00
79 INT197789 Regulation of Gene_expression of Pth1r 2 0.23 1.68 1.38 5.00
80 INT67097 Gene_expression of MIB1 20 0.75 21.06 1.03 5.00
81 INT199345 Gene_expression of Lyve1 11 0.50 8.44 0.89 5.00
82 INT177347 Positive_regulation of Gene_expression of Gli2 3 0.25 2.61 0.69 5.00
83 INT153257 Regulation of Ptch1 6 0.36 5.92 0.67 5.00
84 INT44080 Positive_regulation of HBA1 7 0.25 2.23 0.6 5.00
85 INT275892 Positive_regulation of Gene_expression of HBA1 7 0.67 2.4 0.24 5.00
86 INT197792 Regulation of Pthlh 3 0.24 2.47 0.18 5.00
87 INT197790 Gene_expression of Tmem150c 1 0.01 1.06 0 5.00
88 INT298953 Positive_regulation of Gene_expression of Lyve1 1 0.03 0.77 0 5.00
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