D:Multiple Sulfatase Deficiency Disease

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pChart

Disease Term
Synonyms Mucosulfatidosis, Multiple Sulfatase Deficiencies, Multiple Sulfatase Deficiency, Multiple Sulphatase Deficiency Disease, Sulfatidosis Juvenile Austin Type
Documents 4
Hot Single Events 11
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Multiple Sulfatase Deficiency Disease. They are ordered first by their relevance to Multiple Sulfatase Deficiency Disease and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT254909 ARSH Regulation of Sumf1 1 0.00 0.9 0.04 98.06
2 INT254908 ARSH Regulation of Eef1a1 1 0.00 0.89 0.04 98.06
3 INT277890 Binding of Ids and Tas2r111-ps2 1 0.08 0.5 0.09 5.00
4 INT277889 Regulation of Binding of Ids and Tas2r111-ps2 1 0.09 0.5 0.09 5.00
5 INT310674 Positive_regulation of Binding of ARSB and ELF3 1 0.07 2.46 0.05 5.00
6 INT331227 Binding of Becn1 and Pink1 1 0.03 1.13 0.05 5.00
7 INT310675 Binding of ARSB and ELF3 1 0.06 2.4 0.05 5.00
8 INT277892 IDS Regulation of Ids 1 0.18 0.41 0 5.00
9 INT331234 Binding of Becn1 and Pik3c3 Positive_regulation of Pik3c3 1 0.00 0.47 0 5.00
10 INT331226 Binding of Becn1 and Pik3c3 1 0.02 0.47 0 5.00
11 INT331238 Binding of ULK1 and Pik3r1 1 0.09 0.48 0 5.00
12 INT331237 Negative_regulation of IMPA1 Negative_regulation of Itpr3 1 0.00 0.52 0 5.00
13 INT331232 Binding of Atg12 and Atg16l1 1 0.03 0.08 0 5.00
14 INT282995 Binding of Bcl2 and Becn1 21 0.03 9.8 0 5.00
15 INT331222 Tsc1 Negative_regulation of Mtor 1 0.00 0.68 0 5.00
16 INT331235 RASA1 Positive_regulation of Mtor 1 0.00 0.32 0 5.00
17 INT331225 Binding of Atg5 and Atg16l1 1 0.05 0.08 0 5.00
18 INT331231 Binding of Bcl2 and Mapk8 1 0.01 0.77 0 5.00
19 INT254906 Binding of Igfals and Chmp2b 1 0.02 0.85 0 5.00
20 INT331230 Binding of Mapk8 and Becn1 1 0.02 0.77 0 5.00
21 INT331228 Atg5 Positive_regulation of Atg12 1 0.06 0.08 0 5.00
22 INT331224 Binding of Akt1 and Tsc2 1 0.03 0.33 0 5.00
23 INT277891 Binding of TPBG and M6pr-ps 1 0.02 0.06 0 5.00
24 INT331223 Negative_regulation of Tsc1 Positive_regulation of Positive_regulation of Mtor 1 0.01 0.33 0 5.00
25 INT331229 Rasa1 Positive_regulation of Mtor 1 0.00 0.32 0 5.00
26 INT331233 Binding of Mtor and Rasa1 1 0.00 0.32 0 5.00
27 INT331236 Binding of RASA1 and Mtor 1 0.00 0.32 0 5.00
28 INT331221 Binding of Akt1 and Tsc1 1 0.03 0.33 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Multiple Sulfatase Deficiency Disease. They are ordered first by their pain relevance and then by number of times they were reported in Multiple Sulfatase Deficiency Disease. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT116728 Negative_regulation of ARSH 9 0.13 9.67 0.27 100.00
2 INT105991 Negative_regulation of IDS 12 0.38 6.31 1.04 100.00
3 INT157301 Negative_regulation of Map1lc3a 5 0.28 3.2 0.41 99.84
4 INT254878 Localization of Map1lc3a 5 0.57 3.32 0.2 99.84
5 INT254874 Negative_regulation of Localization of Map1lc3a 1 0.18 1.05 0 99.84
6 INT254887 Negative_regulation of Lamp1 2 0.20 3.17 0 99.48
7 INT254876 Negative_regulation of Localization of Lamp1 2 0.20 2.07 0 99.48
8 INT254882 Localization of Lamp1 3 0.43 2.05 0 99.48
9 INT157302 Positive_regulation of Map1lc3a 27 0.66 11.31 0.79 98.64
10 INT157305 Gene_expression of Map1lc3a 47 0.75 18.04 1.93 98.28
11 INT254890 Positive_regulation of Sumf1 1 0.23 0.92 0.03 91.84
12 INT310678 Protein_catabolism of ARSH 1 0.06 1.76 0.04 79.20
13 INT310683 Protein_catabolism of ARSB 1 0.73 1.85 0.04 79.20
14 INT310680 Gene_expression of ARSB 1 0.64 6.28 0.12 72.52
15 INT310681 Negative_regulation of ARSB 1 0.56 6.95 0.29 70.08
16 INT310679 Positive_regulation of ARSB 1 0.39 2.36 0.04 70.08
17 INT98239 Negative_regulation of Htt 13 0.43 7.84 0.6 51.64
18 INT254883 Negative_regulation of Positive_regulation of Htt 1 0.05 1.14 0 51.64
19 INT254875 Positive_regulation of Htt 10 0.47 4.07 0.96 49.24
20 INT254877 Positive_regulation of Gene_expression of Htt 15 0.64 6.29 0.28 43.32
21 INT87314 Gene_expression of Htt 112 0.78 55.82 3.03 42.28
22 INT310677 Localization of ARSB 1 0.71 5.72 0.14 39.84
23 INT157306 Positive_regulation of Positive_regulation of Map1lc3a 3 0.35 1.21 0.44 38.72
24 INT303326 Gene_expression of CHMP2B 25 0.75 10.08 0.76 34.76
25 INT303303 Positive_regulation of Gene_expression of CHMP2B 2 0.49 0.97 0 34.76
26 INT277884 Binding of Tas2r111-ps2 1 0.09 0.95 0.19 33.28
27 INT277878 Binding of Ids 4 0.34 0.8 0.24 29.44
28 INT193493 Negative_regulation of tor 3 0.25 1.77 0.18 25.32
29 INT85640 Gene_expression of Tg(CAG-EGFP)D4Nagy 1138 0.72 311.58 119.18 5.00
30 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34 5.00
31 INT106525 Phosphorylation of Akt1 436 0.82 183.81 47.82 5.00
32 INT17561 Localization of Car2 303 0.79 60.95 44.52 5.00
33 INT96913 Positive_regulation of Mapk8 179 0.69 130.44 32.2 5.00
34 INT145426 Positive_regulation of Ros1 185 0.56 106.76 27.21 5.00
35 INT112029 Positive_regulation of Pik3r1 90 0.67 38.76 20.95 5.00
36 INT109511 Gene_expression of Bax 133 0.78 113.22 14.36 5.00
37 INT109304 Positive_regulation of Phosphorylation of Akt1 113 0.69 40.92 13.49 5.00
38 INT96915 Phosphorylation of Mapk8 73 0.81 40.69 11.44 5.00
39 INT25170 Positive_regulation of Localization of Car2 78 0.67 15.25 11.24 5.00
40 INT1129 Binding of Car2 69 0.35 14.01 9.2 5.00
41 INT93359 Positive_regulation of Trp53 90 0.70 69.77 6.24 5.00
42 INT24080 Negative_regulation of Mtor 64 0.37 41.56 5.19 5.00
43 INT116744 Binding of Pik3r1 22 0.36 12.77 5.01 5.00
44 INT75136 Binding of Akt1 27 0.27 8.81 4.15 5.00
45 INT151171 Positive_regulation of Pten 20 0.55 13.3 3.54 5.00
46 INT151586 Positive_regulation of Prkag1 51 0.54 18.7 3.34 5.00
47 INT36039 Gene_expression of Itpr3 19 0.72 3.75 2.93 5.00
48 INT105993 Gene_expression of IDS 26 0.78 10.83 2.41 5.00
49 INT174156 Localization of Trp53 16 0.72 13.52 1.18 5.00
50 INT172855 Binding of Bcl2 37 0.32 23.41 1.09 5.00
51 INT151774 Positive_regulation of Mtor 38 0.45 20.15 1.01 5.00
52 INT200462 Binding of IDS 13 0.31 4.95 1 5.00
53 INT236094 Localization of Gdnf 4 0.70 2.51 0.68 5.00
54 INT47553 Gene_expression of ARSH 11 0.42 4.93 0.65 5.00
55 INT137221 Gene_expression of Sh2d1b2 6 0.47 1.99 0.6 5.00
56 INT137222 Positive_regulation of Sh2d1b2 5 0.30 1.26 0.6 5.00
57 INT282380 Binding of Atg16l1 4 0.38 2.06 0.58 5.00
58 INT86246 Binding of Bcl2l1 8 0.37 6.67 0.57 5.00
59 INT226176 Protein_catabolism of Hmbs 15 0.61 13.17 0.56 5.00
60 INT217723 Regulation of IDS 15 0.25 2.12 0.49 5.00
61 INT277886 Localization of Ids 3 0.73 1.09 0.48 5.00
62 INT243418 Binding of Htt 14 0.30 5.94 0.44 5.00
63 INT250447 Positive_regulation of Binding of Car2 3 0.11 0.36 0.39 5.00
64 INT236107 Binding of Pdpk1 2 0.26 1.38 0.39 5.00
65 INT135045 Gene_expression of Atxn3 34 0.78 11.59 0.36 5.00
66 INT151167 Phosphorylation of Pten 3 0.72 1.69 0.35 5.00
67 INT151166 Positive_regulation of Phosphorylation of Pten 2 0.40 1.54 0.35 5.00
68 INT179816 Positive_regulation of Pdpk1 4 0.31 0.36 0.35 5.00
69 INT254881 Negative_regulation of Atg7 9 0.34 5.69 0.32 5.00
70 INT254886 Positive_regulation of Fasn 2 0.06 0.94 0.31 5.00
71 INT22882 Negative_regulation of IMPA1 10 0.57 5.19 0.31 5.00
72 INT237038 Gene_expression of Becn1 18 0.36 13.68 0.31 5.00
73 INT277882 Gene_expression of Ids 5 0.71 1.6 0.26 5.00
74 INT296853 Positive_regulation of Atg7 4 0.37 1.45 0.18 5.00
75 INT204987 Binding of Pink1 3 0.37 4.72 0.17 5.00
76 INT165481 Negative_regulation of Gene_expression of Map1lc3a 7 0.45 2.55 0.14 5.00
77 INT271943 Phosphorylation of Tsc2 9 0.52 3.35 0.13 5.00
78 INT153233 Negative_regulation of Ids 5 0.40 2.1 0.12 5.00
79 INT243972 Binding of Ulk1 3 0.16 0.36 0.12 5.00
80 INT277879 Positive_regulation of Gene_expression of Ids 3 0.44 0.14 0.11 5.00
81 INT199082 Positive_regulation of Binding of Akt1 4 0.17 1.25 0.11 5.00
82 INT287203 Negative_regulation of Gene_expression of Htt 7 0.37 5.08 0.07 5.00
83 INT282981 Positive_regulation of Gene_expression of Becn1 8 0.13 6.2 0.06 5.00
84 INT254880 Negative_regulation of Impa1 2 0.05 1.58 0.05 5.00
85 INT282985 Negative_regulation of Becn1 11 0.20 7.72 0.04 5.00
86 INT331204 Negative_regulation of Binding of Htt 1 0.04 0.64 0.04 5.00
87 INT271916 Positive_regulation of Phosphorylation of Tsc2 4 0.32 0.52 0.04 5.00
88 INT310682 Regulation of ARSB 1 0.43 0.98 0.04 5.00
89 INT271914 Negative_regulation of Tsc1 5 0.38 3.08 0.04 5.00
90 INT282982 Binding of Map1lc3a 4 0.28 1.77 0.03 5.00
91 INT254873 Regulation of Map1lc3a 5 0.58 1.24 0.03 5.00
92 INT243236 Localization of Nefl 3 0.73 1.57 0 5.00
93 INT331186 Binding of Atg13 1 0.10 0.09 0 5.00
94 INT331196 Positive_regulation of Phosphorylation of Atg13 1 0.14 0.25 0 5.00
95 INT331187 Positive_regulation of Becn1 2 0.09 1.01 0 5.00
96 INT271921 Negative_regulation of Tsc2 2 0.26 1.19 0 5.00
97 INT282974 Binding of Becn1 24 0.07 7.43 0 5.00
98 INT331192 Negative_regulation of Atg13 1 0.12 0.1 0 5.00
99 INT331203 Positive_regulation of Binding of Pdpk1 1 0.15 0.17 0 5.00
100 INT277883 Regulation of Tas2r111-ps2 1 0.05 0.15 0 5.00
101 INT282990 Negative_regulation of Binding of Becn1 6 0.08 1.44 0 5.00
102 INT277881 Negative_regulation of Tas2r111-ps2 1 0.07 0.15 0 5.00
103 INT277888 Binding of TPBG 1 0.35 0.06 0 5.00
104 INT123521 Phosphorylation of Bcl2 8 0.81 5 0 5.00
105 INT331181 Positive_regulation of Sh3glb1 1 0.04 0.46 0 5.00
106 INT306660 Binding of Rb1cc1 2 0.08 0.24 0 5.00
107 INT306668 Negative_regulation of Phosphorylation of Ulk1 2 0.14 0.27 0 5.00
108 INT331185 Positive_regulation of Ambra1 1 0.10 0.46 0 5.00
109 INT271936 Phosphorylation of Tsc1 4 0.73 1.76 0 5.00
110 INT254885 Gene_expression of Chmp2b 1 0.24 0.84 0 5.00
111 INT282967 Negative_regulation of Gene_expression of Becn1 3 0.08 2.04 0 5.00
112 INT306671 Positive_regulation of Phosphorylation of Rb1cc1 2 0.10 0.3 0 5.00
113 INT306662 Phosphorylation of Rb1cc1 2 0.17 0.3 0 5.00
114 INT331191 Negative_regulation of Phosphorylation of Atg13 1 0.12 0.1 0 5.00
115 INT254872 Binding of Aadacl3 1 0.00 0.43 0 5.00
116 INT331194 Negative_regulation of Ulk1 1 0.14 0.1 0 5.00
117 INT331193 Negative_regulation of Gene_expression of Atxn3 1 0.17 0.73 0 5.00
118 INT306665 Positive_regulation of Phosphorylation of Ulk1 3 0.23 0.58 0 5.00
119 INT254888 Binding of Chmp2b 1 0.13 0.88 0 5.00
120 INT331199 Binding of Rraga 1 0.03 0.31 0 5.00
121 INT331182 Phosphorylation of Atg13 1 0.23 0.25 0 5.00
122 INT331200 Regulation of Atg4a 1 0.01 0.39 0 5.00
123 INT331188 Positive_regulation of Atg10 1 0.10 0.08 0 5.00
124 INT217457 Negative_regulation of Nup62 2 0.33 0.94 0 5.00
125 INT254879 Binding of Atg5 3 0.27 0.26 0 5.00
126 INT331195 Positive_regulation of Negative_regulation of Tsc1 1 0.18 0.15 0 5.00
127 INT306672 Phosphorylation of Ulk1 5 0.27 0.88 0 5.00
128 INT331183 Binding of Atg12 1 0.12 0.08 0 5.00
129 INT254884 Binding of Hdac6 1 0.23 0.43 0 5.00
130 INT331206 Positive_regulation of Uvrag 1 0.07 0.46 0 5.00
131 INT331198 Negative_regulation of Dctn1 1 0.01 0.58 0 5.00
132 INT306664 Positive_regulation of Ulk1 3 0.23 0.61 0 5.00
133 INT303277 Protein_catabolism of Map1lc3a 3 0.94 0.31 0 5.00
134 INT331190 Positive_regulation of Rap2b 1 0.21 0.39 0 5.00
135 INT331197 Negative_regulation of Atg4a 1 0.02 0.74 0 5.00
136 INT331205 Protein_catabolism of Gdnf 1 0.03 0.57 0 5.00
137 INT277880 Gene_expression of Tas2r111-ps2 1 0.13 1.22 0 5.00
138 INT277877 Binding of M6pr-ps 1 0.02 0.06 0 5.00
139 INT306658 Binding of Map1lc3b 2 0.13 0.2 0 5.00
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