D:Multiple Trauma

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Disease Term
Synonyms Injuries Multiple, Injury Multiple, Multiple Injuries, MULTIPLE INJURY, Multiple Traumas, Multiple Wound, Multiple Wounds, TRAUMA MULTIPLE, TRAUMAS MULTIPLE, Wound Multiple, Wounds Multiple
Documents 290
Hot Single Events 28
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Multiple Trauma. They are ordered first by their relevance to Multiple Trauma and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT345011 Binding of GSN and PTAFR 1 0.09 0.83 0.12 91.88
2 INT341480 Binding of SCN1A and SCN4A 1 0.36 1.29 0.98 70.40
3 INT341479 Binding of SCN2A and SCN4A 1 0.37 1.29 0.98 70.00
4 INT272024 Gene_expression of GOPC Positive_regulation of Localization of COL7A1 1 0.10 0.86 0.14 12.56
5 INT195668 Binding of F2 and THBD 7 0.08 5.67 0.98 5.00
6 INT273244 Binding of VCF and Del(7)Tyr<c-23DVT>-p 1 0.00 2.94 0.55 5.00
7 INT222284 Negative_regulation of Casp1 Negative_regulation of Il18 1 0.01 0.79 0.46 5.00
8 INT222283 Negative_regulation of Casp1 Negative_regulation of Il1a 1 0.00 0.78 0.46 5.00
9 INT244421 Binding of DST and Ctss 1 0.02 0.42 0.41 5.00
10 INT345006 CSF2 Regulation of GSN 1 0.16 0.82 0.39 5.00
11 INT345007 CSF2 Regulation of DBP 1 0.14 0.82 0.39 5.00
12 INT345012 GSN Regulation of CCBE1 1 0.00 0.82 0.36 5.00
13 INT345010 GSN Regulation of DBP 1 0.26 0.81 0.36 5.00
14 INT345009 DBP Regulation of CCBE1 1 0.00 0.81 0.36 5.00
15 INT303126 Nos2 Positive_regulation of Gene_expression of Il6 1 0.13 4.38 0.34 5.00
16 INT303127 Gpt Positive_regulation of Gene_expression of Il6 1 0.09 4.38 0.34 5.00
17 INT244422 Binding of DST and Fig4 1 0.01 0.42 0.29 5.00
18 INT345008 Binding of ACTN1 and CSF2 1 0.02 0.53 0.26 5.00
19 INT192109 PAH Positive_regulation of Binding of COL7A1 1 0.04 1.45 0.2 5.00
20 INT303122 Nos2 Positive_regulation of Gene_expression of Gpt 1 0.37 1.86 0.16 5.00
21 INT303121 Gpt Positive_regulation of Gene_expression of Gpt 1 0.25 1.86 0.16 5.00
22 INT303129 Nos2 Positive_regulation of Gene_expression of Gpt 1 0.17 1.86 0.16 5.00
23 INT292750 Akt1 Positive_regulation of Bcl2 1 0.01 1.67 0.15 5.00
24 INT292749 Akt1 Positive_regulation of Ctnnd2 1 0.09 1.73 0.15 5.00
25 INT292748 Akt1 Negative_regulation of Positive_regulation of Casp3 1 0.01 1.81 0.15 5.00
26 INT303128 Tnrc6a Regulation of Gene_expression of Nos2 1 0.00 0.57 0.14 5.00
27 INT303124 Binding of Fas and Tnfrsf10b 1 0.09 1.03 0.08 5.00
28 INT303123 Gpt Positive_regulation of Gene_expression of Mpo 1 0.22 0.99 0.08 5.00
29 INT303125 Nos2 Positive_regulation of Gene_expression of Mpo 1 0.34 0.99 0.08 5.00
30 INT298733 INS Regulation of ACSBG1 1 0.00 0.97 0.05 5.00
31 INT298734 USE1 Regulation of ACSBG1 1 0.00 0.97 0.05 5.00
32 INT222295 Binding of CPP and Cebpz 1 0.00 0.73 0.05 5.00
33 INT316101 Binding of HIST1H4PS1 and ANGPTL5 1 0.01 0.28 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Multiple Trauma. They are ordered first by their pain relevance and then by number of times they were reported in Multiple Trauma. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT131788 Positive_regulation of NPPB 87 0.67 86.1 8.81 99.62
2 INT145971 Localization of Nav1 20 0.81 10.3 18.11 99.08
3 INT266567 Regulation of Localization of Nav1 1 0.21 1.89 0.83 99.08
4 INT12598 Binding of DBP 20 0.48 13.11 3.62 97.72
5 INT170646 Negative_regulation of Fig4 213 0.37 81.29 46.92 97.72
6 INT5219 Negative_regulation of DBP 43 0.57 23.35 4.26 97.08
7 INT345019 Negative_regulation of Binding of DBP 1 0.36 0.75 0.1 97.08
8 INT61644 Gene_expression of Gc 16 0.70 11.35 1.95 95.88
9 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 95.64
10 INT97366 Regulation of Nav1 38 0.62 23.63 38.17 95.64
11 INT94199 Regulation of DRGX 9 0.07 8.31 10.39 94.60
12 INT23921 Negative_regulation of NPPB 13 0.58 16.19 0.9 94.44
13 INT189239 Binding of GSN 11 0.36 9.34 1.93 93.88
14 INT102076 Regulation of DST 15 0.22 10 3.5 92.92
15 INT244415 Regulation of Ctss 1 0.26 1.57 1.17 92.92
16 INT1416 Transcription of POMC 40 0.72 10.71 15.38 91.60
17 INT66191 Gene_expression of DBP 42 0.66 22.25 3.18 91.12
18 INT67101 Gene_expression of DST 47 0.54 25.92 9.59 91.08
19 INT62950 Gene_expression of NPPB 73 0.75 65.91 6.54 90.88
20 INT189230 Gene_expression of GSN 12 0.75 25.04 7.6 90.76
21 INT254400 Negative_regulation of GSN 22 0.57 18.15 5.89 90.76
22 INT13302 Binding of PTAFR 20 0.48 7.03 3.7 90.40
23 INT142690 Positive_regulation of Gene_expression of DRGX 10 0.23 8.54 5.69 88.88
24 INT55224 Gene_expression of DRGX 99 0.31 67.55 67.63 88.48
25 INT100965 Positive_regulation of Nav1 85 0.70 37.74 75.35 88.32
26 INT72923 Positive_regulation of MCRS1 72 0.50 99.19 30.36 87.96
27 INT97368 Negative_regulation of Nav1 62 0.59 41.56 60.27 82.48
28 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 81.96
29 INT11047 Positive_regulation of Positive_regulation of IL6 45 0.66 28.7 9.37 79.24
30 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 78.08
31 INT2909 Positive_regulation of Abat 334 0.70 62.1 256.43 76.08
32 INT84264 Regulation of NPPB 22 0.61 21.18 1.94 75.96
33 INT97646 Binding of Gc 6 0.36 3.56 1.32 71.92
34 INT103518 Negative_regulation of SCN2A 17 0.57 8.4 5.4 71.04
35 INT341484 Negative_regulation of SCN1A 1 0.53 1.27 0.94 71.04
36 INT186450 Negative_regulation of SFTPB 17 0.58 10.94 0.31 69.80
37 INT212050 Negative_regulation of Gene_expression of SFTPB 1 0.32 0.95 0 69.80
38 INT186461 Gene_expression of SFTPB 10 0.73 8.69 1.09 69.04
39 INT37758 Gene_expression of GC 10 0.75 7.09 1.75 68.24
40 INT711 Positive_regulation of PIK3C2A 83 0.70 76.87 13.18 68.04
41 INT89543 Gene_expression of NEFL 18 0.75 10.6 2.67 67.44
42 INT23598 Binding of SCN5A 32 0.40 16 5.35 65.96
43 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 65.80
44 INT44092 Binding of ACTN1 7 0.20 1.52 0.62 65.76
45 INT174663 Positive_regulation of KAT8 4 0.11 3.45 0.22 61.96
46 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 61.92
47 INT2792 Gene_expression of Mb 91 0.76 41.56 10.25 61.80
48 INT341481 Binding of SCN8A 1 0.28 1.47 1.23 60.84
49 INT12082 Localization of IL6 365 0.81 241.78 105.78 59.92
50 INT46692 Binding of SCN9A 4 0.36 2.55 2.13 58.44
51 INT10139 Positive_regulation of F13A1 64 0.56 44.75 9.69 54.04
52 INT3881 Positive_regulation of Protein_catabolism of F13A1 21 0.41 20 3.28 54.04
53 INT1888 Protein_catabolism of F13A1 97 0.99 63.48 14.82 53.64
54 INT46460 Gene_expression of NAV1 288 0.78 135.51 305.75 51.60
55 INT153194 Positive_regulation of Positive_regulation of Nav1 5 0.50 3.44 4.24 50.04
56 INT113490 Gene_expression of SCN9A 22 0.77 5.45 12.27 49.08
57 INT120752 Positive_regulation of Gene_expression of NPPB 17 0.67 16.4 2.21 45.36
58 INT117675 Transcription of Nav1 46 0.72 30.23 44.01 43.44
59 INT259760 Localization of Fbn2 5 0.05 5.55 2.85 35.92
60 INT35349 Gene_expression of CENPJ 52 0.57 25.36 2.54 32.00
61 INT242293 Positive_regulation of Positive_regulation of NPPB 5 0.56 2.92 0.33 28.64
62 INT133846 Binding of NPPB 14 0.42 11.52 0.98 25.12
63 INT298735 Negative_regulation of ACSBG1 1 0.01 0.65 0 24.44
64 INT23465 Gene_expression of S100b 31 0.76 15.09 6.2 24.40
65 INT184890 Regulation of MCRS1 35 0.22 44.35 13.78 21.76
66 INT181017 Gene_expression of Ctss 6 0.65 9.82 6.19 20.80
67 INT181040 Positive_regulation of Gene_expression of Ctss 2 0.45 1.51 0.75 20.80
68 INT97367 Gene_expression of Nav1 243 0.78 132.97 286.66 20.52
69 INT173751 Transcription of Fig4 31 0.46 8.28 3.7 19.48
70 INT11685 Regulation of CSF2 99 0.59 58.82 15.9 17.44
71 INT20676 Gene_expression of Ctse 16 0.77 10.59 4.68 16.16
72 INT79719 Negative_regulation of VAPA 6 0.43 2.94 0.21 15.76
73 INT2144 Localization of COL7A1 36 0.74 20.92 4.67 12.56
74 INT79726 Binding of Spef1 2 0.05 0.44 0 12.36
75 INT266561 Negative_regulation of Positive_regulation of Sorbs1 1 0.01 1.01 0.88 12.00
76 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 10.96
77 INT4605 Negative_regulation of Gene_expression of INS 220 0.58 139.66 10.75 10.96
78 INT43604 Gene_expression of Cfh 3 0.19 2.05 0.62 10.44
79 INT159472 Localization of NPPB 32 0.79 33.67 3.59 9.76
80 INT141642 Positive_regulation of Ctsa 5 0.49 2.87 1.27 7.60
81 INT74838 Positive_regulation of Sorbs1 18 0.34 6.93 12.63 7.44
82 INT49129 Positive_regulation of GFAP 35 0.69 28.78 10.38 7.28
83 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 6.48
84 INT266562 Gene_expression of Fbn2 1 0.05 0.93 0.84 5.04
85 INT266563 Positive_regulation of Gene_expression of Fbn2 1 0.04 0.93 0.84 5.04
86 INT443 Localization of POMC 1020 0.81 284.52 443.17 5.00
87 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 5.00
88 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
89 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 5.00
90 INT22548 Positive_regulation of Casp3 483 0.70 258.78 213.07 5.00
91 INT48955 Gene_expression of Nos2 753 0.78 403.87 208.08 5.00
92 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 5.00
93 INT66280 Gene_expression of Nos2 534 0.78 330.78 157.07 5.00
94 INT812 Localization of INS 1026 0.81 515.6 145.31 5.00
95 INT48895 Gene_expression of Il10 333 0.78 221.2 138.52 5.00
96 INT48953 Positive_regulation of Nos2 486 0.70 239.85 131.87 5.00
97 INT5842 Gene_expression of Gfap 372 0.78 153.71 127.71 5.00
98 INT65054 Positive_regulation of Nfkb1 285 0.70 149.33 126.73 5.00
99 INT6128 Positive_regulation of Localization of POMC 256 0.70 68.77 121.64 5.00
100 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 5.00
101 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 5.00
102 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 5.00
103 INT170025 Gene_expression of Fig4 588 0.67 183.27 113.32 5.00
104 INT27096 Positive_regulation of Nfkb1 325 0.70 195.11 109.06 5.00
105 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 5.00
106 INT77435 Positive_regulation of Nos2 343 0.70 208.49 91.43 5.00
107 INT10166 Localization of Tnf 237 0.81 153.95 88.64 5.00
108 INT54571 Positive_regulation of NFKB1 263 0.70 138.99 87.32 5.00
109 INT84546 Positive_regulation of Ppara 481 0.70 334.21 83.45 5.00
110 INT64636 Positive_regulation of Gene_expression of Nos2 242 0.70 147.52 79.53 5.00
111 INT12720 Positive_regulation of Il1 246 0.70 195.97 72.05 5.00
112 INT5969 Gene_expression of Il1a 221 0.75 96.31 71.38 5.00
113 INT171145 Positive_regulation of Fig4 274 0.59 93.55 69.81 5.00
114 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 5.00
115 INT24989 Positive_regulation of Cfp 125 0.61 29.55 64.9 5.00
116 INT11937 Localization of Il6 228 0.81 139.83 64.39 5.00
117 INT9657 Positive_regulation of Gene_expression of Il6 237 0.70 180.45 63.6 5.00
118 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 5.00
119 INT17564 Gene_expression of Gpt 322 0.75 208.51 60.36 5.00
120 INT546 Binding of ALB 311 0.48 85.98 60.14 5.00
121 INT55344 Gene_expression of Ros1 396 0.54 217.64 59.98 5.00
122 INT6623 Gene_expression of NA 231 0.78 45.78 59.36 5.00
123 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 5.00
124 INT48891 Positive_regulation of Il10 143 0.70 101.42 56.72 5.00
125 INT647 Gene_expression of SGCG 211 0.75 78.46 55.82 5.00
126 INT251 Regulation of INS 398 0.62 232.47 55.04 5.00
127 INT82650 Gene_expression of Bcl2 312 0.78 211.71 55.03 5.00
128 INT117713 Phosphorylation of Akt1 275 0.82 95.82 54.34 5.00
129 INT48952 Negative_regulation of Nos2 204 0.59 101.73 53.15 5.00
130 INT62543 Gene_expression of Icam1 231 0.78 187.58 52.71 5.00
131 INT12345 Gene_expression of Il2 142 0.78 59.17 51.21 5.00
132 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 5.00
133 INT2604 Positive_regulation of Got1 223 0.70 154.78 49.51 5.00
134 INT375 Positive_regulation of REN 293 0.70 152.46 47.55 5.00
135 INT49552 Negative_regulation of Positive_regulation of Casp3 76 0.55 36.04 44.78 5.00
136 INT25610 Positive_regulation of Gene_expression of Il1 136 0.67 104.43 43.86 5.00
137 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 5.00
138 INT50957 Negative_regulation of Il6 134 0.59 79.08 42.67 5.00
139 INT77434 Positive_regulation of Gene_expression of Nos2 151 0.69 96.76 38.94 5.00
140 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 5.00
141 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38 5.00
142 INT3253 Negative_regulation of Localization of INS 205 0.59 130.39 36.61 5.00
143 INT17736 Gene_expression of Cfp 111 0.65 40.68 36.61 5.00
144 INT9239 Regulation of Gene_expression of IL6 106 0.61 75.24 36.53 5.00
145 INT84260 Positive_regulation of Mapk8 124 0.69 72.84 35.98 5.00
146 INT18893 Positive_regulation of CPP 81 0.69 38.03 34.33 5.00
147 INT92837 Negative_regulation of Gene_expression of Nos2 116 0.59 59.67 31.82 5.00
148 INT11650 Negative_regulation of Gpt 122 0.59 69.15 30.36 5.00
149 INT72252 Gene_expression of Kcnma1 63 0.64 20.47 29.56 5.00
150 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 5.00
151 INT86437 Binding of IL6 154 0.48 121.22 29.3 5.00
152 INT15610 Localization of GOPC 223 0.65 68.26 28.7 5.00
153 INT11361 Gene_expression of SERPINE1 183 0.78 136.45 27.97 5.00
154 INT112707 Negative_regulation of Akt1 89 0.59 28.85 27.76 5.00
155 INT177581 Regulation of Fig4 113 0.41 39.26 27.75 5.00
156 INT115909 Positive_regulation of Gene_expression of Nav1 25 0.70 16.58 27.63 5.00
157 INT14690 Localization of CSF2 124 0.80 85.17 27.26 5.00
158 INT9647 Gene_expression of PROC 163 0.65 89.76 26.75 5.00
159 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7 5.00
160 INT5966 Localization of Il1a 50 0.78 22.91 26.54 5.00
161 INT76095 Positive_regulation of ISYNA1 117 0.55 79.73 25.86 5.00
162 INT93626 Gene_expression of Fasl 118 0.75 115.24 25.11 5.00
163 INT49141 Gene_expression of Selp 157 0.78 85.22 24.78 5.00
164 INT40776 Gene_expression of Akt1 99 0.77 34.91 24.39 5.00
165 INT64076 Positive_regulation of Kcnma1 47 0.40 11.52 24.19 5.00
166 INT15511 Gene_expression of Tnfrsf1a 84 0.76 63.3 24.03 5.00
167 INT58301 Positive_regulation of Mpo 87 0.70 80.19 23.99 5.00
168 INT9292 Positive_regulation of SGCG 93 0.67 35.13 23.48 5.00
169 INT1221 Regulation of SGCG 65 0.60 24.21 22.94 5.00
170 INT71875 Localization of Nfkb1 92 0.78 48.13 22.94 5.00
171 INT117674 Regulation of Gene_expression of Nav1 16 0.62 11.5 22.01 5.00
172 INT23257 Regulation of CRP 127 0.62 100.05 21.87 5.00
173 INT105021 Binding of GOPC 187 0.40 60.39 20.38 5.00
174 INT6993 Negative_regulation of Mpo 72 0.59 61.83 19.51 5.00
175 INT74286 Regulation of Il10 42 0.44 28.06 19.44 5.00
176 INT184895 Gene_expression of MCRS1 46 0.42 56.03 19.44 5.00
177 INT101188 Gene_expression of Rela 81 0.56 23.43 19.15 5.00
178 INT93734 Positive_regulation of Gene_expression of Bcl2 76 0.70 61.95 18.46 5.00
179 INT87861 Gene_expression of Il18 33 0.78 30.44 18.42 5.00
180 INT3952 Negative_regulation of ALB 116 0.59 72.18 18.35 5.00
181 INT11938 Positive_regulation of Localization of Il6 61 0.70 35.72 18.25 5.00
182 INT61519 Gene_expression of Mpo 112 0.78 89.29 18.22 5.00
183 INT86673 Positive_regulation of Bcl2 77 0.70 57.74 17.37 5.00
184 INT62546 Positive_regulation of Gene_expression of Icam1 60 0.70 59.52 16.9 5.00
185 INT170033 Positive_regulation of Gene_expression of Fig4 59 0.43 20.99 16.69 5.00
186 INT10187 Gene_expression of Il2ra 91 0.78 52.67 16.66 5.00
187 INT77620 Gene_expression of Fas 146 0.78 72.4 16.61 5.00
188 INT77433 Regulation of Gene_expression of Nos2 49 0.62 35.07 16.33 5.00
189 INT80972 Gene_expression of Tp53 104 0.78 102.74 16.02 5.00
190 INT14152 Gene_expression of Slc17a5 46 0.61 20.01 15.9 5.00
191 INT81627 Gene_expression of Fas 120 0.78 115.51 15.36 5.00
192 INT170335 Gene_expression of INCENP 176 0.54 91.62 15.31 5.00
193 INT49532 Regulation of Gene_expression of Il6 43 0.61 25.8 14.99 5.00
194 INT93482 Localization of Rela 56 0.78 24.52 14.82 5.00
195 INT11636 Positive_regulation of SERPINE1 85 0.69 68.73 14.8 5.00
196 INT20420 Gene_expression of MYC 99 0.75 49.32 14.36 5.00
197 INT109511 Gene_expression of Bax 133 0.78 113.22 14.36 5.00
198 INT10173 Binding of Tnf 45 0.48 35.6 14.32 5.00
199 INT22301 Positive_regulation of Gene_expression of CSF2 66 0.63 59.49 14.24 5.00
200 INT14572 Binding of INS 205 0.48 175.43 13.38 5.00
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