D:Mycosis Fungoides

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Disease Term
Synonyms Fungoides Granuloma, Mycosis Fungoides Lymphoma
Documents 71
Hot Single Events 61
Hot Interactions 3

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Mycosis Fungoides. They are ordered first by their relevance to Mycosis Fungoides and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT277692 Binding of Atp9a and Tnfrsf10b 1 0.00 1.47 0.1 99.64
2 INT350906 Twist1 Positive_regulation of Gene_expression of Cd4 1 0.10 1.49 0 98.84
3 INT350907 Twist1 Positive_regulation of Gene_expression of Cd7 1 0.05 1.49 0 98.84
4 INT277693 Stat6 Positive_regulation of Positive_regulation of Casp3 1 0.01 1.01 0 77.00
5 INT277694 Cdkn1a Positive_regulation of Positive_regulation of Casp3 1 0.00 1.01 0 77.00
6 INT277691 Cdkn1a Negative_regulation of Positive_regulation of Casp3 1 0.00 1.01 0 76.60
7 INT351011 Binding of HDAC9 and TSPYL2 1 0.04 0.63 0.08 64.52
8 INT350909 Binding of Pcsk4 and Twist1 1 0.02 1.91 0.08 50.00
9 INT350908 Binding of Bcl2 and Twist1 1 0.04 1.9 0.08 50.00
10 INT350905 Binding of Bcl2 and Pcsk4 1 0.03 0.96 0.04 50.00
11 INT101942 Binding of CD40 and CD40LG 16 0.23 15.24 4.01 5.00
12 INT351007 Binding of IL2 and IL2RA 1 0.33 1.33 0.26 5.00
13 INT193695 Il2 Positive_regulation of Ctla4 1 0.01 1.63 0.18 5.00
14 INT259023 CADPS Positive_regulation of Binding of SH2B2 1 0.06 2.05 0.14 5.00
15 INT193693 Binding of Myd88 and Pain1 1 0.14 0.82 0.13 5.00
16 INT193697 Apaf1 Positive_regulation of CASP9 1 0.02 1.84 0.12 5.00
17 INT193691 Positive_regulation of Positive_regulation of Bcr 1 0.01 0.07 0.08 5.00
18 INT193692 IgG2a Positive_regulation of Bcr 1 0.02 0.07 0.08 5.00
19 INT193694 IgG2a Positive_regulation of Tlr9 1 0.05 0.07 0.08 5.00
20 INT234381 Binding of CD40 and PPARA 1 0.19 1.39 0.07 5.00
21 INT351010 ISG20 Positive_regulation of Transcription of IL2 1 0.31 0.46 0.05 5.00
22 INT351009 IL2RG Positive_regulation of Transcription of IL2 1 0.27 0.44 0.05 5.00
23 INT351012 IL2RB Positive_regulation of Gene_expression of IL15 1 0.10 0.42 0.05 5.00
24 INT351008 IL2RB Positive_regulation of Gene_expression of IL2 1 0.18 0.42 0.05 5.00
25 INT234379 BAX Positive_regulation of CASP3 1 0.04 1.16 0.04 5.00
26 INT234382 Binding of TNF and TNFSF10 1 0.11 1.2 0.04 5.00
27 INT234380 Negative_regulation of Binding of CD40 and CD40LG 1 0.16 1.4 0.04 5.00
28 INT234383 Positive_regulation of Binding of TNF and TNFSF10 1 0.15 1.2 0.04 5.00
29 INT193696 Binding of CD8A and Trav6-3 1 0.00 0.85 0 5.00
30 INT297614 ZNF275 Positive_regulation of Gene_expression of TSC1 1 0.00 1.56 0 5.00
31 INT351013 PROK1 Regulation of ISG20 1 0.01 0.76 0 5.00
32 INT297613 Negative_regulation of ZNF275 Positive_regulation of Gene_expression of TSC1 1 0.00 1.66 0 5.00
33 INT234378 MAPK7 Positive_regulation of PPARA 1 0.21 0.05 0 5.00
34 INT297615 Binding of TSC1 and HDAC9 1 0.01 0.4 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Mycosis Fungoides. They are ordered first by their pain relevance and then by number of times they were reported in Mycosis Fungoides. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT59962 Gene_expression of Pcsk4 2 0.49 3 0 100.00
2 INT234409 Gene_expression of TSPYL2 2 0.21 5.16 0.03 100.00
3 INT79395 Gene_expression of Twist1 193 0.77 100.06 26.34 100.00
4 INT80222 Negative_regulation of Bcl2 82 0.58 69.16 13.18 100.00
5 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38 99.84
6 INT81640 Positive_regulation of Gene_expression of Bcl2 106 0.69 84.58 11.63 99.84
7 INT261118 Binding of Tnfrsf10b 3 0.07 4.03 0.1 99.38
8 INT114874 Gene_expression of Stat3 78 0.76 53.99 9.49 98.68
9 INT22900 Positive_regulation of Cd4 126 0.67 82.77 16.43 98.42
10 INT18909 Positive_regulation of Cd8a 92 0.60 56.55 7.35 98.42
11 INT350901 Positive_regulation of Pcsk4 1 0.08 1.59 0 98.08
12 INT49214 Gene_expression of Cd4 269 0.78 154.22 34.05 97.76
13 INT350903 Gene_expression of Cd7 1 0.23 1.48 0 97.76
14 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 97.20
15 INT3988 Positive_regulation of Gene_expression of IGHE 98 0.68 91.46 9.61 95.12
16 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 95.12
17 INT15804 Gene_expression of ISG20 83 0.75 44.33 10.58 94.28
18 INT279323 Binding of Il2rb 1 0.09 1.86 0 94.08
19 INT5788 Gene_expression of IL2RA 60 0.75 40.67 9.98 93.76
20 INT25163 Positive_regulation of Gene_expression of IL2RA 8 0.45 5.37 1.71 93.76
21 INT20381 Localization of Il2 71 0.77 34.23 13.03 93.28
22 INT19509 Localization of Ifng 55 0.78 28.25 18.67 93.28
23 INT90792 Localization of Il10 144 0.80 87.88 30.03 93.28
24 INT20379 Localization of Il4 85 0.73 51.22 20.55 93.28
25 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 93.28
26 INT234419 Phosphorylation of TSPYL2 1 0.16 2.05 0.06 93.12
27 INT2241 Negative_regulation of CEL 56 0.58 29.32 8.83 92.00
28 INT35086 Positive_regulation of Gene_expression of Ifng 40 0.69 22.55 18.35 91.72
29 INT7532 Negative_regulation of Gene_expression of Ifng 33 0.59 18.56 13.14 91.40
30 INT88051 Regulation of Gene_expression of IL2RG 2 0.24 1.57 0.65 91.36
31 INT27628 Gene_expression of IL2RG 28 0.75 20.95 6.16 91.36
32 INT82379 Negative_regulation of Cd7 1 0.16 1.18 0 91.04
33 INT52968 Regulation of Gene_expression of IL2RB 2 0.16 1.57 0 90.64
34 INT11049 Gene_expression of IL2RB 8 0.60 3.73 0.76 90.64
35 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18 90.32
36 INT351020 Positive_regulation of P4HB 1 0.09 0.69 0 90.28
37 INT50051 Regulation of Pcsk4 2 0.24 1.07 0.13 90.16
38 INT21532 Negative_regulation of Gene_expression of Il2 47 0.59 20.43 16.96 90.08
39 INT141275 Negative_regulation of Gene_expression of Hand1 18 0.34 15.83 5.05 90.08
40 INT11807 Gene_expression of Il2 266 0.78 112 64.97 89.68
41 INT7534 Gene_expression of Ifng 193 0.78 111.02 68.6 89.68
42 INT20375 Gene_expression of Hand1 213 0.60 148.51 54.53 89.68
43 INT81627 Gene_expression of Fas 120 0.78 115.51 15.36 89.12
44 INT50954 Regulation of IL2RA 5 0.25 3.09 0.77 89.12
45 INT62268 Positive_regulation of Cdkn1a 33 0.67 14.12 3.26 89.04
46 INT61087 Positive_regulation of Gene_expression of Il2ra 12 0.35 9.1 3.25 89.00
47 INT6852 Localization of TNF 883 0.81 705.95 270.84 89.00
48 INT5660 Binding of Oprd1 477 0.48 71.86 342.06 88.80
49 INT10187 Gene_expression of Il2ra 91 0.78 52.67 16.66 88.64
50 INT11050 Regulation of Gene_expression of IL2RA 3 0.41 1.4 0.15 86.96
51 INT132575 Binding of NR1H4 57 0.20 22.06 2.82 86.08
52 INT5979 Gene_expression of Oprd1 428 0.78 75.64 320.32 85.36
53 INT10668 Positive_regulation of Gene_expression of Oprd1 61 0.69 15.21 52.12 85.36
54 INT64234 Regulation of Bcl2 41 0.54 31.88 3.16 85.04
55 INT135527 Negative_regulation of Gene_expression of Cd4 17 0.43 6.72 1.09 84.76
56 INT350902 Negative_regulation of Cd7 1 0.15 1.87 0 83.88
57 INT89966 Negative_regulation of Fas 26 0.58 24.83 3.5 83.52
58 INT10709 Negative_regulation of CD4 106 0.59 95.6 14.89 82.60
59 INT86024 Gene_expression of PPARA 736 0.78 497.93 91.14 82.00
60 INT75501 Gene_expression of CCND1 90 0.76 60.86 5.93 81.48
61 INT75498 Positive_regulation of Gene_expression of CCND1 21 0.68 19.4 0.51 81.48
62 INT4465 Gene_expression of CEL 116 0.77 98.35 23.58 79.96
63 INT277670 Negative_regulation of Gene_expression of Stat6 1 0.14 2.12 0 78.48
64 INT228246 Negative_regulation of Gene_expression of Stat3 10 0.58 8.11 0.64 78.48
65 INT176606 Gene_expression of Stat6 9 0.65 6.87 0.77 77.92
66 INT277672 Localization of Cdkn1a 1 0.07 0.95 0 76.60
67 INT277673 Positive_regulation of Localization of Cdkn1a 1 0.05 1.01 0 76.60
68 INT125066 Negative_regulation of HDAC4 56 0.49 41.55 5.42 76.44
69 INT174516 Regulation of Gene_expression of ISG20 6 0.27 4.2 0.85 76.32
70 INT133647 Negative_regulation of HDAC9 149 0.57 106.84 17.9 75.92
71 INT243603 Localization of Stat6 6 0.68 2.96 0.4 75.92
72 INT277668 Positive_regulation of Localization of Stat6 1 0.14 2 0 75.92
73 INT97692 Positive_regulation of HDAC9 17 0.45 14.88 5.11 75.92
74 INT65600 Positive_regulation of Casp3 376 0.70 198.44 128.03 74.32
75 INT11747 Positive_regulation of IL2RA 22 0.67 16.55 6.95 74.16
76 INT22067 Positive_regulation of IL2RB 11 0.70 5.74 1.23 74.16
77 INT83236 Localization of PGR 14 0.73 8.26 2.23 74.08
78 INT62269 Gene_expression of Cdkn1a 60 0.73 35.78 9.84 74.00
79 INT62270 Positive_regulation of Gene_expression of Cdkn1a 30 0.47 18.73 5.69 74.00
80 INT275245 Positive_regulation of HIST2H2BE 2 0.15 1.94 0 73.60
81 INT297621 Positive_regulation of RLN3 1 0.05 2.79 0 73.60
82 INT3400 Positive_regulation of pr 57 0.68 36.9 16.24 72.88
83 INT100139 Positive_regulation of Gene_expression of PPARA 160 0.63 97.78 14.53 69.12
84 INT44122 Positive_regulation of AMPD1 4 0.44 1.88 0.92 66.88
85 INT1189 Gene_expression of AMPD1 7 0.59 4.1 0.9 66.20
86 INT119483 Negative_regulation of Gene_expression of AMPD1 2 0.04 1.95 0.5 66.20
87 INT81777 Negative_regulation of Gene_expression of IK 22 0.08 11.55 8.09 64.52
88 INT90875 Negative_regulation of CCND1 31 0.42 26.22 2.66 63.52
89 INT56072 Negative_regulation of NFKB1 94 0.59 53.16 28.19 63.20
90 INT52264 Gene_expression of IK 180 0.77 90.87 51.87 62.32
91 INT72651 Gene_expression of TH1L 114 0.75 80.15 35.15 61.88
92 INT174515 Negative_regulation of CD7 2 0.14 2.15 0.39 57.16
93 INT59964 Localization of Pcsk4 3 0.59 2.25 0.23 56.48
94 INT10873 Localization of Twist1 21 0.74 10.43 1.37 56.28
95 INT36100 Positive_regulation of Il2rb 7 0.49 4.18 2.32 56.08
96 INT350904 Localization of TSPYL2 1 0.03 1.04 0.04 55.36
97 INT16322 Gene_expression of Il2rb 19 0.51 15.88 12.18 53.52
98 INT43820 Positive_regulation of Twist1 75 0.59 42.15 8.47 50.00
99 INT172855 Binding of Bcl2 37 0.32 23.41 1.09 50.00
100 INT174753 Gene_expression of Apoa2 15 0.75 13.82 0.41 50.00
101 INT350900 Protein_catabolism of Twist1 1 0.22 0.78 0.05 50.00
102 INT350899 Positive_regulation of Cd7 1 0.14 0.78 0 50.00
103 INT173159 Localization of PPARA 96 0.74 64.55 10.26 49.36
104 INT65959 Positive_regulation of Gene_expression of BCL2 75 0.70 77.3 8.27 46.00
105 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73 45.60
106 INT19775 Localization of Il1 183 0.78 145.5 50.91 41.52
107 INT157357 Binding of IL2RA 6 0.44 5.18 1.63 35.64
108 INT214706 Gene_expression of Bok 3 0.09 7.22 0.11 29.44
109 INT193609 Protein_catabolism of HBEGF 4 0.30 2.77 0.3 27.76
110 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 27.12
111 INT98130 Positive_regulation of CASP8 79 0.67 65.29 10.08 26.32
112 INT95120 Positive_regulation of CASP9 76 0.67 67.55 5.33 26.32
113 INT122487 Positive_regulation of Positive_regulation of CASP9 16 0.67 17.88 1.79 26.32
114 INT135546 Positive_regulation of Positive_regulation of CASP8 13 0.31 10.97 0.28 26.32
115 INT136991 Localization of HBEGF 5 0.59 3.62 1.28 23.32
116 INT99510 Regulation of Gene_expression of CFLAR 2 0.08 2.8 0.68 20.80
117 INT234405 Regulation of Negative_regulation of CASP8 1 0.09 3.05 0 20.80
118 INT234423 Regulation of Gene_expression of CASP8 2 0.07 3.03 0 20.80
119 INT99509 Gene_expression of CFLAR 25 0.75 22.59 3.78 20.28
120 INT15543 Gene_expression of CASP8 32 0.75 25.6 2.61 20.28
121 INT234420 Regulation of Negative_regulation of CFLAR 2 0.13 2.77 0.03 20.28
122 INT234430 Negative_regulation of Gene_expression of CASP8 4 0.06 3.79 0 20.28
123 INT351019 Negative_regulation of Binding of EEF2 1 0.03 0.53 0.03 19.76
124 INT15542 Negative_regulation of CASP8 20 0.41 17.3 5.63 19.32
125 INT151983 Negative_regulation of CFLAR 13 0.57 13.51 2.05 18.92
126 INT351015 Binding of EEF2 1 0.03 0.47 0.03 18.36
127 INT41721 Negative_regulation of MTOR 40 0.58 32.49 2.83 17.44
128 INT53196 Binding of Cd4 44 0.47 27.28 5.85 17.00
129 INT22383 Binding of IL2 59 0.48 39.06 8.56 15.92
130 INT114379 Negative_regulation of Gene_expression of CFLAR 7 0.57 7.31 0.97 14.20
131 INT10019 Binding of CD8A 57 0.36 31.49 10.08 13.00
132 INT144390 Positive_regulation of Negative_regulation of CYP2C9 4 0.49 2.03 0.72 11.48
133 INT277669 Positive_regulation of Negative_regulation of Cyp3a11 1 0.09 1.46 0.03 11.48
134 INT5058 Positive_regulation of IFNA1 356 0.70 245.75 60.52 11.44
135 INT100938 Positive_regulation of Il13 47 0.69 42.11 14.36 11.04
136 INT59929 Negative_regulation of CYP2C9 60 0.59 16.33 15.39 10.92
137 INT76024 Negative_regulation of Cyp3a11 7 0.53 2.96 3.16 10.92
138 INT63975 Positive_regulation of Il10 175 0.68 134.13 54.69 10.56
139 INT97439 Positive_regulation of Il5 46 0.60 25.6 9.47 10.00
140 INT13186 Positive_regulation of Il4 113 0.68 71.22 31.4 9.52
141 INT11803 Positive_regulation of Il2 62 0.70 31.44 18.93 9.04
142 INT97108 Phosphorylation of IL2 5 0.73 2.47 1.7 6.16
143 INT351018 Phosphorylation of IL2RA 1 0.79 0.64 0.05 6.16
144 INT351017 Binding of IL2RG 1 0.17 0.44 0.16 5.92
145 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
146 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
147 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
148 INT60694 Gene_expression of Il10 567 0.78 369.48 143.69 5.00
149 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 5.00
150 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51 5.00
151 INT20374 Gene_expression of Il4 515 0.76 306.15 114.12 5.00
152 INT12082 Localization of IL6 365 0.81 241.78 105.78 5.00
153 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 5.00
154 INT77435 Positive_regulation of Nos2 343 0.70 208.49 91.43 5.00
155 INT67614 Positive_regulation of PPARA 438 0.68 293.28 63.61 5.00
156 INT73048 Gene_expression of MMP9 268 0.77 159.75 57.81 5.00
157 INT71786 Phosphorylation of MAPK1 256 0.82 110.09 46.17 5.00
158 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 5.00
159 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 5.00
160 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 5.00
161 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 5.00
162 INT11560 Positive_regulation of CASP3 236 0.70 184.33 39.38 5.00
163 INT103094 Binding of PPARA 308 0.47 177.26 34.75 5.00
164 INT6105 Positive_regulation of IL2 133 0.69 82.76 34.67 5.00
165 INT74563 Positive_regulation of Gene_expression of ROS1 258 0.61 168.18 34.08 5.00
166 INT84825 Gene_expression of CD36 121 0.78 43.73 33.23 5.00
167 INT10763 Localization of IL2 157 0.80 81.11 33.21 5.00
168 INT5117 Negative_regulation of Gene_expression of IL2 118 0.59 52.33 29.96 5.00
169 INT50230 Positive_regulation of Localization of IL6 105 0.70 69.21 29.52 5.00
170 INT83708 Negative_regulation of MAPK1 156 0.57 84.93 27.85 5.00
171 INT21900 Gene_expression of Mthfd1 150 0.75 69.47 27.03 5.00
172 INT17331 Positive_regulation of JUN 132 0.69 60.4 27.03 5.00
173 INT83797 Gene_expression of Bcl2l1 124 0.77 94.55 22.39 5.00
174 INT84732 Positive_regulation of Hand2 81 0.69 62.07 22 5.00
175 INT101517 Negative_regulation of PPARA 168 0.57 112.24 21.41 5.00
176 INT17848 Binding of PTGS2 70 0.46 32.1 20.6 5.00
177 INT91462 Positive_regulation of Phosphorylation of MAPK1 99 0.67 40.28 18.99 5.00
178 INT78024 Gene_expression of ACLY 73 0.75 59.15 18.54 5.00
179 INT18010 Positive_regulation of CD40LG 122 0.70 100.8 18.46 5.00
180 INT4420 Positive_regulation of GOT1 103 0.64 88.4 18.38 5.00
181 INT28215 Gene_expression of CDKN1A 196 0.76 113.9 18.3 5.00
182 INT19929 Negative_regulation of Positive_regulation of TNF 52 0.59 38.16 16.51 5.00
183 INT108588 Gene_expression of CASP3 126 0.78 84.49 16.2 5.00
184 INT9220 Gene_expression of Ighg1 125 0.77 85.74 15.92 5.00
185 INT75502 Positive_regulation of CDKN1A 123 0.68 70.75 14.74 5.00
186 INT60197 Gene_expression of JUN 90 0.78 42.32 14.61 5.00
187 INT103096 Regulation of PPARA 113 0.60 62.47 14.57 5.00
188 INT20420 Gene_expression of MYC 99 0.75 49.32 14.36 5.00
189 INT172171 Gene_expression of IL15 47 0.37 46.23 13.41 5.00
190 INT99780 Positive_regulation of Cxcl10 43 0.69 39.67 13.27 5.00
191 INT81629 Positive_regulation of Fas 58 0.70 59.63 12.94 5.00
192 INT51014 Transcription of IL2 42 0.71 21.56 12.7 5.00
193 INT31990 Positive_regulation of SOD1 124 0.69 67.79 12.52 5.00
194 INT69436 Negative_regulation of Gene_expression of ROS1 81 0.38 46.58 12.22 5.00
195 INT112003 Localization of ROS1 94 0.73 66.32 12.16 5.00
196 INT36287 Binding of CD4 96 0.47 58.93 11.88 5.00
197 INT58449 Binding of Mthfd1 47 0.47 22.02 10.29 5.00
198 INT122584 Negative_regulation of Gene_expression of PPARA 56 0.58 37.61 9.76 5.00
199 INT57162 Positive_regulation of Gene_expression of CDKN1A 64 0.68 35.3 9.69 5.00
200 INT3846 Positive_regulation of GSR 60 0.50 35.16 9.37 5.00
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