D:Myocarditis

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Disease Term
Synonyms Carditis, Myocardial Inflammation, Myocarditides
Documents 102
Hot Single Events 74
Hot Interactions 5

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Myocarditis. They are ordered first by their relevance to Myocarditis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT278292 Binding of CRP and ESR1 6 0.09 10.92 0.96 99.62
2 INT222691 Negative_regulation of Binding of FLNA and TNF 1 0.14 1.92 0.54 98.98
3 INT222692 Binding of FLNA and TNF 1 0.12 1.92 0.53 98.98
4 INT222690 TNF Positive_regulation of Gene_expression of NPEPPS 1 0.01 1.03 0.3 94.36
5 INT285344 Il10 Negative_regulation of Gene_expression of Tnf 1 0.15 1.91 0.49 93.84
6 INT332018 Binding of C1qa and Gopc 1 0.23 0.87 0.21 78.24
7 INT319753 Mpo Positive_regulation of Timp1 1 0.14 2.13 0.29 51.72
8 INT332017 Binding of Ighm and Mbl1 1 0.11 0.26 0.06 48.48
9 INT332013 Hc Regulation of Binding of C3ar1 1 0.12 1.11 0.21 48.40
10 INT332016 C3ar1 Regulation of Binding of Hc 1 0.12 1.11 0.21 48.40
11 INT332019 Binding of C3ar1 and Cfb 1 0.03 0.29 0.09 28.00
12 INT332014 Binding of Cfi and Cfb 1 0.00 0.29 0.09 26.68
13 INT179502 Binding of Cd14 and Tlr4 29 0.39 13.77 5.73 5.00
14 INT102130 Il6 Positive_regulation of Gene_expression of Crp 4 0.05 7.39 1.91 5.00
15 INT254205 Binding of Myd88 and Tlr4 12 0.19 3.17 1.54 5.00
16 INT151849 IL10 Negative_regulation of Gene_expression of IL8 4 0.14 3.26 1.54 5.00
17 INT276964 Binding of Tlr1 and Tlr2 11 0.24 4.22 0.89 5.00
18 INT187290 Binding of HEY1 and Gtf3a 1 0.00 6.18 0.83 5.00
19 INT288201 Mapk14 Positive_regulation of Cish 1 0.03 0.06 0.82 5.00
20 INT288202 Negative_regulation of Cd14 Positive_regulation of Positive_regulation of Mapk14 1 0.09 1.08 0.64 5.00
21 INT352972 IL4 Negative_regulation of Gene_expression of IL8 1 0.07 1.01 0.43 5.00
22 INT352986 IL10 Negative_regulation of Gene_expression of Il6 1 0.01 1 0.43 5.00
23 INT352985 IL4 Negative_regulation of Gene_expression of Il6 1 0.01 1 0.43 5.00
24 INT242992 Binding of Agt and Ppara 1 0.20 1.44 0.42 5.00
25 INT352970 IL4 Negative_regulation of Positive_regulation of TH1L 1 0.01 0.91 0.4 5.00
26 INT288208 Binding of Mapk14 and Positive_regulation of Akt1 1 0.01 0.42 0.35 5.00
27 INT288200 Tlr2 Positive_regulation of Pik3r1 1 0.05 0.24 0.33 5.00
28 INT242995 Agt Positive_regulation of Spp1 1 0.36 1.82 0.33 5.00
29 INT288198 Binding of Tlr4 and Mapk14 1 0.01 0.63 0.31 5.00
30 INT288203 Binding of Cd14 and Mapk14 1 0.08 0.63 0.31 5.00
31 INT288205 Binding of Cd14 and Myd88 1 0.10 0.57 0.28 5.00
32 INT242991 Agt Positive_regulation of Gene_expression of Spp1 1 0.21 0.66 0.26 5.00
33 INT285341 Mtx1 Regulation of Gene_expression of Tnf 1 0.03 0.78 0.22 5.00
34 INT285340 Mtx1 Regulation of Tnf 1 0.03 0.78 0.22 5.00
35 INT285342 Mtx1 Regulation of Il10 1 0.03 0.78 0.22 5.00
36 INT285343 Mtx1 Regulation of Il6 1 0.04 0.78 0.22 5.00
37 INT329323 ecs Positive_regulation of Gene_expression of Il6 1 0.00 0.52 0.21 5.00
38 INT242996 Adipoq Negative_regulation of Transcription of Cd68 1 0.22 0.6 0.21 5.00
39 INT242994 Adipoq Negative_regulation of Spp1 1 0.19 0.59 0.21 5.00
40 INT242993 Positive_regulation of Ppara Positive_regulation of Gene_expression of Spp1 1 0.24 0.66 0.18 5.00
41 INT329324 KNG1 Positive_regulation of Localization of ecs 1 0.00 1.16 0.17 5.00
42 INT329317 ACE Regulation of Positive_regulation of KNG1 1 0.02 1.05 0.12 5.00
43 INT329325 ACE Regulation of Negative_regulation of Agtr2 1 0.01 0.93 0.12 5.00
44 INT288210 Regulation of Tlr2 Positive_regulation of Akt1 1 0.03 0.09 0.08 5.00
45 INT288206 Tlr2 Positive_regulation of Akt1 1 0.04 0.09 0.08 5.00
46 INT288204 Akt1 Regulation of Mapk14 1 0.01 0.09 0.07 5.00
47 INT296893 Nps Negative_regulation of Gene_expression of REN 1 0.00 1.05 0.04 5.00
48 INT288199 Binding of Ptprc and Trav6-3 1 0.00 0.05 0.03 5.00
49 INT277490 Binding of F2 and Thbs1 1 0.09 0 0 5.00
50 INT277489 Binding of Thbs1 and Gopc 1 0.14 0 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Myocarditis. They are ordered first by their pain relevance and then by number of times they were reported in Myocarditis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT67060 Negative_regulation of Transcription of TNF 17 0.59 12.94 5.88 99.90
2 INT285338 Negative_regulation of Transcription of Il2 1 0.08 1.97 0.48 99.90
3 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 99.72
4 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 99.72
5 INT100861 Binding of CRP 179 0.48 175.2 26.45 99.62
6 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 99.56
7 INT48891 Positive_regulation of Il10 143 0.70 101.42 56.72 99.36
8 INT170381 Transcription of Gopc 59 0.60 15.96 6.82 99.36
9 INT13354 Transcription of TNF 108 0.72 85.81 42.32 99.32
10 INT85869 Transcription of Il2 5 0.23 2.49 0.95 99.32
11 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 99.22
12 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 99.06
13 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 99.02
14 INT118381 Gene_expression of Il17a 405 0.76 306.97 112.06 99.02
15 INT160564 Gene_expression of Il22 64 0.55 59.29 20.9 99.02
16 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 99.02
17 INT150022 Positive_regulation of Il17a 69 0.64 70.04 21.87 99.02
18 INT296054 Positive_regulation of Il22 13 0.33 17.97 4.06 99.02
19 INT18010 Positive_regulation of CD40LG 122 0.70 100.8 18.46 99.00
20 INT50039 Positive_regulation of Il4 48 0.55 34.8 23.34 98.96
21 INT103757 Negative_regulation of Il12a 37 0.55 21.62 16.38 98.32
22 INT12095 Negative_regulation of Edn1 26 0.59 12.01 8.79 98.20
23 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 98.16
24 INT47500 Gene_expression of MIS18A 1 0.65 1.74 0.22 97.76
25 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18 97.52
26 INT22098 Positive_regulation of Il2 27 0.69 14.77 14.1 97.36
27 INT171071 Negative_regulation of Hey2 1 0.03 1.31 0.48 97.08
28 INT10360 Positive_regulation of Ifng 33 0.68 21.73 15.19 97.00
29 INT9552 Positive_regulation of TNNI3 209 0.70 128.67 19.15 96.16
30 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 96.08
31 INT316215 Negative_regulation of Zbtb16 1 0.00 2.84 0 95.84
32 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 95.56
33 INT170051 Positive_regulation of Gene_expression of Gopc 150 0.43 56.75 16.93 95.52
34 INT332006 Positive_regulation of Gene_expression of Erlec1 1 0.04 1.11 0.25 95.52
35 INT6852 Localization of TNF 883 0.81 705.95 270.84 95.32
36 INT177759 Negative_regulation of IFN1@ 51 0.57 31.81 7.76 94.96
37 INT170332 Gene_expression of IFN1@ 477 0.75 275.21 69.65 94.12
38 INT60691 Gene_expression of Il12a 331 0.78 208.03 75.96 94.12
39 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 94.08
40 INT123627 Positive_regulation of Tnni1 2 0.38 1.77 0.56 93.28
41 INT332004 Positive_regulation of Gene_expression of Tnni1 1 0.03 1.07 0.18 93.28
42 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 92.92
43 INT82354 Positive_regulation of PECAM1 25 0.34 22.93 4.69 92.92
44 INT123626 Gene_expression of Tnni1 3 0.43 1.88 0.87 92.64
45 INT49995 Positive_regulation of Gene_expression of Tnf 187 0.70 125.07 70.54 92.52
46 INT135411 Gene_expression of Il23a 76 0.72 72.87 26.15 92.48
47 INT161515 Positive_regulation of Gene_expression of Il17a 50 0.64 41.52 13.82 92.36
48 INT1162 Gene_expression of Erlec1 4 0.06 1.25 1.05 92.36
49 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68 92.08
50 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 92.08
51 INT13353 Positive_regulation of Tnf 332 0.70 248.75 148.1 90.84
52 INT11313 Positive_regulation of Il6 526 0.70 331.27 201.59 90.84
53 INT15796 Regulation of IL2 66 0.61 25.43 20.62 90.24
54 INT5333 Gene_expression of NPEPPS 45 0.65 26.34 15.25 89.92
55 INT79061 Positive_regulation of NOS2 92 0.65 58.89 23.96 89.76
56 INT20374 Gene_expression of Il4 515 0.76 306.15 114.12 89.24
57 INT1878 Binding of HLA-B 440 0.48 321.16 127.36 89.20
58 INT14701 Negative_regulation of IFNA1 118 0.54 84.19 20.08 89.12
59 INT69304 Negative_regulation of Il10 47 0.59 36.88 19.79 89.12
60 INT135963 Negative_regulation of Hc 19 0.42 12.36 3.63 88.88
61 INT330583 Binding of EMB 1 0.07 1.23 0.22 88.08
62 INT63975 Positive_regulation of Il10 175 0.68 134.13 54.69 86.48
63 INT216985 Gene_expression of Ccl17 10 0.64 8.74 3.56 86.00
64 INT58632 Negative_regulation of Il1f5 3 0.13 3.5 0.96 85.96
65 INT2105 Negative_regulation of Rhd 10 0.41 4.9 3.4 83.92
66 INT96914 Phosphorylation of Mapk14 168 0.82 108.46 53.32 83.68
67 INT111531 Negative_regulation of Phosphorylation of Mapk14 37 0.50 20 17.68 83.68
68 INT110023 Negative_regulation of Mapk14 127 0.59 84.27 45.42 82.64
69 INT2103 Localization of Rhd 35 0.77 3.16 23.5 81.28
70 INT108588 Gene_expression of CASP3 126 0.78 84.49 16.2 81.28
71 INT88805 Protein_catabolism of CASP3 24 0.86 18.38 3.7 81.28
72 INT233650 Positive_regulation of Zbtb16 4 0.64 2.56 1.29 81.04
73 INT58192 Positive_regulation of MRI1 86 0.61 53.81 24.68 80.44
74 INT62950 Gene_expression of NPPB 73 0.75 65.91 6.54 80.36
75 INT135022 Gene_expression of Cd14 79 0.76 36.37 10.63 80.00
76 INT189791 Negative_regulation of Gene_expression of Cd14 9 0.40 4.2 0.82 80.00
77 INT93789 Gene_expression of Tnnc1 28 0.76 17.3 1.99 79.80
78 INT637 Positive_regulation of MRAP 23 0.67 21.13 9.97 79.00
79 INT116228 Binding of C1qa 26 0.47 15.72 3 78.24
80 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 78.16
81 INT194298 Gene_expression of DHPS 1 0.62 8.84 0.37 78.08
82 INT330580 Gene_expression of Eam 1 0.01 0.95 0.08 77.00
83 INT636 Binding of MRAP 54 0.48 40.36 18.77 76.80
84 INT130176 Positive_regulation of Gene_expression of CRP 125 0.66 137.06 25.9 76.60
85 INT297531 Negative_regulation of Ece1 5 0.32 5.49 0.87 76.32
86 INT98096 Positive_regulation of CHKA 14 0.42 12.23 1.61 73.44
87 INT57341 Positive_regulation of Fglu 2 0.00 1.78 0.74 72.96
88 INT19646 Binding of KLRD1 9 0.04 4.27 2.35 72.08
89 INT25613 Gene_expression of Il1f5 32 0.77 13.29 10.44 71.68
90 INT102814 Negative_regulation of CASP3 46 0.43 28.54 6.94 71.68
91 INT4137 Positive_regulation of C3 73 0.69 48.57 12.63 71.24
92 INT1123 Positive_regulation of CD79A 74 0.70 51.96 7.14 71.24
93 INT77146 Binding of IL4 23 0.36 13.69 5.39 71.20
94 INT16964 Binding of IFNG 27 0.48 14.31 2.45 71.20
95 INT222695 Binding of CLEC2B 1 0.03 0.89 0.23 71.20
96 INT79915 Positive_regulation of Agt 27 0.56 12.97 1.96 71.00
97 INT193360 Localization of LEFTY1 3 0.04 0.49 0.21 70.88
98 INT35146 Negative_regulation of PLG 27 0.57 17.63 1.98 70.76
99 INT9657 Positive_regulation of Gene_expression of Il6 237 0.70 180.45 63.6 70.24
100 INT219268 Negative_regulation of Negative_regulation of Mapk14 2 0.38 0.99 0.8 68.68
101 INT231499 Positive_regulation of Negative_regulation of Mapk14 3 0.24 1.58 0.43 68.68
102 INT23061 Binding of Erlec1 16 0.40 4.2 1.45 68.44
103 INT239060 Binding of Mbl1 5 0.32 4.89 1.27 68.44
104 INT184367 Protein_catabolism of Hc 4 0.26 2.66 0.6 68.04
105 INT15390 Positive_regulation of Edn1 64 0.70 47.36 23.8 67.92
106 INT270790 Negative_regulation of Binding of CRP 5 0.42 2.9 0.55 67.52
107 INT1149 Binding of ecs 19 0.37 13.67 3.9 66.24
108 INT170444 Binding of Gopc 172 0.39 45.05 20.71 66.20
109 INT243415 Positive_regulation of EMB 2 0.10 1.73 0.15 65.88
110 INT330581 Positive_regulation of Negative_regulation of EMB 1 0.09 0.52 0.1 65.88
111 INT330582 Negative_regulation of EMB 1 0.09 0.52 0.1 65.52
112 INT162636 Localization of PTX3 8 0.78 9.73 1.77 65.32
113 INT6364 Gene_expression of Edn1 123 0.78 73.76 28.43 64.72
114 INT17101 Positive_regulation of Gene_expression of Edn1 24 0.69 24.9 8.86 64.72
115 INT131788 Positive_regulation of NPPB 87 0.67 86.1 8.81 64.08
116 INT95565 Positive_regulation of IL12A 47 0.56 33.96 10.16 63.52
117 INT114363 Positive_regulation of Hmgb1 50 0.67 48.92 8.15 63.40
118 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 62.76
119 INT332008 Positive_regulation of Iap3ra3 1 0.01 0.96 0.07 61.72
120 INT148523 Negative_regulation of Gene_expression of Fglu 1 0.00 1.23 0.21 61.60
121 INT1125 Positive_regulation of IGHG3 130 0.69 112.07 13.18 61.12
122 INT57342 Gene_expression of Fglu 2 0.00 1.3 0.69 60.80
123 INT113948 Gene_expression of FLNA 32 0.73 36.06 4.81 59.52
124 INT68373 Negative_regulation of FLNA 59 0.57 60.46 9.55 59.52
125 INT58302 Regulation of Mpo 13 0.62 11.14 3.04 56.04
126 INT11939 Negative_regulation of Il6 138 0.59 87.46 41.24 55.96
127 INT112969 Negative_regulation of Mcpt1 30 0.45 20.17 10.11 55.96
128 INT17802 Transcription of Edn1 6 0.24 6.31 1.18 55.76
129 INT87233 Gene_expression of ECE1 12 0.65 3.54 1.12 54.88
130 INT268451 Positive_regulation of Gene_expression of ECE1 3 0.49 1.99 0.67 54.88
131 INT329319 Positive_regulation of Transcription of Ece1 1 0.08 2.64 0.48 54.48
132 INT93926 Gene_expression of Ece1 3 0.27 2.31 0.42 54.48
133 INT324886 Transcription of Ece1 2 0.37 1.95 0.4 54.48
134 INT329320 Positive_regulation of Gene_expression of Ece1 1 0.09 1.31 0.24 54.48
135 INT331761 Negative_regulation of C5ar1 3 0.08 2.65 1.25 54.32
136 INT332007 Negative_regulation of C3ar1 1 0.39 1.99 0.3 53.28
137 INT117501 Positive_regulation of Gene_expression of Adipoq 24 0.63 12.99 3.1 51.48
138 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 51.08
139 INT117500 Gene_expression of Adipoq 90 0.74 67.79 16.58 51.04
140 INT177760 Negative_regulation of Gene_expression of IFN1@ 21 0.57 16.61 2.89 50.24
141 INT76416 Positive_regulation of Gene_expression of Il5 9 0.08 4.16 1.65 50.00
142 INT39758 Gene_expression of Fn1 57 0.65 34.38 6.02 49.88
143 INT242989 Regulation of Gene_expression of Fn1 3 0.10 2.42 0.66 49.88
144 INT145001 Gene_expression of IFNB1 6 0.68 4.36 1.77 49.48
145 INT63401 Gene_expression of Il5 33 0.72 18.66 8.2 49.16
146 INT332001 Binding of C3ar1 1 0.28 2.15 0.39 48.40
147 INT320993 Regulation of C3ar1 2 0.18 1.11 0.3 48.40
148 INT69904 Binding of Hc 11 0.35 7.79 3.69 48.08
149 INT135960 Regulation of Hc 2 0.44 1.28 0.21 48.08
150 INT110020 Gene_expression of Mapk14 142 0.77 72.33 30.08 48.00
151 INT285339 Negative_regulation of Gene_expression of Dhfr 1 0.11 1.93 0.65 47.24
152 INT285337 Regulation of Gene_expression of Dhfr 1 0.11 1.93 0.65 47.24
153 INT330579 Positive_regulation of Eam 1 0.01 1.32 0.07 46.72
154 INT12290 Gene_expression of Dhfr 7 0.76 2.04 1.47 45.64
155 INT142801 Positive_regulation of Erlec1 3 0.37 0.88 0.32 45.12
156 INT3795 Positive_regulation of Ighm 46 0.68 22.43 6.47 44.08
157 INT41873 Positive_regulation of Mbl1 4 0.39 2.1 0.9 44.08
158 INT102655 Positive_regulation of Positive_regulation of Ighm 2 0.32 0.74 0.67 44.08
159 INT93045 Negative_regulation of Gene_expression of Hand2 31 0.43 25.26 9.24 42.44
160 INT141275 Negative_regulation of Gene_expression of Hand1 18 0.34 15.83 5.05 42.44
161 INT20375 Gene_expression of Hand1 213 0.60 148.51 54.53 42.00
162 INT20382 Gene_expression of Hand2 211 0.66 142.26 51.05 42.00
163 INT112017 Regulation of Hand2 77 0.36 62.23 18.04 42.00
164 INT104045 Regulation of Hand1 65 0.35 51.32 16.26 42.00
165 INT84427 Positive_regulation of Gene_expression of TSPO 15 0.64 5.05 3.58 40.92
166 INT39170 Gene_expression of TSPO 76 0.78 24.11 8.05 40.28
167 INT151274 Negative_regulation of Gene_expression of Cd40lg 3 0.32 2.16 0.3 40.24
168 INT79835 Regulation of Il10 28 0.61 21.22 11.29 39.40
169 INT85966 Gene_expression of Cd40lg 50 0.73 30.9 9.11 39.20
170 INT277486 Negative_regulation of Positive_regulation of Thbs1 1 0.43 0 0 37.92
171 INT130364 Positive_regulation of Thbs1 7 0.62 7.73 1.97 37.60
172 INT171072 Negative_regulation of Fcr 2 0.07 1.71 0.31 33.44
173 INT32389 Regulation of ecs 11 0.49 7.23 5.43 31.84
174 INT121683 Gene_expression of Hc 23 0.75 7.15 2.7 31.44
175 INT148384 Positive_regulation of HEY1 19 0.43 29.76 5.89 30.20
176 INT107448 Positive_regulation of Jak2 8 0.50 5.33 1.98 29.92
177 INT6993 Negative_regulation of Mpo 72 0.59 61.83 19.51 28.88
178 INT61519 Gene_expression of Mpo 112 0.78 89.29 18.22 28.88
179 INT108263 Negative_regulation of Gene_expression of Mpo 12 0.52 12.89 2.22 28.88
180 INT184374 Binding of Cfi 4 0.01 1.74 0.34 26.68
181 INT106525 Phosphorylation of Akt1 436 0.82 183.81 47.82 25.28
182 INT106522 Negative_regulation of Phosphorylation of Akt1 65 0.58 34.44 7.83 25.28
183 INT49214 Gene_expression of Cd4 269 0.78 154.22 34.05 22.32
184 INT117142 Gene_expression of Thbs1 58 0.72 45.02 6.51 20.16
185 INT130928 Positive_regulation of Gene_expression of Thbs1 7 0.62 5.62 1.08 20.16
186 INT8548 Gene_expression of HP 86 0.77 47.62 11.94 19.92
187 INT68187 Gene_expression of TNNT2 21 0.67 10.22 1.64 19.92
188 INT66280 Gene_expression of Nos2 534 0.78 330.78 157.07 16.72
189 INT77434 Positive_regulation of Gene_expression of Nos2 151 0.69 96.76 38.94 16.72
190 INT50879 Regulation of TNNT2 3 0.26 1.53 0.55 16.08
191 INT19185 Negative_regulation of Cd4 80 0.51 61.32 8.51 15.52
192 INT279445 Binding of C7 2 0.23 0.85 0.25 14.80
193 INT279440 Binding of C6 2 0.22 0.85 0.25 14.80
194 INT242986 Positive_regulation of Gene_expression of Nppb 3 0.26 2.77 0.5 14.60
195 INT129534 Gene_expression of Nppb 19 0.58 23.68 1.6 12.60
196 INT242985 Regulation of Gene_expression of Npr1 1 0.03 0.85 0.29 10.44
197 INT226175 Regulation of thd 8 0.14 6.8 1.42 10.40
198 INT326277 Positive_regulation of Regulation of thd 1 0.02 1.63 0.25 10.40
199 INT86705 Gene_expression of BTG3 41 0.65 37.29 8.29 9.24
200 INT9660 Regulation of TNF 363 0.62 312.94 139.99 9.04
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