D:Myoclonic Epilepsies

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Disease Term
Synonyms Absence Epilepsies Myoclonic, Absence Epilepsy Myoclonic, Astatic Epilepsies Myoclonic, Astatic Epilepsy Myoclonic, BENIGN INFANTILE MYOCLONIC EPILEPSY, CRYPTOGENIC MYOCLONIC EPILEPSIES, CRYPTOGENIC MYOCLONIC EPILEPSY, Disorder Myoclonic Seizure, Disorders Myoclonic Seizure, Early Childhood Epilepsy Myoclonic, Early Childhood Myoclonic Epilepsy
Documents 70
Hot Single Events 19
Hot Interactions 4

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Myoclonic Epilepsies. They are ordered first by their relevance to Myoclonic Epilepsies and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT262329 TRIP10 Negative_regulation of CYP2C19 1 0.01 0.8 0.26 89.12
2 INT262330 Positive_regulation of TRIP10 Negative_regulation of CYP2C19 1 0.01 0.8 0.26 89.12
3 INT262353 TRIP10 Negative_regulation of Cyp1a2 1 0.03 0.8 0.26 88.08
4 INT262354 TRIP10 Negative_regulation of Cyp4a3 1 0.00 0.8 0.26 87.44
5 INT279828 Binding of Scn1a and Scn9a 1 0.39 1.64 0.26 80.00
6 INT262336 Binding of Abat and Tmem132a 1 0.00 1.39 1.14 5.00
7 INT279829 Scn1a Regulation of Gene_expression of Scn9a 1 0.42 1.52 0.15 5.00
8 INT262335 Binding of Sv2a and Bri3 1 0.01 0.71 0.08 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Myoclonic Epilepsies. They are ordered first by their pain relevance and then by number of times they were reported in Myoclonic Epilepsies. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT153599 Gene_expression of SCN1A 8 0.75 7.01 1.47 100.00
2 INT157927 Gene_expression of Scn1a 5 0.64 6.55 2.02 99.80
3 INT956 Negative_regulation of PRL 94 0.59 42.72 23.01 99.42
4 INT915 Positive_regulation of PRL 342 0.70 141.96 104.31 98.48
5 INT1638 Negative_regulation of PLOD1 92 0.59 21.69 26.61 97.32
6 INT254045 Gene_expression of TRIP10 4 0.29 3.04 1.67 97.32
7 INT139350 Binding of SCN1B 2 0.35 1 2.43 94.04
8 INT46692 Binding of SCN9A 4 0.36 2.55 2.13 94.04
9 INT133885 Binding of SCN2A 7 0.47 1.27 1.54 94.04
10 INT139352 Binding of KCNQ2 1 0.33 0.87 0.13 94.04
11 INT139351 Binding of KCNQ3 1 0.33 0.87 0.13 94.04
12 INT262340 Binding of TRIP10 6 0.36 1.45 0.96 93.88
13 INT46460 Gene_expression of NAV1 288 0.78 135.51 305.75 91.80
14 INT111476 Gene_expression of TP63 88 0.76 61.08 11.64 91.52
15 INT74486 Positive_regulation of SCN1A 4 0.67 1 2.2 91.28
16 INT94450 Gene_expression of Nav1 359 0.78 131.85 275.46 85.64
17 INT262339 Positive_regulation of TRIP10 2 0.26 2.07 2.5 84.72
18 INT51532 Negative_regulation of Sult1a1 2 0.50 1.72 0.55 84.72
19 INT21492 Binding of Scn1a 4 0.37 2.36 2.04 80.56
20 INT59073 Gene_expression of Nae1 1 0.01 1.22 0.08 79.64
21 INT103262 Localization of Nav1 53 0.81 19.23 34.44 79.52
22 INT260050 Gene_expression of PCDH19 1 0.77 12.52 0.09 79.32
23 INT2910 Regulation of Abat 169 0.62 36.95 153.53 79.20
24 INT443 Localization of POMC 1020 0.81 284.52 443.17 78.68
25 INT234493 Gene_expression of sch 5 0.67 3.87 1.22 76.76
26 INT6967 Regulation of KCNMA1 28 0.61 3.37 4.3 74.88
27 INT11479 Positive_regulation of KCNMA1 30 0.68 10.07 10.82 71.88
28 INT260051 Positive_regulation of PCDH19 1 0.69 1.69 0 70.08
29 INT260048 Binding of PCDH19 1 0.37 4.77 0 69.84
30 INT259867 Binding of SCN1A 2 0.36 4.7 0.21 68.96
31 INT2909 Positive_regulation of Abat 334 0.70 62.1 256.43 67.52
32 INT193823 Positive_regulation of Gene_expression of TP63 7 0.18 7.74 1.57 67.40
33 INT153598 Regulation of Gene_expression of SCN1A 1 0.27 0.25 0.14 62.40
34 INT695 Binding of POMC 304 0.48 56.66 126.85 58.88
35 INT116321 Regulation of Nav1 38 0.62 26.62 37.97 58.44
36 INT279821 Regulation of Scn9a 2 0.44 2.79 0.83 58.44
37 INT262344 Negative_regulation of Lgsn 4 0.37 3.6 0.67 54.16
38 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 50.72
39 INT262343 Binding of Lgsn 6 0.32 10.1 1.65 45.00
40 INT55223 Regulation of Gene_expression of DRGX 6 0.09 3.77 5.15 44.68
41 INT55224 Gene_expression of DRGX 99 0.31 67.55 67.63 44.28
42 INT262348 Gene_expression of Lgsn 12 0.58 12.64 2.08 43.36
43 INT95167 Positive_regulation of DRGX 33 0.22 26.72 21.04 39.68
44 INT279822 Gene_expression of Scn2a1 2 0.65 1.73 1.85 34.40
45 INT279814 Gene_expression of Scn3a 1 0.50 1.63 0.05 34.00
46 INT128563 Binding of Mllt1 8 0.41 6.7 5.63 33.24
47 INT20570 Binding of PPBP 5 0.30 1.75 0.82 31.96
48 INT16460 Negative_regulation of PPBP 21 0.57 13.86 8.54 31.32
49 INT99341 Negative_regulation of Slc6a12 6 0.57 1.15 2.27 30.08
50 INT65697 Positive_regulation of GRIN3B 23 0.69 12.52 13.78 27.84
51 INT8792 Gene_expression of GBA 20 0.78 14.73 1.98 8.96
52 INT82648 Positive_regulation of Gene_expression of GBA 1 0.50 2.77 0.08 8.96
53 INT31874 Negative_regulation of Gene_expression of Abat 31 0.42 12.22 20.31 6.92
54 INT9987 Gene_expression of Abat 296 0.78 95.46 226.34 6.36
55 INT3439 Localization of Abat 1017 0.78 112.39 727.06 5.00
56 INT49750 Negative_regulation of CPOX 735 0.58 360.06 274.19 5.00
57 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
58 INT2211 Negative_regulation of Abat 267 0.59 66.51 200.98 5.00
59 INT50670 Gene_expression of CPOX 763 0.76 442.13 195.02 5.00
60 INT4829 Positive_regulation of Localization of Abat 199 0.55 20.91 150.48 5.00
61 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 5.00
62 INT2212 Binding of Abat 89 0.48 18.36 63.99 5.00
63 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 5.00
64 INT6623 Gene_expression of NA 231 0.78 45.78 59.36 5.00
65 INT129303 Positive_regulation of NAV1 54 0.70 36.92 57.45 5.00
66 INT74389 Gene_expression of Gdnf 131 0.78 58.52 57.06 5.00
67 INT42980 Gene_expression of GAD1 139 0.69 94.77 45.11 5.00
68 INT27493 Negative_regulation of Casp3 114 0.56 56.89 44.63 5.00
69 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 5.00
70 INT12228 Positive_regulation of Gene_expression of Abat 44 0.65 17.51 40.55 5.00
71 INT4449 Positive_regulation of NA 179 0.55 40.26 37.82 5.00
72 INT6417 Negative_regulation of ABAT 49 0.51 19.6 36.81 5.00
73 INT14031 Gene_expression of Npy 107 0.78 36.48 35.4 5.00
74 INT74563 Positive_regulation of Gene_expression of ROS1 258 0.61 168.18 34.08 5.00
75 INT17825 Gene_expression of Flvcr2 44 0.68 12.58 28.08 5.00
76 INT5653 Positive_regulation of ELANE 136 0.70 72.78 27.94 5.00
77 INT2912 Positive_regulation of Positive_regulation of Abat 29 0.66 6.48 27.54 5.00
78 INT63444 Regulation of Gene_expression of Abat 26 0.51 14.65 26.29 5.00
79 INT116226 Regulation of NAV1 20 0.51 14.32 25.61 5.00
80 INT256285 Gene_expression of Efnb1 32 0.70 36.25 24.73 5.00
81 INT8580 Gene_expression of ELANE 132 0.75 62.98 21.79 5.00
82 INT73625 Gene_expression of PPARG 108 0.78 104.85 21.42 5.00
83 INT105021 Binding of GOPC 187 0.40 60.39 20.38 5.00
84 INT133647 Negative_regulation of HDAC9 149 0.57 106.84 17.9 5.00
85 INT32515 Negative_regulation of B4GALNT1 82 0.43 28.1 17.46 5.00
86 INT52591 Gene_expression of KCNMA1 78 0.76 13.95 15.55 5.00
87 INT171666 Regulation of GOPC 117 0.39 40.41 15.47 5.00
88 INT71634 Gene_expression of SLC6A3 45 0.78 13.48 15.23 5.00
89 INT69435 Negative_regulation of ROS1 74 0.51 50.38 13.71 5.00
90 INT14572 Binding of INS 205 0.48 175.43 13.38 5.00
91 INT49975 Binding of SLC6A3 34 0.47 9.86 12.41 5.00
92 INT80790 Positive_regulation of Flvcr2 22 0.45 4.92 12.35 5.00
93 INT158070 Localization of Aes 23 0.65 19.93 10.9 5.00
94 INT94199 Regulation of DRGX 9 0.07 8.31 10.39 5.00
95 INT17824 Positive_regulation of Gene_expression of Flvcr2 15 0.41 6.66 10.23 5.00
96 INT167964 Gene_expression of Aes 30 0.58 25.41 10.16 5.00
97 INT67048 Gene_expression of ITGA4 58 0.75 28.93 10.16 5.00
98 INT53063 Positive_regulation of Slc1a1 10 0.70 3.23 9.89 5.00
99 INT21794 Positive_regulation of Gene_expression of Npy 20 0.70 8.44 9.3 5.00
100 INT73010 Gene_expression of Tmem132a 8 0.77 4.38 8.86 5.00
101 INT71763 Gene_expression of Mri1 33 0.58 12.56 8.6 5.00
102 INT5359 Protein_catabolism of Abat 12 0.62 5.11 8.54 5.00
103 INT150422 Positive_regulation of Aes 24 0.43 15.63 8 5.00
104 INT84162 Negative_regulation of KCNMA1 26 0.58 5.05 7.58 5.00
105 INT26462 Gene_expression of DNAH8 44 0.78 19.36 7.31 5.00
106 INT264027 Positive_regulation of Positive_regulation of Flvcr2 2 0.08 2.67 7.27 5.00
107 INT111056 Negative_regulation of Gene_expression of Flvcr2 9 0.13 4.15 7.18 5.00
108 INT52132 Positive_regulation of Negative_regulation of Abat 9 0.50 0.53 7.03 5.00
109 INT52180 Binding of Aes 38 0.42 23.16 6.7 5.00
110 INT49212 Negative_regulation of GAD1 23 0.59 22.15 6.54 5.00
111 INT60161 Gene_expression of EPHA3 43 0.75 3.66 6.25 5.00
112 INT57232 Binding of Casp3 22 0.36 9.42 6.2 5.00
113 INT95313 Gene_expression of Slc6a1 6 0.76 3.96 6.14 5.00
114 INT5490 Binding of CA2 52 0.36 9.73 5.53 5.00
115 INT146340 Localization of Mllt1 10 0.69 4.6 5.45 5.00
116 INT10100 Binding of ELANE 22 0.47 15.32 5.19 5.00
117 INT113948 Gene_expression of FLNA 32 0.73 36.06 4.81 5.00
118 INT51030 Negative_regulation of LMOD1 9 0.44 5.83 4.58 5.00
119 INT36309 Negative_regulation of DIO2 18 0.57 6.42 4.51 5.00
120 INT7083 Positive_regulation of HBM 35 0.66 20.96 4.3 5.00
121 INT146355 Negative_regulation of Aes 15 0.51 7.83 4.25 5.00
122 INT3405 Gene_expression of BCAR1 14 0.71 8.89 4.02 5.00
123 INT61495 Positive_regulation of ICA1 8 0.49 4.19 3.87 5.00
124 INT92017 Regulation of Gene_expression of Flvcr2 3 0.18 1.69 3.75 5.00
125 INT44717 Gene_expression of TNFSF14 12 0.75 13.44 3.72 5.00
126 INT267678 Positive_regulation of Positive_regulation of Slc1a1 1 0.07 1.34 3.65 5.00
127 INT12844 Binding of TP63 15 0.47 10.57 3.38 5.00
128 INT191807 Gene_expression of CD24 75 0.78 53.92 3.34 5.00
129 INT3403 Positive_regulation of BCAR1 18 0.63 18.95 3.23 5.00
130 INT25674 Positive_regulation of Gene_expression of ELANE 16 0.60 7.46 3.12 5.00
131 INT106037 Gene_expression of PEPD 10 0.75 4.18 3.11 5.00
132 INT70738 Negative_regulation of Gabrg2 7 0.57 4 2.96 5.00
133 INT45971 Negative_regulation of GOT1 9 0.51 6.2 2.84 5.00
134 INT205596 Negative_regulation of COQ10A 22 0.51 15.61 2.77 5.00
135 INT85767 Gene_expression of Scn9a 11 0.76 9.27 2.74 5.00
136 INT93207 Negative_regulation of Cyp4a3 11 0.36 4.32 2.63 5.00
137 INT205594 Gene_expression of COQ10A 19 0.67 12.53 2.56 5.00
138 INT12485 Binding of DNAH8 17 0.48 4.24 2.54 5.00
139 INT129695 Binding of Sv2a 6 0.47 4.96 2.51 5.00
140 INT6315 Regulation of Rbfox2 3 0.01 1.45 2.5 5.00
141 INT18848 Localization of LMOD1 5 0.69 1 2.49 5.00
142 INT97453 Negative_regulation of MOCS1 25 0.04 13.4 2.4 5.00
143 INT311479 Gene_expression of Mllt1 4 0.58 4.92 2.39 5.00
144 INT204175 Localization of Mri1 12 0.60 2.73 2.35 5.00
145 INT311478 Positive_regulation of Mllt1 4 0.60 2.38 2.34 5.00
146 INT161575 Localization of CACNA1A 4 0.75 5.28 2.26 5.00
147 INT98376 Gene_expression of tk 27 0.51 21.9 2.23 5.00
148 INT134944 Gene_expression of MOCS1 37 0.06 10.76 2.17 5.00
149 INT68865 Gene_expression of ACOX1 13 0.52 5.49 2.09 5.00
150 INT57431 Binding of PIAS1 4 0.30 4.35 1.94 5.00
151 INT111675 Regulation of TNFSF14 3 0.26 3.41 1.85 5.00
152 INT91550 Gene_expression of PPM1D 7 0.10 0.68 1.81 5.00
153 INT211224 Positive_regulation of Serpind1 8 0.59 12.15 1.8 5.00
154 INT157366 Positive_regulation of Positive_regulation of KCNMA1 2 0.05 2.43 1.74 5.00
155 INT122895 Transcription of DIO2 3 0.52 0.91 1.73 5.00
156 INT113985 Positive_regulation of TP63 9 0.50 8.79 1.62 5.00
157 INT309257 Transcription of LMOD1 3 0.36 1.71 1.57 5.00
158 INT130332 Gene_expression of Adam17 14 0.50 4.84 1.56 5.00
159 INT311474 Positive_regulation of Localization of Mllt1 1 0.43 1.23 1.56 5.00
160 INT144380 Gene_expression of SYNE1 12 0.58 6.99 1.55 5.00
161 INT311482 Negative_regulation of Positive_regulation of Mllt1 1 0.37 0.66 1.55 5.00
162 INT215987 Regulation of Mri1 4 0.30 2.1 1.54 5.00
163 INT311472 Negative_regulation of Localization of Mllt1 1 0.37 0.9 1.45 5.00
164 INT3404 Binding of BCAR1 10 0.33 7.97 1.33 5.00
165 INT35742 Positive_regulation of tk 8 0.43 5.53 1.33 5.00
166 INT168312 Positive_regulation of Gene_expression of EPHA3 8 0.49 0.97 1.32 5.00
167 INT311480 Negative_regulation of Mllt1 1 0.50 0.55 1.31 5.00
168 INT279823 Gene_expression of Pepd 1 0.19 2 1.14 5.00
169 INT45332 Negative_regulation of Protein_catabolism of Abat 2 0.37 1.06 1.09 5.00
170 INT106038 Regulation of PEPD 3 0.43 3.93 1.01 5.00
171 INT312392 Positive_regulation of Regulation of DRGX 1 0.05 1.51 0.94 5.00
172 INT311475 Regulation of Localization of Mllt1 1 0.39 1.1 0.94 5.00
173 INT11198 Negative_regulation of Gclc 3 0.59 0.49 0.87 5.00
174 INT264035 Regulation of Lgsn 5 0.39 6.2 0.86 5.00
175 INT130422 Positive_regulation of Gene_expression of TNFSF14 1 0.28 2.79 0.85 5.00
176 INT50687 Gene_expression of Aldoc 6 0.78 0.17 0.78 5.00
177 INT311481 Positive_regulation of Positive_regulation of Ugt1a@ 1 0.03 0.38 0.77 5.00
178 INT44293 Regulation of TP63 6 0.24 2.88 0.76 5.00
179 INT311477 Positive_regulation of Negative_regulation of Mllt1 1 0.43 0.3 0.75 5.00
180 INT128562 Regulation of Mllt1 2 0.39 1.1 0.74 5.00
181 INT272511 Positive_regulation of DMPK 8 0.54 6.85 0.72 5.00
182 INT311476 Positive_regulation of Positive_regulation of Mllt1 1 0.40 0.16 0.72 5.00
183 INT285167 Binding of PSMC4 2 0.04 0.56 0.72 5.00
184 INT311473 Positive_regulation of Ugt1a@ 1 0.04 0.38 0.7 5.00
185 INT161807 Phosphorylation of ROS1 10 0.43 4.86 0.62 5.00
186 INT86624 Binding of Efnb1 4 0.27 1.09 0.6 5.00
187 INT262352 Localization of Lgsn 3 0.60 1.49 0.6 5.00
188 INT309253 Negative_regulation of Transcription of LMOD1 1 0.03 0.2 0.57 5.00
189 INT189813 Negative_regulation of CACNA1A 4 0.57 3.07 0.55 5.00
190 INT306741 Positive_regulation of Positive_regulation of TP63 2 0.05 1.16 0.49 5.00
191 INT279818 Gene_expression of Gm4425 1 0.01 0.77 0.47 5.00
192 INT279817 Regulation of Gm4425 1 0.00 1.18 0.45 5.00
193 INT309242 Localization of Nat1 1 0.01 0.17 0.42 5.00
194 INT262351 Regulation of Localization of Mri1 1 0.02 0.82 0.37 5.00
195 INT262346 Regulation of Localization of Lgsn 1 0.31 0.8 0.37 5.00
196 INT275954 Regulation of Lat 4 0.54 0.75 0.37 5.00
197 INT274203 Positive_regulation of PABPN1 1 0.16 2.41 0.37 5.00
198 INT309244 Transcription of HSPA5 1 0.16 2.75 0.36 5.00
199 INT206440 Binding of MOCS1 13 0.01 3.76 0.35 5.00
200 INT181781 Positive_regulation of FOSB 6 0.39 4.77 0.34 5.00
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