D:Myoclonus

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Disease Term
Synonyms Action Myoclonus, Extremity Myoclonus Lower, EXTREMITY MYOCLONUS UPPER, Eyelid Myoclonus, Hiccup, HICCUPS, Intention Myoclonus, Jerk Myoclonic, Jerking Myoclonic, JERKS MYOCLONIC, Lower Extremity Myoclonus
Documents 722
Hot Single Events 87
Hot Interactions 5

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Myoclonus. They are ordered first by their relevance to Myoclonus and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT95125 Binding of KCNA6 and SGCG 1 0.40 2.73 0.18 100.00
2 INT160923 Binding of ACLS and HLA-B 1 0.03 1.44 0.29 92.40
3 INT160924 Binding of ACLS and HLA-A 1 0.01 1.44 0.29 92.40
4 INT313273 Binding of GRIN1 and MAP2 1 0.16 0.79 0.04 89.12
5 INT97043 Binding of G2e3 and Hist1h3g 1 0.01 0.5 0.36 83.20
6 INT273024 Binding of FXYD1 and RLS 1 0.04 1.24 0.21 75.56
7 INT262336 Binding of Abat and Tmem132a 1 0.00 1.39 1.14 59.60
8 INT161670 H2-M3 Positive_regulation of Positive_regulation of Mapk1 1 0.14 0.73 1.41 50.96
9 INT302712 Binding of Hprt and Hrh1 1 0.25 1.07 0.2 25.44
10 INT302711 Binding of Hrh1 and Spnb4 1 0.18 1.07 0.2 25.44
11 INT68272 Binding of Oprd1 and G2e3 1 0.00 0.11 1.93 25.00
12 INT68273 G2e3 Negative_regulation of Binding of Oprd1 and G2e3 1 0.00 0.11 1.93 25.00
13 INT70226 Binding of TAC1 and B3GAT1 4 0.24 4.5 1.26 5.00
14 INT330984 Negative_regulation of CYP2D6 Positive_regulation of Localization of CYP1A2 1 0.46 0 0.62 5.00
15 INT217760 Il1f5 Positive_regulation of Gene_expression of Cpox 1 0.00 0.27 0.47 5.00
16 INT217759 Il1f5 Positive_regulation of Cpox 1 0.00 0.27 0.47 5.00
17 INT267644 Binding of Das and RLS 1 0.06 1.04 0.35 5.00
18 INT353128 Negative_regulation of Binding of TAC1 and B3GAT1 1 0.29 1.95 0.33 5.00
19 INT190826 ELANE Positive_regulation of Localization of MUC1 1 0.07 0 0.29 5.00
20 INT262354 TRIP10 Negative_regulation of Cyp4a3 1 0.00 0.8 0.26 5.00
21 INT262353 TRIP10 Negative_regulation of Cyp1a2 1 0.03 0.8 0.26 5.00
22 INT262329 TRIP10 Negative_regulation of CYP2C19 1 0.01 0.8 0.26 5.00
23 INT262330 Positive_regulation of TRIP10 Negative_regulation of CYP2C19 1 0.01 0.8 0.26 5.00
24 INT190827 KCNA1 Regulation of Localization of MUC1 1 0.05 0.08 0.22 5.00
25 INT330986 CYP2C9 Positive_regulation of Gene_expression of CYP3A4 1 0.39 0 0.18 5.00
26 INT330985 CYP2C9 Positive_regulation of Gene_expression of CYP2C19 1 0.34 0 0.18 5.00
27 INT301782 Binding of Dmd and Utrn 1 0.24 0.15 0.18 5.00
28 INT301784 Binding of Dmd and Sntb1 1 0.05 0.36 0.16 5.00
29 INT273561 Binding of CYP1A1 and CYP3A4 1 0.02 0.12 0.15 5.00
30 INT243524 Positive_regulation of Binding of NTF3 and SOX10 1 0.01 0.54 0.14 5.00
31 INT259023 CADPS Positive_regulation of Binding of SH2B2 1 0.06 2.05 0.14 5.00
32 INT243525 Binding of NTF3 and SOX10 1 0.01 0.54 0.14 5.00
33 INT301783 Binding of Dtna and Sntb1 1 0.01 0.05 0.12 5.00
34 INT301788 Binding of Dmd and Dtna 1 0.09 0.05 0.12 5.00
35 INT301789 Binding of Sntb1 and Utrn 1 0.03 0.05 0.12 5.00
36 INT262335 Binding of Sv2a and Bri3 1 0.01 0.71 0.08 5.00
37 INT250153 Binding of PRNP and IKBKG 1 0.09 2.83 0.06 5.00
38 INT250150 Binding of IKBKG and SACM1L 1 0.00 2.78 0.06 5.00
39 INT251944 Binding of GH1 and PRNP 1 0.09 1.14 0.05 5.00
40 INT319111 Binding of Yy1 and Sap30 1 0.01 0 0.04 5.00
41 INT250151 Binding of GSS and MCM3 1 0.01 1.38 0.04 5.00
42 INT301786 Negative_regulation of Binding of Dmd and Sntb1 1 0.06 0.31 0.04 5.00
43 INT319094 Binding of polymerase and RNPC3 1 0.00 0.13 0 5.00
44 INT313271 Binding of GRIN1 and GRIN2B 1 0.24 0.06 0 5.00
45 INT313272 Binding of DLG4 and GRIN1 1 0.09 0.06 0 5.00
46 INT301787 Dtna Regulation of Prkx 1 0.00 0.1 0 5.00
47 INT250152 Binding of APOE and UBE4B 1 0.21 1.2 0 5.00
48 INT354482 Binding of PRNP and Prnp 1 0.16 0.88 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Myoclonus. They are ordered first by their pain relevance and then by number of times they were reported in Myoclonus. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT21131 Negative_regulation of Gene_expression of ABAT 6 0.42 4.93 2.83 99.92
2 INT13530 Negative_regulation of GABRB3 4 0.17 1.48 1.31 99.92
3 INT153599 Gene_expression of SCN1A 8 0.75 7.01 1.47 99.80
4 INT21132 Gene_expression of GABRB3 36 0.33 11.32 17.61 99.44
5 INT15652 Positive_regulation of ENO2 37 0.68 33.39 5.02 99.34
6 INT22962 Gene_expression of FXYD1 2 0.58 3.32 1.12 99.20
7 INT23212 Positive_regulation of Rac1 46 0.55 32.85 15.1 99.12
8 INT35584 Binding of ACLY 22 0.35 31.78 7.17 98.96
9 INT5916 Positive_regulation of HTR1A 51 0.67 18.27 21.38 98.94
10 INT50055 Negative_regulation of Rac1 36 0.50 19.74 8.98 98.84
11 INT18981 Gene_expression of ABAT 78 0.68 38.35 61.36 98.68
12 INT21130 Positive_regulation of GABRB3 4 0.27 1.88 2.21 98.12
13 INT75742 Binding of RLS 86 0.42 95.27 19.04 97.94
14 INT97062 Binding of PML 10 0.41 11.63 1.65 97.80
15 INT324672 Negative_regulation of Gene_expression of CEBPZ 2 0.36 2.75 0.48 97.72
16 INT78562 Gene_expression of Rhox8 1 0.15 1.12 0.42 97.64
17 INT45012 Negative_regulation of Azi1 1 0.37 0.18 0.43 97.60
18 INT97042 Positive_regulation of Hist1h3g 1 0.15 0.49 0.25 97.28
19 INT11077 Positive_regulation of Htr3a 63 0.67 15.61 22.7 97.12
20 INT22450 Gene_expression of GPI 31 0.58 18.77 6.71 97.08
21 INT16395 Gene_expression of CEBPZ 30 0.57 11.02 6.66 97.00
22 INT7000 Positive_regulation of Htr2a 42 0.67 9.48 18.7 96.72
23 INT86462 Transcription of Drd1a 3 0.44 1.86 2.36 96.28
24 INT886 Gene_expression of Pomc 676 0.78 129.87 295.98 96.20
25 INT8531 Transcription of PDYN 56 0.72 19.51 30.99 95.40
26 INT57721 Localization of CCT6A 2 0.16 3.12 5.88 95.20
27 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 94.96
28 INT9098 Positive_regulation of DBP 30 0.69 15.77 4.26 94.92
29 INT28326 Positive_regulation of Negative_regulation of Oprl1 6 0.44 2.01 3.78 94.44
30 INT2761 Regulation of Gabrg1 119 0.61 18.8 60.52 94.16
31 INT150323 Gene_expression of Cstb 5 0.67 3.31 0.52 94.04
32 INT46273 Gene_expression of PRNP 103 0.78 110.34 9.25 93.92
33 INT1335 Negative_regulation of Oprl1 123 0.59 18.02 77.13 93.92
34 INT1080 Negative_regulation of Ache 343 0.59 108.51 72.4 93.92
35 INT647 Gene_expression of SGCG 211 0.75 78.46 55.82 93.72
36 INT1125 Positive_regulation of IGHG3 130 0.69 112.07 13.18 93.20
37 INT18513 Binding of GRIN1 32 0.47 9.44 15.08 93.20
38 INT48541 Positive_regulation of Kcna5 12 0.69 5.51 6.35 92.98
39 INT95128 Positive_regulation of KCNA1 8 0.41 4.28 2.19 92.98
40 INT95130 Positive_regulation of KCNA6 1 0.21 2.35 0.16 92.98
41 INT17511 Negative_regulation of PRTN3 19 0.41 12 3.3 92.80
42 INT48390 Negative_regulation of Localization of CSF2 10 0.51 7.39 3.28 92.36
43 INT66002 Binding of LAMC2 9 0.47 4.5 2.54 92.24
44 INT54565 Binding of SCLC1 12 0.31 20.41 0.81 91.96
45 INT14690 Localization of CSF2 124 0.80 85.17 27.26 91.32
46 INT28929 Negative_regulation of PVR 22 0.57 16.64 1.07 90.88
47 INT119348 Binding of IKBKG 7 0.15 4.03 1.14 89.80
48 INT34720 Positive_regulation of SHBG 58 0.69 32.4 3.83 89.36
49 INT17033 Positive_regulation of Trf 21 0.62 11.76 2.68 89.12
50 INT7056 Positive_regulation of Gene_expression of PENK 35 0.70 14.31 18.21 88.72
51 INT2289 Gene_expression of PENK 203 0.78 55.62 79.49 88.24
52 INT232663 Positive_regulation of CCT6A 1 0.13 3.08 5.27 88.04
53 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 87.92
54 INT246641 Gene_expression of YWHAQ 5 0.58 3 0.22 87.92
55 INT111675 Regulation of TNFSF14 3 0.26 3.41 1.85 87.84
56 INT4029 Positive_regulation of HYAL1 10 0.69 2 1.39 87.80
57 INT5660 Binding of Oprd1 477 0.48 71.86 342.06 87.12
58 INT70522 Binding of Kcna1 2 0.36 0.73 2.22 86.92
59 INT40857 Positive_regulation of MAOA 6 0.49 2.51 1.71 86.84
60 INT41892 Gene_expression of HBM 48 0.64 28.32 5.64 86.80
61 INT160925 Transcription of HLA-A 1 0.31 1.41 0.24 86.80
62 INT59073 Gene_expression of Nae1 1 0.01 1.22 0.08 86.76
63 INT16455 Gene_expression of Drd2 116 0.78 22.71 38.47 86.56
64 INT914 Positive_regulation of GH1 292 0.69 100.7 84.91 86.52
65 INT11696 Gene_expression of HLA-A 50 0.78 41.25 14.1 86.16
66 INT78564 Positive_regulation of Rhox8 1 0.10 1.1 0.31 85.92
67 INT25 Positive_regulation of LAMC2 19 0.67 8.64 7.06 85.84
68 INT207867 Gene_expression of H2-Ob 1 0.01 5.46 0.18 85.76
69 INT27627 Binding of Rac1 41 0.41 22.88 13.68 85.60
70 INT13240 Gene_expression of TF 94 0.76 57.81 10.99 85.12
71 INT93490 Gene_expression of GPM6A 14 0.69 3.14 9.08 84.96
72 INT232661 Negative_regulation of Gene_expression of GPM6A 1 0.02 0.81 1.2 84.96
73 INT86464 Binding of LMOD1 31 0.44 10.23 10.46 84.52
74 INT130344 Gene_expression of APOH 3 0.34 2.87 0.32 84.48
75 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 84.16
76 INT78024 Gene_expression of ACLY 73 0.75 59.15 18.54 84.16
77 INT1934 Positive_regulation of Cys1 68 0.68 60.56 10.47 83.92
78 INT16996 Gene_expression of PRTN3 113 0.75 85.61 22.57 83.80
79 INT47030 Negative_regulation of ARMC9 22 0.38 13.08 0.47 82.40
80 INT25971 Positive_regulation of EBI3 5 0.19 5.01 1.07 82.24
81 INT1878 Binding of HLA-B 440 0.48 321.16 127.36 81.92
82 INT179379 Positive_regulation of Positive_regulation of GPM6A 1 0.07 0.58 1.37 81.36
83 INT135219 Binding of Polg 1 0.08 1.04 0.08 80.80
84 INT22939 Gene_expression of Csf2 164 0.78 85.1 32.22 80.76
85 INT177328 Positive_regulation of CXADR 9 0.48 4.29 2.27 80.24
86 INT130422 Positive_regulation of Gene_expression of TNFSF14 1 0.28 2.79 0.85 80.16
87 INT44717 Gene_expression of TNFSF14 12 0.75 13.44 3.72 80.16
88 INT19330 Binding of HLA-A 99 0.48 76.26 22.85 79.88
89 INT22516 Gene_expression of H2-M3 17 0.25 2.98 13.59 79.68
90 INT8683 Positive_regulation of F3 31 0.67 42.89 6.21 79.68
91 INT95696 Gene_expression of Dmd 130 0.68 26.02 5.34 79.48
92 INT51779 Gene_expression of Drd1a 46 0.66 11.18 17.51 79.40
93 INT67855 Negative_regulation of PPIG 64 0.57 17.83 13.54 79.24
94 INT119187 Gene_expression of HLA-DRB5 5 0.02 4.47 1.18 78.80
95 INT49441 Negative_regulation of Cpox 494 0.59 303.22 177.46 78.44
96 INT259867 Binding of SCN1A 2 0.36 4.7 0.21 78.00
97 INT86461 Positive_regulation of Binding of Slc37a4 1 0.02 0.57 0.51 77.64
98 INT302707 Phosphorylation of Spnb4 1 0.28 3.13 0 76.76
99 INT113438 Positive_regulation of GPM6A 3 0.11 3.26 2.29 76.48
100 INT42980 Gene_expression of GAD1 139 0.69 94.77 45.11 76.44
101 INT86460 Binding of Slc37a4 5 0.04 1.8 2.08 76.44
102 INT167964 Gene_expression of Aes 30 0.58 25.41 10.16 76.08
103 INT1792 Positive_regulation of CGA 123 0.70 64.73 20.79 75.96
104 INT86463 Regulation of Gene_expression of Hbegf 1 0.05 0.59 0.26 75.12
105 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82 74.32
106 INT130837 Gene_expression of Aqp4 205 0.78 151.23 29.63 74.16
107 INT169748 Positive_regulation of Gene_expression of Aqp4 38 0.69 34.29 3.79 74.16
108 INT130343 Gene_expression of CTNND2 5 0.75 6.98 1.38 73.64
109 INT78561 Gene_expression of Hbegf 4 0.56 2.65 0.97 73.28
110 INT70265 Regulation of MRI1 42 0.39 30.95 14.18 73.28
111 INT48767 Negative_regulation of NOS1 312 0.59 154.25 90.32 73.24
112 INT260050 Gene_expression of PCDH19 1 0.77 12.52 0.09 72.40
113 INT50580 Binding of PPIG 39 0.36 11.17 12.34 71.80
114 INT11685 Regulation of CSF2 99 0.59 58.82 15.9 71.36
115 INT49813 Gene_expression of Ptz1a 5 0.49 2.8 2.39 70.96
116 INT120665 Binding of TACC2 4 0.07 4.33 0.46 70.96
117 INT102112 Gene_expression of Prnp 440 0.78 209.32 22.5 70.64
118 INT142735 Regulation of RLS 33 0.53 45.83 11.35 70.28
119 INT47459 Gene_expression of Rac1 101 0.68 45.27 24.33 69.76
120 INT168290 Gene_expression of HIST1H3G 1 0.07 0.13 0 69.44
121 INT75682 Regulation of Chrna7 14 0.45 10.24 5.25 69.36
122 INT260048 Binding of PCDH19 1 0.37 4.77 0 69.20
123 INT20260 Positive_regulation of Chkb 41 0.64 21.48 18.53 69.12
124 INT273027 Regulation of Negative_regulation of FXYD1 1 0.05 1.19 0.35 69.12
125 INT19396 Regulation of Rac1 66 0.53 37.41 30.01 68.96
126 INT185498 Regulation of Positive_regulation of ENO2 1 0.26 0.5 0.1 68.72
127 INT247999 Negative_regulation of FXYD1 2 0.06 1.75 0.35 68.60
128 INT101013 Regulation of HLA-A 7 0.33 6.7 1.8 67.68
129 INT92434 Phosphorylation of Mapk1 287 0.82 91.65 83.46 66.56
130 INT1793 Localization of CGA 379 0.81 67.38 114.69 65.96
131 INT6822 Gene_expression of Pdyn 215 0.78 35.99 125.76 65.92
132 INT217758 Regulation of Kcnd3 1 0.00 0.69 0.82 65.12
133 INT200435 Binding of polymerase 6 0.16 5.56 0.47 64.20
134 INT10847 Gene_expression of LAMC2 39 0.75 27 12.09 63.52
135 INT22369 Negative_regulation of Drd1a 15 0.47 6.13 6.87 63.32
136 INT260051 Positive_regulation of PCDH19 1 0.69 1.69 0 63.16
137 INT164254 Gene_expression of Dnaja3 1 0.57 1.1 1.83 62.76
138 INT6302 Binding of IFNA1 196 0.48 133.85 32.73 62.44
139 INT86488 Gene_expression of Kcnc1 34 0.66 3.58 4.72 61.52
140 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98 61.36
141 INT202817 Gene_expression of Dag1 16 0.75 7.82 1.3 61.20
142 INT277821 Positive_regulation of Negative_regulation of INCENP 2 0.03 0.89 0.12 60.84
143 INT38283 Positive_regulation of Cebpg 2 0.04 1.96 0.69 60.64
144 INT262343 Binding of Lgsn 6 0.32 10.1 1.65 60.32
145 INT172551 Negative_regulation of INCENP 38 0.07 20.83 3.14 59.96
146 INT41296 Protein_catabolism of Oprd1 8 0.85 0.79 3.48 59.60
147 INT218611 Gene_expression of Kcna3 1 0.02 0.34 0.26 59.52
148 INT19804 Negative_regulation of Hprt 18 0.59 20.6 2.17 59.36
149 INT60864 Regulation of G2e3 4 0.21 0.64 2.54 59.04
150 INT78563 Gene_expression of Tox 2 0.65 1.44 0.24 58.56
151 INT4686 Gene_expression of Cys1 32 0.66 36.24 2.49 57.16
152 INT218612 Negative_regulation of Kcna3 1 0.01 0.68 0.54 57.12
153 INT285294 Localization of RCVRN 1 0.01 2.56 0 57.12
154 INT197721 Positive_regulation of ARMC9 36 0.35 20.08 1.03 57.00
155 INT57232 Binding of Casp3 22 0.36 9.42 6.2 56.40
156 INT127435 Gene_expression of Per1 89 0.77 13.94 22.31 55.36
157 INT73010 Gene_expression of Tmem132a 8 0.77 4.38 8.86 55.36
158 INT167203 Binding of PRNP 25 0.48 20.09 1.84 54.72
159 INT179175 Positive_regulation of Asl 1 0.38 0.39 0.09 54.68
160 INT207780 Positive_regulation of NMS 2 0.28 3.2 0.61 50.20
161 INT98068 Gene_expression of SCN2A 19 0.75 14.42 3.31 50.00
162 INT89834 Positive_regulation of SCN2A 8 0.49 1.89 2.77 50.00
163 INT169864 Positive_regulation of Gene_expression of SCN2A 1 0.45 0.38 0 50.00
164 INT95787 Positive_regulation of Mapk1 568 0.70 226.51 220.94 49.80
165 INT9131 Positive_regulation of Prkcg 431 0.70 130.8 302.41 49.60
166 INT232667 Binding of Pd 17 0.16 20.76 3.58 48.68
167 INT77084 Gene_expression of Hist1h3g 3 0.54 0 0.35 48.32
168 INT260047 Regulation of PCDH19 1 0.45 1.43 0 47.84
169 INT260049 Negative_regulation of PCDH19 1 0.58 4.41 0.04 47.76
170 INT87963 Regulation of Tg 3 0.45 2.7 0.32 47.44
171 INT123463 Gene_expression of ATP5G3 5 0.37 2.25 0.75 47.36
172 INT83468 Gene_expression of ELK3 22 0.66 2.91 2.03 47.20
173 INT4345 Gene_expression of Gtf3a 157 0.67 80.75 48.47 46.96
174 INT67912 Gene_expression of GRIN1 75 0.77 28.99 29.28 46.60
175 INT154455 Gene_expression of dds 4 0.58 3.84 0.46 46.48
176 INT28001 Gene_expression of Gpm6a 23 0.66 16.66 21.09 46.24
177 INT60865 Gene_expression of G2e3 20 0.73 2.1 12.76 46.24
178 INT27798 Gene_expression of Ntrk2 111 0.78 56.08 42.68 45.28
179 INT4403 Binding of CYP2B6 113 0.48 21.17 33.83 45.28
180 INT50579 Binding of CYP3A4 84 0.48 17.52 17.45 45.28
181 INT189813 Negative_regulation of CACNA1A 4 0.57 3.07 0.55 44.64
182 INT175961 Protein_catabolism of polymerase 5 0.08 1.94 0.19 42.88
183 INT283119 Regulation of Dag1 4 0.44 1.98 0.65 41.96
184 INT283120 Regulation of Gene_expression of Dag1 4 0.52 1.32 0.38 41.96
185 INT97308 Gene_expression of TPO 15 0.65 13.26 2.12 41.84
186 INT18121 Binding of Maoa 20 0.48 2.4 9.3 41.28
187 INT309248 Negative_regulation of ATXN8OS 1 0.06 1.49 0 40.72
188 INT205596 Negative_regulation of COQ10A 22 0.51 15.61 2.77 39.52
189 INT164193 Localization of ATN1 2 0.73 1.47 0.03 37.52
190 INT309258 Localization of TBP 2 0.27 1.78 0.03 36.64
191 INT6601 Gene_expression of PPAP2A 21 0.27 3.13 5.52 36.40
192 INT199419 Negative_regulation of Gene_expression of PPAP2A 1 0.03 0.21 0.11 36.40
193 INT114524 Binding of GRIN2B 3 0.36 0.44 0.74 36.24
194 INT106023 Localization of PPIG 8 0.57 4.08 0.96 36.16
195 INT309256 Localization of ATXN7 1 0.11 1.46 0.03 36.08
196 INT3593 Gene_expression of ADRA1D 70 0.75 29.48 20.87 35.68
197 INT6521 Negative_regulation of Gene_expression of ADRA1D 4 0.57 3.19 2.14 35.68
198 INT202715 Binding of NMS 3 0.27 6.92 0.65 35.68
199 INT161575 Localization of CACNA1A 4 0.75 5.28 2.26 35.60
200 INT309250 Localization of ATXN3 1 0.14 1.46 0.03 35.12
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