D:Myotonic Dystrophy

From wiki-pain
Jump to: navigation, search

pChart

Disease Term
Synonyms CONGENITAL MYOTONIC DYSTROPHIES, CONGENITAL MYOTONIC DYSTROPHY, Curschmann Batten Steinert Syndrome, Dystrophia Myotonica, Dystrophies Congenital Myotonic, Dystrophies Myotonic, Dystrophy Congenital Myotonic, DYSTROPHY MYOTONIC, Myotonia Atrophica, Myotonia Dystrophica, Myotonic Dystrophies
Documents 41
Hot Single Events 27
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Myotonic Dystrophy. They are ordered first by their relevance to Myotonic Dystrophy and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT272522 Celf1 Positive_regulation of Phosphorylation of CEBPD 1 0.03 0.52 0 80.52
2 INT272524 DICER1 Negative_regulation of Dmpk 1 0.04 0.07 0 75.00
3 INT311394 Binding of Celf1 and Eif2s2 1 0.12 1.67 0 69.60
4 INT311389 Positive_regulation of Binding of Celf1 and Eif2s2 1 0.17 0.59 0 69.60
5 INT311381 Phosphorylation of Akt1 Regulation of Celf1 1 0.10 0.14 0 60.52
6 INT311396 Akt1 Regulation of Celf1 1 0.04 0.14 0 59.36
7 INT311405 CCND3 Regulation of Celf1 1 0.41 0.14 0 59.04
8 INT311403 CDKN2A Regulation of Celf1 1 0.41 0.14 0 58.68
9 INT311385 Gopc Regulation of Celf1 1 0.04 0.14 0 58.20
10 INT311298 Binding of DMPK and Mbnl1 1 0.43 0.54 0 52.92
11 INT311399 Binding of Celf1 and Uts2r 1 0.08 0.26 0.12 50.00
12 INT272517 Binding of Ccnd1 and Celf1 3 0.08 0.07 0 50.00
13 INT311390 Mbnl1 Positive_regulation of Celf1 1 0.26 0.48 0 50.00
14 INT311387 Binding of Celf1 and Mbnl1 1 0.20 0.25 0 50.00
15 INT272514 Cdk4 Positive_regulation of Phosphorylation of Ccnd3 1 0.01 0 0 50.00
16 INT272523 Binding of DMPK and Gtf3a 1 0.00 0.81 0 50.00
17 INT311404 Binding of CDKN2A and Celf1 1 0.32 0.07 0 50.00
18 INT272518 Positive_regulation of Binding of Ccnd1 and Celf1 1 0.01 0 0 50.00
19 INT272513 Binding of Mef2a and Eif2s2 1 0.03 0 0 50.00
20 INT311379 Celf1 Negative_regulation of Mbnl1 1 0.24 0.26 0 50.00
21 INT311384 Binding of Cnbp and Eef2 1 0.07 0.15 0 50.00
22 INT311398 Positive_regulation of Celf1 Positive_regulation of Hdac1 1 0.12 0.19 0 50.00
23 INT272516 Binding of Celf1 and Tpt1 2 0.05 0.07 0 50.00
24 INT311380 Positive_regulation of Celf1 Negative_regulation of Mbnl1 1 0.26 0.26 0 50.00
25 INT311393 Binding of Eef2 and Rps17 1 0.02 0.15 0 50.00
26 INT311392 Binding of Cnbp and Pabpc1 1 0.04 0.14 0 50.00
27 INT311397 Binding of Celf1 and Gopc 1 0.04 0.09 0 50.00
28 INT311378 Binding of Cnbp and Rps17 1 0.06 0.14 0 50.00
29 INT311375 Phosphorylation of Prkca Positive_regulation of Celf1 1 0.04 0.1 0 50.00
30 INT272520 Gene_expression of Dmpk Positive_regulation of Positive_regulation of Nkx2-5 1 0.02 0.43 0 50.00
31 INT311402 Binding of Celf1 and Eif2s2 Positive_regulation of Phosphorylation of Celf1 1 0.11 0.22 0 50.00
32 INT272525 Phosphorylation of Celf1 Positive_regulation of Binding of Celf1 and Tpt1 1 0.03 0 0 50.00
33 INT272515 Akt1 Positive_regulation of Binding of Celf1 1 0.03 0 0 50.00
34 INT311391 Binding of Celf1 and Dmpk 1 0.34 0.09 0 50.00
35 INT311395 Binding of Esr1 and 20S 1 0.04 0.11 0 50.00
36 INT311383 Mbnl1 Regulation of Insr 1 0.00 0.24 0 50.00
37 INT272521 Binding of DMPK and Nkx2-5 1 0.01 0.42 0 50.00
38 INT311376 Binding of Ccnd3 and Celf1 1 0.06 0.07 0 50.00
39 INT311386 Celf1 Regulation of Insr 1 0.00 0.24 0 50.00
40 INT311388 Mbnl1 Positive_regulation of Binding of Celf1 1 0.26 0.13 0 50.00
41 INT311377 Binding of Eef2 and Pabpc1 1 0.01 0.15 0 50.00
42 INT271071 Binding of ACTA1 and Hypism 1 0.00 1.54 0.15 5.00
43 INT311296 Akt1 Positive_regulation of Gene_expression of Clcn1 1 0.11 0 0.05 5.00
44 INT311295 Gopc Positive_regulation of Gene_expression of Clcn1 1 0.07 0.29 0 5.00
45 INT289878 Binding of MMD and SEPN1 1 0.16 1.27 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Myotonic Dystrophy. They are ordered first by their pain relevance and then by number of times they were reported in Myotonic Dystrophy. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT211584 Gene_expression of Dmpk 32 0.73 12.28 0.46 100.00
2 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 100.00
3 INT255133 Gene_expression of Six5 2 0.58 2.52 0.06 100.00
4 INT255122 Gene_expression of Mypop 2 0.11 1.78 0.06 100.00
5 INT251238 Gene_expression of Lvs 35 0.32 29.41 1.59 100.00
6 INT2090 Negative_regulation of Gaa 5 0.21 3.43 0.4 99.76
7 INT255120 Gene_expression of Celf1 29 0.62 10.82 0.59 99.72
8 INT272467 Positive_regulation of Phosphorylation of Celf1 3 0.56 1.61 0.05 99.48
9 INT272486 Phosphorylation of Celf1 10 0.66 4.63 0.08 98.76
10 INT272511 Positive_regulation of DMPK 8 0.54 6.85 0.72 97.12
11 INT2597 Negative_regulation of ACHE 82 0.59 46.36 8.62 96.96
12 INT277278 Regulation of Celf1 4 0.49 4.63 0.48 96.00
13 INT272475 Regulation of Mbnl1 15 0.61 5.39 0.56 93.04
14 INT311289 Regulation of CELF1 1 0.15 1.78 0.03 93.04
15 INT311291 Regulation of MBNL1 1 0.02 0.69 0 93.04
16 INT97777 Positive_regulation of CNBP 7 0.37 9.85 1.09 90.72
17 INT272471 Binding of Celf1 5 0.39 4.97 0.56 90.04
18 INT255101 Positive_regulation of Celf1 23 0.56 11.91 0.84 89.44
19 INT277269 Positive_regulation of Binding of Celf1 2 0.40 0.89 0.24 89.44
20 INT311305 Positive_regulation of Eif2s2 1 0.19 0.57 0.03 89.44
21 INT311319 Positive_regulation of Binding of Eif2s2 1 0.14 0.51 0 89.44
22 INT272470 Binding of Eif2s2 2 0.10 0.95 0 88.32
23 INT311310 Regulation of Binding of Celf1 1 0.36 0.88 0 87.16
24 INT75136 Binding of Akt1 27 0.27 8.81 4.15 82.56
25 INT311364 Binding of CCND3 1 0.36 0.47 0 82.56
26 INT272501 Positive_regulation of Phosphorylation of CEBPD 1 0.06 0.52 0 80.88
27 INT272510 Phosphorylation of CEBPD 1 0.10 0.52 0 80.52
28 INT26678 Negative_regulation of Dmpk 11 0.47 3.45 0.26 79.52
29 INT272472 Phosphorylation of Dmpk 2 0.72 1.05 0 77.80
30 INT75137 Regulation of Akt1 74 0.48 37.89 9.7 76.24
31 INT255102 Transcription of Dmpk 8 0.60 2.47 0.03 75.76
32 INT712 Positive_regulation of LDHA 160 0.70 175.25 19.11 75.76
33 INT711 Positive_regulation of PIK3C2A 83 0.70 76.87 13.18 75.76
34 INT272487 Transcription of Mbnl1 1 0.54 0.48 0 75.00
35 INT528 Gene_expression of Prl 693 0.78 217.18 192.2 75.00
36 INT272481 Negative_regulation of Phosphorylation of Dmpk 1 0.41 0.44 0 75.00
37 INT272459 Negative_regulation of Phosphorylation of Celf1 2 0.47 0.55 0 75.00
38 INT272506 Negative_regulation of Localization of DMPK 1 0.29 0.41 0 75.00
39 INT272473 Negative_regulation of Localization of Mef2a 1 0.23 0.41 0 75.00
40 INT272460 Negative_regulation of Localization of Tpt1 1 0.11 0.41 0 75.00
41 INT272509 Localization of DMPK 6 0.58 1.52 0.03 75.00
42 INT169916 Localization of Tpt1 5 0.31 1.27 0 75.00
43 INT272468 Localization of Mef2a 1 0.40 0.4 0 75.00
44 INT272502 Transcription of DICER1 3 0.08 2.14 0.39 75.00
45 INT255110 Binding of Dmpk 9 0.39 1.41 0.11 75.00
46 INT48555 Binding of SP1 30 0.46 11.38 6.53 75.00
47 INT173632 Transcription of SP1 7 0.41 1.42 0.09 75.00
48 INT48554 Positive_regulation of SP1 12 0.49 3.64 1.2 75.00
49 INT3527 Regulation of RNASE1 3 0.15 1.22 0.33 75.00
50 INT272508 Regulation of DICER1 4 0.11 1.21 0.05 75.00
51 INT57442 Phosphorylation of Prkca 98 0.70 31.58 41.04 71.96
52 INT64159 Gene_expression of Prkca 90 0.78 34.65 55.97 71.96
53 INT76466 Regulation of Gene_expression of Prkca 6 0.45 0.94 3.91 71.96
54 INT260581 Binding of DMPK 7 0.43 5.09 0.28 70.64
55 INT311341 Regulation of Binding of Eif2s2 1 0.11 0.39 0 69.60
56 INT272479 Regulation of Dmpk 2 0.50 0.45 0 67.88
57 INT121496 Gene_expression of TERT 107 0.78 45.6 7.42 67.80
58 INT129712 Positive_regulation of Gene_expression of TERT 12 0.70 7.3 1.44 67.80
59 INT311326 Positive_regulation of Gene_expression of Ccnd3 1 0.09 0.43 0 66.32
60 INT196430 Gene_expression of Ccnd3 5 0.14 1.92 0 65.60
61 INT106525 Phosphorylation of Akt1 436 0.82 183.81 47.82 65.16
62 INT116314 Gene_expression of Myod1 38 0.70 16.6 0.89 64.64
63 INT146784 Gene_expression of MYOD1 13 0.74 4.41 0.54 64.64
64 INT272507 Binding of PRKRIR 1 0.02 0.5 0 64.64
65 INT251025 Phosphorylation of CDKN2A 4 0.61 3.19 0.32 60.52
66 INT306876 Phosphorylation of CCND3 2 0.35 0.21 0 60.52
67 INT255128 Binding of Mbnl1 13 0.37 4.34 0.09 52.72
68 INT5033 Negative_regulation of tf 39 0.54 13.37 48.62 50.00
69 INT23224 Gene_expression of tf 99 0.56 60.22 22.03 50.00
70 INT69878 Positive_regulation of Gene_expression of Gtf3a 48 0.29 36.78 13.57 50.00
71 INT17584 Regulation of tf 12 0.50 4.69 10.39 50.00
72 INT114874 Gene_expression of Stat3 78 0.76 53.99 9.49 50.00
73 INT92138 Binding of CDKN2A 28 0.37 25.64 7.47 50.00
74 INT48239 Binding of Gtf3a 52 0.33 23.14 6.45 50.00
75 INT138915 Gene_expression of Stat1 144 0.77 69.53 5.85 50.00
76 INT57441 Positive_regulation of Phosphorylation of Prkca 9 0.40 2.72 4.89 50.00
77 INT123411 Gene_expression of Sp1 15 0.69 4.2 3.79 50.00
78 INT119839 Gene_expression of STAT1 17 0.75 8.36 2.7 50.00
79 INT24902 Gene_expression of SP1 17 0.71 8.11 2.58 50.00
80 INT166820 Gene_expression of CLCN1 3 0.38 2.38 2.04 50.00
81 INT89865 Gene_expression of Nkx2-5 14 0.75 2.99 1.58 50.00
82 INT19342 Regulation of Insr 12 0.24 6.11 1.54 50.00
83 INT16178 Gene_expression of Clcn1 20 0.69 8.67 1.46 50.00
84 INT16854 Gene_expression of Uts2r 17 0.26 3.1 1.31 50.00
85 INT19044 Positive_regulation of GGT5 10 0.65 7.7 1.11 50.00
86 INT55294 Gene_expression of Slc2a4 17 0.70 6.84 1.11 50.00
87 INT144465 Gene_expression of DMPK 9 0.69 5.01 0.94 50.00
88 INT109007 Positive_regulation of Ccnd1 23 0.53 9.5 0.86 50.00
89 INT123410 Negative_regulation of Gene_expression of Sp1 3 0.38 1.01 0.82 50.00
90 INT114877 Gene_expression of Cdk4 12 0.69 5.98 0.79 50.00
91 INT124850 Gene_expression of Tpt1 42 0.77 14.51 0.79 50.00
92 INT24905 Negative_regulation of Gene_expression of SP1 4 0.39 2.05 0.65 50.00
93 INT228246 Negative_regulation of Gene_expression of Stat3 10 0.58 8.11 0.64 50.00
94 INT255131 Gene_expression of Mbnl1 34 0.77 10.44 0.55 50.00
95 INT255113 Positive_regulation of Gene_expression of Mbnl1 15 0.69 3.28 0.47 50.00
96 INT255112 Negative_regulation of Mbnl1 22 0.58 8.5 0.45 50.00
97 INT255135 Positive_regulation of Gene_expression of Celf1 18 0.56 5.84 0.43 50.00
98 INT245262 Negative_regulation of Gene_expression of Stat1 9 0.42 2.87 0.42 50.00
99 INT189755 Gene_expression of CCND3 42 0.65 10.88 0.39 50.00
100 INT211586 Regulation of DMPK 6 0.31 2.11 0.33 50.00
101 INT124851 Negative_regulation of Tpt1 13 0.43 2.92 0.32 50.00
102 INT255132 Positive_regulation of Mbnl1 15 0.54 2.58 0.27 50.00
103 INT208915 Positive_regulation of Nkx2-5 3 0.29 1.02 0.25 50.00
104 INT255123 Localization of Mbnl1 7 0.80 3.76 0.24 50.00
105 INT272484 Negative_regulation of Myod1 8 0.39 6.77 0.2 50.00
106 INT271731 Binding of 20S 4 0.47 2.12 0.18 50.00
107 INT231559 Negative_regulation of Gene_expression of STAT1 2 0.06 0.36 0.14 50.00
108 INT232584 Transcription of DMPK 5 0.47 3.41 0.13 50.00
109 INT146415 Regulation of Nkx2-5 3 0.44 0.91 0.13 50.00
110 INT255100 Positive_regulation of Gene_expression of Dmpk 8 0.56 3.3 0.13 50.00
111 INT255125 Localization of Celf1 7 0.60 2.84 0.11 50.00
112 INT208918 Positive_regulation of Gene_expression of Nkx2-5 3 0.23 0.48 0.09 50.00
113 INT234193 Binding of Tpt1 5 0.31 1.5 0.09 50.00
114 INT272469 Negative_regulation of Gene_expression of Myod1 5 0.39 2.82 0.07 50.00
115 INT255129 Localization of Dmpk 5 0.65 3.1 0.07 50.00
116 INT311337 Positive_regulation of Uts2r 3 0.12 1.34 0.05 50.00
117 INT255119 Positive_regulation of Positive_regulation of Celf1 3 0.40 1.26 0.05 50.00
118 INT255136 Regulation of Gene_expression of Dmpk 2 0.39 0.56 0.05 50.00
119 INT272488 Positive_regulation of Cnbp 1 0.32 0.62 0.05 50.00
120 INT272482 Positive_regulation of Positive_regulation of Cnbp 1 0.32 0.63 0.05 50.00
121 INT311331 Negative_regulation of Binding of Celf1 1 0.34 0 0.04 50.00
122 INT311304 Phosphorylation of Eif2s2 1 0.22 0.06 0.03 50.00
123 INT272485 Regulation of Transcription of Dmpk 4 0.50 0.56 0.03 50.00
124 INT155564 Negative_regulation of Efemp2 4 0.43 0.53 0.03 50.00
125 INT235683 Regulation of Clcn1 4 0.21 1.49 0.03 50.00
126 INT211585 Negative_regulation of Gene_expression of Dmpk 5 0.47 1.63 0.03 50.00
127 INT255109 Binding of Hnrnph1 3 0.10 0.22 0.03 50.00
128 INT255097 Positive_regulation of Dmpk 4 0.61 2.06 0 50.00
129 INT311300 Gene_expression of Cnbp 1 0.45 0 0 50.00
130 INT236692 Phosphorylation of Cdk4 2 0.35 0.82 0 50.00
131 INT272466 Negative_regulation of Gene_expression of Rarg 1 0.05 0.37 0 50.00
132 INT311306 Regulation of Transcription of Celf1 1 0.22 0.29 0 50.00
133 INT272503 Gene_expression of MBNL3 1 0.19 0.19 0 50.00
134 INT272462 Transcription of Clcn1 4 0.63 1.21 0 50.00
135 INT311340 Positive_regulation of Transcription of Celf1 1 0.40 0.08 0 50.00
136 INT272480 Negative_regulation of Mef2a 2 0.40 0 0 50.00
137 INT272461 Negative_regulation of Gene_expression of Clcn1 2 0.52 0.82 0 50.00
138 INT311317 Positive_regulation of Negative_regulation of Efemp2 1 0.01 0 0 50.00
139 INT272465 Negative_regulation of Mbnl2 1 0.16 0.57 0 50.00
140 INT311345 Protein_catabolism of Efemp2 1 0.01 1.03 0 50.00
141 INT272478 Regulation of Phosphorylation of Celf1 2 0.49 0.36 0 50.00
142 INT311316 Protein_catabolism of Cnbp 1 0.59 0.48 0 50.00
143 INT311325 Negative_regulation of Binding of Cnbp 1 0.39 0.16 0 50.00
144 INT255108 Regulation of Gene_expression of Celf1 2 0.36 0.18 0 50.00
145 INT311334 Positive_regulation of Localization of Dmpk 1 0.38 0.76 0 50.00
146 INT311342 Positive_regulation of Negative_regulation of Mbnl1 1 0.30 0.26 0 50.00
147 INT272483 Localization of Itga3 1 0.01 0.2 0 50.00
148 INT296685 Negative_regulation of 20S 3 0.57 0.18 0 50.00
149 INT272477 Regulation of Mbnl2 1 0.10 0.2 0 50.00
150 INT311302 Positive_regulation of Protein_catabolism of Celf1 1 0.40 0.13 0 50.00
151 INT311322 Transcription of Celf1 1 0.55 0.38 0 50.00
152 INT311343 Negative_regulation of Cnbp 1 0.28 0.16 0 50.00
153 INT272474 Gene_expression of Rarg 1 0.08 0.36 0 50.00
154 INT272476 Negative_regulation of Transcription of Clcn1 3 0.43 1.05 0 50.00
155 INT311308 Binding of Cnbp 1 0.32 0.27 0 50.00
156 INT311313 Negative_regulation of Transcription of Dmpk 1 0.38 0 0 50.00
157 INT311327 Protein_catabolism of Celf1 1 0.71 0.13 0 50.00
158 INT190271 Negative_regulation of DICER1 2 0.04 0.24 0 50.00
159 INT311320 Regulation of Cnbp 1 0.30 0 0 50.00
160 INT311309 Protein_catabolism of Dmpk 1 0.67 0.62 0 50.00
161 INT272505 Negative_regulation of Gene_expression of CLCN1 1 0.27 0.1 0 50.00
162 INT272463 Phosphorylation of Ccnd3 1 0.07 0 0 50.00
163 INT311335 Negative_regulation of Localization of Dmpk 1 0.33 0 0 50.00
164 INT311303 Regulation of Protein_catabolism of Dmpk 1 0.21 0.07 0 50.00
165 INT255116 Positive_regulation of Positive_regulation of Dmpk 2 0.44 1.01 0 50.00
166 INT311329 Positive_regulation of Hdac1 1 0.19 0.14 0 50.00
167 INT311330 Negative_regulation of Positive_regulation of Celf1 1 0.35 0.85 0 50.00
168 INT274423 Positive_regulation of Gene_expression of Uts2r 3 0.09 0.58 0 50.00
169 INT272504 Positive_regulation of Gene_expression of DMPK 2 0.39 0.54 0 50.00
170 INT311315 Regulation of Positive_regulation of Celf1 1 0.22 0.29 0 50.00
171 INT311323 Binding of Ccnd3 1 0.07 0.07 0 50.00
172 INT311277 Regulation of Gene_expression of Clcn1 1 0.40 1 0 45.56
173 INT47434 Gene_expression of Tnnt2 14 0.60 10.4 1.37 42.64
174 INT311275 Regulation of Gene_expression of Tnnt2 2 0.34 1.33 0.1 42.64
175 INT182486 Gene_expression of Tnnt3 3 0.50 2.22 0 41.36
176 INT311278 Regulation of Gene_expression of Tnnt3 1 0.34 0.44 0 41.36
177 INT311290 Positive_regulation of CELF1 1 0.40 1.52 0.41 25.80
178 INT311292 Positive_regulation of Positive_regulation of DMPK 1 0.36 0.77 0.18 25.80
179 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
180 INT9429 Positive_regulation of Clcn1 18 0.58 10.03 2.07 5.00
181 INT19467 Localization of Clcn1 7 0.66 2.84 1.59 5.00
182 INT19466 Negative_regulation of Clcn1 6 0.52 3.39 1.22 5.00
183 INT121774 Binding of ACTA1 4 0.47 2.31 0.85 5.00
184 INT37012 Binding of Clcn1 11 0.33 4.83 0.7 5.00
185 INT155904 Localization of MMD 9 0.32 3.77 0.49 5.00
186 INT172303 Localization of NCOR2 6 0.06 1.3 0.3 5.00
187 INT289892 Gene_expression of SEPN1 3 0.42 1.17 0.13 5.00
188 INT311283 Positive_regulation of Phosphorylation of CELF1 1 0.26 0 0.05 5.00
189 INT311288 Positive_regulation of Positive_regulation of CELF1 1 0.26 0 0.05 5.00
190 INT311293 Phosphorylation of CELF1 1 0.36 0 0.05 5.00
191 INT311284 Negative_regulation of Gene_expression of DMPK 1 0.33 0.33 0 5.00
192 INT301729 Positive_regulation of Gene_expression of Myod1 2 0.24 1.53 0 5.00
193 INT311279 Positive_regulation of Gene_expression of Clcn1 1 0.44 0.06 0 5.00
194 INT311276 Negative_regulation of Gene_expression of Mbnl1 1 0.37 0.32 0 5.00
195 INT289876 Localization of Eng 3 0.44 0.59 0 5.00
196 INT311294 Negative_regulation of Gene_expression of CELF1 1 0.24 0.32 0 5.00
197 INT311280 Positive_regulation of Transcription of Clcn1 1 0.44 0.24 0 5.00
198 INT311285 Positive_regulation of Gene_expression of TRNAE1 1 0.49 0.05 0 5.00
199 INT289891 Localization of SEPN1 1 0.42 0.88 0 5.00
200 INT311286 Gene_expression of CELF1 1 0.38 0.48 0 5.00
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox