D:Nasal Obstruction

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Disease Term
Synonyms Nasal Obstructions, Obstruction Nasal, Obstructions Nasal
Documents 453
Hot Single Events 40
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Nasal Obstruction. They are ordered first by their relevance to Nasal Obstruction and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT86216 Hpd Regulation of NPC1 1 0.02 0.93 0.15 92.72
2 INT201535 Binding of NPC1 and XRCC1 1 0.26 1.6 0.05 48.04
3 INT271780 Zfp560 Negative_regulation of Cpox 1 0.00 0.62 0.86 5.00
4 INT211105 Binding of CRS and IGHE 1 0.02 3.63 0.66 5.00
5 INT193218 Binding of PTGER1 and PTGER2 3 0.12 2.31 0.66 5.00
6 INT164902 Binding of IL1RL1 and IL33 4 0.37 1.2 0.53 5.00
7 INT193219 Binding of LTC4S and CYSLTR2 2 0.28 2.2 0.44 5.00
8 INT193217 Binding of PTGER2 and PTGER3 2 0.10 1.31 0.43 5.00
9 INT241139 Ighg1 Positive_regulation of Hand2 1 0.06 0.65 0.32 5.00
10 INT241138 Ighg1 Positive_regulation of Hand1 1 0.06 0.64 0.32 5.00
11 INT319383 Binding of CCL18 and CCL22 1 0.19 1.07 0.25 5.00
12 INT193215 Binding of CYSLTR1 and CYSLTR2 2 0.09 1.7 0.21 5.00
13 INT193214 Binding of PTGER2 and PTGER4 2 0.08 2.51 0.18 5.00
14 INT319381 Binding of ST2 and IL33 1 0.13 1.01 0.18 5.00
15 INT193216 Binding of LTC4S and CYSLTR1 1 0.04 0.71 0.16 5.00
16 INT201543 Binding of NPC1 and RNASE1 1 0.07 1.33 0.08 5.00
17 INT196592 Binding of CFD and GHRH 1 0.02 1.88 0.07 5.00
18 INT319384 Binding of AR and SCGB2A2 1 0.01 1.36 0.04 5.00
19 INT319382 Binding of IL13 and CRISP3 1 0.09 0.87 0.03 5.00
20 INT201539 Binding of NPC1 and THY1 1 0.36 1.28 0 5.00
21 INT201534 RASSF1 Negative_regulation of ID2 1 0.33 1.41 0 5.00
22 INT201541 Binding of NPC1 and BRD7 1 0.35 1.59 0 5.00
23 INT201537 Binding of NPC1 and HHATL 1 0.16 1.43 0 5.00
24 INT201532 RASSF1 Regulation of NPC1 1 0.44 1.41 0 5.00
25 INT201540 GADD45G Negative_regulation of NPC1 1 0.32 1.7 0 5.00
26 INT201542 Positive_regulation of RASSF1 Negative_regulation of ID2 1 0.36 1.41 0 5.00
27 INT201536 RASSF1 Regulation of ID2 1 0.41 1.42 0 5.00
28 INT201533 RASSF1 Positive_regulation of Gene_expression of ID2 1 0.38 1.41 0 5.00
29 INT201538 Binding of BCL2 and NPC1 1 0.17 1.41 0 5.00
30 INT300631 Binding of TSC1 and TSC2 1 0.15 2.59 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Nasal Obstruction. They are ordered first by their pain relevance and then by number of times they were reported in Nasal Obstruction. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6 97.88
2 INT63839 Binding of CRS 31 0.41 34.05 4.7 97.88
3 INT18114 Gene_expression of NPC1 45 0.66 57.85 1.44 96.24
4 INT16996 Gene_expression of PRTN3 113 0.75 85.61 22.57 95.24
5 INT142637 Positive_regulation of Gene_expression of PRTN3 8 0.46 6.23 1.75 95.24
6 INT74507 Protein_catabolism of PRTN3 4 0.87 1.14 0.52 94.36
7 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 92.80
8 INT24278 Gene_expression of FUT4 33 0.75 26.7 4.29 92.80
9 INT193154 Regulation of CRAMP1L 5 0.28 3.04 0.34 91.88
10 INT477 Localization of Avp 813 0.81 131.58 300.4 91.32
11 INT76227 Binding of NPC1 30 0.41 32.31 4.05 91.16
12 INT62331 Gene_expression of TNFRSF8 26 0.72 17.75 2.08 90.88
13 INT1579 Gene_expression of PRL 279 0.78 119.2 55.41 90.80
14 INT29885 Gene_expression of GGH 13 0.67 12.77 0.96 90.80
15 INT168373 Gene_expression of Capns1 4 0.58 4.55 1.34 90.56
16 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7 87.44
17 INT1125 Positive_regulation of IGHG3 130 0.69 112.07 13.18 87.44
18 INT36263 Positive_regulation of CEL 53 0.69 34.88 12.87 87.44
19 INT56924 Binding of CRTAC1 3 0.28 2.82 1.03 87.00
20 INT4860 Positive_regulation of CALCA 148 0.00 73.35 97.61 86.96
21 INT1734 Negative_regulation of HSD11B1 116 0.57 125.13 10.52 86.40
22 INT96234 Localization of Il13 11 0.62 10.94 5.48 86.24
23 INT5841 Gene_expression of Vim 181 0.72 138.54 16.33 86.16
24 INT2451 Positive_regulation of Avp 355 0.70 102.66 147.69 85.44
25 INT12324 Positive_regulation of PRTN3 26 0.70 18.82 4.55 85.00
26 INT69157 Gene_expression of IL5 127 0.77 102.58 26.81 84.60
27 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 84.60
28 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 84.60
29 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 84.60
30 INT60694 Gene_expression of Il10 567 0.78 369.48 143.69 84.60
31 INT20374 Gene_expression of Il4 515 0.76 306.15 114.12 84.60
32 INT4880 Regulation of MME 17 0.61 7.78 8.2 84.16
33 INT11062 Positive_regulation of MME 24 0.63 14.37 5.26 84.16
34 INT236711 Gene_expression of Bcl6 15 0.30 12.98 0.58 83.28
35 INT11380 Negative_regulation of IL1B 215 0.59 125.62 72.35 83.04
36 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 83.04
37 INT116498 Negative_regulation of Negative_regulation of IL1B 7 0.41 3.08 1.7 83.04
38 INT36121 Regulation of CLPP 4 0.59 0.78 1.39 82.56
39 INT16631 Negative_regulation of APC 46 0.57 30.53 7.11 81.88
40 INT16997 Binding of PRTN3 34 0.48 33.44 6.45 81.04
41 INT36798 Gene_expression of Mki67 178 0.77 132 8.24 79.84
42 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 79.12
43 INT5650 Gene_expression of Mpo 117 0.77 80.27 26.42 78.92
44 INT7133 Negative_regulation of MME 85 0.59 29.22 33.1 78.00
45 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 77.60
46 INT315360 Negative_regulation of Negative_regulation of ELN 1 0.02 0.94 0.06 77.44
47 INT8775 Binding of IGHE 167 0.48 102.61 23.54 77.28
48 INT11560 Positive_regulation of CASP3 236 0.70 184.33 39.38 76.32
49 INT15812 Localization of CALCB 10 0.30 8.77 6.36 74.80
50 INT26282 Negative_regulation of ELN 9 0.51 6.37 3.76 73.76
51 INT156 Negative_regulation of Prl 542 0.59 131.97 192.24 73.36
52 INT76690 Negative_regulation of Gene_expression of Vim 1 0.39 1.4 0.42 72.88
53 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 71.52
54 INT15238 Positive_regulation of NPY 24 0.67 11.86 11.26 71.44
55 INT9233 Negative_regulation of Gene_expression of IL1B 114 0.59 56.99 41.82 68.48
56 INT5008 Localization of Calca 204 0.81 80.35 125.16 68.32
57 INT55114 Gene_expression of CRS 42 0.58 26.86 4.69 68.32
58 INT2540 Negative_regulation of Calca 538 0.59 172.11 384.38 66.44
59 INT9657 Positive_regulation of Gene_expression of Il6 237 0.70 180.45 63.6 65.76
60 INT15752 Positive_regulation of Ema 15 0.40 14.57 2.34 63.68
61 INT106359 Regulation of Plau 7 0.45 3.51 1.5 63.44
62 INT3988 Positive_regulation of Gene_expression of IGHE 98 0.68 91.46 9.61 63.20
63 INT6107 Localization of Npy 180 0.81 26.76 81.67 62.16
64 INT55583 Localization of IFNA1 135 0.78 85.07 24.13 62.00
65 INT22875 Regulation of CRS 16 0.39 14.33 2.69 61.72
66 INT29950 Negative_regulation of GGH 3 0.25 2.18 0.29 61.56
67 INT956 Negative_regulation of PRL 94 0.59 42.72 23.01 61.28
68 INT7336 Positive_regulation of VIP 60 0.70 24.2 19.62 61.28
69 INT48244 Gene_expression of Il4 172 0.76 132.38 73.42 60.36
70 INT75434 Gene_expression of Il13 27 0.52 26.19 15.4 60.36
71 INT193156 Gene_expression of CRAMP1L 17 0.42 10.96 0.18 60.08
72 INT8836 Positive_regulation of SFTPA1 36 0.47 28.37 23.59 60.08
73 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 59.44
74 INT99091 Regulation of AR 70 0.45 31.68 5.05 59.36
75 INT97973 Positive_regulation of XRCC1 24 0.40 30.95 2.26 57.80
76 INT84018 Gene_expression of RNASE3 15 0.65 8.27 2.12 57.80
77 INT74021 Regulation of XRCC1 15 0.44 16.91 0.88 57.80
78 INT69160 Positive_regulation of IL5 41 0.65 36.04 7.75 56.04
79 INT84020 Positive_regulation of RNASE3 17 0.47 11.92 2.92 56.04
80 INT49439 Gene_expression of Cpox 508 0.73 326.97 130.17 55.28
81 INT27387 Binding of Aecp 4 0.34 5.09 1 54.32
82 INT19330 Binding of HLA-A 99 0.48 76.26 22.85 50.32
83 INT425 Localization of PRL 455 0.81 189.64 144.8 49.68
84 INT19084 Negative_regulation of NRG1 5 0.42 4.9 0.96 49.20
85 INT12265 Positive_regulation of IgG 168 0.63 104.89 19.76 48.52
86 INT61018 Positive_regulation of Pax1 2 0.48 0.9 0.08 48.52
87 INT1261 Localization of Adh1 63 0.81 19.36 16.09 45.60
88 INT254038 Transcription of AMH 1 0.58 0.93 0 45.48
89 INT254039 Positive_regulation of Transcription of AMH 1 0.56 0.47 0 45.48
90 INT96951 Positive_regulation of Gene_expression of Gclc 5 0.34 1.45 0.16 42.48
91 INT96952 Gene_expression of Gclc 7 0.38 2.08 0.28 41.68
92 INT121347 Binding of GNAS 8 0.13 3.99 1.47 41.60
93 INT73731 Binding of RAPH1 9 0.33 14.58 0.5 41.40
94 INT148562 Positive_regulation of GNAS 13 0.16 5.31 1.32 40.48
95 INT1273 Gene_expression of Avp 356 0.78 90.56 138.7 39.60
96 INT254037 Regulation of Transcription of AMH 1 0.50 0.45 0 39.52
97 INT2971 Regulation of IGHE 42 0.61 28.81 7.87 37.04
98 INT125821 Regulation of Positive_regulation of IGHE 6 0.40 5.38 0.53 37.04
99 INT27935 Binding of Vim 21 0.36 15.65 2.61 35.96
100 INT88070 Binding of Ema 7 0.18 7.39 0.31 35.96
101 INT35164 Negative_regulation of IGHE 96 0.58 76.3 9.74 34.64
102 INT701 Localization of IGHE 87 0.80 40.5 10.62 33.72
103 INT14 Regulation of LDHA 22 0.57 15.26 2.14 32.56
104 INT254040 Regulation of FGF9 2 0.57 1.04 0.21 32.56
105 INT309328 Positive_regulation of Klk1b4 1 0.49 0.67 0.65 32.40
106 INT211107 Regulation of Regulation of CRS 1 0.32 0.99 0.21 31.12
107 INT33358 Gene_expression of Cysltr1 46 0.62 24.18 13.36 29.20
108 INT145147 Negative_regulation of Gene_expression of TP63 4 0.42 2.91 0.15 27.76
109 INT111476 Gene_expression of TP63 88 0.76 61.08 11.64 27.40
110 INT20622 Gene_expression of LDHA 107 0.76 77.97 16.3 25.92
111 INT20629 Negative_regulation of Gene_expression of LDHA 4 0.41 1.78 0.34 25.92
112 INT12339 Localization of IL8 437 0.81 251.87 117.39 25.00
113 INT124407 Gene_expression of SSTR1 4 0.55 5.55 1.41 23.84
114 INT106952 Positive_regulation of NPC1 23 0.43 22.9 0.94 21.80
115 INT222994 Positive_regulation of Localization of COL7A1 2 0.38 0.78 0.03 20.60
116 INT2144 Localization of COL7A1 36 0.74 20.92 4.67 20.36
117 INT50387 Negative_regulation of AR 67 0.45 26.31 6.61 14.56
118 INT6488 Gene_expression of Tnf 484 0.78 339.61 191.58 12.72
119 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 10.36
120 INT18357 Gene_expression of TRPV1 825 0.78 307.11 382.81 5.00
121 INT6580 Negative_regulation of Ptgs1 929 0.59 381.53 376.26 5.00
122 INT49750 Negative_regulation of CPOX 735 0.58 360.06 274.19 5.00
123 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
124 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
125 INT626 Localization of CALCA 289 0.81 125.39 221.15 5.00
126 INT50670 Gene_expression of CPOX 763 0.76 442.13 195.02 5.00
127 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
128 INT49441 Negative_regulation of Cpox 494 0.59 303.22 177.46 5.00
129 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 5.00
130 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 5.00
131 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
132 INT2867 Gene_expression of CALCA 247 0.78 78.78 138.47 5.00
133 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 5.00
134 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 5.00
135 INT1760 Gene_expression of PTGER2 524 0.57 226.94 96.4 5.00
136 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 5.00
137 INT86024 Gene_expression of PPARA 736 0.78 497.93 91.14 5.00
138 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27 5.00
139 INT82448 Gene_expression of S100a8 246 0.77 236.72 84.02 5.00
140 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 5.00
141 INT749 Gene_expression of HLA-B 341 0.75 224.12 77.37 5.00
142 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92 5.00
143 INT10837 Positive_regulation of Gene_expression of IL8 294 0.70 190.08 70.34 5.00
144 INT170332 Gene_expression of IFN1@ 477 0.75 275.21 69.65 5.00
145 INT6849 Localization of IL1B 229 0.81 112.56 69.63 5.00
146 INT9489 Gene_expression of SFTPA1 112 0.66 55.38 66.45 5.00
147 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 5.00
148 INT67614 Positive_regulation of PPARA 438 0.68 293.28 63.61 5.00
149 INT67981 Positive_regulation of CCL2 165 0.70 136.84 61.85 5.00
150 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87 5.00
151 INT73048 Gene_expression of MMP9 268 0.77 159.75 57.81 5.00
152 INT46637 Gene_expression of CXCL10 172 0.78 121.94 57.74 5.00
153 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 5.00
154 INT4241 Regulation of CALCA 87 0.62 28.19 55.29 5.00
155 INT20375 Gene_expression of Hand1 213 0.60 148.51 54.53 5.00
156 INT117223 Gene_expression of TLR4 348 0.78 206.18 54.42 5.00
157 INT8490 Negative_regulation of CALCA 87 0.59 29.73 51.34 5.00
158 INT12345 Gene_expression of Il2 142 0.78 59.17 51.21 5.00
159 INT20382 Gene_expression of Hand2 211 0.66 142.26 51.05 5.00
160 INT19775 Localization of Il1 183 0.78 145.5 50.91 5.00
161 INT71786 Phosphorylation of MAPK1 256 0.82 110.09 46.17 5.00
162 INT25383 Gene_expression of Csf2 222 0.76 152.93 43.32 5.00
163 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 5.00
164 INT28265 Positive_regulation of Calca 62 0.70 29.1 41.17 5.00
165 INT89661 Gene_expression of Hrec 102 0.21 69.91 39.57 5.00
166 INT8835 Localization of SFTPA1 65 0.68 32.81 38.65 5.00
167 INT11439 Positive_regulation of Csf2 105 0.69 62.63 37.77 5.00
168 INT48222 Positive_regulation of Localization of IL8 123 0.59 78.04 37.2 5.00
169 INT53577 Negative_regulation of Localization of TNF 110 0.59 59.28 35.23 5.00
170 INT20380 Gene_expression of Il5 172 0.78 104.75 34.78 5.00
171 INT103094 Binding of PPARA 308 0.47 177.26 34.75 5.00
172 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19 5.00
173 INT16960 Gene_expression of Crp 166 0.76 116.21 34.07 5.00
174 INT67039 Positive_regulation of Cpox 144 0.65 98.4 33.77 5.00
175 INT2732 Gene_expression of VIP 74 0.78 24.57 33.72 5.00
176 INT65698 Localization of CCL2 118 0.81 77.54 32.69 5.00
177 INT73498 Gene_expression of IL13 117 0.44 83.85 32.26 5.00
178 INT22939 Gene_expression of Csf2 164 0.78 85.1 32.22 5.00
179 INT51685 Gene_expression of LTB4R 87 0.58 68.69 31.72 5.00
180 INT48693 Regulation of VEGFA 268 0.62 191.88 31.52 5.00
181 INT129207 Gene_expression of Cxcl1 114 0.75 68.54 30.82 5.00
182 INT5117 Negative_regulation of Gene_expression of IL2 118 0.59 52.33 29.96 5.00
183 INT9053 Negative_regulation of ALOX5 97 0.58 40.34 29.94 5.00
184 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 5.00
185 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 5.00
186 INT23463 Positive_regulation of Gene_expression of CALCA 47 0.70 18.14 28.76 5.00
187 INT9199 Positive_regulation of CEBPZ 111 0.67 30.99 28.45 5.00
188 INT14690 Localization of CSF2 124 0.80 85.17 27.26 5.00
189 INT1765 Positive_regulation of Gene_expression of PTGER2 140 0.51 68.68 27 5.00
190 INT17739 Gene_expression of S100B 226 0.78 132.7 26.4 5.00
191 INT1761 Positive_regulation of PTGER2 135 0.49 90.17 26.26 5.00
192 INT14884 Positive_regulation of Gene_expression of SFTPA1 32 0.25 20.37 26.09 5.00
193 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 5.00
194 INT12124 Gene_expression of MAPK1 141 0.75 82.4 25.58 5.00
195 INT9886 Gene_expression of Ptgs1 92 0.77 40.66 25.31 5.00
196 INT15458 Gene_expression of NPY 50 0.76 22.67 23.03 5.00
197 INT3330 Gene_expression of AGT 149 0.76 98.65 22.73 5.00
198 INT6868 Gene_expression of GFAP 136 0.78 84.65 22.7 5.00
199 INT91891 Gene_expression of Kit 268 0.78 158.89 22.67 5.00
200 INT7383 Localization of VIP 53 0.81 17.7 22.65 5.00
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