D:Neonatal Necrotizing Enterocolitis

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Disease Term
Synonyms Enterocolitis Necrotizing, NECROTISING ENTEROCOLITIS, NECROTISING ENTEROCOLITIS IN NEWBORN, Necrotising Enterocolitis In The Fetus, NECROTISING ENTEROCOLITIS IN THE FOETUS, NECROTISING ENTEROCOLITIS OF NEWBORN, Necrotising Enterocolitis Of The Fetus, Necrotising Enterocolitis Of The Foetus, Necrotizing Enterocolitis, NECROTIZING ENTEROCOLITIS IN NEWBORN, Necrotizing Enterocolitis In The Fetus
Documents 186
Hot Single Events 38
Hot Interactions 11

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Neonatal Necrotizing Enterocolitis. They are ordered first by their relevance to Neonatal Necrotizing Enterocolitis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT337310 PTAFR Regulation of Gene_expression of TLR4 1 0.24 0.8 0.18 99.64
2 INT337304 PTAFR Positive_regulation of Gene_expression of TLR4 1 0.62 1.99 0.36 99.36
3 INT337293 PTAFR Positive_regulation of Positive_regulation of TLR4 1 0.62 1.43 0.28 93.72
4 INT180984 IRF6 Positive_regulation of Localization of IL8 7 0.11 2.13 3.47 91.36
5 INT272146 PTAFR Positive_regulation of Localization of IL8 3 0.38 0.28 0.59 87.44
6 INT337309 PTAFR Regulation of Localization of IRF6 1 0.06 0.89 0 86.84
7 INT337291 TLR4 Regulation of Localization of IRF6 1 0.05 0.47 0 86.16
8 INT337302 PLA2G6 Regulation of Gene_expression of PTAFR 1 0.09 1.18 0.07 85.80
9 INT37217 Binding of SMN1 and Mofp1 1 0.00 1.39 0.26 85.68
10 INT337306 TLR4 Regulation of Localization of IL8 1 0.06 0.47 0 85.68
11 INT337305 PTAFR Regulation of Localization of IL8 1 0.06 0.47 0 85.68
12 INT337295 PTAFR Positive_regulation of Localization of STAT3 1 0.43 0.85 0.22 79.64
13 INT337303 Positive_regulation of PTAFR Positive_regulation of EDNRA 1 0.04 1.21 0.06 77.24
14 INT337297 PTAFR Positive_regulation of EDNRA 1 0.04 1.2 0.06 77.24
15 INT337292 STAT3 Negative_regulation of Gene_expression of PTAFR 1 0.27 0.3 0 73.84
16 INT337294 IRF6 Positive_regulation of Gene_expression of TLR4 1 0.06 0.16 0 73.28
17 INT276964 Binding of Tlr1 and Tlr2 11 0.24 4.22 0.89 5.00
18 INT276988 Binding of Tlr6 and Tlr2 11 0.26 4.89 0.79 5.00
19 INT312803 F2 Positive_regulation of NPEPPS 1 0.01 1.32 0.32 5.00
20 INT312802 F2 Positive_regulation of Binding of NPEPPS 1 0.01 1.33 0.32 5.00
21 INT308084 Binding of HSPG2 and OXT 1 0.04 0.25 0.23 5.00
22 INT265919 Binding of PLEK and Adp 1 0.01 0.38 0.11 5.00
23 INT337308 PTAFR Regulation of TLR4 1 0.24 0.1 0.1 5.00
24 INT329798 Binding of MYD88 and TICAM1 2 0.01 0.24 0.1 5.00
25 INT337290 PTAFR Positive_regulation of Phosphorylation of STAT3 1 0.43 0.07 0.07 5.00
26 INT298733 INS Regulation of ACSBG1 1 0.00 0.97 0.05 5.00
27 INT298734 USE1 Regulation of ACSBG1 1 0.00 0.97 0.05 5.00
28 INT181168 Binding of CD79A and TAPBP 1 0.10 0.7 0.04 5.00
29 INT350802 Binding of MYD88 and TLR3 1 0.01 0 0.04 5.00
30 INT227333 Il2 Positive_regulation of Hmox1 1 0.05 0.93 0.04 5.00
31 INT350800 Binding of TLR3 and TICAM1 1 0.01 0 0.04 5.00
32 INT350792 Binding of Hspd1 and Lsr1 1 0.00 0.25 0 5.00
33 INT337300 STAT3 Regulation of TLR4 1 0.15 0 0 5.00
34 INT181169 TAPBP Negative_regulation of MALT1 1 0.00 0.48 0 5.00
35 INT181167 TAPBP Negative_regulation of CD79A 1 0.11 0.48 0 5.00
36 INT337301 STAT3 Negative_regulation of Gene_expression of TLR4 1 0.33 0 0 5.00
37 INT181165 TAPBP Regulation of Gene_expression of CD79A 1 0.07 0.35 0 5.00
38 INT337299 PTAFR Regulation of STAT3 1 0.28 0 0 5.00
39 INT337307 Positive_regulation of PTAFR Positive_regulation of Localization of STAT3 1 0.25 0 0 5.00
40 INT192618 Atrx Regulation of Gene_expression of Hba-a1 1 0.08 0.45 0 5.00
41 INT350796 Binding of CEBPB and Hspd1 1 0.00 0.25 0 5.00
42 INT337285 STAT3 Regulation of STAT3 Regulation of TLR4 1 0.10 0 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Neonatal Necrotizing Enterocolitis. They are ordered first by their pain relevance and then by number of times they were reported in Neonatal Necrotizing Enterocolitis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT88032 Negative_regulation of PCSK1 4 0.32 1.27 0.92 100.00
2 INT134651 Binding of TLR4 89 0.48 66.96 23.19 100.00
3 INT13303 Positive_regulation of PTAFR 40 0.69 16.27 11.56 99.98
4 INT5160 Localization of PTAFR 61 0.80 42.6 19.16 99.54
5 INT117223 Gene_expression of TLR4 348 0.78 206.18 54.42 99.48
6 INT117222 Positive_regulation of Gene_expression of TLR4 80 0.70 51.6 12.9 99.28
7 INT30526 Negative_regulation of PTAFR 15 0.58 8.15 8.19 99.16
8 INT145650 Localization of PLA2G6 15 0.76 8.87 2.06 99.06
9 INT26312 Positive_regulation of PLA2G6 26 0.70 7.41 3.2 99.06
10 INT10896 Regulation of PTAFR 16 0.61 4.22 4.5 98.76
11 INT145768 Regulation of TLR4 19 0.45 8.31 2.96 98.76
12 INT337320 Negative_regulation of Protein_catabolism of PTAFR 1 0.40 1.66 0.22 98.72
13 INT142594 Gene_expression of Tlr2 165 0.78 139.73 22.26 98.48
14 INT142596 Positive_regulation of Gene_expression of Tlr2 42 0.69 38.41 6.67 98.48
15 INT10507 Positive_regulation of Gene_expression of PTAFR 15 0.61 10.24 6.61 98.08
16 INT10506 Gene_expression of PTAFR 86 0.76 37.57 28.58 97.40
17 INT51680 Protein_catabolism of PTAFR 7 0.64 3.69 2.59 96.48
18 INT13302 Binding of PTAFR 20 0.48 7.03 3.7 96.32
19 INT133028 Gene_expression of TLR2 209 0.73 131.92 36.17 94.88
20 INT92137 Binding of GALT 4 0.36 2.99 0.92 94.80
21 INT117220 Positive_regulation of TLR4 64 0.69 53.61 17.33 93.72
22 INT143159 Regulation of Gene_expression of TLR4 28 0.62 15.08 3.54 93.60
23 INT48222 Positive_regulation of Localization of IL8 123 0.59 78.04 37.2 91.72
24 INT64499 Positive_regulation of IRF6 123 0.49 52.73 27.51 91.72
25 INT9884 Localization of CD79A 41 0.78 21.75 3.06 91.68
26 INT97798 Localization of IRF6 86 0.73 33.27 20.94 91.36
27 INT12339 Localization of IL8 437 0.81 251.87 117.39 90.88
28 INT40478 Negative_regulation of NCOR2 23 0.48 12.77 14.56 89.16
29 INT49750 Negative_regulation of CPOX 735 0.58 360.06 274.19 89.04
30 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6 89.04
31 INT138779 Positive_regulation of Localization of IRF6 25 0.45 11.51 4.51 86.16
32 INT78774 Gene_expression of PLA2G6 15 0.61 8.39 1.56 85.80
33 INT51683 Regulation of Gene_expression of PTAFR 11 0.60 5.06 2.59 85.44
34 INT188584 Positive_regulation of Positive_regulation of TLR4 8 0.65 5.98 1.64 84.40
35 INT181177 Gene_expression of CYLD 5 0.69 24.96 0.89 84.32
36 INT55469 Positive_regulation of Positive_regulation of PTAFR 9 0.47 3 2.17 83.76
37 INT337321 Gene_expression of Ly96 1 0.03 1.94 0.45 81.48
38 INT142593 Positive_regulation of Tlr2 85 0.70 75.9 13.62 80.40
39 INT165617 Localization of STAT3 28 0.78 9.04 1.72 79.12
40 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 78.80
41 INT122606 Positive_regulation of Ly96 2 0.02 1.59 0.6 78.44
42 INT70905 Positive_regulation of EDNRA 49 0.67 24.33 11.79 77.24
43 INT238901 Phosphorylation of PTAFR 2 0.58 1.54 0.3 76.72
44 INT337313 Positive_regulation of Phosphorylation of PTAFR 1 0.43 0.32 0 76.72
45 INT36947 Gene_expression of PNLIP 13 0.45 11.04 1.23 76.72
46 INT91370 Phosphorylation of STAT3 123 0.82 49.25 8.42 76.24
47 INT91519 Negative_regulation of Positive_regulation of PTAFR 4 0.41 1.52 2.15 76.04
48 INT37216 Binding of SMN1 11 0.36 6.66 1.86 75.12
49 INT37215 Positive_regulation of SMN1 18 0.45 8.99 4.87 75.00
50 INT11699 Binding of HLA-E 85 0.47 52.51 13.41 73.68
51 INT121788 Localization of BCS1L 11 0.73 10.16 1.14 73.28
52 INT149197 Negative_regulation of NFKB2 14 0.25 10.55 4.46 73.08
53 INT91371 Negative_regulation of STAT3 34 0.59 25 4.08 73.08
54 INT143158 Negative_regulation of Gene_expression of TLR4 31 0.56 20.62 5.69 71.64
55 INT42032 Localization of PNLIP 4 0.14 3.44 0.41 71.32
56 INT1708 Gene_expression of OXTR 56 0.78 6.92 10.69 69.72
57 INT621 Positive_regulation of SERPINH1 19 0.57 21.52 8.44 66.48
58 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68 63.60
59 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 63.60
60 INT48895 Gene_expression of Il10 333 0.78 221.2 138.52 63.60
61 INT48244 Gene_expression of Il4 172 0.76 132.38 73.42 63.60
62 INT75434 Gene_expression of Il13 27 0.52 26.19 15.4 63.60
63 INT63401 Gene_expression of Il5 33 0.72 18.66 8.2 63.60
64 INT151795 Gene_expression of Il16 5 0.60 4.83 3.94 63.60
65 INT76708 Gene_expression of Il3 5 0.30 5.47 1.43 63.60
66 INT65659 Positive_regulation of STAT3 132 0.70 69.56 15.95 62.88
67 INT22045 Gene_expression of IRF6 158 0.75 58.07 27.81 61.64
68 INT337315 Positive_regulation of Localization of SLC15A1 1 0.01 0.19 0 60.12
69 INT337319 Localization of SLC15A1 1 0.01 0.19 0 59.52
70 INT55343 Localization of Ros1 39 0.60 34.51 12.5 57.92
71 INT337317 Positive_regulation of Localization of PTAFR 2 0.51 3.88 2.5 57.36
72 INT1888 Protein_catabolism of F13A1 97 0.99 63.48 14.82 56.96
73 INT3881 Positive_regulation of Protein_catabolism of F13A1 21 0.41 20 3.28 56.96
74 INT69523 Regulation of Localization of PTAFR 2 0.45 0.32 0.12 56.40
75 INT10139 Positive_regulation of F13A1 64 0.56 44.75 9.69 56.00
76 INT81049 Positive_regulation of CASP1 44 0.67 19.97 5.69 55.72
77 INT91658 Localization of CASP1 5 0.77 0.89 1.04 55.16
78 INT124322 Negative_regulation of PNLIP 11 0.31 6.53 1.88 54.00
79 INT244368 Binding of CENPI 1 0.04 0.65 0.25 52.40
80 INT1080 Negative_regulation of Ache 343 0.59 108.51 72.4 49.04
81 INT263019 Gene_expression of DEFA6 4 0.25 4.14 1.17 47.64
82 INT125009 Gene_expression of HDAC5 3 0.44 0.22 0.09 46.92
83 INT346900 Gene_expression of HDAC6 1 0.13 0.17 0.06 46.60
84 INT186800 Positive_regulation of Binding of TLR4 2 0.47 1.31 0.67 43.40
85 INT201474 Regulation of Acta1 3 0.18 1.98 0 39.40
86 INT350779 Positive_regulation of Positive_regulation of TLR9 1 0.08 0.8 0.15 39.12
87 INT204529 Positive_regulation of TLR9 18 0.62 15.62 3.99 38.80
88 INT190367 Gene_expression of Defa1 10 0.75 8.92 1.5 37.88
89 INT162792 Gene_expression of NOD1 19 0.71 6.11 2.71 37.84
90 INT46121 Negative_regulation of SERPINH1 14 0.38 10.84 4.41 36.48
91 INT103909 Gene_expression of NOD2 37 0.77 21.9 7.36 35.64
92 INT118871 Negative_regulation of JAK2 15 0.57 11.4 2.16 35.44
93 INT21900 Gene_expression of Mthfd1 150 0.75 69.47 27.03 35.32
94 INT117219 Positive_regulation of NOD2 9 0.69 4.66 1.31 33.04
95 INT244161 Positive_regulation of NOD1 4 0.64 1.83 0.62 33.04
96 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 32.80
97 INT130176 Positive_regulation of Gene_expression of CRP 125 0.66 137.06 25.9 32.80
98 INT273472 Regulation of Gene_expression of BCS1L 1 0.32 1.89 0 32.68
99 INT157846 Gene_expression of BCS1L 13 0.50 15.89 0.83 32.08
100 INT82448 Gene_expression of S100a8 246 0.77 236.72 84.02 31.56
101 INT144766 Binding of BCS1L 11 0.32 8.2 0.13 28.44
102 INT67822 Binding of SERPINH1 17 0.36 19.05 7.24 25.44
103 INT256598 Gene_expression of DEFB103A 8 0.65 5.06 1.49 25.32
104 INT11325 Gene_expression of HLA-E 209 0.76 98.05 33.72 25.24
105 INT209962 Binding of RDBP 4 0.11 2.93 1.27 24.16
106 INT247099 Positive_regulation of PTBP1 7 0.50 9.21 0.16 23.84
107 INT182137 Gene_expression of TLR9 137 0.78 48.48 9.05 22.00
108 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 18.96
109 INT294787 Localization of TLR9 2 0.67 2.35 0.75 16.80
110 INT2120 Gene_expression of CD79A 159 0.78 111.69 17.16 16.16
111 INT1126 Negative_regulation of CD79A 46 0.59 31.07 6 15.60
112 INT6957 Positive_regulation of OXTR 38 0.70 6.55 7.81 10.32
113 INT204781 Positive_regulation of Nod2 6 0.45 2.79 0.46 10.00
114 INT207892 Binding of Tlr9 35 0.46 26.66 6.61 9.76
115 INT204524 Binding of TLR9 17 0.43 11.69 2.76 9.76
116 INT181178 Positive_regulation of NAALADL1 1 0.01 0 0.03 8.48
117 INT2040 Positive_regulation of CYP2B6 95 0.69 34.3 25.6 8.04
118 INT8766 Positive_regulation of Positive_regulation of CYP2B6 5 0.49 3.41 1.97 8.04
119 INT337311 Negative_regulation of Positive_regulation of TLR4 1 0.35 0 0 7.52
120 INT66754 Negative_regulation of Transcription of Tnf 11 0.43 8.43 3.93 6.24
121 INT66755 Transcription of Tnf 45 0.72 37.1 19.11 5.24
122 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
123 INT443 Localization of POMC 1020 0.81 284.52 443.17 5.00
124 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
125 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
126 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
127 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
128 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
129 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
130 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
131 INT11313 Positive_regulation of Il6 526 0.70 331.27 201.59 5.00
132 INT6354 Localization of Gabrg1 321 0.74 41.41 186.74 5.00
133 INT60694 Gene_expression of Il10 567 0.78 369.48 143.69 5.00
134 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 5.00
135 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 5.00
136 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51 5.00
137 INT118381 Gene_expression of Il17a 405 0.76 306.97 112.06 5.00
138 INT27096 Positive_regulation of Nfkb1 325 0.70 195.11 109.06 5.00
139 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 5.00
140 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
141 INT12082 Localization of IL6 365 0.81 241.78 105.78 5.00
142 INT1760 Gene_expression of PTGER2 524 0.57 226.94 96.4 5.00
143 INT214 Localization of AVP 370 0.81 208.51 91.09 5.00
144 INT56291 Gene_expression of Ros1 503 0.63 274.12 81.5 5.00
145 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 5.00
146 INT6849 Localization of IL1B 229 0.81 112.56 69.63 5.00
147 INT10706 Regulation of Il6 150 0.62 93.23 62.34 5.00
148 INT39153 Positive_regulation of PTGS2 182 0.70 96.16 60.6 5.00
149 INT6623 Gene_expression of NA 231 0.78 45.78 59.36 5.00
150 INT3920 Localization of Ldha 241 0.81 83.08 58.72 5.00
151 INT48891 Positive_regulation of Il10 143 0.70 101.42 56.72 5.00
152 INT52692 Gene_expression of Ptgs2 160 0.78 85.06 55.73 5.00
153 INT251 Regulation of INS 398 0.62 232.47 55.04 5.00
154 INT49993 Positive_regulation of Gene_expression of Il6 149 0.70 88.07 53.78 5.00
155 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 5.00
156 INT937 Positive_regulation of Oxt 195 0.70 37.82 49.3 5.00
157 INT374 Positive_regulation of Ldha 212 0.70 107.08 47.43 5.00
158 INT5307 Regulation of Tnf 87 0.62 78.71 43.4 5.00
159 INT60695 Positive_regulation of Gene_expression of Il10 154 0.70 120.28 43.07 5.00
160 INT613 Gene_expression of Alb 268 0.78 149.84 42.78 5.00
161 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 5.00
162 INT4004 Gene_expression of IGHG3 321 0.71 221.03 42.33 5.00
163 INT957 Positive_regulation of GHRH 136 0.70 36.84 40.52 5.00
164 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 5.00
165 INT55135 Positive_regulation of Gene_expression of PTGS2 137 0.70 80.32 38.46 5.00
166 INT63349 Gene_expression of PECAM1 199 0.75 166.03 36.76 5.00
167 INT9239 Regulation of Gene_expression of IL6 106 0.61 75.24 36.53 5.00
168 INT927 Gene_expression of Oxt 184 0.78 44.71 35.79 5.00
169 INT48896 Positive_regulation of Gene_expression of Il10 73 0.70 43.14 35.5 5.00
170 INT9658 Negative_regulation of Gene_expression of Il6 110 0.59 66.29 32.58 5.00
171 INT73982 Gene_expression of Hmox1 141 0.78 119.43 32.17 5.00
172 INT90792 Localization of Il10 144 0.80 87.88 30.03 5.00
173 INT32165 Binding of CALM1 92 0.48 24.19 29.57 5.00
174 INT651 Positive_regulation of PTGS1 93 0.69 37.27 29.18 5.00
175 INT87212 Negative_regulation of Positive_regulation of Nfkb1 74 0.57 38.21 28.31 5.00
176 INT1765 Positive_regulation of Gene_expression of PTGER2 140 0.51 68.68 27 5.00
177 INT52801 Regulation of Gene_expression of Tnf 55 0.62 48.74 26.59 5.00
178 INT50490 Regulation of PTGS2 80 0.48 39.51 25.85 5.00
179 INT70048 Positive_regulation of Gene_expression of IL10 90 0.55 71.34 25.66 5.00
180 INT151758 Gene_expression of PYCARD 91 0.63 14.54 24.27 5.00
181 INT22708 Gene_expression of MUC1 297 0.78 232.71 24.19 5.00
182 INT4369 Gene_expression of Ldha 157 0.76 88.12 22.45 5.00
183 INT48692 Binding of VEGFA 345 0.48 210.3 21.31 5.00
184 INT69304 Negative_regulation of Il10 47 0.59 36.88 19.79 5.00
185 INT6993 Negative_regulation of Mpo 72 0.59 61.83 19.51 5.00
186 INT74286 Regulation of Il10 42 0.44 28.06 19.44 5.00
187 INT18311 Positive_regulation of CD8A 145 0.69 113.48 19.44 5.00
188 INT1278 Negative_regulation of Ldha 93 0.59 37.66 19.36 5.00
189 INT5398 Positive_regulation of ALPP 178 0.70 110.52 19.18 5.00
190 INT10565 Gene_expression of MRXS5 94 0.53 37.35 19.08 5.00
191 INT20260 Positive_regulation of Chkb 41 0.64 21.48 18.53 5.00
192 INT116978 Gene_expression of CCR6 53 0.78 56 17.73 5.00
193 INT80223 Positive_regulation of Hmox1 128 0.68 77.71 17.64 5.00
194 INT615 Regulation of Alb 66 0.62 33.43 15.33 5.00
195 INT49532 Regulation of Gene_expression of Il6 43 0.61 25.8 14.99 5.00
196 INT80228 Positive_regulation of Gene_expression of Hmox1 68 0.70 62.88 14.01 5.00
197 INT161515 Positive_regulation of Gene_expression of Il17a 50 0.64 41.52 13.82 5.00
198 INT173505 Localization of Hand2 63 0.57 45.32 13.66 5.00
199 INT20264 Gene_expression of Chkb 29 0.46 13.14 13.65 5.00
200 INT15921 Positive_regulation of Serpine1 85 0.68 81.24 13.4 5.00
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