D:Nephrocalcinosis

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Disease Term
Synonyms NEPHROCALCINOSES
Documents 66
Hot Single Events 33
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Nephrocalcinosis. They are ordered first by their relevance to Nephrocalcinosis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT340380 Binding of Cfl1 and Clcn4-2 1 0.13 0.82 0 34.56
2 INT340377 Binding of Clcn4-2 and Clcn5 1 0.35 0.82 0 34.56
3 INT340378 Binding of Cfl1 and Clcn5 1 0.15 0.82 0 34.16
4 INT340379 Binding of Rabep1 and Ocrl 1 0.08 0.62 0 19.88
5 INT170832 Cftr Regulation of Scnn1a 2 0.16 1.2 0.67 5.00
6 INT257577 CALCA Positive_regulation of DMD 1 0.01 0.57 0.26 5.00
7 INT289836 BEST1 Positive_regulation of Gene_expression of Car2 1 0.03 0.08 0 5.00
8 INT257589 Negative_regulation of Pth Positive_regulation of DMD 1 0.01 0 0 5.00
9 INT257590 Pth Positive_regulation of DMD 2 0.02 0.44 0 5.00
10 INT283062 ERCC8 Positive_regulation of CFH 1 0.02 1.88 0 5.00
11 INT283061 Binding of ERCC8 and LDLR 1 0.00 0.44 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Nephrocalcinosis. They are ordered first by their pain relevance and then by number of times they were reported in Nephrocalcinosis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT340366 Gene_expression of Clcn5 1 0.77 4.8 0 98.84
2 INT340360 Positive_regulation of Clcn5 1 0.50 1.62 0 98.58
3 INT1533 Negative_regulation of AGT 105 0.42 46.54 16.92 98.16
4 INT135056 Positive_regulation of MTSS1 1 0.21 0.69 0 96.68
5 INT205654 Gene_expression of FUS 9 0.32 11.53 0.16 96.48
6 INT9292 Positive_regulation of SGCG 93 0.67 35.13 23.48 96.20
7 INT164753 Negative_regulation of Clcn5 2 0.58 5.13 0.2 95.84
8 INT340369 Negative_regulation of Tal 1 0.09 1.04 0 95.20
9 INT340373 Negative_regulation of Rbp4 1 0.17 1.96 0.16 93.76
10 INT6512 Gene_expression of PTH 103 0.77 76.29 6.33 91.60
11 INT6514 Positive_regulation of Gene_expression of PTH 28 0.67 30.28 1.37 91.60
12 INT149239 Gene_expression of Slc12a1 4 0.66 3.08 0.6 91.16
13 INT156431 Negative_regulation of Gene_expression of CLCNKB 1 0.05 1.09 0.29 91.16
14 INT156428 Negative_regulation of Gene_expression of Slc12a1 1 0.07 1.09 0.29 91.16
15 INT156432 Negative_regulation of Gene_expression of KCNJ1 1 0.41 1.09 0.29 91.16
16 INT156430 Gene_expression of KCNJ1 1 0.65 1.08 0.28 91.16
17 INT156429 Gene_expression of CLCNKB 1 0.07 1.08 0.28 91.16
18 INT152395 Binding of SLC34A3 1 0.09 1.27 0.08 91.04
19 INT295973 Gene_expression of Slc34a3 2 0.05 0.96 0.03 90.00
20 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85 88.08
21 INT1180 Gene_expression of Ren 63 0.77 27.33 10.51 87.52
22 INT19804 Negative_regulation of Hprt 18 0.59 20.6 2.17 87.04
23 INT98016 Protein_catabolism of Pth 2 0.18 2.07 0.18 85.88
24 INT67138 Gene_expression of Gc 19 0.31 17.11 4.1 85.52
25 INT425 Localization of PRL 455 0.81 189.64 144.8 84.80
26 INT252 Localization of GH1 529 0.80 227.4 122.05 84.80
27 INT6624 Gene_expression of Pth 135 0.76 110.27 27.54 84.40
28 INT129736 Negative_regulation of Casr 1 0.14 1.28 0.08 84.16
29 INT294932 Negative_regulation of Gc 6 0.17 3.38 0.71 82.48
30 INT289834 Positive_regulation of Protein_catabolism of LRP2 1 0.45 0.65 0.03 81.72
31 INT289835 Protein_catabolism of LRP2 1 0.96 0.58 0.03 81.72
32 INT233570 Gene_expression of Rbp4 4 0.66 3.4 0.17 80.56
33 INT218315 Gene_expression of RBP4 25 0.76 18.19 0.85 80.16
34 INT375 Positive_regulation of REN 293 0.70 152.46 47.55 76.24
35 INT340368 Binding of Ocrl 1 0.37 2.61 0 75.92
36 INT340362 Gene_expression of Ocrl 3 0.67 2.27 0 75.76
37 INT340367 Regulation of Gene_expression of Ocrl 1 0.45 1.11 0 75.76
38 INT82918 Binding of AMBP 23 0.39 23.31 1.71 74.88
39 INT340372 Negative_regulation of Protein_catabolism of Clcn5 1 0.43 1.07 0 71.52
40 INT915 Positive_regulation of PRL 342 0.70 141.96 104.31 70.08
41 INT340365 Protein_catabolism of Clcn5 1 0.99 1.03 0 70.08
42 INT914 Positive_regulation of GH1 292 0.69 100.7 84.91 68.00
43 INT16165 Regulation of DMD 114 0.60 35.13 3.64 68.00
44 INT957 Positive_regulation of GHRH 136 0.70 36.84 40.52 67.68
45 INT14902 Negative_regulation of XDH 38 0.55 24.19 2.86 65.32
46 INT340370 Negative_regulation of Ocrl 1 0.43 2.31 0 64.48
47 INT703 Positive_regulation of Pth 177 0.70 127.09 27.26 63.04
48 INT340359 Binding of Clcn5 1 0.48 1.91 0 61.68
49 INT340364 Negative_regulation of Gene_expression of Ocrl 1 0.43 1.16 0 58.00
50 INT129737 Positive_regulation of Casr 2 0.52 2.39 1.33 57.84
51 INT95446 Gene_expression of PHC2 2 0.32 1.59 0.3 50.04
52 INT3824 Negative_regulation of PTH 40 0.59 28.58 3.39 49.08
53 INT289822 Regulation of Gene_expression of Clcn3 1 0.05 0.91 0.04 48.36
54 INT215807 Gene_expression of Clcn3 5 0.19 3.2 0.48 48.12
55 INT289814 Negative_regulation of Clcn3 1 0.05 2.54 0.14 48.12
56 INT56433 Negative_regulation of Cl 3 0.13 1.87 0.35 48.00
57 INT55964 Localization of PHB2 1 0.39 0.79 0.07 46.24
58 INT192808 Negative_regulation of Localization of PTH 6 0.59 7.31 0.45 43.60
59 INT2544 Localization of PTH 39 0.81 30.55 2.22 43.20
60 INT340371 Regulation of Tal 1 0.10 0.85 0 40.80
61 INT340363 Regulation of Clcn5 1 0.45 0.85 0 39.12
62 INT4679 Negative_regulation of RAPGEF5 55 0.57 47.51 4.55 34.80
63 INT157409 Negative_regulation of Fgf23 3 0.50 3.21 0.27 34.64
64 INT340361 Binding of Clcn4-2 1 0.30 0.82 0 34.56
65 INT261239 Binding of XDH 10 0.34 3.16 0.31 29.72
66 INT223026 Regulation of XDH 2 0.32 2.38 0.15 29.72
67 INT144432 Positive_regulation of Transcription of Ccnd1 4 0.36 2.36 0.63 26.76
68 INT258832 Regulation of Transcription of Ccnd1 1 0.16 1.57 0.03 26.76
69 INT144427 Transcription of Ccnd1 10 0.41 7.89 1.07 26.20
70 INT181614 Positive_regulation of TDO2 2 0.45 2.18 0.18 25.44
71 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 23.96
72 INT170601 Positive_regulation of Gene_expression of GOPC 122 0.43 42.79 11.68 23.96
73 INT170604 Negative_regulation of Gene_expression of GOPC 50 0.35 12.71 4.51 23.96
74 INT340374 Binding of Rabep1 1 0.05 0.61 0 17.72
75 INT206982 Negative_regulation of TDO2 2 0.19 1.51 0 15.76
76 INT289825 Positive_regulation of Aqp6 2 0.21 0.62 0.07 14.24
77 INT102572 Gene_expression of Ccnd1 79 0.69 56.37 7.34 13.40
78 INT98609 Negative_regulation of PYGM 11 0.43 6.21 0.6 13.16
79 INT261265 Gene_expression of PYGM 2 0.17 1.96 0.24 13.16
80 INT9884 Localization of CD79A 41 0.78 21.75 3.06 11.44
81 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 6.32
82 INT158 Localization of Prl 2431 0.81 378.96 952.2 5.00
83 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
84 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82 5.00
85 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
86 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
87 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68 5.00
88 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
89 INT1893 Localization of Gh 1041 0.79 340.23 256.58 5.00
90 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
91 INT528 Gene_expression of Prl 693 0.78 217.18 192.2 5.00
92 INT159 Negative_regulation of Localization of Prl 416 0.59 55.34 171.8 5.00
93 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 5.00
94 INT2640 Gene_expression of Pomc 424 0.78 120.72 155.37 5.00
95 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
96 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 5.00
97 INT397 Localization of SST 232 0.81 58.05 101.19 5.00
98 INT3537 Positive_regulation of Car2 413 0.56 103.51 94.35 5.00
99 INT1498 Gene_expression of Gh 521 0.75 220.84 81.16 5.00
100 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 5.00
101 INT8347 Gene_expression of SST 181 0.78 104.59 65.45 5.00
102 INT30170 Gene_expression of Car2 330 0.66 77.26 46.76 5.00
103 INT17561 Localization of Car2 303 0.79 60.95 44.52 5.00
104 INT1894 Negative_regulation of Localization of Gh 168 0.58 64.12 43.56 5.00
105 INT5307 Regulation of Tnf 87 0.62 78.71 43.4 5.00
106 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 5.00
107 INT6105 Positive_regulation of IL2 133 0.69 82.76 34.67 5.00
108 INT10763 Localization of IL2 157 0.80 81.11 33.21 5.00
109 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7 5.00
110 INT35716 Positive_regulation of NCOR2 45 0.60 18 23.54 5.00
111 INT103842 Gene_expression of Cftr 53 0.78 59.59 21.82 5.00
112 INT105021 Binding of GOPC 187 0.40 60.39 20.38 5.00
113 INT756 Gene_expression of C3 138 0.75 100.6 19.2 5.00
114 INT712 Positive_regulation of LDHA 160 0.70 175.25 19.11 5.00
115 INT116978 Gene_expression of CCR6 53 0.78 56 17.73 5.00
116 INT14587 Positive_regulation of Cl 44 0.20 20.37 16.72 5.00
117 INT16167 Negative_regulation of DMD 186 0.57 108.71 15.25 5.00
118 INT16166 Positive_regulation of DMD 348 0.67 133.22 15.06 5.00
119 INT20665 Gene_expression of ACE 87 0.78 51.71 14.19 5.00
120 INT6478 Negative_regulation of Binding of TNF 36 0.58 30.42 13.31 5.00
121 INT91360 Negative_regulation of Slc12a2 16 0.54 10.46 12.89 5.00
122 INT4137 Positive_regulation of C3 73 0.69 48.57 12.63 5.00
123 INT36287 Binding of CD4 96 0.47 58.93 11.88 5.00
124 INT744 Positive_regulation of PTH 130 0.70 95.02 11.7 5.00
125 INT65713 Localization of ICAM1 42 0.81 39.55 11.49 5.00
126 INT25170 Positive_regulation of Localization of Car2 78 0.67 15.25 11.24 5.00
127 INT58904 Localization of TH1L 40 0.68 27.11 10.52 5.00
128 INT65058 Binding of Nfkb1 36 0.45 19.87 10.02 5.00
129 INT22083 Regulation of Pth 55 0.62 22.32 8.9 5.00
130 INT36449 Negative_regulation of G6PD 74 0.59 54.15 8.85 5.00
131 INT13085 Positive_regulation of ACE 50 0.70 44.2 8.31 5.00
132 INT44003 Gene_expression of F3 40 0.75 27.92 8.29 5.00
133 INT6625 Negative_regulation of Pth 96 0.58 57.6 8.24 5.00
134 INT92138 Binding of CDKN2A 28 0.37 25.64 7.47 5.00
135 INT91667 Localization of IL12A 39 0.74 25.51 7.36 5.00
136 INT69289 Negative_regulation of Cftr 44 0.57 13.28 6.97 5.00
137 INT5864 Localization of IL36RN 19 0.44 14.5 6.87 5.00
138 INT39516 Gene_expression of Alb 81 0.75 30.08 6.59 5.00
139 INT11826 Positive_regulation of LDLR 62 0.62 45.09 6.21 5.00
140 INT13396 Gene_expression of DMD 125 0.75 57.81 5.45 5.00
141 INT130300 Gene_expression of Abcc3 14 0.70 5.34 4.96 5.00
142 INT67182 Gene_expression of Tms 10 0.53 5.14 4.29 5.00
143 INT37380 Negative_regulation of Sis 31 0.55 19.89 3.92 5.00
144 INT148085 Binding of CXCL10 14 0.32 10.22 3.81 5.00
145 INT125479 Positive_regulation of HHIP 38 0.44 12.39 3.75 5.00
146 INT14880 Positive_regulation of Car3 14 0.65 9.19 3.73 5.00
147 INT93399 Gene_expression of Ccnd1 38 0.58 21 3.65 5.00
148 INT16236 Negative_regulation of CFH 31 0.57 19.59 3.36 5.00
149 INT171998 Binding of DMD 58 0.47 38.13 3.35 5.00
150 INT16234 Positive_regulation of CFH 25 0.50 26.05 3.33 5.00
151 INT262474 Gene_expression of Aqp6 26 0.77 2.08 2.49 5.00
152 INT1829 Gene_expression of CFH 71 0.75 64.24 2.49 5.00
153 INT204175 Localization of Mri1 12 0.60 2.73 2.35 5.00
154 INT95898 Gene_expression of CAPG 14 0.39 10.51 2.33 5.00
155 INT22715 Positive_regulation of Gene_expression of Pth 29 0.64 22.53 2.31 5.00
156 INT93396 Positive_regulation of Gene_expression of Ccnd1 13 0.52 8.59 2.26 5.00
157 INT9254 Negative_regulation of LDHA 23 0.43 13.3 2.2 5.00
158 INT125480 Regulation of HHIP 17 0.38 6.16 2.16 5.00
159 INT88701 Gene_expression of MMD 15 0.44 6.04 1.94 5.00
160 INT14149 Binding of C6orf25 11 0.48 9.04 1.71 5.00
161 INT103799 Positive_regulation of CAPG 8 0.34 5.16 1.52 5.00
162 INT247904 Localization of ICAM2 1 0.07 5.72 1.32 5.00
163 INT247903 Localization of ITGA1 1 0.06 5.69 1.32 5.00
164 INT23199 Binding of LDLR 22 0.47 17.08 1.16 5.00
165 INT123078 Negative_regulation of Kcnj1 2 0.10 0.87 1.09 5.00
166 INT13397 Localization of DMD 21 0.78 7.96 1.08 5.00
167 INT88820 Positive_regulation of Gene_expression of F3 8 0.67 5.48 1.08 5.00
168 INT46044 Positive_regulation of Gene_expression of C3 23 0.53 20.07 1.06 5.00
169 INT82702 Positive_regulation of Positive_regulation of LDLR 4 0.45 1.08 0.95 5.00
170 INT192686 Positive_regulation of Positive_regulation of DMD 8 0.41 4.66 0.93 5.00
171 INT109007 Positive_regulation of Ccnd1 23 0.53 9.5 0.86 5.00
172 INT52879 Negative_regulation of ATP6V0A1 2 0.24 0.64 0.82 5.00
173 INT23146 Negative_regulation of Aprt 8 0.56 7.53 0.71 5.00
174 INT67093 Binding of CASR 3 0.41 3.32 0.64 5.00
175 INT115423 Gene_expression of Men1 4 0.47 14.08 0.64 5.00
176 INT167705 Positive_regulation of Clcn2 3 0.46 1.32 0.63 5.00
177 INT67346 Regulation of Gene_expression of F3 2 0.13 1.42 0.6 5.00
178 INT238245 Gene_expression of Atp5s 4 0.75 7.57 0.6 5.00
179 INT168502 Positive_regulation of FUS 3 0.39 9.22 0.59 5.00
180 INT300623 Positive_regulation of Men1 1 0.35 10.65 0.57 5.00
181 INT300621 Localization of Men1 1 0.56 4.63 0.52 5.00
182 INT89217 Negative_regulation of ADAMTS13 8 0.50 12.32 0.51 5.00
183 INT258835 Localization of Ccnd1 3 0.53 2.7 0.5 5.00
184 INT196424 Binding of Ccnd1 5 0.29 3.34 0.47 5.00
185 INT153758 Binding of Mitf 5 0.47 2.5 0.46 5.00
186 INT178766 Negative_regulation of HHIP 19 0.28 11.1 0.43 5.00
187 INT173912 Negative_regulation of LRP2 5 0.57 6.22 0.42 5.00
188 INT149237 Gene_expression of Slc34a3 2 0.42 2.22 0.39 5.00
189 INT173940 Positive_regulation of Negative_regulation of DMD 8 0.59 2.97 0.36 5.00
190 INT246502 Negative_regulation of Men1 2 0.30 8.9 0.33 5.00
191 INT137153 Positive_regulation of VIS1 2 0.04 1.52 0.31 5.00
192 INT205651 Localization of FUS 4 0.36 4.15 0.31 5.00
193 INT210686 Regulation of F3 2 0.12 0.91 0.27 5.00
194 INT62068 Transcription of Pth 6 0.67 3.2 0.23 5.00
195 INT146801 Regulation of Ccnd1 5 0.34 2.4 0.19 5.00
196 INT194530 Gene_expression of UOX 17 0.65 11.78 0.17 5.00
197 INT246624 Binding of Abcc3 2 0.00 0.59 0.15 5.00
198 INT205657 Negative_regulation of FUS 3 0.21 6.61 0.14 5.00
199 INT257588 Regulation of Negative_regulation of DMD 2 0.03 0.96 0.14 5.00
200 INT262478 Binding of Clcn3 1 0.06 1.23 0.14 5.00
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