D:Nerve Compression Syndromes

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Disease Term
Synonyms Compression Syndrome Nerve, Compression Syndromes Nerve, ENTRAPMENT NERVE, Entrapment Neuropathies, ENTRAPMENT NEUROPATHY, Entrapments Nerve, External Nerve Compression Syndromes, Internal Nerve Compression Syndromes, NERVE COMPRESSION SYNDROME, Nerve Compression Syndromes External, Nerve Compression Syndromes Internal
Documents 772
Hot Single Events 105
Hot Interactions 6

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Nerve Compression Syndromes. They are ordered first by their relevance to Nerve Compression Syndromes and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT259776 Fbn2 Regulation of Negative_regulation of Agtr1a 1 0.00 1.42 0.66 100.00
2 INT259768 Positive_regulation of Agtr1a Regulation of Etf1 1 0.00 1.32 0.62 92.48
3 INT153740 TNFRSF11A Positive_regulation of Vcp 1 0.04 1.15 0.13 92.48
4 INT153739 TNFRSF11A Positive_regulation of Tnfrsf11b 1 0.05 1.14 0.13 92.48
5 INT153742 TNFRSF11A Positive_regulation of Tnfrsf11b 1 0.00 1.15 0.13 92.48
6 INT153738 TNFRSF11A Positive_regulation of SQSTM1 1 0.05 1.22 0.13 92.48
7 INT280276 Binding of Tgfb1 and Positive_regulation of VEGFA 1 0.02 1.27 0 30.76
8 INT280262 Binding of Tgfb1 and Positive_regulation of Cxcr4 1 0.07 1.27 0 30.20
9 INT101942 Binding of CD40 and CD40LG 16 0.23 15.24 4.01 5.00
10 INT284860 Binding of Pdzd2 and Nav1 9 0.29 2.33 2.34 5.00
11 INT284855 Binding of S100a10 and Nav1 4 0.21 0.99 0.88 5.00
12 INT180496 Binding of CTS and PDXK 1 0.04 0.69 0.77 5.00
13 INT324065 Ptger2 Positive_regulation of Prkaca 2 0.24 0.63 0.61 5.00
14 INT342689 Ptger4 Positive_regulation of Prkaca 1 0.03 0.24 0.51 5.00
15 INT342693 Binding of Prkaca and Gopc 1 0.01 0.23 0.48 5.00
16 INT342687 Pdzd2 Regulation of Gene_expression of Nav1 1 0.19 0.3 0.35 5.00
17 INT342691 Pdzd2 Regulation of Nav1 1 0.19 0.48 0.34 5.00
18 INT280260 Tgfb1 Positive_regulation of Cxcr1 1 0.07 1.78 0.19 5.00
19 INT188985 Binding of MKLN1 and CHPT1 1 0.06 0 0.19 5.00
20 INT280270 Tgfb1 Positive_regulation of Gene_expression of Cxcr4 1 0.08 1.81 0.19 5.00
21 INT280275 Tgfb1 Positive_regulation of VEGFA 1 0.02 2.46 0.19 5.00
22 INT280268 Tgfb1 Positive_regulation of Gene_expression of Vegfa 1 0.06 1.81 0.19 5.00
23 INT280266 Tgfb1 Positive_regulation of Vegfa 1 0.09 1.8 0.19 5.00
24 INT280261 Tgfb1 Positive_regulation of Gene_expression of Cxcr1 1 0.05 1.81 0.19 5.00
25 INT280267 Tgfb1 Positive_regulation of Cxcr4 1 0.11 2.45 0.19 5.00
26 INT280274 Tgfb1 Positive_regulation of Gene_expression of VEGFA 1 0.02 2.58 0.19 5.00
27 INT342688 Binding of Cap1 and Nav1 1 0.00 0.19 0.14 5.00
28 INT342692 Binding of Gopc and Nav1 1 0.02 0.15 0.1 5.00
29 INT342694 Binding of Pdzd2 and Gopc 1 0.03 0.15 0.1 5.00
30 INT342690 Binding of Sft2d3 and Pdzd2 1 0.00 0.15 0.09 5.00
31 INT276141 Binding of Gh and Igf1 2 0.34 0.66 0.08 5.00
32 INT328667 Binding of CD40LG and CSF2 1 0.16 0.59 0.05 5.00
33 INT328668 Binding of CSF2 and IGHG3 1 0.03 0.59 0.05 5.00
34 INT280263 Binding of Smad4 and Proc 1 0.00 1.26 0.03 5.00
35 INT280265 Binding of Cxcr4 and Tgfb1 1 0.06 0.89 0 5.00
36 INT280272 VEGFA Regulation of Cxcr4 1 0.05 0.87 0 5.00
37 INT280269 Tgfb1 Regulation of Cxcr4 1 0.04 0.88 0 5.00
38 INT280264 Negative_regulation of Binding of Cxcr4 and Tgfb1 1 0.07 0.89 0 5.00
39 INT280273 Tgfb1 Regulation of VEGFA 1 0.01 0.88 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Nerve Compression Syndromes. They are ordered first by their pain relevance and then by number of times they were reported in Nerve Compression Syndromes. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT259762 Positive_regulation of Fbn2 4 0.05 6.74 2.55 100.00
2 INT259760 Localization of Fbn2 5 0.05 5.55 2.85 100.00
3 INT171145 Positive_regulation of Fig4 274 0.59 93.55 69.81 100.00
4 INT5793 Binding of CTS 110 0.48 63.91 40.62 100.00
5 INT259763 Regulation of Fbn2 1 0.02 1.47 0.76 100.00
6 INT259766 Positive_regulation of Localization of Fbn2 1 0.03 3.09 1.51 100.00
7 INT259764 Negative_regulation of Positive_regulation of Fbn2 1 0.03 1.7 0.6 100.00
8 INT266562 Gene_expression of Fbn2 1 0.05 0.93 0.84 100.00
9 INT266563 Positive_regulation of Gene_expression of Fbn2 1 0.04 0.93 0.84 100.00
10 INT259761 Negative_regulation of Fbn2 2 0.03 1.1 0.34 100.00
11 INT259765 Phosphorylation of Fbn2 1 0.05 0.99 0.57 100.00
12 INT266560 Positive_regulation of Positive_regulation of Fbn2 1 0.05 0.5 0.26 100.00
13 INT29046 Positive_regulation of Etf1 32 0.12 12.03 21.06 99.98
14 INT266570 Positive_regulation of Binding of Nav1 3 0.44 1.45 2.2 99.96
15 INT117676 Positive_regulation of Transcription of Nav1 8 0.53 4.37 7.75 99.96
16 INT100965 Positive_regulation of Nav1 85 0.70 37.74 75.35 99.84
17 INT97366 Regulation of Nav1 38 0.62 23.63 38.17 99.84
18 INT10982 Negative_regulation of Agtr1a 42 0.58 22.42 10.29 99.84
19 INT153194 Positive_regulation of Positive_regulation of Nav1 5 0.50 3.44 4.24 99.84
20 INT94199 Regulation of DRGX 9 0.07 8.31 10.39 99.84
21 INT97368 Negative_regulation of Nav1 62 0.59 41.56 60.27 99.82
22 INT170646 Negative_regulation of Fig4 213 0.37 81.29 46.92 99.76
23 INT163962 Regulation of Transcription of Nav1 2 0.35 3.25 2.63 99.72
24 INT110633 Binding of Nav1 15 0.42 4.34 9.38 99.72
25 INT328692 Gene_expression of Mir206 1 0.33 4.14 0.33 99.68
26 INT328691 Transcription of Kcne2 1 0.07 0.54 0.03 99.50
27 INT74838 Positive_regulation of Sorbs1 18 0.34 6.93 12.63 99.44
28 INT266561 Negative_regulation of Positive_regulation of Sorbs1 1 0.01 1.01 0.88 99.44
29 INT328690 Transcription of Mir133a 1 0.44 0.54 0.03 99.30
30 INT145971 Localization of Nav1 20 0.81 10.3 18.11 99.28
31 INT29045 Regulation of Etf1 10 0.05 5.93 8.7 99.28
32 INT328680 Negative_regulation of Mir133a 1 0.37 1.61 0.2 99.20
33 INT66776 Negative_regulation of Kcne2 6 0.35 2.48 0.33 99.20
34 INT87497 Positive_regulation of Cadps 2 0.22 1.77 2.19 99.20
35 INT259773 Negative_regulation of Rs1 1 0.00 3 1.38 99.08
36 INT328679 Positive_regulation of Mir499 1 0.16 0.24 0 99.00
37 INT117675 Transcription of Nav1 46 0.72 30.23 44.01 98.92
38 INT266567 Regulation of Localization of Nav1 1 0.21 1.89 0.83 98.72
39 INT38479 Positive_regulation of Kcne2 4 0.40 1 0.63 98.64
40 INT20672 Gene_expression of CDS1 19 0.76 8.19 4.08 98.58
41 INT97367 Gene_expression of Nav1 243 0.78 132.97 286.66 98.56
42 INT95670 Regulation of PDB1 4 0.60 5.59 0.55 98.56
43 INT83553 Positive_regulation of Positive_regulation of Agtr1a 3 0.59 4.12 1.37 98.54
44 INT146917 Localization of Slmap 4 0.80 1.56 0.42 98.44
45 INT328683 Positive_regulation of Mir133a 1 0.30 0.24 0 98.36
46 INT53038 Positive_regulation of Agtr1a 35 0.67 23.76 11.68 98.34
47 INT134717 Positive_regulation of Rs1 2 0.07 3.71 2.31 98.32
48 INT29047 Negative_regulation of Etf1 18 0.08 9.6 11.12 98.00
49 INT29044 Positive_regulation of Negative_regulation of Etf1 2 0.01 0.99 1.13 98.00
50 INT153496 Negative_regulation of Pmp22 2 0.42 3.34 0.26 97.72
51 INT2093 Gene_expression of GAST 50 0.78 32.32 7.98 97.60
52 INT59665 Positive_regulation of Ugt1a6 24 0.69 7.24 13.25 97.52
53 INT328677 Gene_expression of Mir133a 1 0.50 6.11 0.38 97.24
54 INT15998 Gene_expression of Kcne2 7 0.46 8.1 1.61 97.24
55 INT328687 Negative_regulation of Gene_expression of Mir133a 1 0.37 2.26 0.12 97.24
56 INT328694 Negative_regulation of Gene_expression of Kcne2 1 0.06 2.16 0.08 97.24
57 INT328685 Positive_regulation of Mir139 1 0.06 0.23 0 97.20
58 INT6623 Gene_expression of NA 231 0.78 45.78 59.36 96.56
59 INT142690 Positive_regulation of Gene_expression of DRGX 10 0.23 8.54 5.69 95.40
60 INT45142 Gene_expression of DCPS 109 0.56 84.71 16.87 95.24
61 INT55224 Gene_expression of DRGX 99 0.31 67.55 67.63 95.00
62 INT19428 Gene_expression of MTRF1 42 0.08 27.17 10.43 94.16
63 INT27551 Gene_expression of SERPINH1 45 0.62 42.87 9.04 94.16
64 INT112626 Positive_regulation of Cts 5 0.59 8.03 4.59 93.88
65 INT103236 Positive_regulation of Positive_regulation of P2ry1 5 0.54 2.39 1.92 93.16
66 INT69166 Positive_regulation of P2ry1 35 0.67 8.41 13.63 92.76
67 INT6559 Gene_expression of Cox6c 7 0.63 1.5 1.04 92.68
68 INT177581 Regulation of Fig4 113 0.41 39.26 27.75 92.40
69 INT266566 Regulation of Transcription of Fig4 2 0.11 0.56 0.23 92.40
70 INT328693 Regulation of Gene_expression of Mir133a 1 0.29 0.72 0 91.76
71 INT328678 Regulation of Gene_expression of Kcne2 1 0.05 0.72 0 91.76
72 INT318440 Positive_regulation of Mir21 10 0.33 5.93 0.86 91.52
73 INT4535 Localization of PROC 106 0.73 76.24 21.1 91.36
74 INT173751 Transcription of Fig4 31 0.46 8.28 3.7 91.28
75 INT61635 Positive_regulation of P2ry2 35 0.56 12.08 14.68 90.96
76 INT259771 Binding of Rs1 1 0.00 0.42 0.33 90.80
77 INT69748 Regulation of Kcne2 2 0.03 1.01 0.3 90.64
78 INT72538 Negative_regulation of Sorbs1 7 0.59 4.49 4.61 90.44
79 INT328689 Negative_regulation of Regulation of Mir133a 1 0.28 0.55 0.08 90.24
80 INT328688 Regulation of Mir133a 1 0.17 0.54 0.08 90.24
81 INT39730 Gene_expression of PFDN4 4 0.75 2.4 0.59 90.08
82 INT125767 Positive_regulation of Gene_expression of S100b 6 0.49 4.08 1.52 89.28
83 INT328686 Positive_regulation of Gene_expression of Mir133a 1 0.44 0.82 0.1 88.68
84 INT328682 Positive_regulation of Gene_expression of Kcne2 1 0.07 0.82 0.1 88.68
85 INT1279 Negative_regulation of Cox6c 10 0.30 3.1 2.82 88.48
86 INT23465 Gene_expression of S100b 31 0.76 15.09 6.2 88.40
87 INT33053 Positive_regulation of Cox6c 9 0.69 3.74 2.23 88.32
88 INT64076 Positive_regulation of Kcnma1 47 0.40 11.52 24.19 88.28
89 INT72252 Gene_expression of Kcnma1 63 0.64 20.47 29.56 87.08
90 INT37983 Negative_regulation of PPFIBP1 3 0.57 2.12 1.29 86.92
91 INT117674 Regulation of Gene_expression of Nav1 16 0.62 11.5 22.01 86.80
92 INT177471 Localization of MTRF1 5 0.06 3.46 1.4 86.68
93 INT87941 Negative_regulation of DRGX 11 0.13 7.14 6.74 85.96
94 INT115909 Positive_regulation of Gene_expression of Nav1 25 0.70 16.58 27.63 85.92
95 INT266569 Negative_regulation of Gene_expression of Cadps 1 0.13 0.51 0.37 85.04
96 INT48074 Negative_regulation of Cadps 3 0.34 0.74 1.57 85.04
97 INT328681 Positive_regulation of Gene_expression of Mir206 1 0.29 1.86 0.18 83.52
98 INT76249 Gene_expression of Gria1 67 0.75 15.07 22.78 82.88
99 INT112640 Positive_regulation of Negative_regulation of Nav1 3 0.50 1.26 2.98 82.24
100 INT111053 Positive_regulation of Positive_regulation of Nav1 4 0.46 2.97 3.53 81.28
101 INT216770 Gene_expression of Cadps 3 0.34 0.86 0.6 81.04
102 INT1894 Negative_regulation of Localization of Gh 168 0.58 64.12 43.56 81.00
103 INT103261 Positive_regulation of Nav1 68 0.70 24.25 39.27 80.72
104 INT1893 Localization of Gh 1041 0.79 340.23 256.58 80.64
105 INT321617 Negative_regulation of IMAGE 1 0.01 0.44 0.12 80.64
106 INT58238 Localization of Aspn 1 0.00 0.32 0.15 79.76
107 INT266565 Positive_regulation of Localization of Nav1 1 0.36 1.24 0.89 79.68
108 INT58237 Localization of Tcl1 3 0.58 0.94 0.4 79.36
109 INT12161 Positive_regulation of P2rx2 70 0.69 34.22 34.4 79.36
110 INT285 Positive_regulation of Salpa1 73 0.68 61.47 9.19 79.28
111 INT259774 Negative_regulation of Positive_regulation of P2ry1 1 0.33 1.11 0.54 78.72
112 INT96034 Negative_regulation of Proc 11 0.33 10.21 1.18 78.00
113 INT24080 Negative_regulation of Mtor 64 0.37 41.56 5.19 77.84
114 INT114164 Negative_regulation of Slmap 2 0.32 0.92 0.32 77.76
115 INT100661 Regulation of Cst7 18 0.53 5.93 7.8 77.68
116 INT106152 Negative_regulation of Regulation of Cst7 1 0.36 0.69 0.99 77.68
117 INT213533 Positive_regulation of Gene_expression of Proc 6 0.01 5.55 0.49 77.36
118 INT63164 Negative_regulation of Cst7 51 0.50 18.48 20.3 77.28
119 INT147008 Negative_regulation of Gene_expression of S100b 2 0.27 0.55 0.74 77.20
120 INT109005 Gene_expression of Proc 61 0.75 37.86 8.49 76.68
121 INT1497 Negative_regulation of Gh 415 0.59 192.95 74.71 76.56
122 INT18357 Gene_expression of TRPV1 825 0.78 307.11 382.81 76.48
123 INT172559 Localization of Proc 16 0.02 21.49 2.08 75.48
124 INT19763 Gene_expression of CTs 69 0.78 32.92 18.87 75.36
125 INT14556 Positive_regulation of Igf1 105 0.69 52.21 24.04 74.96
126 INT10841 Positive_regulation of Gene_expression of Gh 101 0.59 45.39 16.96 74.96
127 INT115790 Negative_regulation of P2rx6 8 0.47 4.13 3.19 74.16
128 INT215788 Localization of P2rx6 3 0.42 1.84 0.59 74.16
129 INT14559 Gene_expression of Igf1 254 0.78 112 34.17 73.60
130 INT19104 Regulation of Gene_expression of Gh 24 0.40 8.42 3.88 73.52
131 INT142174 Regulation of Gene_expression of Igf1 28 0.60 11.86 3.77 73.52
132 INT1498 Gene_expression of Gh 521 0.75 220.84 81.16 73.08
133 INT133386 Positive_regulation of PNKD 2 0.45 1.71 0.69 72.76
134 INT88098 Positive_regulation of 3110062M04Rik 10 0.48 4.37 4.45 72.64
135 INT174876 Regulation of Gene_expression of Fig4 18 0.39 7.83 2.44 71.64
136 INT170025 Gene_expression of Fig4 588 0.67 183.27 113.32 70.52
137 INT318448 Positive_regulation of Gene_expression of Mir21 11 0.33 6.31 1.12 70.00
138 INT11146 Negative_regulation of CTS 26 0.51 10.33 8.77 69.56
139 INT318449 Gene_expression of Mir21 18 0.37 11.92 1.46 69.36
140 INT259775 Positive_regulation of Positive_regulation of Rs1 1 0.00 1.07 0.53 68.72
141 INT61925 Negative_regulation of Adk 53 0.59 22.46 40.38 67.92
142 INT328684 Negative_regulation of Mir672 1 0.15 0.12 0.04 66.84
143 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 66.72
144 INT28151 Positive_regulation of CTs 55 0.61 35.09 20.14 63.00
145 INT75742 Binding of RLS 86 0.42 95.27 19.04 61.08
146 INT266564 Negative_regulation of Protein_catabolism of Nav1 1 0.29 0.42 0.34 58.60
147 INT266568 Protein_catabolism of Nav1 1 0.44 0.41 0.33 57.60
148 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 57.32
149 INT168003 Localization of Fgf2 24 0.80 12.52 3.31 57.32
150 INT80452 Positive_regulation of Gene_expression of Pthlh 4 0.40 3.77 0.62 56.04
151 INT74161 Positive_regulation of Negative_regulation of Adk 10 0.50 3.3 6.77 55.60
152 INT46530 Gene_expression of Pthlh 15 0.78 11.23 1.7 55.44
153 INT13409 Gene_expression of NEUROD1 52 0.75 14.17 12.23 54.88
154 INT188993 Gene_expression of MKLN1 2 0.38 9.71 1.43 54.80
155 INT188994 Positive_regulation of Gene_expression of MKLN1 1 0.10 0.51 0.03 54.80
156 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 54.64
157 INT47459 Gene_expression of Rac1 101 0.68 45.27 24.33 54.52
158 INT52631 Regulation of M3c 13 0.53 7.39 5.17 54.40
159 INT141841 Negative_regulation of Transcription of Nav1 3 0.43 3.15 4.38 53.52
160 INT78251 Positive_regulation of LBP 38 0.69 39.98 26.73 50.00
161 INT146812 Negative_regulation of Gene_expression of CTS 3 0.37 0 0.03 50.00
162 INT318431 Negative_regulation of Gene_expression of Mir21 2 0.20 1.07 0 50.00
163 INT164205 Binding of Proc 12 0.36 12.31 1.19 48.68
164 INT54924 Gene_expression of RLS 67 0.62 83.2 14.25 48.00
165 INT172555 Positive_regulation of Localization of Proc 1 0.00 1.82 0 46.80
166 INT189003 Localization of CHPT1 8 0.64 4.75 1.82 46.16
167 INT46833 Positive_regulation of SGSM3 56 0.67 24.49 30.31 45.52
168 INT280235 Localization of Me2 1 0.01 1.67 0 45.44
169 INT48198 Binding of Tgfb1 29 0.47 19.59 2.46 45.04
170 INT2540 Negative_regulation of Calca 538 0.59 172.11 384.38 43.92
171 INT14301 Binding of CSF2 82 0.48 67.95 8.98 40.28
172 INT9130 Negative_regulation of TGFB1 16 0.41 12.21 2.92 40.20
173 INT8101 Binding of INCENP 42 0.31 16.2 6.68 40.04
174 INT9500 Negative_regulation of Ceacam1 26 0.58 6.89 3.91 37.56
175 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 36.48
176 INT9647 Gene_expression of PROC 163 0.65 89.76 26.75 33.28
177 INT234111 Gene_expression of NCS1 3 0.74 15.23 2.68 32.76
178 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 30.76
179 INT126476 Positive_regulation of Cxcr4 25 0.69 19.01 1.72 30.20
180 INT99444 Positive_regulation of Proc 15 0.45 9.18 1.75 26.44
181 INT99445 Positive_regulation of Positive_regulation of Proc 2 0.39 1.6 0.07 26.44
182 INT2541 Binding of Calca 200 0.48 67.14 134.62 25.00
183 INT47950 Negative_regulation of ELOVL1 15 0.41 20.33 1.41 23.52
184 INT111476 Gene_expression of TP63 88 0.76 61.08 11.64 23.16
185 INT194850 Positive_regulation of Adora2b 43 0.61 20.57 13.89 16.00
186 INT50227 Positive_regulation of Adora2a 32 0.50 5.17 12.75 16.00
187 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 14.72
188 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 13.56
189 INT89404 Regulation of Negative_regulation of TNF 30 0.45 24.47 12.71 12.24
190 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 9.24
191 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 9.24
192 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 9.24
193 INT141300 Positive_regulation of Acvrl1 2 0.18 2.12 1.43 7.36
194 INT2542 Localization of Calca 2008 0.81 518.3 1408.65 5.00
195 INT2543 Positive_regulation of Calca 787 0.70 331.13 592.08 5.00
196 INT2649 Regulation of Calca 433 0.62 146.05 330.95 5.00
197 INT9381 Positive_regulation of TRPV1 523 0.70 187.4 276.05 5.00
198 INT94450 Gene_expression of Nav1 359 0.78 131.85 275.46 5.00
199 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
200 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
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