D:Nerve Sheath Neoplasms

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Disease Term
Synonyms MALIGNANT PERIPHERAL NERVE SHEATH TUMORS, MPNST, Mpnsts, NEOPLASM NERVE SHEATH, Neoplasms Nerve Sheath, Nerve Sheath Neoplasm, NERVE SHEATH TUMORS, Nerve Sheath Tumors Peripheral, Perineurioma, Perineuriomas, Peripheral Nerve Sheath Tumors
Documents 126
Hot Single Events 81
Hot Interactions 8

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Nerve Sheath Neoplasms. They are ordered first by their relevance to Nerve Sheath Neoplasms and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT156829 EGF Positive_regulation of MAPK3 2 0.08 0.87 0.1 95.76
2 INT177945 EGF Regulation of ras 1 0.02 0.84 0 91.72
3 INT177912 EGF Regulation of MAPK3 1 0.02 0.84 0 91.72
4 INT352297 Regulation of Binding of CD99 and VIM 1 0.19 1.07 0.06 81.12
5 INT352299 Regulation of Binding of BCL2 and VIM 1 0.10 1.07 0.06 81.12
6 INT244656 Binding of S100B and SLC4A1 1 0.14 1.72 0.03 80.40
7 INT352296 Binding of CD99 and VIM 1 0.16 1.06 0.06 80.36
8 INT352298 Binding of BCL2 and VIM 1 0.09 1.06 0.06 80.36
9 INT177915 EGF Positive_regulation of Phosphorylation of AKT1 1 0.03 0.51 0 63.44
10 INT177914 PRKG1 Positive_regulation of Phosphorylation of MAPK8 1 0.02 1.07 0.14 50.00
11 INT177911 PRKG1 Positive_regulation of MAPK8 1 0.02 1.07 0.14 50.00
12 INT177916 PRKG1 Positive_regulation of Positive_regulation of MAP3K1 1 0.05 1.07 0.14 50.00
13 INT177917 Positive_regulation of EGF Positive_regulation of Phosphorylation of MAPK3 1 0.04 0.4 0 50.00
14 INT177913 EGF Positive_regulation of Phosphorylation of MAPK3 1 0.04 0.4 0 50.00
15 INT311666 Binding of BCL2 and TP53 1 0.19 1.26 0.14 42.96
16 INT225230 Ad Positive_regulation of Nf2 1 0.04 1.37 0.04 5.00
17 INT225228 Binding of Cdk4 and Cdkn2a 1 0.21 1.24 0 5.00
18 INT225229 Binding of Cdk6 and Cdkn2a 1 0.19 1.25 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Nerve Sheath Neoplasms. They are ordered first by their pain relevance and then by number of times they were reported in Nerve Sheath Neoplasms. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT68216 Binding of NF1 40 0.48 51.24 4.59 99.98
2 INT64700 Binding of Nf1 14 0.45 15.24 2.29 99.98
3 INT21685 Gene_expression of ras 115 0.66 85.6 7.76 99.86
4 INT24326 Gene_expression of Ngf 346 0.78 218.67 184.71 99.84
5 INT20210 Localization of Ngf 69 0.79 46.22 38.57 99.84
6 INT145302 Positive_regulation of Sox9 2 0.48 1.42 0.03 99.80
7 INT80690 Positive_regulation of MAPK8 223 0.68 125.63 36.75 99.76
8 INT109914 Positive_regulation of MAPK9 16 0.56 7.64 3.27 99.76
9 INT96424 Transcription of Bmp2 6 0.69 6.34 1.11 99.56
10 INT84945 Transcription of BMP2 5 0.61 1.8 0.36 99.56
11 INT21687 Positive_regulation of ras 143 0.58 97.34 27.31 99.40
12 INT17101 Positive_regulation of Gene_expression of Edn1 24 0.69 24.9 8.86 99.18
13 INT6364 Gene_expression of Edn1 123 0.78 73.76 28.43 98.98
14 INT62684 Negative_regulation of TP53 66 0.58 66.09 4.62 98.96
15 INT120693 Positive_regulation of MEPE 7 0.50 8.22 0.79 98.90
16 INT78248 Negative_regulation of Cdkn2a 17 0.59 15.15 2.8 98.88
17 INT134661 Negative_regulation of Tp53 11 0.43 10.91 1.13 98.88
18 INT166312 Negative_regulation of Vim 7 0.22 5.9 0.46 98.84
19 INT91618 Positive_regulation of Phosphorylation of MAPK3 21 0.67 7.99 7.65 98.64
20 INT88070 Binding of Ema 7 0.18 7.39 0.31 98.52
21 INT71781 Phosphorylation of MAPK3 62 0.80 27.73 23.73 98.48
22 INT23954 Negative_regulation of Mb 24 0.49 11.27 2.55 98.06
23 INT23956 Negative_regulation of DES 12 0.42 10.84 1.82 98.06
24 INT58563 Negative_regulation of S100B 13 0.51 11.75 1.77 97.68
25 INT204170 Binding of Mri1 5 0.22 4.45 1.11 97.56
26 INT49650 Gene_expression of Nf1 4 0.76 3.38 0.67 97.48
27 INT17739 Gene_expression of S100B 226 0.78 132.7 26.4 97.38
28 INT15390 Positive_regulation of Edn1 64 0.70 47.36 23.8 97.32
29 INT169558 Positive_regulation of NF1 13 0.59 13.58 0 96.24
30 INT175423 Positive_regulation of TSC1 25 0.36 21.81 0.45 96.24
31 INT71787 Positive_regulation of MAPK3 37 0.67 17.5 17.88 95.76
32 INT87288 Positive_regulation of Positive_regulation of MAPK3 5 0.67 1.62 3.04 95.76
33 INT102532 Protein_catabolism of Casp3 24 0.64 16.78 1.64 95.52
34 INT87282 Regulation of MAPK3 9 0.60 7.61 1.65 94.36
35 INT151343 Gene_expression of UBE2D1 2 0.56 3.48 0.15 94.36
36 INT11775 Gene_expression of Ema 39 0.65 38.12 2.99 94.20
37 INT47451 Positive_regulation of Positive_regulation of ras 18 0.35 10.07 4.6 94.00
38 INT56925 Negative_regulation of TSC1 54 0.52 63.39 1.87 93.92
39 INT177938 Negative_regulation of NF1 9 0.43 10.3 0.2 93.92
40 INT126734 Positive_regulation of MDM2 8 0.49 5.56 0 93.92
41 INT116950 Negative_regulation of MAPK8 103 0.57 44.48 17.53 93.80
42 INT157362 Negative_regulation of MAPK9 7 0.35 4.27 1.44 93.80
43 INT79270 Gene_expression of MKI67 113 0.77 63.52 3.38 92.92
44 INT71786 Phosphorylation of MAPK1 256 0.82 110.09 46.17 92.68
45 INT115190 Binding of MAPK9 1 0.27 0.84 0.39 92.08
46 INT49325 Gene_expression of Cd34 102 0.78 82.75 8.97 92.08
47 INT122937 Binding of MLF1IP 1 0.19 1.83 0.11 92.00
48 INT173647 Positive_regulation of Gene_expression of MAPK14 15 0.39 7.54 2.05 91.92
49 INT177935 Positive_regulation of Positive_regulation of MAPK9 3 0.14 1.03 0.03 91.92
50 INT22080 Regulation of ras 40 0.53 36.24 4.44 91.72
51 INT31116 Gene_expression of Casp3 192 0.78 78.21 57.43 91.60
52 INT150693 Gene_expression of CLDN1 3 0.14 6.63 0.38 91.36
53 INT69264 Gene_expression of KIT 207 0.78 179.41 8.95 91.20
54 INT131931 Binding of KRT7 13 0.36 19.24 0.5 91.20
55 INT142874 Positive_regulation of Tyw1 1 0.02 0.64 0.34 91.20
56 INT85085 Positive_regulation of KIT 36 0.53 30.08 2.17 90.56
57 INT65600 Positive_regulation of Casp3 376 0.70 198.44 128.03 89.68
58 INT177936 Positive_regulation of Negative_regulation of MAPK8 3 0.50 2.1 0.63 89.68
59 INT177939 Positive_regulation of Negative_regulation of MAPK9 1 0.11 0.74 0.16 89.68
60 INT27954 Positive_regulation of Gene_expression of Ngf 87 0.70 57.91 51.96 88.72
61 INT27955 Negative_regulation of Gene_expression of Ngf 16 0.59 10.43 10.17 88.72
62 INT202316 Gene_expression of SCGB3A1 1 0.11 1.62 0 88.24
63 INT172209 Regulation of HAL 3 0.25 2.23 0.13 87.36
64 INT5841 Gene_expression of Vim 181 0.72 138.54 16.33 86.92
65 INT84894 Gene_expression of Calb2 45 0.73 24.65 7.81 86.92
66 INT96423 Gene_expression of Bmp2 61 0.78 25.07 3.01 86.32
67 INT58192 Positive_regulation of MRI1 86 0.61 53.81 24.68 86.32
68 INT1624 Gene_expression of Cea 212 0.76 180.44 34.21 86.16
69 INT10214 Gene_expression of VIM 153 0.78 115.88 16.29 85.92
70 INT128472 Negative_regulation of CD34 7 0.42 3.92 0.58 85.76
71 INT132507 Gene_expression of CAMKK2 2 0.25 0.57 0.09 85.24
72 INT6810 Gene_expression of ENO2 70 0.78 54.8 8.35 84.76
73 INT177587 Regulation of Gene_expression of MRI1 4 0.22 0.88 0.97 84.60
74 INT61993 Gene_expression of NF1 29 0.78 34.47 1.23 84.52
75 INT56749 Gene_expression of PCNA 219 0.77 111.25 18.42 84.24
76 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98 84.20
77 INT21686 Positive_regulation of Gene_expression of ras 19 0.42 13.79 4.28 83.76
78 INT109327 Negative_regulation of KIT 42 0.57 43.2 2.15 83.56
79 INT86534 Positive_regulation of MAPK14 81 0.62 57.81 23.62 83.52
80 INT29441 Negative_regulation of Gene_expression of Cea 6 0.20 5.97 0.55 81.84
81 INT95652 Gene_expression of Krt20 54 0.61 53.69 3.31 81.52
82 INT33220 Negative_regulation of ras 110 0.58 70.21 9.19 79.36
83 INT177934 Regulation of Gene_expression of NF1 1 0.19 1.23 0 78.56
84 INT171924 Gene_expression of MAPK14 60 0.65 54.38 21.68 78.00
85 INT79432 Positive_regulation of Calb2 7 0.23 6.59 0.61 77.92
86 INT96422 Gene_expression of Bmp4 18 0.69 3.26 0.63 76.40
87 INT129771 Regulation of SMARCB1 5 0.58 8.92 0.58 75.48
88 INT6361 Localization of Edn1 30 0.81 19.09 9.7 75.44
89 INT132103 Positive_regulation of Gene_expression of MAPK8 26 0.46 16.54 3.94 75.04
90 INT67097 Gene_expression of MIB1 20 0.75 21.06 1.03 75.04
91 INT177943 Positive_regulation of Gene_expression of MAPK9 2 0.11 0.81 0.15 75.04
92 INT36200 Gene_expression of S100A1 9 0.77 9.56 0.75 75.00
93 INT48219 Gene_expression of SLC4A1 34 0.75 33.18 2.84 75.00
94 INT48217 Gene_expression of SLC4A3 22 0.75 21.12 2.17 75.00
95 INT25963 Gene_expression of DES 122 0.75 98.81 11.25 75.00
96 INT18672 Gene_expression of Ncam1 54 0.78 36.64 18.79 75.00
97 INT113980 Gene_expression of Cald1 4 0.05 7.16 0.33 75.00
98 INT171666 Regulation of GOPC 117 0.39 40.41 15.47 74.92
99 INT34692 Negative_regulation of Positive_regulation of ras 5 0.45 3.86 1.08 73.60
100 INT259041 Binding of D18Tlj1e 1 0.03 1.98 0.57 73.24
101 INT80685 Gene_expression of MAPK8 90 0.72 51.91 13.36 73.04
102 INT177940 Gene_expression of MAPK9 5 0.56 2.77 0.73 72.80
103 INT84510 Positive_regulation of Nf1 8 0.69 9.52 1.93 71.96
104 INT105336 Regulation of AKT1 52 0.56 32.53 4.89 71.68
105 INT109929 Phosphorylation of MAPK8 102 0.81 39.98 16.54 71.36
106 INT51607 Positive_regulation of DES 33 0.67 32.24 3.29 71.04
107 INT249062 Positive_regulation of Positive_regulation of DES 1 0.49 1.29 0.03 71.04
108 INT6557 Gene_expression of Eno2 65 0.77 54.42 8.17 70.92
109 INT36798 Gene_expression of Mki67 178 0.77 132 8.24 70.48
110 INT83212 Positive_regulation of Gene_expression of Mki67 21 0.55 17.53 0.39 70.48
111 INT37227 Regulation of EGF 19 0.45 11.16 5.17 70.00
112 INT103262 Localization of Nav1 53 0.81 19.23 34.44 66.44
113 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71 65.24
114 INT89794 Positive_regulation of CDKN2A 58 0.67 50.18 5.38 65.24
115 INT92141 Negative_regulation of CDKN2A 53 0.57 44.23 2.48 65.24
116 INT204924 Negative_regulation of Clta 1 0.01 1.37 0 64.16
117 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 63.16
118 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 62.80
119 INT109450 Positive_regulation of Phosphorylation of AKT1 62 0.64 25.18 4.21 62.72
120 INT111477 Gene_expression of KRT7 90 0.74 86.76 4.07 62.28
121 INT36201 Gene_expression of ETFA 8 0.66 9.18 0.58 62.28
122 INT2037 Negative_regulation of EGF 30 0.59 15.05 6.81 61.76
123 INT44349 Gene_expression of FSIP1 5 0.77 6.56 2.54 58.84
124 INT112334 Regulation of NF1 18 0.52 15.85 0.34 55.04
125 INT89396 Phosphorylation of AKT1 225 0.82 111.66 19.61 54.48
126 INT96937 Gene_expression of Mmp9 191 0.75 150.3 56.01 53.60
127 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 50.00
128 INT81210 Positive_regulation of PRKG1 71 0.70 26.83 19.89 50.00
129 INT27739 Positive_regulation of EGF 49 0.70 28.31 13.68 50.00
130 INT94196 Negative_regulation of Phosphorylation of MAPK1 60 0.59 31.64 9.16 50.00
131 INT71785 Gene_expression of MAPK3 22 0.75 11.35 8.21 50.00
132 INT94197 Negative_regulation of Phosphorylation of MAPK3 13 0.57 5.51 6.18 50.00
133 INT87284 Negative_regulation of Positive_regulation of MAPK3 7 0.41 2.65 2.38 50.00
134 INT121657 Phosphorylation of IFI44 9 0.61 2.33 2.12 50.00
135 INT177933 Positive_regulation of MAP3K1 6 0.42 4.13 0.76 50.00
136 INT177941 Phosphorylation of MAP3K1 2 0.20 1.31 0.24 50.00
137 INT177944 Phosphorylation of CDK20 3 0.61 1.45 0.05 50.00
138 INT177932 Negative_regulation of Phosphorylation of CDK20 1 0.07 0.4 0 50.00
139 INT177942 Negative_regulation of Phosphorylation of IFI44 1 0.06 0.4 0 50.00
140 INT91445 Regulation of Bcl2 50 0.56 38.8 7.41 45.60
141 INT23955 Regulation of Vim 16 0.25 14.21 2.04 45.60
142 INT196003 Regulation of Cd34 4 0.30 3.38 0.5 45.60
143 INT96080 Regulation of UBE2D1 2 0.31 1.08 0.11 45.60
144 INT25123 Negative_regulation of COL7A1 42 0.58 19.98 5.96 42.48
145 INT131645 Negative_regulation of Nf1 10 0.58 8.12 1.24 41.36
146 INT671 Positive_regulation of Cea 221 0.69 164.5 47.79 39.08
147 INT68181 Binding of Nf1 6 0.48 8.14 1.88 38.52
148 INT6868 Gene_expression of GFAP 136 0.78 84.65 22.7 36.96
149 INT18897 Binding of CHGA 11 0.36 10.12 1.17 33.72
150 INT179133 Localization of Nf1 2 0.80 2.18 0.68 32.44
151 INT68179 Gene_expression of Nf1 9 0.78 8.87 0.68 31.16
152 INT225224 Positive_regulation of Nf2 1 0.59 3.4 0.12 27.04
153 INT225217 Positive_regulation of Positive_regulation of Nf2 1 0.43 1.07 0.04 27.04
154 INT225218 Positive_regulation of Negative_regulation of Nf2 1 0.40 1.07 0.04 27.04
155 INT225221 Negative_regulation of Nf2 1 0.57 18.06 0.83 26.40
156 INT175002 Positive_regulation of Mki67 10 0.31 5.7 0.26 19.04
157 INT97446 Localization of Mki67 9 0.46 3.74 0.46 16.88
158 INT74046 Localization of Calb2 12 0.80 2.05 2.24 15.52
159 INT135638 Binding of Dst 4 0.36 2.76 0.38 12.72
160 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 12.56
161 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73 11.44
162 INT82650 Gene_expression of Bcl2 312 0.78 211.71 55.03 5.00
163 INT25383 Gene_expression of Csf2 222 0.76 152.93 43.32 5.00
164 INT691 Binding of SST 67 0.48 24.66 32.67 5.00
165 INT7412 Positive_regulation of SST 71 0.70 24.44 29.48 5.00
166 INT86673 Positive_regulation of Bcl2 77 0.70 57.74 17.37 5.00
167 INT28420 Gene_expression of Ptgds 59 0.78 31.72 12.67 5.00
168 INT24876 Gene_expression of CD34 172 0.78 91.02 12.39 5.00
169 INT64346 Positive_regulation of S100B 95 0.70 63.11 9.17 5.00
170 INT158796 Positive_regulation of SMUG1 67 0.70 38.97 8.98 5.00
171 INT4991 Positive_regulation of Vim 74 0.69 69.84 8.33 5.00
172 INT84685 Regulation of BCL2 67 0.60 72.96 6.65 5.00
173 INT173967 Gene_expression of Mri1 26 0.43 16.67 6.45 5.00
174 INT92916 Gene_expression of Acta2 50 0.74 17.52 6.11 5.00
175 INT79425 Gene_expression of SMN1 42 0.65 36.37 6.1 5.00
176 INT100422 Negative_regulation of Gene_expression of Bcl2 46 0.58 28.86 5.7 5.00
177 INT60585 Regulation of TP53 59 0.59 54.55 5.21 5.00
178 INT140350 Binding of C2 17 0.36 3.97 4.69 5.00
179 INT56032 Positive_regulation of NCAM1 38 0.49 26.01 4.68 5.00
180 INT57749 Negative_regulation of Gene_expression of TP53 39 0.56 36.79 4.45 5.00
181 INT63113 Positive_regulation of HRAS 30 0.67 22.85 4.28 5.00
182 INT68269 Gene_expression of CD99 49 0.77 47.38 3.86 5.00
183 INT71602 Negative_regulation of Trp53 84 0.59 67.77 3.68 5.00
184 INT109403 Regulation of Gene_expression of BCL2 31 0.60 31.22 3.4 5.00
185 INT37590 Regulation of COL7A1 15 0.54 9.4 3.12 5.00
186 INT99961 Positive_regulation of SYP 13 0.67 15.13 2.79 5.00
187 INT23775 Regulation of S100B 24 0.62 16.75 2.57 5.00
188 INT204019 Negative_regulation of C2 10 0.26 6.23 2.44 5.00
189 INT15752 Positive_regulation of Ema 15 0.40 14.57 2.34 5.00
190 INT59784 Binding of DES 22 0.47 19.48 2.27 5.00
191 INT5844 Positive_regulation of Gene_expression of Vim 14 0.25 9.64 2.18 5.00
192 INT56817 Regulation of Eno2 16 0.61 10.64 1.99 5.00
193 INT105162 Gene_expression of Ad 47 0.12 46.53 1.83 5.00
194 INT95636 Gene_expression of ACTG2 23 0.44 19.87 1.75 5.00
195 INT167692 Binding of NCAM1 11 0.36 6.73 1.59 5.00
196 INT89445 Gene_expression of MEPE 17 0.58 18.07 1.55 5.00
197 INT76477 Positive_regulation of CD99 14 0.50 14.77 1.42 5.00
198 INT29635 Localization of Eno2 9 0.76 6.05 1.35 5.00
199 INT174156 Localization of Trp53 16 0.72 13.52 1.18 5.00
200 INT128987 Negative_regulation of Ccnd1 24 0.52 15.78 1.15 5.00
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