D:Nervous System Cancer

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Disease Term
Synonyms Cancer Of The Nervous Systems, Cancers Of The Nervous System, Neoplasm Nervous System, Neoplasm Of Nervous System, Neoplasms Nervous System, Nervous System Cancers, Nervous System Carcinoma, Nervous System Carcinomas, Nervous System Dysplasia, Nervous System Hyperplasia, NERVOUS SYSTEM NEOPLASIA
Documents 20
Hot Single Events 6
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Nervous System Cancer. They are ordered first by their relevance to Nervous System Cancer and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT330379 Gene_expression of IL10 Negative_regulation of Positive_regulation of MAPK14 1 0.00 1.95 1.18 5.00
2 INT330377 Positive_regulation of Binding of TLR2 and TLR9 1 0.09 2.79 0.32 5.00
3 INT330381 Binding of TLR2 and TLR9 1 0.07 2.77 0.32 5.00
4 INT330389 Positive_regulation of Binding of TLR2 and TLR8 1 0.08 2.78 0.32 5.00
5 INT330383 Binding of TLR2 and TLR3 1 0.07 2.77 0.31 5.00
6 INT330378 Positive_regulation of Binding of TLR2 and TLR3 1 0.10 2.78 0.31 5.00
7 INT330387 Binding of TLR2 and TLR8 1 0.06 2.77 0.31 5.00
8 INT330382 IFNA1 Positive_regulation of Gene_expression of IL10 1 0.06 0.83 0.21 5.00
9 INT330371 Binding of TLR3 and Ifx 1 0.17 1.12 0.2 5.00
10 INT330388 Binding of PTPRC and TLR2 1 0.00 1.19 0.16 5.00
11 INT330370 Positive_regulation of Binding of IL10 and Il4 1 0.01 0.47 0.13 5.00
12 INT330369 Binding of IL10 and Il4 1 0.01 0.47 0.13 5.00
13 INT330380 CD40 Regulation of Gene_expression of IFNA1 1 0.17 0.78 0.1 5.00
14 INT330372 Ifx Positive_regulation of IFNA1 1 0.54 0.67 0.04 5.00
15 INT213903 Binding of EGFR and ERBB2 10 0.37 5.03 0.04 5.00
16 INT307586 Binding of EGFR and CDCP1 1 0.01 0.51 0 5.00
17 INT307585 Binding of EGFR and MET 1 0.11 0.52 0 5.00
18 INT330384 IER3 Regulation of USH2A 1 0.00 0.87 0 5.00
19 INT307584 Binding of EGFR and IGF1R 1 0.03 0.52 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Nervous System Cancer. They are ordered first by their pain relevance and then by number of times they were reported in Nervous System Cancer. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT68216 Binding of NF1 40 0.48 51.24 4.59 99.66
2 INT144231 Gene_expression of Il12b 18 0.75 12.93 3.65 99.36
3 INT164841 Gene_expression of Nf2 3 0.67 1.23 0 97.48
4 INT133293 Positive_regulation of Nf2 3 0.49 1.67 0.27 97.48
5 INT117660 Gene_expression of Prom1 50 0.73 39.62 3.07 94.28
6 INT90 Localization of Gast 400 0.81 137.67 113 81.60
7 INT351538 Binding of Prom1 8 0.38 4.44 0.49 77.92
8 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 73.32
9 INT8095 Gene_expression of ERBB3 47 0.77 24.85 2.82 70.60
10 INT9783 Gene_expression of INSRR 81 0.50 32.99 15.52 64.04
11 INT51149 Positive_regulation of Gene_expression of INSRR 5 0.17 2.94 1.86 64.04
12 INT8098 Positive_regulation of Gene_expression of ERBB3 7 0.69 3.79 0.1 64.04
13 INT91702 Negative_regulation of GIF 4 0.42 1.58 0.08 56.12
14 INT22301 Positive_regulation of Gene_expression of CSF2 66 0.63 59.49 14.24 41.92
15 INT6810 Gene_expression of ENO2 70 0.78 54.8 8.35 38.96
16 INT188588 Localization of Mthfd1 20 0.49 9.19 4.37 33.60
17 INT294675 Localization of Il12b 2 0.78 1.15 0.19 32.88
18 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 18.56
19 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 18.36
20 INT27933 Gene_expression of NCOR2 65 0.72 31.35 24.23 17.28
21 INT102234 Gene_expression of ESR2 17 0.65 9.29 2.3 17.28
22 INT73252 Positive_regulation of Mthfd1 124 0.59 59.48 18.35 16.24
23 INT142435 Gene_expression of NES 86 0.78 47.53 4.92 9.52
24 INT11158 Positive_regulation of Gene_expression of EGFR 165 0.70 131.26 4.93 9.04
25 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
26 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 5.00
27 INT20374 Gene_expression of Il4 515 0.76 306.15 114.12 5.00
28 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 5.00
29 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
30 INT65500 Gene_expression of App 605 0.78 429.94 98.31 5.00
31 INT96917 Positive_regulation of Mapk14 261 0.70 173.29 88.79 5.00
32 INT914 Positive_regulation of GH1 292 0.69 100.7 84.91 5.00
33 INT75999 Gene_expression of BDNF 344 0.78 114.19 83.12 5.00
34 INT2289 Gene_expression of PENK 203 0.78 55.62 79.49 5.00
35 INT62374 Gene_expression of NGF 158 0.78 77.87 76.45 5.00
36 INT170332 Gene_expression of IFN1@ 477 0.75 275.21 69.65 5.00
37 INT5058 Positive_regulation of IFNA1 356 0.70 245.75 60.52 5.00
38 INT20382 Gene_expression of Hand2 211 0.66 142.26 51.05 5.00
39 INT531 Gene_expression of GH1 376 0.75 193.45 46.24 5.00
40 INT42980 Gene_expression of GAD1 139 0.69 94.77 45.11 5.00
41 INT6979 Positive_regulation of CA2 206 0.67 50.79 44.97 5.00
42 INT18522 Positive_regulation of Gene_expression of IFNA1 248 0.67 160.85 44.87 5.00
43 INT1726 Positive_regulation of Kitl 65 0.70 38.81 44.85 5.00
44 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 5.00
45 INT25383 Gene_expression of Csf2 222 0.76 152.93 43.32 5.00
46 INT89 Positive_regulation of Gast 187 0.70 80.49 42.07 5.00
47 INT133028 Gene_expression of TLR2 209 0.73 131.92 36.17 5.00
48 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 5.00
49 INT49214 Gene_expression of Cd4 269 0.78 154.22 34.05 5.00
50 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98 5.00
51 INT11325 Gene_expression of HLA-E 209 0.76 98.05 33.72 5.00
52 INT5489 Localization of CA2 172 0.80 39.46 33.56 5.00
53 INT29743 Negative_regulation of App 91 0.59 65.56 31.26 5.00
54 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73 5.00
55 INT110020 Gene_expression of Mapk14 142 0.77 72.33 30.08 5.00
56 INT21900 Gene_expression of Mthfd1 150 0.75 69.47 27.03 5.00
57 INT19856 Gene_expression of CD8A 240 0.75 147.86 26.39 5.00
58 INT70048 Positive_regulation of Gene_expression of IL10 90 0.55 71.34 25.66 5.00
59 INT89662 Positive_regulation of Gene_expression of App 169 0.70 133.36 25.62 5.00
60 INT29 Negative_regulation of Gast 74 0.59 24.85 24.96 5.00
61 INT58192 Positive_regulation of MRI1 86 0.61 53.81 24.68 5.00
62 INT22708 Gene_expression of MUC1 297 0.78 232.71 24.19 5.00
63 INT86534 Positive_regulation of MAPK14 81 0.62 57.81 23.62 5.00
64 INT74423 Localization of IL10 91 0.80 61.6 22.95 5.00
65 INT6868 Gene_expression of GFAP 136 0.78 84.65 22.7 5.00
66 INT62373 Negative_regulation of NGF 34 0.59 25.87 22.38 5.00
67 INT171924 Gene_expression of MAPK14 60 0.65 54.38 21.68 5.00
68 INT116856 Gene_expression of TNFSF10 110 0.75 115.76 21.48 5.00
69 INT137767 Gene_expression of Eae1 74 0.34 89.32 20.48 5.00
70 INT14701 Negative_regulation of IFNA1 118 0.54 84.19 20.08 5.00
71 INT20129 Regulation of Il1 53 0.53 44.14 19.89 5.00
72 INT65502 Regulation of App 77 0.62 52.05 19.44 5.00
73 INT18311 Positive_regulation of CD8A 145 0.69 113.48 19.44 5.00
74 INT192409 Positive_regulation of Gene_expression of IFN1@ 102 0.67 64.66 18.8 5.00
75 INT7056 Positive_regulation of Gene_expression of PENK 35 0.70 14.31 18.21 5.00
76 INT33542 Gene_expression of Il1rn 41 0.76 32.47 18.08 5.00
77 INT112017 Regulation of Hand2 77 0.36 62.23 18.04 5.00
78 INT168263 Gene_expression of IL23A 57 0.58 47.1 17.67 5.00
79 INT13510 Gene_expression of ERBB2 530 0.78 405.68 16.79 5.00
80 INT84924 Positive_regulation of Gene_expression of NGF 29 0.68 17.91 16.46 5.00
81 INT22900 Positive_regulation of Cd4 126 0.67 82.77 16.43 5.00
82 INT10214 Gene_expression of VIM 153 0.78 115.88 16.29 5.00
83 INT104045 Regulation of Hand1 65 0.35 51.32 16.26 5.00
84 INT97871 Gene_expression of Ntf3 47 0.78 25.9 15.94 5.00
85 INT9220 Gene_expression of Ighg1 125 0.77 85.74 15.92 5.00
86 INT171666 Regulation of GOPC 117 0.39 40.41 15.47 5.00
87 INT170335 Gene_expression of INCENP 176 0.54 91.62 15.31 5.00
88 INT72127 Protein_catabolism of MMRN1 68 0.52 56 14.13 5.00
89 INT18012 Gene_expression of EPO 169 0.78 108.36 13.75 5.00
90 INT69029 Gene_expression of PTPRC 127 0.75 74.26 11.57 5.00
91 INT27651 Gene_expression of S100A12 45 0.76 52.25 10.51 5.00
92 INT85048 Regulation of NGF 19 0.62 11.61 10.5 5.00
93 INT150540 Binding of TLR2 50 0.45 35.86 10.43 5.00
94 INT33099 Negative_regulation of INSRR 32 0.40 13.82 9.85 5.00
95 INT21952 Gene_expression of GDNF 42 0.78 20.32 9.62 5.00
96 INT21214 Negative_regulation of Gene_expression of PENK 21 0.58 9.14 9.53 5.00
97 INT57549 Gene_expression of GNPTAB 49 0.65 57.5 9.05 5.00
98 INT182137 Gene_expression of TLR9 137 0.78 48.48 9.05 5.00
99 INT173587 Protein_catabolism of COL5A2 59 0.32 32.73 8.96 5.00
100 INT61264 Regulation of Jun 36 0.61 18.42 8.71 5.00
101 INT59165 Binding of fc 67 0.36 37.51 8.68 5.00
102 INT25392 Positive_regulation of Gene_expression of Csf2 41 0.49 34.28 8.36 5.00
103 INT92680 Gene_expression of Fgf2 59 0.77 28.11 8.12 5.00
104 INT97870 Positive_regulation of Gene_expression of Ntf3 19 0.70 9.56 7.8 5.00
105 INT1664 Gene_expression of Kitl 30 0.65 13.63 7.47 5.00
106 INT51741 Regulation of Gene_expression of Il4 23 0.36 12.7 7.39 5.00
107 INT50212 Gene_expression of Ifx 33 0.75 32.17 7.26 5.00
108 INT63373 Negative_regulation of Gene_expression of NGF 14 0.57 8.9 7.1 5.00
109 INT137206 Positive_regulation of TLR2 47 0.65 33.36 6.4 5.00
110 INT11154 Binding of EGFR 149 0.48 96.23 6.29 5.00
111 INT56160 Binding of Ifx 14 0.36 11.39 5.74 5.00
112 INT187133 Protein_catabolism of TIMP1 19 0.73 11.3 5.51 5.00
113 INT15376 Positive_regulation of Gene_expression of ERBB2 215 0.70 168.54 5.23 5.00
114 INT126751 Regulation of Gene_expression of IL10 16 0.44 10.84 5.22 5.00
115 INT15849 Gene_expression of FRTS 27 0.58 7.14 5.14 5.00
116 INT175312 Positive_regulation of Gene_expression of IL23A 17 0.45 14.8 5.05 5.00
117 INT105393 Positive_regulation of Localization of VEGFA 66 0.70 45.45 4.9 5.00
118 INT130290 Positive_regulation of Localization of IL10 16 0.47 9.38 4.75 5.00
119 INT137178 Gene_expression of TLR3 46 0.72 24.97 4.33 5.00
120 INT1209 Binding of Kitl 14 0.37 6.72 4.3 5.00
121 INT204529 Positive_regulation of TLR9 18 0.62 15.62 3.99 5.00
122 INT65072 Gene_expression of TKT 16 0.65 17.58 3.55 5.00
123 INT5609 Regulation of Ifx 6 0.60 5.73 3.5 5.00
124 INT66585 Gene_expression of IER3 13 0.63 7.39 3.48 5.00
125 INT101068 Negative_regulation of CDCP1 27 0.03 17.67 3.45 5.00
126 INT79270 Gene_expression of MKI67 113 0.77 63.52 3.38 5.00
127 INT178631 Phosphorylation of ESR1 21 0.75 9.16 3.36 5.00
128 INT154334 Localization of S100A12 9 0.80 9.32 2.89 5.00
129 INT47011 Positive_regulation of Gusb 14 0.44 8.93 2.87 5.00
130 INT188590 Positive_regulation of Gene_expression of Mthfd1 23 0.49 16.56 2.84 5.00
131 INT78248 Negative_regulation of Cdkn2a 17 0.59 15.15 2.8 5.00
132 INT204524 Binding of TLR9 17 0.43 11.69 2.76 5.00
133 INT75685 Regulation of CD86 12 0.58 3.55 2.66 5.00
134 INT90875 Negative_regulation of CCND1 31 0.42 26.22 2.66 5.00
135 INT133029 Regulation of TLR2 18 0.56 11.31 2.62 5.00
136 INT36338 Gene_expression of NRP2 29 0.67 6.47 2.4 5.00
137 INT105761 Binding of GFAP 13 0.36 14.94 2.32 5.00
138 INT313711 Gene_expression of Pet1 4 0.76 1.91 2.29 5.00
139 INT181015 Gene_expression of C3ar1 12 0.58 8.9 2.18 5.00
140 INT89253 Regulation of Mthfd1 14 0.23 8.1 1.94 5.00
141 INT184006 Gene_expression of Ighg2b 21 0.71 7.97 1.86 5.00
142 INT23148 Gene_expression of RUNX1 10 0.10 6.58 1.71 5.00
143 INT165213 Regulation of Gene_expression of Cd4 12 0.40 9.14 1.57 5.00
144 INT14514 Regulation of FRTS 10 0.44 2.39 1.56 5.00
145 INT60162 Gene_expression of Ie 41 0.58 23.77 1.52 5.00
146 INT83429 Binding of FRTS 8 0.42 5.46 1.52 5.00
147 INT3164 Positive_regulation of GUSB 4 0.49 2.67 1.47 5.00
148 INT27762 Positive_regulation of Gene_expression of EPO 18 0.70 17.67 1.45 5.00
149 INT51486 Negative_regulation of GNPTAB 11 0.41 8.18 1.45 5.00
150 INT53929 Positive_regulation of GNPTAB 12 0.32 6.66 1.4 5.00
151 INT175636 Positive_regulation of Protein_catabolism of MMRN1 8 0.30 11.38 1.39 5.00
152 INT186810 Positive_regulation of TLR3 13 0.65 6.37 1.37 5.00
153 INT67133 Gene_expression of Gusb 14 0.75 18.57 1.37 5.00
154 INT53198 Positive_regulation of Positive_regulation of Cd4 6 0.49 3.75 1.36 5.00
155 INT79358 Gene_expression of ERVW-1 65 0.75 29.9 1.31 5.00
156 INT74254 Binding of PTPRC 16 0.36 8.37 1.27 5.00
157 INT61993 Gene_expression of NF1 29 0.78 34.47 1.23 5.00
158 INT127900 Phosphorylation of EIF2AK3 14 0.80 7.99 1.22 5.00
159 INT154333 Positive_regulation of Localization of S100A12 4 0.69 3.9 1.19 5.00
160 INT88568 Positive_regulation of RRM1 4 0.41 1.81 1.14 5.00
161 INT134661 Negative_regulation of Tp53 11 0.43 10.91 1.13 5.00
162 INT60286 Gene_expression of PKLR 5 0.65 2.14 1.04 5.00
163 INT178483 Gene_expression of Col18a1 12 0.75 11.87 1.03 5.00
164 INT58692 Regulation of Gene_expression of CD8A 11 0.42 10.16 1 5.00
165 INT231560 Negative_regulation of Gene_expression of IL23A 3 0.11 2.41 0.99 5.00
166 INT147088 Gene_expression of HHEX 5 0.65 4.86 0.99 5.00
167 INT177587 Regulation of Gene_expression of MRI1 4 0.22 0.88 0.97 5.00
168 INT56151 Positive_regulation of Positive_regulation of CD8A 11 0.34 9.74 0.94 5.00
169 INT60728 Gene_expression of Serpinb1-ps1 10 0.59 6.92 0.93 5.00
170 INT51262 Positive_regulation of TKT 7 0.69 4.31 0.82 5.00
171 INT186804 Binding of TLR3 14 0.45 8.41 0.79 5.00
172 INT120693 Positive_regulation of MEPE 7 0.50 8.22 0.79 5.00
173 INT114625 Gene_expression of KPNB1 5 0.42 0.87 0.72 5.00
174 INT157073 Positive_regulation of PKLR 6 0.36 5.48 0.69 5.00
175 INT330333 Gene_expression of Lap2 1 0.17 1.57 0.69 5.00
176 INT322032 Binding of TLR8 3 0.32 2.57 0.69 5.00
177 INT236320 Regulation of HLA-DRB1 10 0.45 6 0.69 5.00
178 INT186801 Positive_regulation of Binding of TLR2 3 0.42 2.05 0.67 5.00
179 INT136531 Binding of Men1 8 0.47 9.62 0.65 5.00
180 INT139078 Gene_expression of Tnip1 2 0.51 1.93 0.64 5.00
181 INT330363 Positive_regulation of Gene_expression of HHEX 1 0.11 1.71 0.62 5.00
182 INT213410 Localization of TKT 3 0.71 1.89 0.61 5.00
183 INT185244 Gene_expression of Sox2 27 0.65 4.71 0.61 5.00
184 INT185240 Binding of Fgf2 14 0.37 7.39 0.59 5.00
185 INT60289 Negative_regulation of PKLR 5 0.21 1.75 0.53 5.00
186 INT188724 Gene_expression of IGLV3-1 29 0.75 20.88 0.51 5.00
187 INT330393 Positive_regulation of Gene_expression of Il12b 2 0.49 1.24 0.48 5.00
188 INT173968 Regulation of Gene_expression of Ifx 2 0.60 1.77 0.48 5.00
189 INT351536 Positive_regulation of Gene_expression of Pet1 2 0.49 1.2 0.47 5.00
190 INT79841 Binding of ITGAM 6 0.47 1.37 0.47 5.00
191 INT238502 Regulation of CD40 6 0.28 3.7 0.44 5.00
192 INT98072 Gene_expression of LAT 5 0.68 5.37 0.44 5.00
193 INT192806 Binding of SSRP1 11 0.27 9.12 0.37 5.00
194 INT179532 Protein_catabolism of C3 5 0.26 1.61 0.34 5.00
195 INT207897 Positive_regulation of TLR8 3 0.17 2.52 0.33 5.00
196 INT299643 Negative_regulation of Binding of fc 4 0.08 1.82 0.33 5.00
197 INT298355 Regulation of CD83 5 0.24 2.98 0.32 5.00
198 INT228433 Negative_regulation of Gene_expression of TKT 2 0.35 1.13 0.32 5.00
199 INT192226 Gene_expression of BAI1 4 0.26 2.99 0.3 5.00
200 INT330334 Localization of Ifx 1 0.73 1.36 0.29 5.00
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