D:Neurocutaneous Syndromes

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pChart

Disease Term
Synonyms Neurocutaneous Disorder, Neurocutaneous Disorders, NEUROCUTANEOUS SYNDROME, Neuroectodermal Dysplasia Syndrome, Neuroectodermal Dysplasia Syndromes, Phacomatoses, PHACOMATOSIS, Phakomatoses, Phakomatosis, Syndrome Neurocutaneous, Syndrome Neuroectodermal Dysplasia
Documents 44
Hot Single Events 10
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Neurocutaneous Syndromes. They are ordered first by their relevance to Neurocutaneous Syndromes and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT266839 Fgf23 Negative_regulation of Slc34a1 1 0.21 0.88 0 28.60
2 INT331628 Binding of HLA-DQA2 and Pain1 1 0.01 2.13 0.14 5.00
3 INT331627 Binding of HLA-DRB3 and Pain1 1 0.00 2.15 0.14 5.00
4 INT331612 ETV4 Positive_regulation of Gene_expression of TGFB1 1 0.00 1.32 0.12 5.00
5 INT331626 Edn1 Positive_regulation of Itk 1 0.00 0.57 0.07 5.00
6 INT331629 Binding of TGFB1 and Positive_regulation of Gene_expression of Itk 1 0.00 0.84 0.07 5.00
7 INT331611 NKX2-1 Regulation of Transcription of SFTPB 1 0.01 0.49 0 5.00
8 INT266837 Dmp1 Negative_regulation of Gene_expression of Fgf23 1 0.48 2.41 0 5.00
9 INT266835 Pth Regulation of Slc34a3 1 0.19 0.07 0 5.00
10 INT266836 Pth Regulation of Slc34a1 1 0.09 0.07 0 5.00
11 INT266834 Pth Negative_regulation of Positive_regulation of Grxcr1 1 0.04 0.51 0 5.00
12 INT266833 Phex Regulation of Gene_expression of Fgf23 1 0.23 0.46 0 5.00
13 INT266838 Fgf23 Regulation of Slc34a1 1 0.13 0.3 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Neurocutaneous Syndromes. They are ordered first by their pain relevance and then by number of times they were reported in Neurocutaneous Syndromes. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT68216 Binding of NF1 40 0.48 51.24 4.59 99.32
2 INT214073 Binding of TSC1 9 0.37 22 1.34 95.76
3 INT36200 Gene_expression of S100A1 9 0.77 9.56 0.75 93.28
4 INT425 Localization of PRL 455 0.81 189.64 144.8 92.96
5 INT118373 Gene_expression of Fgf23 16 0.77 29.62 1.04 92.76
6 INT90 Localization of Gast 400 0.81 137.67 113 91.52
7 INT6511 Positive_regulation of AFP 76 0.70 70.15 7.28 86.40
8 INT266830 Regulation of Slc34a3 1 0.42 1.85 0 83.20
9 INT266831 Positive_regulation of Slc34a3 1 0.47 1.79 0 81.92
10 INT6810 Gene_expression of ENO2 70 0.78 54.8 8.35 80.28
11 INT29 Negative_regulation of Gast 74 0.59 24.85 24.96 65.96
12 INT22413 Positive_regulation of Cyp39a1 2 0.08 2.49 0.09 58.72
13 INT915 Positive_regulation of PRL 342 0.70 141.96 104.31 53.20
14 INT22500 Negative_regulation of Pth 6 0.43 3.41 2.83 51.04
15 INT266819 Regulation of Localization of Grxcr1 2 0.06 1.28 0 24.88
16 INT266818 Localization of Grxcr1 7 0.12 3.9 0 24.52
17 INT70263 Negative_regulation of Cyp39a1 2 0.05 0.96 0 23.72
18 INT266823 Regulation of Grxcr1 3 0.06 1.4 0.03 18.28
19 INT266828 Negative_regulation of Fgf23 3 0.42 5.63 0.04 15.92
20 INT146139 Gene_expression of ETV4 11 0.12 8.43 0.11 9.36
21 INT118371 Positive_regulation of Fgf23 15 0.69 25.34 0.85 7.60
22 INT135880 Positive_regulation of Gene_expression of Fgf23 4 0.46 7.52 0.29 7.60
23 INT118372 Regulation of Fgf23 4 0.55 3.31 0.15 6.56
24 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 5.00
25 INT1893 Localization of Gh 1041 0.79 340.23 256.58 5.00
26 INT738 Regulation of POMC 459 0.62 111.19 243.74 5.00
27 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
28 INT6354 Localization of Gabrg1 321 0.74 41.41 186.74 5.00
29 INT14843 Gene_expression of Gabrg1 301 0.77 62.63 139.16 5.00
30 INT695 Binding of POMC 304 0.48 56.66 126.85 5.00
31 INT6323 Positive_regulation of Gabrg1 213 0.70 45.08 124.34 5.00
32 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 5.00
33 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 5.00
34 INT14740 Gene_expression of TGFB1 272 0.78 168.48 60.18 5.00
35 INT5016 Negative_regulation of Crh 129 0.59 36.74 59.28 5.00
36 INT42980 Gene_expression of GAD1 139 0.69 94.77 45.11 5.00
37 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 5.00
38 INT89 Positive_regulation of Gast 187 0.70 80.49 42.07 5.00
39 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 5.00
40 INT6357 Positive_regulation of Localization of Gabrg1 53 0.41 7.03 39.21 5.00
41 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98 5.00
42 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 5.00
43 INT6364 Gene_expression of Edn1 123 0.78 73.76 28.43 5.00
44 INT14690 Localization of CSF2 124 0.80 85.17 27.26 5.00
45 INT58192 Positive_regulation of MRI1 86 0.61 53.81 24.68 5.00
46 INT14731 Positive_regulation of TGFB1 78 0.67 52.57 22.23 5.00
47 INT14733 Positive_regulation of Gene_expression of TGFB1 71 0.69 49.89 22.2 5.00
48 INT18311 Positive_regulation of CD8A 145 0.69 113.48 19.44 5.00
49 INT33327 Positive_regulation of Gene_expression of Gabrg1 39 0.69 9.68 18.82 5.00
50 INT28215 Gene_expression of CDKN1A 196 0.76 113.9 18.3 5.00
51 INT12081 Localization of TGFB1 64 0.81 35.4 17.47 5.00
52 INT22900 Positive_regulation of Cd4 126 0.67 82.77 16.43 5.00
53 INT10214 Gene_expression of VIM 153 0.78 115.88 16.29 5.00
54 INT11685 Regulation of CSF2 99 0.59 58.82 15.9 5.00
55 INT75502 Positive_regulation of CDKN1A 123 0.68 70.75 14.74 5.00
56 INT6947 Negative_regulation of Gene_expression of POMC 37 0.59 10.32 14.14 5.00
57 INT10016 Negative_regulation of CD8A 81 0.42 56.68 13.15 5.00
58 INT11288 Negative_regulation of CRH 44 0.00 16.69 12.37 5.00
59 INT107033 Gene_expression of Slc37a4 66 0.62 27.34 12.35 5.00
60 INT10009 Positive_regulation of TRH 31 0.67 8.94 11.03 5.00
61 INT57162 Positive_regulation of Gene_expression of CDKN1A 64 0.68 35.3 9.69 5.00
62 INT132586 Negative_regulation of Hand2 40 0.30 26.58 9.28 5.00
63 INT19185 Negative_regulation of Cd4 80 0.51 61.32 8.51 5.00
64 INT13085 Positive_regulation of ACE 50 0.70 44.2 8.31 5.00
65 INT92916 Gene_expression of Acta2 50 0.74 17.52 6.11 5.00
66 INT69350 Gene_expression of RAC1 23 0.77 12.16 5.54 5.00
67 INT89104 Binding of TGFB1 29 0.44 13.67 5.12 5.00
68 INT120073 Positive_regulation of Itk 34 0.44 23.45 5.09 5.00
69 INT2725 Positive_regulation of FCER2 23 0.69 23.08 4.7 5.00
70 INT89103 Regulation of Gene_expression of TGFB1 15 0.56 8.11 4.37 5.00
71 INT12083 Regulation of TGFB1 22 0.53 15.4 3.6 5.00
72 INT79270 Gene_expression of MKI67 113 0.77 63.52 3.38 5.00
73 INT55002 Gene_expression of ASAP1 46 0.64 22.8 3.2 5.00
74 INT38013 Gene_expression of Casr 30 0.73 6.03 3.09 5.00
75 INT136964 Gene_expression of Dmp1 10 0.75 3.69 2.83 5.00
76 INT32421 Gene_expression of FCER2 19 0.73 17.23 2.53 5.00
77 INT70987 Binding of RAC1 14 0.37 12.14 2.13 5.00
78 INT83896 Gene_expression of CD1A 19 0.68 15.58 2.1 5.00
79 INT158442 Gene_expression of Nkx2-1 21 0.59 8.47 1.99 5.00
80 INT113147 Positive_regulation of Acta2 6 0.34 4.24 1.66 5.00
81 INT120075 Gene_expression of Itk 11 0.43 6.39 1.27 5.00
82 INT15040 Gene_expression of NKX2-1 8 0.65 3.95 1.02 5.00
83 INT23030 Positive_regulation of Pth 13 0.61 9.24 0.97 5.00
84 INT177587 Regulation of Gene_expression of MRI1 4 0.22 0.88 0.97 5.00
85 INT169706 Positive_regulation of Gene_expression of Itk 2 0.32 2.08 0.81 5.00
86 INT120693 Positive_regulation of MEPE 7 0.50 8.22 0.79 5.00
87 INT16003 Gene_expression of Phex 3 0.65 4.68 0.77 5.00
88 INT114909 Negative_regulation of Localization of TGFB1 5 0.36 1.37 0.66 5.00
89 INT136531 Binding of Men1 8 0.47 9.62 0.65 5.00
90 INT66193 Negative_regulation of Btd 3 0.59 3.39 0.32 5.00
91 INT186450 Negative_regulation of SFTPB 17 0.58 10.94 0.31 5.00
92 INT317746 Positive_regulation of Gene_expression of FCER2 2 0.01 4.09 0.3 5.00
93 INT125804 Localization of Pth 9 0.69 3.93 0.29 5.00
94 INT166125 Gene_expression of PHOSPHO1 4 0.75 3.06 0.24 5.00
95 INT299545 Positive_regulation of Binding of TGFB1 2 0.06 1.08 0.22 5.00
96 INT130802 Localization of FGF23 2 0.17 1.78 0.2 5.00
97 INT266832 Positive_regulation of Grxcr1 9 0.12 7.91 0.19 5.00
98 INT239883 Transcription of SFTPC 3 0.69 1.11 0.18 5.00
99 INT228901 Positive_regulation of RPS6KB1 5 0.55 2.44 0.18 5.00
100 INT266822 Negative_regulation of Grxcr1 10 0.10 8.12 0.17 5.00
101 INT192842 Binding of Hspa5 3 0.33 1.48 0.16 5.00
102 INT231230 Localization of SFTPC 2 0.68 2.06 0.16 5.00
103 INT167957 Gene_expression of Grxcr1 8 0.10 3.43 0.14 5.00
104 INT228902 Gene_expression of RPS6KB1 5 0.75 2.32 0.1 5.00
105 INT320983 Negative_regulation of Localization of Pth 2 0.38 1.17 0.09 5.00
106 INT117827 Positive_regulation of PHEX 3 0.41 1.59 0.08 5.00
107 INT331623 Negative_regulation of Binding of TGFB1 1 0.02 1.02 0.08 5.00
108 INT266826 Binding of Fgf23 1 0.32 1.26 0.07 5.00
109 INT331613 Regulation of Positive_regulation of Itk 1 0.02 0.87 0.06 5.00
110 INT266821 Positive_regulation of Negative_regulation of Grxcr1 1 0.06 1.51 0.06 5.00
111 INT266820 Positive_regulation of Positive_regulation of Grxcr1 1 0.06 1.58 0.06 5.00
112 INT331615 Binding of Igbp1 1 0.00 0.95 0.05 5.00
113 INT191542 Binding of ABCA3 1 0.22 1.61 0.03 5.00
114 INT228904 Positive_regulation of PHOSPHO1 1 0.45 0.84 0 5.00
115 INT202316 Gene_expression of SCGB3A1 1 0.11 1.62 0 5.00
116 INT266824 Regulation of Positive_regulation of Fgf23 1 0.27 1.22 0 5.00
117 INT228895 Binding of Tsc2 5 0.30 2.41 0 5.00
118 INT228899 Positive_regulation of Gene_expression of PHOSPHO1 1 0.49 0.84 0 5.00
119 INT266829 Regulation of Cyp39a1 1 0.02 0.44 0 5.00
120 INT228900 Positive_regulation of Gene_expression of RPS6KB1 2 0.49 1.6 0 5.00
121 INT266827 Positive_regulation of Mepe 1 0.67 1.25 0 5.00
122 INT331624 Transcription of SFTPB 1 0.03 0.48 0 5.00
123 INT266825 Positive_regulation of Regulation of Fgf23 1 0.46 0.25 0 5.00
124 INT228903 Negative_regulation of Gene_expression of PHOSPHO1 1 0.42 0.79 0 5.00
125 INT331625 Negative_regulation of ABCA3 1 0.27 0.38 0 5.00
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