D:Neurofibroma

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Disease Term
Synonyms NEUROFIBROMAS
Documents 268
Hot Single Events 48
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Neurofibroma. They are ordered first by their relevance to Neurofibroma and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT103197 Nf1 Negative_regulation of ras 1 0.04 1.19 0.17 87.28
2 INT103198 NF1 Negative_regulation of ras 1 0.05 1.19 0.16 87.28
3 INT191612 Nf1 Positive_regulation of ras 1 0.25 2.6 0.11 48.72
4 INT191614 Adcyap1 Positive_regulation of Rtcd1 1 0.01 0.93 0 25.80
5 INT191618 Binding of App and Nf1 1 0.35 3.77 1.65 5.00
6 INT191610 Binding of App and Drd3 1 0.20 0.7 0.42 5.00
7 INT191616 Binding of Cbln1 and Nf1 1 0.01 0.2 0.32 5.00
8 INT191620 Binding of Nf1 and Gopc 1 0.08 0.2 0.32 5.00
9 INT191611 Nf1 Regulation of ras 1 0.26 0.18 0.3 5.00
10 INT190052 Binding of Cdx2 and Ebp 1 0.08 0.82 0.24 5.00
11 INT191619 Binding of App and Flna 1 0.04 0.18 0.24 5.00
12 INT190045 Binding of Ebp and Scrib 1 0.10 0.79 0.22 5.00
13 INT191609 Binding of Drd3 and Flna 1 0.06 0.42 0.17 5.00
14 INT191615 Binding of Nf1 and Flna 1 0.08 0.53 0.17 5.00
15 INT191621 Binding of Drd3 and Nf1 1 0.32 0.53 0.17 5.00
16 INT191617 Binding of Nf1 and Rtcd1 1 0.01 0.95 0.08 5.00
17 INT352297 Regulation of Binding of CD99 and VIM 1 0.19 1.07 0.06 5.00
18 INT352296 Binding of CD99 and VIM 1 0.16 1.06 0.06 5.00
19 INT352299 Regulation of Binding of BCL2 and VIM 1 0.10 1.07 0.06 5.00
20 INT352298 Binding of BCL2 and VIM 1 0.09 1.06 0.06 5.00
21 INT190044 Binding of Msh2 and Msh6 2 0.32 0.77 0.05 5.00
22 INT190050 Binding of Msh2 and Pms2 2 0.32 0.49 0.04 5.00
23 INT190046 Binding of Msh3 and Pms2 2 0.25 0.5 0.04 5.00
24 INT191613 Binding of Nf1 and Rasa1 1 0.06 0.88 0.03 5.00
25 INT190061 Binding of MLH1 and Mlh1 1 0.01 0.92 0 5.00
26 INT234612 Binding of KIT and STIP1 1 0.04 1 0 5.00
27 INT190049 Binding of Mlh1 and Msh3 1 0.24 0.22 0 5.00
28 INT190048 Binding of Mlh1 and Msh2 1 0.31 0.22 0 5.00
29 INT242102 Nkx2-1 Regulation of Gene_expression of Ttf1 1 0.00 1.55 0 5.00
30 INT190062 Binding of MLH1 and Msh2 1 0.01 0.91 0 5.00
31 INT190047 Binding of Msh2 and Msh3 1 0.24 0.23 0 5.00
32 INT300631 Binding of TSC1 and TSC2 1 0.15 2.59 0 5.00
33 INT190051 Binding of Ebp and Mrc1 1 0.04 0.63 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Neurofibroma. They are ordered first by their pain relevance and then by number of times they were reported in Neurofibroma. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT64700 Binding of Nf1 14 0.45 15.24 2.29 100.00
2 INT49650 Gene_expression of Nf1 4 0.76 3.38 0.67 99.98
3 INT68216 Binding of NF1 40 0.48 51.24 4.59 99.92
4 INT61993 Gene_expression of NF1 29 0.78 34.47 1.23 99.84
5 INT61991 Negative_regulation of Gene_expression of NF1 1 0.59 1.67 0.08 99.54
6 INT35011 Gene_expression of PPFIBP1 3 0.48 4.52 0.08 99.42
7 INT35010 Gene_expression of CCT8 1 0.08 1.12 0.08 99.42
8 INT61992 Positive_regulation of Gene_expression of NF1 3 0.50 4.47 0.51 98.58
9 INT112334 Regulation of NF1 18 0.52 15.85 0.34 96.88
10 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 96.88
11 INT69264 Gene_expression of KIT 207 0.78 179.41 8.95 96.88
12 INT109327 Negative_regulation of KIT 42 0.57 43.2 2.15 96.60
13 INT47916 Positive_regulation of RIMS1 2 0.67 2.03 1.03 96.56
14 INT63113 Positive_regulation of HRAS 30 0.67 22.85 4.28 96.16
15 INT5842 Gene_expression of Gfap 372 0.78 153.71 127.71 95.88
16 INT62684 Negative_regulation of TP53 66 0.58 66.09 4.62 95.52
17 INT131645 Negative_regulation of Nf1 10 0.58 8.12 1.24 95.20
18 INT119102 Gene_expression of PDGFRA 13 0.75 11.99 0.81 94.72
19 INT156411 Gene_expression of Pdgfra 8 0.75 5.5 0.3 94.08
20 INT82117 Phosphorylation of NFASC 2 0.46 1.82 0.72 93.88
21 INT56925 Negative_regulation of TSC1 54 0.52 63.39 1.87 93.76
22 INT4993 Gene_expression of Lrrc23 13 0.66 11.04 1.99 93.64
23 INT68181 Binding of Nf1 6 0.48 8.14 1.88 92.36
24 INT37590 Regulation of COL7A1 15 0.54 9.4 3.12 92.04
25 INT78248 Negative_regulation of Cdkn2a 17 0.59 15.15 2.8 91.68
26 INT145302 Positive_regulation of Sox9 2 0.48 1.42 0.03 91.44
27 INT91891 Gene_expression of Kit 268 0.78 158.89 22.67 90.16
28 INT84510 Positive_regulation of Nf1 8 0.69 9.52 1.93 89.68
29 INT68180 Regulation of Nf1 2 0.27 2.02 0.22 89.44
30 INT175588 Regulation of MRAS 1 0.02 1.64 0 89.16
31 INT174574 Regulation of TAL1 2 0.01 1.62 0 89.16
32 INT5841 Gene_expression of Vim 181 0.72 138.54 16.33 89.04
33 INT6557 Gene_expression of Eno2 65 0.77 54.42 8.17 89.04
34 INT21681 Positive_regulation of CD34 54 0.66 33.95 4.14 88.72
35 INT25123 Negative_regulation of COL7A1 42 0.58 19.98 5.96 88.48
36 INT134661 Negative_regulation of Tp53 11 0.43 10.91 1.13 88.48
37 INT126734 Positive_regulation of MDM2 8 0.49 5.56 0 87.44
38 INT103196 Negative_regulation of Gene_expression of Nf1 1 0.57 1.21 0.16 87.08
39 INT249062 Positive_regulation of Positive_regulation of DES 1 0.49 1.29 0.03 86.72
40 INT179133 Localization of Nf1 2 0.80 2.18 0.68 86.28
41 INT51607 Positive_regulation of DES 33 0.67 32.24 3.29 86.20
42 INT84894 Gene_expression of Calb2 45 0.73 24.65 7.81 85.76
43 INT61434 Regulation of Nf1 3 0.26 1.39 2.4 84.32
44 INT21687 Positive_regulation of ras 143 0.58 97.34 27.31 84.28
45 INT67097 Gene_expression of MIB1 20 0.75 21.06 1.03 84.08
46 INT8347 Gene_expression of SST 181 0.78 104.59 65.45 81.72
47 INT169558 Positive_regulation of NF1 13 0.59 13.58 0 80.80
48 INT177938 Negative_regulation of NF1 9 0.43 10.3 0.2 80.80
49 INT175423 Positive_regulation of TSC1 25 0.36 21.81 0.45 77.52
50 INT6702 Binding of GLUL 3 0.21 2.04 0.28 75.12
51 INT90 Localization of Gast 400 0.81 137.67 113 73.00
52 INT228975 Gene_expression of SERPINA2 1 0.31 1.61 0 71.68
53 INT136531 Binding of Men1 8 0.47 9.62 0.65 69.28
54 INT83295 Positive_regulation of Cd68 21 0.39 14.55 2.46 65.52
55 INT68179 Gene_expression of Nf1 9 0.78 8.87 0.68 65.36
56 INT32905 Gene_expression of Mrc1 18 0.58 11.07 3.54 65.20
57 INT190023 Negative_regulation of Mrc1 15 0.25 12.36 0.16 65.20
58 INT190037 Negative_regulation of Gene_expression of Mrc1 1 0.21 1.86 0 65.20
59 INT57699 Positive_regulation of CD1A 11 0.50 8.49 2.93 64.80
60 INT29 Negative_regulation of Gast 74 0.59 24.85 24.96 63.44
61 INT79168 Binding of TNC 39 0.47 16.51 7.55 62.28
62 INT10214 Gene_expression of VIM 153 0.78 115.88 16.29 56.16
63 INT36200 Gene_expression of S100A1 9 0.77 9.56 0.75 50.24
64 INT74046 Localization of Calb2 12 0.80 2.05 2.24 50.00
65 INT29635 Localization of Eno2 9 0.76 6.05 1.35 50.00
66 INT97446 Localization of Mki67 9 0.46 3.74 0.46 50.00
67 INT166698 Localization of Vim 3 0.18 1.13 0.4 50.00
68 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 48.24
69 INT4554 Negative_regulation of Otor 5 0.35 2.04 3.5 40.20
70 INT190025 Positive_regulation of Gene_expression of Mrc1 2 0.22 0.82 0.03 38.96
71 INT190026 Positive_regulation of Gene_expression of Nf1 3 0.53 2.45 0.07 38.20
72 INT321203 Negative_regulation of Localization of SYT1 1 0.01 1 0 37.96
73 INT321202 Localization of SYT1 1 0.01 1 0 37.36
74 INT172209 Regulation of HAL 3 0.25 2.23 0.13 36.40
75 INT129341 Negative_regulation of Gene_expression of Nf1 2 0.43 1.67 0.2 35.64
76 INT190057 Positive_regulation of Negative_regulation of TSC1 2 0.01 1.08 0.03 35.64
77 INT190054 Negative_regulation of Positive_regulation of TSC1 1 0.01 0.83 0.03 35.64
78 INT103262 Localization of Nav1 53 0.81 19.23 34.44 26.84
79 INT88278 Binding of Kit 33 0.37 24.45 4.13 25.12
80 INT37722 Gene_expression of NCAM1 103 0.75 81.57 14.18 24.32
81 INT199308 Gene_expression of Krt8 37 0.75 23.17 1.06 24.32
82 INT190022 Positive_regulation of Mlh1 2 0.38 3.16 0.03 21.96
83 INT204019 Negative_regulation of C2 10 0.26 6.23 2.44 21.52
84 INT111477 Gene_expression of KRT7 90 0.74 86.76 4.07 8.88
85 INT296636 Regulation of Otor 1 0.05 0.71 0.24 5.60
86 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
87 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
88 INT24326 Gene_expression of Ngf 346 0.78 218.67 184.71 5.00
89 INT1793 Localization of CGA 379 0.81 67.38 114.69 5.00
90 INT1603 Negative_regulation of Rtcd1 131 0.51 29.99 66.66 5.00
91 INT14740 Gene_expression of TGFB1 272 0.78 168.48 60.18 5.00
92 INT546 Binding of ALB 311 0.48 85.98 60.14 5.00
93 INT96937 Gene_expression of Mmp9 191 0.75 150.3 56.01 5.00
94 INT27954 Positive_regulation of Gene_expression of Ngf 87 0.70 57.91 51.96 5.00
95 INT89 Positive_regulation of Gast 187 0.70 80.49 42.07 5.00
96 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 5.00
97 INT20210 Localization of Ngf 69 0.79 46.22 38.57 5.00
98 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38 5.00
99 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 5.00
100 INT6364 Gene_expression of Edn1 123 0.78 73.76 28.43 5.00
101 INT17739 Gene_expression of S100B 226 0.78 132.7 26.4 5.00
102 INT2614 Gene_expression of CGA 187 0.78 105.89 24.77 5.00
103 INT15390 Positive_regulation of Edn1 64 0.70 47.36 23.8 5.00
104 INT6868 Gene_expression of GFAP 136 0.78 84.65 22.7 5.00
105 INT14733 Positive_regulation of Gene_expression of TGFB1 71 0.69 49.89 22.2 5.00
106 INT11625 Localization of App 98 0.78 55.46 20.86 5.00
107 INT1792 Positive_regulation of CGA 123 0.70 64.73 20.79 5.00
108 INT170444 Binding of Gopc 172 0.39 45.05 20.71 5.00
109 INT16794 Binding of App 103 0.48 64.87 19.79 5.00
110 INT65502 Regulation of App 77 0.62 52.05 19.44 5.00
111 INT14737 Gene_expression of FN1 117 0.78 78.74 18.99 5.00
112 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71 5.00
113 INT81627 Gene_expression of Fas 120 0.78 115.51 15.36 5.00
114 INT109511 Gene_expression of Bax 133 0.78 113.22 14.36 5.00
115 INT77619 Gene_expression of Prkaca 43 0.75 8.55 14.13 5.00
116 INT27242 Gene_expression of PGR 153 0.75 98.77 12.79 5.00
117 INT24876 Gene_expression of CD34 172 0.78 91.02 12.39 5.00
118 INT8547 Gene_expression of MUC16 116 0.78 75.97 12.18 5.00
119 INT81640 Positive_regulation of Gene_expression of Bcl2 106 0.69 84.58 11.63 5.00
120 INT25963 Gene_expression of DES 122 0.75 98.81 11.25 5.00
121 INT94454 Gene_expression of CD68 73 0.72 63.94 10.43 5.00
122 INT27955 Negative_regulation of Gene_expression of Ngf 16 0.59 10.43 10.17 5.00
123 INT75955 Gene_expression of Drd3 19 0.77 4.39 10.07 5.00
124 INT6361 Localization of Edn1 30 0.81 19.09 9.7 5.00
125 INT6510 Gene_expression of AFP 130 0.78 119.2 9.19 5.00
126 INT33220 Negative_regulation of ras 110 0.58 70.21 9.19 5.00
127 INT64346 Positive_regulation of S100B 95 0.70 63.11 9.17 5.00
128 INT17101 Positive_regulation of Gene_expression of Edn1 24 0.69 24.9 8.86 5.00
129 INT6810 Gene_expression of ENO2 70 0.78 54.8 8.35 5.00
130 INT4991 Positive_regulation of Vim 74 0.69 69.84 8.33 5.00
131 INT53487 Gene_expression of TSC1 81 0.58 77.71 7.94 5.00
132 INT80220 Positive_regulation of Bcl2 71 0.58 57.73 7.86 5.00
133 INT111607 Gene_expression of CDH1 103 0.75 90.45 7.77 5.00
134 INT74520 Positive_regulation of CD68 30 0.61 31.68 7.59 5.00
135 INT76892 Gene_expression of FGFR1 45 0.69 23.6 7.56 5.00
136 INT6511 Positive_regulation of AFP 76 0.70 70.15 7.28 5.00
137 INT6476 Gene_expression of TNFRSF1B 21 0.67 18.22 5.25 5.00
138 INT87022 Gene_expression of Apc 68 0.67 46.98 5.22 5.00
139 INT15652 Positive_regulation of ENO2 37 0.68 33.39 5.02 5.00
140 INT140350 Binding of C2 17 0.36 3.97 4.69 5.00
141 INT47451 Positive_regulation of Positive_regulation of ras 18 0.35 10.07 4.6 5.00
142 INT22080 Regulation of ras 40 0.53 36.24 4.44 5.00
143 INT89963 Regulation of Fas 15 0.59 8.25 4.32 5.00
144 INT81628 Positive_regulation of Gene_expression of Fas 32 0.67 38.13 4.23 5.00
145 INT76714 Binding of Drd3 9 0.37 2.33 4.09 5.00
146 INT123752 Regulation of Bax 19 0.60 16.45 4 5.00
147 INT112692 Localization of Bax 31 0.80 20.97 3.98 5.00
148 INT6507 Binding of C5 23 0.48 15.35 3.91 5.00
149 INT75485 Gene_expression of Tgfbr2 10 0.57 10.98 3.76 5.00
150 INT62784 Gene_expression of NT5E 46 0.65 15.95 3.72 5.00
151 INT95652 Gene_expression of Krt20 54 0.61 53.69 3.31 5.00
152 INT141180 Gene_expression of Apaf1 6 0.74 5.77 2.98 5.00
153 INT99419 Regulation of Drd3 7 0.48 1.89 2.81 5.00
154 INT134795 Positive_regulation of Scrib 30 0.22 36.91 2.81 5.00
155 INT89327 Positive_regulation of Gene_expression of Drd3 4 0.54 0.32 2.64 5.00
156 INT61907 Negative_regulation of Ebp 9 0.37 4.77 2.49 5.00
157 INT59784 Binding of DES 22 0.47 19.48 2.27 5.00
158 INT190028 Positive_regulation of Mrc1 10 0.22 2.94 2.26 5.00
159 INT5844 Positive_regulation of Gene_expression of Vim 14 0.25 9.64 2.18 5.00
160 INT85085 Positive_regulation of KIT 36 0.53 30.08 2.17 5.00
161 INT81641 Gene_expression of Ctnnb1 23 0.72 14.93 1.97 5.00
162 INT111143 Regulation of Gene_expression of KRT20 22 0.26 5.65 1.93 5.00
163 INT135540 Negative_regulation of Bax 16 0.48 11.8 1.89 5.00
164 INT97073 Positive_regulation of Ebp 6 0.42 2.68 1.8 5.00
165 INT15692 Regulation of HTC2 4 0.27 4.75 1.61 5.00
166 INT109512 Negative_regulation of Gene_expression of Bax 12 0.42 8.04 1.44 5.00
167 INT85829 Gene_expression of CA9 14 0.68 12.59 1.4 5.00
168 INT172452 Gene_expression of Myc 121 0.78 69.56 1.36 5.00
169 INT214073 Binding of TSC1 9 0.37 22 1.34 5.00
170 INT160606 Localization of AFP 6 0.74 3.39 1.29 5.00
171 INT190014 Regulation of Pten 8 0.62 6.03 1.2 5.00
172 INT93168 Gene_expression of Ttf1 24 0.63 17.18 1.14 5.00
173 INT89967 Negative_regulation of Gene_expression of Fas 19 0.58 19.28 1.1 5.00
174 INT177615 Gene_expression of PAX7 20 0.65 13.5 1.03 5.00
175 INT190031 Binding of Scrib 19 0.36 21.9 1.01 5.00
176 INT287954 Gene_expression of DVL1 8 0.24 2.48 0.83 5.00
177 INT96188 Binding of Cd34 11 0.31 10.4 0.82 5.00
178 INT74019 Regulation of TSC1 27 0.35 23.61 0.79 5.00
179 INT259042 Gene_expression of D18Tlj1e 1 0.06 1.85 0.74 5.00
180 INT129783 Positive_regulation of Gene_expression of KIT 16 0.50 18.12 0.58 5.00
181 INT259041 Binding of D18Tlj1e 1 0.03 1.98 0.57 5.00
182 INT111609 Gene_expression of CTNNA1 3 0.46 3.2 0.57 5.00
183 INT190041 Positive_regulation of Bcl2a1b 2 0.04 1 0.55 5.00
184 INT35896 Regulation of Mrc1 4 0.44 1.33 0.49 5.00
185 INT119251 Positive_regulation of Gene_expression of CD34 12 0.49 5.2 0.44 5.00
186 INT196916 Negative_regulation of Rb1 13 0.42 14.29 0.4 5.00
187 INT190017 Localization of Scrib 6 0.10 7 0.38 5.00
188 INT30049 Gene_expression of Bcl10 4 0.51 2.36 0.35 5.00
189 INT228977 Binding of SERPINA2 1 0.25 5.42 0.35 5.00
190 INT191601 Negative_regulation of Fdft1 2 0.04 2.13 0.33 5.00
191 INT190042 Gene_expression of Bcl2a1b 7 0.05 5.74 0.33 5.00
192 INT185886 Gene_expression of JUP 20 0.75 15.41 0.32 5.00
193 INT190032 Negative_regulation of Cdx2 2 0.38 0.74 0.3 5.00
194 INT97779 Negative_regulation of TSC2 3 0.41 3.45 0.26 5.00
195 INT181808 Gene_expression of Pax7 18 0.54 6.22 0.26 5.00
196 INT190010 Transcription of Cdx2 1 0.53 0.69 0.26 5.00
197 INT11156 Gene_expression of TGFA 4 0.61 3.03 0.26 5.00
198 INT234614 Phosphorylation of KIT 6 0.78 4.85 0.23 5.00
199 INT183062 Gene_expression of SHH 12 0.65 5.28 0.21 5.00
200 INT228976 Binding of MCAT 3 0.06 3.45 0.17 5.00
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