D:Neurofibromatosis 2

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Disease Term
Synonyms 2 Neurofibromatoses Type, 2 NEUROFIBROMATOSIS TYPE, 2s Neurofibromatosis Type, ACOUSTIC NEUROFIBROMATOSES BILATERAL, Acoustic Neurofibromatosis Bilateral, ACOUSTIC NEUROMA FAMILIAL, Acoustic Neuromas Familial, Bilateral Acoustic Neurofibromatoses, Bilateral Acoustic Neurofibromatosis, CENTRAL NF2 NEUROFIBROMATOSES, CENTRAL NF2 NEUROFIBROMATOSIS
Documents 32
Hot Single Events 28
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Neurofibromatosis 2. They are ordered first by their relevance to Neurofibromatosis 2 and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT225230 Ad Positive_regulation of Nf2 1 0.04 1.37 0.04 98.04
2 INT321597 Binding of MUC1 and MIB1 1 0.19 0.98 0.08 83.16
3 INT217142 MIR98 Regulation of Gene_expression of HMGA2 1 0.40 2.22 0 56.16
4 INT217151 Gene_expression of MIR98 Negative_regulation of HMGA2 1 0.24 1.08 0 51.44
5 INT225228 Binding of Cdk4 and Cdkn2a 1 0.21 1.24 0 48.64
6 INT225229 Binding of Cdk6 and Cdkn2a 1 0.19 1.25 0 48.64
7 INT242015 Binding of Mdm2 and Trp53 3 0.16 5.74 0 40.04
8 INT217148 MIR21 Regulation of BCL2 1 0.32 0.98 0.03 5.00
9 INT217139 Binding of MIR103A2 and MIR107 1 0.06 0.83 0 5.00
10 INT217145 Gene_expression of MIR26B Negative_regulation of Gene_expression of MCL1 1 0.10 1 0 5.00
11 INT217143 MIR29A Regulation of Gene_expression of MCL1 1 0.24 1 0 5.00
12 INT217136 Negative_regulation of MIR221 Negative_regulation of Gene_expression of KIT 1 0.18 0.74 0 5.00
13 INT217144 MIR21 Negative_regulation of TPM1 1 0.06 1.03 0 5.00
14 INT217150 MIR16-2 Regulation of BCL2 2 0.09 1.89 0 5.00
15 INT217149 MIR20A Regulation of Gene_expression of E2F1 1 0.19 0.86 0 5.00
16 INT217137 MIR15B Regulation of BCL2 2 0.15 1.88 0 5.00
17 INT217141 Binding of BCL2 and MIR15B 1 0.21 1.26 0 5.00
18 INT217138 Negative_regulation of MIR222 Negative_regulation of Gene_expression of KIT 1 0.16 0.74 0 5.00
19 INT217146 Binding of BCL2 and MIR16-2 1 0.12 1.25 0 5.00
20 INT217147 MIR17 Regulation of Gene_expression of E2F1 1 0.20 0.85 0 5.00
21 INT217140 MIR223 Regulation of CEBPA 1 0.17 0.59 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Neurofibromatosis 2. They are ordered first by their pain relevance and then by number of times they were reported in Neurofibromatosis 2. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT225221 Negative_regulation of Nf2 1 0.57 18.06 0.83 100.00
2 INT164841 Gene_expression of Nf2 3 0.67 1.23 0 100.00
3 INT125226 Binding of Nf2 7 0.48 5.94 2.02 100.00
4 INT133293 Positive_regulation of Nf2 3 0.49 1.67 0.27 100.00
5 INT225224 Positive_regulation of Nf2 1 0.59 3.4 0.12 100.00
6 INT129118 Negative_regulation of NF2 2 0.56 1.89 0.15 100.00
7 INT202848 Gene_expression of Nf2 5 0.59 4.93 0.63 100.00
8 INT225222 Negative_regulation of Negative_regulation of Nf2 1 0.41 1.55 0.11 100.00
9 INT225226 Positive_regulation of Negative_regulation of Ccnd1 1 0.14 1.18 0.03 99.76
10 INT128987 Negative_regulation of Ccnd1 24 0.52 15.78 1.15 99.56
11 INT114875 Negative_regulation of Cdk4 4 0.35 4.01 0.86 99.56
12 INT217203 Positive_regulation of Phosphorylation of PROC 1 0.01 1.96 0 98.96
13 INT212047 Phosphorylation of PROC 2 0.13 1.41 0 98.96
14 INT78472 Gene_expression of CDKN2A 223 0.78 173.76 13.61 98.80
15 INT92141 Negative_regulation of CDKN2A 53 0.57 44.23 2.48 98.80
16 INT169911 Phosphorylation of Rb1 35 0.73 18.58 0.79 98.26
17 INT217219 Binding of MIRLET7A3 1 0.15 1.01 0 98.16
18 INT174156 Localization of Trp53 16 0.72 13.52 1.18 96.64
19 INT129771 Regulation of SMARCB1 5 0.58 8.92 0.58 94.96
20 INT225227 Gene_expression of NF2 4 0.65 4.49 0.03 94.88
21 INT217209 Regulation of MIRLET7A3 1 0.25 1.03 0 94.24
22 INT129115 Negative_regulation of Cdkn2a 16 0.50 17.03 0.76 93.52
23 INT225216 Negative_regulation of Negative_regulation of Cdkn2a 1 0.42 3.16 0.15 90.72
24 INT225215 Negative_regulation of Positive_regulation of Ccnd1 2 0.13 1.33 0 89.52
25 INT225220 Positive_regulation of Positive_regulation of Ccnd1 1 0.14 1.2 0 87.92
26 INT109007 Positive_regulation of Ccnd1 23 0.53 9.5 0.86 87.40
27 INT217225 Negative_regulation of Negative_regulation of HMGA2 1 0.55 2.4 0 82.00
28 INT217195 Negative_regulation of HMGA2 1 0.55 3.54 0 81.44
29 INT217124 Positive_regulation of Mirlet7a-1 3 0.08 1.78 0.16 78.64
30 INT217193 Negative_regulation of Negative_regulation of AXL 1 0.01 1.12 0 78.20
31 INT217179 Negative_regulation of AXL 2 0.01 1.9 0 77.28
32 INT71602 Negative_regulation of Trp53 84 0.59 67.77 3.68 73.68
33 INT64233 Regulation of Trp53 35 0.62 27.11 1.53 68.36
34 INT242003 Negative_regulation of Tgs1 1 0.01 1.09 0 67.92
35 INT225225 Negative_regulation of Gene_expression of Cyp2b10 2 0.29 2.43 0.27 65.16
36 INT183399 Gene_expression of Cyp2b10 17 0.39 18.39 0.71 64.84
37 INT43637 Positive_regulation of AXL 11 0.58 11.71 1.59 63.36
38 INT196323 Localization of Cdkn2a 8 0.73 9.1 0.32 61.56
39 INT225223 Localization of Cdkn2b 2 0.62 1.29 0.37 61.56
40 INT21611 Negative_regulation of RASGRP1 20 0.35 11.76 2.15 56.24
41 INT217125 Negative_regulation of Gene_expression of Dld 1 0.41 0.72 0 56.24
42 INT88987 Gene_expression of HMGA2 8 0.77 10.46 0.64 56.16
43 INT217122 Gene_expression of Dld 1 0.65 0.71 0 53.04
44 INT60198 Binding of JUN 54 0.48 11.56 10.27 52.84
45 INT7904 Positive_regulation of Gene_expression of Fosl1 5 0.61 1.39 2.96 51.52
46 INT217181 Negative_regulation of Gene_expression of MIR98 1 0.26 1.08 0 51.44
47 INT217216 Gene_expression of MIR98 1 0.47 1.07 0 51.44
48 INT217200 Positive_regulation of Gene_expression of MIR98 1 0.28 1.07 0 51.44
49 INT5199 Gene_expression of Fosl1 44 0.78 8.66 24.8 51.12
50 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 48.80
51 INT99690 Negative_regulation of Positive_regulation of VEGFA 30 0.58 14.56 4.79 48.80
52 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 48.40
53 INT94085 Binding of NFASC 10 0.17 7.1 2.5 48.40
54 INT242011 Localization of Cdkn2a 4 0.73 2.49 0.54 48.08
55 INT4188 Binding of NF2 7 0.46 3.52 1.79 43.52
56 INT89392 Negative_regulation of Positive_regulation of AKT1 23 0.50 15.69 3.02 41.68
57 INT172957 Negative_regulation of Mdm2 4 0.14 4.28 0.3 41.08
58 INT94164 Phosphorylation of RB1 83 0.80 48.84 3.21 40.96
59 INT86187 Positive_regulation of AKT1 199 0.69 122.13 19.44 40.36
60 INT8068 Gene_expression of RASGRP1 29 0.54 15.1 1.37 39.20
61 INT106525 Phosphorylation of Akt1 436 0.82 183.81 47.82 38.80
62 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27 27.12
63 INT8063 Regulation of RASGRP1 15 0.36 9.15 1.3 19.28
64 INT204170 Binding of Mri1 5 0.22 4.45 1.11 8.16
65 INT73262 Negative_regulation of BCL2 67 0.57 61.01 5.07 7.52
66 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
67 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51 5.00
68 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 5.00
69 INT62374 Gene_expression of NGF 158 0.78 77.87 76.45 5.00
70 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 5.00
71 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34 5.00
72 INT73048 Gene_expression of MMP9 268 0.77 159.75 57.81 5.00
73 INT26500 Gene_expression of MMP2 201 0.78 110.57 46.9 5.00
74 INT71786 Phosphorylation of MAPK1 256 0.82 110.09 46.17 5.00
75 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 5.00
76 INT25383 Gene_expression of Csf2 222 0.76 152.93 43.32 5.00
77 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 5.00
78 INT114881 Gene_expression of Akt1 227 0.78 102.49 31.81 5.00
79 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 5.00
80 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73 5.00
81 INT23435 Positive_regulation of NGF 54 0.70 32.41 30.11 5.00
82 INT165054 Gene_expression of MIR146A 45 0.58 82.87 28.82 5.00
83 INT55737 Positive_regulation of MMP2 101 0.68 59.11 27.71 5.00
84 INT73047 Positive_regulation of MMP9 133 0.68 73.22 26.42 5.00
85 INT62710 Gene_expression of HGF 160 0.78 88.27 26.14 5.00
86 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 5.00
87 INT12124 Gene_expression of MAPK1 141 0.75 82.4 25.58 5.00
88 INT22708 Gene_expression of MUC1 297 0.78 232.71 24.19 5.00
89 INT91891 Gene_expression of Kit 268 0.78 158.89 22.67 5.00
90 INT48312 Gene_expression of NTRK1 72 0.78 38.21 22.24 5.00
91 INT73593 Gene_expression of BAX 173 0.76 147.81 20.94 5.00
92 INT28215 Gene_expression of CDKN1A 196 0.76 113.9 18.3 5.00
93 INT10834 Binding of IL8 65 0.48 41.66 16.53 5.00
94 INT99898 Gene_expression of Mmp14 37 0.56 28.54 16.39 5.00
95 INT75531 Regulation of MAPK1 70 0.61 34.39 15.42 5.00
96 INT116465 Gene_expression of Birc5 241 0.78 192.31 15.32 5.00
97 INT20420 Gene_expression of MYC 99 0.75 49.32 14.36 5.00
98 INT37722 Gene_expression of NCAM1 103 0.75 81.57 14.18 5.00
99 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32 5.00
100 INT27242 Gene_expression of PGR 153 0.75 98.77 12.79 5.00
101 INT28420 Gene_expression of Ptgds 59 0.78 31.72 12.67 5.00
102 INT24876 Gene_expression of CD34 172 0.78 91.02 12.39 5.00
103 INT112003 Localization of ROS1 94 0.73 66.32 12.16 5.00
104 INT25963 Gene_expression of DES 122 0.75 98.81 11.25 5.00
105 INT80037 Gene_expression of BAK1 58 0.75 39.49 9.08 5.00
106 INT9548 Gene_expression of CHKB 99 0.65 50.86 9.03 5.00
107 INT69264 Gene_expression of KIT 207 0.78 179.41 8.95 5.00
108 INT104396 Positive_regulation of Positive_regulation of Akt1 44 0.55 14.78 8.69 5.00
109 INT144430 Gene_expression of Erbb2 137 0.77 103.87 8.66 5.00
110 INT66041 Positive_regulation of NTRK1 24 0.70 16.12 8.42 5.00
111 INT65959 Positive_regulation of Gene_expression of BCL2 75 0.70 77.3 8.27 5.00
112 INT92680 Gene_expression of Fgf2 59 0.77 28.11 8.12 5.00
113 INT53487 Gene_expression of TSC1 81 0.58 77.71 7.94 5.00
114 INT217186 Gene_expression of MIR155 26 0.48 29.45 7.92 5.00
115 INT111607 Gene_expression of CDH1 103 0.75 90.45 7.77 5.00
116 INT95133 Gene_expression of FASLG 38 0.75 44.09 7.51 5.00
117 INT103154 Gene_expression of FLT1 138 0.76 58.5 7.41 5.00
118 INT84685 Regulation of BCL2 67 0.60 72.96 6.65 5.00
119 INT173967 Gene_expression of Mri1 26 0.43 16.67 6.45 5.00
120 INT114882 Positive_regulation of Gene_expression of Akt1 45 0.69 21.29 6.06 5.00
121 INT87470 Gene_expression of SDC1 27 0.78 24.86 5.81 5.00
122 INT123726 Positive_regulation of Notch1 23 0.70 7.2 5.65 5.00
123 INT164587 Gene_expression of MCL1 94 0.75 124.05 5.39 5.00
124 INT87420 Gene_expression of BCL2L1 56 0.75 48.84 5.32 5.00
125 INT80038 Positive_regulation of Gene_expression of MYC 24 0.67 13.93 5.17 5.00
126 INT116464 Negative_regulation of Birc5 53 0.59 45.4 4.91 5.00
127 INT103155 Gene_expression of KDR 78 0.66 50.53 4.38 5.00
128 INT101858 Negative_regulation of BAX 25 0.57 23.77 4.16 5.00
129 INT4988 Gene_expression of KRT1 64 0.77 43.4 4.12 5.00
130 INT111477 Gene_expression of KRT7 90 0.74 86.76 4.07 5.00
131 INT68269 Gene_expression of CD99 49 0.77 47.38 3.86 5.00
132 INT84809 Positive_regulation of Gene_expression of MUC1 39 0.70 36.42 3.75 5.00
133 INT228465 Positive_regulation of Timp2 4 0.64 6.29 3.54 5.00
134 INT179338 Gene_expression of Timp2 7 0.55 5.75 3.13 5.00
135 INT91173 Gene_expression of Pdgfrb 33 0.65 32.55 3.09 5.00
136 INT91890 Positive_regulation of Kit 36 0.50 25.44 3.06 5.00
137 INT188047 Positive_regulation of Wnt2 51 0.58 31.41 2.94 5.00
138 INT116463 Negative_regulation of Gene_expression of Birc5 40 0.59 33.99 2.74 5.00
139 INT16463 Gene_expression of FTH1 15 0.65 6.28 2.66 5.00
140 INT182312 Positive_regulation of Gene_expression of Birc5 26 0.69 25.3 2.32 5.00
141 INT163283 Gene_expression of E2F1 21 0.71 3.77 2.26 5.00
142 INT109327 Negative_regulation of KIT 42 0.57 43.2 2.15 5.00
143 INT29035 Negative_regulation of Wnt1 3 0.41 1.47 2 5.00
144 INT164583 Negative_regulation of Gene_expression of MCL1 19 0.56 22.45 1.94 5.00
145 INT144020 Positive_regulation of Pdgfrb 30 0.69 24.8 1.92 5.00
146 INT107905 Gene_expression of BCL2L11 9 0.75 7.58 1.92 5.00
147 INT105162 Gene_expression of Ad 47 0.12 46.53 1.83 5.00
148 INT62712 Negative_regulation of HGF 19 0.58 7.21 1.67 5.00
149 INT129492 Gene_expression of Hpse 11 0.75 6.56 1.59 5.00
150 INT125871 Gene_expression of XIAP 5 0.65 11.46 1.46 5.00
151 INT166021 Positive_regulation of MCL1 36 0.67 62.97 1.44 5.00
152 INT172953 Binding of Trp53 33 0.37 20.76 1.41 5.00
153 INT49128 Gene_expression of IGF1R 35 0.63 23.48 1.39 5.00
154 INT144019 Negative_regulation of Pdgfrb 21 0.58 14.93 1.26 5.00
155 INT171512 Gene_expression of RARS 4 0.45 2.56 1.17 5.00
156 INT157765 Negative_regulation of CDH1 32 0.53 35.72 1.15 5.00
157 INT147336 Gene_expression of HLA-G 12 0.75 7.27 1.08 5.00
158 INT217167 Negative_regulation of Gene_expression of MIR155 4 0.23 3.43 0.91 5.00
159 INT173003 Negative_regulation of Gene_expression of MUC1 15 0.57 10.27 0.79 5.00
160 INT74019 Regulation of TSC1 27 0.35 23.61 0.79 5.00
161 INT138955 Transcription of EGFR 18 0.71 11.39 0.78 5.00
162 INT217157 Gene_expression of MIR34A 9 0.58 9.36 0.77 5.00
163 INT101209 Gene_expression of Wt1 19 0.72 25.77 0.7 5.00
164 INT140037 Positive_regulation of Positive_regulation of Notch1 2 0.22 1.34 0.69 5.00
165 INT217168 Gene_expression of MIR21 30 0.55 30.86 0.62 5.00
166 INT185240 Binding of Fgf2 14 0.37 7.39 0.59 5.00
167 INT129493 Protein_catabolism of Hpse 2 0.55 2.81 0.57 5.00
168 INT94165 Negative_regulation of RB1 30 0.52 27.29 0.51 5.00
169 INT242004 Binding of Tcf7 4 0.36 2.66 0.49 5.00
170 INT217160 Gene_expression of MIR223 5 0.44 2.41 0.48 5.00
171 INT189446 Gene_expression of MSLN 24 0.42 13.37 0.47 5.00
172 INT186998 Negative_regulation of Gene_expression of KIT 20 0.43 16.77 0.46 5.00
173 INT175423 Positive_regulation of TSC1 25 0.36 21.81 0.45 5.00
174 INT121860 Negative_regulation of BID 2 0.29 1.92 0.38 5.00
175 INT135638 Binding of Dst 4 0.36 2.76 0.38 5.00
176 INT217156 Positive_regulation of Gene_expression of MIR21 9 0.49 16.04 0.38 5.00
177 INT277164 Gene_expression of Cdh3 2 0.01 2.88 0.35 5.00
178 INT217162 Negative_regulation of MIR21 7 0.30 7.01 0.34 5.00
179 INT143703 Gene_expression of MIR196A2 3 0.75 2.52 0.32 5.00
180 INT189445 Positive_regulation of MSLN 20 0.37 3.5 0.3 5.00
181 INT217210 Negative_regulation of Gene_expression of MIR143 2 0.27 2.29 0.3 5.00
182 INT217166 Gene_expression of MIR17HG 7 0.58 7.09 0.29 5.00
183 INT217208 Positive_regulation of Gene_expression of MIR155 3 0.31 2.7 0.29 5.00
184 INT217164 Gene_expression of MIR143 2 0.37 2.27 0.29 5.00
185 INT217152 Gene_expression of MIR145 4 0.43 5.15 0.29 5.00
186 INT144021 Binding of Pdgfrb 9 0.37 5.53 0.28 5.00
187 INT225219 Positive_regulation of Gene_expression of Nf2 1 0.43 1.27 0.27 5.00
188 INT217182 Gene_expression of MIR221 4 0.58 9.33 0.27 5.00
189 INT164734 Positive_regulation of Gene_expression of MIR29A 3 0.67 2.1 0.24 5.00
190 INT124944 Regulation of KIT 15 0.60 11.84 0.24 5.00
191 INT164735 Gene_expression of MIR29A 4 0.75 2.98 0.24 5.00
192 INT192957 Transcription of KIT 5 0.69 2.19 0.23 5.00
193 INT217214 Negative_regulation of MIR17 2 0.24 1.37 0.2 5.00
194 INT198036 Negative_regulation of BAK1 5 0.27 5.98 0.17 5.00
195 INT213534 Positive_regulation of Ctnnd2 7 0.67 3.79 0.15 5.00
196 INT125873 Positive_regulation of Gene_expression of XIAP 2 0.49 2.51 0.13 5.00
197 INT217189 Gene_expression of MIR222 5 0.46 4.58 0.12 5.00
198 INT277185 Gene_expression of BIRC7 1 0.07 4.7 0.12 5.00
199 INT169172 Positive_regulation of XIAP 3 0.49 2.54 0.12 5.00
200 INT213951 Gene_expression of MIR301A 2 0.36 2.34 0.11 5.00
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