D:Neuroma

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Disease Term
Synonyms Neuromas
Documents 864
Hot Single Events 189
Hot Interactions 3

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Neuroma. They are ordered first by their relevance to Neuroma and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT190128 Positive_regulation of PTGER1 Negative_regulation of Gene_expression of CPOX 1 0.04 1.21 1.38 95.84
2 INT69340 Binding of Igh-6 and Ngf 2 0.06 1.04 1.06 93.40
3 INT136603 Calca Positive_regulation of Localization of Il6 1 0.67 0.78 1.32 90.48
4 INT351374 Mir470 Negative_regulation of Ntrk3 1 0.00 1.55 0.7 75.00
5 INT351375 Mir470 Negative_regulation of Ntrk2 1 0.01 1.54 0.7 75.00
6 INT351376 Mir470 Negative_regulation of Ntrk1 1 0.01 1.54 0.7 75.00
7 INT77646 Binding of Ngf and Ntrk1 23 0.40 7.85 9.26 53.08
8 INT88279 Ngf Positive_regulation of Ntrk1 5 0.76 3.06 5.23 50.00
9 INT351380 Ngf Regulation of TPM1 1 0.44 2.17 2.11 50.00
10 INT351379 Ngf Positive_regulation of Binding of Ngf and Ntrk1 1 0.38 0.63 1.21 50.00
11 INT351373 Ngf Positive_regulation of Gene_expression of Ntrk1 1 0.35 0.41 1.18 50.00
12 INT351378 Gene_expression of Ngf Positive_regulation of Ntrk1 1 0.35 0.41 1.18 50.00
13 INT351377 Gene_expression of Ngf Positive_regulation of Gene_expression of Ntrk1 1 0.35 0.41 1.18 50.00
14 INT120834 Binding of CNTN1 and SCN3A 1 0.01 0.41 0.49 49.68
15 INT283049 Car2 Positive_regulation of Trpa1 1 0.20 1.33 0.67 34.08
16 INT209250 TRPV1 Positive_regulation of Localization of DRGX 1 0.06 0.82 0.68 18.96
17 INT283050 Binding of Gad2 and Trpm8 1 0.23 2.02 1.93 5.20
18 INT84921 Binding of NGF and NTRK1 13 0.50 6.39 6.1 5.00
19 INT127128 Binding of CNR1 and CNR2 8 0.39 3.98 3.97 5.00
20 INT220062 Binding of NGF and TNFRSF1B 1 0.10 2.21 2.81 5.00
21 INT220061 Binding of TRPV1 and TRPA1 1 0.15 1.7 2.69 5.00
22 INT103548 Binding of TRPV1 and TRPV3 3 0.37 1.82 2.28 5.00
23 INT185097 NGF Regulation of Gene_expression of NAV1 1 0.61 0.81 1.85 5.00
24 INT220058 NGF Positive_regulation of Gene_expression of BDNF 1 0.12 1.31 1.48 5.00
25 INT220059 NGF Positive_regulation of Positive_regulation of BDNF 1 0.11 1.31 1.48 5.00
26 INT220060 Negative_regulation of Binding of NGF and NTRK1 1 0.08 1.11 1.39 5.00
27 INT190130 Binding of CPOX and MRXS5 1 0.00 1.4 1.23 5.00
28 INT220056 Binding of NTF3 and NTRK1 1 0.07 1.12 0.78 5.00
29 INT220063 Binding of NTF3 and NTRK2 1 0.09 1.13 0.78 5.00
30 INT220057 Binding of NTS and TNFRSF1B 1 0.08 1.23 0.76 5.00
31 INT310712 Gabrg1 Positive_regulation of Gene_expression of PMP22 1 0.35 0.56 0.61 5.00
32 INT310701 RPLP0 Regulation of Positive_regulation of PGR 1 0.01 0.49 0.53 5.00
33 INT310711 Binding of RPLP0 and Gabrg1 1 0.04 0.37 0.45 5.00
34 INT263072 Kncn Regulation of Transcription of Trpm8 1 0.08 0.99 0.36 5.00
35 INT310700 PGR Regulation of Gene_expression of RPLP0 1 0.01 0.37 0.25 5.00
36 INT199159 Binding of RET and Pheo 1 0.04 1.42 0.03 5.00
37 INT315669 Binding of Nes and Nos1 1 0.20 0 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Neuroma. They are ordered first by their pain relevance and then by number of times they were reported in Neuroma. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT102429 Negative_regulation of Gene_expression of Nav1 19 0.59 20.09 28.09 100.00
2 INT115909 Positive_regulation of Gene_expression of Nav1 25 0.70 16.58 27.63 100.00
3 INT2541 Binding of Calca 200 0.48 67.14 134.62 100.00
4 INT102262 Localization of NF2 1 0.14 0.6 0.79 100.00
5 INT148639 Gene_expression of Uchl1 30 0.59 16.76 11.54 100.00
6 INT351372 Regulation of Localization of Ntrk1 1 0.34 0.92 0 100.00
7 INT243712 Positive_regulation of Gene_expression of Uchl1 4 0.21 2.68 0.61 100.00
8 INT243713 Positive_regulation of Gene_expression of Gbp1 2 0.12 2.58 0 100.00
9 INT88237 Gene_expression of Gbp1 9 0.65 5.46 0.61 100.00
10 INT58475 Localization of Rac1 12 0.75 5.94 3.2 100.00
11 INT6601 Gene_expression of PPAP2A 21 0.27 3.13 5.52 99.96
12 INT62373 Negative_regulation of NGF 34 0.59 25.87 22.38 99.92
13 INT70418 Negative_regulation of CNTF 1 0.58 0.62 0.63 99.92
14 INT127500 Gene_expression of TRPA1 79 0.78 24.58 23.3 99.84
15 INT70980 Negative_regulation of Scnn1g 8 0.23 3.11 5.31 99.84
16 INT18357 Gene_expression of TRPV1 825 0.78 307.11 382.81 99.84
17 INT203508 Gene_expression of Eno2 12 0.65 4.98 1.55 99.84
18 INT2543 Positive_regulation of Calca 787 0.70 331.13 592.08 99.84
19 INT98687 Gene_expression of Calr 38 0.61 7.03 1.59 99.84
20 INT243715 Gene_expression of Cct2 2 0.27 1.2 0.1 99.84
21 INT78749 Gene_expression of SCN10A 25 0.75 9.23 16.5 99.76
22 INT85214 Gene_expression of SCN11A 24 0.78 4.05 12.5 99.76
23 INT72709 Gene_expression of Scnn1g 5 0.40 1.53 1.22 99.72
24 INT46460 Gene_expression of NAV1 288 0.78 135.51 305.75 99.70
25 INT26585 Gene_expression of Vim 117 0.77 39.97 6 99.68
26 INT193676 Positive_regulation of Gene_expression of Prdx2 2 0.06 1.31 0.09 99.68
27 INT193672 Gene_expression of Prdx2 3 0.50 2.75 0.64 99.68
28 INT169703 Positive_regulation of Gene_expression of Vim 7 0.38 2.56 1.09 99.68
29 INT81194 Binding of CPOX 40 0.29 23.7 18.95 99.66
30 INT23128 Binding of PTGER1 4 0.27 1.82 2.45 99.66
31 INT2542 Localization of Calca 2008 0.81 518.3 1408.65 99.64
32 INT10536 Gene_expression of Trib3 67 0.66 27.08 21.58 99.62
33 INT102260 Localization of ANK1 2 0.71 0.74 1.31 99.60
34 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 99.52
35 INT120836 Positive_regulation of CNTN1 1 0.48 1.42 1.4 99.52
36 INT3300 Positive_regulation of Gene_expression of Calca 179 0.70 77.76 144.2 99.52
37 INT11377 Positive_regulation of Ngf 331 0.70 206.5 238 99.48
38 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02 99.46
39 INT54924 Gene_expression of RLS 67 0.62 83.2 14.25 99.46
40 INT74520 Positive_regulation of CD68 30 0.61 31.68 7.59 99.44
41 INT204990 Positive_regulation of Gene_expression of Park7 2 0.24 1.79 0.05 99.44
42 INT77368 Regulation of Regulation of Il6 3 0.35 1.86 1.45 99.42
43 INT50972 Negative_regulation of Ntrk1 39 0.51 32.22 17.29 99.24
44 INT1727 Gene_expression of Cndp2 22 0.74 4.28 3.34 99.24
45 INT17546 Negative_regulation of Ngf 135 0.59 60.28 77.19 99.20
46 INT1395 Negative_regulation of Penk 537 0.59 87.33 389.81 99.20
47 INT1712 Positive_regulation of Negative_regulation of Penk 10 0.67 1.48 7.06 99.20
48 INT11313 Positive_regulation of Il6 526 0.70 331.27 201.59 99.10
49 INT102102 Binding of GFRA1 2 0.05 2.75 0.21 99.10
50 INT48313 Binding of NTRK1 19 0.47 14.44 6.12 99.10
51 INT102100 Binding of PSIP1 1 0.24 0.34 0.05 99.10
52 INT71150 Binding of NGF 22 0.46 13.67 14.81 99.10
53 INT2649 Regulation of Calca 433 0.62 146.05 330.95 99.08
54 INT204986 Gene_expression of Park7 5 0.38 5.48 0.1 99.04
55 INT10706 Regulation of Il6 150 0.62 93.23 62.34 99.04
56 INT50672 Positive_regulation of CPOX 205 0.44 125.93 60.06 99.00
57 INT66041 Positive_regulation of NTRK1 24 0.70 16.12 8.42 99.00
58 INT27133 Gene_expression of Nfkbiz 5 0.60 0.74 1.5 99.00
59 INT97237 Transcription of TRPV1 33 0.72 10.56 12.4 99.00
60 INT21952 Gene_expression of GDNF 42 0.78 20.32 9.62 98.92
61 INT62374 Gene_expression of NGF 158 0.78 77.87 76.45 98.92
62 INT4781 Gene_expression of TH 68 0.73 26.92 24.01 98.76
63 INT23420 Positive_regulation of Spn 8 0.49 4.81 0.69 98.72
64 INT12124 Gene_expression of MAPK1 141 0.75 82.4 25.58 98.64
65 INT71785 Gene_expression of MAPK3 22 0.75 11.35 8.21 98.64
66 INT38859 Gene_expression of SGSM3 14 0.75 12.98 4.09 98.64
67 INT86646 Positive_regulation of SCN10A 71 0.69 50.61 13.24 98.64
68 INT6623 Gene_expression of NA 231 0.78 45.78 59.36 98.64
69 INT23886 Positive_regulation of Gene_expression of NA 15 0.40 3.69 3.59 98.64
70 INT129303 Positive_regulation of NAV1 54 0.70 36.92 57.45 98.52
71 INT178338 Gene_expression of Tbx15 50 0.65 38.65 12.19 98.36
72 INT104663 Positive_regulation of SCN9A 3 0.60 0.42 2.54 98.32
73 INT97367 Gene_expression of Nav1 243 0.78 132.97 286.66 98.28
74 INT47683 Negative_regulation of Bdnf 92 0.59 47.53 43.55 98.20
75 INT207735 Negative_regulation of TPM1 3 0.57 2.77 0.83 98.20
76 INT4758 Positive_regulation of Localization of Calca 557 0.70 138.55 411.04 98.04
77 INT109246 Gene_expression of Calcrl 16 0.75 4.71 5.19 98.00
78 INT120841 Positive_regulation of Localization of CNTN1 1 0.35 0.52 0.46 98.00
79 INT88008 Positive_regulation of Gene_expression of GDNF 14 0.70 8.9 3.61 97.84
80 INT4449 Positive_regulation of NA 179 0.55 40.26 37.82 97.76
81 INT142735 Regulation of RLS 33 0.53 45.83 11.35 97.70
82 INT14881 Gene_expression of Car3 49 0.73 14.89 9.94 97.66
83 INT6107 Localization of Npy 180 0.81 26.76 81.67 97.66
84 INT124069 Localization of Ntrk1 9 0.59 3.32 1.13 97.64
85 INT109248 Gene_expression of Ramp1 8 0.72 2.45 4.69 97.64
86 INT71787 Positive_regulation of MAPK3 37 0.67 17.5 17.88 97.60
87 INT75742 Binding of RLS 86 0.42 95.27 19.04 97.60
88 INT7465 Negative_regulation of Mbp 53 0.58 19.12 13.27 97.60
89 INT25221 Negative_regulation of FAS-AS1 1 0.42 0.43 1.08 97.56
90 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27 97.36
91 INT120842 Localization of CNTN1 1 0.52 0.52 0.46 97.36
92 INT86648 Binding of SCN11A 2 0.36 1.11 1.4 97.28
93 INT86649 Binding of SCN10A 2 0.36 1.85 1.1 97.28
94 INT142941 Negative_regulation of Scn11a 14 0.43 12.2 13.38 97.28
95 INT124960 Regulation of Scn11a 9 0.52 8.39 5.49 97.28
96 INT100965 Positive_regulation of Nav1 85 0.70 37.74 75.35 97.24
97 INT102101 Positive_regulation of GFRA1 1 0.07 0.35 0.05 97.24
98 INT243708 Gene_expression of Capg 1 0.33 0.69 0.24 97.16
99 INT81495 Positive_regulation of CNR2 28 0.67 14.62 14.27 97.08
100 INT103262 Localization of Nav1 53 0.81 19.23 34.44 96.92
101 INT46833 Positive_regulation of SGSM3 56 0.67 24.49 30.31 96.84
102 INT94450 Gene_expression of Nav1 359 0.78 131.85 275.46 96.80
103 INT110942 Transcription of TRPM8 16 0.69 13.69 1.31 96.40
104 INT60196 Binding of FOS 33 0.47 13.11 6.95 96.36
105 INT113384 Regulation of Gene_expression of Nav1 20 0.62 8.57 16.15 96.16
106 INT243718 Negative_regulation of Gdi1 1 0.03 0.98 0 96.00
107 INT193834 Regulation of Gdi1 2 0.03 0.48 0 96.00
108 INT5591 Regulation of Gene_expression of Fos 425 0.62 129.06 265.78 95.96
109 INT50670 Gene_expression of CPOX 763 0.76 442.13 195.02 95.84
110 INT120433 Regulation of TRPM8 11 0.62 8.56 3.78 95.64
111 INT24079 Positive_regulation of Negative_regulation of Ngf 4 0.50 1.02 1.68 95.60
112 INT39046 Positive_regulation of PTGER1 28 0.69 18.18 13.21 95.56
113 INT181496 Regulation of TRPV4 3 0.23 3.32 3.23 95.20
114 INT67037 Gene_expression of Sod1 121 0.78 59.32 7.99 95.20
115 INT137332 Positive_regulation of Gene_expression of Sod1 41 0.70 19.8 4.69 95.20
116 INT8087 Regulation of Localization of Npy 16 0.45 2.41 6.81 95.16
117 INT181495 Regulation of TRPV3 3 0.25 6.57 4.22 94.92
118 INT9382 Regulation of TRPV1 149 0.62 53.99 77.46 94.64
119 INT243714 Gene_expression of Nhs 2 0.18 1.18 0 94.56
120 INT64849 Gene_expression of Ret 24 0.75 14.36 9.1 94.52
121 INT64171 Regulation of CPOX 109 0.36 55.36 32.96 94.52
122 INT55256 Negative_regulation of Localization of Il6 38 0.58 16.12 13.67 94.32
123 INT3034 Localization of Ngf 126 0.81 50.81 72.84 94.28
124 INT29668 Regulation of PTGER1 9 0.45 5.52 4.5 94.12
125 INT19511 Localization of Il6 212 0.81 118.17 67.67 94.00
126 INT66038 Positive_regulation of Ngfr 32 0.69 26.07 11.75 94.00
127 INT97254 Positive_regulation of Gap43 22 0.46 7.36 4.48 94.00
128 INT6108 Gene_expression of Npy 292 0.78 110.65 148.21 93.92
129 INT8380 Positive_regulation of Gene_expression of Npy 49 0.70 19.62 24.13 93.92
130 INT215864 Localization of Eif2ak3 5 0.75 3.26 1.36 93.80
131 INT5202 Positive_regulation of Gene_expression of Fos 1163 0.70 319.28 684 93.16
132 INT109031 Positive_regulation of Eif2ak3 44 0.69 21.11 14.72 93.12
133 INT91916 Gene_expression of P2rx3 51 0.78 21.2 19.05 92.20
134 INT171666 Regulation of GOPC 117 0.39 40.41 15.47 91.64
135 INT243711 Binding of Park7 3 0.25 1.5 0.06 91.48
136 INT796 Gene_expression of Penk 1902 0.78 275.47 1057.59 90.28
137 INT2780 Regulation of Gene_expression of Penk 265 0.62 32.45 143.88 90.28
138 INT55733 Negative_regulation of VTN 47 0.58 47.22 5.68 90.24
139 INT85640 Gene_expression of Tg(CAG-EGFP)D4Nagy 1138 0.72 311.58 119.18 90.16
140 INT102261 Gene_expression of ANK1 3 0.63 1.05 1.86 90.08
141 INT797 Regulation of Penk 812 0.62 111.13 542.24 90.00
142 INT243717 Positive_regulation of Phosphorylation of Vim 1 0.22 0.47 0.04 89.96
143 INT243716 Phosphorylation of Vim 1 0.26 0.46 0.04 89.96
144 INT88070 Binding of Ema 7 0.18 7.39 0.31 89.88
145 INT50957 Negative_regulation of Il6 134 0.59 79.08 42.67 89.36
146 INT65500 Gene_expression of App 605 0.78 429.94 98.31 89.08
147 INT89662 Positive_regulation of Gene_expression of App 169 0.70 133.36 25.62 89.08
148 INT116321 Regulation of Nav1 38 0.62 26.62 37.97 88.76
149 INT50970 Positive_regulation of Ntrk1 51 0.57 29.38 22.83 88.72
150 INT245532 Negative_regulation of Positive_regulation of Ntrk1 2 0.34 1.56 1.34 88.72
151 INT6056 Negative_regulation of Gene_expression of Fos 601 0.59 193.05 386.84 88.40
152 INT144785 Negative_regulation of Gene_expression of Gtf3a 8 0.12 7.25 2.14 88.32
153 INT21951 Negative_regulation of Gene_expression of GDNF 5 0.43 2.82 1.57 88.32
154 INT57664 Gene_expression of Npy2r 4 0.19 1.41 2.26 87.84
155 INT49147 Gene_expression of Npy1r 27 0.76 6.57 14.75 87.84
156 INT24326 Gene_expression of Ngf 346 0.78 218.67 184.71 86.36
157 INT204973 Positive_regulation of Park7 2 0.23 1.62 0.03 86.24
158 INT203819 Binding of Eif2ak3 9 0.37 5.94 2.57 86.16
159 INT63769 Regulation of Ngf 44 0.62 21.82 25.84 85.96
160 INT12620 Negative_regulation of Negative_regulation of ADCY1 16 0.44 2.98 10.1 85.96
161 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 85.04
162 INT102206 Regulation of Bdnf 37 0.62 28.54 28.78 84.96
163 INT73354 Gene_expression of Gap43 36 0.77 13.74 7.47 84.72
164 INT126504 Regulation of Ntf3 5 0.39 4.3 1.54 84.60
165 INT82882 Localization of Ccl2 61 0.80 41.96 28 84.12
166 INT5966 Localization of Il1a 50 0.78 22.91 26.54 84.12
167 INT79553 Localization of Il12a 9 0.31 5.85 3.16 84.12
168 INT4345 Gene_expression of Gtf3a 157 0.67 80.75 48.47 84.00
169 INT38971 Positive_regulation of Gene_expression of Gtf3a 27 0.60 18.25 7.77 84.00
170 INT76698 Positive_regulation of Pgp 7 0.42 7.37 6.02 83.96
171 INT97870 Positive_regulation of Gene_expression of Ntf3 19 0.70 9.56 7.8 83.88
172 INT20216 Localization of NGF 40 0.80 18.16 16.61 83.84
173 INT152742 Positive_regulation of Localization of NGF 7 0.50 4.44 5.02 83.84
174 INT155476 Regulation of Binding of Vim 2 0.61 0.73 0.29 83.76
175 INT155477 Binding of Vim 13 0.47 2.24 1.12 83.48
176 INT97871 Gene_expression of Ntf3 47 0.78 25.9 15.94 83.28
177 INT92669 Gene_expression of Bdnf 309 0.78 178.26 116.68 83.28
178 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 83.28
179 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 82.96
180 INT50673 Positive_regulation of Gene_expression of CPOX 156 0.54 97.31 37.03 82.76
181 INT528 Gene_expression of Prl 693 0.78 217.18 192.2 81.68
182 INT120844 Negative_regulation of CNTN1 2 0.26 0.52 0.47 81.68
183 INT6490 Negative_regulation of ADCY1 145 0.58 26.25 70.96 81.36
184 INT243710 Binding of Capg 1 0.16 1.21 0.55 81.20
185 INT243707 Positive_regulation of Smarcb1 1 0.45 0.68 0 81.20
186 INT80465 Regulation of Localization of Gucy1a2 1 0.03 0.49 0.23 81.16
187 INT114507 Negative_regulation of Gene_expression of NAV1 17 0.43 7.24 15.93 80.80
188 INT80688 Positive_regulation of Positive_regulation of MAPK1 72 0.69 39.35 14.11 80.64
189 INT80463 Localization of Gucy1a2 4 0.07 0.49 2.5 80.32
190 INT30887 Negative_regulation of Ngf 56 0.59 32.96 20.86 80.00
191 INT5610 Positive_regulation of Insr 140 0.69 37.26 86.24 78.40
192 INT36400 Regulation of SCN10A 7 0.62 2.73 1.97 78.04
193 INT16475 Regulation of GAP43 3 0.44 1.25 1.43 77.72
194 INT34706 Binding of Nfkbiz 2 0.37 0.7 0.11 77.64
195 INT28238 Positive_regulation of Hrct1 5 0.38 3.66 0.5 77.52
196 INT6796 Positive_regulation of Jun 165 0.70 37.18 49.64 75.72
197 INT118440 Gene_expression of TRPV4 20 0.71 7.33 6.01 75.56
198 INT151865 Regulation of TRPA1 5 0.45 2.78 2.7 75.36
199 INT153194 Positive_regulation of Positive_regulation of Nav1 5 0.50 3.44 4.24 75.20
200 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 75.16
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