D:Neurosis

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Disease Term
Synonyms DISORDER NEUROTIC, Disorders Neurotic, NEUROSES, Neurotic, Neurotic Disorder, Neurotic Disorders, Neuroticism, Nonpsychotic Mental Disorder, PSYCHONEUROSES, UNSPECIFIED NEUROTIC DISORDER
Documents 943
Hot Single Events 49
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Neurosis. They are ordered first by their relevance to Neurosis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT277192 SUGT1 Positive_regulation of Gene_expression of SLC6A4 1 0.01 0.86 1.04 88.40
2 INT311616 Binding of MET and Comt 1 0.01 0.2 0.37 75.84
3 INT262370 Binding of GAD1 and GNPTAB 1 0.00 1.36 0 35.56
4 INT235709 Binding of NA and SSR1 1 0.07 0.72 1.08 5.00
5 INT38936 Binding of Avp and Crh 7 0.40 0.82 1.04 5.00
6 INT311612 Binding of Drd2 and Sert1 1 0.12 0.65 0.86 5.00
7 INT304575 Creb1 Regulation of Gene_expression of Bdnf 1 0.04 1 0.84 5.00
8 INT304576 Binding of Arntl and Clock 6 0.37 0.43 0.5 5.00
9 INT304578 Negative_regulation of HDAC9 Positive_regulation of Gene_expression of Bdnf 1 0.06 0.9 0.49 5.00
10 INT304577 Binding of Arntl and Clock Regulation of Gene_expression of Maoa 1 0.01 0.3 0.44 5.00
11 INT267644 Binding of Das and RLS 1 0.06 1.04 0.35 5.00
12 INT247949 Cdk5r1 Positive_regulation of Cdk5 1 0.26 1.12 0.28 5.00
13 INT272618 Positive_regulation of Binding of GAD1 and CEBPZ 1 0.14 0.91 0.25 5.00
14 INT272619 Binding of GAD1 and CEBPZ 1 0.10 0.91 0.25 5.00
15 INT311613 Binding of Slc6a4 and Pten 1 0.24 0.32 0.21 5.00
16 INT342647 Negative_regulation of Binding of Avp and Crh 1 0.37 0.64 0.18 5.00
17 INT247948 Positive_regulation of Cdk5r1 Positive_regulation of Cdk5 1 0.26 0.16 0.07 5.00
18 INT288099 Binding of APP and App 1 0.01 1.04 0.05 5.00
19 INT340502 Agtr1a Negative_regulation of Phosphorylation of Jak2 1 0.12 2.32 0 5.00
20 INT340504 Agtr1a Negative_regulation of Phosphorylation of Pik3cb 1 0.06 1.16 0 5.00
21 INT204927 Binding of LGMN and IL33 1 0.00 0.52 0 5.00
22 INT299889 Binding of MAT1A and MPP6 1 0.03 0.39 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Neurosis. They are ordered first by their pain relevance and then by number of times they were reported in Neurosis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT42980 Gene_expression of GAD1 139 0.69 94.77 45.11 99.62
2 INT11458 Binding of Tap2 3 0.39 2.51 0.57 99.36
3 INT19 Regulation of Gnrhr 131 0.62 36.4 55.66 99.36
4 INT1360 Negative_regulation of Regulation of Gnrhr 5 0.43 0.77 2.86 99.36
5 INT88868 Binding of MCS 45 0.40 37.43 7.98 99.34
6 INT1361 Negative_regulation of Gnrhr 118 0.58 57.77 35.54 98.76
7 INT9973 Binding of MMVP1 14 0.48 22.66 1.79 98.52
8 INT3002 Binding of SUGT1 62 0.24 55.9 14.91 98.48
9 INT4851 Positive_regulation of Chat 53 0.70 9.21 15.11 97.44
10 INT11377 Positive_regulation of Ngf 331 0.70 206.5 238 97.44
11 INT38480 Positive_regulation of Cym 1 0.35 0.52 0.16 95.20
12 INT62630 Positive_regulation of CNR1 86 0.70 40.34 51.51 94.68
13 INT921 Regulation of GH1 172 0.60 52.88 51.04 93.84
14 INT92669 Gene_expression of Bdnf 309 0.78 178.26 116.68 93.60
15 INT106556 Negative_regulation of Gene_expression of Bdnf 42 0.59 34.71 17.64 93.60
16 INT224814 Regulation of EGOT 2 0.17 0.79 0.39 92.96
17 INT1752 Negative_regulation of Ache 109 0.59 42.05 15.73 92.36
18 INT15089 Regulation of SLC6A4 48 0.62 17.87 25.6 91.20
19 INT1215 Negative_regulation of PGE 19 0.47 4.6 1.52 90.72
20 INT756 Gene_expression of C3 138 0.75 100.6 19.2 90.64
21 INT66040 Positive_regulation of Bdnf 114 0.69 67.67 51.81 89.96
22 INT4297 Negative_regulation of CFP 21 0.42 12.7 10.29 88.48
23 INT15091 Gene_expression of SLC6A4 101 0.78 29.91 53.64 88.40
24 INT140670 Negative_regulation of Gene_expression of SLC6A4 4 0.51 2.7 3.88 88.40
25 INT101140 Negative_regulation of Tap1 7 0.50 9.08 17.46 87.76
26 INT189506 Gene_expression of Anxty 32 0.55 45.92 9.11 87.20
27 INT197512 Gene_expression of ABCA4 19 0.75 7.08 0.57 87.12
28 INT205634 Localization of TAS2R20 3 0.21 0.37 0.04 86.80
29 INT13735 Negative_regulation of Regulation of GH1 14 0.42 4.35 5.39 86.60
30 INT249 Localization of GHRH 215 0.80 78.02 51.87 86.36
31 INT254 Regulation of Localization of GHRH 30 0.60 5.17 11.46 86.36
32 INT134346 Binding of PCS 51 0.37 22.27 5.67 85.92
33 INT154358 Transcription of RLS 3 0.59 2.99 0.58 85.52
34 INT52179 Regulation of Lbp 39 0.61 25.4 18.32 84.48
35 INT7581 Binding of ADHD1 132 0.46 135.1 19.73 84.16
36 INT145425 Positive_regulation of NLRP1 19 0.47 6.93 12.09 84.08
37 INT7538 Negative_regulation of IL2 95 0.57 47.31 31.7 83.36
38 INT100427 Binding of SERPINA1 9 0.36 9.63 2.51 83.28
39 INT91991 Negative_regulation of IGKV1-22 2 0.57 2.55 1.67 83.24
40 INT1767 Positive_regulation of PROC 83 0.67 54.14 17 81.96
41 INT91106 Negative_regulation of LTF 9 0.51 5.73 1.09 81.48
42 INT16236 Negative_regulation of CFH 31 0.57 19.59 3.36 80.88
43 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 80.80
44 INT36054 Transcription of IL1B 53 0.72 32.64 17.31 80.80
45 INT36055 Positive_regulation of Transcription of IL1B 9 0.49 6.24 2.21 80.80
46 INT54368 Positive_regulation of VTA1 13 0.59 3.81 8.13 80.48
47 INT252 Localization of GH1 529 0.80 227.4 122.05 80.08
48 INT248 Positive_regulation of Localization of GH1 137 0.69 49.25 32.92 80.08
49 INT984 Positive_regulation of Localization of GHRH 58 0.70 12.66 16.51 80.08
50 INT914 Positive_regulation of GH1 292 0.69 100.7 84.91 79.36
51 INT16234 Positive_regulation of CFH 25 0.50 26.05 3.33 79.32
52 INT957 Positive_regulation of GHRH 136 0.70 36.84 40.52 78.96
53 INT235711 Negative_regulation of Positive_regulation of GNPTAB 1 0.02 0.59 0.15 77.44
54 INT3467 Positive_regulation of Ptger1 28 0.54 10.59 8.93 76.96
55 INT42826 Positive_regulation of Positive_regulation of Ptger1 2 0.28 0.41 0.14 76.96
56 INT57734 Binding of SLC6A4 36 0.48 11.94 15.42 76.84
57 INT53929 Positive_regulation of GNPTAB 12 0.32 6.66 1.4 76.56
58 INT6894 Gene_expression of CNR1 168 0.78 74.07 62.84 74.96
59 INT10444 Positive_regulation of Gene_expression of CNR1 18 0.69 8.69 7.84 74.96
60 INT47681 Regulation of Ntrk2 17 0.62 3.61 6.31 72.96
61 INT3589 Positive_regulation of SCN5A 101 0.57 46.01 21.73 70.48
62 INT8776 Negative_regulation of Positive_regulation of Ache 2 0.43 1.17 0.36 68.76
63 INT101429 Positive_regulation of PST 10 0.40 2.14 0.6 67.60
64 INT8777 Positive_regulation of Ache 25 0.68 7.77 3.18 67.36
65 INT161394 Binding of Mks1 2 0.02 1.52 0.62 66.72
66 INT124126 Regulation of Bas 3 0.23 1.68 1.29 65.52
67 INT42391 Positive_regulation of BCR 7 0.49 4.93 1.44 64.40
68 INT16281 Negative_regulation of Anxty 20 0.48 17.23 4.06 60.48
69 INT62509 Gene_expression of MCS 58 0.67 21.46 6.57 59.40
70 INT109095 Binding of Drd4 7 0.40 3.6 3.18 58.40
71 INT54701 Localization of Ptafr 19 0.49 18.68 3.82 57.92
72 INT200098 Localization of CAPRIN2 2 0.19 0.47 0.05 57.92
73 INT198027 Localization of MCL1 5 0.72 7.46 0.51 57.44
74 INT171476 Negative_regulation of Regulation of HTR1A 1 0.42 1.05 0.52 56.52
75 INT14131 Regulation of HTR1A 34 0.60 9.61 14.74 56.20
76 INT290177 Positive_regulation of Gene_expression of HAL 1 0.11 0.49 0 55.68
77 INT320170 Negative_regulation of YES1 1 0.37 0.17 0.15 54.40
78 INT1829 Gene_expression of CFH 71 0.75 64.24 2.49 54.16
79 INT108710 Gene_expression of HAL 36 0.58 14.75 2.16 54.16
80 INT97984 Negative_regulation of SLC6A4 45 0.59 15.43 18.09 54.04
81 INT148564 Localization of HAL 8 0.68 2.46 0.62 50.96
82 INT290176 Positive_regulation of Localization of HAL 1 0.11 0.55 0 50.96
83 INT19689 Regulation of Tes 5 0.24 1.01 2.76 50.00
84 INT45014 Regulation of IL1RL1 12 0.14 1.87 2.67 49.60
85 INT75742 Binding of RLS 86 0.42 95.27 19.04 44.40
86 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 43.76
87 INT30041 Binding of HAL 8 0.35 2.36 0.95 43.20
88 INT290178 Negative_regulation of Binding of HAL 1 0.09 0.5 0 43.20
89 INT11303 Gene_expression of Avp 116 0.78 39.23 23.88 41.36
90 INT115600 Positive_regulation of Bas 5 0.49 1.89 0.46 37.92
91 INT269798 Regulation of Gene_expression of Anxty 1 0.03 2.05 0.37 36.52
92 INT36148 Binding of GAD1 10 0.41 7.91 1.47 34.48
93 INT205635 Gene_expression of TAS2R20 8 0.19 0.16 0 33.72
94 INT161098 Regulation of Positive_regulation of CNR1 3 0.45 2.22 1.87 30.56
95 INT66039 Positive_regulation of Ntrk2 53 0.69 15.87 17.23 28.72
96 INT278527 Gene_expression of NEO1 1 0.04 1.51 0.13 25.60
97 INT5454 Localization of CRH 124 0.79 79.18 41.53 24.44
98 INT10142 Gene_expression of ANXA3 4 0.35 3.1 0.54 24.20
99 INT6782 Gene_expression of SCN5A 156 0.78 33.13 17.88 24.08
100 INT56053 Negative_regulation of Bdnf 77 0.58 64.4 26.83 23.64
101 INT278526 Positive_regulation of Gene_expression of ANXA3 1 0.08 0.52 0 20.64
102 INT18311 Positive_regulation of CD8A 145 0.69 113.48 19.44 17.44
103 INT36778 Positive_regulation of Anxty 14 0.48 12.85 5.08 15.20
104 INT269797 Positive_regulation of Negative_regulation of Anxty 1 0.03 2.07 0.48 15.20
105 INT166021 Positive_regulation of MCL1 36 0.67 62.97 1.44 14.04
106 INT3364 Binding of SGCG 87 0.47 31.93 17.24 8.84
107 INT2542 Localization of Calca 2008 0.81 518.3 1408.65 5.00
108 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
109 INT7114 Positive_regulation of Ltp 1192 0.62 290.76 755.77 5.00
110 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 5.00
111 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
112 INT5680 Gene_expression of Ngf 530 0.78 264.29 310.56 5.00
113 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
114 INT2909 Positive_regulation of Abat 334 0.70 62.1 256.43 5.00
115 INT738 Regulation of POMC 459 0.62 111.19 243.74 5.00
116 INT9987 Gene_expression of Abat 296 0.78 95.46 226.34 5.00
117 INT1308 Localization of Pomc 457 0.81 66.83 217.5 5.00
118 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
119 INT9132 Negative_regulation of Prkcg 279 0.59 88.05 203.47 5.00
120 INT438 Gene_expression of Crh 376 0.78 159.11 169.17 5.00
121 INT1114 Localization of Ins1 748 0.80 192.95 165.48 5.00
122 INT7628 Gene_expression of Ltp 273 0.77 70.21 147.87 5.00
123 INT1273 Gene_expression of Avp 356 0.78 90.56 138.7 5.00
124 INT4658 Binding of OPRM1 188 0.48 25.96 136.24 5.00
125 INT5497 Positive_regulation of Crh 299 0.70 125.54 131.14 5.00
126 INT65600 Positive_regulation of Casp3 376 0.70 198.44 128.03 5.00
127 INT65054 Positive_regulation of Nfkb1 285 0.70 149.33 126.73 5.00
128 INT1026 Binding of Lbp 207 0.48 150.96 119.16 5.00
129 INT1438 Localization of Pomc 360 0.81 101.26 116.47 5.00
130 INT4207 Regulation of Avp 267 0.62 63.72 115.33 5.00
131 INT47243 Gene_expression of Prkcg 195 0.78 58.05 108.44 5.00
132 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 5.00
133 INT1898 Regulation of Crh 220 0.62 61.33 102.64 5.00
134 INT65500 Gene_expression of App 605 0.78 429.94 98.31 5.00
135 INT3537 Positive_regulation of Car2 413 0.56 103.51 94.35 5.00
136 INT12763 Phosphorylation of Prkcg 167 0.82 38.91 89.63 5.00
137 INT1472 Positive_regulation of Ins1 349 0.69 146.2 86.36 5.00
138 INT16254 Positive_regulation of Gene_expression of Ngf 144 0.70 80.61 82.08 5.00
139 INT7528 Regulation of OPRM1 100 0.62 20.63 80.57 5.00
140 INT19771 Positive_regulation of PAG1 69 0.61 75.61 76.88 5.00
141 INT3657 Gene_expression of Ins1 514 0.78 321.69 75.76 5.00
142 INT12536 Localization of Prkcg 101 0.80 36.37 73.81 5.00
143 INT3034 Localization of Ngf 126 0.81 50.81 72.84 5.00
144 INT5861 Gene_expression of Egr1 203 0.78 49.35 68.13 5.00
145 INT7134 Localization of KNG1 127 0.79 65.73 67.97 5.00
146 INT13286 Gene_expression of Ca2 317 0.67 71.58 65.01 5.00
147 INT18981 Gene_expression of ABAT 78 0.68 38.35 61.36 5.00
148 INT546 Binding of ALB 311 0.48 85.98 60.14 5.00
149 INT102020 Gene_expression of Creb1 190 0.78 57.31 59.77 5.00
150 INT6623 Gene_expression of NA 231 0.78 45.78 59.36 5.00
151 INT1307 Positive_regulation of Localization of Pomc 120 0.70 24.58 58.48 5.00
152 INT82055 Positive_regulation of Creb1 176 0.70 60.2 58.39 5.00
153 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 5.00
154 INT1200 Negative_regulation of Ins1 274 0.58 155.17 56.14 5.00
155 INT2276 Regulation of Ins1 234 0.61 103.78 54.05 5.00
156 INT4345 Gene_expression of Gtf3a 157 0.67 80.75 48.47 5.00
157 INT375 Positive_regulation of REN 293 0.70 152.46 47.55 5.00
158 INT1028 Positive_regulation of Lbp 102 0.69 67.86 46.05 5.00
159 INT2275 Negative_regulation of Localization of Ins1 183 0.59 51.02 44.94 5.00
160 INT49105 Gene_expression of Vcam1 157 0.78 157.27 43.01 5.00
161 INT613 Gene_expression of Alb 268 0.78 149.84 42.78 5.00
162 INT27798 Gene_expression of Ntrk2 111 0.78 56.08 42.68 5.00
163 INT12228 Positive_regulation of Gene_expression of Abat 44 0.65 17.51 40.55 5.00
164 INT30817 Gene_expression of Th 142 0.76 33.56 38.12 5.00
165 INT4449 Positive_regulation of NA 179 0.55 40.26 37.82 5.00
166 INT56870 Gene_expression of CYP2D6 87 0.78 8.83 37.53 5.00
167 INT6417 Negative_regulation of ABAT 49 0.51 19.6 36.81 5.00
168 INT2416 Negative_regulation of MAOA 92 0.59 42.24 36.5 5.00
169 INT18893 Positive_regulation of CPP 81 0.69 38.03 34.33 5.00
170 INT16960 Gene_expression of Crp 166 0.76 116.21 34.07 5.00
171 INT65536 Negative_regulation of Positive_regulation of Nfkb1 77 0.59 38.86 33.33 5.00
172 INT7082 Gene_expression of CRH 180 0.78 64.66 31.74 5.00
173 INT11087 Positive_regulation of Drd2 54 0.69 12.4 31.43 5.00
174 INT29743 Negative_regulation of App 91 0.59 65.56 31.26 5.00
175 INT106554 Positive_regulation of Gene_expression of Bdnf 73 0.70 42.58 30.77 5.00
176 INT1179 Negative_regulation of Ace 157 0.59 67.03 30.46 5.00
177 INT1158 Regulation of Agt 106 0.61 29.4 30.29 5.00
178 INT660 Negative_regulation of REN 194 0.59 82.06 29.46 5.00
179 INT169180 Binding of SNRNP70 204 0.47 119.1 29.3 5.00
180 INT4868 Gene_expression of GAL 75 0.78 22.23 29.02 5.00
181 INT47712 Positive_regulation of App 135 0.69 101.38 28.94 5.00
182 INT9199 Positive_regulation of CEBPZ 111 0.67 30.99 28.45 5.00
183 INT91775 Gene_expression of Slc6a4 102 0.78 26.45 28.23 5.00
184 INT74726 Negative_regulation of Slc6a4 61 0.59 21.01 27.84 5.00
185 INT2408 Regulation of CCK 37 0.61 10.01 26.66 5.00
186 INT70048 Positive_regulation of Gene_expression of IL10 90 0.55 71.34 25.66 5.00
187 INT5622 Gene_expression of Nppa 101 0.78 49.46 25.31 5.00
188 INT57192 Binding of Ltp 43 0.41 17.48 24.96 5.00
189 INT12484 Binding of Drd2 45 0.48 15.17 24.72 5.00
190 INT151758 Gene_expression of PYCARD 91 0.63 14.54 24.27 5.00
191 INT147792 Gene_expression of COPD 230 0.70 287.13 24.1 5.00
192 INT13838 Positive_regulation of Drd1a 48 0.70 9.83 23.42 5.00
193 INT102021 Positive_regulation of Gene_expression of Creb1 66 0.70 24.04 23.28 5.00
194 INT18894 Gene_expression of CPP 44 0.77 23.05 23.05 5.00
195 INT7383 Localization of VIP 53 0.81 17.7 22.65 5.00
196 INT7678 Localization of Alb 142 0.81 80.93 22.49 5.00
197 INT127435 Gene_expression of Per1 89 0.77 13.94 22.31 5.00
198 INT3299 Positive_regulation of AGT 126 0.68 79.45 21.91 5.00
199 INT74682 Positive_regulation of Mmp2 72 0.69 40.46 21.73 5.00
200 INT16396 Negative_regulation of CEBPZ 76 0.48 30.03 21.6 5.00
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