D:Neurosyphilis

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Disease Term
Synonyms Asymptomatic Neurosyphilis, Central Nervous System Syphilis, GENERAL PARALYSES, GENERAL PARALYSIS, GENERAL PARESES, General Paresis, General Paresis Of The Insane, Gummatous Neurosyphilis, JUVENILE NEUROSYPHILIS, Juvenile Pareses, Juvenile Paresis
Documents 99
Hot Single Events 14
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Neurosyphilis. They are ordered first by their relevance to Neurosyphilis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT171264 TNF Positive_regulation of MMP1 2 0.10 2.05 0.95 5.00
2 INT222979 Negative_regulation of Binding of COL1A1 and FN1 1 0.01 1.64 0.93 5.00
3 INT222978 Binding of COL1A1 and FN1 1 0.01 1.64 0.92 5.00
4 INT222988 TNF Positive_regulation of Protein_catabolism of COL1A1 1 0.01 1.66 0.9 5.00
5 INT222985 CP Positive_regulation of Positive_regulation of TGFB1 1 0.00 1.57 0.85 5.00
6 INT222973 NFKBIB Negative_regulation of NFKB2 Negative_regulation of IL6 1 0.00 1.6 0.33 5.00
7 INT222974 NFKBIB Negative_regulation of NFKB2 Negative_regulation of ICAM1 1 0.00 1.6 0.33 5.00
8 INT222976 NFKBIB Negative_regulation of NFKB2 1 0.01 1.58 0.32 5.00
9 INT222986 PTPRC Positive_regulation of SMN1 1 0.01 0.46 0.26 5.00
10 INT222975 PTPRC Positive_regulation of VIM 1 0.05 0.46 0.26 5.00
11 INT222981 TGFB1 Positive_regulation of Gene_expression of MMRN1 1 0.09 1.62 0.25 5.00
12 INT188746 Binding of CSF2 and HIVEP1 1 0.04 3.99 0.21 5.00
13 INT348970 Binding of MOG and HAND1 1 0.03 1.28 0.2 5.00
14 INT222984 TNF Positive_regulation of Positive_regulation of FN1 1 0.05 0.72 0.09 5.00
15 INT188748 AGRP Negative_regulation of CSF2 1 0.05 1.26 0.08 5.00
16 INT348971 Binding of MOG and CARTPT 1 0.06 0.73 0.08 5.00
17 INT188745 AGRP Regulation of Gene_expression of CSF2 1 0.07 1.48 0.08 5.00
18 INT222983 TNF Positive_regulation of Positive_regulation of COL1A1 1 0.01 0.71 0.08 5.00
19 INT222982 TNF Positive_regulation of Localization of FN1 1 0.05 0.56 0.04 5.00
20 INT222980 TNF Positive_regulation of Localization of COL1A1 1 0.01 0.56 0.04 5.00
21 INT222977 Positive_regulation of COL1A1 Positive_regulation of MMP1 1 0.01 0.61 0.03 5.00
22 INT222987 Positive_regulation of COL1A1 Positive_regulation of Protein_catabolism of MMP1 1 0.01 0.61 0.03 5.00
23 INT188747 AGRP Positive_regulation of Gene_expression of CSF2 1 0.06 1.28 0 5.00
24 INT188744 AGRP Regulation of CSF2 1 0.05 1.04 0 5.00
25 INT348972 Binding of CSF2 and MOG 1 0.21 0.41 0 5.00
26 INT188749 Binding of HIVEP1 and ADC 1 0.02 0.92 0 5.00
27 INT174959 Binding of IL6 and Positive_regulation of Transcription of HSP90B2P 1 0.02 0.9 0 5.00
28 INT188750 Binding of CD4 and ADC 1 0.16 0.93 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Neurosyphilis. They are ordered first by their pain relevance and then by number of times they were reported in Neurosyphilis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT80237 Regulation of Copg2as2 1 0.00 0.64 0 100.00
2 INT98411 Gene_expression of TCHH 1 0.01 0.71 0.14 98.52
3 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 98.04
4 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 96.32
5 INT3952 Negative_regulation of ALB 116 0.59 72.18 18.35 95.28
6 INT10709 Negative_regulation of CD4 106 0.59 95.6 14.89 95.28
7 INT75932 Binding of Csf2 45 0.37 33.2 8.01 94.76
8 INT64723 Regulation of Positive_regulation of IL6 13 0.61 12.59 5.19 88.52
9 INT113906 Regulation of Positive_regulation of CCL2 4 0.27 3.2 2.17 88.52
10 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 87.96
11 INT67981 Positive_regulation of CCL2 165 0.70 136.84 61.85 87.60
12 INT56277 Binding of MYH9 3 0.36 2.37 1.11 87.12
13 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 84.76
14 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 84.28
15 INT1126 Negative_regulation of CD79A 46 0.59 31.07 6 79.68
16 INT43907 Binding of CD79A 28 0.48 28.11 3.04 79.24
17 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 75.04
18 INT66281 Transcription of Nos2 81 0.71 39.49 20.37 67.00
19 INT116235 Negative_regulation of Transcription of Nos2 23 0.58 7.91 3.14 67.00
20 INT77435 Positive_regulation of Nos2 343 0.70 208.49 91.43 66.44
21 INT114025 Transcription of Nos1 20 0.70 16.48 15.63 61.12
22 INT145101 Transcription of Nos3 8 0.70 6.04 2.47 61.12
23 INT49171 Gene_expression of Nos1 241 0.78 140.7 104.76 61.12
24 INT65245 Gene_expression of Nos3 121 0.78 98.14 41.56 61.12
25 INT145100 Regulation of Transcription of Nos3 4 0.44 2.05 0.46 61.12
26 INT145099 Regulation of Transcription of Nos1 3 0.44 1.24 0.53 61.12
27 INT121242 Positive_regulation of Gene_expression of Nos3 37 0.69 31.96 12.71 61.12
28 INT145102 Positive_regulation of Transcription of Nos3 1 0.45 0.46 0.14 61.12
29 INT114023 Positive_regulation of Transcription of Nos1 7 0.60 5.35 8.06 60.68
30 INT92837 Negative_regulation of Gene_expression of Nos2 116 0.59 59.67 31.82 49.44
31 INT14737 Gene_expression of FN1 117 0.78 78.74 18.99 49.12
32 INT57273 Positive_regulation of Gene_expression of FN1 26 0.47 17.83 4.2 49.12
33 INT66280 Gene_expression of Nos2 534 0.78 330.78 157.07 48.84
34 INT17275 Gene_expression of HIVEP1 267 0.75 232.07 24.06 48.80
35 INT88700 Gene_expression of CPM 8 0.76 2.55 0.56 48.80
36 INT102658 Negative_regulation of Gene_expression of CSF2 42 0.50 38.63 8.32 42.32
37 INT177968 Negative_regulation of Transcription of CSF2 3 0.37 2.8 0.55 42.32
38 INT348975 Negative_regulation of Transcription of ALB 1 0.04 2.2 0.37 42.32
39 INT163613 Transcription of CSF2 16 0.60 12.98 1.62 39.88
40 INT127291 Transcription of ALB 7 0.67 4.26 0.55 39.60
41 INT77281 Negative_regulation of HIVEP1 132 0.49 102.78 5.36 24.64
42 INT188758 Negative_regulation of CPM 2 0.05 0.89 0 24.64
43 INT88544 Gene_expression of MMRN1 102 0.75 68.8 14.55 20.96
44 INT190208 Positive_regulation of MMRN1 15 0.23 14.1 3.37 20.96
45 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
46 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
47 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
48 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
49 INT55879 Gene_expression of CCL2 421 0.78 240.74 166.02 5.00
50 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 5.00
51 INT12082 Localization of IL6 365 0.81 241.78 105.78 5.00
52 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 5.00
53 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 5.00
54 INT54571 Positive_regulation of NFKB1 263 0.70 138.99 87.32 5.00
55 INT914 Positive_regulation of GH1 292 0.69 100.7 84.91 5.00
56 INT10837 Positive_regulation of Gene_expression of IL8 294 0.70 190.08 70.34 5.00
57 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 5.00
58 INT14740 Gene_expression of TGFB1 272 0.78 168.48 60.18 5.00
59 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87 5.00
60 INT1579 Gene_expression of PRL 279 0.78 119.2 55.41 5.00
61 INT9234 Negative_regulation of Gene_expression of IL6 171 0.59 101.61 53.15 5.00
62 INT9210 Regulation of IL6 166 0.62 125.61 49.95 5.00
63 INT81498 Positive_regulation of Gene_expression of CCL2 107 0.70 53.89 45.22 5.00
64 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 5.00
65 INT65698 Localization of CCL2 118 0.81 77.54 32.69 5.00
66 INT77652 Negative_regulation of Gene_expression of IL8 99 0.59 67.57 30.21 5.00
67 INT86437 Binding of IL6 154 0.48 121.22 29.3 5.00
68 INT14690 Localization of CSF2 124 0.80 85.17 27.26 5.00
69 INT10836 Negative_regulation of IL8 95 0.59 52.59 24.71 5.00
70 INT55170 Gene_expression of NFKB1 97 0.77 52.75 23.04 5.00
71 INT14731 Positive_regulation of TGFB1 78 0.67 52.57 22.23 5.00
72 INT14733 Positive_regulation of Gene_expression of TGFB1 71 0.69 49.89 22.2 5.00
73 INT93663 Positive_regulation of MMP1 72 0.67 33.38 19.86 5.00
74 INT55880 Negative_regulation of Gene_expression of CCL2 49 0.59 22.37 18.09 5.00
75 INT62826 Negative_regulation of Gene_expression of ICAM1 75 0.58 46.39 17.72 5.00
76 INT12081 Localization of TGFB1 64 0.81 35.4 17.47 5.00
77 INT75929 Gene_expression of IL9 61 0.43 24.71 16.17 5.00
78 INT11685 Regulation of CSF2 99 0.59 58.82 15.9 5.00
79 INT102680 Protein_catabolism of COL7A1 49 0.69 34.68 15.78 5.00
80 INT19963 Gene_expression of COL1A1 118 0.59 42.11 15.15 5.00
81 INT22301 Positive_regulation of Gene_expression of CSF2 66 0.63 59.49 14.24 5.00
82 INT2005 Positive_regulation of Gene_expression of PRL 55 0.70 21.4 13.44 5.00
83 INT96850 Negative_regulation of CCL2 42 0.59 24.89 12.55 5.00
84 INT541 Positive_regulation of MBP 31 0.67 28.56 12.24 5.00
85 INT36287 Binding of CD4 96 0.47 58.93 11.88 5.00
86 INT27882 Gene_expression of HSP90B2P 52 0.75 36.51 9.59 5.00
87 INT85418 Positive_regulation of Gene_expression of IL9 11 0.38 11.47 9.56 5.00
88 INT14301 Binding of CSF2 82 0.48 67.95 8.98 5.00
89 INT182229 Positive_regulation of CCL16 15 0.66 12.19 8.21 5.00
90 INT14732 Positive_regulation of FN1 46 0.69 31.17 7.33 5.00
91 INT93664 Gene_expression of TIMP2 33 0.67 36.67 7.14 5.00
92 INT17049 Localization of CD4 57 0.75 35.33 6.89 5.00
93 INT73992 Gene_expression of Hspa1b 41 0.78 37.26 6.88 5.00
94 INT17277 Positive_regulation of Gene_expression of HIVEP1 25 0.67 21.79 6.7 5.00
95 INT22128 Positive_regulation of HIVEP1 61 0.43 70.52 6.07 5.00
96 INT81796 Binding of AGRP 62 0.36 37.19 5.3 5.00
97 INT8959 Binding of Gnb5 17 0.40 31.38 5.1 5.00
98 INT60252 Binding of HIVEP1 59 0.32 65.12 5.06 5.00
99 INT55434 Positive_regulation of Gene_expression of HSP90B2P 14 0.38 10.91 4.83 5.00
100 INT94433 Negative_regulation of TIMP2 16 0.55 9.38 4.78 5.00
101 INT2144 Localization of COL7A1 36 0.74 20.92 4.67 5.00
102 INT55171 Gene_expression of RELA 80 0.75 17.17 4.47 5.00
103 INT19965 Positive_regulation of COL1A1 23 0.45 14.49 4.38 5.00
104 INT141665 Gene_expression of AGRP 83 0.67 43.43 4.24 5.00
105 INT82871 Protein_catabolism of MMP1 13 0.96 10.71 4.09 5.00
106 INT84700 Positive_regulation of HSP90B2P 34 0.67 30.22 4.07 5.00
107 INT88545 Localization of MMRN1 21 0.78 16.67 4.01 5.00
108 INT86998 Regulation of HIVEP1 49 0.44 37.83 4 5.00
109 INT171040 Transcription of CCL16 11 0.68 7.09 3.86 5.00
110 INT151427 Gene_expression of ADC 31 0.55 21.86 3.81 5.00
111 INT98624 Regulation of Aqp4 27 0.62 30.76 3.77 5.00
112 INT12083 Regulation of TGFB1 22 0.53 15.4 3.6 5.00
113 INT170528 Negative_regulation of Gene_expression of CD4 25 0.41 17.98 3.6 5.00
114 INT73991 Positive_regulation of Hspa1b 20 0.69 11.4 3.45 5.00
115 INT111263 Gene_expression of Gnb5 8 0.75 8.51 3 5.00
116 INT19293 Protein_catabolism of FN1 7 0.95 5.15 2.97 5.00
117 INT174958 Negative_regulation of Chuk 21 0.25 8.73 2.96 5.00
118 INT49653 Gene_expression of NFKB2 12 0.61 9.51 2.73 5.00
119 INT62487 Localization of HIVEP1 35 0.73 36.24 2.72 5.00
120 INT59454 Regulation of Gene_expression of CSF2 22 0.52 19.67 2.69 5.00
121 INT17276 Negative_regulation of Gene_expression of HIVEP1 27 0.42 26.85 2.61 5.00
122 INT68091 Localization of COL1A1 19 0.66 9.13 2.56 5.00
123 INT188756 Positive_regulation of AGRP 43 0.60 23.67 2.51 5.00
124 INT15540 Positive_regulation of PDGFA 24 0.47 19.01 2.5 5.00
125 INT97152 Protein_catabolism of COL1A1 11 0.74 8.03 2.3 5.00
126 INT131456 Negative_regulation of MMRN1 14 0.19 9.49 2.29 5.00
127 INT14488 Regulation of MBP 5 0.25 5.17 2.25 5.00
128 INT25265 Transcription of HIVEP1 30 0.45 28.12 2.08 5.00
129 INT173851 Localization of FN1 20 0.76 13.95 1.97 5.00
130 INT213431 Positive_regulation of Gene_expression of MMRN1 15 0.24 9.91 1.96 5.00
131 INT96588 Gene_expression of MOG 18 0.75 11.41 1.89 5.00
132 INT64959 Positive_regulation of Negative_regulation of IL6 5 0.42 5.16 1.86 5.00
133 INT222997 Positive_regulation of Localization of FN1 4 0.14 4.26 1.78 5.00
134 INT91664 Positive_regulation of Negative_regulation of IL8 5 0.40 3.28 1.62 5.00
135 INT110992 Positive_regulation of Positive_regulation of TGFB1 4 0.50 3.01 1.51 5.00
136 INT143716 Phosphorylation of Chuk 16 0.41 5.25 1.35 5.00
137 INT81922 Regulation of Gene_expression of HSP90B2P 5 0.44 4.25 1.34 5.00
138 INT115948 Regulation of Gene_expression of MMRN1 7 0.26 10.37 1.33 5.00
139 INT106445 Gene_expression of PHB2 4 0.74 3.55 1.18 5.00
140 INT156613 Positive_regulation of Positive_regulation of FN1 2 0.45 3.33 1.15 5.00
141 INT203646 Gene_expression of STIP1 26 0.63 23.57 1.14 5.00
142 INT222991 Negative_regulation of Gene_expression of MMRN1 10 0.13 4.39 1.14 5.00
143 INT223004 Regulation of Localization of MMRN1 2 0.13 2.88 1.12 5.00
144 INT199510 Negative_regulation of STIP1 15 0.47 20.99 1.12 5.00
145 INT216858 Negative_regulation of PID1 4 0.35 6.3 1.11 5.00
146 INT156614 Regulation of Gene_expression of COL1A1 6 0.33 2.51 0.99 5.00
147 INT223001 Positive_regulation of Localization of MMRN1 1 0.20 2.18 0.99 5.00
148 INT81794 Regulation of AGRP 12 0.39 4.94 0.9 5.00
149 INT81795 Negative_regulation of AGRP 23 0.41 10.93 0.87 5.00
150 INT156612 Regulation of Gene_expression of FN1 7 0.43 4.44 0.79 5.00
151 INT28774 Localization of LAMC2 6 0.73 3.2 0.76 5.00
152 INT78329 Binding of ADC 7 0.31 7.57 0.73 5.00
153 INT196238 Binding of MOG 4 0.36 4.19 0.73 5.00
154 INT348978 Positive_regulation of MOG 6 0.49 4.2 0.63 5.00
155 INT222996 Negative_regulation of Positive_regulation of MMRN1 1 0.15 1.83 0.62 5.00
156 INT188754 Localization of AGRP 15 0.74 8.88 0.6 5.00
157 INT222998 Positive_regulation of Negative_regulation of CCL2 1 0.12 1.11 0.59 5.00
158 INT320849 Binding of CARTPT 5 0.14 1.85 0.54 5.00
159 INT197024 Binding of STIP1 11 0.35 10.84 0.52 5.00
160 INT188759 Positive_regulation of Gene_expression of ADC 3 0.28 2.7 0.5 5.00
161 INT117796 Binding of CPM 5 0.48 2.79 0.45 5.00
162 INT231129 Positive_regulation of HAND1 5 0.30 2.73 0.45 5.00
163 INT340755 Negative_regulation of CARTPT 2 0.30 2.08 0.4 5.00
164 INT188755 Positive_regulation of Binding of CSF2 6 0.44 8.79 0.35 5.00
165 INT188760 Regulation of ZC3H12A 4 0.04 4.02 0.27 5.00
166 INT231128 Gene_expression of HAND1 4 0.40 1.32 0.25 5.00
167 INT6373 Positive_regulation of AP5M1 2 0.01 1.92 0.22 5.00
168 INT285702 Negative_regulation of Tpmt 2 0.28 1.4 0.19 5.00
169 INT188757 Positive_regulation of Gene_expression of AGRP 12 0.44 5.86 0.13 5.00
170 INT178053 Positive_regulation of STIP1 7 0.44 5.09 0.11 5.00
171 INT348980 Positive_regulation of Gene_expression of MOG 1 0.38 0.69 0.08 5.00
172 INT348977 Positive_regulation of Negative_regulation of CARTPT 1 0.08 0.69 0.08 5.00
173 INT222993 Positive_regulation of Protein_catabolism of MMP1 1 0.10 1.16 0.07 5.00
174 INT348979 Regulation of MOG 1 0.24 1.54 0.06 5.00
175 INT222999 Positive_regulation of Positive_regulation of COL1A1 1 0.04 0.61 0.03 5.00
176 INT222994 Positive_regulation of Localization of COL7A1 2 0.38 0.78 0.03 5.00
177 INT222992 Positive_regulation of Positive_regulation of MMRN1 1 0.15 0.6 0.03 5.00
178 INT304409 Negative_regulation of MOG 2 0.44 0.37 0 5.00
179 INT285279 Positive_regulation of Gene_expression of PHB2 1 0.43 0 0 5.00
180 INT348976 Positive_regulation of CARTPT 1 0.08 0.61 0 5.00
181 INT144201 Transcription of HSP90B2P 2 0.29 0.95 0 5.00
182 INT246981 Gene_expression of DHDDS 2 0.10 0.6 0 5.00
183 INT235713 Binding of PID1 1 0.25 1.41 0 5.00
184 INT203645 Localization of STIP1 2 0.61 2.08 0 5.00
185 INT348974 Transcription of MOG 1 0.60 0.41 0 5.00
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