D:Nicotine Addiction

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pChart

Disease Term
Synonyms Cigar Smoking, Cigarette Smoking, DEPENDENCE NICOTINE, Dependence Tobacco, Disorder Nicotine Use, Disorder Tobacco Use, Nicotine Abstinence, NICOTINE DEPENDENCE, Nicotine Reward, Nicotine Rewarding, Nicotine Use Disorder
Documents 8387
Hot Single Events 200
Hot Interactions 180

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Nicotine Addiction. They are ordered first by their relevance to Nicotine Addiction and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT219686 Binding of CEL and COPD 1 0.12 11.35 1.26 100.00
2 INT219685 Binding of MMP12 and COPD 1 0.27 5.59 0.74 100.00
3 INT341310 Binding of Npc1 and Chdh 1 0.11 7.04 0 100.00
4 INT219684 Binding of MMP12 and GOPC 1 0.09 3.11 0.38 100.00
5 INT219683 Binding of CEL and GOPC 1 0.04 3.11 0.38 100.00
6 INT224410 Binding of CRP and CIMT 3 0.42 10.46 1.2 100.00
7 INT341628 Binding of ADAR and PROC 1 0.03 5.01 0 100.00
8 INT187940 PHGDH Regulation of Gene_expression of RNU105A 1 0.32 0.94 0 100.00
9 INT355103 Binding of Ins2 and Ins1 1 0.12 2 0.21 100.00
10 INT286683 Gopc Positive_regulation of MBD2 1 0.01 1.07 0.11 100.00
11 INT226070 Binding of CRP and MMP9 1 0.51 1.13 0.42 100.00
12 INT240619 Binding of CRP and ADIPOQ 8 0.18 10.74 0.78 100.00
13 INT244349 Binding of GSTM1 and GSTK1 1 0.35 1.22 0 100.00
14 INT308583 Binding of CRP and PLA2G7 1 0.28 1.23 0 100.00
15 INT259638 COPD Positive_regulation of NFE2L2 1 0.03 1.31 0.05 100.00
16 INT262994 Binding of CRP and HSD11B1 1 0.15 3.02 0.03 100.00
17 INT262997 Binding of HSD11B1 and ADIPOQ 1 0.54 2.82 0.07 100.00
18 INT278290 Binding of CRP and PADI4 1 0.11 1.2 0.03 100.00
19 INT308584 Binding of PLA2G7 and ANGPTL5 1 0.02 0.61 0 100.00
20 INT261630 Binding of CPD and NHS 1 0.02 0.69 0.15 99.96
21 INT226073 Binding of CRP and SHBG 2 0.10 2.14 0.24 99.92
22 INT226072 Binding of MMP9 and SHBG 1 0.15 1.02 0.39 99.92
23 INT299261 Dep1 Positive_regulation of Localization of Csf2 1 0.02 0.83 0.21 99.90
24 INT299257 Dep1 Positive_regulation of Localization of Tslp 1 0.03 0.84 0.21 99.90
25 INT353104 Binding of amd and Gtf3a 1 0.01 1.53 0.03 99.84
26 INT192309 Binding of GSTM1 and GSTT1 2 0.43 4.54 0.06 99.78
27 INT201535 Binding of NPC1 and XRCC1 1 0.26 1.6 0.05 99.76
28 INT188964 Binding of AMBP and NAGLU 1 0.01 1.27 0.09 99.62
29 INT229931 Negative_regulation of Binding of C3 and CFH 1 0.08 1.35 0.17 99.62
30 INT278184 Binding of Crp and Hdlcl1 1 0.01 2.72 0.09 99.38
31 INT229928 Binding of C3 and CFH 1 0.07 1.35 0.17 99.36
32 INT261628 Binding of CHRNA3 and MAOA 1 0.22 1.61 0.17 99.24
33 INT178986 Binding of MMP9 and TIMP1 4 0.47 2.58 1.33 99.16
34 INT128986 Binding of CST3 and Phdlc1 1 0.01 1.96 0.22 99.10
35 INT244461 CS Positive_regulation of ESR1 1 0.06 1.15 0.05 99.08
36 INT103000 Cpe Regulation of Penk 1 0.07 0.19 0.62 99.04
37 INT278183 Binding of Crp and Ggt1 1 0.01 1.09 0.04 99.04
38 INT244472 CS Negative_regulation of Binding of XBP1 1 0.19 1.07 0 99.00
39 INT168533 Binding of FSIP1 and Aia1 2 0.01 1.97 0.4 99.00
40 INT344746 GAD1 Regulation of Gene_expression of ABAT 1 0.19 0.75 0.23 98.90
41 INT344747 ABAT Positive_regulation of Gene_expression of MUC1 1 0.04 0.6 0.05 98.88
42 INT261626 Binding of CHRNA5 and MAOA 1 0.22 1.6 0.17 98.80
43 INT71176 Binding of ICAM1 and ITGB2 4 0.21 4.93 1.07 98.80
44 INT286682 Maob Positive_regulation of Positive_regulation of PLEK 1 0.51 0.89 0 98.78
45 INT335457 Binding of SRA1 and hb 1 0.00 1.83 0.37 98.56
46 INT341816 Binding of CEP68 and Aia1 1 0.02 4.76 0.76 98.16
47 INT278164 GSTM1 Positive_regulation of Transcription of GSTP1 1 0.57 0.94 0.07 98.12
48 INT323773 Binding of Il6 and Lep 1 0.29 3.54 0.6 98.12
49 INT221386 Tlr4 Positive_regulation of Gene_expression of IL8 6 0.14 3.53 0.9 98.08
50 INT221385 Tlr4 Positive_regulation of IL8 1 0.05 1.79 0.2 98.08
51 INT299260 Nudc Regulation of Gene_expression of Hspb8 1 0.00 1.61 0.12 98.06
52 INT239041 Binding of Sqle and Gtf3a 1 0.00 1.08 0.27 97.90
53 INT221387 Tlr4 Positive_regulation of Localization of IL8 1 0.05 2.98 0 97.72
54 INT208763 Binding of CSF2 and TPH1 1 0.07 0.65 0.19 97.56
55 INT342584 Binding of HSD11B1 and Shbg 1 0.02 0.72 0 97.48
56 INT336835 Binding of CACNG6 and Aia1 1 0.01 3.41 0.75 97.32
57 INT185384 IRF6 Regulation of Gene_expression of CD14 1 0.04 0.99 0 97.12
58 INT261631 Binding of CYP2A6 and CYP2B6 1 0.18 0.32 0.18 97.04
59 INT240622 Binding of ADIPOQ and Etv3 1 0.04 1.32 0.15 97.00
60 INT331793 Akt1 Positive_regulation of Binding of Ugcg 1 0.02 0.75 0.05 96.76
61 INT342585 Binding of HSD11B1 and Dbp 1 0.05 0.42 0 96.44
62 INT244455 ATF6 Regulation of SIL1 1 0.06 0.69 0 96.40
63 INT244479 CS Positive_regulation of ATF6 1 0.17 1.02 0 96.12
64 INT325027 Apoc3 Negative_regulation of Pnlip 1 0.01 1.02 0.04 95.88
65 INT325026 Apoc3 Negative_regulation of Lpl 1 0.03 1.01 0.04 95.88
66 INT244470 ATF6 Regulation of XBP1 1 0.22 0.69 0 95.76
67 INT261629 Binding of CPD and TRPC5 1 0.04 0.52 0.32 95.60
68 INT104219 SCD Positive_regulation of Cnr1 1 0.00 2.67 2.54 95.60
69 INT104218 SCD Positive_regulation of CNR2 1 0.01 2.67 2.54 95.60
70 INT188789 Binding of pad and Mthfr 1 0.06 4.6 0.31 95.56
71 INT306794 Binding of LEP and COPD 1 0.15 3.94 0.09 95.44
72 INT312692 CCR6 Regulation of CCL20 1 0.29 2.42 0.73 95.36
73 INT212505 Binding of pr and Lbp 1 0.01 4.26 2.62 95.08
74 INT240626 Binding of ADIPOQ and Hdlcl1 1 0.02 3.27 0.28 95.08
75 INT223829 Binding of GSTM1 and GSTP1 2 0.41 2.78 0.39 94.96
76 INT221383 Tlr4 Positive_regulation of Localization of Ptger2 1 0.00 1.78 0.23 94.92
77 INT337762 Tnf Regulation of Gene_expression of Tlr4 1 0.49 1.16 0.18 94.88
78 INT260564 Binding of Nos3 and T2dm2 1 0.05 3.96 0 94.64
79 INT86997 Binding of HIVEP1 and NGF 2 0.03 1.75 1.73 94.48
80 INT346957 HDAC9 Positive_regulation of Gene_expression of GSR 1 0.03 1.28 0.27 94.24
81 INT74014 Binding of TSC1 and XRCC1 1 0.02 1.98 0.09 94.12
82 INT74015 Binding of VHL and XRCC1 1 0.07 3.51 0.09 94.12
83 INT196303 Binding of SCN5A and ACCS 1 0.00 1.43 0.18 93.80
84 INT58648 Binding of HSD11B1 and INS 1 0.04 1.65 0.07 93.68
85 INT344397 Binding of Crp and Ucp2 1 0.37 0.46 0 93.48
86 INT342581 Binding of Dbp and Pth 1 0.04 2.12 0.04 92.32
87 INT95730 Binding of CP and SPINK1 2 0.19 5.65 4.02 92.16
88 INT58649 Binding of INS and Serpine1 1 0.01 1.64 0.07 92.16
89 INT174266 TNF Regulation of Gene_expression of F3 1 0.00 3.2 0.33 91.92
90 INT174265 IL18 Regulation of Gene_expression of F3 1 0.00 3.21 0.33 91.92
91 INT289510 Binding of ODF2 and Ezr 1 0.10 0.47 0 91.72
92 INT292893 TNF Regulation of IL8 2 0.27 1.3 0.63 90.80
93 INT267585 TNF Regulation of IL6 2 0.16 2.44 0.37 90.80
94 INT311265 RENBP Regulation of IL8 1 0.03 1.59 0.33 90.80
95 INT311263 RENBP Regulation of TNF 1 0.01 1.59 0.33 90.80
96 INT311266 RENBP Regulation of IL6 1 0.02 1.59 0.32 90.80
97 INT311268 RENBP Regulation of Gene_expression of IL8 1 0.02 1.05 0.24 90.80
98 INT313509 Binding of ALOX5 and SP1 1 0.07 1.51 0.08 90.72
99 INT307698 Binding of Crp and pad 1 0.04 3.71 0.12 90.60
100 INT243056 Binding of LBP and Tlr4 1 0.00 1.11 0.55 90.40
101 INT331796 Akt1 Negative_regulation of Negative_regulation of Pik3r1 1 0.04 0.88 0.08 90.24
102 INT299258 Dep1 Positive_regulation of Hspb8 1 0.00 2.06 0.33 89.92
103 INT337535 HLA-DRB1 Positive_regulation of Trav6-3 1 0.00 1.14 0.04 89.56
104 INT331794 Binding of Ugcg and Regulation of Negative_regulation of Mapk14 1 0.01 1.05 0.11 89.20
105 INT331792 Binding of Ugcg and Regulation of Negative_regulation of gr 1 0.01 1.05 0.11 89.20
106 INT274437 Binding of IRF6 and LIPA 1 0.00 0.09 0 88.76
107 INT210899 Binding of SELE and IGHD1-14 1 0.39 3.31 0.11 88.56
108 INT331798 Regulation of Binding of gr and Hdac2 1 0.02 0.75 0.07 88.00
109 INT331790 Binding of gr and Hdac2 1 0.01 0.74 0.07 87.68
110 INT242032 Binding of CRP and RS1 1 0.01 1.92 0 87.44
111 INT189957 Binding of LDHA and Pttg1 1 0.05 0.35 0.08 87.36
112 INT226071 Binding of HSD11B1 and MMP9 1 0.09 0.47 0.19 87.16
113 INT331797 Ugcg Regulation of Negative_regulation of Mapk14 1 0.01 1.03 0.11 86.88
114 INT331795 Ugcg Regulation of Negative_regulation of gr 1 0.01 1.04 0.11 86.88
115 INT199787 gr Regulation of gr Regulation of CYP2C9 1 0.03 0.63 0 86.72
116 INT199801 gr Regulation of CYP2C9 1 0.08 0.63 0 86.72
117 INT337536 Binding of Klrk1 and COPD 1 0.03 3.09 0.09 86.24
118 INT70037 TNF Regulation of IL10 2 0.09 2.11 1.26 86.16
119 INT185381 TNF Regulation of TLR2 2 0.31 1.9 0.41 86.16
120 INT99241 IFNG Regulation of IL1B 2 0.21 1.26 0.14 86.16
121 INT185376 IFNG Regulation of IL10 1 0.01 0.69 0.04 86.16
122 INT185383 IL10 Regulation of TLR2 1 0.06 0.68 0.04 86.16
123 INT185377 IL1B Regulation of CSF2 1 0.02 0.68 0.04 86.16
124 INT185380 IFNG Regulation of CSF2 1 0.03 0.69 0.04 86.16
125 INT185378 IL1B Regulation of TLR2 1 0.04 0.68 0.04 86.16
126 INT185374 CSF2 Regulation of TLR2 1 0.04 0.68 0.04 86.16
127 INT185382 IFNG Regulation of TLR2 1 0.09 0.69 0.04 86.16
128 INT185387 TNF Regulation of CSF2 1 0.10 0.69 0.04 86.16
129 INT185375 TNF Regulation of IL1B 1 0.02 0.69 0.04 86.16
130 INT185386 IL10 Regulation of CSF2 1 0.02 0.68 0.04 86.16
131 INT341307 Binding of Sugt1 and Chdh 1 0.00 0.89 0 86.16
132 INT244458 CS Positive_regulation of ERN1 1 0.17 0.71 0 85.60
133 INT272867 Binding of NLRP1 and COPD 1 0.00 1.07 0 85.52
134 INT256605 FPR1 Positive_regulation of MTOR 1 0.01 2.18 0 85.48
135 INT269014 Binding of EGR1 and COPD 1 0.12 0.96 0 85.48
136 INT348321 Binding of POMC and ASPM 1 0.02 0.39 0.23 85.16
137 INT242025 Binding of CRP and CHDH 7 0.18 15.72 0.36 85.08
138 INT271478 Tacr1 Regulation of Binding of Mthfd1 1 0.09 0.48 0.13 84.52
139 INT342580 Binding of Pth and Shbg 1 0.02 0.38 0 84.48
140 INT356199 GOPC Positive_regulation of Acot7 1 0.04 0.33 0.4 84.48
141 INT175399 Binding of TP53 and SACM1L 1 0.00 2.37 0 84.32
142 INT260836 Il18 Positive_regulation of Localization of VEGFA 1 0.06 1.67 0.48 84.28
143 INT260843 Il6 Positive_regulation of Localization of VEGFA 1 0.06 1.67 0.47 84.28
144 INT260838 Il17a Positive_regulation of Localization of VEGFA 1 0.06 1.67 0.47 84.28
145 INT301906 Binding of HMOX1 and HSD11B1 1 0.05 2.41 0 84.28
146 INT315187 Binding of SFRP1 and COPD 1 0.01 4.47 0 83.80
147 INT185388 Binding of PVRL1 and TLR2 1 0.15 0.75 0.04 83.76
148 INT190147 MMP12 Positive_regulation of MMP2 Positive_regulation of Protein_catabolism of MMRN1 1 0.03 0.87 0.9 83.40
149 INT190165 MMP12 Positive_regulation of MMP2 1 0.13 0.72 0.85 83.40
150 INT242034 Positive_regulation of Binding of CRP and CHDH 1 0.18 2.08 0 83.28
151 INT335447 PDX1 Regulation of Gene_expression of COPD 1 0.02 1.03 0.24 82.92
152 INT312802 F2 Positive_regulation of Binding of NPEPPS 1 0.01 1.33 0.32 82.88
153 INT261627 Binding of CPD and SNRNP70 1 0.01 0.36 0.08 82.56
154 INT261625 Binding of CHRNA3 and CPD 1 0.07 0.35 0.08 82.56
155 INT312686 CP Positive_regulation of CP Positive_regulation of CCL20 1 0.03 10.97 2.94 82.48
156 INT312690 CP Positive_regulation of CCL20 1 0.11 8.23 2.2 82.48
157 INT312803 F2 Positive_regulation of NPEPPS 1 0.01 1.32 0.32 82.16
158 INT244450 TMBIM6 Negative_regulation of Gene_expression of ESR1 1 0.04 0.68 0 82.04
159 INT244471 TMBIM6 Negative_regulation of ESR1 1 0.04 0.68 0 82.04
160 INT244451 TMBIM6 Negative_regulation of Gene_expression of XBP1 1 0.13 0.68 0 82.04
161 INT221368 EGFR Regulation of Gene_expression of MUC1 1 0.05 3.82 0.06 81.84
162 INT243119 Binding of amd and Sod2 1 0.29 3.25 0.06 81.72
163 INT331791 Akt1 Negative_regulation of Hdac2 1 0.03 0.8 0.07 81.44
164 INT342232 Binding of POR and SEPP1 1 0.02 0.75 0.08 81.08
165 INT342231 Binding of SEPP1 and ARC 1 0.04 3.84 0.08 81.08
166 INT335446 Binding of PDX1 and COPD 1 0.02 1.99 0.3 81.00
167 INT263180 Binding of PDE5A and COPD 1 0.01 1 0.15 80.96
168 INT263179 PDE3A Regulation of COPD 1 0.00 1 0.15 80.96
169 INT263178 Binding of PDE7A and COPD 1 0.01 1 0.15 80.96
170 INT263177 Binding of PDE3A and COPD 1 0.01 1 0.15 80.96
171 INT263174 PDE7A Regulation of COPD 1 0.01 1 0.15 80.96
172 INT263176 Binding of PDE4A and COPD 1 0.01 1 0.15 80.96
173 INT263175 PDE5A Regulation of COPD 1 0.00 1 0.15 80.96
174 INT180984 IRF6 Positive_regulation of Localization of IL8 7 0.11 2.13 3.47 80.56
175 INT329341 UCN2 Positive_regulation of THAS 1 0.00 1.12 0 80.40
176 INT312691 CCR6 Regulation of PCA 1 0.20 2.76 0.74 80.36
177 INT344748 NFKB2 Regulation of Gene_expression of GAD1 1 0.07 0.87 0.33 80.28
178 INT337537 Binding of MICA and Positive_regulation of Klrk1 1 0.07 0.68 0 80.24
179 INT299262 Dep1 Positive_regulation of Gene_expression of Il4 1 0.03 0.82 0.13 80.16
180 INT329340 UCN2 Positive_regulation of SOD1 1 0.02 1.12 0 80.08
181 INT259670 CSE Positive_regulation of Hmox1 1 0.06 0.97 0 80.00
182 INT301178 UCP2 Negative_regulation of ROS1 1 0.29 1.41 0 79.76
183 INT335492 CREM Positive_regulation of Transcription of HMOX1 1 0.00 0.9 0.03 79.36
184 INT180983 IRF6 Regulation of Localization of IL8 1 0.06 0.38 0.08 79.32
185 INT353106 Binding of amd and C3 1 0.09 1.69 0 78.64
186 INT140813 Binding of Retn and Adipoq 1 0.03 1.18 0.06 78.20
187 INT197547 Binding of PTS and KEAP1 1 0.08 1.23 0 78.20
188 INT319223 RS1 Regulation of Positive_regulation of FSIP1 1 0.05 0.42 0.05 78.04
189 INT350169 Binding of DMD and MRI1 1 0.11 3.08 0.54 77.80
190 INT350168 Binding of DMD and PROC 1 0.00 0.67 0 77.76
191 INT259623 Binding of Eln and Elane 1 0.02 1.38 0.23 77.52
192 INT184814 NOS3 Positive_regulation of Gene_expression of NOS1 1 0.09 0.54 0.1 77.40
193 INT301097 Binding of MECP2 and SNRNP70 1 0.01 1.15 0 77.36
194 INT342647 Negative_regulation of Binding of Avp and Crh 1 0.37 0.64 0.18 77.36
195 INT278295 DBP Positive_regulation of SHBG 1 0.02 0.92 0 77.20
196 INT281005 Hdlcl1 Regulation of OTOR 1 0.00 1.62 0.26 77.20
197 INT38936 Binding of Avp and Crh 7 0.40 0.82 1.04 77.00
198 INT314756 IL6 Positive_regulation of Gene_expression of Crp 2 0.13 4.58 0.48 76.64
199 INT188968 Binding of MT1F and Alb 1 0.00 0.45 0 76.60
200 INT209131 Binding of Bcl2a1a and Drd2 1 0.22 0.45 0.62 76.48

Single Events

The table below shows the top 200 pain related interactions that have been reported for Nicotine Addiction. They are ordered first by their pain relevance and then by number of times they were reported in Nicotine Addiction. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT147792 Gene_expression of COPD 230 0.70 287.13 24.1 100.00
2 INT10918 Gene_expression of ITGB2 93 0.76 71.8 16.34 100.00
3 INT42980 Gene_expression of GAD1 139 0.69 94.77 45.11 100.00
4 INT125312 Positive_regulation of COPD 134 0.59 162.55 20.27 100.00
5 INT190204 Positive_regulation of Gene_expression of MMP12 22 0.67 31.31 13.69 100.00
6 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 100.00
7 INT1026 Binding of Lbp 207 0.48 150.96 119.16 100.00
8 INT100861 Binding of CRP 179 0.48 175.2 26.45 100.00
9 INT56448 Regulation of ICAM1 52 0.60 55.1 10.96 100.00
10 INT60170 Localization of Htr5b 1 0.73 9.57 0.83 100.00
11 INT9664 Binding of LBP 127 0.48 94.9 63.42 100.00
12 INT70970 Binding of COPD 144 0.42 180.34 18.29 100.00
13 INT29561 Binding of GSTM1 35 0.48 25.86 6.24 100.00
14 INT18981 Gene_expression of ABAT 78 0.68 38.35 61.36 100.00
15 INT63341 Negative_regulation of ICAM1 42 0.59 30.45 9.5 100.00
16 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 100.00
17 INT185398 Negative_regulation of Gene_expression of TLR2 34 0.55 27.21 4.73 100.00
18 INT22708 Gene_expression of MUC1 297 0.78 232.71 24.19 100.00
19 INT192311 Binding of GSTT1 7 0.48 10.62 0.12 100.00
20 INT286669 Protein_catabolism of Htr5b 1 0.08 5.12 0.27 100.00
21 INT6852 Localization of TNF 883 0.81 705.95 270.84 100.00
22 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 100.00
23 INT353394 Gene_expression of NFYC 1 0.37 4.8 1.4 100.00
24 INT106971 Positive_regulation of Gene_expression of GAD1 19 0.58 10.89 4.59 100.00
25 INT9660 Regulation of TNF 363 0.62 312.94 139.99 100.00
26 INT62826 Negative_regulation of Gene_expression of ICAM1 75 0.58 46.39 17.72 100.00
27 INT46886 Positive_regulation of Maoa 12 0.69 5.29 5.9 100.00
28 INT156170 Binding of NFYC 3 0.21 4.84 0.91 100.00
29 INT81688 Binding of ras 32 0.41 30.13 4.02 100.00
30 INT187950 Binding of RNU105A 7 0.47 3.31 0.18 100.00
31 INT56364 Regulation of Gene_expression of ITGAM 19 0.61 9.82 5.09 100.00
32 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 100.00
33 INT101723 Positive_regulation of NFYC 3 0.28 3.51 1.53 100.00
34 INT615 Regulation of Alb 66 0.62 33.43 15.33 100.00
35 INT179686 Regulation of Gene_expression of COPD 10 0.34 14.1 1.52 100.00
36 INT76713 Regulation of Gene_expression of PECAM1 16 0.40 14.52 2.51 100.00
37 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18 100.00
38 INT22045 Gene_expression of IRF6 158 0.75 58.07 27.81 100.00
39 INT6481 Binding of TNF 624 0.48 510.2 214.82 100.00
40 INT349080 Binding of Rtn1 1 0.32 5.68 3.21 100.00
41 INT173014 Positive_regulation of Gene_expression of MUC5AC 10 0.45 4.82 0.94 100.00
42 INT251 Regulation of INS 398 0.62 232.47 55.04 100.00
43 INT17086 Binding of HSD11B1 84 0.47 122.28 6.16 100.00
44 INT36428 Binding of Chdh 42 0.47 48.04 26.54 100.00
45 INT546 Binding of ALB 311 0.48 85.98 60.14 100.00
46 INT187956 Regulation of RNU105A 1 0.42 2.23 0.1 100.00
47 INT107242 Binding of MMP3 14 0.47 12.06 5.11 100.00
48 INT344758 Regulation of Gene_expression of ABAT 1 0.33 1.61 1.37 100.00
49 INT239016 Binding of Sqle 1 0.01 5.43 1.63 100.00
50 INT117244 Gene_expression of GABBR1 5 0.33 2.19 4.36 100.00
51 INT21132 Gene_expression of GABRB3 36 0.33 11.32 17.61 100.00
52 INT149138 Binding of PDX1 27 0.37 32.62 9.33 100.00
53 INT25356 Positive_regulation of S100A12 18 0.69 17.62 3.38 100.00
54 INT81726 Binding of soc 42 0.42 9.92 1.61 100.00
55 INT68218 Regulation of Positive_regulation of CYP1A1 3 0.45 2.35 0.1 100.00
56 INT9650 Gene_expression of LPA 141 0.75 104.57 29 100.00
57 INT84978 Positive_regulation of CHDH 21 0.50 21.97 0.48 100.00
58 INT178890 Localization of CHDH 12 0.62 15.76 1.49 100.00
59 INT217607 Gene_expression of Dep1 27 0.43 4.99 2.27 100.00
60 INT344762 Gene_expression of GABRG1 1 0.35 1.14 1.91 100.00
61 INT145537 Regulation of Localization of PECAM1 3 0.18 4.86 0.59 100.00
62 INT10863 Positive_regulation of Ldlr 45 0.68 31.06 7.05 100.00
63 INT70958 Binding of NOS3 19 0.37 11.84 3.29 100.00
64 INT344766 Gene_expression of GABRR2 1 0.35 1.07 1.95 100.00
65 INT62546 Positive_regulation of Gene_expression of Icam1 60 0.70 59.52 16.9 100.00
66 INT178888 Gene_expression of CHDH 41 0.65 38.66 2.51 100.00
67 INT55168 Binding of NFKB1 55 0.48 22.94 13.15 100.00
68 INT275648 Positive_regulation of Gene_expression of RNF138 1 0.28 2.37 0.6 100.00
69 INT275638 Positive_regulation of Gene_expression of STEAP3 1 0.42 2.37 0.6 100.00
70 INT275637 Positive_regulation of Gene_expression of MT2A 2 0.28 2.49 0.6 100.00
71 INT37485 Regulation of RAPGEF5 10 0.44 6.64 1.51 100.00
72 INT199774 Positive_regulation of Ephx1 1 0.40 1.63 0 100.00
73 INT275632 Regulation of Gvhd1 1 0.00 1.59 0.3 100.00
74 INT22454 Regulation of Crp 213 0.62 160.67 49.24 100.00
75 INT198616 Gene_expression of Gvhd1 6 0.50 8.06 0.67 100.00
76 INT138980 Binding of PITX2 15 0.47 10.34 0.88 100.00
77 INT73010 Gene_expression of Tmem132a 8 0.77 4.38 8.86 100.00
78 INT43019 Regulation of PHGDH 4 0.26 2.46 1.53 100.00
79 INT353395 Positive_regulation of Gene_expression of NFYC 1 0.28 0.94 0.21 100.00
80 INT267141 Regulation of Binding of PECAM1 2 0.18 3.2 0.32 100.00
81 INT4369 Gene_expression of Ldha 157 0.76 88.12 22.45 100.00
82 INT738 Regulation of POMC 459 0.62 111.19 243.74 100.00
83 INT106031 Binding of Nat2 1 0.44 1.33 0 100.00
84 INT17686 Negative_regulation of Hdl1 72 0.36 81.85 7.74 100.00
85 INT340345 Positive_regulation of Gene_expression of S100A12 1 0.46 1.94 0.34 100.00
86 INT47860 Negative_regulation of Cyp1a2 20 0.57 6.06 10 100.00
87 INT215454 Regulation of amd 4 0.38 8.07 0.29 100.00
88 INT140561 Regulation of Gene_expression of Thpo 3 0.60 2.21 0.87 100.00
89 INT86098 Regulation of Thpo 3 0.44 2.07 0.45 100.00
90 INT162 Regulation of Prl 794 0.62 165.01 322.24 100.00
91 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 100.00
92 INT173208 Binding of CNBP 9 0.25 11.01 1.23 100.00
93 INT62824 Negative_regulation of Positive_regulation of ICAM1 7 0.53 2.94 1.39 100.00
94 INT199776 Negative_regulation of Gene_expression of Ephx1 1 0.51 0.81 0 100.00
95 INT240786 Binding of Bcl2a1c 10 0.18 9.47 0.12 100.00
96 INT303488 Negative_regulation of Positive_regulation of Cyp1a2 1 0.18 0.96 0 100.00
97 INT199783 Regulation of Positive_regulation of Cyp1b1 1 0.39 0.46 0 100.00
98 INT7134 Localization of KNG1 127 0.79 65.73 67.97 100.00
99 INT299252 Regulation of Gene_expression of Dep1 1 0.07 1.43 0.13 100.00
100 INT34952 Regulation of ABAT 28 0.61 6.05 14.39 100.00
101 INT11636 Positive_regulation of SERPINE1 85 0.69 68.73 14.8 100.00
102 INT27100 Binding of Adrb3 10 0.47 3.44 3.07 100.00
103 INT272768 Gene_expression of Nrxn3 5 0.78 4.73 3.31 100.00
104 INT15012 Regulation of Gpi1 18 0.60 11.64 6.91 100.00
105 INT3546 Binding of Oxt 54 0.48 9.75 10.81 100.00
106 INT229748 Negative_regulation of Gene_expression of CHDH 3 0.25 2.63 0 100.00
107 INT47780 Gene_expression of CREM 17 0.74 5.37 2.13 100.00
108 INT310381 Positive_regulation of Gene_expression of Nrxn3 1 0.03 1.19 1 100.00
109 INT251457 Regulation of Gene_expression of Slc25a3 1 0.10 0.19 0.1 100.00
110 INT217685 Negative_regulation of BMI1 7 0.18 6.01 0.82 100.00
111 INT92941 Binding of ASAP1 24 0.39 12.38 1.25 100.00
112 INT5166 Binding of Ldlr 14 0.48 11.95 3.32 100.00
113 INT73252 Positive_regulation of Mthfd1 124 0.59 59.48 18.35 100.00
114 INT211361 Regulation of RENBP 5 0.08 2.8 0.38 100.00
115 INT86411 Negative_regulation of Negative_regulation of TNF 24 0.42 17.6 7.89 100.00
116 INT102251 Positive_regulation of Positive_regulation of Crp 24 0.58 29.62 7.5 100.00
117 INT52962 Binding of ERBB2 77 0.47 50.03 1.49 100.00
118 INT80784 Regulation of BCS1L 9 0.39 7.63 1.47 100.00
119 INT205618 Gene_expression of Renbp 15 0.26 9.26 1.04 100.00
120 INT147098 Gene_expression of ECA1 4 0.15 2.83 0.48 100.00
121 INT52961 Binding of Mki67ip 1 0.01 1.32 0.06 100.00
122 INT298739 Regulation of USE1 3 0.20 1.58 0.04 100.00
123 INT165692 Negative_regulation of RENBP 7 0.20 1.7 0 100.00
124 INT55961 Positive_regulation of Maob 2 0.68 9.39 0.92 99.98
125 INT213887 Gene_expression of MICB 10 0.19 15.33 0.39 99.98
126 INT34590 Gene_expression of ALPP 199 0.75 89.85 15.1 99.98
127 INT2416 Negative_regulation of MAOA 92 0.59 42.24 36.5 99.98
128 INT41689 Gene_expression of PHGDH 11 0.75 6.61 0.28 99.98
129 INT78251 Positive_regulation of LBP 38 0.69 39.98 26.73 99.98
130 INT27222 Gene_expression of ALPPL2 4 0.52 24.57 2.05 99.98
131 INT141125 Regulation of Gene_expression of GAD1 5 0.52 8.81 3.63 99.98
132 INT48222 Positive_regulation of Localization of IL8 123 0.59 78.04 37.2 99.98
133 INT78816 Positive_regulation of Positive_regulation of ICAM1 9 0.68 8.36 1.55 99.98
134 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 99.98
135 INT112435 Positive_regulation of Gene_expression of Trp53bp2 2 0.37 3.48 1.08 99.98
136 INT51055 Positive_regulation of TIMP1 103 0.69 50.07 19.86 99.98
137 INT16960 Gene_expression of Crp 166 0.76 116.21 34.07 99.98
138 INT73720 Positive_regulation of Gene_expression of Ptafr 4 0.42 4.15 1.25 99.98
139 INT49292 Positive_regulation of Cyp1a2 17 0.69 6.16 4.96 99.98
140 INT229940 Positive_regulation of amd 10 0.49 27.97 0.15 99.98
141 INT162372 Positive_regulation of SFTPD 15 0.67 11.8 3.21 99.98
142 INT191925 Positive_regulation of Gene_expression of Hspb8 18 0.68 26.99 0.83 99.98
143 INT89290 Regulation of MUC1 19 0.45 10.4 0.81 99.98
144 INT6726 Positive_regulation of Edn1 118 0.70 65.96 24.07 99.98
145 INT7205 Positive_regulation of HBG1 65 0.69 40.35 6.37 99.98
146 INT141920 Positive_regulation of Trp53bp2 1 0.13 1.56 0.46 99.98
147 INT178987 Positive_regulation of Positive_regulation of TIMP1 5 0.20 2.81 0.83 99.98
148 INT2040 Positive_regulation of CYP2B6 95 0.69 34.3 25.6 99.98
149 INT10899 Positive_regulation of Gene_expression of Edn1 32 0.70 24.88 7.65 99.98
150 INT105724 Positive_regulation of Gene_expression of Ns5atp9 2 0.69 1.59 0.65 99.98
151 INT242922 Positive_regulation of Gene_expression of amd 2 0.43 5.99 0.1 99.98
152 INT8684 Positive_regulation of ANGPTL5 45 0.69 36.29 7.47 99.98
153 INT286672 Positive_regulation of Regulation of Maoa 1 0.46 0.79 0 99.98
154 INT115921 Positive_regulation of AHR 22 0.49 12.03 3.53 99.98
155 INT286676 Positive_regulation of Regulation of Maob 1 0.40 1.32 0.23 99.98
156 INT205920 Regulation of Gene_expression of Helt 4 0.02 1 2.06 99.98
157 INT3400 Positive_regulation of pr 57 0.68 36.9 16.24 99.98
158 INT26167 Positive_regulation of Hrasls 18 0.23 8.67 4.87 99.98
159 INT244283 Negative_regulation of Gene_expression of MAOA 2 0.27 1.7 2.5 99.98
160 INT49993 Positive_regulation of Gene_expression of Il6 149 0.70 88.07 53.78 99.98
161 INT299984 Positive_regulation of Negative_regulation of EPC1 1 0.17 0.68 0.17 99.98
162 INT62630 Positive_regulation of CNR1 86 0.70 40.34 51.51 99.98
163 INT306911 Positive_regulation of Ephx2 4 0.69 5.39 0.63 99.98
164 INT25438 Positive_regulation of Positive_regulation of Pomc 6 0.48 4 2.37 99.98
165 INT143231 Positive_regulation of CRYGD 20 0.49 14.87 3.67 99.98
166 INT87698 Gene_expression of WAS 25 0.58 8.75 11.83 99.98
167 INT81495 Positive_regulation of CNR2 28 0.67 14.62 14.27 99.98
168 INT95330 Gene_expression of Ephx1 4 0.67 6.72 0.7 99.96
169 INT22212 Gene_expression of CYP1A1 34 0.76 10.11 2.77 99.96
170 INT75001 Gene_expression of Cyp1b1 11 0.66 4.23 0.48 99.96
171 INT57922 Gene_expression of CYP2C9 65 0.78 22.24 7.53 99.96
172 INT215301 Binding of PQBP1 9 0.27 10.36 0.59 99.96
173 INT71281 Positive_regulation of Gene_expression of CYP2C9 13 0.62 5.11 1.3 99.96
174 INT38056 Localization of Crp 71 0.78 53.14 17.03 99.96
175 INT96886 Positive_regulation of Gene_expression of CYP1A1 8 0.64 3.15 0.27 99.96
176 INT199770 Positive_regulation of Gene_expression of Cyp1b1 1 0.59 0.86 0 99.96
177 INT10709 Negative_regulation of CD4 106 0.59 95.6 14.89 99.96
178 INT55367 Localization of Dbp 18 0.70 7.43 0.38 99.96
179 INT10915 Gene_expression of ITGAM 164 0.78 92.42 29.78 99.92
180 INT63349 Gene_expression of PECAM1 199 0.75 166.03 36.76 99.92
181 INT44378 Gene_expression of GSTM1 69 0.76 34.61 8.81 99.92
182 INT95616 Gene_expression of Thpo 48 0.78 21.51 5.88 99.92
183 INT199769 Gene_expression of Ugt2a1 1 0.52 2.77 0 99.92
184 INT199761 Gene_expression of Cyp2s1 1 0.61 2.56 0 99.92
185 INT51898 Binding of PECAM1 26 0.36 18.87 4.22 99.92
186 INT199794 Regulation of Gene_expression of GSTM1 4 0.31 1.92 0.05 99.92
187 INT51896 Localization of PECAM1 11 0.47 9.8 1.78 99.92
188 INT261635 Binding of CPD 1 0.07 1.35 0.19 99.92
189 INT1631 Binding of Hdl1 42 0.36 49.22 2.92 99.92
190 INT199777 Regulation of Gene_expression of Ugt2a1 1 0.30 0.73 0 99.92
191 INT100051 Binding of MUC5AC 20 0.32 14.21 1.14 99.92
192 INT8340 Negative_regulation of SHBG 49 0.57 35.96 4.73 99.92
193 INT63340 Positive_regulation of Gene_expression of ICAM1 109 0.70 90.82 20.61 99.90
194 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 99.90
195 INT111890 Binding of MSD 26 0.41 8.05 1.71 99.90
196 INT196469 Negative_regulation of Gene_expression of ALPPL2 1 0.28 3.43 0.1 99.90
197 INT168624 Regulation of Gene_expression of ras 7 0.39 6.49 0.08 99.90
198 INT9372 Negative_regulation of Lbp 86 0.58 46.54 41.71 99.90
199 INT4391 Gene_expression of SERPINA1 47 0.78 41.43 9.7 99.90
200 INT293300 Regulation of Positive_regulation of LIPC 1 0.13 1.6 0.03 99.90
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