D:Night Blindness

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Disease Term
Synonyms Blindness Night, Difficulty Seeing At Night, Nyctalopia, UNSPECIFIED NIGHT BLINDNESS, Vision Loss Night
Documents 47
Hot Single Events 51
Hot Interactions 5

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Night Blindness. They are ordered first by their relevance to Night Blindness and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT301044 Binding of Csn2 and Trpm1 1 0.09 2.17 0.03 100.00
2 INT301046 Binding of BCS1L and Csn2 1 0.01 0.62 0 100.00
3 INT301045 Binding of Csn2 and Grm6 1 0.02 0.51 0 100.00
4 INT301042 Binding of Csn2 and Nyx 1 0.07 0.51 0 100.00
5 INT101551 Binding of CACNA1A and CACNA1F 1 0.07 1.51 0.33 99.30
6 INT301043 P9Ehs1 Regulation of Trpv1 1 0.00 0.06 0.1 55.44
7 INT301041 Grm6 Regulation of Trpv1 1 0.00 0.06 0.1 55.44
8 INT339580 TIMP3 Positive_regulation of ABCA1 1 0.16 0.73 0 54.92
9 INT339586 TIMP3 Positive_regulation of RPE 1 0.16 0.72 0 54.92
10 INT339581 Binding of TIMP1 and TIMP3 1 0.30 0.54 0 47.32
11 INT315030 Binding of Cav1 and Tmie 1 0.03 0.25 0.14 42.16
12 INT315032 Binding of Cav1 and Ryr1 1 0.27 0.2 0.14 40.48
13 INT296277 Binding of Car2 and Kcnip3 5 0.18 1.09 2.06 11.12
14 INT334833 Binding of Drd2 and Ncs1 1 0.05 1.11 0.76 5.00
15 INT334835 Negative_regulation of Binding of Drd2 and Ncs1 1 0.04 0.56 0.38 5.00
16 INT334836 Ncs1 Regulation of Drd2 1 0.02 0.48 0.33 5.00
17 INT334834 Binding of Pick1 and Camkk1 1 0.00 0.5 0.3 5.00
18 INT301782 Binding of Dmd and Utrn 1 0.24 0.15 0.18 5.00
19 INT313023 Binding of Rara and Rxra 1 0.06 0.73 0.17 5.00
20 INT301784 Binding of Dmd and Sntb1 1 0.05 0.36 0.16 5.00
21 INT261690 Binding of GSC and TCF23 1 0.10 0 0.12 5.00
22 INT301783 Binding of Dtna and Sntb1 1 0.01 0.05 0.12 5.00
23 INT212139 Slc4a3 Positive_regulation of Cl 1 0.07 0 0.12 5.00
24 INT301788 Binding of Dmd and Dtna 1 0.09 0.05 0.12 5.00
25 INT212138 Slc4a3 Positive_regulation of Gene_expression of Cl 1 0.07 0 0.12 5.00
26 INT301789 Binding of Sntb1 and Utrn 1 0.03 0.05 0.12 5.00
27 INT223088 Binding of ELF3 and NAGLU 1 0.14 0.84 0.09 5.00
28 INT223089 Binding of IDS and NAGLU 1 0.26 0.72 0.09 5.00
29 INT236531 Binding of Cacna1f and Flna 1 0.08 0 0.07 5.00
30 INT339583 Binding of ABCA1 and RPE 1 0.03 1.38 0.05 5.00
31 INT310674 Positive_regulation of Binding of ARSB and ELF3 1 0.07 2.46 0.05 5.00
32 INT339587 Positive_regulation of Binding of ABCA1 and RPE 1 0.04 1.38 0.05 5.00
33 INT310675 Binding of ARSB and ELF3 1 0.06 2.4 0.05 5.00
34 INT301786 Negative_regulation of Binding of Dmd and Sntb1 1 0.06 0.31 0.04 5.00
35 INT261691 Binding of TFAM and TCF23 1 0.01 0 0.03 5.00
36 INT334837 Binding of Car2 and Ncs1 1 0.07 0 0.03 5.00
37 INT315034 Ass1 Positive_regulation of Cacna1f 1 0.00 0 0.03 5.00
38 INT339582 AMD1 Regulation of C1QTNF5 1 0.07 2 0 5.00
39 INT277555 Clrn1 Regulation of Localization of Pdc 1 0.05 0.7 0 5.00
40 INT315033 Binding of Calm3 and Vsig2 1 0.00 0 0 5.00
41 INT236528 Binding of Cav1 and Flna 1 0.06 0.09 0 5.00
42 INT340379 Binding of Rabep1 and Ocrl 1 0.08 0.62 0 5.00
43 INT340380 Binding of Cfl1 and Clcn4-2 1 0.13 0.82 0 5.00
44 INT227399 Binding of D5Mit424 and Alms1 1 0.01 0.71 0 5.00
45 INT315029 Binding of Calm3 and Cacna1f 1 0.04 0 0 5.00
46 INT191816 Binding of ETFA and TGM2 1 0.01 0.66 0 5.00
47 INT339585 Binding of AMD1 and MDM1 1 0.06 2.02 0 5.00
48 INT243233 Positive_regulation of Ighmbp2 Negative_regulation of Rs1 1 0.11 0.31 0 5.00
49 INT301787 Dtna Regulation of Prkx 1 0.00 0.1 0 5.00
50 INT243235 Ighmbp2 Negative_regulation of Rs1 1 0.11 0.31 0 5.00
51 INT340378 Binding of Cfl1 and Clcn5 1 0.15 0.82 0 5.00
52 INT315035 Binding of NAE1 and Cav1 1 0.01 0.7 0 5.00
53 INT313022 bc Regulation of Bcmo1 1 0.05 0.07 0 5.00
54 INT313024 Acp6 Positive_regulation of Gene_expression of Rbp4 1 0.01 0 0 5.00
55 INT243232 Ighmbp2 Negative_regulation of Ptch1 1 0.02 0.22 0 5.00
56 INT236529 Binding of Om and Flna 1 0.00 0.09 0 5.00
57 INT315031 Binding of Cacna1f and Vsig2 1 0.02 0 0 5.00
58 INT227398 Binding of H2afy and Alms1 1 0.01 1.42 0 5.00
59 INT340377 Binding of Clcn4-2 and Clcn5 1 0.35 0.82 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Night Blindness. They are ordered first by their pain relevance and then by number of times they were reported in Night Blindness. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT167227 Binding of Csn2 1 0.07 1.35 0.14 100.00
2 INT248975 Positive_regulation of Csn2 4 0.10 0.66 1.31 100.00
3 INT276088 Binding of Csn2 2 0.08 0.92 0 100.00
4 INT101552 Binding of CACNA1F 2 0.17 1.95 0.26 99.96
5 INT159614 Gene_expression of Trpm1 13 0.77 9.47 1.25 99.48
6 INT340373 Negative_regulation of Rbp4 1 0.17 1.96 0.16 99.20
7 INT301040 Positive_regulation of NYX 1 0.49 1.11 0.16 98.88
8 INT266213 Positive_regulation of Grm6 2 0.46 1.88 0.16 98.28
9 INT277542 Negative_regulation of Pdc 1 0.03 1.61 0 98.28
10 INT24519 Negative_regulation of ERG 15 0.38 6.98 1.33 98.14
11 INT301036 Binding of Trpm1 1 0.36 0.55 0.23 98.04
12 INT301035 Localization of Trpm1 1 0.80 2.46 0.37 97.96
13 INT301029 Localization of Grm6 1 0.16 1.15 0.14 97.96
14 INT121788 Localization of BCS1L 11 0.73 10.16 1.14 97.96
15 INT301033 Localization of Nyx 1 0.64 0.62 0 97.96
16 INT301031 Positive_regulation of Nyx 1 0.37 0.61 0 97.92
17 INT109124 Positive_regulation of TIMP3 8 0.61 5.57 5.72 97.92
18 INT158485 Gene_expression of Grm6 12 0.71 1.4 0.33 97.68
19 INT301032 Positive_regulation of Trpm1 1 0.46 0.61 0 97.36
20 INT236517 Gene_expression of Cacna1f 8 0.65 5.18 0.77 97.20
21 INT223182 Gene_expression of Nyx 2 0.54 0.84 0 97.12
22 INT157846 Gene_expression of BCS1L 13 0.50 15.89 0.83 94.24
23 INT301039 Positive_regulation of Gene_expression of Trpm1 1 0.46 0.55 0.23 93.16
24 INT67138 Gene_expression of Gc 19 0.31 17.11 4.1 90.16
25 INT100384 Regulation of SNRNP70 24 0.60 11 3.56 89.76
26 INT200750 Gene_expression of Rho 19 0.65 6.52 0.69 89.32
27 INT276414 Binding of Phlda2 1 0.08 1.12 0 89.28
28 INT216104 Positive_regulation of Gene_expression of Dmd 23 0.46 4.52 0.68 88.08
29 INT95696 Gene_expression of Dmd 130 0.68 26.02 5.34 87.72
30 INT276410 Gene_expression of Imraq3 11 0.11 6.31 1.88 87.52
31 INT315028 Regulation of Cav2 2 0.43 0.86 0.54 86.12
32 INT36453 Binding of ABCA1 48 0.45 19.9 10.84 85.92
33 INT122812 Gene_expression of SNRNP70 130 0.75 67 12.5 85.36
34 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 85.36
35 INT233570 Gene_expression of Rbp4 4 0.66 3.4 0.17 85.20
36 INT113865 Binding of CXADR 35 0.46 3.18 1.12 85.12
37 INT212132 Negative_regulation of Slc4a3 1 0.43 1.17 0.3 85.00
38 INT218315 Gene_expression of RBP4 25 0.76 18.19 0.85 84.80
39 INT54565 Binding of SCLC1 12 0.31 20.41 0.81 83.20
40 INT63505 Negative_regulation of F2 18 0.57 7.4 2.2 83.00
41 INT315026 Gene_expression of Csn2 1 0.30 0.24 0.12 82.88
42 INT301028 Regulation of Trpm1 1 0.27 0.76 0.22 82.24
43 INT98621 Regulation of Trpv1 121 0.62 79.24 75.23 82.24
44 INT30170 Gene_expression of Car2 330 0.66 77.26 46.76 82.16
45 INT200754 Gene_expression of Rpe 35 0.51 6.3 0.58 82.04
46 INT277550 Positive_regulation of Gm14374 2 0.49 1.5 0.42 81.96
47 INT277532 Positive_regulation of Positive_regulation of Clrn1 1 0.50 1.44 0 81.96
48 INT277535 Positive_regulation of Positive_regulation of Gm14374 1 0.49 1.44 0 81.96
49 INT277539 Positive_regulation of Clrn1 1 0.50 4.04 0 81.96
50 INT236516 Regulation of Cacna1f 3 0.44 0.23 0 81.16
51 INT277526 Gene_expression of Clrn1 1 0.78 29.02 0.17 80.84
52 INT213648 Phosphorylation of S100A6 2 0.30 1.43 0.36 79.52
53 INT283110 Localization of Dag1 5 0.73 3.14 0.61 76.80
54 INT57902 Localization of RHO 3 0.36 0.77 0.31 76.40
55 INT51869 Negative_regulation of Dmd 24 0.52 10.4 2.18 76.32
56 INT202817 Gene_expression of Dag1 16 0.75 7.82 1.3 76.08
57 INT104912 Gene_expression of Acvr2a 8 0.63 4.48 1.81 76.00
58 INT286082 Positive_regulation of Gene_expression of Acvr2a 1 0.06 1.25 0 76.00
59 INT158484 Localization of P9Ehs1 1 0.04 0.16 0.24 74.28
60 INT112089 Gene_expression of Cav1 73 0.75 23.8 1.97 73.52
61 INT169180 Binding of SNRNP70 204 0.47 119.1 29.3 72.88
62 INT211095 Negative_regulation of Dag1 14 0.57 7.18 1.07 70.64
63 INT243112 Regulation of Rpe 5 0.40 3.14 0.1 68.08
64 INT234281 Binding of Rpe 5 0.10 2.03 0 68.08
65 INT262586 Regulation of Binding of Rpe 2 0.09 1.9 0 68.08
66 INT99119 Gene_expression of Cacna2d3 7 0.65 1.41 2.21 67.56
67 INT212135 Localization of Slc4a3 2 0.73 0.35 0.13 66.96
68 INT301034 Regulation of Olfr624 1 0.01 0.13 0 66.88
69 INT285294 Localization of RCVRN 1 0.01 2.56 0 64.84
70 INT81047 Negative_regulation of SNRNP70 10 0.36 4.37 0.75 64.16
71 INT301038 Localization of Olfr624 1 0.01 0.12 0 63.92
72 INT276408 Positive_regulation of Gene_expression of Imraq3 2 0.07 1.26 0.49 63.68
73 INT334823 Regulation of Ncs1 1 0.26 0.43 0.18 62.96
74 INT262546 Positive_regulation of Binding of Calm3 2 0.11 0.3 0.39 59.36
75 INT340359 Binding of Clcn5 1 0.48 1.91 0 59.32
76 INT134864 Binding of Calm3 20 0.27 1.86 6.86 58.84
77 INT112090 Negative_regulation of Gene_expression of Cav1 8 0.57 3.5 0.78 58.00
78 INT220497 Regulation of Gene_expression of Cav1 4 0.36 1.84 0.18 58.00
79 INT17561 Localization of Car2 303 0.79 60.95 44.52 57.36
80 INT286081 Regulation of Gene_expression of Acvr2a 1 0.05 0.32 0 56.68
81 INT286084 Regulation of Acvr2a 1 0.02 0.32 0 56.04
82 INT204797 Positive_regulation of Gene_expression of Rho 1 0.14 1.11 0 55.12
83 INT277547 Negative_regulation of Gene_expression of Clrn1 1 0.43 1.03 0 55.04
84 INT204236 Gene_expression of Rho 3 0.23 1.26 0.09 54.52
85 INT243220 Binding of Plxna2 1 0.06 0.87 0 54.48
86 INT77877 Regulation of P9Ehs1 13 0.38 3.31 10.04 52.48
87 INT261705 Binding of TCF23 1 0.15 1.09 0.03 52.20
88 INT226575 Regulation of OXER1 2 0.09 0.16 0.23 51.36
89 INT134753 Gene_expression of TIMP3 19 0.68 15.24 0.88 51.20
90 INT189570 Positive_regulation of Gene_expression of TIMP3 3 0.44 1.57 0 51.20
91 INT301037 Regulation of Grm6 1 0.06 0.05 0.1 50.96
92 INT226576 Binding of OXER1 1 0.07 0.05 0.15 50.72
93 INT204801 Regulation of Positive_regulation of Rho 1 0.13 1.25 0 50.60
94 INT204803 Regulation of Binding of Rho 1 0.13 1.15 0 50.60
95 INT310681 Negative_regulation of ARSB 1 0.56 6.95 0.29 50.44
96 INT204799 Binding of Rho 2 0.12 1.2 0.3 50.12
97 INT204802 Positive_regulation of Binding of Rho 1 0.15 1.24 0 50.12
98 INT243222 Gene_expression of Rs1 6 0.78 8.49 0.17 49.28
99 INT243227 Transcription of Rs1 1 0.69 1.79 0 49.28
100 INT313020 Positive_regulation of Regulation of Rorb 1 0.01 0.92 0 48.92
101 INT101959 Regulation of Rorb 10 0.14 5.18 3.17 48.12
102 INT48250 Regulation of Rara 3 0.29 2.47 0.83 48.12
103 INT91398 Regulation of RARA 7 0.59 5.84 0.67 48.12
104 INT315011 Gene_expression of Cacna1d 1 0.57 4.47 0.29 47.44
105 INT315023 Transcription of Cacna1d 1 0.50 0.26 0.13 47.44
106 INT93089 Positive_regulation of Rho 3 0.47 1.17 0.05 47.16
107 INT189564 Binding of TIMP3 4 0.31 2.45 0.17 46.48
108 INT231152 Regulation of Dmd 9 0.47 3.64 0.19 46.28
109 INT25363 Negative_regulation of Trpv1 144 0.59 64.78 75.7 44.36
110 INT8066 Binding of RASGRP1 10 0.36 4.65 0.58 44.24
111 INT55687 Localization of TIMP1 47 0.74 30.24 12.31 41.08
112 INT334831 Binding of CABP1 1 0.36 0.4 0.25 39.68
113 INT248968 Regulation of Csn2 2 0.20 0.09 0.68 39.56
114 INT145253 Negative_regulation of Cav1 9 0.46 3.02 0.15 38.96
115 INT313009 Binding of bc 1 0.06 0.65 0 37.92
116 INT1474 Regulation of Localization of Ins1 132 0.61 25.96 43.07 37.48
117 INT1114 Localization of Ins1 748 0.80 192.95 165.48 36.88
118 INT50444 Negative_regulation of Gene_expression of Alb 11 0.39 7.63 1.06 35.28
119 INT196321 Negative_regulation of Gene_expression of F2 2 0.17 1.48 0.04 35.28
120 INT39516 Gene_expression of Alb 81 0.75 30.08 6.59 34.40
121 INT313014 Positive_regulation of Binding of Htt 2 0.13 0.91 0 34.40
122 INT313012 Positive_regulation of Binding of Bcmo1 1 0.44 0.57 0 34.40
123 INT3656 Positive_regulation of Gene_expression of Ins1 74 0.54 44.94 17.36 34.28
124 INT133858 Negative_regulation of BCS1L 13 0.51 8.65 0.2 34.16
125 INT22839 Gene_expression of F2 31 0.74 15.53 5.56 34.08
126 INT3657 Gene_expression of Ins1 514 0.78 321.69 75.76 33.68
127 INT240992 Negative_regulation of Rho 6 0.20 2.58 0 33.32
128 INT81195 Binding of Bcmo1 17 0.33 1.28 2.45 32.84
129 INT243418 Binding of Htt 14 0.30 5.94 0.44 32.84
130 INT315025 Gene_expression of Cacna1s 3 0.48 2.3 0.18 32.84
131 INT28312 Gene_expression of ABCA1 85 0.72 37.69 9.27 32.72
132 INT109925 Gene_expression of RPE 11 0.65 12.46 0.68 32.72
133 INT231162 Localization of Dmd 6 0.71 2.27 1.07 31.84
134 INT220504 Positive_regulation of Gene_expression of Cav1 11 0.39 6.26 0.43 30.80
135 INT25170 Positive_regulation of Localization of Car2 78 0.67 15.25 11.24 30.72
136 INT170507 Localization of Tmie 27 0.43 6.25 1.31 30.72
137 INT170503 Positive_regulation of Localization of Tmie 11 0.29 3.27 0.61 30.72
138 INT276411 Negative_regulation of Gene_expression of Imraq3 1 0.06 0.28 0 30.32
139 INT31628 Binding of Thy1 2 0.19 0.17 0.26 29.76
140 INT236521 Negative_regulation of Cacna1f 2 0.36 0.07 0.09 29.68
141 INT287027 Gene_expression of Dtna 2 0.20 0.87 0.31 27.28
142 INT144918 Gene_expression of Thy1 5 0.62 4.39 0.06 26.40
143 INT17274 Gene_expression of Got1 11 0.58 3.98 2 25.12
144 INT3537 Positive_regulation of Car2 413 0.56 103.51 94.35 25.00
145 INT17962 Regulation of Car2 124 0.41 33.98 22.71 25.00
146 INT36040 Localization of Itpr3 21 0.70 4.87 7.77 25.00
147 INT277537 Transcription of Clrn1 1 0.72 5.06 0 25.00
148 INT277534 Localization of Clrn1 1 0.81 4.83 0 25.00
149 INT277524 Binding of Clrn1 1 0.37 1.9 0 25.00
150 INT102839 Gene_expression of Pdc 15 0.52 6.3 1.87 24.80
151 INT313016 Positive_regulation of bc 1 0.08 0.35 0 22.60
152 INT313007 Negative_regulation of bc 1 0.07 0.3 0 21.92
153 INT177328 Positive_regulation of CXADR 9 0.48 4.29 2.27 21.84
154 INT170444 Binding of Gopc 172 0.39 45.05 20.71 19.68
155 INT21609 Positive_regulation of RASGRP1 58 0.50 40.78 5.47 18.24
156 INT108761 Localization of Alms1 24 0.70 13.92 3.74 16.24
157 INT60766 Gene_expression of COL4A4 10 0.77 13.46 1.14 16.16
158 INT24225 Gene_expression of Alms1 93 0.62 52.75 16.93 14.96
159 INT204808 Binding of Kcnj11 3 0.04 3.28 0.07 14.84
160 INT76660 Gene_expression of Trpv1 691 0.78 329.46 386.42 8.84
161 INT213647 Gene_expression of F9 10 0.65 6.48 0 6.28
162 INT315024 Positive_regulation of Cacna1f 1 0.41 0.5 0.17 6.20
163 INT260172 Localization of Rpe 11 0.49 3.53 0.12 6.16
164 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
165 INT5379 Gene_expression of Fos 656 0.78 255.5 292.54 5.00
166 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
167 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
168 INT5380 Positive_regulation of Gene_expression of Fos 243 0.70 105.65 131.05 5.00
169 INT64161 Positive_regulation of Prkca 213 0.70 85.06 129.91 5.00
170 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 5.00
171 INT85640 Gene_expression of Tg(CAG-EGFP)D4Nagy 1138 0.72 311.58 119.18 5.00
172 INT170025 Gene_expression of Fig4 588 0.67 183.27 113.32 5.00
173 INT49171 Gene_expression of Nos1 241 0.78 140.7 104.76 5.00
174 INT7944 Positive_regulation of Fos 193 0.70 60.69 98.31 5.00
175 INT9516 Negative_regulation of Gabrg1 149 0.53 27.83 91.02 5.00
176 INT1988 Positive_regulation of Localization of Ins1 254 0.69 59.25 68.37 5.00
177 INT102546 Gene_expression of Ccl2 197 0.78 192.8 67.41 5.00
178 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 5.00
179 INT79093 Positive_regulation of Nos1 101 0.70 46.89 59.61 5.00
180 INT49170 Negative_regulation of Nos1 116 0.59 60.66 58.87 5.00
181 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 5.00
182 INT1200 Negative_regulation of Ins1 274 0.58 155.17 56.14 5.00
183 INT8528 Negative_regulation of Gene_expression of Fos 100 0.59 41.15 55.6 5.00
184 INT82650 Gene_expression of Bcl2 312 0.78 211.71 55.03 5.00
185 INT2276 Regulation of Ins1 234 0.61 103.78 54.05 5.00
186 INT3213 Gene_expression of Ins1 511 0.76 357.59 53.32 5.00
187 INT111051 Negative_regulation of Nav1 64 0.59 25.51 47.27 5.00
188 INT170646 Negative_regulation of Fig4 213 0.37 81.29 46.92 5.00
189 INT2275 Negative_regulation of Localization of Ins1 183 0.59 51.02 44.94 5.00
190 INT170054 Negative_regulation of Gopc 280 0.38 117.89 42.4 5.00
191 INT57442 Phosphorylation of Prkca 98 0.70 31.58 41.04 5.00
192 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 5.00
193 INT8747 Positive_regulation of Ins1 221 0.69 154.28 35.15 5.00
194 INT666 Gene_expression of Jun 124 0.78 54.61 33.67 5.00
195 INT8097 Gene_expression of EGF 122 0.77 75.94 28.47 5.00
196 INT66200 Gene_expression of Gfap 215 0.78 88.04 28.25 5.00
197 INT11014 Phosphorylation of CREB1 72 0.81 26.35 25.64 5.00
198 INT7715 Regulation of Drd2 35 0.62 10.79 22.3 5.00
199 INT34488 Negative_regulation of MMP2 85 0.59 41.98 21.72 5.00
200 INT7535 Negative_regulation of Tlr4 111 0.56 56.84 21.37 5.00
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