D:Nonarteritic Anterior Ischaemic Optic Neuropathy

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Disease Term
Synonyms Anterior Ischemic Optic Neuropathy, ISCHEMIA OPTIC NERVE, Ischemias Optic Nerve, Ischemic Optic Neuropathies, Ischemic Optic Neuropathy, Naion, Nerve Ischemia Optic, Nerve Ischemias Optic, Neuropathies Ischemic Optic, Neuropathy Ischemic Optic, Nonarteritic Anterior Ischemic Optic Neuropathy
Documents 30
Hot Single Events 12
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Nonarteritic Anterior Ischaemic Optic Neuropathy. They are ordered first by their relevance to Nonarteritic Anterior Ischaemic Optic Neuropathy and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT259716 Loxl1 Regulation of Loxl1 1 0.00 1.84 0.08 50.96
2 INT213206 ASAP2 Negative_regulation of PVR 1 0.01 0.44 0.04 5.00
3 INT213207 Negative_regulation of ASAP2 Negative_regulation of PVR 1 0.01 0.45 0.04 5.00
4 INT313871 Pde5a Positive_regulation of Pah 1 0.49 0.97 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Nonarteritic Anterior Ischaemic Optic Neuropathy. They are ordered first by their pain relevance and then by number of times they were reported in Nonarteritic Anterior Ischaemic Optic Neuropathy. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT219219 Gene_expression of Rgc32 9 0.13 7.29 0.85 99.98
2 INT116824 Negative_regulation of Rgc32 21 0.31 21.62 2.46 99.80
3 INT76336 Negative_regulation of PDE5A 192 0.59 112.02 20.09 98.50
4 INT313867 Negative_regulation of Pde6a 1 0.14 1.08 0.14 98.24
5 INT50579 Binding of CYP3A4 84 0.48 17.52 17.45 97.84
6 INT213218 Negative_regulation of USP33 1 0.01 0.92 0.15 94.20
7 INT45444 Binding of VSX1 5 0.30 3.38 0.5 85.52
8 INT3777 Positive_regulation of NARFL 256 0.56 302.43 25.74 84.84
9 INT151122 Positive_regulation of Litaf 7 0.35 3.58 0.92 82.92
10 INT219216 Positive_regulation of Fxc1 2 0.06 1.74 0.1 82.92
11 INT94863 Gene_expression of Litaf 27 0.65 10.21 4.35 80.64
12 INT151127 Regulation of Gene_expression of Litaf 3 0.18 2.1 0.72 80.64
13 INT28929 Negative_regulation of PVR 22 0.57 16.64 1.07 79.76
14 INT213221 Negative_regulation of ASAP2 1 0.01 5.83 0.46 79.76
15 INT211827 Localization of PVR 3 0.61 1.33 0.13 79.76
16 INT213211 Regulation of Localization of PVR 1 0.23 0.78 0.13 79.76
17 INT213212 Localization of ASAP2 1 0.01 0.78 0.13 79.76
18 INT200009 Binding of TFCP2 1 0.04 0.8 0.08 78.00
19 INT259719 Negative_regulation of Regulation of NARFL 1 0.01 1.67 0 77.08
20 INT1982 Regulation of NARFL 119 0.49 116.2 14.35 76.76
21 INT112267 Positive_regulation of Rgc32 10 0.39 8.1 2.09 76.48
22 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 68.80
23 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 61.52
24 INT22454 Regulation of Crp 213 0.62 160.67 49.24 61.16
25 INT2774 Binding of Crp 241 0.48 195.89 44.39 50.40
26 INT37296 Binding of Esr1 117 0.43 62.51 27.33 50.40
27 INT79599 Protein_catabolism of PDE5A 7 1.00 3.16 0.39 30.88
28 INT213222 Negative_regulation of Protein_catabolism of PDE5A 1 0.24 0.65 0.16 30.88
29 INT5307 Regulation of Tnf 87 0.62 78.71 43.4 25.00
30 INT11064 Positive_regulation of NPR1 24 0.49 14.63 4.78 18.40
31 INT151126 Negative_regulation of Gene_expression of Litaf 6 0.32 2.48 1.21 17.44
32 INT95116 Negative_regulation of PDGFA 24 0.57 19.56 1.29 8.80
33 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
34 INT48767 Negative_regulation of NOS1 312 0.59 154.25 90.32 5.00
35 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 5.00
36 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34 5.00
37 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51 5.00
38 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19 5.00
39 INT8904 Positive_regulation of Gene_expression of EDN1 66 0.70 65.4 14.42 5.00
40 INT8629 Positive_regulation of COL7A1 72 0.69 40.66 12.09 5.00
41 INT95207 Negative_regulation of Pde5a 46 0.58 32.01 10.14 5.00
42 INT8786 Negative_regulation of ALDH7A1 27 0.52 12.81 4.76 5.00
43 INT2144 Localization of COL7A1 36 0.74 20.92 4.67 5.00
44 INT19158 Gene_expression of PAH 35 0.65 35.81 3.88 5.00
45 INT61680 Positive_regulation of PVR 23 0.60 23.27 3.86 5.00
46 INT34720 Positive_regulation of SHBG 58 0.69 32.4 3.83 5.00
47 INT73127 Gene_expression of Pde5a 18 0.76 5.25 3.31 5.00
48 INT107514 Positive_regulation of Akr1b1 6 0.70 7.64 3.21 5.00
49 INT9110 Binding of PAH 32 0.41 42.1 3.1 5.00
50 INT42485 Binding of Pah 9 0.35 3.42 3.03 5.00
51 INT92877 Gene_expression of PDE5A 35 0.76 17.1 2.7 5.00
52 INT127458 Positive_regulation of PAH 24 0.58 27.25 2.53 5.00
53 INT25121 Negative_regulation of Positive_regulation of COL7A1 5 0.24 1.32 2.37 5.00
54 INT108422 Binding of Pde5a 11 0.36 3.07 2.07 5.00
55 INT45167 Positive_regulation of ASAP1 32 0.60 17.09 1.84 5.00
56 INT197166 Gene_expression of Cyp4a10 27 0.75 15.63 1.81 5.00
57 INT93350 Binding of Lepr 17 0.05 27.21 1.5 5.00
58 INT197174 Positive_regulation of Gene_expression of Cyp4a10 17 0.67 8.65 1.4 5.00
59 INT73126 Positive_regulation of Gene_expression of Pde5a 3 0.59 0.55 1.31 5.00
60 INT242945 Localization of PDE5A 9 0.75 4.57 1.28 5.00
61 INT79598 Regulation of PDE5A 16 0.60 8.68 1.17 5.00
62 INT110400 Negative_regulation of Pde1b 21 0.50 0.58 1.14 5.00
63 INT103043 Binding of PDE5A 16 0.37 7.79 1.12 5.00
64 INT228770 Gene_expression of amd 16 0.57 21.49 1.05 5.00
65 INT129971 Regulation of PVR 5 0.60 3.96 0.97 5.00
66 INT66485 Negative_regulation of Binding of Pah 2 0.35 1.27 0.83 5.00
67 INT103784 Gene_expression of Cyp2b9 7 0.70 2.38 0.6 5.00
68 INT197662 Negative_regulation of Positive_regulation of SHBG 5 0.39 3.54 0.52 5.00
69 INT127460 Positive_regulation of Gene_expression of PAH 5 0.43 4.3 0.5 5.00
70 INT15569 Negative_regulation of PDE6C 3 0.21 1.24 0.48 5.00
71 INT130372 Transcription of PDE5A 7 0.72 1.93 0.4 5.00
72 INT276012 Gene_expression of Pde1b 8 0.66 0.58 0.32 5.00
73 INT276027 Positive_regulation of Pde1b 7 0.59 0.71 0.32 5.00
74 INT213214 Positive_regulation of ASAP2 1 0.01 4.59 0.31 5.00
75 INT127462 Regulation of PAH 5 0.39 3.35 0.29 5.00
76 INT213215 Gene_expression of SS18L1 2 0.58 3.71 0.29 5.00
77 INT173876 Positive_regulation of Positive_regulation of COL7A1 3 0.25 1.57 0.24 5.00
78 INT213219 Protein_catabolism of ALDH7A1 1 0.14 0.7 0.23 5.00
79 INT313869 Gene_expression of Pah 4 0.63 3.1 0.23 5.00
80 INT274016 Negative_regulation of PDE6A 1 0.03 1.27 0.22 5.00
81 INT213217 Negative_regulation of Binding of PAH 2 0.32 2.03 0.19 5.00
82 INT213220 Regulation of ASAP2 1 0.01 1.73 0.15 5.00
83 INT313864 Negative_regulation of Tdp2 1 0.02 2.14 0.14 5.00
84 INT242922 Positive_regulation of Gene_expression of amd 2 0.43 5.99 0.1 5.00
85 INT313866 Positive_regulation of Positive_regulation of Pah 1 0.41 0.47 0.08 5.00
86 INT313868 Positive_regulation of Pah 2 0.41 0.67 0.08 5.00
87 INT206463 Positive_regulation of Positive_regulation of ASAP1 4 0.41 1.28 0.07 5.00
88 INT213213 Protein_catabolism of PAH 1 0.76 1.5 0.07 5.00
89 INT276000 Negative_regulation of Positive_regulation of Pde1b 2 0.36 0.54 0.06 5.00
90 INT313865 Positive_regulation of Gene_expression of Pah 2 0.47 0.95 0.05 5.00
91 INT213216 Positive_regulation of Gene_expression of PDE5A 2 0.37 2.08 0.04 5.00
92 INT242921 Positive_regulation of Aoc2-ps1 1 0.12 1.82 0.04 5.00
93 INT219218 Positive_regulation of Negative_regulation of Rgc32 3 0.06 2.96 0.03 5.00
94 INT275993 Negative_regulation of Gene_expression of Pde1b 2 0.36 0.53 0.03 5.00
95 INT219217 Negative_regulation of Positive_regulation of Rgc32 1 0.06 0.67 0 5.00
96 INT274268 Localization of OPA2 1 0.12 1.48 0 5.00
97 INT313870 Negative_regulation of Pah 1 0.48 2.33 0 5.00
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