D:Nonsyndromic Deafness

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Disease Term
Synonyms COMPLETE HEARING LOSS AT BIRTH, Congenital Conductive Deafness, Congenital Deafness, Non Syndromic Deafness, Non Syndromic Hearing Loss
Documents 13
Hot Single Events 6
Hot Interactions 3

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Nonsyndromic Deafness. They are ordered first by their relevance to Nonsyndromic Deafness and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT114811 Kcna7 Regulation of KCNQ2 1 0.00 0.69 0.13 97.08
2 INT114810 KCNQ3 Regulation of KCNQ2 1 0.05 0.35 0.06 96.88
3 INT286422 Binding of Cdc42ep5 and Dock4 1 0.01 0.84 0 82.32
4 INT170832 Cftr Regulation of Scnn1a 2 0.16 1.2 0.67 65.00
5 INT286418 Gtf3a Positive_regulation of Akt1 1 0.01 0.45 0.1 5.00
6 INT277555 Clrn1 Regulation of Localization of Pdc 1 0.05 0.7 0 5.00
7 INT289836 BEST1 Positive_regulation of Gene_expression of Car2 1 0.03 0.08 0 5.00
8 INT286415 Binding of Fos and Fosb 1 0.23 0.08 0 5.00
9 INT286420 Binding of Fgf13 and Mapk8ip3 1 0.36 0 0 5.00
10 INT286419 Rbm39 Negative_regulation of Transcription of Fos 1 0.01 0.16 0 5.00
11 INT286417 Rbm39 Negative_regulation of Jun 1 0.00 0.16 0 5.00
12 INT286416 Rbm39 Negative_regulation of Fos 1 0.01 0.16 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Nonsyndromic Deafness. They are ordered first by their pain relevance and then by number of times they were reported in Nonsyndromic Deafness. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT86602 Binding of KCNH2 14 0.36 4.65 2.58 98.80
2 INT51584 Regulation of KCNQ1 10 0.44 3.21 1.84 95.44
3 INT289820 Regulation of Gene_expression of Clcnkb 1 0.07 0.97 0.1 87.36
4 INT289815 Gene_expression of Clcnkb 1 0.10 0.97 0.1 86.32
5 INT223459 Gene_expression of Dock4 2 0.71 1.5 0.16 85.04
6 INT286390 Gene_expression of Cdc42ep5 1 0.02 0.82 0 85.04
7 INT94450 Gene_expression of Nav1 359 0.78 131.85 275.46 75.56
8 INT277546 Negative_regulation of Clrn1 1 0.51 2.42 0 74.72
9 INT5379 Gene_expression of Fos 656 0.78 255.5 292.54 70.52
10 INT289828 Negative_regulation of Bsnd 1 0.07 0.7 0 61.76
11 INT289817 Negative_regulation of Clcnkb 1 0.09 0.7 0 60.88
12 INT123078 Negative_regulation of Kcnj1 2 0.10 0.87 1.09 60.08
13 INT91360 Negative_regulation of Slc12a2 16 0.54 10.46 12.89 59.60
14 INT334578 Binding of SLC26A4 1 0.21 0.83 0 51.44
15 INT50077 Gene_expression of Myb 21 0.66 7.68 1.54 46.80
16 INT289813 Gene_expression of Bsnd 1 0.07 0.49 0 45.84
17 INT286393 Positive_regulation of Myb 2 0.43 0.8 0.03 36.56
18 INT289827 Binding of Clcnkb 1 0.06 0.39 0 29.28
19 INT289831 Binding of Bsnd 1 0.06 0.38 0 27.52
20 INT286381 Positive_regulation of Gene_expression of Myb 1 0.59 1.1 0 25.12
21 INT277526 Gene_expression of Clrn1 1 0.78 29.02 0.17 7.80
22 INT4658 Binding of OPRM1 188 0.48 25.96 136.24 5.00
23 INT5380 Positive_regulation of Gene_expression of Fos 243 0.70 105.65 131.05 5.00
24 INT85640 Gene_expression of Tg(CAG-EGFP)D4Nagy 1138 0.72 311.58 119.18 5.00
25 INT7944 Positive_regulation of Fos 193 0.70 60.69 98.31 5.00
26 INT3537 Positive_regulation of Car2 413 0.56 103.51 94.35 5.00
27 INT1425 Gene_expression of Rbm39 143 0.58 51.32 65.44 5.00
28 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 5.00
29 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34 5.00
30 INT8528 Negative_regulation of Gene_expression of Fos 100 0.59 41.15 55.6 5.00
31 INT106525 Phosphorylation of Akt1 436 0.82 183.81 47.82 5.00
32 INT30170 Gene_expression of Car2 330 0.66 77.26 46.76 5.00
33 INT17561 Localization of Car2 303 0.79 60.95 44.52 5.00
34 INT666 Gene_expression of Jun 124 0.78 54.61 33.67 5.00
35 INT5378 Regulation of Gene_expression of Fos 47 0.60 14.47 26.41 5.00
36 INT57874 Gene_expression of Egr1 113 0.78 68.46 24.95 5.00
37 INT47818 Positive_regulation of Homer1 48 0.70 11.11 24.05 5.00
38 INT105021 Binding of GOPC 187 0.40 60.39 20.38 5.00
39 INT111401 Positive_regulation of Gene_expression of Tg(CAG-EGFP)D4Nagy 134 0.61 34.87 20.15 5.00
40 INT11275 Regulation of Fos 37 0.60 5.79 18.18 5.00
41 INT6782 Gene_expression of SCN5A 156 0.78 33.13 17.88 5.00
42 INT170855 Negative_regulation of GOPC 188 0.38 70.92 15.41 5.00
43 INT25170 Positive_regulation of Localization of Car2 78 0.67 15.25 11.24 5.00
44 INT70816 Negative_regulation of Fos 32 0.58 13 11.18 5.00
45 INT82769 Positive_regulation of Grm1 20 0.00 7.78 9.82 5.00
46 INT75137 Regulation of Akt1 74 0.48 37.89 9.7 5.00
47 INT57876 Positive_regulation of Egr1 46 0.70 25.6 9.41 5.00
48 INT61264 Regulation of Jun 36 0.61 18.42 8.71 5.00
49 INT156396 Localization of Tg(CAG-EGFP)D4Nagy 61 0.55 13.63 8.17 5.00
50 INT64816 Transcription of Jun 31 0.69 16.01 7.64 5.00
51 INT155680 Gene_expression of Slc1a3 22 0.66 6.76 7.23 5.00
52 INT69289 Negative_regulation of Cftr 44 0.57 13.28 6.97 5.00
53 INT32107 Gene_expression of PTPLA 14 0.47 8.06 6.76 5.00
54 INT94649 Gene_expression of Grm1 19 0.77 5.11 6.58 5.00
55 INT11258 Gene_expression of Gnas 58 0.58 21.6 6.33 5.00
56 INT67635 Negative_regulation of Gnas 29 0.04 11.4 6.32 5.00
57 INT86600 Gene_expression of KCNH2 37 0.78 14.88 6.14 5.00
58 INT26585 Gene_expression of Vim 117 0.77 39.97 6 5.00
59 INT27118 Regulation of Binding of OPRM1 10 0.62 1.18 5.97 5.00
60 INT23598 Binding of SCN5A 32 0.40 16 5.35 5.00
61 INT18681 Gene_expression of Thy1 80 0.71 38.8 5.23 5.00
62 INT130300 Gene_expression of Abcc3 14 0.70 5.34 4.96 5.00
63 INT155681 Negative_regulation of Gene_expression of Slc1a3 5 0.36 2.26 4.86 5.00
64 INT117936 Regulation of Gene_expression of Egr1 18 0.60 9.37 4.45 5.00
65 INT47766 Transcription of Fos 25 0.69 8.78 4.42 5.00
66 INT67182 Gene_expression of Tms 10 0.53 5.14 4.29 5.00
67 INT11277 Localization of Fos 22 0.78 6.58 4.19 5.00
68 INT64163 Negative_regulation of Gene_expression of Jun 13 0.58 3.86 4.03 5.00
69 INT86769 Positive_regulation of Gene_expression of Rbm39 11 0.25 5.6 3.8 5.00
70 INT25251 Binding of Fos 19 0.36 7.96 3.73 5.00
71 INT96777 Localization of Pdgfa 12 0.79 5.86 3.52 5.00
72 INT5286 Gene_expression of ANTXR2 46 0.75 21.06 3.41 5.00
73 INT168003 Localization of Fgf2 24 0.80 12.52 3.31 5.00
74 INT136266 Gene_expression of KCNQ1 23 0.64 8.34 3.11 5.00
75 INT123795 Positive_regulation of KCNQ1 13 0.49 3.53 2.65 5.00
76 INT153492 Gene_expression of Gmcl1 44 0.65 15.77 2.56 5.00
77 INT262474 Gene_expression of Aqp6 26 0.77 2.08 2.49 5.00
78 INT96640 Negative_regulation of Gene_expression of Egr1 13 0.43 7.22 2.48 5.00
79 INT74262 Negative_regulation of Egr1 15 0.57 7.51 2.41 5.00
80 INT108710 Gene_expression of HAL 36 0.58 14.75 2.16 5.00
81 INT15243 Regulation of Egr1 19 0.61 7.6 2.13 5.00
82 INT102839 Gene_expression of Pdc 15 0.52 6.3 1.87 5.00
83 INT59790 Binding of BCR 16 0.36 15.34 1.75 5.00
84 INT114734 Localization of ANTXR2 5 0.73 3.28 1.62 5.00
85 INT30039 Negative_regulation of HAL 7 0.42 4.32 1.61 5.00
86 INT108913 Positive_regulation of HAL 10 0.28 5.71 1.59 5.00
87 INT37037 Positive_regulation of ANTXR2 6 0.50 5.75 1.56 5.00
88 INT50010 Negative_regulation of CHR 5 0.42 3.64 1.41 5.00
89 INT52589 Positive_regulation of Gene_expression of SCN5A 14 0.49 3.84 1.33 5.00
90 INT57425 Binding of MYH14 12 0.11 2.33 1.26 5.00
91 INT11203 Gene_expression of BCR 30 0.75 33.49 1.22 5.00
92 INT119827 Gene_expression of PTPN11 31 0.75 24.21 1.22 5.00
93 INT144843 Regulation of Gmcl1 5 0.37 2.76 1.15 5.00
94 INT58174 Gene_expression of Junb 9 0.78 1.38 1.09 5.00
95 INT210571 Gene_expression of KCNE2 7 0.61 2.7 0.97 5.00
96 INT198324 Gene_expression of Rn28s1 5 0.65 1.3 0.96 5.00
97 INT30041 Binding of HAL 8 0.35 2.36 0.95 5.00
98 INT166715 Gene_expression of Sox9 16 0.65 6.39 0.92 5.00
99 INT191831 Positive_regulation of Slc1a3 6 0.49 3.66 0.87 5.00
100 INT167705 Positive_regulation of Clcn2 3 0.46 1.32 0.63 5.00
101 INT148564 Localization of HAL 8 0.68 2.46 0.62 5.00
102 INT166833 Phosphorylation of Proc 5 0.80 3.56 0.51 5.00
103 INT168801 Localization of Egr1 4 0.78 0.7 0.48 5.00
104 INT215807 Gene_expression of Clcn3 5 0.19 3.2 0.48 5.00
105 INT200401 Gene_expression of KCNE1 14 0.57 6.42 0.45 5.00
106 INT277529 Positive_regulation of Gmcl1 5 0.19 3.67 0.42 5.00
107 INT277550 Positive_regulation of Gm14374 2 0.49 1.5 0.42 5.00
108 INT130556 Binding of CACNA1C 3 0.22 1.84 0.4 5.00
109 INT151400 Binding of JAG1 14 0.37 7.96 0.39 5.00
110 INT239084 Localization of KAT2B 4 0.73 3.08 0.36 5.00
111 INT226933 Gene_expression of Rhod 2 0.46 0.2 0.35 5.00
112 INT32509 Positive_regulation of Npc1 6 0.50 2.24 0.33 5.00
113 INT136267 Binding of KCNQ1 3 0.36 3.28 0.28 5.00
114 INT273924 Gene_expression of Jund 2 0.39 0.5 0.26 5.00
115 INT286394 Negative_regulation of Negative_regulation of Fos 2 0.42 1.08 0.26 5.00
116 INT273867 Binding of Jag1 18 0.45 3.14 0.25 5.00
117 INT277530 Binding of Gmcl1 4 0.22 1.27 0.25 5.00
118 INT120425 Binding of Fgf13 2 0.33 0.07 0.24 5.00
119 INT99443 Regulation of Proc 6 0.23 5.28 0.24 5.00
120 INT239610 Localization of KCNQ1 4 0.62 1.47 0.2 5.00
121 INT98016 Protein_catabolism of Pth 2 0.18 2.07 0.18 5.00
122 INT227405 Localization of Pdc 4 0.32 2.87 0.15 5.00
123 INT243966 Binding of Trak2 5 0.34 0 0.15 5.00
124 INT246624 Binding of Abcc3 2 0.00 0.59 0.15 5.00
125 INT239609 Positive_regulation of KCNE2 1 0.40 1.29 0.15 5.00
126 INT161702 Gene_expression of GJB2 3 0.65 2.19 0.14 5.00
127 INT289814 Negative_regulation of Clcn3 1 0.05 2.54 0.14 5.00
128 INT262478 Binding of Clcn3 1 0.06 1.23 0.14 5.00
129 INT286401 Gene_expression of Akt2 8 0.72 1.36 0.13 5.00
130 INT260172 Localization of Rpe 11 0.49 3.53 0.12 5.00
131 INT277541 Gene_expression of Rp1 1 0.62 0.61 0.12 5.00
132 INT229458 Negative_regulation of Gene_expression of Vim 6 0.36 0.45 0.09 5.00
133 INT277528 Negative_regulation of Gene_expression of Grm1 1 0.35 0.19 0.09 5.00
134 INT289823 Positive_regulation of Gene_expression of Clcn3 1 0.06 0.07 0.09 5.00
135 INT107556 Transcription of ANTXR2 2 0.69 0.17 0.09 5.00
136 INT289826 Binding of Clcn2 1 0.25 0.4 0.08 5.00
137 INT289825 Positive_regulation of Aqp6 2 0.21 0.62 0.07 5.00
138 INT289819 Localization of Clcn3 1 0.09 0.25 0.06 5.00
139 INT156113 Gene_expression of CLCF1 3 0.65 0.28 0.06 5.00
140 INT233836 Binding of Mapk7 2 0.17 0.9 0.05 5.00
141 INT198065 Binding of Slc1a3 3 0.30 0 0.05 5.00
142 INT277545 Transcription of Grm1 1 0.57 0.09 0.05 5.00
143 INT242144 Regulation of Rp1 2 0.22 1.13 0.05 5.00
144 INT266290 Positive_regulation of Localization of Tg(CAG-EGFP)D4Nagy 2 0.12 0.4 0.05 5.00
145 INT277525 Transcription of Slc1a3 1 0.59 0.09 0.05 5.00
146 INT286378 Binding of Fosb 1 0.31 0.15 0.04 5.00
147 INT207067 Localization of Akt2 2 0.69 0.59 0.04 5.00
148 INT193687 Gene_expression of TIMM8A 2 0.49 1.27 0.04 5.00
149 INT277552 Gene_expression of Whrn 2 0.57 0.75 0.04 5.00
150 INT277549 Gene_expression of Leprel2 1 0.01 0.19 0.04 5.00
151 INT286411 Binding of Akt2 1 0.34 0.23 0.04 5.00
152 INT277548 Negative_regulation of Gene_expression of Rp1 1 0.34 0.2 0.04 5.00
153 INT289822 Regulation of Gene_expression of Clcn3 1 0.05 0.91 0.04 5.00
154 INT262477 Positive_regulation of Clcn3 2 0.08 0.31 0.03 5.00
155 INT277543 Negative_regulation of Binding of Gmcl1 1 0.16 0.09 0.03 5.00
156 INT289824 Positive_regulation of Transcription of Clcn3 1 0.06 0.16 0.03 5.00
157 INT289829 Transcription of Clcn3 1 0.08 0.16 0.03 5.00
158 INT289834 Positive_regulation of Protein_catabolism of LRP2 1 0.45 0.65 0.03 5.00
159 INT289835 Protein_catabolism of LRP2 1 0.96 0.58 0.03 5.00
160 INT289812 Gene_expression of Ttyh1 1 0.14 0.26 0.03 5.00
161 INT256366 Gene_expression of GJB6 2 0.50 0.8 0 5.00
162 INT277537 Transcription of Clrn1 1 0.72 5.06 0 5.00
163 INT286403 Binding of Mapk10 2 0.16 0 0 5.00
164 INT277540 Negative_regulation of Leprel2 1 0.01 0.09 0 5.00
165 INT286386 Positive_regulation of Akt2 2 0.61 0.45 0 5.00
166 INT239612 Negative_regulation of TDP1 1 0.41 0.8 0 5.00
167 INT286389 Positive_regulation of Fgf13 2 0.42 0.33 0 5.00
168 INT286395 Negative_regulation of Transcription of Mapk8ip3 1 0.55 0 0 5.00
169 INT277534 Localization of Clrn1 1 0.81 4.83 0 5.00
170 INT286374 Positive_regulation of Transcription of Akt2 1 0.64 0 0 5.00
171 INT286383 Transcription of Zmym4 1 0.68 0 0 5.00
172 INT208928 Localization of Myb 2 0.64 0.2 0 5.00
173 INT277547 Negative_regulation of Gene_expression of Clrn1 1 0.43 1.03 0 5.00
174 INT286372 Gene_expression of Zmym4 1 0.73 0.28 0 5.00
175 INT180621 Negative_regulation of Gene_expression of HAL 1 0.05 0 0 5.00
176 INT286398 Positive_regulation of Transcription of Dock4 1 0.46 0 0 5.00
177 INT286409 Binding of Klf9 1 0.35 0 0 5.00
178 INT286375 Positive_regulation of Gene_expression of Akt2 1 0.43 0 0 5.00
179 INT277527 Positive_regulation of Transcription of Clrn1 1 0.47 0.69 0 5.00
180 INT206486 Transcription of Vim 2 0.56 0.06 0 5.00
181 INT286405 Binding of Fosl2 1 0.06 0.08 0 5.00
182 INT286392 Transcription of Usp36 1 0.48 0 0 5.00
183 INT232921 Gene_expression of Krt6b 2 0.65 1.5 0 5.00
184 INT286404 Negative_regulation of Gene_expression of Akt2 1 0.39 0.06 0 5.00
185 INT286414 Transcription of Akt2 1 0.66 0 0 5.00
186 INT286413 Gene_expression of Usp36 1 0.71 0.18 0 5.00
187 INT277551 Regulation of Gene_expression of Clrn1 1 0.45 1.18 0 5.00
188 INT180620 Positive_regulation of Positive_regulation of HAL 1 0.06 0.09 0 5.00
189 INT277533 Regulation of Gene_expression of Rp1 1 0.36 0.64 0 5.00
190 INT286382 Transcription of Trak2 1 0.62 0 0 5.00
191 INT286376 Positive_regulation of Positive_regulation of Akt2 1 0.43 0.17 0 5.00
192 INT286387 Protein_catabolism of Fos 1 0.64 0 0 5.00
193 INT277531 Regulation of Transcription of Clrn1 1 0.45 1.48 0 5.00
194 INT289830 Negative_regulation of Clcn2 1 0.39 0.23 0 5.00
195 INT286400 Transcription of Mapk8ip3 1 0.68 0 0 5.00
196 INT286397 Negative_regulation of Mapk8ip3 1 0.41 0.06 0 5.00
197 INT239613 Positive_regulation of TDP1 1 0.45 0.8 0 5.00
198 INT211945 Negative_regulation of Gene_expression of Sox9 3 0.44 0.63 0 5.00
199 INT286410 Positive_regulation of Transcription of Fgf13 1 0.62 0 0 5.00
200 INT286399 Transcription of Stk3 1 0.64 0 0 5.00
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