D:Normal Pressure Hydrocephalus

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Disease Term
Synonyms HAKIM S SYNDROME, Hakim S Syndromes, Hakim Syndrome, Hakim Syndromes, Hakims Syndrome, Nph Normal Pressure Hydrocephalus, Nphs Normal Pressure Hydrocephalus, Syndrome Hakim, Syndrome Hakim S, Syndromes Hakim, Syndromes Hakim S
Documents 60
Hot Single Events 45
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Normal Pressure Hydrocephalus. They are ordered first by their relevance to Normal Pressure Hydrocephalus and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT257937 Binding of CSF2 and INVS 1 0.04 1.1 0.14 100.00
2 INT355984 PDC Positive_regulation of Gene_expression of IL17A 1 0.06 1.57 0.31 29.16
3 INT355979 Negative_regulation of PDC Positive_regulation of Gene_expression of IL17A 1 0.06 1.57 0.31 29.16
4 INT355982 Binding of HLA-DQA2 and DCPS 1 0.00 1.33 0.26 19.36
5 INT355985 IDO1 Positive_regulation of Gene_expression of DCPS 1 0.02 1.21 0.23 10.24
6 INT355981 IFNAR2 Positive_regulation of IDO1 1 0.01 1.13 0.23 8.36
7 INT149117 Binding of CD80 and CTLA4 31 0.52 12.7 7.73 5.00
8 INT194647 Binding of CD28 and CD80 15 0.40 4.9 3.22 5.00
9 INT186126 Binding of CD28 and CTLA4 9 0.52 4.13 3.12 5.00
10 INT355983 CSF2 Regulation of Gene_expression of DCPS 1 0.02 0.84 0.25 5.00
11 INT279961 CSF2 Negative_regulation of TTR 1 0.04 1.07 0.23 5.00
12 INT279964 STAT3 Regulation of Transcription of FGG 1 0.22 1.37 0.2 5.00
13 INT279965 STAT3 Regulation of Transcription of BCL2L1 1 0.10 2.31 0.19 5.00
14 INT340744 CSF2 Regulation of BDNF 1 0.13 1.45 0.14 5.00
15 INT340742 Positive_regulation of CSF2 Regulation of BDNF 1 0.22 1.46 0.14 5.00
16 INT279962 Binding of A1BG and BCL2L1 1 0.13 1.11 0.1 5.00
17 INT351032 Binding of CD80 and CD96 1 0.01 0.36 0.09 5.00
18 INT351031 Binding of CD28 and CD96 1 0.02 0.36 0.09 5.00
19 INT306560 BMP4 Positive_regulation of MAPK1 1 0.09 0.09 0.03 5.00
20 INT351029 AGK Regulation of VEGFA 1 0.00 0.82 0 5.00
21 INT340743 Negative_regulation of CSF2 Positive_regulation of ZNF807 1 0.00 1.77 0 5.00
22 INT340745 CSF2 Positive_regulation of ZNF807 1 0.00 1.76 0 5.00
23 INT209570 Fig4 Positive_regulation of Gene_expression of Gfap 1 0.40 0.17 0 5.00
24 INT351030 AGK Regulation of ARAF 1 0.00 0.82 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Normal Pressure Hydrocephalus. They are ordered first by their pain relevance and then by number of times they were reported in Normal Pressure Hydrocephalus. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT228298 Gene_expression of INVS 10 0.65 6.44 0.43 100.00
2 INT195203 Binding of Tenc1 14 0.32 13.97 8.28 100.00
3 INT230768 Regulation of INVS 2 0.07 1.36 0 100.00
4 INT214025 Negative_regulation of INVS 4 0.07 3.36 0 100.00
5 INT26972 Negative_regulation of Tenc1 57 0.57 56.71 16.87 100.00
6 INT257940 Gene_expression of HYDIN 1 0.02 1.46 0.31 100.00
7 INT71868 Regulation of Tenc1 9 0.52 10.73 4.09 100.00
8 INT195204 Regulation of Gene_expression of Tenc1 3 0.25 2.37 0.09 100.00
9 INT195202 Negative_regulation of Gene_expression of Tenc1 7 0.24 3.76 0.62 100.00
10 INT26973 Gene_expression of Tenc1 59 0.66 27.19 12 100.00
11 INT110748 Transcription of Tenc1 5 0.30 3.06 0.48 100.00
12 INT111124 Positive_regulation of INVS 3 0.49 0.73 0.27 100.00
13 INT11439 Positive_regulation of Csf2 105 0.69 62.63 37.77 99.58
14 INT14301 Binding of CSF2 82 0.48 67.95 8.98 99.56
15 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 99.46
16 INT105381 Binding of NPFF 4 0.48 1.07 7.48 99.44
17 INT22939 Gene_expression of Csf2 164 0.78 85.1 32.22 99.16
18 INT151123 Negative_regulation of Gene_expression of Csf2 21 0.53 21.76 3.22 99.16
19 INT155052 Regulation of Gene_expression of Csf2 6 0.37 7.75 0.8 99.16
20 INT5843 Positive_regulation of Gfap 184 0.70 108.2 70.21 98.20
21 INT49555 Positive_regulation of Positive_regulation of Gfap 18 0.69 11.51 10.29 98.20
22 INT3521 Regulation of Csf2 38 0.54 11.09 12.73 97.84
23 INT45142 Gene_expression of DCPS 109 0.56 84.71 16.87 97.16
24 INT169628 Binding of SNCA 4 0.47 3.53 0.36 97.16
25 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 97.04
26 INT188760 Regulation of ZC3H12A 4 0.04 4.02 0.27 95.88
27 INT257943 Regulation of Regulation of ZC3H12A 1 0.00 0.97 0.07 95.88
28 INT257941 Negative_regulation of ZC3H12A 1 0.01 0.59 0.05 95.76
29 INT257939 Transcription of CEBPZ 1 0.10 0.93 0.34 95.40
30 INT59454 Regulation of Gene_expression of CSF2 22 0.52 19.67 2.69 95.12
31 INT85147 Positive_regulation of Gene_expression of Tgfb1 12 0.46 7.29 3.24 93.00
32 INT68279 Positive_regulation of Gene_expression of Csf2 30 0.67 16.31 6.88 93.00
33 INT36336 Gene_expression of Tgfb1 41 0.77 21.82 14.53 92.20
34 INT11685 Regulation of CSF2 99 0.59 58.82 15.9 91.76
35 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 91.24
36 INT9945 Negative_regulation of Csf2 35 0.51 17.85 11.22 90.32
37 INT15310 Gene_expression of DLEU1 8 0.67 20.57 0.96 90.00
38 INT63133 Gene_expression of Pd 13 0.18 5.31 0.61 90.00
39 INT153326 Binding of ETV1 2 0.29 1.25 0.11 89.64
40 INT61548 Positive_regulation of Fgf2 72 0.70 32.18 14.49 89.24
41 INT257938 Binding of HYDIN 1 0.01 3.74 0.39 87.36
42 INT246551 Negative_regulation of Serpinb12 1 0.01 2.57 0.17 85.84
43 INT3793 Regulation of CEBPZ 59 0.61 20.91 15.83 84.36
44 INT340751 Binding of DLEU1 1 0.20 12.05 0.49 84.32
45 INT257942 Regulation of ETV1 1 0.01 1.26 0.11 80.56
46 INT154303 Negative_regulation of DCPS 27 0.36 33.83 5.45 78.64
47 INT304293 Positive_regulation of Negative_regulation of DCPS 2 0.08 3.17 0.64 78.64
48 INT22301 Positive_regulation of Gene_expression of CSF2 66 0.63 59.49 14.24 78.08
49 INT48853 Positive_regulation of BDNF 82 0.69 43.92 27.99 75.00
50 INT23435 Positive_regulation of NGF 54 0.70 32.41 30.11 75.00
51 INT88006 Positive_regulation of GDNF 5 0.45 2.55 2.14 75.00
52 INT164400 Positive_regulation of CNTF 3 0.49 1.66 0.96 75.00
53 INT72924 Negative_regulation of MCRS1 27 0.19 33.59 10.29 73.12
54 INT72923 Positive_regulation of MCRS1 72 0.50 99.19 30.36 70.56
55 INT159631 Positive_regulation of DCPS 60 0.27 43.23 10.3 67.08
56 INT1127 Negative_regulation of IGHG3 32 0.28 21.1 7.37 65.28
57 INT39469 Negative_regulation of Alb 21 0.41 13.33 2.68 64.96
58 INT335980 Regulation of Igfals 1 0.17 2.26 0.12 53.52
59 INT58192 Positive_regulation of MRI1 86 0.61 53.81 24.68 51.80
60 INT75999 Gene_expression of BDNF 344 0.78 114.19 83.12 50.00
61 INT62374 Gene_expression of NGF 158 0.78 77.87 76.45 50.00
62 INT100655 Regulation of BDNF 51 0.60 21.49 13.14 50.00
63 INT85048 Regulation of NGF 19 0.62 11.61 10.5 50.00
64 INT103474 Regulation of Gene_expression of BDNF 40 0.60 12.14 9.65 50.00
65 INT21952 Gene_expression of GDNF 42 0.78 20.32 9.62 50.00
66 INT63374 Regulation of Gene_expression of NGF 12 0.45 5.6 6.4 50.00
67 INT164399 Gene_expression of CNTF 5 0.65 1.73 0.33 50.00
68 INT88007 Regulation of GDNF 2 0.34 0.82 0.16 50.00
69 INT164401 Regulation of Gene_expression of CNTF 1 0.52 0.47 0 50.00
70 INT164398 Regulation of CNTF 1 0.26 0.77 0 50.00
71 INT77415 Localization of GLP1R 23 0.63 11.1 1.69 46.88
72 INT17625 Localization of GCG 210 0.80 55.69 24.97 46.32
73 INT102658 Negative_regulation of Gene_expression of CSF2 42 0.50 38.63 8.32 46.16
74 INT14690 Localization of CSF2 124 0.80 85.17 27.26 39.52
75 INT48390 Negative_regulation of Localization of CSF2 10 0.51 7.39 3.28 39.52
76 INT102843 Negative_regulation of PDC 5 0.57 4.26 1.82 39.04
77 INT355992 Negative_regulation of Negative_regulation of PDC 1 0.21 1.62 0.32 39.04
78 INT16396 Negative_regulation of CEBPZ 76 0.48 30.03 21.6 34.32
79 INT80806 Gene_expression of PDC 12 0.75 4.34 5.73 29.16
80 INT80808 Positive_regulation of Gene_expression of PDC 5 0.53 3.13 3.96 29.16
81 INT155010 Positive_regulation of Gene_expression of IL17A 23 0.64 20.17 7.15 28.04
82 INT145266 Gene_expression of IL17A 154 0.75 109.83 45.33 26.24
83 INT222142 Binding of AMT 5 0.20 0.36 0.03 22.68
84 INT315626 Localization of DLEU1 2 0.35 4.17 0.07 12.40
85 INT191343 Gene_expression of IDO1 23 0.55 11.3 4.81 9.84
86 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
87 INT5842 Gene_expression of Gfap 372 0.78 153.71 127.71 5.00
88 INT170025 Gene_expression of Fig4 588 0.67 183.27 113.32 5.00
89 INT171145 Positive_regulation of Fig4 274 0.59 93.55 69.81 5.00
90 INT6864 Positive_regulation of Gene_expression of Gfap 110 0.70 59.01 47.07 5.00
91 INT170646 Negative_regulation of Fig4 213 0.37 81.29 46.92 5.00
92 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 5.00
93 INT4004 Gene_expression of IGHG3 321 0.71 221.03 42.33 5.00
94 INT61619 Gene_expression of IL12A 194 0.77 146.07 41.97 5.00
95 INT65889 Gene_expression of RETNLB 73 0.34 60.98 38.3 5.00
96 INT6105 Positive_regulation of IL2 133 0.69 82.76 34.67 5.00
97 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 5.00
98 INT22045 Gene_expression of IRF6 158 0.75 58.07 27.81 5.00
99 INT171820 Localization of Fig4 144 0.65 27.38 20.88 5.00
100 INT48663 Negative_regulation of Gene_expression of Gfap 45 0.59 18.34 19.84 5.00
101 INT23533 Gene_expression of CA2 110 0.75 30.81 19.4 5.00
102 INT3060 Negative_regulation of Bche 94 0.59 46.75 18.51 5.00
103 INT170033 Positive_regulation of Gene_expression of Fig4 59 0.43 20.99 16.69 5.00
104 INT1125 Positive_regulation of IGHG3 130 0.69 112.07 13.18 5.00
105 INT61624 Positive_regulation of Gene_expression of IL12A 50 0.56 33.07 13.07 5.00
106 INT148207 Gene_expression of CTLA4 53 0.77 29.13 12.07 5.00
107 INT23676 Gene_expression of Chrna7 47 0.75 23.66 9.51 5.00
108 INT41569 Regulation of APP 32 0.62 17.15 9.4 5.00
109 INT182137 Gene_expression of TLR9 137 0.78 48.48 9.05 5.00
110 INT108931 Negative_regulation of BDNF 38 0.59 19.61 8.84 5.00
111 INT140411 Gene_expression of Nqo1 45 0.60 62.35 8.7 5.00
112 INT72166 Positive_regulation of Gene_expression of RETNLB 14 0.24 10.23 7.27 5.00
113 INT6861 Negative_regulation of Gfap 32 0.58 13.71 7.22 5.00
114 INT55957 Positive_regulation of PRNP 57 0.67 37.87 7.11 5.00
115 INT11957 Negative_regulation of LPA 52 0.59 39.09 6.84 5.00
116 INT159632 Localization of DCPS 24 0.21 18.24 6.8 5.00
117 INT6891 Binding of TTR 72 0.48 22.81 6.51 5.00
118 INT17086 Binding of HSD11B1 84 0.47 122.28 6.16 5.00
119 INT17913 Regulation of HSD11B1 87 0.60 93.23 6.04 5.00
120 INT93684 Gene_expression of STAT3 66 0.78 34.42 5.94 5.00
121 INT38671 Positive_regulation of KRT20 62 0.53 40.17 5.6 5.00
122 INT87420 Gene_expression of BCL2L1 56 0.75 48.84 5.32 5.00
123 INT75682 Regulation of Chrna7 14 0.45 10.24 5.25 5.00
124 INT43707 Positive_regulation of CCBE1 11 0.07 8.22 4.86 5.00
125 INT5838 Negative_regulation of Positive_regulation of Gfap 10 0.58 6.52 4.39 5.00
126 INT9098 Positive_regulation of DBP 30 0.69 15.77 4.26 5.00
127 INT5219 Negative_regulation of DBP 43 0.57 23.35 4.26 5.00
128 INT84703 Negative_regulation of Nqo1 8 0.38 7.1 4.05 5.00
129 INT204529 Positive_regulation of TLR9 18 0.62 15.62 3.99 5.00
130 INT93120 Localization of Gfap 21 0.78 8.42 3.7 5.00
131 INT52047 Gene_expression of APOE 50 0.78 34.75 3.52 5.00
132 INT79270 Gene_expression of MKI67 113 0.77 63.52 3.38 5.00
133 INT110245 Gene_expression of SNCA 11 0.77 8.29 3.36 5.00
134 INT66191 Gene_expression of DBP 42 0.66 22.25 3.18 5.00
135 INT191125 Gene_expression of Igfals 12 0.25 12.96 2.89 5.00
136 INT204524 Binding of TLR9 17 0.43 11.69 2.76 5.00
137 INT33219 Positive_regulation of C5AR1 14 0.67 7.75 2.74 5.00
138 INT21712 Positive_regulation of APOA1 32 0.67 21.64 2.64 5.00
139 INT169987 Transcription of GOPC 45 0.60 21.88 2.61 5.00
140 INT219180 Gene_expression of TLR7 13 0.68 9.51 2.21 5.00
141 INT7206 Binding of HBG1 14 0.47 3.44 2.14 5.00
142 INT161382 Localization of KRT20 25 0.61 12.97 2.13 5.00
143 INT56342 Gene_expression of TTR 34 0.78 16.5 2.05 5.00
144 INT101243 Regulation of STAT3 12 0.62 9.98 1.92 5.00
145 INT258135 Gene_expression of CARTPT 3 0.40 5.25 1.88 5.00
146 INT198568 Regulation of DCPS 17 0.34 16.26 1.86 5.00
147 INT37758 Gene_expression of GC 10 0.75 7.09 1.75 5.00
148 INT47714 Regulation of Nqo1 12 0.24 11.12 1.71 5.00
149 INT163613 Transcription of CSF2 16 0.60 12.98 1.62 5.00
150 INT96814 Negative_regulation of APOE 13 0.59 10.64 1.61 5.00
151 INT202935 Gene_expression of SERPINF1 12 0.50 7.53 1.54 5.00
152 INT87361 Negative_regulation of TTR 25 0.57 5.74 1.51 5.00
153 INT204530 Positive_regulation of Gene_expression of TLR9 14 0.70 6.85 1.48 5.00
154 INT151540 Regulation of Fmr1 8 0.59 6.08 1.34 5.00
155 INT61999 Gene_expression of MAPT 19 0.75 15.4 1.3 5.00
156 INT18478 Protein_catabolism of CSF2 6 0.88 1.75 1.26 5.00
157 INT16013 Gene_expression of Rac1 52 0.75 23.79 1.21 5.00
158 INT110244 Positive_regulation of Gene_expression of SNCA 5 0.69 4.66 1.19 5.00
159 INT280858 Localization of IFNAR1 5 0.39 4.5 1.09 5.00
160 INT92288 Binding of Igfals 3 0.13 3.14 1 5.00
161 INT70323 Negative_regulation of Gene_expression of CA2 13 0.41 6.55 0.97 5.00
162 INT143006 Gene_expression of A1BG 23 0.73 22.92 0.88 5.00
163 INT24142 Regulation of DLEU1 1 0.21 1.01 0.85 5.00
164 INT355989 Positive_regulation of Localization of DCPS 1 0.05 1.83 0.8 5.00
165 INT294787 Localization of TLR9 2 0.67 2.35 0.75 5.00
166 INT246552 Transcription of Fmr1 11 0.72 6.72 0.71 5.00
167 INT355991 Positive_regulation of Localization of IFNAR1 1 0.14 2.01 0.69 5.00
168 INT191123 Positive_regulation of Igfals 3 0.18 2.89 0.68 5.00
169 INT293249 Localization of IDO1 3 0.38 0.77 0.68 5.00
170 INT174806 Localization of CAPG 3 0.41 2.54 0.65 5.00
171 INT44478 Negative_regulation of PTEN 32 0.57 27.45 0.63 5.00
172 INT236837 Regulation of Negative_regulation of CSF2 2 0.32 1.83 0.61 5.00
173 INT14318 Negative_regulation of MAPT 3 0.57 2.05 0.59 5.00
174 INT118716 Positive_regulation of MAPT 4 0.49 7.25 0.54 5.00
175 INT293250 Positive_regulation of Localization of IDO1 2 0.24 0.78 0.54 5.00
176 INT334212 Negative_regulation of DLEU1 2 0.28 8.84 0.53 5.00
177 INT148884 Negative_regulation of HCRTR1 7 0.23 7.23 0.53 5.00
178 INT124250 Binding of APOA4 3 0.18 4.83 0.53 5.00
179 INT20239 Regulation of APOA1 10 0.60 10.98 0.51 5.00
180 INT245223 Negative_regulation of Gene_expression of TLR7 3 0.37 2.81 0.5 5.00
181 INT340755 Negative_regulation of CARTPT 2 0.30 2.08 0.4 5.00
182 INT208553 Phosphorylation of YWHAQ 4 0.80 3.42 0.36 5.00
183 INT188755 Positive_regulation of Binding of CSF2 6 0.44 8.79 0.35 5.00
184 INT279985 Transcription of BCL2L1 5 0.69 3.76 0.34 5.00
185 INT131542 Negative_regulation of Gene_expression of APOE 6 0.40 3.92 0.33 5.00
186 INT189968 Binding of APOA1 12 0.47 10.1 0.3 5.00
187 INT137453 Gene_expression of APOA4 2 0.17 1.21 0.26 5.00
188 INT124944 Regulation of KIT 15 0.60 11.84 0.24 5.00
189 INT213243 Negative_regulation of Gene_expression of DBP 7 0.42 2.68 0.2 5.00
190 INT115701 Negative_regulation of Gene_expression of TTR 4 0.43 1.04 0.2 5.00
191 INT173956 Negative_regulation of Gene_expression of CTLA4 3 0.37 0.91 0.2 5.00
192 INT279977 Transcription of FGG 1 0.47 1.3 0.2 5.00
193 INT248772 Negative_regulation of Binding of CSF2 4 0.39 5.16 0.19 5.00
194 INT279976 Regulation of APOA4 1 0.12 1.23 0.18 5.00
195 INT279982 Localization of APOA4 1 0.17 1.21 0.18 5.00
196 INT70447 Gene_expression of FRA9C 2 0.01 0.5 0.17 5.00
197 INT101450 Positive_regulation of DLEU1 2 0.22 2.65 0.12 5.00
198 INT179115 Negative_regulation of Localization of Fig4 5 0.33 1.94 0.11 5.00
199 INT279978 Regulation of SERPINF1 1 0.19 1.13 0.08 5.00
200 INT306561 Positive_regulation of OR4F8P 1 0.01 0.06 0.06 5.00
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