D:Obesity

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pChart

Disease Term
Synonyms Adipocytes, ADIPOSE TISSUE, BODY MASS INDEX, Diabetes Mellitus Type Ii Obesity, FAT CELL, Fat Cells, INCREASED APPETITE, NOCICEPTIVE PAIN OBESITY, Ob Gene, OB KNOCK OUT, Ob Mice
Documents 9504
Hot Single Events 200
Hot Interactions 200

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Obesity. They are ordered first by their relevance to Obesity and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT323880 Binding of BMI1 and LEP 1 0.02 3.97 0.41 100.00
2 INT240619 Binding of CRP and ADIPOQ 8 0.18 10.74 0.78 100.00
3 INT296960 Binding of NRIP1 and MLST8 1 0.03 2.65 0 100.00
4 INT305271 Binding of Lep and Obsty1 1 0.06 4.86 0 100.00
5 INT323883 BMI1 Regulation of LEP 1 0.02 2.39 0.23 100.00
6 INT183781 Binding of IL6 and INS 6 0.22 8.97 1.87 100.00
7 INT306794 Binding of LEP and COPD 1 0.15 3.94 0.09 100.00
8 INT305257 Obsty1 Regulation of Gene_expression of Mapk1 1 0.03 2.05 0.08 100.00
9 INT309889 Positive_regulation of CNR1 Positive_regulation of LPL 1 0.05 1.25 0 100.00
10 INT207184 Binding of Adipoq and Lep 1 0.25 2.45 0.33 100.00
11 INT305255 Obsty1 Positive_regulation of Phosphorylation of Akt1 1 0.05 2.09 0 100.00
12 INT325284 Binding of COMP and MCL1 1 0.01 1.69 0 100.00
13 INT349083 Binding of Lep and Rtn1 1 0.09 1.68 0.57 100.00
14 INT227303 Zbp1 Regulation of Transcription of Baat 1 0.09 1.43 0.08 100.00
15 INT323882 Binding of BMI1 and MMP13 1 0.01 1.26 0.11 100.00
16 INT296955 Binding of CIDEA and MLST8 1 0.02 0.97 0 100.00
17 INT305253 Obsty1 Negative_regulation of Phosphorylation of Akt1 1 0.04 2.36 0 100.00
18 INT208910 Ubl4 Regulation of Regulation of FDX1 1 0.01 0.85 0.45 100.00
19 INT323869 Binding of BMI1 and COL1A2 1 0.00 1.21 0.11 100.00
20 INT323875 Binding of BMI1 and IGF1 1 0.01 1.2 0.11 100.00
21 INT305281 Obsty1 Regulation of Localization of Gopc 1 0.02 1.49 0 100.00
22 INT323886 BMI1 Regulation of Gene_expression of MMP13 1 0.01 1.13 0.12 100.00
23 INT352518 Binding of FAT1 and Adipoq 1 0.01 2.79 0.2 100.00
24 INT104327 Fen1 Negative_regulation of Baat 1 0.31 0.75 0.12 100.00
25 INT104325 Regulation of Fen1 Negative_regulation of Baat 1 0.19 0.75 0.12 100.00
26 INT81179 LEP Regulation of Localization of GH1 1 0.11 0.91 0.12 100.00
27 INT345966 Binding of Arid1a and al44 1 0.00 1.56 0.05 100.00
28 INT296958 NRIP1 Regulation of Gene_expression of MLST8 1 0.04 0.76 0 100.00
29 INT323881 BMI1 Regulation of Gene_expression of LEP 1 0.03 1.09 0.08 100.00
30 INT305259 Binding of Car2 and Obsty1 1 0.02 1.2 0 100.00
31 INT305266 Obsty1 Negative_regulation of Phosphorylation of Mapk14 1 0.03 1.05 0 100.00
32 INT104326 Regulation of Fen1 Positive_regulation of Baat 1 0.19 0.63 0 100.00
33 INT104328 Fen1 Positive_regulation of Baat 1 0.33 0.63 0 100.00
34 INT305276 Obsty1 Regulation of Phosphorylation of Mapk1 1 0.02 1.11 0 100.00
35 INT305278 Lep Negative_regulation of Obsty1 1 0.07 0.94 0 100.00
36 INT249760 Positive_regulation of Cnr1 Negative_regulation of Gene_expression of Adipoq 1 0.20 0.81 0.22 100.00
37 INT325283 Negative_regulation of MCL1 Positive_regulation of Gene_expression of ADIPOQ 1 0.14 1.53 0 100.00
38 INT305254 Obsty1 Regulation of Gene_expression of Nos3 1 0.03 0.97 0 100.00
39 INT305262 Obsty1 Positive_regulation of Phosphorylation of Nos3 1 0.05 0.96 0 100.00
40 INT305274 Obsty1 Regulation of Gene_expression of Prkag1 1 0.01 0.94 0.08 100.00
41 INT305277 Positive_regulation of Binding of Lep and Obsty1 1 0.08 0.93 0 100.00
42 INT207186 Binding of Adipoq and Bmi1 1 0.01 1.65 0.18 100.00
43 INT305280 Lep Positive_regulation of Gene_expression of Leprot 1 0.07 1.03 0 100.00
44 INT305269 Lep Positive_regulation of Phosphorylation of Stat3 1 0.40 1.03 0 100.00
45 INT305268 Obsty1 Positive_regulation of Lipo2 1 0.00 0.93 0 100.00
46 INT207185 Binding of Bmi1 and Lep 1 0.01 1.7 0.21 100.00
47 INT305263 Obsty1 Regulation of Phosphorylation of Prkag1 1 0.01 0.78 0 100.00
48 INT305267 Lep Regulation of Obsty1 1 0.04 0.97 0 100.00
49 INT305260 Obsty1 Regulation of Prkag1 1 0.01 0.78 0 100.00
50 INT249759 Positive_regulation of Cnr1 Positive_regulation of Lpl 1 0.29 0.74 0.21 100.00
51 INT291173 Ins1 Regulation of Baat 1 0.12 0.83 0 100.00
52 INT236147 Binding of Ins1 and Ptpn1 2 0.03 1.29 0.05 100.00
53 INT282420 Spp1 Positive_regulation of Ins1 1 0.20 1.25 0.32 100.00
54 INT295478 IRF6 Positive_regulation of Positive_regulation of TLR4 2 0.20 0.78 0.39 100.00
55 INT350016 Binding of CD40LG and ARID1B 1 0.01 3.26 0.21 100.00
56 INT305252 Obsty1 Positive_regulation of Mapk8 1 0.05 1.52 0 100.00
57 INT291174 Rpa1 Positive_regulation of Baat 1 0.03 0.63 0.04 100.00
58 INT305265 Obsty1 Negative_regulation of Phosphorylation of Nos3 1 0.05 0.78 0 100.00
59 INT352500 Binding of FAT1 and INS 1 0.01 1.38 0.1 100.00
60 INT306795 Binding of LEP and SFTPD 1 0.08 1.13 0.23 100.00
61 INT262994 Binding of CRP and HSD11B1 1 0.15 3.02 0.03 100.00
62 INT228174 RNU1-1 Positive_regulation of Gene_expression of Adipoq 1 0.12 0.55 0.08 100.00
63 INT73794 Binding of HSD11B1 and Igfbp1 1 0.06 1.15 0.07 100.00
64 INT210862 Binding of POMC and Mc4r 1 0.34 0.42 0.17 100.00
65 INT206059 IL6 Positive_regulation of INS 1 0.02 1.16 0.16 100.00
66 INT228175 RNU1-1 Regulation of Adipoq 1 0.11 0.78 0.12 100.00
67 INT105873 Ins1 Negative_regulation of Positive_regulation of Lep 1 0.27 0.67 0.31 100.00
68 INT105874 Lep Negative_regulation of Positive_regulation of Ins1 1 0.27 0.67 0.31 100.00
69 INT323884 BMI1 Regulation of Gene_expression of TIMP2 1 0.01 0.64 0.21 100.00
70 INT181835 Binding of Baat and Ppara 1 0.09 0.31 0 100.00
71 INT307774 Binding of ARMC9 and RCT 1 0.01 1.27 0 100.00
72 INT65644 Binding of AFA and Dbp 1 0.10 0.86 0.1 100.00
73 INT262997 Binding of HSD11B1 and ADIPOQ 1 0.54 2.82 0.07 100.00
74 INT137368 Retn Positive_regulation of Gene_expression of IGF1 1 0.00 0.17 0.1 100.00
75 INT296945 ADIPOQ Negative_regulation of TNF 1 0.03 1.13 0.4 100.00
76 INT274531 Il6 Regulation of Localization of Lpl 1 0.04 1.49 0.33 100.00
77 INT274530 Il6 Regulation of Lpl 1 0.07 1.48 0.32 100.00
78 INT170560 Binding of Renbp and Narf 1 0.01 1.69 0.27 100.00
79 INT145886 Binding of CXCL1 and Adipoq 1 0.00 0.77 0.2 100.00
80 INT327821 GPRC6A Regulation of Gene_expression of Lep 1 0.00 0.5 0.05 100.00
81 INT327822 INCENP Regulation of Gene_expression of Lep 1 0.00 0.5 0.05 100.00
82 INT292816 Binding of KCNJ11 and FTO 1 0.46 0.49 0.05 100.00
83 INT292815 Binding of CDC123 and FTO 1 0.50 0.48 0.05 100.00
84 INT278251 Binding of PCOS1 and Hypism 1 0.00 1.22 0.04 100.00
85 INT278250 Binding of PCOS1 and Ins1 1 0.00 1.23 0.04 100.00
86 INT253368 Positive_regulation of Lep Positive_regulation of Prkaa2 1 0.26 0.19 0 100.00
87 INT210827 Binding of EPB41 and TPM3 1 0.03 0.17 0.06 99.98
88 INT289525 Sirt1 Negative_regulation of Negative_regulation of Ucp2 1 0.32 0.86 0.15 99.96
89 INT239355 Binding of Nr1h2 and Positive_regulation of Gene_expression of CETP 1 0.17 3.75 0.14 99.96
90 INT19495 Pomc Negative_regulation of Ins1 1 0.25 0.27 0 99.96
91 INT289536 Sirt1 Negative_regulation of Localization of Pparg 1 0.13 0.43 0.08 99.96
92 INT289603 Sirt1 Negative_regulation of Localization of PPARG 1 0.02 0.43 0.08 99.96
93 INT289540 Sirt1 Negative_regulation of Localization of Ins1 1 0.03 0.43 0.08 99.96
94 INT289533 Sirt1 Negative_regulation of Pparg 1 0.18 0.42 0.07 99.96
95 INT289602 Sirt1 Negative_regulation of PPARG 1 0.02 0.37 0.07 99.96
96 INT305264 Positive_regulation of Binding of Lep and Leprot 1 0.08 0.93 0 99.92
97 INT305273 Binding of Lep and Leprot 1 0.06 0.92 0 99.92
98 INT293627 GHRL Positive_regulation of EDNRA 1 0.00 0.96 0.1 99.92
99 INT251115 Positive_regulation of Binding of AR and Ctnnb1 1 0.01 1.02 0.13 99.92
100 INT335053 PPARA Positive_regulation of Gene_expression of LPL 1 0.21 0.34 0.19 99.92
101 INT350835 Binding of SELS and Sels 1 0.16 1.24 0.26 99.90
102 INT231605 Binding of PSMD1 and SGCG 1 0.02 0.34 0.04 99.90
103 INT326067 APOA1 Positive_regulation of Localization of APOE 1 0.61 4.22 0.07 99.88
104 INT326059 APOA1 Positive_regulation of Gene_expression of APOE 1 0.61 0.38 0 99.88
105 INT253377 Lep Negative_regulation of Phosphorylation of Prkaa2 1 0.24 1.24 0.06 99.86
106 INT332960 Atp6v1e1 Negative_regulation of Ppara 1 0.18 0.99 0 99.86
107 INT278184 Binding of Crp and Hdlcl1 1 0.01 2.72 0.09 99.84
108 INT237325 Il6 Positive_regulation of Gene_expression of Ik 2 0.00 2.09 0.72 99.84
109 INT51876 CCBE1 Regulation of GHRH 1 0.01 1.07 0 99.84
110 INT278183 Binding of Crp and Ggt1 1 0.01 1.09 0.04 99.84
111 INT276213 Pten Regulation of Phosphorylation of Akt1 1 0.51 0.61 0.72 99.84
112 INT268326 Ins1 Regulation of Gene_expression of VEGFA 1 0.01 0.32 0.05 99.84
113 INT67553 Ghrh Positive_regulation of Regulation of Gh 1 0.04 0.55 0.39 99.84
114 INT328309 GHS Positive_regulation of Localization of GH1 1 0.04 0.99 0.12 99.84
115 INT238819 Binding of LTF and RBP4 1 0.04 0.26 0 99.84
116 INT9180 Ghrh Regulation of Localization of Gh 3 0.24 0.25 2.18 99.84
117 INT230423 INS Negative_regulation of Lipg 1 0.03 0.74 0.03 99.84
118 INT265950 Clas4 Negative_regulation of Gene_expression of AGT 1 0.02 0.62 0 99.84
119 INT173130 Binding of INS and PPARA 2 0.04 1.8 0.08 99.82
120 INT97795 IRF6 Positive_regulation of Localization of TNF 3 0.09 1.57 0.86 99.80
121 INT187667 DBT Positive_regulation of Localization of LEP 1 0.05 0.55 0 99.80
122 INT142932 Binding of Arid1a and Samsn1 1 0.01 1.55 0 99.80
123 INT26468 Ghrh Positive_regulation of Localization of Gh 21 0.37 3.26 9.21 99.78
124 INT323870 LEP Regulation of Gene_expression of MMP13 1 0.21 1.76 0.33 99.78
125 INT323873 LEP Regulation of Gene_expression of TIMP2 1 0.31 0.63 0.21 99.78
126 INT223318 Binding of ESR1 and ESR2 1 0.40 1.22 0 99.76
127 INT278295 DBP Positive_regulation of SHBG 1 0.02 0.92 0 99.76
128 INT238825 LTF Regulation of Localization of RBP4 1 0.05 1.08 0.16 99.76
129 INT291467 Binding of Hcrt and Hcrtr1 1 0.53 0.87 0.07 99.76
130 INT260727 Binding of Gfm1 and NAFLD2 1 0.00 1.05 0 99.76
131 INT260726 Positive_regulation of Binding of Gfm1 and NAFLD2 1 0.00 1.05 0 99.76
132 INT240131 Binding of Crp and Nppb 7 0.07 11.53 2.12 99.72
133 INT209854 IL4 Positive_regulation of Gene_expression of CD36 1 0.51 1.2 0.65 99.72
134 INT302379 Crp Positive_regulation of Gene_expression of Ccl2 1 0.10 4.58 0.84 99.72
135 INT67243 Ncoa6 Positive_regulation of Localization of Ins1 1 0.22 0.1 0.08 99.72
136 INT69566 Positive_regulation of Ghrh Regulation of Gh 1 0.04 1.66 0.55 99.70
137 INT309888 INS Positive_regulation of Gene_expression of FAAH 1 0.04 1.19 0.25 99.70
138 INT269180 LEP Positive_regulation of Localization of TNF 1 0.01 0.99 0.21 99.70
139 INT227304 Zbp1 Regulation of Transcription of Ucp2 1 0.17 1.43 0.08 99.68
140 INT314370 Adipoq Positive_regulation of Tnfrsf11a 1 0.04 1.26 0.03 99.68
141 INT69872 Binding of MC1R and POMC 52 0.54 8.87 18.3 99.64
142 INT146611 Ins1 Positive_regulation of Phosphorylation of Akt1 9 0.23 4.34 0.37 99.64
143 INT213160 AGT Positive_regulation of Gene_expression of LEP 1 0.08 1.29 0.03 99.60
144 INT296956 NRIP1 Regulation of Gene_expression of CIDEA 1 0.44 0.76 0 99.60
145 INT295472 IRF6 Positive_regulation of Gene_expression of TNF 2 0.16 0.95 0.27 99.60
146 INT155530 IRF6 Regulation of Gene_expression of IL8 1 0.06 0.79 0.26 99.56
147 INT155529 IRF6 Regulation of Transcription of IL6 1 0.08 0.79 0.26 99.56
148 INT345965 Binding of Lep and al44 1 0.01 1.43 0.05 99.56
149 INT291257 Map3k8 Regulation of Positive_regulation of MAPK1 1 0.09 1 0.28 99.54
150 INT291239 Map3k8 Regulation of Positive_regulation of Mdk 1 0.08 0.53 0.11 99.54
151 INT296954 NRIP1 Negative_regulation of Gene_expression of UCP1 1 0.30 1.05 0 99.52
152 INT323503 STARD7 Positive_regulation of Ghrl 1 0.24 1.92 0.05 99.52
153 INT16221 Ghrh Positive_regulation of Gh 8 0.21 1.89 4.08 99.52
154 INT319119 SERPINE1 Negative_regulation of Positive_regulation of PLG 1 0.11 1.56 0.15 99.52
155 INT239323 Binding of Nr1h2 and Positive_regulation of Positive_regulation of Tgfb1 1 0.00 3.71 0.14 99.52
156 INT253155 TNF Positive_regulation of Positive_regulation of Mapk8 1 0.19 0.62 0.31 99.52
157 INT253153 TNF Positive_regulation of Mapk8 1 0.18 0.61 0.31 99.52
158 INT339044 Binding of PITX2 and SUGT1 1 0.00 2.25 0 99.48
159 INT51877 CCBE1 Regulation of NPY 1 0.01 1.06 0 99.48
160 INT314133 Lep Positive_regulation of Gene_expression of Ppargc1a 1 0.51 0.79 0 99.48
161 INT295474 IRF6 Positive_regulation of MAP2K1 1 0.18 0.41 0.03 99.48
162 INT128986 Binding of CST3 and Phdlc1 1 0.01 1.96 0.22 99.48
163 INT298781 Positive_regulation of PPARA Positive_regulation of TUSC5 1 0.37 0.15 0.09 99.48
164 INT239605 Ghrh Negative_regulation of Gh 1 0.01 0.53 0.04 99.46
165 INT254496 Binding of HNF4A and GOPC 1 0.10 0.34 0.08 99.44
166 INT254498 Binding of SREBF1 and GOPC 1 0.05 0.34 0.08 99.44
167 INT254495 Binding of PPARA and GOPC 1 0.04 0.34 0.08 99.44
168 INT290026 Binding of PPARG and CHDH 1 0.10 6.61 0 99.42
169 INT107747 CRH Negative_regulation of HSD17B1 1 0.40 0.41 0.3 99.42
170 INT107751 POMC Negative_regulation of HSD17B1 1 0.33 0.39 0.33 99.42
171 INT217661 LEP Positive_regulation of INS 2 0.25 1.85 0.19 99.40
172 INT323487 Ghrl Positive_regulation of Phosphorylation of Akt1 1 0.09 0.77 0 99.40
173 INT249831 Binding of CHI3L1 and IL6 1 0.30 2.81 0.26 99.36
174 INT214138 Son Regulation of Gene_expression of Pomc 1 0.05 0.1 0.09 99.36
175 INT214161 Pomc Regulation of Mc4r 1 0.21 0.1 0.09 99.36
176 INT10844 Ghrh Regulation of Gh 13 0.13 4.77 4.71 99.34
177 INT253128 Il6 Positive_regulation of Gene_expression of Ins1 1 0.14 3.2 0.19 99.32
178 INT227301 Zbp1 Regulation of Transcription of Ucp1 1 0.19 1.42 0.08 99.32
179 INT120851 NFKB1 Positive_regulation of Localization of TNF 3 0.04 2.05 0.62 99.32
180 INT295480 MAPK14 Positive_regulation of Localization of TNF 1 0.08 1.08 0.12 99.32
181 INT326057 APOA1 Regulation of Localization of APOE 1 0.54 1.36 0 99.32
182 INT342170 Insr Regulation of Localization of Cd320 1 0.08 0.92 0.04 99.32
183 INT301623 Ins1 Positive_regulation of Slc27a2 1 0.01 0.37 0.07 99.30
184 INT51878 CCBE1 Regulation of CRH 1 0.01 1.06 0 99.28
185 INT251114 Binding of AR and Ctnnb1 1 0.01 1 0.12 99.26
186 INT350824 INS Positive_regulation of Gene_expression of SELS 1 0.22 0.85 0 99.24
187 INT207845 Binding of INS and Hypism 3 0.04 2.88 0.22 99.24
188 INT254759 Igh-Dex Positive_regulation of Localization of Apoe 1 0.00 0.32 0.28 99.24
189 INT279901 Binding of FADS3 and USF1 1 0.35 4.71 0 99.24
190 INT323572 Negative_regulation of Lipe Positive_regulation of Positive_regulation of Ly6 1 0.00 0.1 0 99.24
191 INT298783 PPARA Positive_regulation of TUSC5 1 0.37 0.15 0.09 99.22
192 INT325285 COMP Positive_regulation of UBR5 1 0.00 2.9 0 99.20
193 INT242974 Mapk8 Negative_regulation of Positive_regulation of Esr1 1 0.01 1.39 0.05 99.20
194 INT202231 Binding of IGF1 and INS 2 0.28 1.38 0.03 99.18
195 INT204087 IL1B Positive_regulation of Gene_expression of LEP 1 0.09 2.6 0.54 99.16
196 INT207554 GH1 Negative_regulation of Phosphorylation of INS 1 0.26 0.28 0.03 99.16
197 INT207555 GH1 Negative_regulation of Phosphorylation of IRS1 1 0.10 0.28 0.03 99.16
198 INT207553 GH1 Negative_regulation of INS 1 0.27 0.28 0.03 99.16
199 INT204086 TNF Positive_regulation of Gene_expression of LEP 1 0.48 0.74 0.1 99.16
200 INT240625 Binding of CRP and Hdlcl1 1 0.01 2.56 0.19 99.12

Single Events

The table below shows the top 200 pain related interactions that have been reported for Obesity. They are ordered first by their pain relevance and then by number of times they were reported in Obesity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 100.00
2 INT17881 Gene_expression of LEP 278 0.78 221.61 48.31 100.00
3 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 100.00
4 INT109411 Gene_expression of SAT1 61 0.77 67.99 3.08 100.00
5 INT26975 Gene_expression of Adipoq 113 0.75 106.71 14.46 100.00
6 INT86024 Gene_expression of PPARA 736 0.78 497.93 91.14 100.00
7 INT101483 Gene_expression of Lep 159 0.78 104.77 25.12 100.00
8 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 100.00
9 INT1893 Localization of Gh 1041 0.79 340.23 256.58 100.00
10 INT8747 Positive_regulation of Ins1 221 0.69 154.28 35.15 100.00
11 INT82434 Positive_regulation of LEP 117 0.70 95.45 20.22 100.00
12 INT6852 Localization of TNF 883 0.81 705.95 270.84 100.00
13 INT298821 Gene_expression of TUSC5 1 0.77 32.53 2.76 100.00
14 INT166021 Positive_regulation of MCL1 36 0.67 62.97 1.44 100.00
15 INT115386 Gene_expression of Ppara 779 0.77 549.99 128.36 100.00
16 INT217691 Gene_expression of LIPE 24 0.70 29.84 1.87 100.00
17 INT66332 Gene_expression of Ucp1 40 0.75 40.09 2.48 100.00
18 INT250581 Gene_expression of SELS 4 0.78 47.37 3.27 100.00
19 INT76123 Gene_expression of Lep 193 0.78 94.17 22.76 100.00
20 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 100.00
21 INT62681 Negative_regulation of LEP 93 0.59 66.97 15.77 100.00
22 INT3657 Gene_expression of Ins1 514 0.78 321.69 75.76 100.00
23 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 100.00
24 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 100.00
25 INT91544 Gene_expression of CHI3L1 60 0.75 77.72 13.9 100.00
26 INT84546 Positive_regulation of Ppara 481 0.70 334.21 83.45 100.00
27 INT164587 Gene_expression of MCL1 94 0.75 124.05 5.39 100.00
28 INT101481 Positive_regulation of Lep 81 0.69 62.59 9.95 100.00
29 INT8210 Positive_regulation of Gene_expression of INS 188 0.68 146.57 12.83 100.00
30 INT11361 Gene_expression of SERPINE1 183 0.78 136.45 27.97 100.00
31 INT137454 Gene_expression of ADIPOQ 88 0.78 85.32 6.2 100.00
32 INT296992 Gene_expression of MLST8 19 0.07 18.39 0.73 100.00
33 INT171253 Positive_regulation of BMI1 23 0.53 39.41 11.23 100.00
34 INT75908 Regulation of LEP 77 0.60 60.16 15.19 100.00
35 INT252 Localization of GH1 529 0.80 227.4 122.05 100.00
36 INT296996 Negative_regulation of NRIP1 1 0.59 14.18 0.03 100.00
37 INT126743 Positive_regulation of Gene_expression of LEP 61 0.66 50.02 11.17 100.00
38 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 100.00
39 INT99720 Positive_regulation of SAT1 21 0.69 26.55 1.56 100.00
40 INT100139 Positive_regulation of Gene_expression of PPARA 160 0.63 97.78 14.53 100.00
41 INT110988 Gene_expression of Insr 58 0.42 42.12 12.18 100.00
42 INT18322 Negative_regulation of Ins1 132 0.58 88.49 22.59 100.00
43 INT14572 Binding of INS 205 0.48 175.43 13.38 100.00
44 INT101482 Negative_regulation of Lep 53 0.54 33.59 5.65 100.00
45 INT25152 Gene_expression of SAA1 37 0.75 53.56 8.07 100.00
46 INT65356 Localization of LEP 46 0.79 41.17 5.43 100.00
47 INT146043 Positive_regulation of Gene_expression of Adipoq 39 0.67 29.93 6.12 100.00
48 INT117500 Gene_expression of Adipoq 90 0.74 67.79 16.58 100.00
49 INT103094 Binding of PPARA 308 0.47 177.26 34.75 100.00
50 INT75907 Binding of LEP 53 0.46 46.65 8.44 100.00
51 INT35928 Positive_regulation of Baat 12 0.69 12.23 5.43 100.00
52 INT100861 Binding of CRP 179 0.48 175.2 26.45 100.00
53 INT56310 Gene_expression of Baat 15 0.44 15.5 1.11 100.00
54 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 100.00
55 INT122041 Binding of Ppara 308 0.48 189.17 51.48 100.00
56 INT165228 Binding of BMI1 13 0.47 25.36 7.97 100.00
57 INT83431 Binding of ADIPOQ 35 0.48 33.63 3.83 100.00
58 INT6488 Gene_expression of Tnf 484 0.78 339.61 191.58 100.00
59 INT1472 Positive_regulation of Ins1 349 0.69 146.2 86.36 100.00
60 INT102546 Gene_expression of Ccl2 197 0.78 192.8 67.41 100.00
61 INT227275 Negative_regulation of Gene_expression of Adipoq 19 0.53 19.51 1.15 100.00
62 INT306949 Gene_expression of NAMPT 27 0.67 24.47 2.86 100.00
63 INT171252 Gene_expression of BMI1 21 0.70 26.98 4.11 100.00
64 INT207183 Binding of Bmi1 1 0.01 16.24 1.14 100.00
65 INT163581 Localization of Lep 27 0.79 18.99 4.08 100.00
66 INT91338 Binding of Lep 31 0.48 26.86 5.39 100.00
67 INT12082 Localization of IL6 365 0.81 241.78 105.78 100.00
68 INT16303 Negative_regulation of Localization of GH1 89 0.59 37.31 22.15 100.00
69 INT82082 Localization of Lep 63 0.81 26.41 8.56 100.00
70 INT2774 Binding of Crp 241 0.48 195.89 44.39 100.00
71 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 100.00
72 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 100.00
73 INT102935 Regulation of Lep 31 0.60 18.47 5.24 100.00
74 INT36405 Positive_regulation of Insr 26 0.66 24.5 7.24 100.00
75 INT1026 Binding of Lbp 207 0.48 150.96 119.16 100.00
76 INT207569 Gene_expression of VAT1 4 0.17 9.86 0.53 100.00
77 INT1200 Negative_regulation of Ins1 274 0.58 155.17 56.14 100.00
78 INT121666 Positive_regulation of Gene_expression of Ucp1 14 0.67 11.62 0.75 100.00
79 INT133112 Regulation of Baat 2 0.61 11.99 1.2 100.00
80 INT62630 Positive_regulation of CNR1 86 0.70 40.34 51.51 100.00
81 INT305247 Gene_expression of Obsty1 1 0.11 11.21 0.11 100.00
82 INT195454 Regulation of SAT1 5 0.45 7.65 0.85 100.00
83 INT296997 Positive_regulation of Gene_expression of NRIP1 1 0.70 5.77 0 100.00
84 INT154104 Binding of ARID1B 47 0.39 69.82 1.49 100.00
85 INT1322 Positive_regulation of Localization of INS 293 0.70 120.86 45.98 100.00
86 INT204340 Localization of ADIPOQ 20 0.75 25.18 2.64 100.00
87 INT82078 Negative_regulation of Lep 54 0.59 20.47 9.38 100.00
88 INT4360 Gene_expression of Hypism 29 0.22 38.1 4.07 100.00
89 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 100.00
90 INT85943 Negative_regulation of Nos2 161 0.59 108.56 42.65 100.00
91 INT51392 Negative_regulation of Insr 18 0.27 14.75 4.84 100.00
92 INT296978 Negative_regulation of MLST8 3 0.04 5.26 0.18 100.00
93 INT104324 Negative_regulation of Baat 4 0.38 9.79 0.42 100.00
94 INT4606 Regulation of Gene_expression of INS 67 0.61 54.69 7.53 100.00
95 INT45176 Negative_regulation of LPL 34 0.59 22.22 2.01 100.00
96 INT298807 Positive_regulation of Gene_expression of TUSC5 1 0.69 6.08 0.64 100.00
97 INT248321 Regulation of Gene_expression of CHI3L1 2 0.44 10.73 1.64 100.00
98 INT23257 Regulation of CRP 127 0.62 100.05 21.87 100.00
99 INT61893 Gene_expression of Ghrl 125 0.75 71.49 15.14 100.00
100 INT198052 Positive_regulation of Gene_expression of MCL1 19 0.48 24.19 0.47 100.00
101 INT38265 Gene_expression of LPL 22 0.78 10.59 1.09 100.00
102 INT39468 Positive_regulation of hf 10 0.33 13.5 1.32 100.00
103 INT298822 Positive_regulation of TUSC5 1 0.69 5.45 0.51 100.00
104 INT192762 Localization of SAA1 10 0.78 12.63 1.44 100.00
105 INT114058 Negative_regulation of Gene_expression of Insr 13 0.31 9.23 4.97 100.00
106 INT82077 Positive_regulation of Gene_expression of Lep 32 0.70 17.9 3.5 100.00
107 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18 100.00
108 INT4146 Binding of SHBG 49 0.47 31 4.71 100.00
109 INT45839 Regulation of LPL 10 0.55 7.64 0.55 100.00
110 INT186790 Regulation of NRIP1 4 0.45 6.68 0.64 100.00
111 INT292033 Negative_regulation of Gene_expression of PLIN1 1 0.56 4.11 0.14 100.00
112 INT305242 Binding of Obsty1 1 0.07 9.33 0.17 100.00
113 INT1652 Regulation of Pomc 387 0.62 61.01 186.51 100.00
114 INT112974 Gene_expression of Ucp1 12 0.78 7.72 2.45 100.00
115 INT164582 Negative_regulation of MCL1 56 0.56 67.11 2.82 100.00
116 INT198852 Positive_regulation of Ucp1 8 0.61 8 1.53 100.00
117 INT70970 Binding of COPD 144 0.42 180.34 18.29 100.00
118 INT147792 Gene_expression of COPD 230 0.70 287.13 24.1 100.00
119 INT188241 Negative_regulation of ADIPOQ 16 0.43 22.16 1.47 100.00
120 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 100.00
121 INT207568 Negative_regulation of VAT1 1 0.13 8.92 0.55 100.00
122 INT124736 Positive_regulation of Gene_expression of Insr 6 0.31 7.55 3.12 100.00
123 INT56309 Positive_regulation of Baat 9 0.39 8.47 1.51 100.00
124 INT171251 Regulation of BMI1 8 0.20 10.46 2.01 100.00
125 INT3161 Regulation of Localization of Gh 163 0.61 35.43 59.45 100.00
126 INT92330 Gene_expression of WDTC1 22 0.47 13.12 5.15 100.00
127 INT122037 Regulation of Ppara 93 0.62 56.28 12.89 100.00
128 INT158 Localization of Prl 2431 0.81 378.96 952.2 100.00
129 INT207182 Positive_regulation of Bmi1 1 0.02 6.81 0.41 100.00
130 INT2276 Regulation of Ins1 234 0.61 103.78 54.05 100.00
131 INT125312 Positive_regulation of COPD 134 0.59 162.55 20.27 100.00
132 INT179481 Positive_regulation of Wdtc1 8 0.67 7.11 0.71 100.00
133 INT298808 Negative_regulation of Gene_expression of TUSC5 1 0.43 3.9 0.42 100.00
134 INT11030 Binding of LPA 70 0.48 40.35 4.81 100.00
135 INT82828 Positive_regulation of COMP 45 0.61 35.12 6.2 100.00
136 INT227280 Regulation of Gene_expression of Baat 4 0.26 3.82 0.14 100.00
137 INT159041 Negative_regulation of TUSC5 2 0.42 3.46 0.48 100.00
138 INT181826 Transcription of Baat 4 0.35 4.43 0.2 100.00
139 INT164588 Regulation of MCL1 12 0.43 14.09 2.63 100.00
140 INT309901 Negative_regulation of SAT1 3 0.13 3.96 0 100.00
141 INT313942 Gene_expression of FTO 3 0.62 4.73 0 100.00
142 INT227261 Regulation of hf 5 0.29 5.79 0.21 100.00
143 INT122584 Negative_regulation of Gene_expression of PPARA 56 0.58 37.61 9.76 100.00
144 INT45838 Positive_regulation of LPL 15 0.69 11.33 2 100.00
145 INT6110 Negative_regulation of Gene_expression of Ins1 83 0.56 60.59 16.07 100.00
146 INT195453 Negative_regulation of Gene_expression of SAT1 5 0.42 4.41 0.54 100.00
147 INT126907 Positive_regulation of Gene_expression of CD68 8 0.42 10.94 1.23 100.00
148 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 100.00
149 INT72179 Negative_regulation of Dll1 5 0.33 4.09 3.84 100.00
150 INT296990 Positive_regulation of MLST8 2 0.05 2.89 0.13 100.00
151 INT296995 Regulation of MLST8 2 0.03 3.1 0.13 100.00
152 INT305231 Regulation of Obsty1 1 0.04 5.37 0 100.00
153 INT143743 Positive_regulation of Gene_expression of FAAH 8 0.60 6.42 1.46 100.00
154 INT13370 Negative_regulation of Scn4a 11 0.57 4.05 5.47 100.00
155 INT186786 Positive_regulation of NRIP1 3 0.50 4.81 0.42 100.00
156 INT298812 Regulation of Gene_expression of TUSC5 1 0.61 2.97 0.23 100.00
157 INT122561 Negative_regulation of Gene_expression of Adipoq 12 0.56 14.02 2.26 100.00
158 INT178261 Positive_regulation of Gene_expression of a 23 0.55 14.67 4.07 100.00
159 INT352531 Regulation of Gene_expression of CD68 1 0.51 5.59 0.72 100.00
160 INT198027 Localization of MCL1 5 0.72 7.46 0.51 100.00
161 INT277039 Negative_regulation of Gene_expression of Nppb 1 0.59 4.05 0 100.00
162 INT17034 Positive_regulation of Slc10a2 4 0.41 2.79 0.87 100.00
163 INT9234 Negative_regulation of Gene_expression of IL6 171 0.59 101.61 53.15 100.00
164 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87 100.00
165 INT238863 Regulation of Gene_expression of LIPE 1 0.29 2.61 0 100.00
166 INT138696 Positive_regulation of Ccl2 57 0.67 59.57 19.58 100.00
167 INT24412 Localization of WDTC1 18 0.68 12.45 4.5 100.00
168 INT2274 Regulation of Localization of INS 101 0.62 41.55 34.79 100.00
169 INT125136 Regulation of Adipoq 24 0.56 16.82 7.23 100.00
170 INT95738 Positive_regulation of Phosphorylation of Mapk8 40 0.70 23.46 13.88 100.00
171 INT303962 Phosphorylation of Lep 2 0.80 5.2 0.31 100.00
172 INT26707 Binding of PPAP2A 21 0.35 6.01 7.43 100.00
173 INT770 Regulation of Localization of Gnrhr 127 0.61 17.91 58.23 100.00
174 INT195450 Binding of SAT1 3 0.37 4.11 0.39 100.00
175 INT216519 Gene_expression of Wdtc1 4 0.65 4.02 0.47 100.00
176 INT17086 Binding of HSD11B1 84 0.47 122.28 6.16 100.00
177 INT20914 Positive_regulation of Snai1 13 0.41 3.41 7.69 100.00
178 INT9649 Positive_regulation of LPA 105 0.69 74.75 13.89 100.00
179 INT181185 Localization of Iba1 12 0.49 7.44 1.01 100.00
180 INT67146 Positive_regulation of Gene_expression of Hypism 4 0.17 9.08 1.09 100.00
181 INT2578 Binding of Ins1 74 0.48 33.57 12.92 100.00
182 INT173177 Positive_regulation of Localization of PPARA 21 0.49 12.61 1.74 100.00
183 INT91648 Binding of SPECC1 7 0.48 22.42 19.36 100.00
184 INT124738 Negative_regulation of Positive_regulation of Insr 5 0.23 3.73 1.24 100.00
185 INT227263 Negative_regulation of Gene_expression of Baat 2 0.24 2.78 0.03 100.00
186 INT296973 Regulation of Gene_expression of NRIP1 1 0.45 2.2 0.03 100.00
187 INT305228 Positive_regulation of Obsty1 1 0.07 4.12 0 100.00
188 INT298809 Localization of MLST8 2 0.07 2.17 0.26 100.00
189 INT227279 Negative_regulation of Positive_regulation of hf 1 0.24 2.61 0.04 100.00
190 INT25834 Positive_regulation of Dbp 59 0.68 24.34 9.32 100.00
191 INT9012 Localization of Vip 283 0.81 31.71 106.16 100.00
192 INT138799 Regulation of Gene_expression of Ppara 40 0.60 29.42 6.89 100.00
193 INT217685 Negative_regulation of BMI1 7 0.18 6.01 0.82 100.00
194 INT550 Negative_regulation of LDLR 66 0.43 44.71 3.04 100.00
195 INT227268 Negative_regulation of Transcription of Adipoq 4 0.52 4.93 0.3 100.00
196 INT167270 Negative_regulation of Gene_expression of Lep 13 0.55 5.48 1.19 100.00
197 INT106745 Localization of CRP 65 0.81 66.44 15.21 100.00
198 INT187726 Positive_regulation of Localization of LEP 5 0.50 5.31 0.41 100.00
199 INT88868 Binding of MCS 45 0.40 37.43 7.98 100.00
200 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 100.00
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