D:Obstructive Jaundice

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Disease Term
Synonyms Cholestatic Jaundice, Jaundice Cholestatic, Jaundice Mechanical, Mechanical Jaundice
Documents 765
Hot Single Events 116
Hot Interactions 3

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Obstructive Jaundice. They are ordered first by their relevance to Obstructive Jaundice and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT296179 Pla2g2a Positive_regulation of Apcs 1 0.17 7.13 0.96 91.12
2 INT56008 Binding of FN1 and PTDSS1 1 0.05 0.55 0.15 90.56
3 INT56010 Binding of FN1 and FKBPL 1 0.00 0.54 0.15 89.60
4 INT260739 Mapk14 Regulation of Positive_regulation of Sp1 1 0.01 1.06 0.25 78.20
5 INT260743 Mapk14 Regulation of Gene_expression of Il10 1 0.04 0.99 0.24 78.20
6 INT228530 Gopc Positive_regulation of Gene_expression of Nos2 2 0.22 0.67 0.28 53.20
7 INT228532 Positive_regulation of Gopc Positive_regulation of Ros1 1 0.03 0.55 0.2 50.00
8 INT228531 Gopc Positive_regulation of Ros1 1 0.03 0.55 0.2 50.00
9 INT191241 SST Regulation of SAE1 1 0.05 0.89 0.18 21.00
10 INT185997 Binding of FANCB and fc 2 0.01 2.51 0.63 20.48
11 INT225083 Binding of ETF1 and fc 1 0.00 2.13 0.57 20.48
12 INT225082 Binding of IGHG3 and fc 6 0.01 3.6 0.55 20.48
13 INT83422 Binding of FANCB and IGHG3 3 0.12 5.09 1.22 20.24
14 INT225067 Binding of ETF1 and IGHG3 1 0.03 4.52 1.17 20.24
15 INT225065 Binding of ETF1 and FANCB 1 0.01 2.07 0.59 19.92
16 INT127128 Binding of CNR1 and CNR2 8 0.39 3.98 3.97 5.00
17 INT213026 Hdl1 Positive_regulation of Nos3 5 0.16 7.92 0.73 5.00
18 INT260744 Binding of Ecm1 and Tlr2 1 0.00 0.45 0.39 5.00
19 INT260746 Binding of TLR4 and Ecm1 1 0.02 0.44 0.38 5.00
20 INT260747 Binding of TLR4 and Tlr2 1 0.05 0.44 0.38 5.00
21 INT236955 Binding of Cxcr5 and Cxcl13 1 0.28 2.26 0.34 5.00
22 INT191240 SAE1 Regulation of Localization of INS 1 0.08 1.15 0.3 5.00
23 INT287794 Binding of IGHG3 and AIP 1 0.05 2.8 0.24 5.00
24 INT266646 HMOX2 Regulation of Gene_expression of Hmox1 1 0.00 0.87 0.2 5.00
25 INT355867 Binding of Afp and HCC 1 0.01 2.25 0.14 5.00
26 INT179872 Binding of HGF and MET 7 0.09 4.69 0.07 5.00
27 INT225068 Binding of FCAR and IGHG3 1 0.02 0.27 0.07 5.00
28 INT225081 Binding of FCAR and fc 1 0.00 0.27 0.07 5.00
29 INT225064 Binding of IGHA1 and IGHG3 1 0.01 1.54 0.07 5.00
30 INT288099 Binding of APP and App 1 0.01 1.04 0.05 5.00
31 INT225084 IGHG3 Negative_regulation of fc 1 0.01 0.24 0 5.00
32 INT331909 Binding of ALB and SPARC 1 0.06 2.01 0 5.00
33 INT319320 Binding of EGI and IGF1R 1 0.02 0.85 0 5.00
34 INT320848 Binding of Npc1 and Npc2 1 0.39 0 0 5.00
35 INT319319 Binding of EGFR and KRAS 1 0.22 0.27 0 5.00
36 INT225080 Positive_regulation of IGHG3 Negative_regulation of fc 1 0.01 0.24 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Obstructive Jaundice. They are ordered first by their pain relevance and then by number of times they were reported in Obstructive Jaundice. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT45914 Gene_expression of Apcs 22 0.65 24.25 8.48 100.00
2 INT47079 Localization of Apcs 4 0.75 7.28 1.11 100.00
3 INT60933 Positive_regulation of Apcs 16 0.67 11.69 3.68 100.00
4 INT45913 Positive_regulation of Gene_expression of Apcs 3 0.40 5.27 0.83 100.00
5 INT287799 Positive_regulation of Gene_expression of AIP 1 0.42 7.39 1.19 100.00
6 INT25336 Localization of Pla2g2a 5 0.72 4.97 1.17 99.96
7 INT5254 Positive_regulation of Pla2g2a 22 0.68 10.42 6.37 99.96
8 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68 99.86
9 INT25020 Gene_expression of Pla2g2a 11 0.76 5.97 1.48 99.86
10 INT36489 Regulation of Apcs 12 0.58 10.6 2.78 99.80
11 INT24141 Negative_regulation of Apcs 24 0.59 16.82 8.29 99.80
12 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 99.80
13 INT102107 Negative_regulation of Gene_expression of Bax 30 0.57 29.48 7.33 99.78
14 INT25334 Negative_regulation of Pla2g2a 16 0.56 9.01 4.23 99.72
15 INT112989 Gene_expression of AIP 3 0.56 25.4 4.23 99.64
16 INT35329 Positive_regulation of KRTAP19-9P 15 0.59 12.55 2.98 99.58
17 INT100423 Gene_expression of Bax 141 0.75 98.43 24.48 99.48
18 INT1624 Gene_expression of Cea 212 0.76 180.44 34.21 99.36
19 INT134442 Transcription of Bax 14 0.67 7.6 1.9 99.16
20 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 98.64
21 INT184750 Positive_regulation of Car9 3 0.08 6.38 1.27 98.24
22 INT1554 Positive_regulation of RNASE1 10 0.67 9.44 1.78 98.16
23 INT52800 Negative_regulation of Gene_expression of Tnf 142 0.59 92.27 55.47 98.08
24 INT58400 Negative_regulation of Tnf 182 0.59 129.97 71 98.08
25 INT106274 Positive_regulation of Syt1 16 0.67 9.76 4.1 97.40
26 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 97.32
27 INT2355 Negative_regulation of Klkb1 6 0.26 2.5 1.3 97.28
28 INT77434 Positive_regulation of Gene_expression of Nos2 151 0.69 96.76 38.94 97.28
29 INT205260 Binding of Pbd1 1 0.05 0.25 0 97.20
30 INT100861 Binding of CRP 179 0.48 175.2 26.45 96.68
31 INT26606 Gene_expression of RNASE1 19 0.65 7.18 1.46 96.60
32 INT19966 Positive_regulation of C9orf3 19 0.67 21.88 4.38 96.60
33 INT90792 Localization of Il10 144 0.80 87.88 30.03 96.48
34 INT191017 Localization of Cd79a 28 0.56 13.94 2.55 96.48
35 INT121801 Binding of Aip 18 0.36 24.1 5.26 96.48
36 INT242011 Localization of Cdkn2a 4 0.73 2.49 0.54 96.46
37 INT285 Positive_regulation of Salpa1 73 0.68 61.47 9.19 96.16
38 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 96.00
39 INT66280 Gene_expression of Nos2 534 0.78 330.78 157.07 95.92
40 INT23654 Binding of SPINK1 27 0.48 30.85 11.53 95.92
41 INT118009 Positive_regulation of Binding of SPINK1 1 0.22 1.04 0 95.92
42 INT173505 Localization of Hand2 63 0.57 45.32 13.66 95.76
43 INT66753 Negative_regulation of Positive_regulation of Tnf 45 0.59 35.28 22.33 95.64
44 INT22708 Gene_expression of MUC1 297 0.78 232.71 24.19 95.36
45 INT49995 Positive_regulation of Gene_expression of Tnf 187 0.70 125.07 70.54 95.20
46 INT194848 Negative_regulation of Localization of Il10 11 0.36 8.29 3.38 95.20
47 INT70916 Binding of Thim 13 0.02 8.35 1.72 94.80
48 INT118008 Positive_regulation of Binding of Thim 1 0.00 1.03 0 94.80
49 INT10166 Localization of Tnf 237 0.81 153.95 88.64 94.56
50 INT49266 Positive_regulation of Arigg4 37 0.47 53.79 11.2 94.28
51 INT13353 Positive_regulation of Tnf 332 0.70 248.75 148.1 93.88
52 INT63975 Positive_regulation of Il10 175 0.68 134.13 54.69 93.80
53 INT68244 Positive_regulation of Ighg1 60 0.61 48.86 5.01 93.44
54 INT205262 Gene_expression of Pbd1 1 0.10 0.43 0.13 93.36
55 INT8546 Positive_regulation of MUC16 99 0.69 74.98 11.26 93.20
56 INT11032 Positive_regulation of Positive_regulation of MUC16 2 0.49 2.38 0.67 93.20
57 INT111461 Positive_regulation of hb 30 0.38 21.08 2.1 93.12
58 INT505 Positive_regulation of GPT 89 0.67 69.38 14.94 93.04
59 INT320841 Positive_regulation of Chit1 1 0.02 0.82 0.07 92.92
60 INT14026 Positive_regulation of Igh-6 24 0.68 10.84 4.32 92.88
61 INT106782 Negative_regulation of Positive_regulation of Igh-6 2 0.42 0.93 0.28 92.88
62 INT39416 Gene_expression of Cd79a 81 0.64 45.17 6.08 92.64
63 INT10510 Negative_regulation of Igh-6 13 0.45 10.37 2.68 92.36
64 INT56012 Negative_regulation of PTDSS1 2 0.05 0.67 0.5 92.04
65 INT38546 Negative_regulation of Gene_expression of IV 1 0.38 1.19 0.18 91.72
66 INT38542 Negative_regulation of IV 1 0.51 1.19 0.17 91.72
67 INT78248 Negative_regulation of Cdkn2a 17 0.59 15.15 2.8 91.58
68 INT613 Gene_expression of Alb 268 0.78 149.84 42.78 91.44
69 INT38545 Gene_expression of IV 3 0.53 2.89 0.41 91.12
70 INT103378 Binding of Spink1 24 0.40 15.3 6.19 91.04
71 INT19967 Gene_expression of C9orf3 18 0.75 26.51 4.6 90.92
72 INT57431 Binding of PIAS1 4 0.30 4.35 1.94 90.76
73 INT56011 Binding of PTDSS1 1 0.04 0.54 0.12 90.56
74 INT1542 Binding of Prss1 8 0.30 4.25 3.74 90.40
75 INT28507 Regulation of ANPEP 4 0.26 1.84 0.5 90.24
76 INT235516 Positive_regulation of Localization of Hand2 4 0.36 3.04 0.97 89.68
77 INT173974 Positive_regulation of Localization of Il10 25 0.68 16.81 5.87 89.68
78 INT56594 Positive_regulation of Localization of Il4 17 0.48 10.17 4.15 89.68
79 INT56013 Binding of FKBPL 1 0.00 0.54 0.12 89.60
80 INT20379 Localization of Il4 85 0.73 51.22 20.55 88.52
81 INT131931 Binding of KRT7 13 0.36 19.24 0.5 88.24
82 INT171147 Binding of Syt1 7 0.35 6.11 1.36 88.04
83 INT345972 Binding of HGD 1 0.02 1.95 0.08 87.76
84 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 87.52
85 INT6510 Gene_expression of AFP 130 0.78 119.2 9.19 87.12
86 INT172458 Regulation of Gopc 155 0.53 62.57 24.86 87.08
87 INT52749 Gene_expression of alp 24 0.44 12.84 5.97 86.96
88 INT16349 Positive_regulation of alp 25 0.60 16.74 4.34 86.96
89 INT205184 Positive_regulation of Positive_regulation of alp 2 0.11 1.25 0.16 86.96
90 INT4479 Negative_regulation of Positive_regulation of REN 17 0.56 6.1 3.27 86.92
91 INT8067 Negative_regulation of Binding of AGT 12 0.25 10.33 1.39 86.92
92 INT193154 Regulation of CRAMP1L 5 0.28 3.04 0.34 86.64
93 INT8065 Binding of AGT 54 0.48 20.54 10.85 86.40
94 INT59247 Negative_regulation of Localization of Pla2g2a 2 0.39 1.27 0.34 85.72
95 INT105114 Gene_expression of Arigg4 16 0.52 21.88 4.56 85.68
96 INT11340 Positive_regulation of SLC17A5 120 0.67 113.52 14.5 85.40
97 INT375 Positive_regulation of REN 293 0.70 152.46 47.55 85.24
98 INT6511 Positive_regulation of AFP 76 0.70 70.15 7.28 84.32
99 INT260162 Gene_expression of PPPD1 4 0.55 4.26 0.04 84.32
100 INT95787 Positive_regulation of Mapk1 568 0.70 226.51 220.94 84.20
101 INT96913 Positive_regulation of Mapk8 179 0.69 130.44 32.2 84.20
102 INT96917 Positive_regulation of Mapk14 261 0.70 173.29 88.79 84.20
103 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 83.28
104 INT3041 Positive_regulation of MIA3 34 0.56 21.11 6.49 83.28
105 INT60694 Gene_expression of Il10 567 0.78 369.48 143.69 82.92
106 INT12265 Positive_regulation of IgG 168 0.63 104.89 19.76 82.80
107 INT206007 Positive_regulation of Localization of Cd79a 5 0.35 3.32 0.81 82.56
108 INT79140 Binding of HCC 36 0.31 46.96 1.87 82.00
109 INT8224 Gene_expression of CHGA 73 0.75 53.63 12.31 81.92
110 INT78659 Gene_expression of Thim 17 0.28 14.34 4.4 81.76
111 INT20665 Gene_expression of ACE 87 0.78 51.71 14.19 81.40
112 INT191244 Localization of SAE1 1 0.12 2.81 0.09 81.16
113 INT82743 Gene_expression of SPINK1 48 0.78 44.28 8.77 81.12
114 INT274238 Positive_regulation of AIP 2 0.42 8.14 0.97 80.88
115 INT24891 Gene_expression of SYP 55 0.75 45.76 7.53 80.68
116 INT56651 Binding of HLA-DRB1 58 0.48 52.25 13.68 80.48
117 INT812 Localization of INS 1026 0.81 515.6 145.31 79.52
118 INT76924 Positive_regulation of Slc17a5 71 0.70 41.21 19.31 79.20
119 INT8798 Positive_regulation of Csrp1 61 0.69 63.86 14.14 79.12
120 INT12951 Negative_regulation of Cat 126 0.57 64.39 20.61 78.64
121 INT20664 Binding of ACE 60 0.48 35.27 9.16 78.20
122 INT72446 Negative_regulation of Binding of ACE 4 0.42 2.48 0.62 78.20
123 INT21609 Positive_regulation of RASGRP1 58 0.50 40.78 5.47 77.92
124 INT287797 Phosphorylation of AIP 1 0.78 2.04 0.16 77.36
125 INT91891 Gene_expression of Kit 268 0.78 158.89 22.67 76.20
126 INT52937 Gene_expression of Cd68 37 0.67 31.33 7.54 76.20
127 INT23317 Gene_expression of Spn 20 0.48 14.51 4.01 76.20
128 INT91890 Positive_regulation of Kit 36 0.50 25.44 3.06 76.20
129 INT83295 Positive_regulation of Cd68 21 0.39 14.55 2.46 76.20
130 INT19964 Negative_regulation of Positive_regulation of C9orf3 3 0.42 4.06 0.67 75.92
131 INT102985 Binding of AFF1 1 0.02 1.18 0.39 75.16
132 INT20052 Negative_regulation of UGT1A1 12 0.58 4.51 4.29 75.00
133 INT140682 Positive_regulation of GIF 4 0.49 0.87 0.15 75.00
134 INT8579 Gene_expression of Apoa1 13 0.76 35.89 7.21 75.00
135 INT743 Negative_regulation of Salpa1 16 0.57 8.75 3.1 75.00
136 INT39212 Binding of Ttr 14 0.48 9.62 2.31 75.00
137 INT156484 Binding of Apoa1 4 0.47 6.78 1.63 75.00
138 INT12890 Gene_expression of Ttr 15 0.63 7.68 1.6 75.00
139 INT86669 Positive_regulation of HOMER1 2 0.30 1.37 0.31 75.00
140 INT41559 Positive_regulation of Sp1 7 0.45 2.65 3.24 74.88
141 INT134967 Gene_expression of Ecm1 66 0.29 38.4 7.16 74.64
142 INT128609 Gene_expression of C1S 18 0.75 17.36 0.98 74.40
143 INT89 Positive_regulation of Gast 187 0.70 80.49 42.07 74.08
144 INT287798 Localization of AIP 1 0.63 5.96 1.31 73.80
145 INT340339 Negative_regulation of UGT1A 1 0.42 1.56 0.21 73.68
146 INT37335 Gene_expression of Nsdhl 45 0.51 24.36 4.58 73.04
147 INT99410 Positive_regulation of UGT1A1 10 0.45 2.2 2.07 72.96
148 INT138440 Gene_expression of Spt 4 0.47 4.94 0.5 71.52
149 INT60695 Positive_regulation of Gene_expression of Il10 154 0.70 120.28 43.07 71.32
150 INT1125 Positive_regulation of IGHG3 130 0.69 112.07 13.18 71.32
151 INT56291 Gene_expression of Ros1 503 0.63 274.12 81.5 70.96
152 INT19545 Positive_regulation of IV 5 0.61 4.22 0.83 70.00
153 INT4004 Gene_expression of IGHG3 321 0.71 221.03 42.33 69.72
154 INT16449 Binding of IGHG3 67 0.48 39.55 10.59 69.72
155 INT8066 Binding of RASGRP1 10 0.36 4.65 0.58 67.76
156 INT148671 Gene_expression of Aip 26 0.63 24.32 3.91 66.60
157 INT143489 Gene_expression of Ggt6 3 0.24 1.67 0.28 64.24
158 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 62.36
159 INT75540 Positive_regulation of TH1L 62 0.67 43.45 15.02 62.36
160 INT38543 Positive_regulation of Positive_regulation of IV 1 0.44 1.18 0.16 62.16
161 INT9223 Localization of Ighg1 22 0.78 11.03 3.67 61.00
162 INT162249 Gene_expression of Hist1h2aa 8 0.12 6.46 4.35 60.84
163 INT48244 Gene_expression of Il4 172 0.76 132.38 73.42 60.64
164 INT48895 Gene_expression of Il10 333 0.78 221.2 138.52 60.28
165 INT6852 Localization of TNF 883 0.81 705.95 270.84 59.76
166 INT38544 Regulation of IV 1 0.54 1.13 0.15 59.52
167 INT260738 Gene_expression of Ugt1a2 2 0.02 2.22 0.5 58.56
168 INT92100 Binding of Smad4 5 0.31 2.23 0.3 57.08
169 INT34809 Gene_expression of Ec 36 0.15 15.7 3.24 56.32
170 INT193156 Gene_expression of CRAMP1L 17 0.42 10.96 0.18 54.84
171 INT15888 Positive_regulation of Nbr1 42 0.69 35.76 10.48 54.72
172 INT724 Negative_regulation of Alb 151 0.59 93.57 29.65 54.32
173 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 53.60
174 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 53.60
175 INT671 Positive_regulation of Cea 221 0.69 164.5 47.79 53.60
176 INT15529 Gene_expression of GCG 51 0.75 18.55 8.35 53.24
177 INT14470 Gene_expression of HCC 83 0.67 110.55 4.61 52.80
178 INT179814 Positive_regulation of Protein_catabolism of Ecm1 5 0.06 3.38 0.85 52.64
179 INT179810 Protein_catabolism of Ecm1 30 0.11 18.28 5.75 52.24
180 INT7207 Regulation of HBG1 27 0.60 22.1 1.12 52.24
181 INT50061 Negative_regulation of Edn3 4 0.58 0.77 0.65 52.24
182 INT68216 Binding of NF1 40 0.48 51.24 4.59 51.68
183 INT141185 Regulation of Ros1 30 0.24 20.73 8.88 51.20
184 INT160828 Regulation of Gene_expression of Ros1 29 0.21 13.97 3.75 51.20
185 INT170332 Gene_expression of IFN1@ 477 0.75 275.21 69.65 50.68
186 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 50.32
187 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 50.32
188 INT17564 Gene_expression of Gpt 322 0.75 208.51 60.36 50.00
189 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 50.00
190 INT92837 Negative_regulation of Gene_expression of Nos2 116 0.59 59.67 31.82 50.00
191 INT34729 Positive_regulation of IFN1@ 233 0.67 128.04 30.38 50.00
192 INT145426 Positive_regulation of Ros1 185 0.56 106.76 27.21 50.00
193 INT170051 Positive_regulation of Gene_expression of Gopc 150 0.43 56.75 16.93 50.00
194 INT14152 Gene_expression of Slc17a5 46 0.61 20.01 15.9 50.00
195 INT30738 Negative_regulation of Gene_expression of ALB 32 0.59 19.01 5.04 50.00
196 INT170755 Positive_regulation of Positive_regulation of IFN1@ 17 0.67 8.72 3.65 50.00
197 INT9884 Localization of CD79A 41 0.78 21.75 3.06 50.00
198 INT98224 Negative_regulation of Gene_expression of Cd79a 6 0.35 3.35 1.74 50.00
199 INT190519 Positive_regulation of Positive_regulation of Ros1 14 0.32 9.99 1.52 50.00
200 INT190335 Negative_regulation of Positive_regulation of IFN1@ 16 0.42 4.6 1.29 50.00
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