D:Obstructive Sleep Apnea

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Disease Term
Synonyms APNEA OBSTRUCTIVE SLEEP, Apneas Obstructive Sleep, Obstructive Sleep Apnea Syndrome, Obstructive Sleep Apneas, SLEEP APNEA SYNDROME OBSTRUCTIVE, Sleep Apneas Obstructive, SYNDROME OBSTRUCTIVE SLEEP APNEA, SYNDROME SLEEP APNEA OBSTRUCTIVE, Syndrome Upper Airway Resistance Sleep Apnea, Upper Airway Resistance Sleep Apnea Syndrome
Documents 156
Hot Single Events 73
Hot Interactions 4

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Obstructive Sleep Apnea. They are ordered first by their relevance to Obstructive Sleep Apnea and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT267707 Binding of Tnf and ARID1B 2 0.20 8.2 0.54 100.00
2 INT267684 Binding of INS and ARID1B 3 0.10 6.08 0.09 100.00
3 INT267685 Binding of CENPJ and ARID1B 1 0.09 0.58 0.04 100.00
4 INT256605 FPR1 Positive_regulation of MTOR 1 0.01 2.18 0 98.64
5 INT267686 Binding of RYBP and CENPJ 1 0.01 0.12 0.03 56.92
6 INT273024 Binding of FXYD1 and RLS 1 0.04 1.24 0.21 5.00
7 INT345966 Binding of Arid1a and al44 1 0.00 1.56 0.05 5.00
8 INT345965 Binding of Lep and al44 1 0.01 1.43 0.05 5.00
9 INT336576 Binding of HCRTR1 and IGHG3 1 0.01 5.01 0 5.00
10 INT336574 Binding of CD40LG and HCRTR1 1 0.05 0.1 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Obstructive Sleep Apnea. They are ordered first by their pain relevance and then by number of times they were reported in Obstructive Sleep Apnea. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT154104 Binding of ARID1B 47 0.39 69.82 1.49 100.00
2 INT249049 Positive_regulation of ARID1B 14 0.56 24.77 0.71 100.00
3 INT35349 Gene_expression of CENPJ 52 0.57 25.36 2.54 100.00
4 INT147792 Gene_expression of COPD 230 0.70 287.13 24.1 100.00
5 INT267698 Gene_expression of ARID1B 18 0.63 20.47 0.47 100.00
6 INT267703 Regulation of ARID1B 6 0.21 6.85 0.45 100.00
7 INT267701 Positive_regulation of Binding of ARID1B 1 0.19 2.83 0 100.00
8 INT267702 Localization of ARID1B 1 0.29 1.45 0.04 100.00
9 INT154102 Negative_regulation of ARID1B 5 0.35 6.45 0.1 100.00
10 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 100.00
11 INT100861 Binding of CRP 179 0.48 175.2 26.45 100.00
12 INT267706 Positive_regulation of Protein_catabolism of ARID1B 1 0.19 1.8 0 100.00
13 INT267705 Protein_catabolism of ARID1B 2 0.71 3.18 0 100.00
14 INT125312 Positive_regulation of COPD 134 0.59 162.55 20.27 100.00
15 INT267704 Positive_regulation of Positive_regulation of ARID1B 1 0.19 1.6 0.03 100.00
16 INT20664 Binding of ACE 60 0.48 35.27 9.16 100.00
17 INT179688 Negative_regulation of Gene_expression of COPD 13 0.35 16.06 0.97 100.00
18 INT61784 Positive_regulation of CENPJ 27 0.51 11.46 2.28 99.96
19 INT3881 Positive_regulation of Protein_catabolism of F13A1 21 0.41 20 3.28 99.84
20 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 99.80
21 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 99.72
22 INT74563 Positive_regulation of Gene_expression of ROS1 258 0.61 168.18 34.08 99.60
23 INT41721 Negative_regulation of MTOR 40 0.58 32.49 2.83 99.52
24 INT267699 Positive_regulation of Binding of MAS1 1 0.03 0.45 0.06 99.44
25 INT177642 Positive_regulation of Gene_expression of CENPJ 5 0.30 3.25 0.07 99.42
26 INT223599 Regulation of MTOR 14 0.42 8.52 0.49 99.40
27 INT1888 Protein_catabolism of F13A1 97 0.99 63.48 14.82 99.32
28 INT899 Gene_expression of F13A1 122 0.70 78.02 16.26 99.32
29 INT78050 Positive_regulation of Positive_regulation of Selp 3 0.43 3.63 1.02 99.28
30 INT71510 Positive_regulation of Selp 47 0.68 30.43 12.8 99.28
31 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 99.22
32 INT131488 Binding of MAS1 9 0.36 8.49 1.01 98.96
33 INT92343 Negative_regulation of CENPJ 20 0.57 6.25 0.2 98.90
34 INT27813 Regulation of CENPJ 12 0.29 14.26 0.99 98.80
35 INT156201 Negative_regulation of Gene_expression of MTOR 6 0.58 7.7 0.36 98.56
36 INT41719 Gene_expression of MTOR 27 0.77 19.43 1.44 98.56
37 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 98.12
38 INT172808 Positive_regulation of Positive_regulation of ROS1 35 0.40 31.39 2.27 97.88
39 INT14997 Positive_regulation of FPR1 21 0.66 9.82 13.2 97.76
40 INT69441 Regulation of Gene_expression of ROS1 38 0.50 26.78 6.78 97.36
41 INT13353 Positive_regulation of Tnf 332 0.70 248.75 148.1 97.04
42 INT70970 Binding of COPD 144 0.42 180.34 18.29 96.76
43 INT6652 Negative_regulation of FPR1 11 0.42 5.29 7.41 96.72
44 INT22962 Gene_expression of FXYD1 2 0.58 3.32 1.12 96.56
45 INT2129 Positive_regulation of F2 83 0.70 58.95 12.63 96.24
46 INT19 Regulation of Gnrhr 131 0.62 36.4 55.66 95.80
47 INT15991 Gene_expression of FPR1 27 0.59 8.22 9.01 95.76
48 INT256615 Positive_regulation of Gene_expression of FPR1 4 0.29 1.27 0.32 95.76
49 INT75742 Binding of RLS 86 0.42 95.27 19.04 95.56
50 INT254724 Negative_regulation of DHFR 2 0.42 3.92 1.39 95.04
51 INT219535 Negative_regulation of Localization of CENPJ 2 0.41 1.01 0.05 94.72
52 INT161574 Localization of CENPJ 7 0.73 6.11 1.54 94.72
53 INT106169 Localization of RHOJ 3 0.78 1.73 0.56 93.52
54 INT256620 Gene_expression of RHOJ 1 0.08 0.25 0 93.52
55 INT256612 Negative_regulation of RHOJ 1 0.05 0.25 0 93.52
56 INT162064 Gene_expression of PKD2L1 12 0.63 2.71 1.1 92.88
57 INT256618 Localization of PKD2L1 2 0.73 0.25 0 92.88
58 INT213719 Negative_regulation of PKD2L1 2 0.15 0.8 0 92.88
59 INT217732 Localization of MTOR 11 0.56 3.19 0.03 92.48
60 INT256619 Gene_expression of C6orf108 1 0.08 0.25 0 92.48
61 INT256616 Localization of C6orf108 1 0.04 0.25 0 92.48
62 INT256613 Negative_regulation of C6orf108 1 0.07 0.25 0 92.48
63 INT149762 Regulation of MAS1 8 0.31 5.34 1.61 92.24
64 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 92.08
65 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 92.08
66 INT60436 Negative_regulation of COPD 76 0.37 84.22 9.08 92.04
67 INT8483 Positive_regulation of Positive_regulation of TNF 73 0.67 60.35 22.03 91.76
68 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 90.88
69 INT148341 Gene_expression of MAS1 9 0.65 4.19 0.68 90.08
70 INT59871 Negative_regulation of Gene_expression of FPR1 2 0.22 0.88 0.23 88.28
71 INT89610 Binding of EFS 2 0.36 2 0.2 88.00
72 INT236711 Gene_expression of Bcl6 15 0.30 12.98 0.58 87.72
73 INT44168 Positive_regulation of Cenpj 8 0.60 0.39 0.07 86.32
74 INT263095 Transcription of COPD 3 0.53 2.78 0.33 78.48
75 INT16234 Positive_regulation of CFH 25 0.50 26.05 3.33 76.00
76 INT102658 Negative_regulation of Gene_expression of CSF2 42 0.50 38.63 8.32 74.04
77 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 73.64
78 INT177643 Binding of CENPJ 12 0.36 8.59 0.22 64.00
79 INT52904 Positive_regulation of LTF 21 0.67 15.58 5.78 63.00
80 INT106057 Negative_regulation of Hcrt 27 0.57 15.5 3.47 58.48
81 INT106055 Negative_regulation of Gene_expression of Hcrt 15 0.46 5.64 2.09 58.48
82 INT148884 Negative_regulation of HCRTR1 7 0.23 7.23 0.53 58.48
83 INT148886 Negative_regulation of Gene_expression of HCRTR1 2 0.23 3.42 0.05 58.48
84 INT148883 Gene_expression of HCRTR1 8 0.36 24.82 1.35 58.00
85 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 57.44
86 INT153300 Negative_regulation of Gene_expression of CRP 48 0.58 39.97 7.58 57.44
87 INT106056 Gene_expression of Hcrt 77 0.76 35.35 8.16 57.36
88 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 57.16
89 INT9951 Gene_expression of ANGPTL5 45 0.53 37.2 6.44 57.16
90 INT11685 Regulation of CSF2 99 0.59 58.82 15.9 56.64
91 INT2560 Gene_expression of Nr2e1 2 0.53 2.5 0.16 56.00
92 INT194166 Regulation of Regulation of LTF 1 0.07 0.57 0.09 52.04
93 INT148882 Regulation of LTF 9 0.12 4.8 0.44 51.80
94 INT194168 Protein_catabolism of LTF 3 0.67 2.02 0.38 51.16
95 INT70744 Regulation of CFH 12 0.41 7.38 0.8 51.04
96 INT194167 Protein_catabolism of CFH 2 0.59 0.63 0.09 51.04
97 INT150867 Regulation of COPD 54 0.48 71.38 8.8 50.00
98 INT142117 Regulation of Runx2 6 0.61 2.75 0.22 38.64
99 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 33.04
100 INT4004 Gene_expression of IGHG3 321 0.71 221.03 42.33 33.04
101 INT2120 Gene_expression of CD79A 159 0.78 111.69 17.16 33.04
102 INT1020 Negative_regulation of BCHE 109 0.59 44.86 16.4 19.80
103 INT310648 Negative_regulation of Negative_regulation of BCHE 2 0.27 1.79 0.59 19.80
104 INT1579 Gene_expression of PRL 279 0.78 119.2 55.41 14.92
105 INT196324 Localization of Cyp2b10 5 0.73 2.81 0.13 12.56
106 INT117117 Positive_regulation of REM1 12 0.40 10.1 3.33 10.96
107 INT47027 Positive_regulation of BCHE 6 0.50 2.32 1.09 10.96
108 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
109 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 5.00
110 INT425 Localization of PRL 455 0.81 189.64 144.8 5.00
111 INT695 Binding of POMC 304 0.48 56.66 126.85 5.00
112 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 5.00
113 INT133211 Gene_expression of Runx1 169 0.77 83.4 76.16 5.00
114 INT6486 Positive_regulation of Tnf 168 0.70 123.47 66.05 5.00
115 INT3213 Gene_expression of Ins1 511 0.76 357.59 53.32 5.00
116 INT173693 Localization of Gopc 249 0.65 70.49 38.81 5.00
117 INT2416 Negative_regulation of MAOA 92 0.59 42.24 36.5 5.00
118 INT3679 Gene_expression of AVP 171 0.78 72.9 35.23 5.00
119 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 5.00
120 INT101483 Gene_expression of Lep 159 0.78 104.77 25.12 5.00
121 INT682 Negative_regulation of AVP 97 0.59 50.67 23.91 5.00
122 INT18010 Positive_regulation of CD40LG 122 0.70 100.8 18.46 5.00
123 INT1578 Negative_regulation of Localization of PRL 52 0.59 20.62 17.18 5.00
124 INT54924 Gene_expression of RLS 67 0.62 83.2 14.25 5.00
125 INT1125 Positive_regulation of IGHG3 130 0.69 112.07 13.18 5.00
126 INT142735 Regulation of RLS 33 0.53 45.83 11.35 5.00
127 INT11936 Positive_regulation of Positive_regulation of Il6 34 0.50 26.85 10.59 5.00
128 INT47860 Negative_regulation of Cyp1a2 20 0.57 6.06 10 5.00
129 INT101481 Positive_regulation of Lep 81 0.69 62.59 9.95 5.00
130 INT97891 Gene_expression of Ghrl 108 0.77 24.85 9.7 5.00
131 INT147452 Gene_expression of ADCYAP1 14 0.77 12.54 9.28 5.00
132 INT7813 Regulation of SRI 25 0.61 6.18 8.13 5.00
133 INT107129 Positive_regulation of RLS 46 0.60 40.1 8.09 5.00
134 INT90603 Positive_regulation of Ahr 103 0.69 58.65 7.73 5.00
135 INT200874 Positive_regulation of Localization of Gopc 27 0.38 5.69 7.5 5.00
136 INT58365 Gene_expression of LTF 51 0.78 44.14 7.25 5.00
137 INT18340 Gene_expression of CRX 16 0.22 13.85 7.13 5.00
138 INT7205 Positive_regulation of HBG1 65 0.69 40.35 6.37 5.00
139 INT11154 Binding of EGFR 149 0.48 96.23 6.29 5.00
140 INT83451 Positive_regulation of Gene_expression of CD40LG 26 0.60 22.81 6.25 5.00
141 INT84965 Gene_expression of MAOA 15 0.75 6.9 6.06 5.00
142 INT83734 Negative_regulation of RLS 24 0.50 35.75 5.66 5.00
143 INT101482 Negative_regulation of Lep 53 0.54 33.59 5.65 5.00
144 INT6487 Positive_regulation of Positive_regulation of Tnf 21 0.56 16.06 5.64 5.00
145 INT91338 Binding of Lep 31 0.48 26.86 5.39 5.00
146 INT74250 Negative_regulation of Gene_expression of Ins1 47 0.40 39.27 5.37 5.00
147 INT125242 Localization of RLS 15 0.64 15.87 4.99 5.00
148 INT101925 Binding of Drd1a 9 0.43 1.82 4.97 5.00
149 INT49292 Positive_regulation of Cyp1a2 17 0.69 6.16 4.96 5.00
150 INT11158 Positive_regulation of Gene_expression of EGFR 165 0.70 131.26 4.93 5.00
151 INT11565 Gene_expression of Tf 24 0.68 5.89 4.36 5.00
152 INT34624 Negative_regulation of REM1 22 0.38 9.25 4.22 5.00
153 INT72747 Localization of IgG 55 0.53 30.88 4.19 5.00
154 INT76714 Binding of Drd3 9 0.37 2.33 4.09 5.00
155 INT163581 Localization of Lep 27 0.79 18.99 4.08 5.00
156 INT3127 Gene_expression of SRI 38 0.68 26.29 3.82 5.00
157 INT174054 Positive_regulation of Gene_expression of Lep 25 0.69 21.3 3.72 5.00
158 INT226114 Binding of Ghrl 18 0.36 4.34 3.54 5.00
159 INT16236 Negative_regulation of CFH 31 0.57 19.59 3.36 5.00
160 INT147572 Gene_expression of Ahr 73 0.75 38.99 3.15 5.00
161 INT44661 Regulation of Ahr 15 0.45 12.69 2.79 5.00
162 INT45253 Positive_regulation of Ltf 20 0.69 10.22 2.77 5.00
163 INT132411 Positive_regulation of Ghrl 25 0.69 12.05 2.59 5.00
164 INT142120 Gene_expression of Runx2 45 0.77 15.76 2.55 5.00
165 INT244283 Negative_regulation of Gene_expression of MAOA 2 0.27 1.7 2.5 5.00
166 INT1829 Gene_expression of CFH 71 0.75 64.24 2.49 5.00
167 INT229111 Localization of SLC6A3 5 0.68 1.12 2.48 5.00
168 INT122656 Gene_expression of MTNR1A 21 0.75 6.37 2.46 5.00
169 INT44880 Gene_expression of REM1 21 0.30 5.3 2.43 5.00
170 INT81154 Gene_expression of HCRT 10 0.75 5.32 2.22 5.00
171 INT208561 Gene_expression of Shh 51 0.78 9.57 1.77 5.00
172 INT97892 Positive_regulation of Gene_expression of Ghrl 31 0.49 13.43 1.7 5.00
173 INT62127 Localization of SRI 12 0.45 10.21 1.54 5.00
174 INT19432 Positive_regulation of Gene_expression of CD79A 14 0.45 13.49 1.49 5.00
175 INT7812 Negative_regulation of SRI 10 0.59 4.28 1.46 5.00
176 INT119520 Gene_expression of TXK 19 0.19 17.54 1.45 5.00
177 INT16153 Gene_expression of Cenpj 7 0.77 2.56 1.42 5.00
178 INT244284 Binding of SLC18A2 1 0.23 1.87 1.34 5.00
179 INT167270 Negative_regulation of Gene_expression of Lep 13 0.55 5.48 1.19 5.00
180 INT43484 Binding of Runx2 7 0.37 3.22 0.95 5.00
181 INT267808 Positive_regulation of Gene_expression of RLS 4 0.41 5.96 0.94 5.00
182 INT17807 Positive_regulation of PDGFC 4 0.06 3.28 0.86 5.00
183 INT89368 Positive_regulation of Tf 7 0.34 3.62 0.83 5.00
184 INT213471 Positive_regulation of Localization of Lep 4 0.48 2.65 0.74 5.00
185 INT99281 Negative_regulation of HCRT 3 0.57 2.26 0.71 5.00
186 INT142123 Positive_regulation of Gene_expression of Runx2 17 0.64 4.81 0.65 5.00
187 INT345957 Positive_regulation of Binding of Lep 2 0.38 2.03 0.6 5.00
188 INT232798 Positive_regulation of Gene_expression of Shh 7 0.70 1.49 0.44 5.00
189 INT189927 Gene_expression of Arid1a 8 0.59 9.03 0.43 5.00
190 INT136180 Binding of MTOR 9 0.35 5.01 0.38 5.00
191 INT130105 Positive_regulation of HCRTR1 3 0.27 6.47 0.38 5.00
192 INT273025 Phosphorylation of RLS 1 0.67 4.2 0.38 5.00
193 INT345950 Positive_regulation of Gene_expression of Arid1a 1 0.12 3.63 0.37 5.00
194 INT273027 Regulation of Negative_regulation of FXYD1 1 0.05 1.19 0.35 5.00
195 INT247999 Negative_regulation of FXYD1 2 0.06 1.75 0.35 5.00
196 INT345951 Negative_regulation of Arid1a 1 0.10 6.11 0.33 5.00
197 INT154074 Positive_regulation of Gene_expression of Tf 4 0.46 1.64 0.28 5.00
198 INT336583 Positive_regulation of Gene_expression of HCRTR1 1 0.27 3.25 0.26 5.00
199 INT189913 Positive_regulation of Arid1a 4 0.44 1.82 0.26 5.00
200 INT295943 Negative_regulation of MTNR1A 4 0.21 2.66 0.24 5.00
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