D:Obstructive Uropathy

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Disease Term
Synonyms Bladder Neck Obstruction, Bladder Neck Obstructions, Neck Obstruction Bladder, Neck Obstructions Bladder, Obstruction Bladder Neck, Obstructions Bladder Neck, Urinary Obstruction, Urinary Tract Obstruction, Urinary Tract Obstruction Disorder
Documents 236
Hot Single Events 13
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Obstructive Uropathy. They are ordered first by their relevance to Obstructive Uropathy and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT252902 PTTG1 Regulation of MMP2 1 0.01 1.5 0.14 5.00
2 INT253009 Igf1 Regulation of PTTG1 1 0.03 0.44 0.13 5.00
3 INT253015 Egf Regulation of PTTG1 1 0.02 0.44 0.13 5.00
4 INT252901 PTTG1 Regulation of Gene_expression of TSC1 1 0.00 1.61 0.13 5.00
5 INT253023 Binding of PTTG1 and Myc 1 0.16 0.22 0.04 5.00
6 INT252897 Binding of PTTG1IP and PTTG1 1 0.04 0.15 0.04 5.00
7 INT252892 PTTG1IP Regulation of PTTG1 1 0.05 0.49 0.04 5.00
8 INT283226 Binding of ACE and CC2D1A 1 0.11 2.37 0.04 5.00
9 INT253017 PTTG1IP Regulation of Regulation of Fgf2 1 0.03 0.49 0.04 5.00
10 INT253010 Binding of PTTG1 and Fgf2 1 0.07 0.51 0.03 5.00
11 INT253003 Pttg1 Regulation of Gene_expression of Id3 1 0.08 0.07 0 5.00
12 INT253004 Anapc1 Positive_regulation of Binding of Pttg1 1 0.47 0 0 5.00
13 INT252910 PTTG1 Negative_regulation of Transcription of SLC5A5 1 0.02 0.36 0 5.00
14 INT253011 Negative_regulation of Binding of PTTG1 and Zic2 1 0.01 0.41 0 5.00
15 INT252886 PTTG1IP Positive_regulation of Binding of SLC5A5 and USF1 1 0.00 0.22 0 5.00
16 INT252887 PTTG1IP Positive_regulation of Binding of SLC5A5 and PAX8 1 0.01 0.22 0 5.00
17 INT252898 Binding of SLC5A5 and USF1 1 0.01 0.22 0 5.00
18 INT253021 PTTG1 Regulation of Gene_expression of Fgf2 1 0.04 0.35 0 5.00
19 INT252906 Binding of SLC5A5 and PTTG1 1 0.01 0.69 0 5.00
20 INT253007 Igf1 Regulation of Gene_expression of PTTG1 1 0.03 0.46 0 5.00
21 INT252889 Binding of PTTG2 and PTTG3P 1 0.06 0.08 0 5.00
22 INT253018 Binding of PTTG1 and Zic2 1 0.01 0.76 0 5.00
23 INT252888 Binding of SLC5A5 and PAX8 1 0.02 0.22 0 5.00
24 INT252905 PTTG1IP Negative_regulation of Transcription of SLC5A5 1 0.01 0.35 0 5.00
25 INT253014 Binding of XRCC5 and Zic2 1 0.00 0.14 0 5.00
26 INT253008 PTTG1 Regulation of Gene_expression of Id3 1 0.03 0.2 0 5.00
27 INT252900 PTTG1 Regulation of Gene_expression of TAF9 1 0.20 0.84 0 5.00
28 INT253020 Pttg1 Negative_regulation of THBS1 1 0.03 0.16 0 5.00
29 INT253019 APC Positive_regulation of Protein_catabolism of Pttg1 1 0.06 0 0 5.00
30 INT253012 APC Positive_regulation of Binding of Pttg1 1 0.06 0 0 5.00
31 INT253016 Binding of PTTG1 and Id3 1 0.04 0.07 0 5.00
32 INT252896 INS Regulation of Gene_expression of PTTG1 1 0.00 0.47 0 5.00
33 INT252904 Binding of PRKDC and XRCC5 1 0.00 0.14 0 5.00
34 INT253013 Binding of PRKDC and Zic2 1 0.00 0.14 0 5.00
35 INT252907 Binding of PTTG1 and PTTG2 1 0.07 0.08 0 5.00
36 INT252893 PTTG1 Positive_regulation of Gene_expression of TAF9 1 0.21 0.9 0 5.00
37 INT253005 Binding of Zic2 and Pttg1 1 0.02 0.57 0 5.00
38 INT252903 PTTG1IP Regulation of Gene_expression of SLC5A5 1 0.00 0.43 0 5.00
39 INT252908 Binding of PTTG3P and GOPC 1 0.01 0.08 0 5.00
40 INT252899 PTTG1 Regulation of Gene_expression of SLC5A5 1 0.01 0.43 0 5.00
41 INT253022 PTTG1 Negative_regulation of Negative_regulation of Trp53 1 0.03 1.34 0 5.00
42 INT252890 PTTG1IP Negative_regulation of SLC5A5 1 0.01 0.34 0 5.00
43 INT253006 Anapc1 Positive_regulation of Protein_catabolism of Pttg1 1 0.51 0 0 5.00
44 INT252909 FZR1 Positive_regulation of APC 1 0.06 0.08 0 5.00
45 INT252895 PTTG1 Regulation of Gene_expression of VEGFA 1 0.03 0.15 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Obstructive Uropathy. They are ordered first by their pain relevance and then by number of times they were reported in Obstructive Uropathy. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT118610 Localization of BPHL 6 0.57 6.88 0.33 96.20
2 INT145502 Binding of dds 2 0.39 4.44 0.16 95.84
3 INT1179 Negative_regulation of Ace 157 0.59 67.03 30.46 92.72
4 INT314 Positive_regulation of Ren 212 0.70 66.68 55.56 92.64
5 INT138844 Positive_regulation of CC2D1A 25 0.41 41.36 1.92 91.36
6 INT3971 Positive_regulation of Alb 175 0.70 98.46 36.45 89.72
7 INT615 Regulation of Alb 66 0.62 33.43 15.33 89.36
8 INT252960 Regulation of Regulation of Amhr2 1 0.03 1.35 0 87.52
9 INT252941 Regulation of Amhr2 1 0.08 1.35 0 87.52
10 INT387 Regulation of Ace 18 0.45 5.24 4.24 86.16
11 INT152060 Gene_expression of VUR 75 0.67 83.83 2.34 85.64
12 INT252992 Regulation of Gene_expression of PTTG1 1 0.18 5.07 0.04 85.44
13 INT239093 Gene_expression of PTTG1 84 0.65 83.94 1.87 83.92
14 INT254143 Negative_regulation of CC2D1A 10 0.35 13.81 0.82 77.56
15 INT250743 Localization of CC2D1A 12 0.51 20.97 0.51 77.12
16 INT198606 Localization of CFH 8 0.65 4.37 0.04 76.56
17 INT237382 Localization of VUR 11 0.72 14.58 0.11 76.48
18 INT7205 Positive_regulation of HBG1 65 0.69 40.35 6.37 73.84
19 INT252977 Positive_regulation of PTTG1 1 0.28 8.39 0.18 69.68
20 INT38379 Positive_regulation of VUR 15 0.58 15 0.71 64.08
21 INT252975 Positive_regulation of Gene_expression of PTTG1 36 0.28 31.96 0.74 62.00
22 INT70760 Positive_regulation of Actg2 8 0.48 6.23 0.61 59.68
23 INT105114 Gene_expression of Arigg4 16 0.52 21.88 4.56 58.52
24 INT283232 Negative_regulation of Localization of KCNAB2 1 0.01 0.95 0.26 50.56
25 INT283235 Localization of KCNAB2 1 0.02 0.94 0.26 50.16
26 INT296619 Gene_expression of Pin1 1 0.34 4.07 0.29 48.24
27 INT296620 Negative_regulation of Gene_expression of Pin1 1 0.21 2.82 0.26 48.24
28 INT22939 Gene_expression of Csf2 164 0.78 85.1 32.22 45.44
29 INT5128 Positive_regulation of Lhb 232 0.69 44.23 71.26 39.32
30 INT80222 Negative_regulation of Bcl2 82 0.58 69.16 13.18 36.64
31 INT80220 Positive_regulation of Bcl2 71 0.58 57.73 7.86 36.64
32 INT129454 Negative_regulation of Adamts13 6 0.30 7.78 0.31 36.60
33 INT195758 Negative_regulation of Transcription of Adamts13 1 0.03 2.23 0 36.60
34 INT195759 Transcription of Adamts13 1 0.05 2.22 0 36.20
35 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 35.36
36 INT847 Regulation of Lhb 131 0.61 22.08 46.54 34.08
37 INT171666 Regulation of GOPC 117 0.39 40.41 15.47 34.08
38 INT5129 Regulation of Gene_expression of Lhb 10 0.55 4.79 2.09 34.08
39 INT2261 Gene_expression of Lhb 121 0.77 42.78 26.04 33.52
40 INT97578 Regulation of FSHB 3 0.26 1.41 0.17 29.76
41 INT141542 Negative_regulation of Pin1 2 0.29 10.92 1.1 29.12
42 INT17817 Binding of VUR 41 0.48 46.85 0.95 13.72
43 INT21246 Negative_regulation of ATP1A4 3 0.10 3.3 0.79 13.72
44 INT71602 Negative_regulation of Trp53 84 0.59 67.77 3.68 10.36
45 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
46 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 5.00
47 INT2451 Positive_regulation of Avp 355 0.70 102.66 147.69 5.00
48 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
49 INT85640 Gene_expression of Tg(CAG-EGFP)D4Nagy 1138 0.72 311.58 119.18 5.00
50 INT62124 Gene_expression of NOS1 444 0.78 218.08 114.85 5.00
51 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 5.00
52 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
53 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 5.00
54 INT48406 Gene_expression of Icam1 277 0.78 238.28 81.71 5.00
55 INT1498 Gene_expression of Gh 521 0.75 220.84 81.16 5.00
56 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 5.00
57 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 5.00
58 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 5.00
59 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 5.00
60 INT50957 Negative_regulation of Il6 134 0.59 79.08 42.67 5.00
61 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 5.00
62 INT2429 Negative_regulation of Mpo 128 0.59 93.76 39.57 5.00
63 INT11560 Positive_regulation of CASP3 236 0.70 184.33 39.38 5.00
64 INT14559 Gene_expression of Igf1 254 0.78 112 34.17 5.00
65 INT5117 Negative_regulation of Gene_expression of IL2 118 0.59 52.33 29.96 5.00
66 INT64113 Positive_regulation of Gene_expression of NOS1 110 0.60 71.03 29.72 5.00
67 INT15610 Localization of GOPC 223 0.65 68.26 28.7 5.00
68 INT5206 Gene_expression of AR 316 0.78 113.83 27.29 5.00
69 INT5650 Gene_expression of Mpo 117 0.77 80.27 26.42 5.00
70 INT2614 Gene_expression of CGA 187 0.78 105.89 24.77 5.00
71 INT23937 Gene_expression of EDNRA 103 0.65 55.63 24.67 5.00
72 INT79061 Positive_regulation of NOS2 92 0.65 58.89 23.96 5.00
73 INT34487 Localization of MMP2 56 0.81 31.41 23.61 5.00
74 INT8775 Binding of IGHE 167 0.48 102.61 23.54 5.00
75 INT3330 Gene_expression of AGT 149 0.76 98.65 22.73 5.00
76 INT112029 Positive_regulation of Pik3r1 90 0.67 38.76 20.95 5.00
77 INT93361 Gene_expression of Trp53 208 0.78 175.35 16.65 5.00
78 INT28950 Positive_regulation of Gene_expression of IGF1 99 0.69 46.9 16.47 5.00
79 INT104045 Regulation of Hand1 65 0.35 51.32 16.26 5.00
80 INT85639 Positive_regulation of Tg(CAG-EGFP)D4Nagy 95 0.43 24.83 15.69 5.00
81 INT7970 Gene_expression of PLOD1 120 0.71 44.42 15.54 5.00
82 INT16166 Positive_regulation of DMD 348 0.67 133.22 15.06 5.00
83 INT20665 Gene_expression of ACE 87 0.78 51.71 14.19 5.00
84 INT18012 Gene_expression of EPO 169 0.78 108.36 13.75 5.00
85 INT4145 Gene_expression of FSHR 124 0.77 44.98 13.04 5.00
86 INT31990 Positive_regulation of SOD1 124 0.69 67.79 12.52 5.00
87 INT1735 Gene_expression of HSD11B1 199 0.75 257.87 11.5 5.00
88 INT1734 Negative_regulation of HSD11B1 116 0.57 125.13 10.52 5.00
89 INT79720 Positive_regulation of Cat 57 0.70 31.81 10.11 5.00
90 INT35164 Negative_regulation of IGHE 96 0.58 76.3 9.74 5.00
91 INT20664 Binding of ACE 60 0.48 35.27 9.16 5.00
92 INT92680 Gene_expression of Fgf2 59 0.77 28.11 8.12 5.00
93 INT67037 Gene_expression of Sod1 121 0.78 59.32 7.99 5.00
94 INT53487 Gene_expression of TSC1 81 0.58 77.71 7.94 5.00
95 INT2971 Regulation of IGHE 42 0.61 28.81 7.87 5.00
96 INT10821 Positive_regulation of Abo 32 0.67 9.43 7.65 5.00
97 INT121496 Gene_expression of TERT 107 0.78 45.6 7.42 5.00
98 INT83006 Gene_expression of AGTR1 59 0.75 54.46 7.27 5.00
99 INT103824 Positive_regulation of SOD2 26 0.70 17.42 7.17 5.00
100 INT39282 Negative_regulation of SOD2 27 0.59 16.89 7.03 5.00
101 INT67568 Positive_regulation of Localization of MMP2 14 0.31 8.58 6.79 5.00
102 INT50387 Negative_regulation of AR 67 0.45 26.31 6.61 5.00
103 INT93359 Positive_regulation of Trp53 90 0.70 69.77 6.24 5.00
104 INT16359 Positive_regulation of Gene_expression of AGT 30 0.49 28.27 6.14 5.00
105 INT17913 Regulation of HSD11B1 87 0.60 93.23 6.04 5.00
106 INT64888 Negative_regulation of HBM 52 0.16 34.33 5.45 5.00
107 INT127112 Phosphorylation of Smad2 19 0.80 11.01 5.36 5.00
108 INT60776 Regulation of EDNRA 20 0.51 16.62 5.36 5.00
109 INT92679 Positive_regulation of Fgf2 13 0.69 11.43 5.18 5.00
110 INT57064 Positive_regulation of APC 72 0.66 48.5 5.08 5.00
111 INT37215 Positive_regulation of SMN1 18 0.45 8.99 4.87 5.00
112 INT8340 Negative_regulation of SHBG 49 0.57 35.96 4.73 5.00
113 INT178754 Positive_regulation of Localization of GOPC 32 0.43 10.1 4.73 5.00
114 INT137332 Positive_regulation of Gene_expression of Sod1 41 0.70 19.8 4.69 5.00
115 INT24910 Negative_regulation of Enpp3 20 0.57 8.23 4.67 5.00
116 INT7083 Positive_regulation of HBM 35 0.66 20.96 4.3 5.00
117 INT15724 Negative_regulation of Fn1 15 0.53 5.61 3.87 5.00
118 INT34720 Positive_regulation of SHBG 58 0.69 32.4 3.83 5.00
119 INT26282 Negative_regulation of ELN 9 0.51 6.37 3.76 5.00
120 INT252968 Positive_regulation of TAF9 11 0.45 5.28 3.68 5.00
121 INT16165 Regulation of DMD 114 0.60 35.13 3.64 5.00
122 INT117476 Negative_regulation of Gene_expression of Mpo 10 0.43 8.25 3.33 5.00
123 INT87517 Gene_expression of LDLR 73 0.69 37.35 3.32 5.00
124 INT92814 Negative_regulation of NOS3 25 0.51 20.67 3.07 5.00
125 INT27465 Positive_regulation of F12 21 0.70 8.09 3.06 5.00
126 INT146758 Gene_expression of LCN2 45 0.78 38.29 2.97 5.00
127 INT252999 Gene_expression of TAF9 12 0.75 12.65 2.92 5.00
128 INT137135 Gene_expression of THBS1 28 0.75 11.55 2.45 5.00
129 INT22679 Binding of SERPINE1 25 0.36 17.33 2.36 5.00
130 INT133567 Regulation of IL18 11 0.50 9.54 2.31 5.00
131 INT50558 Negative_regulation of PCNA 31 0.57 13.97 2.3 5.00
132 INT9119 Negative_regulation of TAF9 4 0.42 5.21 2.16 5.00
133 INT87436 Regulation of Fgf2 6 0.45 3.95 2.03 5.00
134 INT60337 Positive_regulation of THBS1 8 0.46 4.69 1.83 5.00
135 INT172961 Localization of Egf 26 0.71 16.74 1.81 5.00
136 INT109967 Gene_expression of Mmv7 21 0.35 15.66 1.7 5.00
137 INT92677 Positive_regulation of Gene_expression of Fgf2 11 0.69 4.25 1.68 5.00
138 INT64233 Regulation of Trp53 35 0.62 27.11 1.53 5.00
139 INT112540 Negative_regulation of Hmgb1 2 0.26 1.98 1.51 5.00
140 INT178615 Binding of SOD2 12 0.48 6.93 1.51 5.00
141 INT262293 Gene_expression of CC2D1A 21 0.40 44.64 1.5 5.00
142 INT182514 Binding of AGTR1 18 0.47 13.35 1.48 5.00
143 INT23938 Positive_regulation of Gene_expression of EDNRA 8 0.45 9.82 1.47 5.00
144 INT189948 Gene_expression of Pttg1 106 0.76 104.68 1.41 5.00
145 INT93357 Regulation of Gene_expression of Trp53 15 0.62 13.4 1.41 5.00
146 INT169907 Gene_expression of Rb1 25 0.60 21.95 1.32 5.00
147 INT147607 Binding of TERT 16 0.48 12.36 1.31 5.00
148 INT138843 Binding of CC2D1A 19 0.33 33.06 1.25 5.00
149 INT174156 Localization of Trp53 16 0.72 13.52 1.18 5.00
150 INT122103 Negative_regulation of Cdh1 5 0.49 2.05 1.18 5.00
151 INT175652 Positive_regulation of BPHL 9 0.44 17.98 1.14 5.00
152 INT103043 Binding of PDE5A 16 0.37 7.79 1.12 5.00
153 INT34586 Positive_regulation of Negative_regulation of HSD11B1 6 0.49 4.39 1.05 5.00
154 INT218696 Negative_regulation of Phosphorylation of Smad2 3 0.42 4.36 0.92 5.00
155 INT297531 Negative_regulation of Ece1 5 0.32 5.49 0.87 5.00
156 INT178498 Negative_regulation of Fgf2 11 0.42 4.21 0.84 5.00
157 INT124850 Gene_expression of Tpt1 42 0.77 14.51 0.79 5.00
158 INT169911 Phosphorylation of Rb1 35 0.73 18.58 0.79 5.00
159 INT189877 Gene_expression of Cdh1 55 0.58 9.36 0.66 5.00
160 INT252993 Negative_regulation of THBS1 8 0.55 6.93 0.59 5.00
161 INT3557 Positive_regulation of C1S 10 0.67 8.73 0.54 5.00
162 INT125821 Regulation of Positive_regulation of IGHE 6 0.40 5.38 0.53 5.00
163 INT154456 Negative_regulation of dds 5 0.37 5.66 0.52 5.00
164 INT176264 Binding of PCNA 21 0.21 9.08 0.51 5.00
165 INT35699 Binding of Umod 3 0.41 2.3 0.46 5.00
166 INT154455 Gene_expression of dds 4 0.58 3.84 0.46 5.00
167 INT70884 Localization of Pdgfb 8 0.35 6.22 0.42 5.00
168 INT283239 Negative_regulation of Localization of CC2D1A 1 0.29 10.4 0.41 5.00
169 INT196916 Negative_regulation of Rb1 13 0.42 14.29 0.4 5.00
170 INT197012 Regulation of Gene_expression of LDLR 4 0.40 1.31 0.4 5.00
171 INT296612 Regulation of Pin1 1 0.23 2.5 0.39 5.00
172 INT189946 Positive_regulation of Gene_expression of Pttg1 14 0.68 23.72 0.38 5.00
173 INT178962 Gene_expression of Oca2 15 0.19 5.15 0.38 5.00
174 INT252989 Localization of PTTG1 1 0.32 1.49 0.36 5.00
175 INT129621 Gene_expression of Id3 5 0.75 2.3 0.36 5.00
176 INT252961 Localization of Fgf1 3 0.27 5.91 0.35 5.00
177 INT101902 Negative_regulation of Mki67 12 0.39 7.92 0.34 5.00
178 INT274379 Negative_regulation of Binding of SERPINE1 1 0.03 0.91 0.33 5.00
179 INT252969 Positive_regulation of Gene_expression of TAF9 5 0.67 5.22 0.32 5.00
180 INT262297 Negative_regulation of Gene_expression of CC2D1A 2 0.25 2.95 0.31 5.00
181 INT141541 Binding of Pin1 2 0.19 1.43 0.27 5.00
182 INT215072 Binding of Camp 6 0.30 2.37 0.26 5.00
183 INT189953 Regulation of PTTG1 2 0.18 6.45 0.25 5.00
184 INT252951 Localization of Oca2 2 0.17 1.53 0.23 5.00
185 INT41984 Regulation of Gene_expression of HSD11B1 4 0.44 4.18 0.23 5.00
186 INT214883 Binding of Atcay 2 0.10 1.1 0.22 5.00
187 INT64674 Regulation of PTTG1IP 3 0.24 0.48 0.21 5.00
188 INT262295 Regulation of CC2D1A 3 0.27 5.38 0.19 5.00
189 INT178884 Positive_regulation of dds 1 0.40 1.76 0.18 5.00
190 INT180525 Regulation of LCN2 4 0.54 4.37 0.18 5.00
191 INT252998 Gene_expression of PTTG1IP 1 0.17 2.06 0.17 5.00
192 INT154134 Regulation of Tymp 4 0.09 1.19 0.17 5.00
193 INT189945 Localization of Pttg1 3 0.73 3.02 0.16 5.00
194 INT283236 Regulation of ATN1 1 0.09 1.67 0.14 5.00
195 INT206133 Binding of CDC42 3 0.25 0.8 0.12 5.00
196 INT168503 Binding of FUS 5 0.29 5.12 0.12 5.00
197 INT10452 Positive_regulation of PTTG1IP 2 0.41 0.6 0.1 5.00
198 INT296610 Negative_regulation of Duox2 1 0.06 2.5 0.09 5.00
199 INT296622 Positive_regulation of Gene_expression of Cdh1 3 0.52 2.24 0.09 5.00
200 INT252971 Positive_regulation of Gene_expression of PTTG1IP 1 0.11 1.37 0.09 5.00
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