D:Ocular Toxicity (including Many Sub-types)

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Disease Term
Synonyms ABERRANT PIGMENTATION, Abnormal Adnexae, Abnormal Anterior Capsule, Abnormal Anterior Cortex, Abnormal Bulbar Conjunctiva, Abnormal Consensual Pupillary Reflex, Abnormal Corneal Reflex, Abnormal Direct Pupillary Reflex, Abnormal Limbus, Abnormal Macula, ABNORMAL MENACE RESPONSE
Documents 2352
Hot Single Events 200
Hot Interactions 24

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Ocular Toxicity (including Many Sub-types). They are ordered first by their relevance to Ocular Toxicity (including Many Sub-types) and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT353109 Binding of VEGFA and Aes 1 0.02 3.93 0.43 100.00
2 INT353105 Binding of Aes and Rgs9bp 1 0.01 0.35 0.05 100.00
3 INT184874 Drd1a Regulation of Gene_expression of Drd2 1 0.13 0.97 0.51 99.68
4 INT131312 Binding of Nts and Datd 1 0.10 0.74 0.46 99.56
5 INT245823 Binding of Plg and Plg 1 0.03 1.41 0 98.96
6 INT245835 Plg Negative_regulation of Gene_expression of VEGFA 1 0.05 3.51 0 98.80
7 INT339587 Positive_regulation of Binding of ABCA1 and RPE 1 0.04 1.38 0.05 97.84
8 INT339583 Binding of ABCA1 and RPE 1 0.03 1.38 0.05 97.48
9 INT270732 DBP Negative_regulation of SHBG 1 0.00 1.08 0 97.40
10 INT165724 Bdkrb1 Positive_regulation of Adora1 1 0.24 1.65 0.43 97.12
11 INT248134 IDS Positive_regulation of CHDH 1 0.08 1.52 0.05 95.80
12 INT37157 Pir Positive_regulation of Kncn 1 0.01 0.38 0.3 92.72
13 INT260496 Hif1a Regulation of Gene_expression of VEGFA 1 0.12 0.93 0 91.24
14 INT245833 Plg Negative_regulation of VEGFA 1 0.05 2.21 0.04 90.24
15 INT245827 Plg Negative_regulation of Vegfa 1 0.14 1.3 0 90.24
16 INT238805 Binding of DSP and HSPB2 1 0.09 4.2 0.13 86.08
17 INT107028 KNG1 Regulation of Des 1 0.01 1.7 0.76 85.04
18 INT339582 AMD1 Regulation of C1QTNF5 1 0.07 2 0 83.84
19 INT152061 Binding of SEPT9 and CD177 1 0.00 1.76 0.31 82.16
20 INT299460 Foxl2 Positive_regulation of Tpr 1 0.01 0.56 0.05 81.60
21 INT299457 Foxl2 Positive_regulation of Gnrhr 1 0.42 0.56 0.05 80.48
22 INT229923 Binding of ABCA1 and C9 1 0.00 0.74 0 80.44
23 INT229981 Binding of ABCA1 and Cdca3 1 0.00 0.74 0 80.44
24 INT308653 Proc Regulation of Gene_expression of Mapk8 1 0.00 1.48 0.36 80.08
25 INT262617 Ager Positive_regulation of Rpe 1 0.00 0.81 0 78.96
26 INT262620 Renbp Positive_regulation of Ager Positive_regulation of Rpe 1 0.00 0.81 0 78.96
27 INT229984 Binding of CD59 and Cdca3 1 0.03 0.73 0 78.40
28 INT229922 Binding of C9 and CD59 1 0.08 0.72 0 78.40
29 INT314756 IL6 Positive_regulation of Gene_expression of Crp 2 0.13 4.58 0.48 77.16
30 INT211492 Positive_regulation of GRIN1 Positive_regulation of Prkca 1 0.01 0.87 0.36 75.76
31 INT340439 Binding of HLA-DMA and SUGT1 1 0.00 4.1 1.16 74.68
32 INT340438 Binding of HLA-DMA and MRAP 1 0.02 1.69 0.43 74.68
33 INT268710 Binding of RHO and ERLEC1 1 0.00 0.71 0.03 74.64
34 INT229983 Binding of CFH and Crp 2 0.14 1.48 0 70.88
35 INT199667 Cep290 Regulation of Atf4 1 0.04 1.96 0.09 69.84
36 INT199666 Cntln Regulation of Atf4 1 0.00 1.95 0.09 69.84
37 INT236079 Binding of AGER and HLA-DQB1 1 0.25 1.06 0 69.84
38 INT236077 Binding of HLA-DQB1 and TNF 1 0.29 1.06 0 69.84
39 INT236076 Binding of HLA-DQB1 and LTA 1 0.25 1.06 0 69.84
40 INT294708 CRP Positive_regulation of Gene_expression of VCAM1 2 0.31 1.92 0.56 63.12
41 INT71329 Cacna1a Regulation of Ea2 1 0.01 0.71 0.15 61.68
42 INT71328 Cacna1a Regulation of Atxn2 1 0.00 0.71 0.15 61.28
43 INT245832 VEGFA Positive_regulation of Phosphorylation of Ocln 1 0.04 1.61 0 60.44
44 INT245830 VEGFA Regulation of Ocln 1 0.02 0.83 0 60.44
45 INT301044 Binding of Csn2 and Trpm1 1 0.09 2.17 0.03 60.08
46 INT353106 Binding of amd and C3 1 0.09 1.69 0 59.20
47 INT245503 SST Regulation of Gene_expression of CSF2 1 0.06 0.67 0.39 58.64
48 INT324926 Ptpro Positive_regulation of Bdkrb2 1 0.01 2.25 1.5 57.96
49 INT172838 Binding of ISL1 and T2dm2 1 0.00 2.41 0 56.80
50 INT233929 PPARA Negative_regulation of ras 1 0.02 2.39 0.22 56.04
51 INT242858 Binding of HFE and INS 1 0.06 1.64 0 55.84
52 INT233397 Binding of ABCA4 and COL2A1 1 0.38 3.59 0.03 55.68
53 INT245821 Binding of Ppp2r2b and Ocln 1 0.00 0.81 0 55.48
54 INT242618 Binding of Slc18a3 and Th 1 0.13 0.26 0.05 53.04
55 INT324927 Syt17 Positive_regulation of Bdkrb1 1 0.04 4.29 2.96 51.76
56 INT260821 NRP2 Positive_regulation of Gene_expression of TNF 1 0.01 1.48 0.56 51.52
57 INT260830 Binding of NRP2 and Flt1 Positive_regulation of Gene_expression of TNF 1 0.01 1.5 0.56 51.52
58 INT260845 Binding of Flt1 and Positive_regulation of Gene_expression of TNF 1 0.36 1.5 0.56 51.52
59 INT172206 Binding of Slc6a3 and ADHD1 2 0.03 2.76 1.61 50.96
60 INT184877 Negative_regulation of Binding of Slc6a3 and ADHD1 1 0.01 0.69 0.45 50.96
61 INT339580 TIMP3 Positive_regulation of ABCA1 1 0.16 0.73 0 50.00
62 INT339586 TIMP3 Positive_regulation of RPE 1 0.16 0.72 0 50.00
63 INT256104 Binding of Serpina3k and Positive_regulation of Positive_regulation of Hspg2 1 0.03 1 0 49.36
64 INT245831 Phosphorylation of Mapk3 Positive_regulation of Gene_expression of VEGFA 1 0.05 0.58 0 46.84
65 INT260833 Binding of NRP2 and Flt1 1 0.00 3.61 1.22 45.92
66 INT174104 Binding of HSPG2 and Ache 1 0.16 0.98 0.09 43.84
67 INT317900 Binding of NCAPH2 and MCPH1 1 0.02 0.53 0 43.84
68 INT194595 Binding of TNFSF10 and TNFRSF10B 4 0.15 9.3 0.53 42.76
69 INT194596 Binding of HLA-DRB4 and TNFSF10 3 0.08 6 0.38 42.76
70 INT339581 Binding of TIMP1 and TIMP3 1 0.30 0.54 0 42.40
71 INT245820 Binding of Sp1 and Tfap2a 1 0.03 0.64 0 41.92
72 INT245829 Binding of VEGFA and Sp1 1 0.04 0.65 0 41.92
73 INT245828 Binding of VEGFA and Tfap2a 1 0.01 0.64 0 41.72
74 INT245822 Plg Negative_regulation of Phosphorylation of Mapk3 1 0.10 2.09 0 38.24
75 INT262619 Gopc Regulation of Gene_expression of ROS1 1 0.01 0.51 0 37.76
76 INT236078 Binding of AGER and HLA-DMA 1 0.08 0.81 0 34.72
77 INT339585 Binding of AMD1 and MDM1 1 0.06 2.02 0 34.56
78 INT256072 Serpina3k Negative_regulation of Positive_regulation of Ros1 1 0.04 0.49 0 33.28
79 INT316217 BDKRB1 Positive_regulation of BDKRB2 1 0.09 0.71 0.03 27.16
80 INT316218 GOPC Positive_regulation of BDKRB2 1 0.08 0.71 0.03 27.16
81 INT229977 Binding of amd and Cfb 1 0.03 2.78 0.06 26.76
82 INT229985 Binding of C2 and amd 1 0.01 1.89 0.06 25.04
83 INT239407 Binding of MTTP and PADI1 1 0.23 0.5 0 23.52
84 INT239408 Binding of PADI1 and TAOK1 1 0.01 0.51 0 23.52
85 INT260842 Binding of NRP2 and Kdr 1 0.00 2.28 0.85 23.28
86 INT207776 Binding of FKBP1A and RYR1 1 0.05 0.59 0.12 21.04
87 INT230760 VEGFA Positive_regulation of Flt1 1 0.03 0.96 0.12 19.80
88 INT230761 VEGFA Positive_regulation of Kdr 2 0.02 2.16 0.12 19.80
89 INT239406 Binding of MTTP and TAOK1 1 0.02 0.51 0 16.96
90 INT175911 Binding of SERPINE1 and CNBP 1 0.01 1.02 0.22 14.52
91 INT233904 NLRP3 Positive_regulation of AGT 1 0.06 0.81 0.17 13.88
92 INT299438 Foxl2 Negative_regulation of Star 1 0.37 0.16 0 12.64
93 INT175910 SERPINE1 Negative_regulation of PLAU 1 0.06 1.01 0.22 12.56
94 INT292621 Binding of IL6 and Gpt 1 0.01 3.88 0.24 10.00
95 INT256228 EDNRB Positive_regulation of EDN1 1 0.26 0.62 0.03 9.12
96 INT273136 Binding of CHED1 and VSX1 1 0.15 0.12 0 6.56
97 INT77646 Binding of Ngf and Ntrk1 23 0.40 7.85 9.26 5.00
98 INT106559 Binding of Bdnf and Ntrk2 23 0.43 11.09 7.33 5.00
99 INT88279 Ngf Positive_regulation of Ntrk1 5 0.76 3.06 5.23 5.00
100 INT64718 IL1B Positive_regulation of Gene_expression of IL6 15 0.59 9.37 4.48 5.00
101 INT64719 IL1B Positive_regulation of IL6 7 0.41 6.84 3.14 5.00
102 INT106560 Binding of Ntf3 and Ntrk2 3 0.14 2.47 2.84 5.00
103 INT208991 Binding of CALM1 and Ca2 10 0.06 1.34 1.55 5.00
104 INT256299 Binding of Efnb1 and Ephb1 1 0.02 1.22 1.42 5.00
105 INT172834 Binding of IL6 and T2dm2 1 0.00 6.4 1.4 5.00
106 INT242605 Gdnf Positive_regulation of Trpv1 1 0.26 0.17 1.3 5.00
107 INT242623 Binding of Ntf3 and Ntrk3 5 0.22 1.31 1.29 5.00
108 INT184919 Binding of da and Slc6a3 1 0.12 0.33 1.23 5.00
109 INT256298 Binding of Creb1 and Ephb1 1 0.16 1.27 1.22 5.00
110 INT194861 Binding of IL1B and IL1R1 2 0.01 1.55 1.2 5.00
111 INT256297 Binding of Creb1 and Insrr 1 0.00 1.22 1.19 5.00
112 INT256295 Binding of Creb1 and Grin2b 1 0.11 1.21 1.19 5.00
113 INT289465 IRF6 Positive_regulation of IL1B 3 0.05 0.9 1.16 5.00
114 INT242625 Gdnf Positive_regulation of Pax3 1 0.01 0.34 1.15 5.00
115 INT242624 Binding of Ngf and Ntrk2 5 0.24 0.48 1.11 5.00
116 INT173059 Binding of KDR and VEGFA 43 0.43 29.63 1.1 5.00
117 INT256294 Binding of Grin2b and Ephb1 1 0.28 1.11 1.08 5.00
118 INT256293 Binding of Grin2b and Insrr 1 0.01 1.06 1.05 5.00
119 INT225158 Binding of CDK2 and CDKN1A 7 0.30 3.26 1.02 5.00
120 INT242642 Binding of BDNF and Ngfr 2 0.21 1.38 1.01 5.00
121 INT81127 Binding of Gabrd and Abat 3 0.25 0 0.96 5.00
122 INT285418 IRF6 Positive_regulation of Localization of IL6 3 0.05 0.66 0.93 5.00
123 INT219154 Binding of HMGB1 and TLR4 2 0.17 4.45 0.93 5.00
124 INT289461 IRF6 Positive_regulation of ICAM1 1 0.08 0.61 0.91 5.00
125 INT242621 Gdnf Positive_regulation of Gene_expression of Scn11a 1 0.05 0.12 0.88 5.00
126 INT184916 Binding of da and Th 1 0.09 1.22 0.87 5.00
127 INT340437 Binding of SERPINH1 and HLA-DRB4 1 0.00 2.26 0.84 5.00
128 INT257895 Positive_regulation of Sostdc1 Positive_regulation of Positive_regulation of GRIN1 1 0.00 0.09 0.83 5.00
129 INT257896 Sostdc1 Positive_regulation of Positive_regulation of GRIN1 1 0.00 0.09 0.83 5.00
130 INT189671 DAG1 Positive_regulation of PRKCA 3 0.12 0.71 0.82 5.00
131 INT184918 da Positive_regulation of Negative_regulation of Th 1 0.14 0.14 0.77 5.00
132 INT242626 Binding of Ngf and Ntrk3 3 0.15 0.27 0.77 5.00
133 INT111080 Binding of CA1 and CA2 2 0.02 1.62 0.73 5.00
134 INT260832 Binding of NRP2 and Nrp1 1 0.00 2.32 0.7 5.00
135 INT334395 IL1B Positive_regulation of Tnf 1 0.11 2.83 0.69 5.00
136 INT165583 Binding of Bdnf and Ngf 3 0.33 0.81 0.69 5.00
137 INT308668 Akt1 Positive_regulation of Nos3 3 0.05 4.61 0.65 5.00
138 INT242635 Binding of Bdnf and Ntrk3 3 0.25 0.98 0.64 5.00
139 INT172825 Binding of Crp and T2dm2 1 0.00 4.5 0.62 5.00
140 INT255690 Binding of VEGFA and Flt1 8 0.34 3.44 0.61 5.00
141 INT324925 Ros1 Positive_regulation of Bdkrb1 1 0.08 0.67 0.6 5.00
142 INT242584 Gdnf Regulation of Gene_expression of Qrfp 1 0.00 0.09 0.58 5.00
143 INT242602 Binding of Ntf3 and Ntrk1 1 0.10 0.14 0.57 5.00
144 INT144035 IL6 Positive_regulation of STAT3 4 0.31 2.58 0.56 5.00
145 INT256296 Efnb1 Positive_regulation of Ephb1 1 0.03 0.66 0.54 5.00
146 INT184878 Binding of Lmo1 and ADHD1 2 0.04 2.33 0.53 5.00
147 INT242613 Binding of Gfra2 and Ret 1 0.02 0 0.52 5.00
148 INT242631 Binding of Gfra2 and Ntrk1 1 0.01 0 0.52 5.00
149 INT184922 Negative_regulation of Th Negative_regulation of da 1 0.12 0.18 0.52 5.00
150 INT242614 Binding of Gdnf and Gfra1 1 0.03 0 0.51 5.00
151 INT248135 Binding of IDS and ACCS 1 0.09 1.12 0.51 5.00
152 INT242598 Binding of Gdnf and Gfra2 4 0.16 0.38 0.51 5.00
153 INT308656 Pik3r1 Positive_regulation of Nos3 1 0.02 1.8 0.5 5.00
154 INT242597 Gene_expression of Gdnf Negative_regulation of Trpv1 1 0.27 0.08 0.5 5.00
155 INT289464 Negative_regulation of IRF6 Positive_regulation of ICAM1 1 0.07 0.31 0.5 5.00
156 INT242638 Binding of BDNF and Gdnf 1 0.29 0 0.49 5.00
157 INT242600 Binding of Gdnf and Gopc 1 0.06 0 0.49 5.00
158 INT300956 Il4 Negative_regulation of IL8 1 0.02 0.37 0.48 5.00
159 INT260836 Il18 Positive_regulation of Localization of VEGFA 1 0.06 1.67 0.48 5.00
160 INT242604 Gdnf Regulation of Gene_expression of Trpv1 1 0.17 0.36 0.48 5.00
161 INT289462 Negative_regulation of IRF6 Positive_regulation of IL1B 2 0.04 0.31 0.48 5.00
162 INT300960 Il4 Negative_regulation of IL1B 1 0.03 0.37 0.48 5.00
163 INT289463 IRF6 Positive_regulation of Localization of IL1B 1 0.05 0.52 0.48 5.00
164 INT300957 Binding of IL13 and Il4 1 0.01 0.58 0.48 5.00
165 INT300959 Il4 Negative_regulation of TNF 1 0.03 0.37 0.48 5.00
166 INT300955 Il4 Negative_regulation of Il6 1 0.03 0.37 0.48 5.00
167 INT340440 Binding of HLA-B and BTG3 1 0.05 1.57 0.47 5.00
168 INT260843 Il6 Positive_regulation of Localization of VEGFA 1 0.06 1.67 0.47 5.00
169 INT260838 Il17a Positive_regulation of Localization of VEGFA 1 0.06 1.67 0.47 5.00
170 INT260839 Hivep3 Positive_regulation of Gene_expression of TNF 1 0.01 1.21 0.47 5.00
171 INT197496 Binding of Apoe and Lrp1 4 0.22 2.32 0.46 5.00
172 INT242628 Binding of Gfra1 and Ret 1 0.03 0 0.46 5.00
173 INT242634 Binding of Gfra1 and Ntrk1 1 0.02 0 0.46 5.00
174 INT242615 Ret Positive_regulation of Gene_expression of Gfra1 1 0.04 0 0.46 5.00
175 INT242596 Binding of Ntrk1 and Ret 1 0.12 0 0.46 5.00
176 INT114341 Agt Positive_regulation of AGT 3 0.01 1.15 0.43 5.00
177 INT285725 Binding of IGF1R and INS 1 0.27 0.07 0.4 5.00
178 INT191493 Binding of AGTR1 and NLRP3 2 0.03 2.35 0.39 5.00
179 INT242607 Negative_regulation of Ntrk1 Positive_regulation of Ret 1 0.16 0 0.39 5.00
180 INT230724 EDN1 Positive_regulation of EDNRA 3 0.24 4.12 0.39 5.00
181 INT331966 Binding of DES and SACM1L 1 0.01 1.86 0.36 5.00
182 INT334393 IL6 Positive_regulation of Tnf 1 0.16 1.41 0.35 5.00
183 INT242616 Gfra1 Regulation of Gene_expression of Gfra2 1 0.00 0 0.34 5.00
184 INT230786 Binding of AGT and ACE 4 0.15 2.53 0.34 5.00
185 INT89381 INS Positive_regulation of AKT1 6 0.43 3.06 0.33 5.00
186 INT230855 KNG1 Regulation of NOS1 2 0.03 0.94 0.33 5.00
187 INT230852 ACE Regulation of KNG1 2 0.03 0.72 0.32 5.00
188 INT308667 Binding of Chrm1 and Positive_regulation of Binding of App 1 0.04 1.14 0.32 5.00
189 INT255740 Pik3r1 Positive_regulation of Akt1 5 0.24 2.42 0.31 5.00
190 INT72445 Binding of AGT and REN 3 0.34 0.88 0.31 5.00
191 INT172822 Binding of Fga and T2dm2 1 0.01 2.24 0.31 5.00
192 INT188789 Binding of pad and Mthfr 1 0.06 4.6 0.31 5.00
193 INT242622 Binding of Bdnf and Ntrk1 1 0.05 0.07 0.29 5.00
194 INT260841 Il6 Positive_regulation of Localization of NRP2 1 0.00 0.7 0.29 5.00
195 INT260831 Pgf Positive_regulation of TNF 1 0.60 0.75 0.29 5.00
196 INT182499 Binding of AGTR1 and AGTR2 3 0.20 2.79 0.28 5.00
197 INT260828 Pgf Positive_regulation of Gene_expression of Gtf3a 1 0.01 0.73 0.28 5.00
198 INT260837 NRP2 Negative_regulation of Negative_regulation of Bcl2 1 0.00 0.9 0.28 5.00
199 INT344402 Binding of Crp and Spp1 1 0.05 2.92 0.28 5.00
200 INT351391 Binding of Sod2 and Gtf3a 1 0.00 0.18 0.27 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Ocular Toxicity (including Many Sub-types). They are ordered first by their pain relevance and then by number of times they were reported in Ocular Toxicity (including Many Sub-types). Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT268715 Binding of RPE 3 0.09 2.36 0.09 100.00
2 INT63183 Negative_regulation of Kpnb1 2 0.37 8.26 0.08 100.00
3 INT299420 Negative_regulation of Gene_expression of Star 1 0.33 6.66 0.5 100.00
4 INT167716 Negative_regulation of Gene_expression of Gnrhr 2 0.35 6.64 0.93 100.00
5 INT174987 Binding of AIRN 12 0.32 6.79 1.21 100.00
6 INT285294 Localization of RCVRN 1 0.01 2.56 0 100.00
7 INT113865 Binding of CXADR 35 0.46 3.18 1.12 100.00
8 INT174986 Gene_expression of AIRN 20 0.57 6.13 0.64 100.00
9 INT239497 Binding of Aes 8 0.29 3.61 0.84 100.00
10 INT40698 Positive_regulation of Aes 3 0.32 3.84 0.65 100.00
11 INT177328 Positive_regulation of CXADR 9 0.48 4.29 2.27 100.00
12 INT239498 Localization of Aes 2 0.58 2.22 0.4 100.00
13 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 100.00
14 INT34263 Positive_regulation of Mastl 8 0.35 1.36 4.35 100.00
15 INT38056 Localization of Crp 71 0.78 53.14 17.03 100.00
16 INT55367 Localization of Dbp 18 0.70 7.43 0.38 100.00
17 INT1837 Gene_expression of Olfr1284 1 0.67 0.4 0.04 99.96
18 INT273144 Binding of CHED1 1 0.19 1.7 0 99.92
19 INT2758 Binding of Dbp 36 0.44 8.3 14.47 99.86
20 INT16782 Binding of ERLEC1 15 0.10 8.23 1.7 99.84
21 INT3971 Positive_regulation of Alb 175 0.70 98.46 36.45 99.84
22 INT228771 Localization of C3ar1 2 0.03 2.71 0.38 99.84
23 INT18773 Localization of ALB 117 0.80 69.18 13.8 99.78
24 INT4679 Negative_regulation of RAPGEF5 55 0.57 47.51 4.55 99.78
25 INT75063 Regulation of Gene_expression of Drd2 10 0.62 2.82 7.38 99.68
26 INT54565 Binding of SCLC1 12 0.31 20.41 0.81 99.62
27 INT122976 Binding of Datd 7 0.33 3.99 2.59 99.56
28 INT170332 Gene_expression of IFN1@ 477 0.75 275.21 69.65 99.56
29 INT18121 Binding of Maoa 20 0.48 2.4 9.3 99.56
30 INT2774 Binding of Crp 241 0.48 195.89 44.39 99.54
31 INT78317 Regulation of CACNA1A 8 0.62 7.68 3.08 99.52
32 INT505 Positive_regulation of GPT 89 0.67 69.38 14.94 99.52
33 INT36700 Negative_regulation of CEACAM4 2 0.48 1.65 0.58 99.50
34 INT161960 Regulation of lg 5 0.26 1.18 2.84 99.46
35 INT70987 Binding of RAC1 14 0.37 12.14 2.13 99.44
36 INT16455 Gene_expression of Drd2 116 0.78 22.71 38.47 99.44
37 INT175904 Localization of RAC1 7 0.41 5.05 0.86 99.44
38 INT102901 Regulation of Gene_expression of Th 12 0.60 2.42 3.22 99.44
39 INT30817 Gene_expression of Th 142 0.76 33.56 38.12 99.44
40 INT57039 Positive_regulation of Gene_expression of Drd2 16 0.50 1.98 9.48 99.44
41 INT10874 Negative_regulation of Twist1 89 0.50 36.84 11.32 99.32
42 INT79395 Gene_expression of Twist1 193 0.77 100.06 26.34 99.26
43 INT216512 Gene_expression of C3AR1 13 0.70 8.44 1.31 99.24
44 INT39712 Binding of pad 82 0.48 110.92 10.33 99.20
45 INT51779 Gene_expression of Drd1a 46 0.66 11.18 17.51 99.16
46 INT138694 Negative_regulation of NINL 1 0.38 0.97 0.48 99.14
47 INT326 Gene_expression of Gnrhr 105 0.76 35.87 34.93 99.12
48 INT144198 Positive_regulation of HSPB2 7 0.48 5.66 0.11 99.08
49 INT42942 Gene_expression of Clstn2 3 0.67 1.05 0.31 99.08
50 INT78316 Regulation of TGM6 3 0.16 3.09 0.95 99.04
51 INT37103 Gene_expression of CHRNE 5 0.67 4.32 0.12 99.04
52 INT220700 Gene_expression of MUSK 3 0.75 6.67 0.07 99.04
53 INT299416 Gene_expression of Star 1 0.53 1.72 0.1 99.00
54 INT1533 Negative_regulation of AGT 105 0.42 46.54 16.92 99.00
55 INT7527 Gene_expression of SLTM 12 0.25 2.9 6.07 98.96
56 INT3777 Positive_regulation of NARFL 256 0.56 302.43 25.74 98.90
57 INT8048 Gene_expression of Nts 45 0.74 8.9 21.84 98.90
58 INT109925 Gene_expression of RPE 11 0.65 12.46 0.68 98.84
59 INT144322 Regulation of RPE 1 0.24 1.9 0.08 98.82
60 INT21546 Regulation of ABCA1 16 0.40 4.21 1.04 98.82
61 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 98.80
62 INT124218 Gene_expression of Pon1 9 0.75 19.55 1.19 98.80
63 INT16150 Positive_regulation of NKG7 10 0.69 10.26 1.73 98.80
64 INT14503 Binding of BCHE 13 0.48 3.95 1.85 98.76
65 INT131311 Negative_regulation of Pitx3 1 0.56 0.5 0.34 98.72
66 INT78659 Gene_expression of Thim 17 0.28 14.34 4.4 98.68
67 INT261192 Gene_expression of Niacr1 57 0.67 24.37 1.89 98.62
68 INT1218 Negative_regulation of Maob 24 0.59 9.76 9.39 98.62
69 INT48692 Binding of VEGFA 345 0.48 210.3 21.31 98.60
70 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 98.60
71 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 98.60
72 INT3952 Negative_regulation of ALB 116 0.59 72.18 18.35 98.56
73 INT272511 Positive_regulation of DMPK 8 0.54 6.85 0.72 98.52
74 INT6302 Binding of IFNA1 196 0.48 133.85 32.73 98.50
75 INT240765 Positive_regulation of Pon1 16 0.67 12.06 0.48 98.48
76 INT229940 Positive_regulation of amd 10 0.49 27.97 0.15 98.40
77 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 98.40
78 INT20665 Gene_expression of ACE 87 0.78 51.71 14.19 98.40
79 INT152062 Gene_expression of Foxl2 1 0.02 1.54 0.17 98.36
80 INT504 Gene_expression of GPT 42 0.75 27.54 3.99 98.32
81 INT139863 Binding of amd 27 0.41 41.3 0.91 98.28
82 INT200491 Gene_expression of Eng 1 0.13 0.79 0.16 98.28
83 INT124297 Gene_expression of Sod2 112 0.77 65.65 7.64 98.24
84 INT141658 Positive_regulation of Gene_expression of Sod2 51 0.69 35.6 3.71 98.24
85 INT128054 Gene_expression of Per1 15 0.61 2.12 11.84 98.20
86 INT1982 Regulation of NARFL 119 0.49 116.2 14.35 98.20
87 INT36453 Binding of ABCA1 48 0.45 19.9 10.84 98.18
88 INT112704 Positive_regulation of Hif1a 25 0.67 21.49 4.23 98.16
89 INT3040 Gene_expression of MIA3 81 0.24 53.61 12.62 98.08
90 INT121954 Binding of Mthfr 17 0.44 13.47 4.66 98.08
91 INT175214 Gene_expression of HSPB2 21 0.72 22.84 0.81 98.04
92 INT28834 Positive_regulation of Bdkrb1 38 0.69 30.48 26.89 98.04
93 INT255233 Negative_regulation of MCDR1 1 0.07 2.07 0 98.00
94 INT130149 Binding of Bre 3 0.26 0.64 0.19 98.00
95 INT296002 Negative_regulation of Egln3 1 0.56 4.48 0 97.96
96 INT22380 Binding of Hba-a1 1 0.42 0.84 0.09 97.96
97 INT118755 Gene_expression of Per2 12 0.68 2.81 11.41 97.80
98 INT66331 Gene_expression of Cacna1a 101 0.78 49.58 46.32 97.72
99 INT146355 Negative_regulation of Aes 15 0.51 7.83 4.25 97.72
100 INT68299 Binding of Tnf 17 0.39 12.55 7.49 97.72
101 INT161220 Binding of Ccl2 17 0.46 17.63 4.94 97.72
102 INT224722 Binding of Mcpt1 6 0.10 4.82 1.03 97.72
103 INT23045 Positive_regulation of Hbb 31 0.64 19.35 4.54 97.72
104 INT100458 Positive_regulation of LTA 11 0.49 6.55 0.8 97.64
105 INT190472 Regulation of PRDX5 1 0.44 0.69 0 97.60
106 INT20003 Gene_expression of Scn2a1 125 0.71 8.78 23.94 97.56
107 INT177341 Negative_regulation of HMHB1 21 0.03 12.48 1.25 97.48
108 INT29094 Binding of C3 39 0.37 12.65 2.27 97.48
109 INT86024 Gene_expression of PPARA 736 0.78 497.93 91.14 97.44
110 INT93350 Binding of Lepr 17 0.05 27.21 1.5 97.36
111 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 97.32
112 INT95755 Negative_regulation of Acox1 3 0.03 1.9 0.27 97.24
113 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7 97.20
114 INT167717 Gene_expression of Gnrhr 5 0.55 2.49 0.69 97.16
115 INT16772 Gene_expression of MPO 81 0.78 90.98 11.9 97.12
116 INT78827 Gene_expression of Bdkrb1 34 0.78 18.48 15.81 97.12
117 INT113039 Binding of Bdkrb1 9 0.48 5.71 4.51 97.12
118 INT74164 Negative_regulation of UBXN11 14 0.42 6.76 1.4 97.04
119 INT1166 Negative_regulation of Dbh 56 0.59 12.54 28.26 97.00
120 INT11823 Positive_regulation of GGT1 53 0.67 45.84 7.55 96.96
121 INT25271 Positive_regulation of MTG1 21 0.67 13.59 5.96 96.88
122 INT107386 Negative_regulation of AGTR1 37 0.55 35.94 5.15 96.72
123 INT1981 Negative_regulation of NARFL 219 0.47 223.48 16.41 96.64
124 INT144205 Regulation of HSPB2 2 0.43 1.74 0 96.56
125 INT37151 Localization of Th 13 0.57 3.11 4.82 96.52
126 INT163461 Regulation of ABL1 8 0.32 5.98 0.14 96.40
127 INT251238 Gene_expression of Lvs 35 0.32 29.41 1.59 96.40
128 INT7474 Gene_expression of Man2a2 38 0.67 3.31 18.42 96.28
129 INT97374 Gene_expression of Egln3 2 0.75 10.27 0.75 96.24
130 INT296004 Positive_regulation of Gene_expression of Egln3 1 0.67 3.36 0 96.24
131 INT130700 Gene_expression of HSPA5 16 0.75 11.55 2.81 96.24
132 INT222650 Gene_expression of Col4a2 6 0.19 1.84 0.19 96.24
133 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 96.20
134 INT74631 Gene_expression of UBXN11 19 0.75 6.11 0.57 96.20
135 INT134756 Positive_regulation of Gene_expression of Hif1a 8 0.50 11.14 2.68 96.20
136 INT47459 Gene_expression of Rac1 101 0.68 45.27 24.33 96.20
137 INT40160 Positive_regulation of Adora1 74 0.70 26.36 33.03 96.16
138 INT19155 Binding of Adora1 25 0.47 6.41 10.72 96.16
139 INT114406 Gene_expression of Adora1 28 0.72 6.83 9.13 96.16
140 INT44757 Gene_expression of PRCP 3 0.53 1.39 0.82 96.12
141 INT155838 Binding of GGT1 7 0.47 13.27 1.11 95.96
142 INT242530 Regulation of Kpnb1 1 0.05 2.16 0 95.92
143 INT15557 Regulation of Localization of Alb 13 0.50 5.71 2.91 95.84
144 INT112713 Gene_expression of Hif1a 24 0.75 20.48 5.45 95.80
145 INT123466 Binding of T2dm2 21 0.37 34.87 2.91 95.80
146 INT252 Localization of GH1 529 0.80 227.4 122.05 95.68
147 INT9649 Positive_regulation of LPA 105 0.69 74.75 13.89 95.68
148 INT61753 Binding of HBN1 13 0.09 21.66 1.38 95.64
149 INT15723 Gene_expression of Fn1 47 0.78 37.59 8.51 95.60
150 INT184841 Localization of Snap25 12 0.81 1.45 1.09 95.56
151 INT69486 Negative_regulation of Bcl2a1c 34 0.10 19.03 0.6 95.52
152 INT22369 Negative_regulation of Drd1a 15 0.47 6.13 6.87 95.52
153 INT4873 Positive_regulation of FCGR3A 21 0.49 14.35 2.89 95.48
154 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 95.44
155 INT57274 Positive_regulation of Gene_expression of COL7A1 50 0.69 24.19 4.72 95.44
156 INT425 Localization of PRL 455 0.81 189.64 144.8 95.40
157 INT182676 Transcription of C4B 1 0.31 4.82 3.66 95.36
158 INT39144 Gene_expression of RIPK2 5 0.75 2.56 1.27 95.36
159 INT39145 Gene_expression of CER1 1 0.72 0.37 0.22 95.36
160 INT14436 Gene_expression of Dbh 42 0.72 9.9 19.85 95.32
161 INT97777 Positive_regulation of CNBP 7 0.37 9.85 1.09 95.28
162 INT191926 Negative_regulation of Lepr 13 0.48 17.68 0.8 95.24
163 INT269746 Positive_regulation of Localization of AMD1 1 0.43 2.54 0 95.20
164 INT163134 Gene_expression of ACR 78 0.65 30.39 38.48 95.20
165 INT26729 Negative_regulation of Drd2 28 0.55 9.32 15.17 95.16
166 INT7678 Localization of Alb 142 0.81 80.93 22.49 95.12
167 INT13383 Negative_regulation of GCC1 1 0.01 0.39 0.22 95.12
168 INT4345 Gene_expression of Gtf3a 157 0.67 80.75 48.47 95.08
169 INT134753 Gene_expression of TIMP3 19 0.68 15.24 0.88 94.92
170 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 94.88
171 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 94.88
172 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 94.88
173 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 94.88
174 INT69786 Positive_regulation of Gene_expression of MYOC 4 0.50 1.36 0.55 94.88
175 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 94.88
176 INT262589 Gene_expression of Gfi1b 1 0.01 0.57 0 94.80
177 INT17980 Positive_regulation of Egln3 2 0.58 2.52 0.07 94.72
178 INT8629 Positive_regulation of COL7A1 72 0.69 40.66 12.09 94.72
179 INT228770 Gene_expression of amd 16 0.57 21.49 1.05 94.64
180 INT443 Localization of POMC 1020 0.81 284.52 443.17 94.64
181 INT6128 Positive_regulation of Localization of POMC 256 0.70 68.77 121.64 94.64
182 INT1756 Negative_regulation of DNAH8 105 0.59 42.73 20.24 94.64
183 INT69782 Gene_expression of MYOC 12 0.78 8.44 0.61 94.52
184 INT113850 Negative_regulation of Cdkn1b 4 0.42 3.45 0.6 94.48
185 INT272273 Gene_expression of NARFL 89 0.54 121.19 4.47 94.44
186 INT16996 Gene_expression of PRTN3 113 0.75 85.61 22.57 94.44
187 INT17035 Positive_regulation of TFPI 55 0.61 34.88 14.18 94.44
188 INT272272 Positive_regulation of Gene_expression of NARFL 17 0.40 18.85 0.31 94.44
189 INT131308 Gene_expression of Pitx3 11 0.74 3.69 3.5 94.40
190 INT34465 Regulation of Oprd1 34 0.45 7.14 34.29 94.36
191 INT30031 Gene_expression of Hba-a1 7 0.60 7.46 4.41 94.20
192 INT269750 Localization of AMD1 2 0.64 2.82 0.13 94.16
193 INT239412 Binding of ABL1 8 0.28 5.39 0.18 94.08
194 INT135337 Gene_expression of PTPRN2 2 0.72 0.82 0 94.04
195 INT236082 Positive_regulation of Localization of LTA 1 0.49 1.47 0 93.88
196 INT8210 Positive_regulation of Gene_expression of INS 188 0.68 146.57 12.83 93.88
197 INT17938 Binding of Cpe 28 0.48 11.17 13.62 93.80
198 INT26408 Negative_regulation of da 36 0.18 13.46 20.32 93.76
199 INT70916 Binding of Thim 13 0.02 8.35 1.72 93.76
200 INT15921 Positive_regulation of Serpine1 85 0.68 81.24 13.4 93.72
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