D:Open-angle Glaucoma

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Disease Term
Synonyms Compensated Glaucoma, Compensated Glaucomas, Compensative Glaucoma, Compensative Glaucomas, Glaucoma Compensated, Glaucoma Compensative, Glaucoma Open Angle, GLAUCOMA PIGMENTARY, Glaucoma Simple, Glaucoma Simplex, Glaucomas Compensated
Documents 55
Hot Single Events 30
Hot Interactions 3

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Open-angle Glaucoma. They are ordered first by their relevance to Open-angle Glaucoma and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT267116 Binding of Lmx1b and Nps 1 0.30 1.95 0 98.44
2 INT267115 Lmx1b Regulation of Gene_expression of Col4a1 1 0.09 1.37 0 92.08
3 INT267117 Lmx1b Regulation of Col7a1 1 0.02 1.29 0 83.04
4 INT267119 Lmx1b Regulation of Regulation of Col4a1 1 0.09 0.67 0 51.60
5 INT267118 Lmx1b Regulation of Regulation of Col7a1 1 0.06 0.47 0 46.40
6 INT111080 Binding of CA1 and CA2 2 0.02 1.62 0.73 5.00
7 INT289998 CNTF Negative_regulation of Casp3 1 0.04 0.99 0.22 5.00
8 INT289981 Cntf Negative_regulation of Casp3 1 0.02 1.01 0.22 5.00
9 INT289997 CNTF Negative_regulation of Binding of CNTF and Casp3 1 0.05 0.99 0.22 5.00
10 INT289999 Binding of CNTF and Casp3 1 0.04 0.99 0.22 5.00
11 INT247851 Negative_regulation of Aqp4 Negative_regulation of Positive_regulation of Narfl 1 0.09 1.78 0.15 5.00
12 INT247843 Narfl Regulation of Aqp4 1 0.04 1.07 0.04 5.00
13 INT247855 Positive_regulation of Narfl Regulation of Aqp4 1 0.04 2.93 0.04 5.00
14 INT247856 Narfl Negative_regulation of Gene_expression of Uchl1 1 0.03 1 0.03 5.00
15 INT272528 THBS1 Positive_regulation of TGFB2 1 0.09 0.64 0.03 5.00
16 INT247847 Narfl Positive_regulation of Positive_regulation of Casp3 1 0.02 0.79 0 5.00
17 INT247853 Positive_regulation of Narfl Negative_regulation of Gene_expression of Uchl1 1 0.03 0.54 0 5.00
18 INT247846 Positive_regulation of Narfl Positive_regulation of Positive_regulation of Ube4a 1 0.00 0.82 0 5.00
19 INT247848 Narfl Negative_regulation of Uchl1 1 0.03 0.74 0 5.00
20 INT247857 Narfl Positive_regulation of Gene_expression of Gfap 1 0.07 0.81 0 5.00
21 INT247888 Narfl Positive_regulation of CASP3 1 0.00 0.77 0 5.00
22 INT247850 Positive_regulation of Narfl Regulation of Ube4a 1 0.00 1.86 0 5.00
23 INT273772 BCKDHA Positive_regulation of Positive_regulation of NARFL 1 0.03 1.21 0 5.00
24 INT247849 Edn1 Regulation of Gene_expression of Aqp4 1 0.12 1.05 0 5.00
25 INT247852 Narfl Positive_regulation of Localization of Aqp4 1 0.08 0.81 0 5.00
26 INT247889 Positive_regulation of Narfl Positive_regulation of CASP3 1 0.00 0.84 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Open-angle Glaucoma. They are ordered first by their pain relevance and then by number of times they were reported in Open-angle Glaucoma. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT45272 Regulation of Nps 15 0.39 8.08 2.69 100.00
2 INT3777 Positive_regulation of NARFL 256 0.56 302.43 25.74 99.94
3 INT272530 Negative_regulation of Localization of NARFL 3 0.09 2.98 0.07 99.88
4 INT1981 Negative_regulation of NARFL 219 0.47 223.48 16.41 99.48
5 INT181642 Negative_regulation of Narf 2 0.01 28.07 4.01 99.28
6 INT267112 Regulation of Lmx1b 3 0.61 2.21 0.16 99.24
7 INT165400 Positive_regulation of TST 13 0.68 4.25 0.35 99.18
8 INT289984 Regulation of Narf 1 0.01 0.78 0 98.96
9 INT15367 Gene_expression of OPA1 35 0.67 24.9 5.45 98.84
10 INT24883 Regulation of OPA1 14 0.45 9.73 3.44 98.76
11 INT272274 Localization of NARFL 24 0.60 27.55 1.18 98.30
12 INT39369 Binding of NARFL 14 0.29 16.7 0.93 97.60
13 INT6726 Positive_regulation of Edn1 118 0.70 65.96 24.07 97.48
14 INT103260 Positive_regulation of Nps 35 0.48 23.8 5.67 97.32
15 INT1982 Regulation of NARFL 119 0.49 116.2 14.35 96.54
16 INT153779 Positive_regulation of Dct 2 0.18 1.28 0.29 95.80
17 INT272273 Gene_expression of NARFL 89 0.54 121.19 4.47 95.36
18 INT92835 Gene_expression of Col4a1 22 0.49 13.5 2.27 92.08
19 INT170307 Regulation of Gene_expression of Col4a1 2 0.16 1.45 0.1 92.08
20 INT144364 Negative_regulation of Lmx1b 5 0.45 3.35 2.12 91.24
21 INT60710 Gene_expression of Col7a1 217 0.78 113.2 35.2 89.08
22 INT157805 Negative_regulation of Gene_expression of Col7a1 22 0.34 12.85 3.51 89.08
23 INT272272 Positive_regulation of Gene_expression of NARFL 17 0.40 18.85 0.31 88.40
24 INT65265 Positive_regulation of Gene_expression of Col7a1 48 0.69 23.81 6.16 87.84
25 INT65258 Regulation of Gene_expression of Col7a1 17 0.55 8.26 2.57 87.84
26 INT123422 Gene_expression of Lmx1b 18 0.78 6.93 5.17 84.32
27 INT6580 Negative_regulation of Ptgs1 929 0.59 381.53 376.26 84.00
28 INT247868 Positive_regulation of Narfl 1 0.11 37.11 0.68 82.72
29 INT19716 Gene_expression of Ecd 9 0.41 2.18 0.57 81.72
30 INT164965 Gene_expression of Cle 4 0.58 3.73 0.1 81.40
31 INT243224 Regulation of Plxna2 2 0.13 1.58 0 75.40
32 INT2520 Negative_regulation of Ca2 271 0.57 72.13 83.71 75.00
33 INT231267 Localization of Ecd 3 0.18 0.84 0.12 72.92
34 INT83292 Gene_expression of MIP 35 0.75 25.22 10.14 71.00
35 INT82885 Gene_expression of Mip 7 0.65 7.89 2.76 71.00
36 INT179213 Gene_expression of Aqp3 10 0.63 5.13 0.77 71.00
37 INT267114 Positive_regulation of Lmx1b 2 0.50 0.96 0.6 70.88
38 INT121861 Regulation of BID 4 0.31 2.73 1.15 64.72
39 INT99966 Negative_regulation of Positive_regulation of NARFL 13 0.37 13.32 0.98 58.32
40 INT4822 Localization of Ca2 417 0.80 99.57 96.45 50.00
41 INT13286 Gene_expression of Ca2 317 0.67 71.58 65.01 50.00
42 INT36461 Regulation of Col4a1 10 0.26 5.43 1.17 49.92
43 INT267113 Regulation of Gene_expression of Lmx1b 2 0.62 1.36 0.44 49.28
44 INT65261 Regulation of Col7a1 18 0.55 8.7 1.33 46.40
45 INT33854 Localization of OPA1 19 0.65 10.55 5.04 45.92
46 INT171747 Gene_expression of ACD 4 0.57 4.44 0.68 37.52
47 INT289990 Positive_regulation of Gene_expression of Narf 1 0.02 0.77 0 35.28
48 INT289988 Gene_expression of Narf 1 0.02 3.35 0.67 32.80
49 INT160915 Regulation of Mmp9 16 0.35 10.25 4.07 18.64
50 INT286249 Regulation of Mfrp 1 0.25 2.14 0.1 18.64
51 INT101147 Gene_expression of Uchl1 31 0.76 14.73 13.22 14.28
52 INT159127 Gene_expression of Nps 49 0.75 16.91 12.06 13.68
53 INT93777 Negative_regulation of Rgs2 3 0.43 2.5 2.81 12.68
54 INT90044 Negative_regulation of P9Ehs1 3 0.22 1.32 1.75 12.68
55 INT184038 Negative_regulation of Socs2 5 0.31 1.68 0.51 12.68
56 INT272414 Positive_regulation of Positive_regulation of NARFL 9 0.37 12.88 0.84 6.48
57 INT22548 Positive_regulation of Casp3 483 0.70 258.78 213.07 5.00
58 INT49134 Gene_expression of Grin1 270 0.78 84.78 148.61 5.00
59 INT48953 Positive_regulation of Nos2 486 0.70 239.85 131.87 5.00
60 INT5842 Gene_expression of Gfap 372 0.78 153.71 127.71 5.00
61 INT14151 Gene_expression of Casp3 311 0.78 140.26 120.68 5.00
62 INT1080 Negative_regulation of Ache 343 0.59 108.51 72.4 5.00
63 INT5843 Positive_regulation of Gfap 184 0.70 108.2 70.21 5.00
64 INT1759 Gene_expression of TIMP1 267 0.77 133.87 59.29 5.00
65 INT6864 Positive_regulation of Gene_expression of Gfap 110 0.70 59.01 47.07 5.00
66 INT5781 Gene_expression of Edn1 190 0.78 99.1 46 5.00
67 INT27493 Negative_regulation of Casp3 114 0.56 56.89 44.63 5.00
68 INT11560 Positive_regulation of CASP3 236 0.70 184.33 39.38 5.00
69 INT130837 Gene_expression of Aqp4 205 0.78 151.23 29.63 5.00
70 INT22549 Positive_regulation of Positive_regulation of Casp3 48 0.56 29.5 23.7 5.00
71 INT6866 Regulation of Gfap 51 0.61 19.6 23.56 5.00
72 INT29704 Regulation of Casp3 51 0.56 22.13 22.79 5.00
73 INT51055 Positive_regulation of TIMP1 103 0.69 50.07 19.86 5.00
74 INT12725 Positive_regulation of Racgap1 66 0.68 32.74 19.29 5.00
75 INT107454 Positive_regulation of Stat3 43 0.68 19.63 17.69 5.00
76 INT108588 Gene_expression of CASP3 126 0.78 84.49 16.2 5.00
77 INT1758 Positive_regulation of Gene_expression of TIMP1 62 0.69 31.72 13.98 5.00
78 INT5806 Regulation of Edn1 63 0.62 23.46 13.88 5.00
79 INT107875 Phosphorylation of Stat3 49 0.80 13.18 12.66 5.00
80 INT11793 Negative_regulation of CA2 78 0.57 19.63 12.35 5.00
81 INT49555 Positive_regulation of Positive_regulation of Gfap 18 0.69 11.51 10.29 5.00
82 INT102106 Positive_regulation of Bax 48 0.67 30.62 9.28 5.00
83 INT80037 Gene_expression of BAK1 58 0.75 39.49 9.08 5.00
84 INT25585 Positive_regulation of DNAH8 39 0.70 17.96 7.85 5.00
85 INT10899 Positive_regulation of Gene_expression of Edn1 32 0.70 24.88 7.65 5.00
86 INT136304 Negative_regulation of Aqp4 54 0.59 48.42 7.4 5.00
87 INT14732 Positive_regulation of FN1 46 0.69 31.17 7.33 5.00
88 INT10104 Negative_regulation of Edn1 43 0.59 15.63 7.2 5.00
89 INT6758 Positive_regulation of Synm 12 0.43 2.57 6.83 5.00
90 INT49025 Positive_regulation of TYR 14 0.69 7.15 5.84 5.00
91 INT5490 Binding of CA2 52 0.36 9.73 5.53 5.00
92 INT78393 Gene_expression of Adm 16 0.78 8.4 4.92 5.00
93 INT97392 Gene_expression of Stat3 27 0.65 14.21 4.06 5.00
94 INT169748 Positive_regulation of Gene_expression of Aqp4 38 0.69 34.29 3.79 5.00
95 INT98624 Regulation of Aqp4 27 0.62 30.76 3.77 5.00
96 INT225965 Localization of Aqp4 26 0.81 18.85 3.75 5.00
97 INT93120 Localization of Gfap 21 0.78 8.42 3.7 5.00
98 INT88805 Protein_catabolism of CASP3 24 0.86 18.38 3.7 5.00
99 INT64310 Negative_regulation of GRIN2A 7 0.42 2.16 3.49 5.00
100 INT37110 Positive_regulation of Ptgfr 10 0.69 2.38 3.44 5.00
101 INT95272 Regulation of Gene_expression of Edn1 19 0.53 17.85 3.42 5.00
102 INT52839 Regulation of Racgap1 14 0.25 9.46 3.37 5.00
103 INT165821 Positive_regulation of Aqp4 27 0.70 24.37 3.22 5.00
104 INT5913 Binding of OPA1 12 0.41 9.33 2.92 5.00
105 INT167311 Gene_expression of Aqp5 8 0.61 1.77 2.75 5.00
106 INT88852 Protein_catabolism of Casp3 28 0.65 23.57 2.74 5.00
107 INT84599 Gene_expression of Aqp2 31 0.77 22.58 2.54 5.00
108 INT225966 Regulation of Gene_expression of Aqp4 18 0.62 20.39 2.3 5.00
109 INT106616 Gene_expression of PSMB9 35 0.72 28.4 2.29 5.00
110 INT29094 Binding of C3 39 0.37 12.65 2.27 5.00
111 INT112267 Positive_regulation of Rgc32 10 0.39 8.1 2.09 5.00
112 INT9906 Binding of CYP2E1 15 0.40 1.89 2.08 5.00
113 INT140991 Negative_regulation of Stat3 15 0.53 7.55 2.04 5.00
114 INT114434 Gene_expression of Calcrl 10 0.78 5.81 1.83 5.00
115 INT84595 Negative_regulation of Aqp2 11 0.58 4.88 1.78 5.00
116 INT104883 Positive_regulation of Positive_regulation of Bax 4 0.45 4.05 1.74 5.00
117 INT2074 Negative_regulation of CA1 6 0.58 4.44 1.68 5.00
118 INT164480 Negative_regulation of Gene_expression of Aqp4 14 0.58 10.84 1.52 5.00
119 INT247885 Regulation of Thy1 8 0.33 5.25 1.44 5.00
120 INT69785 Positive_regulation of MYOC 8 0.70 6.24 1.36 5.00
121 INT32300 Binding of Ptgfr 3 0.36 1.51 1.36 5.00
122 INT73553 Gene_expression of Aqp1 23 0.67 4.65 1.34 5.00
123 INT84805 Negative_regulation of Aqp5 4 0.43 0.35 1.24 5.00
124 INT126534 Negative_regulation of ROCK1 18 0.49 14.32 1.13 5.00
125 INT167182 Binding of Psd 9 0.41 13.08 1.06 5.00
126 INT71601 Positive_regulation of ACD 11 0.60 6.55 0.9 5.00
127 INT84571 Gene_expression of Rgs2 6 0.67 3.18 0.89 5.00
128 INT159668 Positive_regulation of Bad 8 0.45 6.32 0.89 5.00
129 INT272275 Regulation of Positive_regulation of NARFL 8 0.36 16.68 0.86 5.00
130 INT235951 Positive_regulation of Positive_regulation of Aqp4 4 0.57 5.13 0.75 5.00
131 INT141977 Positive_regulation of Calcrl 2 0.70 0.93 0.75 5.00
132 INT272415 Negative_regulation of Gene_expression of NARFL 14 0.34 17.62 0.73 5.00
133 INT289989 Positive_regulation of Narf 1 0.02 3.85 0.73 5.00
134 INT84570 Positive_regulation of Gene_expression of Rgs2 3 0.50 0.67 0.67 5.00
135 INT84596 Negative_regulation of Gene_expression of Aqp2 3 0.58 8.49 0.6 5.00
136 INT115292 Regulation of TGFB2 4 0.17 2.79 0.58 5.00
137 INT264594 Negative_regulation of Binding of CA2 4 0.20 1.1 0.52 5.00
138 INT289983 Regulation of Positive_regulation of Narf 1 0.01 1.12 0.46 5.00
139 INT218919 Negative_regulation of Xiap 4 0.32 4.61 0.46 5.00
140 INT263240 Regulation of Socs2 2 0.02 0.96 0.46 5.00
141 INT122156 Binding of CA1 3 0.47 1.52 0.44 5.00
142 INT34976 Positive_regulation of Gene_expression of OPA1 4 0.43 4.21 0.4 5.00
143 INT232743 Positive_regulation of LAMB2 5 0.06 1.94 0.37 5.00
144 INT247859 Negative_regulation of Aqp3 2 0.10 1.52 0.35 5.00
145 INT122950 Binding of BAK1 16 0.41 12.85 0.31 5.00
146 INT289986 Positive_regulation of Transcription of Rbp3 1 0.04 1 0.27 5.00
147 INT289994 Transcription of Rbp3 1 0.06 0.99 0.27 5.00
148 INT247863 Positive_regulation of Negative_regulation of Aqp4 3 0.45 2.63 0.25 5.00
149 INT289985 Positive_regulation of Positive_regulation of Rgc32 1 0.01 0.93 0.24 5.00
150 INT247870 Negative_regulation of Localization of Aqp4 3 0.43 2 0.24 5.00
151 INT289992 Phosphorylation of Cntf 1 0.30 1 0.22 5.00
152 INT289991 Phosphorylation of Narf 1 0.02 0.91 0.21 5.00
153 INT289982 Phosphorylation of CNTF 1 0.79 0.99 0.21 5.00
154 INT274273 Regulation of Gene_expression of NARFL 3 0.10 4.39 0.2 5.00
155 INT164966 Binding of Cle 2 0.32 0.91 0.19 5.00
156 INT108300 Positive_regulation of BCKDHA 3 0.39 1.74 0.18 5.00
157 INT215814 Negative_regulation of Gene_expression of Aqp1 2 0.31 0.25 0.17 5.00
158 INT58816 Regulation of Regulation of NARFL 2 0.11 1.39 0.16 5.00
159 INT178607 Binding of CASP3 5 0.19 1.06 0.16 5.00
160 INT263243 Regulation of Gene_expression of Rgs2 1 0.27 1.65 0.15 5.00
161 INT97050 Negative_regulation of Uchl1 2 0.22 2.28 0.14 5.00
162 INT247865 Gene_expression of Narfl 1 0.09 9.22 0.13 5.00
163 INT215820 Negative_regulation of Aqp1 3 0.23 0.83 0.1 5.00
164 INT247866 Localization of Narfl 1 0.10 1.98 0.09 5.00
165 INT289993 Positive_regulation of Positive_regulation of Narf 1 0.02 0.85 0.08 5.00
166 INT247873 Binding of Narfl 1 0.05 1.33 0.07 5.00
167 INT270857 Protein_catabolism of ACD 1 0.07 0.77 0.07 5.00
168 INT286247 Positive_regulation of Gene_expression of Calcrl 1 0.70 2.41 0.07 5.00
169 INT247882 Positive_regulation of Ube4a 4 0.01 2.17 0.07 5.00
170 INT144918 Gene_expression of Thy1 5 0.62 4.39 0.06 5.00
171 INT247883 Negative_regulation of Gene_expression of Aqp3 1 0.34 0.56 0.05 5.00
172 INT247867 Positive_regulation of Positive_regulation of Narfl 1 0.11 5.16 0.05 5.00
173 INT99965 Positive_regulation of Negative_regulation of NARFL 6 0.40 4.5 0.04 5.00
174 INT311458 Positive_regulation of Gene_expression of Cle 1 0.23 0.83 0.04 5.00
175 INT263238 Localization of Rgs2 2 0.75 0.96 0.03 5.00
176 INT263241 Localization of Figf 1 0.04 0.38 0.03 5.00
177 INT247878 Negative_regulation of Positive_regulation of Narfl 1 0.06 2.14 0.03 5.00
178 INT247881 Regulation of Ube4a 1 0.00 3.69 0.03 5.00
179 INT289987 Negative_regulation of Morn4 1 0.03 1 0.03 5.00
180 INT247871 Negative_regulation of Thy1 8 0.54 7.23 0.03 5.00
181 INT263239 Negative_regulation of Localization of Rgs2 1 0.43 0.96 0.03 5.00
182 INT247874 Positive_regulation of Negative_regulation of Thy1 1 0.14 0.51 0 5.00
183 INT263242 Regulation of Rgs2 1 0.27 0.59 0 5.00
184 INT247864 Positive_regulation of Protein_catabolism of Aqp4 1 0.45 0.41 0 5.00
185 INT247858 Protein_catabolism of Ube4a 1 0.01 0.52 0 5.00
186 INT247872 Positive_regulation of Gene_expression of Narfl 1 0.07 0.44 0 5.00
187 INT247862 Regulation of Narfl 1 0.06 0.67 0 5.00
188 INT247869 Regulation of Positive_regulation of Narfl 1 0.06 1.85 0 5.00
189 INT247877 Negative_regulation of Gene_expression of Narfl 1 0.06 1.05 0 5.00
190 INT318313 Regulation of TST 2 0.34 0.23 0 5.00
191 INT311459 Negative_regulation of Cle 1 0.20 0.3 0 5.00
192 INT286246 Binding of am 1 0.00 0.41 0 5.00
193 INT247884 Negative_regulation of Gene_expression of Uchl1 1 0.21 1.22 0 5.00
194 INT311457 Positive_regulation of Cle 1 0.22 1.22 0 5.00
195 INT247860 Regulation of Uchl1 1 0.14 1.46 0 5.00
196 INT247876 Negative_regulation of Localization of Narfl 1 0.06 0.94 0 5.00
197 INT247875 Gene_expression of Ube4a 1 0.01 0.94 0 5.00
198 INT247880 Protein_catabolism of Aqp4 1 0.64 1.35 0 5.00
199 INT247879 Regulation of Gene_expression of Narfl 1 0.04 0.66 0 5.00
200 INT286250 Positive_regulation of RAMP2 1 0.33 0.5 0 5.00
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