D:Ophthalmoplegia

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Disease Term
Synonyms External Ophthalmoplegia, EXTERNAL OPHTHALMOPLEGIAS, Internal Ophthalmoplegia, INTERNAL OPHTHALMOPLEGIAS, Oculomotor Paralysis, OPHTHALMOPARESES, OPHTHALMOPARESIS, OPHTHALMOPLEGIA EXTERNAL, OPHTHALMOPLEGIA INTERNAL, Ophthalmoplegias, OPHTHALMOPLEGIAS EXTERNAL
Documents 651
Hot Single Events 31
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Ophthalmoplegia. They are ordered first by their relevance to Ophthalmoplegia and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT219154 Binding of HMGB1 and TLR4 2 0.17 4.45 0.93 41.96
2 INT204943 Il6 Regulation of Slc39a14 1 0.00 0.54 0.36 5.00
3 INT262307 CAPNS1 Regulation of TAF9 1 0.04 1.23 0.33 5.00
4 INT336946 Binding of ITGA4 and VCAM1 1 0.03 2.02 0.21 5.00
5 INT243524 Positive_regulation of Binding of NTF3 and SOX10 1 0.01 0.54 0.14 5.00
6 INT243525 Binding of NTF3 and SOX10 1 0.01 0.54 0.14 5.00
7 INT199667 Cep290 Regulation of Atf4 1 0.04 1.96 0.09 5.00
8 INT199666 Cntln Regulation of Atf4 1 0.00 1.95 0.09 5.00
9 INT220697 Binding of CHRNE and DBP 1 0.02 1.15 0.08 5.00
10 INT220698 Binding of CHRNE and SFTPA1 1 0.01 0.75 0.06 5.00
11 INT235168 Binding of Crx and Atxn7 1 0.11 0.81 0.03 5.00
12 INT199665 Binding of Fxn and Lamtor3 1 0.00 0.16 0.03 5.00
13 INT239406 Binding of MTTP and TAOK1 1 0.02 0.51 0 5.00
14 INT235165 Atxn3 Regulation of Transcription of Crebbp 1 0.02 0.3 0 5.00
15 INT239407 Binding of MTTP and PADI1 1 0.23 0.5 0 5.00
16 INT235166 Binding of Hdac3 and Atxn1 1 0.02 0.28 0 5.00
17 INT320848 Binding of Npc1 and Npc2 1 0.39 0 0 5.00
18 INT239408 Binding of PADI1 and TAOK1 1 0.01 0.51 0 5.00
19 INT235167 Binding of Hdac3 and Ncor2 1 0.01 0.28 0 5.00
20 INT235164 Binding of Atxn1 and Ncor2 1 0.15 0.42 0 5.00
21 INT251822 Binding of POLG and C10orf2 1 0.42 0.29 0 5.00
22 INT235169 Gene_expression of Dnaja1 Negative_regulation of Binding of Atxn1 1 0.09 0.47 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Ophthalmoplegia. They are ordered first by their pain relevance and then by number of times they were reported in Ophthalmoplegia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT59466 Gene_expression of ISYNA1 204 0.77 112.57 35.48 100.00
2 INT76092 Localization of ISYNA1 10 0.66 7.72 3.11 100.00
3 INT42425 Gene_expression of Mmd 2 0.75 1.68 0.91 99.80
4 INT138694 Negative_regulation of NINL 1 0.38 0.97 0.48 99.60
5 INT102696 Binding of MRP63 4 0.46 3.68 0.27 99.04
6 INT443 Localization of POMC 1020 0.81 284.52 443.17 98.84
7 INT239412 Binding of ABL1 8 0.28 5.39 0.18 96.40
8 INT96720 Positive_regulation of GNA11 2 0.60 0.95 0.41 95.12
9 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82 93.24
10 INT274203 Positive_regulation of PABPN1 1 0.16 2.41 0.37 92.84
11 INT354726 Binding of Tymp 1 0.30 1.08 0.23 92.24
12 INT138555 Negative_regulation of Tymp 3 0.39 3.31 0.74 92.00
13 INT211375 Regulation of Gene_expression of TYMP 2 0.43 2.44 0.22 91.80
14 INT120722 Gene_expression of TYMP 35 0.75 19.26 1.31 91.76
15 INT158837 Binding of POLG 4 0.37 4.69 0.44 90.36
16 INT70265 Regulation of MRI1 42 0.39 30.95 14.18 89.68
17 INT309244 Transcription of HSPA5 1 0.16 2.75 0.36 89.24
18 INT3795 Positive_regulation of Ighm 46 0.68 22.43 6.47 89.00
19 INT208140 Localization of PITX1 2 0.73 6.18 0.14 87.60
20 INT75299 Binding of Atxn3 8 0.43 5.3 0.26 87.40
21 INT27683 Gene_expression of Acpp 4 0.66 4.13 0.41 87.24
22 INT99555 Gene_expression of EBI3 3 0.09 2.6 0.9 86.88
23 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 86.12
24 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 85.72
25 INT242419 Negative_regulation of Gene_expression of Sdc1 1 0.03 1.31 0.03 84.96
26 INT61316 Gene_expression of Coq10a 59 0.73 32.81 3.95 84.12
27 INT179856 Gene_expression of Sdc1 4 0.75 3.88 0.03 83.40
28 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 81.64
29 INT37722 Gene_expression of NCAM1 103 0.75 81.57 14.18 81.64
30 INT15054 Gene_expression of Mme 48 0.77 42.52 10.63 81.64
31 INT92386 Gene_expression of Tnfrsf8 14 0.54 13.55 1.67 81.64
32 INT135219 Binding of Polg 1 0.08 1.04 0.08 79.80
33 INT79121 Binding of CHSY1 2 0.27 2.39 0.58 79.08
34 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 78.84
35 INT36309 Negative_regulation of DIO2 18 0.57 6.42 4.51 78.64
36 INT117662 Gene_expression of ABL1 21 0.69 18.76 0.39 78.00
37 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 77.96
38 INT9657 Positive_regulation of Gene_expression of Il6 237 0.70 180.45 63.6 77.96
39 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 77.92
40 INT138715 Gene_expression of POLG 12 0.66 6.97 0.23 77.80
41 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 77.56
42 INT171666 Regulation of GOPC 117 0.39 40.41 15.47 75.92
43 INT148717 Binding of NR0B1 6 0.34 5.4 0.25 74.56
44 INT64538 Binding of TNNI3 17 0.48 11.65 1.83 74.56
45 INT8959 Binding of Gnb5 17 0.40 31.38 5.1 73.28
46 INT1735 Gene_expression of HSD11B1 199 0.75 257.87 11.5 71.72
47 INT251830 Binding of TYMP 2 0.13 4.36 0.37 71.52
48 INT272511 Positive_regulation of DMPK 8 0.54 6.85 0.72 70.48
49 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 69.88
50 INT335980 Regulation of Igfals 1 0.17 2.26 0.12 69.76
51 INT320840 Binding of Npc2 1 0.46 1.81 0 68.56
52 INT211756 Phosphorylation of Mmd 1 0.17 1.44 0.03 67.92
53 INT240424 Binding of Ctsa 4 0.20 3.94 0.16 66.92
54 INT11937 Localization of Il6 228 0.81 139.83 64.39 65.96
55 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 65.44
56 INT74563 Positive_regulation of Gene_expression of ROS1 258 0.61 168.18 34.08 65.44
57 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 63.04
58 INT235132 Gene_expression of Ppp2r2b 1 0.55 2.31 0.11 62.64
59 INT66331 Gene_expression of Cacna1a 101 0.78 49.58 46.32 62.64
60 INT181809 Gene_expression of Atxn1 81 0.77 28.66 1.42 62.64
61 INT235157 Gene_expression of Atxn2 3 0.68 6.74 1.23 62.64
62 INT55315 Gene_expression of Tbp 32 0.74 14.6 1.17 62.64
63 INT135045 Gene_expression of Atxn3 34 0.78 11.59 0.36 62.64
64 INT235160 Gene_expression of Atxn7 1 0.56 2 0.04 62.64
65 INT331984 Localization of PTP4A1 1 0.78 4.41 0.09 59.44
66 INT82610 Positive_regulation of SRC 53 0.67 26.89 7.27 56.88
67 INT211758 Binding of Mmd 1 0.13 3.09 0.1 56.80
68 INT10009 Positive_regulation of TRH 31 0.67 8.94 11.03 52.88
69 INT82913 Regulation of Ppara 15 0.61 10.66 3.03 52.20
70 INT98607 Regulation of Regulation of TNF 8 0.44 6.95 2.56 52.20
71 INT235138 Gene_expression of Atxn8os 2 0.76 6.89 1.05 51.12
72 INT235151 Gene_expression of Atxn10 1 0.34 0.73 0 50.88
73 INT9660 Regulation of TNF 363 0.62 312.94 139.99 50.28
74 INT65057 Regulation of Nfkb1 28 0.47 16.48 11.62 49.12
75 INT293961 Binding of PITX1 1 0.31 1.73 0.1 44.16
76 INT2597 Negative_regulation of ACHE 82 0.59 46.36 8.62 43.28
77 INT232634 Localization of Opa1 2 0.75 1.11 0 42.64
78 INT184288 Localization of HMGB1 20 0.61 14.5 3.84 41.96
79 INT50080 Binding of APOE 38 0.45 29.61 2.67 40.60
80 INT134651 Binding of TLR4 89 0.48 66.96 23.19 40.16
81 INT305170 Gene_expression of Man2c1 1 0.05 1.89 0 35.20
82 INT112968 Negative_regulation of Gnb5 5 0.34 7.79 1.81 34.16
83 INT44426 Localization of BRD2 6 0.78 4.02 2.59 31.40
84 INT305171 Binding of Man2c1 1 0.03 1.75 0 28.44
85 INT163461 Regulation of ABL1 8 0.32 5.98 0.14 27.28
86 INT20631 Positive_regulation of CHKB 166 0.69 109.86 17.92 24.32
87 INT189750 Negative_regulation of Positive_regulation of CHKB 4 0.26 2.36 0.38 24.32
88 INT192856 Regulation of Gene_expression of Ppp2r1a 2 0.16 0.62 0.12 23.96
89 INT235150 Regulation of Gene_expression of Ppp2r2b 1 0.32 0.48 0.11 23.96
90 INT235929 Regulation of Positive_regulation of Alms1 2 0.02 2.84 1.02 23.64
91 INT192857 Gene_expression of Ppp2r1a 6 0.47 1.74 0.19 23.52
92 INT220701 Regulation of Negative_regulation of ACHE 2 0.25 1.06 0 21.44
93 INT200435 Binding of polymerase 6 0.16 5.56 0.47 20.40
94 INT95414 Positive_regulation of Alms1 40 0.41 20.3 8.1 20.28
95 INT31136 Binding of Cacna1a 28 0.45 30.76 17.35 17.92
96 INT277821 Positive_regulation of Negative_regulation of INCENP 2 0.03 0.89 0.12 17.04
97 INT172551 Negative_regulation of INCENP 38 0.07 20.83 3.14 16.16
98 INT243533 Positive_regulation of SOX10 1 0.35 3.93 0.92 13.80
99 INT17275 Gene_expression of HIVEP1 267 0.75 232.07 24.06 12.36
100 INT134902 Positive_regulation of Tymp 11 0.37 3.06 0.53 9.72
101 INT5207 Negative_regulation of Alms1 70 0.41 41.56 13.68 9.12
102 INT243208 Negative_regulation of Protein_catabolism of Alms1 2 0.06 2.21 0.26 9.12
103 INT10478 Protein_catabolism of Alms1 25 0.47 12.95 7.19 8.56
104 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 6.72
105 INT67156 Binding of ITGA4 6 0.14 2.63 1.03 6.52
106 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
107 INT49750 Negative_regulation of CPOX 735 0.58 360.06 274.19 5.00
108 INT9987 Gene_expression of Abat 296 0.78 95.46 226.34 5.00
109 INT6665 Gene_expression of FOS 520 0.77 165.31 217.66 5.00
110 INT2211 Negative_regulation of Abat 267 0.59 66.51 200.98 5.00
111 INT50670 Gene_expression of CPOX 763 0.76 442.13 195.02 5.00
112 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 5.00
113 INT2910 Regulation of Abat 169 0.62 36.95 153.53 5.00
114 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
115 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
116 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
117 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 5.00
118 INT14049 Positive_regulation of GRIN1 102 0.70 48.31 71.06 5.00
119 INT8357 Gene_expression of KNG1 153 0.75 77.26 68.66 5.00
120 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 5.00
121 INT11491 Positive_regulation of KNG1 128 0.67 60.41 58.74 5.00
122 INT74389 Gene_expression of Gdnf 131 0.78 58.52 57.06 5.00
123 INT17458 Negative_regulation of Gene_expression of FOS 98 0.57 36.77 55.69 5.00
124 INT251 Regulation of INS 398 0.62 232.47 55.04 5.00
125 INT3213 Gene_expression of Ins1 511 0.76 357.59 53.32 5.00
126 INT19488 Localization of ABAT 56 0.69 21.51 50.56 5.00
127 INT42980 Gene_expression of GAD1 139 0.69 94.77 45.11 5.00
128 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 5.00
129 INT27493 Negative_regulation of Casp3 114 0.56 56.89 44.63 5.00
130 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 5.00
131 INT173693 Localization of Gopc 249 0.65 70.49 38.81 5.00
132 INT8747 Positive_regulation of Ins1 221 0.69 154.28 35.15 5.00
133 INT47710 Negative_regulation of GRIN1 71 0.57 25.57 34.24 5.00
134 INT16960 Gene_expression of Crp 166 0.76 116.21 34.07 5.00
135 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98 5.00
136 INT6302 Binding of IFNA1 196 0.48 133.85 32.73 5.00
137 INT62830 Gene_expression of VCAM1 149 0.78 125.23 32.4 5.00
138 INT9655 Regulation of Il6 98 0.62 70.92 31.95 5.00
139 INT34729 Positive_regulation of IFN1@ 233 0.67 128.04 30.38 5.00
140 INT5117 Negative_regulation of Gene_expression of IL2 118 0.59 52.33 29.96 5.00
141 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 5.00
142 INT5653 Positive_regulation of ELANE 136 0.70 72.78 27.94 5.00
143 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7 5.00
144 INT3777 Positive_regulation of NARFL 256 0.56 302.43 25.74 5.00
145 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 5.00
146 INT49196 Gene_expression of SELE 105 0.78 107.29 22.92 5.00
147 INT8580 Gene_expression of ELANE 132 0.75 62.98 21.79 5.00
148 INT73625 Gene_expression of PPARG 108 0.78 104.85 21.42 5.00
149 INT5328 Positive_regulation of CD4 191 0.69 133.43 21.31 5.00
150 INT105021 Binding of GOPC 187 0.40 60.39 20.38 5.00
151 INT31874 Negative_regulation of Gene_expression of Abat 31 0.42 12.22 20.31 5.00
152 INT11938 Positive_regulation of Localization of Il6 61 0.70 35.72 18.25 5.00
153 INT133647 Negative_regulation of HDAC9 149 0.57 106.84 17.9 5.00
154 INT24225 Gene_expression of Alms1 93 0.62 52.75 16.93 5.00
155 INT10721 Gene_expression of BDNF-AS 119 0.76 72.8 16.29 5.00
156 INT11685 Regulation of CSF2 99 0.59 58.82 15.9 5.00
157 INT71634 Gene_expression of SLC6A3 45 0.78 13.48 15.23 5.00
158 INT34952 Regulation of ABAT 28 0.61 6.05 14.39 5.00
159 INT22301 Positive_regulation of Gene_expression of CSF2 66 0.63 59.49 14.24 5.00
160 INT65697 Positive_regulation of GRIN3B 23 0.69 12.52 13.78 5.00
161 INT69435 Negative_regulation of ROS1 74 0.51 50.38 13.71 5.00
162 INT14572 Binding of INS 205 0.48 175.43 13.38 5.00
163 INT8210 Positive_regulation of Gene_expression of INS 188 0.68 146.57 12.83 5.00
164 INT49975 Binding of SLC6A3 34 0.47 9.86 12.41 5.00
165 INT11793 Negative_regulation of CA2 78 0.57 19.63 12.35 5.00
166 INT178338 Gene_expression of Tbx15 50 0.65 38.65 12.19 5.00
167 INT73829 Positive_regulation of Gene_expression of VCAM1 41 0.61 35.96 11.92 5.00
168 INT28872 Positive_regulation of CSRP1 49 0.70 47.23 11.7 5.00
169 INT4498 Gene_expression of F2 83 0.65 57.4 10.8 5.00
170 INT67048 Gene_expression of ITGA4 58 0.75 28.93 10.16 5.00
171 INT123701 Negative_regulation of VDR 61 0.59 48.94 9.67 5.00
172 INT1118 Gene_expression of C6orf25 73 0.77 47.24 9.1 5.00
173 INT17024 Gene_expression of COL1A2 69 0.77 36.38 8.29 5.00
174 INT26551 Positive_regulation of Gene_expression of KNG1 19 0.67 11.05 7.98 5.00
175 INT24978 Binding of SFTPA1 22 0.47 15.09 7.76 5.00
176 INT157959 Binding of AQP4 32 0.48 43.44 7.44 5.00
177 INT26462 Gene_expression of DNAH8 44 0.78 19.36 7.31 5.00
178 INT11957 Negative_regulation of LPA 52 0.59 39.09 6.84 5.00
179 INT39516 Gene_expression of Alb 81 0.75 30.08 6.59 5.00
180 INT49212 Negative_regulation of GAD1 23 0.59 22.15 6.54 5.00
181 INT11814 Positive_regulation of Alb 43 0.63 31.71 6.28 5.00
182 INT57232 Binding of Casp3 22 0.36 9.42 6.2 5.00
183 INT1126 Negative_regulation of CD79A 46 0.59 31.07 6 5.00
184 INT22839 Gene_expression of F2 31 0.74 15.53 5.56 5.00
185 INT5490 Binding of CA2 52 0.36 9.73 5.53 5.00
186 INT62336 Positive_regulation of Hdc 38 0.70 14.45 5.51 5.00
187 INT53184 Negative_regulation of CYP27A1 46 0.57 16.04 5.28 5.00
188 INT10100 Binding of ELANE 22 0.47 15.32 5.19 5.00
189 INT49375 Regulation of Localization of Il6 16 0.62 4.54 5.08 5.00
190 INT62822 Positive_regulation of Gene_expression of SELE 22 0.66 28.04 4.97 5.00
191 INT10138 Negative_regulation of Gene_expression of KNG1 13 0.57 9.57 4.9 5.00
192 INT51030 Negative_regulation of LMOD1 9 0.44 5.83 4.58 5.00
193 INT115074 Positive_regulation of GRIA1 10 0.67 2.66 4.48 5.00
194 INT8743 Positive_regulation of Gcg 19 0.65 10.63 4.43 5.00
195 INT3405 Gene_expression of BCAR1 14 0.71 8.89 4.02 5.00
196 INT84430 Negative_regulation of Smpd1 22 0.59 10.33 3.95 5.00
197 INT28673 Gene_expression of APOB 51 0.73 34.02 3.95 5.00
198 INT98624 Regulation of Aqp4 27 0.62 30.76 3.77 5.00
199 INT119446 Positive_regulation of Gnb5 6 0.58 6.47 3.72 5.00
200 INT168677 Negative_regulation of ACOT1 14 0.27 6.29 3.52 5.00
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