D:Opiate Addiction

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Disease Term
Synonyms Abuse Narcotic, Abuses Narcotic, Addiction Narcotic, Addiction Opiate, Dependence Narcotic, Dependence Opiate, Disorder Opioid Related, HEROIN ABUSE, Heroin Addiction, HEROIN DEPENDENCE, Heroin Overdose
Documents 5034
Hot Single Events 200
Hot Interactions 42

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Opiate Addiction. They are ordered first by their relevance to Opiate Addiction and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT109958 Binding of CRH and HPSE 1 0.10 0.72 1.46 100.00
2 INT142128 Nrgn Regulation of Creb1 1 0.38 0.25 0.89 100.00
3 INT142129 Nrgn Regulation of Camk2a 1 0.48 0.25 0.89 100.00
4 INT162105 Nr4a3 Regulation of ACPT-I 1 0.10 0.26 1.38 99.52
5 INT139190 Binding of Fadd and Fas 4 0.38 2.65 1.71 99.18
6 INT139188 Binding of Daxx and Fas 1 0.03 0.55 1.14 99.18
7 INT139189 Binding of Daxx and Fadd 1 0.03 0.27 0.57 99.10
8 INT137144 ITIH4 Regulation of OPRM1 1 0.20 1.13 1.16 98.56
9 INT214368 Pik3cb Regulation of Ubqln1 1 0.01 0.36 0.68 98.56
10 INT137145 HIVEP1 Regulation of OPRM1 1 0.10 0.7 0.64 98.56
11 INT123869 Binding of GNAS and OPRK1 1 0.00 0.37 0.7 98.12
12 INT135446 Map2k1 Positive_regulation of Mapk3 1 0.54 0.25 0.91 95.84
13 INT168229 Oprm1 Regulation of Cea 1 0.10 0.26 1.3 95.60
14 INT43647 Binding of Eef1a1 and Man2a2 1 0.16 0.23 0.7 95.36
15 INT69031 IL12A Positive_regulation of IFNA1 9 0.13 4.23 1.52 94.68
16 INT300079 IL12A Positive_regulation of Positive_regulation of IFNA1 1 0.05 2.14 0 94.68
17 INT300063 IL12A Positive_regulation of IL12A Positive_regulation of IFNA1 1 0.03 2.14 0 94.68
18 INT159454 Binding of Inadl2 and Ppidl1 1 0.03 1.08 0.7 94.64
19 INT209132 Binding of Drd2 and Riok3 1 0.01 1.57 1.16 94.48
20 INT112153 Regulation of Binding of Oprm1 and Rtcd1 1 0.00 0.09 0.87 93.48
21 INT124925 Negative_regulation of Slc6a1 Negative_regulation of Localization of Pag1 1 0.00 0.61 1.3 93.00
22 INT124926 Negative_regulation of Prkaca Negative_regulation of Localization of Pag1 1 0.00 0.61 1.3 93.00
23 INT112154 Binding of Oprm1 and Rtcd1 1 0.00 0.09 0.81 93.00
24 INT148257 NR4A2 Regulation of Gene_expression of SLC6A3 1 0.60 0.4 0.59 90.48
25 INT137137 Binding of HIVEP1 and ICAM1 1 0.01 0.68 0.51 90.16
26 INT108469 Tacr1 Regulation of Transcription of Drd2 1 0.07 0.14 1.2 89.36
27 INT137141 Binding of HIVEP1 and ITIH4 2 0.16 1.44 0.56 89.28
28 INT128654 ITIH4 Regulation of Gene_expression of CCL16 1 0.02 2.69 1.79 87.92
29 INT52383 Binding of Gs and Ptprg 1 0.00 0.48 0.44 87.12
30 INT182704 Binding of NPFF and TP53INP2 1 0.01 0.73 3.28 86.12
31 INT113318 SGCG Negative_regulation of SLC35A2 1 0.46 0.16 0.63 85.68
32 INT69506 CA2 Positive_regulation of PRKCA 1 0.50 0.42 0.98 85.44
33 INT6931 Binding of Oprk1 and Pdyn 2 0.24 0.92 1.92 85.40
34 INT128652 ITIH4 Regulation of Gene_expression of CCR5 1 0.36 1.46 0.93 85.40
35 INT128655 ITIH4 Regulation of Gene_expression of CCR3 1 0.36 1.45 0.92 85.40
36 INT128653 ITIH4 Regulation of Gene_expression of MIP 1 0.23 1.44 0.92 85.40
37 INT123077 Cacna1c Negative_regulation of Gene_expression of Dbi 1 0.05 0.71 0.7 84.96
38 INT137142 Binding of ITIH4 and Positive_regulation of Localization of TNF 1 0.40 0.71 0.66 84.68
39 INT76769 Negative_regulation of Binding of HTR1E and Gs 1 0.00 0.44 0.72 84.12
40 INT89314 Binding of CRYGS and OPRM1 1 0.07 0.08 0.91 83.28
41 INT76770 Binding of HTR1E and Gs 1 0.00 0.87 1.42 83.08
42 INT113242 TNF Regulation of Transcription of OPRM1 2 0.45 1.53 1.19 80.28
43 INT141245 Prkaca Regulation of Gene_expression of Th 1 0.15 0.17 1.17 79.68
44 INT141246 Trib3 Regulation of Gene_expression of Th 1 0.02 0.17 1.17 79.68
45 INT150191 CEACAM3 Positive_regulation of Gene_expression of FOS 1 0.34 0.14 1.16 78.92
46 INT209130 Binding of Riok3 and Sugt1 1 0.00 0.44 0.4 78.80
47 INT209133 Binding of Bcl2a1a and Riok3 1 0.00 0.44 0.4 78.80
48 INT256299 Binding of Efnb1 and Ephb1 1 0.02 1.22 1.42 78.48
49 INT96796 ITIH4 Regulation of Gene_expression of OPRM1 2 0.20 0.89 1.41 76.04
50 INT137140 HIVEP1 Regulation of Gene_expression of OPRM1 1 0.25 0.69 0.66 76.04
51 INT150621 Binding of Oprm1 and Oprd1 1 0.00 0.08 1.02 75.84
52 INT63859 Oprm1 Negative_regulation of Oprm1 1 0.10 0.08 0.86 75.76
53 INT63858 Oprm1 Negative_regulation of Penk 1 0.05 0.08 0.86 75.76
54 INT300081 Binding of JAK2 and TYK2 1 0.09 1.13 0 75.68
55 INT107933 Oprm1 Positive_regulation of Gene_expression of Mastl 1 0.33 0.61 0.71 75.00
56 INT106825 Ednra Negative_regulation of Igf1 1 0.07 0.07 0.2 75.00
57 INT214372 Ptprq Positive_regulation of Akt1 1 0.04 0.88 1.43 72.08
58 INT214369 Pik3cb Positive_regulation of Akt1 1 0.56 0.87 1.41 72.08
59 INT245347 Binding of Penk and Vta1 1 0.05 0.14 1.53 71.08
60 INT141244 Fos Regulation of Prkaca 1 0.18 0.07 1.24 67.44
61 INT124547 Trib3 Regulation of Regulation of Th 1 0.02 0.79 2.64 65.40
62 INT161865 Mors1 Positive_regulation of Prkcg 1 0.00 0.12 1.47 63.84
63 INT161871 Mors1 Positive_regulation of GRIN1 1 0.01 0.12 1.46 63.84
64 INT137139 ITIH4 Positive_regulation of OPRM1 1 0.37 0.67 0.72 63.72
65 INT161870 OPRM1 Positive_regulation of Prkcg 1 0.01 0.12 1.47 63.60
66 INT161858 OPRM1 Positive_regulation of GRIN1 1 0.50 0.12 1.45 63.60
67 INT161860 OPRM1 Positive_regulation of OPRM1 Positive_regulation of GRIN1 1 0.56 0.12 1.45 63.60
68 INT315334 Binding of CYP3A4 and CDIPT 3 0.04 0.85 0.59 62.92
69 INT139191 Binding of Fas and RFFL 1 0.00 0.61 1.22 62.52
70 INT139192 RFFL Positive_regulation of Fas 1 0.00 0.3 0.61 62.52
71 INT127133 Positive_regulation of OPRM1 Positive_regulation of Protein_catabolism of SUCLG2 1 0.20 0.2 1.1 62.44
72 INT155086 CASP1 Negative_regulation of DAXX 1 0.21 1.26 0.45 62.16
73 INT111221 MMEL1 Negative_regulation of HMOX1 1 0.01 1 1.16 61.96
74 INT209131 Binding of Bcl2a1a and Drd2 1 0.22 0.45 0.62 61.68
75 INT155085 CASP1 Negative_regulation of CASP8 1 0.29 1.25 0.44 60.32
76 INT51543 Positive_regulation of Binding of Oxt and Penk 1 0.56 0.05 0.94 54.40
77 INT51542 Negative_regulation of Binding of Avp and Penk 1 0.46 0.05 0.94 54.40
78 INT51544 Binding of Oxt and Penk 1 0.54 0.05 0.94 54.40
79 INT51541 Positive_regulation of Binding of Avp and Penk 1 0.74 0.05 0.94 54.40
80 INT51545 Binding of Avp and Penk 1 0.51 0.05 0.94 54.40
81 INT233669 gr Positive_regulation of Transcription of Nfkbia 1 0.26 0.33 0.64 54.20
82 INT233671 gr Positive_regulation of Transcription of Tsc22d3 1 0.44 0.33 0.64 54.20
83 INT297487 Negative_regulation of Slc1a2 Negative_regulation of Positive_regulation of Ltp 1 0.01 0.46 1.03 53.60
84 INT297486 Slc1a2 Negative_regulation of Positive_regulation of Ltp 1 0.01 0.45 1.02 51.36
85 INT97863 Binding of NOS1 and GRHPR 1 0.05 0.23 0.77 50.96
86 INT168612 Negative_regulation of Nos1 Negative_regulation of Positive_regulation of Mmp9 1 0.23 0.45 1.62 50.36
87 INT168607 Negative_regulation of Nos1 Negative_regulation of Mmp9 1 0.23 0.45 1.61 50.04
88 INT136693 Gtf3a Positive_regulation of Ctnnb1 1 0.05 0 0 50.00
89 INT137138 ITIH4 Positive_regulation of Positive_regulation of OPRM1 1 0.42 0.55 0.59 47.64
90 INT168609 Binding of Itgb1 and Mmp9 1 0.02 0.41 1.58 46.88
91 INT168611 Binding of Mmp9 and Ndor1 1 0.29 0.41 1.57 46.88
92 INT168608 Binding of Grin2b and Mmp9 1 0.22 0.41 1.57 46.88
93 INT137143 HIVEP1 Positive_regulation of OPRM1 1 0.15 0.43 0.52 43.88
94 INT318039 CDIPT Positive_regulation of CYP3A4 1 0.06 0.06 0.2 37.72
95 INT101439 Cck Positive_regulation of Agtr2 1 0.24 0.33 0.8 31.04
96 INT214370 Slc6a3 Regulation of Amph 1 0.14 0.44 0.82 28.20
97 INT256298 Binding of Creb1 and Ephb1 1 0.16 1.27 1.22 27.80
98 INT256294 Binding of Grin2b and Ephb1 1 0.28 1.11 1.08 27.80
99 INT256297 Binding of Creb1 and Insrr 1 0.00 1.22 1.19 27.56
100 INT256293 Binding of Grin2b and Insrr 1 0.01 1.06 1.05 27.56
101 INT256295 Binding of Creb1 and Grin2b 1 0.11 1.21 1.19 26.76
102 INT121000 Binding of PAG1 and Nrm 1 0.13 0.67 1.25 25.00
103 INT257776 Phosphorylation of AR Positive_regulation of Localization of TAB2 1 0.26 0.38 0.24 12.28
104 INT259233 Binding of Oprm1 and Flna 1 0.03 0.25 25.89 5.00
105 INT259228 Binding of Oprm1 and Glul 1 0.00 0.08 7.22 5.00
106 INT259209 Binding of Glul and Flna 1 0.03 0 4.2 5.00
107 INT259230 Negative_regulation of Binding of Oprm1 and Flna 1 0.02 0 4.15 5.00
108 INT127128 Binding of CNR1 and CNR2 8 0.39 3.98 3.97 5.00
109 INT113080 Drd1a Positive_regulation of Phosphorylation of Creb1 2 0.27 0.43 3.88 5.00
110 INT302118 Binding of Oprm1 and Ppp1r9b 2 0.24 0.26 3.45 5.00
111 INT334928 Binding of pr and Aes 1 0.00 1.49 3.38 5.00
112 INT259231 Binding of Oprm1 and Ppp1r9b 1 0.01 0 2.67 5.00
113 INT259198 Oprm1 Negative_regulation of Binding of Oprm1 and Flna 1 0.00 0 2.64 5.00
114 INT259214 Oprm1 Negative_regulation of Binding of Flna and Flna 1 0.01 0 2.64 5.00
115 INT245348 Binding of Abat and Vta1 1 0.03 0.53 2.01 5.00
116 INT297488 Itpr3 Regulation of Positive_regulation of Ltp 1 0.02 0.47 1.87 5.00
117 INT297489 Ryr2 Regulation of Positive_regulation of Ltp 1 0.05 0.16 1.64 5.00
118 INT182706 NPFF Regulation of Binding of TP53INP2 1 0.01 0.07 1.52 5.00
119 INT259232 Binding of Flna and Positive_regulation of Localization of Oprm1 1 0.03 0 1.39 5.00
120 INT259211 Binding of Ppp1r9b and Flna 1 0.06 0 1.33 5.00
121 INT154518 Binding of Ephb6 and Grin2b 1 0.21 0.24 1.28 5.00
122 INT73597 Positive_regulation of BAX Positive_regulation of Casp1 1 0.06 0.69 1.28 5.00
123 INT73598 BAX Positive_regulation of Casp1 1 0.06 0.63 1.27 5.00
124 INT136257 Tff3 Regulation of SGCG 1 0.00 0.18 1.24 5.00
125 INT136255 Tff3 Regulation of GRIA1 1 0.00 0.18 1.24 5.00
126 INT136250 Phosphorylation of Tff3 Regulation of Creb1 1 0.02 0.18 1.24 5.00
127 INT259229 Positive_regulation of Binding of Oprm1 and Flna 1 0.02 0 1.23 5.00
128 INT136256 Creb1 Regulation of SGCG 1 0.26 0.18 1.23 5.00
129 INT136258 Creb1 Regulation of GRIA1 1 0.26 0.18 1.23 5.00
130 INT136249 Drd1a Positive_regulation of Phosphorylation of Tff3 1 0.01 0.18 1.23 5.00
131 INT204558 Tens1 Negative_regulation of Pdgfc 1 0.01 0.25 1.2 5.00
132 INT264988 Binding of CYP2C19 and CYP3A4 1 0.18 0.72 1.09 5.00
133 INT264987 Binding of CYP2C9 and CYP3A4 1 0.19 0.71 1.08 5.00
134 INT297491 Positive_regulation of Lta Positive_regulation of Ltp 1 0.00 0.16 1.06 5.00
135 INT245349 Binding of Abat and Gpr156 1 0.02 0.26 1 5.00
136 INT61317 Positive_regulation of Oprd1 Positive_regulation of Gene_expression of Coq10a 1 0.01 0.39 0.91 5.00
137 INT257895 Positive_regulation of Sostdc1 Positive_regulation of Positive_regulation of GRIN1 1 0.00 0.09 0.83 5.00
138 INT257896 Sostdc1 Positive_regulation of Positive_regulation of GRIN1 1 0.00 0.09 0.83 5.00
139 INT201241 Positive_regulation of GDI2 Positive_regulation of Regulation of AGFG1 1 0.01 0 0.82 5.00
140 INT245350 Abat Regulation of Dbh 1 0.00 0.37 0.8 5.00
141 INT302119 Positive_regulation of Binding of Oprm1 and Ppp1r9b 1 0.02 0 0.77 5.00
142 INT297490 Itpr3 Regulation of Ltp 1 0.02 0 0.7 5.00
143 INT73381 Npy5r Positive_regulation of Positive_regulation of Npy 1 0.12 0 0.63 5.00
144 INT159455 Binding of Vamp1 and Ppidl1 1 0.00 0.84 0.57 5.00
145 INT256296 Efnb1 Positive_regulation of Ephb1 1 0.03 0.66 0.54 5.00
146 INT297479 Ryr2 Positive_regulation of Ca2 1 0.22 0 0.52 5.00
147 INT182703 NPFF Regulation of TP53INP2 1 0.01 0 0.51 5.00
148 INT182705 NPFF Regulation of Localization of PRL 1 0.03 0 0.48 5.00
149 INT233668 Cebpd Negative_regulation of Cebpg 1 0.43 0.66 0.46 5.00
150 INT259208 Ca2 Positive_regulation of Phosphorylation of Creb1 1 0.04 0 0.45 5.00
151 INT244280 Binding of Tspo and Ptz1a 1 0.02 0.49 0.41 5.00
152 INT322995 Binding of ABCC1 and SSD 1 0.00 0.42 0.41 5.00
153 INT214374 Pik3cb Regulation of Gene_expression of Slc6a3 1 0.37 0.3 0.35 5.00
154 INT214377 Akt1 Regulation of Amph 1 0.15 0 0.33 5.00
155 INT214371 Amph Positive_regulation of Ubqln1 1 0.01 0 0.3 5.00
156 INT214373 Negative_regulation of Amph Positive_regulation of Ubqln1 1 0.01 0 0.3 5.00
157 INT159457 Binding of Vamp1 and Inadl2 1 0.00 0.36 0.29 5.00
158 INT159456 Negative_regulation of Binding of Vamp1 and Ppidl1 1 0.00 0.42 0.28 5.00
159 INT293900 TYRP1 Regulation of IGKC 1 0.01 0.11 0.27 5.00
160 INT310402 Binding of CALM1 and Grin1 1 0.00 0 0.26 5.00
161 INT44441 GNRH1 Positive_regulation of Localization of FSHR 2 0.15 0.86 0.26 5.00
162 INT214366 Ins1 Regulation of Slc6a3 1 0.11 0.09 0.25 5.00
163 INT214367 Amph Positive_regulation of Localization of Ubqln1 1 0.01 0 0.21 5.00
164 INT214376 Ubqln1 Regulation of Flvcr2 1 0.00 0 0.19 5.00
165 INT214375 Amph Regulation of Ubqln1 1 0.00 0 0.16 5.00
166 INT260363 Gopc Regulation of Oprd1 1 0.16 0.41 0.15 5.00
167 INT293901 Positive_regulation of TYRP1 Regulation of IGKC 1 0.02 0.06 0.15 5.00
168 INT232015 SERPING1 Negative_regulation of F12 2 0.24 1.19 0.12 5.00
169 INT257777 INCENP Positive_regulation of AR 1 0.04 0.49 0.08 5.00
170 INT272774 Binding of Mc4r and Fto 1 0.30 0.66 0.08 5.00
171 INT201378 Bdnf Regulation of Gene_expression of Ltp 1 0.00 0.21 0.07 5.00
172 INT342466 Binding of FFAR1 and MAFD1 1 0.03 0.87 0.05 5.00
173 INT290727 Binding of Prdm6 and Arsi 1 0.01 0.17 0.04 5.00
174 INT293899 UPF1 Positive_regulation of Gene_expression of APOB 1 0.01 0 0.04 5.00
175 INT202573 Binding of DIO2 and DRD4 1 0.07 0.09 0.03 5.00
176 INT202572 NOVA2 Regulation of DDT 1 0.03 0.14 0 5.00
177 INT202571 Binding of DRD2 and DRD4 1 0.41 0.76 0 5.00
178 INT270759 Binding of HSD11B1 and TERT 1 0.07 1.67 0 5.00
179 INT262370 Binding of GAD1 and GNPTAB 1 0.00 1.36 0 5.00
180 INT270758 GNRHR Positive_regulation of Localization of FSHR 1 0.08 0.68 0 5.00
181 INT281402 Binding of AGRP and RAPGEFL1 1 0.05 0.29 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Opiate Addiction. They are ordered first by their pain relevance and then by number of times they were reported in Opiate Addiction. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 100.00
2 INT18522 Positive_regulation of Gene_expression of IFNA1 248 0.67 160.85 44.87 100.00
3 INT300099 Positive_regulation of Gene_expression of PIAS3 1 0.10 4.23 0.04 100.00
4 INT5591 Regulation of Gene_expression of Fos 425 0.62 129.06 265.78 100.00
5 INT6056 Negative_regulation of Gene_expression of Fos 601 0.59 193.05 386.84 100.00
6 INT12484 Binding of Drd2 45 0.48 15.17 24.72 100.00
7 INT847 Regulation of Lhb 131 0.61 22.08 46.54 100.00
8 INT10536 Gene_expression of Trib3 67 0.66 27.08 21.58 100.00
9 INT11807 Gene_expression of Il2 266 0.78 112 64.97 100.00
10 INT728 Positive_regulation of Penk 1068 0.70 186.9 636.87 100.00
11 INT272768 Gene_expression of Nrxn3 5 0.78 4.73 3.31 100.00
12 INT4937 Negative_regulation of Oprd1 224 0.59 44.51 171.11 100.00
13 INT119525 Negative_regulation of Positive_regulation of Camk2a 14 0.43 5.15 8.45 100.00
14 INT109150 Negative_regulation of Tubgcp2 4 0.38 2.04 5.12 100.00
15 INT292 Localization of Penk 876 0.81 88.44 669.14 100.00
16 INT81885 Regulation of Gene_expression of Naa15 5 0.40 1.56 4.59 100.00
17 INT121988 Negative_regulation of Gene_expression of Camk2a 8 0.59 4.76 5.72 100.00
18 INT1617 Positive_regulation of Binding of Oprl1 10 0.59 0.63 9.79 100.00
19 INT310381 Positive_regulation of Gene_expression of Nrxn3 1 0.03 1.19 1 100.00
20 INT265696 Negative_regulation of Transcription of Oxt 2 0.39 0.57 1.11 100.00
21 INT74389 Gene_expression of Gdnf 131 0.78 58.52 57.06 100.00
22 INT92001 Regulation of Gene_expression of Gdnf 12 0.62 6.62 6.65 100.00
23 INT40486 Positive_regulation of Positive_regulation of ADCY1 20 0.48 4.29 11.33 100.00
24 INT27694 Positive_regulation of Positive_regulation of ADRA1D 10 0.70 1.52 3.57 100.00
25 INT49712 Regulation of Nr3c1 10 0.28 5.65 4.06 100.00
26 INT24619 Regulation of Thop1 11 0.44 1.24 4.5 100.00
27 INT119606 Regulation of Gene_expression of LEP 17 0.45 17.96 3.75 100.00
28 INT130466 Regulation of Negative_regulation of Tubgcp2 2 0.30 0.55 1.24 100.00
29 INT22946 Gene_expression of MBD2 4 0.25 0.26 0.98 100.00
30 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 99.98
31 INT5202 Positive_regulation of Gene_expression of Fos 1163 0.70 319.28 684 99.98
32 INT7114 Positive_regulation of Ltp 1192 0.62 290.76 755.77 99.98
33 INT5380 Positive_regulation of Gene_expression of Fos 243 0.70 105.65 131.05 99.98
34 INT11012 Positive_regulation of Creb1 258 0.70 84.4 132 99.98
35 INT65078 Negative_regulation of Pnoc 64 0.59 15.48 59.81 99.98
36 INT84496 Regulation of Positive_regulation of Ephb1 18 0.61 10.16 13.92 99.98
37 INT48929 Regulation of Ephb1 71 0.62 24.42 42.11 99.98
38 INT134147 Positive_regulation of Gene_expression of FADD 2 0.59 1.59 1.31 99.98
39 INT102512 Gene_expression of B3galt6 10 0.52 3.01 8.25 99.96
40 INT102508 Positive_regulation of Gene_expression of B3galt6 1 0.47 1.02 4.64 99.96
41 INT102510 Negative_regulation of Gene_expression of B3galt6 1 0.29 0.58 2.11 99.96
42 INT2838 Positive_regulation of Gene_expression of Oxt 27 0.67 6.25 6.83 99.96
43 INT5895 Gene_expression of Oprm1 525 0.78 120.67 407.29 99.92
44 INT5540 Positive_regulation of Oprm1 344 0.70 76.77 319.71 99.92
45 INT5906 Negative_regulation of Oprm1 125 0.59 19.58 101.57 99.92
46 INT724 Negative_regulation of Alb 151 0.59 93.57 29.65 99.92
47 INT88081 Negative_regulation of Gene_expression of Oprm1 45 0.59 16.56 37.5 99.92
48 INT48769 Regulation of Pdpk1 20 0.35 9.78 20.36 99.90
49 INT4941 Positive_regulation of Oprd1 345 0.70 74.26 304.41 99.88
50 INT57178 Regulation of REG1A 4 0.38 1.77 1.34 99.88
51 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 99.86
52 INT738 Regulation of POMC 459 0.62 111.19 243.74 99.86
53 INT20976 Binding of CRYGS 39 0.46 5.4 20.09 99.86
54 INT6934 Binding of OPRD1 51 0.48 7.72 25.73 99.84
55 INT300092 Regulation of SOCS3 1 0.08 3.03 0.03 99.84
56 INT300105 Regulation of PIAS3 1 0.06 3.02 0.03 99.84
57 INT54368 Positive_regulation of VTA1 13 0.59 3.81 8.13 99.84
58 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02 99.82
59 INT81884 Gene_expression of Naa15 16 0.50 5.47 17.77 99.82
60 INT49569 Regulation of PTGDR 2 0.50 1.38 2.03 99.82
61 INT7627 Negative_regulation of Positive_regulation of Ltp 162 0.50 41.2 106.27 99.80
62 INT16396 Negative_regulation of CEBPZ 76 0.48 30.03 21.6 99.80
63 INT5711 Positive_regulation of Localization of Lhb 90 0.70 10.92 36.76 99.80
64 INT5379 Gene_expression of Fos 656 0.78 255.5 292.54 99.78
65 INT5660 Binding of Oprd1 477 0.48 71.86 342.06 99.76
66 INT22145 Binding of Sugt1 16 0.13 8.31 4.37 99.76
67 INT4658 Binding of OPRM1 188 0.48 25.96 136.24 99.76
68 INT2366 Binding of Cck 192 0.48 30.64 163.46 99.76
69 INT6042 Binding of Oprm1 248 0.48 31.77 154.34 99.76
70 INT109095 Binding of Drd4 7 0.40 3.6 3.18 99.76
71 INT927 Gene_expression of Oxt 184 0.78 44.71 35.79 99.76
72 INT24011 Binding of Drd3 13 0.47 3.03 4.64 99.76
73 INT1352 Localization of Acot1 728 0.80 73.01 296.01 99.72
74 INT1353 Negative_regulation of Localization of Acot1 153 0.53 15.05 75.17 99.72
75 INT136536 Regulation of Nrgn 5 0.61 0.37 3.9 99.72
76 INT123554 Transcription of Dbi 5 0.72 1.13 1.13 99.72
77 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 99.70
78 INT86998 Regulation of HIVEP1 49 0.44 37.83 4 99.70
79 INT3300 Positive_regulation of Gene_expression of Calca 179 0.70 77.76 144.2 99.70
80 INT4740 Gene_expression of Th 298 0.78 61.27 154.03 99.68
81 INT7956 Regulation of Gene_expression of Th 44 0.61 8.26 29.31 99.68
82 INT4860 Positive_regulation of CALCA 148 0.00 73.35 97.61 99.68
83 INT8840 Positive_regulation of Positive_regulation of CALCA 8 0.50 1.8 2.74 99.68
84 INT60252 Binding of HIVEP1 59 0.32 65.12 5.06 99.66
85 INT150422 Positive_regulation of Aes 24 0.43 15.63 8 99.66
86 INT134148 Gene_expression of FADD 4 0.66 3.35 1.54 99.66
87 INT125244 Gene_expression of Ril2 4 0.30 1.9 0.87 99.64
88 INT103666 Regulation of Mors1 20 0.28 3.6 18.86 99.64
89 INT167270 Negative_regulation of Gene_expression of Lep 13 0.55 5.48 1.19 99.64
90 INT5127 Localization of Lhb 488 0.80 50.48 162.66 99.62
91 INT95565 Positive_regulation of IL12A 47 0.56 33.96 10.16 99.60
92 INT300107 Positive_regulation of Gene_expression of SOCS3 1 0.15 3.58 0.05 99.60
93 INT135443 Phosphorylation of Map2k1 11 0.80 2.44 8.01 99.60
94 INT1212 Binding of Oprl1 312 0.48 28.6 225.15 99.60
95 INT109219 Negative_regulation of Cdk5r1 5 0.43 1.22 4.25 99.60
96 INT109223 Negative_regulation of Cdk5 14 0.59 3.27 12.73 99.60
97 INT300106 Negative_regulation of Gene_expression of SOAT1 1 0.06 0.8 0 99.60
98 INT107129 Positive_regulation of RLS 46 0.60 40.1 8.09 99.60
99 INT88020 Positive_regulation of Fas 32 0.70 19.78 9.97 99.58
100 INT88014 Positive_regulation of Gene_expression of Fas 29 0.50 14.84 7.47 99.58
101 INT29105 Positive_regulation of OPRK1 68 0.70 7.06 44.69 99.58
102 INT7845 Regulation of OPRK1 44 0.62 4.54 30.49 99.58
103 INT113514 Positive_regulation of Eif2s1 2 0.49 0.85 1.46 99.58
104 INT8775 Binding of IGHE 167 0.48 102.61 23.54 99.58
105 INT22004 Positive_regulation of Binding of IGHE 7 0.49 3.29 0.96 99.58
106 INT146299 Regulation of NRXN3 1 0.45 0.34 0.48 99.58
107 INT88617 Positive_regulation of Gene_expression of Creb1 90 0.69 51.69 44.29 99.56
108 INT52651 Positive_regulation of Prkaca 136 0.67 40.82 99.16 99.56
109 INT16631 Negative_regulation of APC 46 0.57 30.53 7.11 99.56
110 INT127016 Regulation of Grk4 3 0.60 2.59 1 99.56
111 INT28510 Positive_regulation of Gpi 21 0.68 6.75 14.27 99.54
112 INT18992 Negative_regulation of Pdpk1 53 0.42 19.02 40.95 99.54
113 INT91913 Regulation of GRIN3B 16 0.61 11.48 14.44 99.52
114 INT3579 Localization of Oxt 555 0.81 43.35 292.44 99.52
115 INT166337 Regulation of Gene_expression of GRIN2D 1 0.37 0.33 1.25 99.52
116 INT166342 Regulation of Gene_expression of GRIN3B 1 0.45 0.33 1.25 99.52
117 INT62725 Regulation of GRIN2D 6 0.45 2.98 5.68 99.52
118 INT88908 Positive_regulation of Localization of Dnm1 1 0.45 0.33 1.08 99.52
119 INT88907 Localization of Dnm1 2 0.81 1 1.08 99.52
120 INT114 Binding of Oprl1 139 0.48 23 103.35 99.50
121 INT7113 Negative_regulation of Localization of CGA 71 0.51 17.7 23.42 99.50
122 INT1642 Negative_regulation of Localization of PLOD1 40 0.58 10.67 17.95 99.50
123 INT300090 Gene_expression of PIAS3 1 0.17 11.36 0.13 99.48
124 INT300100 Positive_regulation of PIAS3 1 0.15 8.51 0.09 99.48
125 INT9821 Binding of Bcl2a1a 9 0.33 4.32 3.47 99.48
126 INT25831 Gene_expression of NR4A2 20 0.74 2.73 4.92 99.48
127 INT148259 Negative_regulation of Gene_expression of NR4A2 2 0.55 0.71 0.91 99.48
128 INT159423 Binding of ANKK1 4 0.47 0.9 1.35 99.48
129 INT89963 Regulation of Fas 15 0.59 8.25 4.32 99.46
130 INT139177 Regulation of Fadd 1 0.60 0.78 1.69 99.46
131 INT66005 Regulation of Cnr1 47 0.61 19.21 34.52 99.44
132 INT14701 Negative_regulation of IFNA1 118 0.54 84.19 20.08 99.42
133 INT1562 Localization of Crh 499 0.81 126.74 236.68 99.42
134 INT477 Localization of Avp 813 0.81 131.58 300.4 99.42
135 INT4358 Positive_regulation of Localization of Avp 195 0.70 30.79 77.58 99.42
136 INT5509 Positive_regulation of Localization of Crh 91 0.70 30.65 53.92 99.42
137 INT6058 Localization of Fos 73 0.81 16.7 30.84 99.42
138 INT48605 Positive_regulation of Localization of Fos 4 0.49 1.26 2.94 99.42
139 INT43572 Binding of PCDHB17 2 0.04 0.35 1.33 99.42
140 INT53638 Binding of IGHD2-15 1 0.05 0.35 0.65 99.42
141 INT5058 Positive_regulation of IFNA1 356 0.70 245.75 60.52 99.40
142 INT74151 Gene_expression of EME1 1 0.31 0.1 0.7 99.40
143 INT300095 Regulation of Gene_expression of PIAS1 1 0.10 1.59 0 99.38
144 INT97623 Negative_regulation of Adc 17 0.56 3.81 8.14 99.38
145 INT116536 Binding of GRK6 1 0.31 0.3 1.19 99.38
146 INT116537 Binding of ARRB2 1 0.34 0.3 1.19 99.38
147 INT179884 Gene_expression of SOCS3 10 0.67 16.57 1.14 99.36
148 INT9476 Regulation of Gene_expression of Jun 14 0.43 4.25 7.61 99.36
149 INT179887 Positive_regulation of SOCS3 10 0.50 13.06 0.45 99.34
150 INT39459 Gene_expression of SOAT1 10 0.75 7.62 1.52 99.34
151 INT279298 Gene_expression of JAK1 7 0.65 5.5 0.37 99.34
152 INT61624 Positive_regulation of Gene_expression of IL12A 50 0.56 33.07 13.07 99.34
153 INT300091 Positive_regulation of Negative_regulation of PIAS3 1 0.11 1.76 0 99.34
154 INT300103 Positive_regulation of Negative_regulation of SOCS3 1 0.15 1.75 0 99.34
155 INT1793 Localization of CGA 379 0.81 67.38 114.69 99.34
156 INT1599 Positive_regulation of ADCY1 146 0.67 30.05 64.9 99.32
157 INT6699 Positive_regulation of ADRA1D 65 0.70 22.72 20.31 99.32
158 INT79479 Positive_regulation of Gene_expression of Sp7 1 0.61 0.16 1.53 99.32
159 INT101483 Gene_expression of Lep 159 0.78 104.77 25.12 99.30
160 INT26472 Regulation of Oprm1 191 0.62 35.84 173.1 99.28
161 INT937 Positive_regulation of Oxt 195 0.70 37.82 49.3 99.28
162 INT13716 Positive_regulation of TH 33 0.68 19.11 16 99.28
163 INT148266 Positive_regulation of SNCA 5 0.67 3.17 1.74 99.28
164 INT101482 Negative_regulation of Lep 53 0.54 33.59 5.65 99.28
165 INT17881 Gene_expression of LEP 278 0.78 221.61 48.31 99.28
166 INT26069 Positive_regulation of Positive_regulation of IFNA1 26 0.50 16.61 4.76 99.26
167 INT56032 Positive_regulation of NCAM1 38 0.49 26.01 4.68 99.24
168 INT16258 Gene_expression of Ntf3 121 0.78 53.93 59.03 99.24
169 INT4208 Regulation of Got1 23 0.44 6.72 6.62 99.24
170 INT92662 Negative_regulation of Gene_expression of Ntf3 9 0.57 7.44 6.22 99.24
171 INT5228 Positive_regulation of Fos 934 0.70 209.8 503.87 99.20
172 INT300102 Gene_expression of TYK2 1 0.29 2.34 0.05 99.20
173 INT10304 Binding of OPRK1 89 0.48 9.28 49.42 99.20
174 INT80521 Negative_regulation of Binding of OPRK1 4 0.43 0.8 2.93 99.20
175 INT695 Binding of POMC 304 0.48 56.66 126.85 99.20
176 INT25031 Negative_regulation of Gene_expression of PLOD1 14 0.54 3.86 2.89 99.20
177 INT989 Negative_regulation of Trh 90 0.59 15.45 43.63 99.20
178 INT6406 Binding of Oprm1 280 0.48 40.54 226.26 99.16
179 INT13501 Binding of Drd2 65 0.48 23.76 35.6 99.16
180 INT1395 Negative_regulation of Penk 537 0.59 87.33 389.81 99.16
181 INT30245 Binding of Pdyn 26 0.37 2.31 17 99.16
182 INT79093 Positive_regulation of Nos1 101 0.70 46.89 59.61 99.16
183 INT24820 Positive_regulation of Binding of POMC 9 0.67 2.98 4.6 99.16
184 INT9484 Gene_expression of Jun 175 0.78 34.89 68.54 99.14
185 INT135444 Regulation of Map2k1 4 0.44 1.15 1.77 99.14
186 INT77252 Gene_expression of Nr3c1 17 0.67 9.71 5.38 99.14
187 INT17592 Positive_regulation of Regulation of Fos 21 0.67 3.54 10.07 99.14
188 INT5852 Gene_expression of Penk 167 0.78 44.44 71.13 99.12
189 INT153417 Gene_expression of DDOST 6 0.67 1.81 2.18 99.12
190 INT268737 Positive_regulation of Gene_expression of DDOST 2 0.44 0.58 0.89 99.12
191 INT21344 Negative_regulation of Penk 34 0.57 8.83 23.32 99.12
192 INT61619 Gene_expression of IL12A 194 0.77 146.07 41.97 99.10
193 INT238201 Gene_expression of JAK2 9 0.70 7.09 0.81 99.10
194 INT5497 Positive_regulation of Crh 299 0.70 125.54 131.14 99.08
195 INT8480 Gene_expression of PIAS1 3 0.78 1.73 1.57 99.08
196 INT2451 Positive_regulation of Avp 355 0.70 102.66 147.69 99.08
197 INT11062 Positive_regulation of MME 24 0.63 14.37 5.26 99.08
198 INT80447 Negative_regulation of ARRB2 5 0.39 3.12 6.3 99.06
199 INT116538 Negative_regulation of GRK6 1 0.48 0.84 3.31 99.06
200 INT102509 Negative_regulation of Vta1 5 0.29 0.87 5.62 99.06
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