D:Oral Herpes Simplex

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Disease Term
Synonyms COLD SORES, Gingivostomatitides Herpetic, Gingivostomatitis Herpetic, Herpes Simplex Oral, HERPETIC GINGIVOSTOMATITIDES, Herpetic Gingivostomatitis, Herpetic Stomatitides, Herpetic Stomatitis, Simplex Oral Herpes, Stomatitides Herpetic, Stomatitis Herpetic
Documents 23
Hot Single Events 0
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Oral Herpes Simplex. They are ordered first by their relevance to Oral Herpes Simplex and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT149117 Binding of CD80 and CTLA4 31 0.52 12.7 7.73 5.00
2 INT155484 Binding of CD86 and CTLA4 15 0.52 8.85 6.09 5.00
3 INT186393 Binding of TNF and Tnfrsf1a 9 0.37 8.55 1.29 5.00
4 INT186355 Il23a Positive_regulation of Gene_expression of Il17a 4 0.12 3 1.24 5.00
5 INT186373 Il6 Positive_regulation of Gene_expression of Il17a 2 0.14 1.52 0.42 5.00
6 INT186385 Binding of TNF and Tnfrsf1b 4 0.30 3.24 0.42 5.00
7 INT186345 Binding of Gast and Stat6 1 0.03 2.19 0.3 5.00
8 INT186368 Il10 Negative_regulation of Gene_expression of Il12a 1 0.06 0.17 0.24 5.00
9 INT186374 Il13 Negative_regulation of Positive_regulation of Il12a 1 0.06 0.3 0.23 5.00
10 INT186371 Il4 Negative_regulation of Positive_regulation of Il12a 1 0.06 0.3 0.23 5.00
11 INT186351 Binding of Gast and Stat1 3 0.16 2.77 0.22 5.00
12 INT186391 TNF Positive_regulation of Gene_expression of Il17a 1 0.03 0.38 0.22 5.00
13 INT186358 Il1 Positive_regulation of Gene_expression of Il17a 1 0.02 0.38 0.22 5.00
14 INT186353 Binding of Il12a and Il1 1 0.21 0.38 0.2 5.00
15 INT186380 Binding of SOAT1 and Stat6 1 0.02 0.11 0.15 5.00
16 INT186357 Binding of Irf1 and Stat6 1 0.04 2.09 0.14 5.00
17 INT186372 Binding of Irf1 and Stat1 1 0.04 2.06 0.14 5.00
18 INT186379 Il12a Positive_regulation of Binding of IFNA1 1 0.03 0.07 0.12 5.00
19 INT186369 Negative_regulation of Binding of Gast and Stat1 1 0.04 1.04 0.07 5.00
20 INT186347 Binding of Irf2 and Rfc1 1 0.00 1.02 0.07 5.00
21 INT186361 Binding of Gast and Irf1 1 0.01 1.03 0.07 5.00
22 INT186364 Binding of Irf2 and Nos2 1 0.04 1.02 0.07 5.00
23 INT186341 Binding of Irf1 and Irf2 1 0.02 1.04 0.07 5.00
24 INT186366 Binding of Stat1 and Stat6 1 0.12 1.04 0.07 5.00
25 INT186375 TNF Negative_regulation of Gene_expression of Il12b 1 0.03 0.78 0.06 5.00
26 INT186390 Binding of TNF and Irf1 1 0.02 0.99 0.05 5.00
27 INT186263 Binding of TNF and GORASP1 1 0.10 0.99 0.05 5.00
28 INT186383 Binding of Nos2 and GORASP1 1 0.12 0.93 0.05 5.00
29 INT186377 Binding of Irf1 and GORASP1 1 0.12 0.87 0.05 5.00
30 INT186350 Gtf3a Negative_regulation of Transcription of Nos2 1 0.00 0.77 0.04 5.00
31 INT186352 Il13 Negative_regulation of Transcription of Nos2 1 0.05 0.76 0.04 5.00
32 INT186359 Stat6 Negative_regulation of Il4 1 0.06 0.78 0.04 5.00
33 INT186362 Il4 Negative_regulation of Transcription of Nos2 1 0.04 0.77 0.04 5.00
34 INT186356 Gtf3a Regulation of Positive_regulation of Nos2 1 0.00 0.91 0.04 5.00
35 INT186360 Stat6 Negative_regulation of Transcription of Nos2 1 0.08 0.78 0.04 5.00
36 INT186348 Irf1 Regulation of Positive_regulation of Nos2 1 0.02 0.91 0.04 5.00
37 INT186387 IFNA1 Positive_regulation of Transcription of Nos2 1 0.03 0.7 0.04 5.00
38 INT186382 TNF Regulation of Il12a 1 0.06 0.72 0.03 5.00
39 INT186363 Binding of Stat6 and Positive_regulation of Positive_regulation of Irf2 1 0.05 0.4 0.03 5.00
40 INT186384 Il4 Negative_regulation of Gene_expression of IFNA1 1 0.01 0.48 0.03 5.00
41 INT186342 Il13 Negative_regulation of Positive_regulation of Nos2 1 0.03 0.65 0.03 5.00
42 INT186386 Il12a Regulation of Gene_expression of TNF 1 0.06 0.66 0.03 5.00
43 INT186354 Stat6 Positive_regulation of Positive_regulation of Irf2 1 0.06 0.4 0.03 5.00
44 INT186344 Binding of Tnfrsf1a and Tnfrsf1b 1 0.20 0.48 0 5.00
45 INT186378 IFNA1 Positive_regulation of Il12a 1 0.03 0.76 0 5.00
46 INT186346 Binding of Irf8 and Irf1 1 0.05 1.25 0 5.00
47 INT186392 Binding of TNF and P4hb 1 0.02 0.47 0 5.00
48 INT186343 Irf1 Positive_regulation of Nos2 1 0.04 0.83 0 5.00
49 INT186381 TNF Positive_regulation of Nos2 1 0.04 1.17 0 5.00
50 INT186388 Binding of IFNA1 and Ifnz 1 0.05 0.51 0 5.00
51 INT186376 IFNA1 Positive_regulation of Il18 1 0.02 0.76 0 5.00
52 INT186365 Vcam1 Regulation of Binding of Irf1 1 0.05 0.83 0 5.00
53 INT186370 Regulation of Binding of Irf8 and Irf1 1 0.04 0.82 0 5.00
54 INT186389 IFNA1 Regulation of Positive_regulation of Nos2 1 0.02 1.38 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Oral Herpes Simplex. They are ordered first by their pain relevance and then by number of times they were reported in Oral Herpes Simplex. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT197721 Positive_regulation of ARMC9 36 0.35 20.08 1.03 19.36
2 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
3 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
4 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
5 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
6 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
7 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
8 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 5.00
9 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
10 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
11 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 5.00
12 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 5.00
13 INT66280 Gene_expression of Nos2 534 0.78 330.78 157.07 5.00
14 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
15 INT62124 Gene_expression of NOS1 444 0.78 218.08 114.85 5.00
16 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 5.00
17 INT20374 Gene_expression of Il4 515 0.76 306.15 114.12 5.00
18 INT118381 Gene_expression of Il17a 405 0.76 306.97 112.06 5.00
19 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 5.00
20 INT12082 Localization of IL6 365 0.81 241.78 105.78 5.00
21 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 5.00
22 INT77435 Positive_regulation of Nos2 343 0.70 208.49 91.43 5.00
23 INT56291 Gene_expression of Ros1 503 0.63 274.12 81.5 5.00
24 INT60691 Gene_expression of Il12a 331 0.78 208.03 75.96 5.00
25 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 5.00
26 INT11380 Negative_regulation of IL1B 215 0.59 125.62 72.35 5.00
27 INT6849 Localization of IL1B 229 0.81 112.56 69.63 5.00
28 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 5.00
29 INT9657 Positive_regulation of Gene_expression of Il6 237 0.70 180.45 63.6 5.00
30 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 5.00
31 INT5058 Positive_regulation of IFNA1 356 0.70 245.75 60.52 5.00
32 INT19775 Localization of Il1 183 0.78 145.5 50.91 5.00
33 INT9210 Regulation of IL6 166 0.62 125.61 49.95 5.00
34 INT18522 Positive_regulation of Gene_expression of IFNA1 248 0.67 160.85 44.87 5.00
35 INT100939 Gene_expression of Il13 176 0.73 125.1 43.38 5.00
36 INT52531 Gene_expression of Nfkb1 153 0.75 82.84 42.9 5.00
37 INT85943 Negative_regulation of Nos2 161 0.59 108.56 42.65 5.00
38 INT5973 Regulation of IL1B 109 0.62 66.6 39.88 5.00
39 INT6302 Binding of IFNA1 196 0.48 133.85 32.73 5.00
40 INT92837 Negative_regulation of Gene_expression of Nos2 116 0.59 59.67 31.82 5.00
41 INT13186 Positive_regulation of Il4 113 0.68 71.22 31.4 5.00
42 INT54302 Positive_regulation of Gene_expression of Il4 126 0.68 86.18 30.75 5.00
43 INT16428 Positive_regulation of Gtf3a 135 0.20 106.44 26.67 5.00
44 INT135411 Gene_expression of Il23a 76 0.72 72.87 26.15 5.00
45 INT55583 Localization of IFNA1 135 0.78 85.07 24.13 5.00
46 INT93738 Gene_expression of Tnfrsf1a 63 0.74 57.66 23.09 5.00
47 INT14700 Regulation of IFNA1 111 0.45 66.16 21.52 5.00
48 INT60690 Positive_regulation of Gene_expression of Il12a 69 0.63 41.41 20.85 5.00
49 INT66281 Transcription of Nos2 81 0.71 39.49 20.37 5.00
50 INT14701 Negative_regulation of IFNA1 118 0.54 84.19 20.08 5.00
51 INT88949 Positive_regulation of Il12a 79 0.60 47.68 19.98 5.00
52 INT7994 Gene_expression of Lta 113 0.67 69.81 19.59 5.00
53 INT93948 Negative_regulation of Gene_expression of Il12a 48 0.55 27.77 16.87 5.00
54 INT77433 Regulation of Gene_expression of Nos2 49 0.62 35.07 16.33 5.00
55 INT170335 Gene_expression of INCENP 176 0.54 91.62 15.31 5.00
56 INT100938 Positive_regulation of Il13 47 0.69 42.11 14.36 5.00
57 INT78472 Gene_expression of CDKN2A 223 0.78 173.76 13.61 5.00
58 INT69878 Positive_regulation of Gene_expression of Gtf3a 48 0.29 36.78 13.57 5.00
59 INT87235 Negative_regulation of Il4 54 0.48 31.51 13.15 5.00
60 INT54763 Binding of Il6 82 0.48 63.27 12.89 5.00
61 INT195226 Positive_regulation of ACR 23 0.26 7.85 12.62 5.00
62 INT31990 Positive_regulation of SOD1 124 0.69 67.79 12.52 5.00
63 INT90909 Negative_regulation of Gene_expression of NOS1 44 0.55 23.83 12.47 5.00
64 INT178338 Gene_expression of Tbx15 50 0.65 38.65 12.19 5.00
65 INT97381 Negative_regulation of Positive_regulation of Nos2 34 0.59 16.66 11.6 5.00
66 INT133172 Gene_expression of Il12b 98 0.75 52.16 10.68 5.00
67 INT107307 Transcription of IFNA1 30 0.52 18.16 9.61 5.00
68 INT71878 Protein_catabolism of Nfkb1 24 0.65 10.85 9.46 5.00
69 INT87193 Gene_expression of Tnfrsf1b 30 0.58 29.4 9.22 5.00
70 INT186273 Negative_regulation of Il13 33 0.46 22.88 8.65 5.00
71 INT79693 Regulation of Il4 30 0.51 21.96 8.6 5.00
72 INT64815 Binding of Jun 49 0.48 21.47 8.59 5.00
73 INT116605 Binding of Nos2 28 0.37 16.88 8.18 5.00
74 INT62400 Positive_regulation of Localization of Il1 34 0.67 35.53 7.96 5.00
75 INT86411 Negative_regulation of Negative_regulation of TNF 24 0.42 17.6 7.89 5.00
76 INT112191 Positive_regulation of Transcription of Nos2 22 0.66 12.4 7.74 5.00
77 INT85751 Positive_regulation of Positive_regulation of Nos2 40 0.60 23.53 7.72 5.00
78 INT138922 Positive_regulation of Stat1 57 0.69 28.35 7.2 5.00
79 INT8793 Gene_expression of H2 58 0.75 26.36 7.07 5.00
80 INT77945 Regulation of Gene_expression of Il12a 19 0.58 6.55 6.4 5.00
81 INT150023 Positive_regulation of Il23a 25 0.38 18.33 6.32 5.00
82 INT69985 Positive_regulation of Negative_regulation of TNF 21 0.50 13.26 6.31 5.00
83 INT163756 Phosphorylation of Stat1 45 0.82 14.51 6.11 5.00
84 INT139329 Phosphorylation of IFNA1 24 0.79 16.19 5.95 5.00
85 INT124705 Binding of Il18 29 0.47 19.02 5.59 5.00
86 INT125467 Positive_regulation of Gene_expression of CDKN2A 35 0.63 39.07 5.56 5.00
87 INT24886 Negative_regulation of SFTPA1 11 0.12 4.35 5.03 5.00
88 INT26069 Positive_regulation of Positive_regulation of IFNA1 26 0.50 16.61 4.76 5.00
89 INT55171 Gene_expression of RELA 80 0.75 17.17 4.47 5.00
90 INT1209 Binding of Kitl 14 0.37 6.72 4.3 5.00
91 INT186270 Regulation of Il13 13 0.43 11.58 4.19 5.00
92 INT172173 Protein_catabolism of TNF 16 0.96 9.95 3.79 5.00
93 INT133169 Positive_regulation of Il12b 25 0.49 13 3.64 5.00
94 INT70919 Binding of Il4 19 0.36 6.58 3.59 5.00
95 INT32905 Gene_expression of Mrc1 18 0.58 11.07 3.54 5.00
96 INT174160 Binding of Il12a 19 0.24 12.61 3.4 5.00
97 INT97438 Transcription of Il4 17 0.67 9.17 3.4 5.00
98 INT163269 Binding of Il23a 11 0.44 7.2 3.14 5.00
99 INT71877 Positive_regulation of Protein_catabolism of Nfkb1 9 0.24 2.73 3.06 5.00
100 INT133174 Positive_regulation of Gene_expression of Il12b 29 0.15 13.04 2.92 5.00
101 INT172177 Protein_catabolism of INCENP 18 0.37 6.34 2.91 5.00
102 INT85750 Regulation of Positive_regulation of Nos2 10 0.54 7.78 2.83 5.00
103 INT114181 Negative_regulation of Positive_regulation of Il12a 7 0.34 3.65 2.82 5.00
104 INT49454 Negative_regulation of Gene_expression of Gtf3a 13 0.08 9.99 2.43 5.00
105 INT38118 Negative_regulation of Positive_regulation of IFNA1 8 0.43 3.95 2.04 5.00
106 INT92056 Transcription of Il12b 8 0.69 4.75 1.95 5.00
107 INT129240 Positive_regulation of Stat6 6 0.67 1.96 1.92 5.00
108 INT126906 Positive_regulation of Gene_expression of H2 12 0.21 9.2 1.91 5.00
109 INT170605 Gene_expression of RELB 12 0.65 8 1.7 5.00
110 INT186269 Binding of Il13 9 0.39 7.7 1.64 5.00
111 INT183402 Positive_regulation of Gene_expression of Tbx15 7 0.49 4.87 1.62 5.00
112 INT186286 Phosphorylation of Stat6 18 0.79 5.07 1.61 5.00
113 INT122888 Positive_regulation of Transcription of IFNA1 5 0.45 3.51 1.59 5.00
114 INT153714 Gene_expression of Tnfrsf14 5 0.65 6.56 1.58 5.00
115 INT186309 Binding of Stat1 18 0.48 5.31 1.58 5.00
116 INT93735 Gene_expression of P4hb 6 0.49 4.63 1.39 5.00
117 INT186268 Positive_regulation of Tdo2 13 0.50 8 1.32 5.00
118 INT60741 Regulation of Positive_regulation of IFNA1 9 0.16 6.98 1.24 5.00
119 INT92055 Positive_regulation of Transcription of Il12b 4 0.49 2.77 1.16 5.00
120 INT79115 Binding of Tap1 12 0.47 4.21 0.95 5.00
121 INT156227 Gene_expression of Tnfsf14 3 0.65 3.12 0.9 5.00
122 INT184027 Phosphorylation of Jak2 6 0.82 2.58 0.87 5.00
123 INT186271 Binding of Hbb-ar 3 0.47 2.66 0.79 5.00
124 INT186284 Binding of Il27 3 0.16 1.85 0.78 5.00
125 INT186283 Negative_regulation of Gene_expression of Il12b 2 0.13 7.92 0.74 5.00
126 INT174553 Localization of Stat1 17 0.80 6.62 0.73 5.00
127 INT186276 Phosphorylation of Jak1 4 0.58 0.65 0.68 5.00
128 INT69880 Positive_regulation of Positive_regulation of Gtf3a 8 0.03 5.25 0.68 5.00
129 INT186266 Gene_expression of Irf1 4 0.36 3.26 0.64 5.00
130 INT186299 Negative_regulation of Stat6 6 0.42 3.61 0.62 5.00
131 INT93002 Binding of GORASP1 2 0.36 2.81 0.59 5.00
132 INT186292 Positive_regulation of Negative_regulation of Il4 3 0.14 1.57 0.58 5.00
133 INT186277 Binding of Il12b 4 0.20 2.15 0.55 5.00
134 INT184036 Positive_regulation of Jak1 5 0.45 2.25 0.55 5.00
135 INT114293 Binding of Stat6 2 0.44 1.29 0.5 5.00
136 INT186290 Binding of Pvrl1 8 0.11 4.82 0.46 5.00
137 INT186279 Negative_regulation of Binding of Stat1 3 0.42 0.96 0.45 5.00
138 INT186288 Negative_regulation of Binding of Nos2 3 0.35 1.08 0.42 5.00
139 INT186265 Positive_regulation of Negative_regulation of Il13 2 0.16 1.35 0.37 5.00
140 INT186272 Positive_regulation of Positive_regulation of Il12a 7 0.26 4.45 0.36 5.00
141 INT18963 Gene_expression of Fcr 4 0.10 2.12 0.33 5.00
142 INT186295 Transcription of Il13 1 0.16 0.34 0.31 5.00
143 INT186278 Binding of Irf1 7 0.16 3.99 0.19 5.00
144 INT186305 Positive_regulation of Gene_expression of Irf1 2 0.17 1.24 0.18 5.00
145 INT186274 Positive_regulation of Binding of Il18 1 0.16 0 0.14 5.00
146 INT46878 Positive_regulation of Rnasel 3 0.27 2.13 0.1 5.00
147 INT186289 Negative_regulation of Gene_expression of Irf1 1 0.10 0.99 0.07 5.00
148 INT186310 Positive_regulation of Binding of Il12b 1 0.15 1.07 0.07 5.00
149 INT165418 Binding of P4hb 13 0.30 4.9 0.07 5.00
150 INT186303 Transcription of Irf1 1 0.16 0.92 0.04 5.00
151 INT186300 Binding of Irf2 1 0.08 0.98 0.03 5.00
152 INT186275 Gene_expression of Irf2 1 0.14 0.42 0.03 5.00
153 INT186280 Positive_regulation of Irf1 1 0.11 0.43 0.03 5.00
154 INT186264 Positive_regulation of Irf2 1 0.14 0.62 0.03 5.00
155 INT186307 Positive_regulation of Gene_expression of Irf2 1 0.10 0.42 0.03 5.00
156 INT186294 Negative_regulation of Positive_regulation of Irf2 1 0.09 0.23 0 5.00
157 INT186329 Protein_catabolism of RELB 1 0.86 0.55 0 5.00
158 INT186338 Gene_expression of GORASP1 1 0.65 1.76 0 5.00
159 INT186308 Positive_regulation of Lats1 1 0.02 0.55 0 5.00
160 INT186334 Protein_catabolism of GORASP1 1 0.38 0.55 0 5.00
161 INT186335 Protein_catabolism of RELA 2 0.86 0.71 0 5.00
162 INT186291 Localization of Irf1 1 0.17 0.83 0 5.00
163 INT186330 Positive_regulation of Protein_catabolism of RELA 1 0.49 0.55 0 5.00
164 INT186296 Binding of Irf8 1 0.21 2.72 0 5.00
165 INT186306 Binding of Pml 1 0.08 0.48 0 5.00
166 INT186333 Regulation of GORASP1 1 0.44 0.94 0 5.00
167 INT186301 Localization of Pml 1 0.18 0.43 0 5.00
168 INT186285 Localization of Adamts7 1 0.12 0.6 0 5.00
169 INT186293 Binding of Myo1e 1 0.00 0.4 0 5.00
170 INT186281 Positive_regulation of Binding of Il12a 2 0.26 2.09 0 5.00
171 INT186337 Positive_regulation of Protein_catabolism of RELB 1 0.49 0.55 0 5.00
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