D:Oral Leukoplakia

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Disease Term
Synonyms Keratosis Oral, Leukokeratoses Oral, LEUKOKERATOSIS ORAL, Leukoplakias Oral, Oral Leukokeratoses, ORAL LEUKOKERATOSIS, Oral Leukoplakias
Documents 23
Hot Single Events 8
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Oral Leukoplakia. They are ordered first by their relevance to Oral Leukoplakia and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT131130 Binding of PKD1 and Krt16 1 0.01 1 0.08 67.76
2 INT232917 Binding of KRT8 and KRT19 2 0.16 1.04 0.08 5.00
3 INT232914 Binding of KRT2 and KRT7 1 0.15 0.63 0.05 5.00
4 INT232916 Binding of KRT2 and KRT19 1 0.21 0.62 0.05 5.00
5 INT232907 Binding of KRT7 and KRT8 1 0.09 0.63 0.05 5.00
6 INT256418 PPARA Positive_regulation of NR1H4 1 0.01 1.17 0.04 5.00
7 INT232918 Binding of KRT2 and KRT8 1 0.17 0.59 0 5.00
8 INT204234 Binding of CDKN2A and TP53 1 0.43 1.27 0 5.00
9 INT232912 Binding of KRT4 and KRT13 1 0.07 0.06 0 5.00
10 INT232910 Binding of KRT12 and KRT76 1 0.39 0.2 0 5.00
11 INT232911 Binding of KRT18 and PLAT 1 0.05 1.3 0 5.00
12 INT232915 Binding of KRT8 and PLAT 1 0.04 1.3 0 5.00
13 INT232909 Binding of KRT1 and KRT9 1 0.16 0.5 0 5.00
14 INT232913 Binding of KRT3 and NBPF14 1 0.01 0.21 0 5.00
15 INT232908 Binding of KRT19 and PLAT 1 0.05 1.31 0 5.00
16 INT232906 Binding of KRT1 and KRT10 1 0.18 0.51 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Oral Leukoplakia. They are ordered first by their pain relevance and then by number of times they were reported in Oral Leukoplakia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT93879 Positive_regulation of TRERF1 2 0.61 2.09 0.64 94.48
2 INT146179 Gene_expression of KRT6A 23 0.75 9.39 0.52 94.16
3 INT86639 Gene_expression of KRT16 19 0.68 12.44 7.79 94.16
4 INT11387 Negative_regulation of PMEL 3 0.57 1.53 0.56 89.84
5 INT9095 Regulation of Gene_expression of COL7A1 24 0.57 10.55 4.88 86.64
6 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 86.64
7 INT5789 Gene_expression of PMEL 23 0.75 13.18 2.67 83.36
8 INT86024 Gene_expression of PPARA 736 0.78 497.93 91.14 82.80
9 INT91370 Phosphorylation of STAT3 123 0.82 49.25 8.42 74.52
10 INT45093 Binding of PMEL 10 0.37 4.77 0.89 60.52
11 INT111770 Regulation of PMEL 2 0.44 0.4 0.12 41.52
12 INT232977 Gene_expression of KRT77 1 0.75 3.41 0 16.40
13 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
14 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
15 INT6580 Negative_regulation of Ptgs1 929 0.59 381.53 376.26 5.00
16 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
17 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 5.00
18 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
19 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
20 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 5.00
21 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
22 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
23 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 5.00
24 INT67614 Positive_regulation of PPARA 438 0.68 293.28 63.61 5.00
25 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 5.00
26 INT50672 Positive_regulation of CPOX 205 0.44 125.93 60.06 5.00
27 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 5.00
28 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 5.00
29 INT17881 Gene_expression of LEP 278 0.78 221.61 48.31 5.00
30 INT52732 Negative_regulation of CRP 169 0.59 138.47 40.33 5.00
31 INT11560 Positive_regulation of CASP3 236 0.70 184.33 39.38 5.00
32 INT103094 Binding of PPARA 308 0.47 177.26 34.75 5.00
33 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 5.00
34 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 5.00
35 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 5.00
36 INT9682 Positive_regulation of IGF1 238 0.70 120.03 26.36 5.00
37 INT20462 Binding of ESR1 210 0.44 102.7 26.34 5.00
38 INT172458 Regulation of Gopc 155 0.53 62.57 24.86 5.00
39 INT101517 Negative_regulation of PPARA 168 0.57 112.24 21.41 5.00
40 INT28951 Negative_regulation of IGF1 133 0.59 75.77 18.9 5.00
41 INT170051 Positive_regulation of Gene_expression of Gopc 150 0.43 56.75 16.93 5.00
42 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71 5.00
43 INT19929 Negative_regulation of Positive_regulation of TNF 52 0.59 38.16 16.51 5.00
44 INT10214 Gene_expression of VIM 153 0.78 115.88 16.29 5.00
45 INT171666 Regulation of GOPC 117 0.39 40.41 15.47 5.00
46 INT103096 Regulation of PPARA 113 0.60 62.47 14.57 5.00
47 INT100139 Positive_regulation of Gene_expression of PPARA 160 0.63 97.78 14.53 5.00
48 INT94774 Regulation of CDKN2A 43 0.60 44.41 13.99 5.00
49 INT78472 Gene_expression of CDKN2A 223 0.78 173.76 13.61 5.00
50 INT53747 Positive_regulation of Cyp2e1 34 0.70 29.03 13.39 5.00
51 INT89395 Negative_regulation of AKT1 127 0.58 70.27 12.54 5.00
52 INT28952 Negative_regulation of Gene_expression of IGF1 75 0.58 41.11 12.32 5.00
53 INT48335 Negative_regulation of NOSTRIN 38 0.56 16.22 12.05 5.00
54 INT25963 Gene_expression of DES 122 0.75 98.81 11.25 5.00
55 INT83886 Negative_regulation of HMOX2 27 0.43 11.69 10.78 5.00
56 INT22132 Positive_regulation of CAT 41 0.67 18.64 10.67 5.00
57 INT173159 Localization of PPARA 96 0.74 64.55 10.26 5.00
58 INT178306 Negative_regulation of Gene_expression of Gopc 71 0.37 26.43 9.74 5.00
59 INT67612 Binding of PPARG 38 0.48 22.67 8.94 5.00
60 INT119831 Gene_expression of PTEN 55 0.75 40.37 8.57 5.00
61 INT57748 Positive_regulation of Gene_expression of TP53 85 0.69 79.55 7.49 5.00
62 INT16631 Negative_regulation of APC 46 0.57 30.53 7.11 5.00
63 INT38672 Binding of KRT20 69 0.39 48.01 6.31 5.00
64 INT137454 Gene_expression of ADIPOQ 88 0.78 85.32 6.2 5.00
65 INT19916 Gene_expression of GPHA2 18 0.48 9.78 6.04 5.00
66 INT75501 Gene_expression of CCND1 90 0.76 60.86 5.93 5.00
67 INT86025 Positive_regulation of Positive_regulation of PPARA 34 0.52 22.89 5.74 5.00
68 INT86023 Transcription of PPARA 60 0.66 25.8 5.7 5.00
69 INT38671 Positive_regulation of KRT20 62 0.53 40.17 5.6 5.00
70 INT38670 Positive_regulation of Gene_expression of KRT20 68 0.69 23.25 5.55 5.00
71 INT89794 Positive_regulation of CDKN2A 58 0.67 50.18 5.38 5.00
72 INT60585 Regulation of TP53 59 0.59 54.55 5.21 5.00
73 INT73262 Negative_regulation of BCL2 67 0.57 61.01 5.07 5.00
74 INT170854 Gene_expression of CFD 26 0.68 39.77 4.74 5.00
75 INT62684 Negative_regulation of TP53 66 0.58 66.09 4.62 5.00
76 INT8773 Gene_expression of HBG1 58 0.76 37.6 4.59 5.00
77 INT49805 Positive_regulation of MUC1 56 0.70 44.5 4.56 5.00
78 INT84686 Regulation of BAX 26 0.49 28.54 4.13 5.00
79 INT4988 Gene_expression of KRT1 64 0.77 43.4 4.12 5.00
80 INT111477 Gene_expression of KRT7 90 0.74 86.76 4.07 5.00
81 INT101857 Negative_regulation of BCL2L1 22 0.57 23.56 3.95 5.00
82 INT97126 Regulation of CASP3 9 0.40 8.15 3.6 5.00
83 INT78471 Regulation of Gene_expression of CDKN2A 13 0.45 12.52 3.28 5.00
84 INT86640 Positive_regulation of Gene_expression of KRT16 5 0.61 2.5 2.99 5.00
85 INT132575 Binding of NR1H4 57 0.20 22.06 2.82 5.00
86 INT38673 Negative_regulation of KRT20 38 0.42 22.49 2.77 5.00
87 INT27652 Gene_expression of TG 36 0.78 22.36 2.74 5.00
88 INT1922 Positive_regulation of CEACAM7 32 0.70 33.31 2.72 5.00
89 INT222961 Negative_regulation of Binding of PPARA 22 0.41 10.76 2.72 5.00
90 INT221269 Binding of BRCA1 14 0.40 31.77 2.7 5.00
91 INT90875 Negative_regulation of CCND1 31 0.42 26.22 2.66 5.00
92 INT92141 Negative_regulation of CDKN2A 53 0.57 44.23 2.48 5.00
93 INT72782 Positive_regulation of HCC 41 0.40 63.74 2.46 5.00
94 INT94002 Regulation of Lox 13 0.38 8.41 2.29 5.00
95 INT114953 Gene_expression of NR1H4 23 0.29 16.58 2.02 5.00
96 INT111143 Regulation of Gene_expression of KRT20 22 0.26 5.65 1.93 5.00
97 INT85084 Gene_expression of KRT19 66 0.73 42.56 1.82 5.00
98 INT173177 Positive_regulation of Localization of PPARA 21 0.49 12.61 1.74 5.00
99 INT233010 Gene_expression of PERP 5 0.26 6.04 1.66 5.00
100 INT167085 Negative_regulation of ERBB2 67 0.57 44.6 1.48 5.00
101 INT170853 Positive_regulation of Gene_expression of CFD 7 0.23 9.89 1.41 5.00
102 INT173162 Phosphorylation of PPARA 22 0.80 11.09 1.38 5.00
103 INT201463 Negative_regulation of CCNE2 7 0.39 3.31 1.36 5.00
104 INT137382 Negative_regulation of Gene_expression of KRT20 22 0.58 12.29 1.29 5.00
105 INT132577 Binding of RXRB 12 0.30 6.58 1.25 5.00
106 INT114961 Positive_regulation of Gene_expression of NR1H4 6 0.16 3.55 1.23 5.00
107 INT165994 Gene_expression of NANS 12 0.65 3.47 1.22 5.00
108 INT90670 Positive_regulation of KRT1 10 0.44 6.25 1.16 5.00
109 INT127064 Gene_expression of KRT76 7 0.75 1.71 1.1 5.00
110 INT118947 Positive_regulation of FABP4 6 0.67 3.44 1.07 5.00
111 INT148121 Gene_expression of KRT8 35 0.65 29.07 1.05 5.00
112 INT5006 Transcription of KRT20 9 0.46 7.11 1.03 5.00
113 INT83479 Gene_expression of KRT18 30 0.65 27.29 1 5.00
114 INT206467 Gene_expression of IARS 11 0.33 6.65 0.93 5.00
115 INT68186 Gene_expression of GOT2 11 0.65 6.01 0.91 5.00
116 INT125092 Negative_regulation of Binding of ESR1 8 0.42 4.15 0.82 5.00
117 INT102813 Regulation of Gene_expression of TP53 25 0.59 25.95 0.75 5.00
118 INT127633 Localization of KRT18 5 0.52 5.93 0.75 5.00
119 INT160736 Negative_regulation of KRT7 9 0.41 10.08 0.68 5.00
120 INT2395 Binding of MB 18 0.36 7.53 0.68 5.00
121 INT206139 Phosphorylation of KRT20 8 0.48 9.1 0.66 5.00
122 INT220433 Gene_expression of RXRB 3 0.14 1.83 0.63 5.00
123 INT117437 Protein_catabolism of KRT18 3 0.46 4.64 0.61 5.00
124 INT159190 Gene_expression of KRT5 31 0.65 26.67 0.56 5.00
125 INT95692 Negative_regulation of KRT19 4 0.24 4.07 0.51 5.00
126 INT131931 Binding of KRT7 13 0.36 19.24 0.5 5.00
127 INT106381 Negative_regulation of CEACAM7 8 0.38 7.45 0.5 5.00
128 INT70445 Binding of KRT1 10 0.35 5.38 0.47 5.00
129 INT49676 Positive_regulation of TG 10 0.48 9.09 0.44 5.00
130 INT70561 Regulation of ESRRB 4 0.27 1.03 0.42 5.00
131 INT190362 Negative_regulation of Transcription of PPARA 5 0.42 3.19 0.42 5.00
132 INT189228 Positive_regulation of KRT16 5 0.44 1.89 0.41 5.00
133 INT227017 Gene_expression of KRT17 2 0.45 14.84 0.41 5.00
134 INT233007 Negative_regulation of VIM 6 0.41 3.46 0.36 5.00
135 INT226427 Gene_expression of FABP4 9 0.44 4.07 0.34 5.00
136 INT174112 Positive_regulation of Gene_expression of KRT19 4 0.44 4.28 0.31 5.00
137 INT256425 Negative_regulation of Negative_regulation of KRT19 1 0.06 1.59 0.26 5.00
138 INT151793 Gene_expression of KRT3 36 0.75 2.32 0.26 5.00
139 INT113989 Regulation of Gene_expression of CCND1 11 0.44 7.57 0.24 5.00
140 INT162564 Gene_expression of KRT2 5 0.59 1.75 0.24 5.00
141 INT232945 Positive_regulation of Gene_expression of KRT18 2 0.49 3.54 0.23 5.00
142 INT232970 Localization of KRT19 4 0.41 3.41 0.23 5.00
143 INT232982 Localization of KRT8 2 0.44 2.65 0.23 5.00
144 INT232967 Positive_regulation of Gene_expression of KRT8 2 0.29 3.54 0.23 5.00
145 INT232944 Transcription of KRT75 1 0.43 0.59 0.18 5.00
146 INT232962 Binding of KRT18 4 0.26 2.38 0.18 5.00
147 INT242278 Localization of SIVA1 1 0.01 1.07 0.17 5.00
148 INT228267 Positive_regulation of Gene_expression of TG 5 0.50 2.2 0.17 5.00
149 INT232989 Gene_expression of KRT71 1 0.46 0.45 0.17 5.00
150 INT191155 Binding of HDAC4 5 0.08 2.79 0.17 5.00
151 INT242277 Positive_regulation of SIVA1 1 0.01 1.08 0.17 5.00
152 INT146180 Positive_regulation of Gene_expression of KRT6A 2 0.49 1.43 0.16 5.00
153 INT216395 Negative_regulation of Gene_expression of KRT7 4 0.41 3.57 0.16 5.00
154 INT71389 Positive_regulation of KRT19 3 0.38 4.91 0.13 5.00
155 INT232955 Gene_expression of KRT38 1 0.47 0.12 0.13 5.00
156 INT232964 Gene_expression of KRT28 4 0.48 3.88 0.13 5.00
157 INT256427 Negative_regulation of TG 3 0.42 1.84 0.12 5.00
158 INT232987 Gene_expression of KRT85 1 0.10 1.2 0.11 5.00
159 INT233008 Gene_expression of KRT75 1 0.56 1.07 0.11 5.00
160 INT232951 Gene_expression of KRT81 1 0.39 0.31 0.11 5.00
161 INT187628 Gene_expression of KRT14 15 0.75 11.54 0.1 5.00
162 INT233005 Gene_expression of CAPN9 1 0.02 1.76 0.1 5.00
163 INT233003 Negative_regulation of Gene_expression of KRT17 1 0.25 2.13 0.1 5.00
164 INT145490 Binding of KRT76 2 0.36 0.29 0.09 5.00
165 INT70450 Binding of KRT5 6 0.47 5.72 0.08 5.00
166 INT177318 Negative_regulation of Binding of NR1H4 5 0.14 3.39 0.08 5.00
167 INT164348 Positive_regulation of KRT14 5 0.49 2 0.08 5.00
168 INT232996 Gene_expression of KRT27 1 0.44 0 0.07 5.00
169 INT234477 Localization of NR1H4 3 0.24 2.23 0.07 5.00
170 INT232974 Gene_expression of KRT25 1 0.36 0 0.06 5.00
171 INT230117 Binding of KRT8 6 0.31 2.44 0.05 5.00
172 INT256428 Positive_regulation of CFD 4 0.15 3.67 0.05 5.00
173 INT232981 Positive_regulation of Gene_expression of KRT17 1 0.25 1.06 0.05 5.00
174 INT232972 Gene_expression of KRT34 1 0.30 0 0.05 5.00
175 INT232971 Negative_regulation of KRT17 1 0.22 0.45 0.05 5.00
176 INT175895 Negative_regulation of KRT1 5 0.37 3.23 0.05 5.00
177 INT232957 Binding of KRT19 3 0.23 0.97 0.05 5.00
178 INT232984 Gene_expression of KRT36 1 0.14 0 0.05 5.00
179 INT232986 Negative_regulation of KRT81 1 0.18 0 0.04 5.00
180 INT232991 Localization of KRT5 1 0.33 1.36 0.04 5.00
181 INT232952 Gene_expression of KRT40 1 0.27 0 0.04 5.00
182 INT232920 Regulation of Gene_expression of Krt27 1 0.00 0.11 0.04 5.00
183 INT232919 Gene_expression of Krt27 1 0.01 0.11 0.04 5.00
184 INT233000 Negative_regulation of KRT86 1 0.23 0 0.04 5.00
185 INT212930 Localization of ELL 2 0.15 0.87 0.04 5.00
186 INT233006 Binding of KRT17 1 0.28 0.8 0.04 5.00
187 INT232994 Gene_expression of KRT10 6 0.40 8.2 0.03 5.00
188 INT232999 Positive_regulation of Localization of KRT16 1 0.32 0.37 0 5.00
189 INT233002 Binding of KRT2 1 0.29 0 0 5.00
190 INT232953 Binding of RBPJP3 1 0.03 0.26 0 5.00
191 INT233004 Localization of KRT17 1 0.36 0.19 0 5.00
192 INT186706 Positive_regulation of Anxa4 1 0.07 2.24 0 5.00
193 INT232978 Localization of KRT4 1 0.35 0.2 0 5.00
194 INT232948 Positive_regulation of Phosphorylation of KRT20 1 0.41 0.67 0 5.00
195 INT186708 Positive_regulation of Gene_expression of Anxa4 1 0.05 2.16 0 5.00
196 INT232975 Binding of KRT9 2 0.14 0.8 0 5.00
197 INT225958 Gene_expression of KRT12 13 0.68 1.57 0 5.00
198 INT232949 Positive_regulation of KRT10 1 0.25 0.38 0 5.00
199 INT232980 Binding of KRT3 2 0.29 0.43 0 5.00
200 INT232947 Positive_regulation of RBPJP3 1 0.05 0.19 0 5.00
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