D:Osteoarthritis

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Disease Term
Synonyms Arthritides Degenerative, ARTHRITIS DEGENERATIVE, CHONDROMALACIA PATELLA, Currarino Syndrome, DEGENERATIVE ARTHRITIDES, Degenerative Arthritis, Degenerative Joint Disease, DEGENERATIVE JOINTS, DJD, EROSIVE OSTEOARTHRITIS, Hyaline Cartilage
Documents 9014
Hot Single Events 200
Hot Interactions 200

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Osteoarthritis. They are ordered first by their relevance to Osteoarthritis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT203168 PTGER2 Negative_regulation of Gene_expression of ALOX5AP 1 0.03 2.4 1.18 100.00
2 INT209926 IL1B Regulation of PPARA 1 0.21 2.45 1.2 100.00
3 INT209923 IL17A Negative_regulation of PPARA 1 0.14 2.46 0.99 100.00
4 INT247469 RCT Regulation of OAP 1 0.02 1.8 1.19 100.00
5 INT231716 Binding of IL6 and DIP 1 0.24 1.55 0.87 100.00
6 INT174451 Trav6-3 Regulation of Transcription of Cxcr3 1 0.06 1.86 1 100.00
7 INT323774 Binding of Il6 and OPA6 1 0.01 0.85 0.37 100.00
8 INT203166 Negative_regulation of CPOX Positive_regulation of Gene_expression of LTB4R 1 0.00 0.65 0.34 100.00
9 INT311923 OAP Positive_regulation of Gtf3a 1 0.00 0.7 0.19 100.00
10 INT225787 Ppi-rs Positive_regulation of Gene_expression of Ank 1 0.06 1.44 0.19 100.00
11 INT346230 IL1B Positive_regulation of Binding of RUNX2 1 0.17 0.38 0.19 100.00
12 INT161483 Slc7a12 Regulation of Gene_expression of TGFB1 1 0.14 1.21 0.77 100.00
13 INT161481 Slc7a12 Regulation of Gene_expression of Il1b 1 0.14 1.21 0.77 100.00
14 INT220191 Binding of COL2A1 and PTGER2 1 0.22 0.35 0.18 100.00
15 INT275319 Tg(Ngf)47Kma Positive_regulation of Gpr143 1 0.00 0.59 0.17 100.00
16 INT275318 Binding of Gpr143 and Adamts4 1 0.00 0.6 0.17 100.00
17 INT275317 Binding of Gpr143 and Adamts5 1 0.01 0.61 0.17 100.00
18 INT182259 EDN1 Positive_regulation of Gene_expression of TIMP1 1 0.01 0.27 0.05 100.00
19 INT346267 Binding of HGF and IL6 1 0.04 0.96 0.7 100.00
20 INT172149 IL17A Positive_regulation of Gene_expression of IL1B 1 0.01 0.5 0.43 100.00
21 INT172138 IL17A Positive_regulation of Gene_expression of TNF 1 0.07 0.5 0.43 100.00
22 INT307675 Binding of IL1R1 and SNRNP70 1 0.02 1.05 0.45 99.92
23 INT346280 Binding of COL5A2 and PTK2 1 0.01 0.1 0.05 99.92
24 INT312225 Positive_regulation of INPP5K Positive_regulation of CD44 1 0.15 0.1 0 99.92
25 INT346286 ELANE Positive_regulation of MAPK1 1 0.06 0.65 0.32 99.88
26 INT346281 Binding of ELANE and MAPK1 1 0.04 0.65 0.32 99.88
27 INT278948 LEP Positive_regulation of Gene_expression of PTGER2 1 0.09 4.04 2.69 99.84
28 INT236783 IRF6 Negative_regulation of Gene_expression of TLR4 1 0.01 1.17 0.57 99.84
29 INT251015 OLR1 Regulation of Protein_catabolism of MMP3 1 0.03 0.91 0.4 99.84
30 INT224461 F2RL1 Positive_regulation of CALCRL 1 0.00 0.37 0.31 99.84
31 INT203163 LTB4R Regulation of Gene_expression of ALOX5 1 0.00 0.98 0.41 99.80
32 INT161485 Il1b Regulation of Gene_expression of TGFB1 1 0.47 1.21 0.77 99.80
33 INT100274 IL1RN Negative_regulation of IL1B 5 0.53 1.79 1.65 99.74
34 INT207466 LGALS3 Positive_regulation of Gene_expression of ADAMTS5 1 0.15 0.88 0.51 99.72
35 INT182261 EDN1 Regulation of Gene_expression of MMP1 1 0.17 0.7 0.15 99.70
36 INT182264 EDN1 Positive_regulation of Positive_regulation of MAPK14 1 0.26 0.1 0.05 99.70
37 INT131185 PTH Positive_regulation of Gene_expression of IGF1 3 0.44 3.31 1.31 99.68
38 INT97198 MSD Positive_regulation of MSD Negative_regulation of SGCG 1 0.00 0.36 0.32 99.68
39 INT131184 PTGER2 Positive_regulation of Gene_expression of IGF1 1 0.63 2.47 1.29 99.64
40 INT323773 Binding of Il6 and Lep 1 0.29 3.54 0.6 99.64
41 INT207461 LGALS3 Positive_regulation of Gene_expression of MMP3 1 0.18 0.48 0.21 99.62
42 INT278937 LEP Positive_regulation of Gene_expression of IL6 1 0.32 3.42 1.97 99.60
43 INT346234 MAP2K6 Positive_regulation of MAPK14 1 0.44 1.65 0.77 99.60
44 INT278940 LEP Positive_regulation of Gene_expression of IL8 1 0.34 1.68 0.96 99.60
45 INT182266 EDN1 Positive_regulation of Gene_expression of MMP13 1 0.35 2.03 0.63 99.60
46 INT278965 LEP Positive_regulation of Gene_expression of NOS2 2 0.29 2.12 0.66 99.60
47 INT346237 MAP2K6 Positive_regulation of MAP2K3 1 0.49 1 0.44 99.60
48 INT278961 IL6 Regulation of Gene_expression of LEP 1 0.29 0.89 0.3 99.60
49 INT312085 ELANE Regulation of Regulation of ALOX5 1 0.09 0.64 0.32 99.60
50 INT207465 LGALS3 Regulation of MMP3 1 0.16 0.26 0.22 99.60
51 INT220189 Binding of COL2A1 and TIMP1 1 0.04 0.1 0.05 99.60
52 INT264527 IL1B Positive_regulation of Gene_expression of PTGDS 1 0.07 0.75 0.38 99.56
53 INT220213 Mmp13 Regulation of Protein_catabolism of COL2A1 1 0.49 0.29 0.14 99.56
54 INT247281 GLC1N Negative_regulation of HRAS 1 0.02 1.98 1.62 99.52
55 INT250867 Fgf8 Positive_regulation of Protein_catabolism of Ecm1 1 0.06 4.35 2.14 99.48
56 INT250868 Fgf8 Positive_regulation of Gene_expression of Mmp3 1 0.15 1.73 0.93 99.48
57 INT346232 PREP Negative_regulation of Binding of IL1B 1 0.04 0.47 0.23 99.36
58 INT312099 ELANE Positive_regulation of Gene_expression of PTGER2 1 0.02 0.64 0.32 99.32
59 INT220195 PTGER2 Negative_regulation of Localization of COL2A1 1 0.26 0.51 0.09 99.32
60 INT278953 IL6 Regulation of Gene_expression of PTGER2 1 0.04 1.38 0.67 99.30
61 INT311914 Il1 Negative_regulation of Gene_expression of Col2a1 1 0.01 1.94 1.23 99.28
62 INT346229 PREP Positive_regulation of MAPK14 1 0.13 0.63 0.34 99.26
63 INT220196 Binding of PTGER2 and Negative_regulation of Gene_expression of COL2A1 1 0.26 0.77 0.04 99.24
64 INT26310 IL1B Positive_regulation of ACE2 1 0.18 0.46 0.07 99.24
65 INT207464 LGALS3 Regulation of ADAMTS5 1 0.19 0.26 0.21 99.20
66 INT97197 MSD Negative_regulation of SGCG 1 0.02 0.36 0.32 99.20
67 INT278946 IL6 Regulation of Gene_expression of IL8 1 0.20 1.9 1 99.18
68 INT130721 Binding of IL1B and IL1RN 6 0.05 5.29 2.85 99.18
69 INT209928 IL1B Positive_regulation of MAPK14 2 0.15 1.69 0.87 99.12
70 INT346235 IL1B Positive_regulation of Gene_expression of MAPK14 1 0.15 0.64 0.32 99.12
71 INT160399 Tns3 Regulation of Casr 1 0.30 0.1 0.22 99.08
72 INT160402 Tns3 Regulation of Positive_regulation of Casr 1 0.30 0.1 0.22 99.08
73 INT203178 IL18 Positive_regulation of Gene_expression of Lts1 1 0.01 1.98 1.02 99.02
74 INT312105 ELANE Positive_regulation of Localization of PTGER2 4 0.03 1.3 0.64 99.00
75 INT278957 JAK3 Positive_regulation of Gene_expression of IL8 1 0.28 0.67 0.38 99.00
76 INT278955 JAK3 Positive_regulation of Gene_expression of PRKCA 1 0.12 0.65 0.37 99.00
77 INT278949 JAK3 Positive_regulation of Gene_expression of LEP 1 0.42 0.63 0.36 99.00
78 INT312119 ELANE Positive_regulation of Gene_expression of PTGES 1 0.18 0.74 0.33 99.00
79 INT275320 Binding of Adamts5 and Adamts4 1 0.02 0.6 0.17 99.00
80 INT245313 Negative_regulation of Binding of MMP2 and TIMP1 1 0.01 0.45 0.11 98.92
81 INT196523 Binding of MMP2 and TIMP1 3 0.43 1.94 0.85 98.92
82 INT346233 PREP Regulation of IL1B 1 0.05 1.44 0.69 98.88
83 INT323883 BMI1 Regulation of LEP 1 0.02 2.39 0.23 98.88
84 INT203162 PTGER2 Regulation of Gene_expression of ALOX5AP 1 0.04 1.47 0.94 98.80
85 INT312097 ELANE Regulation of ALOX5 1 0.08 1.75 1.05 98.80
86 INT250873 Fgf8 Positive_regulation of GAG 1 0.55 0.48 0.23 98.80
87 INT312106 EGR1 Regulation of Gene_expression of PTGES 1 0.31 1.06 0.64 98.76
88 INT312089 LTB4R Positive_regulation of ALOX5AP 1 0.01 0.32 0.16 98.74
89 INT312095 LTB4R Positive_regulation of ALOX5 1 0.01 0.32 0.16 98.74
90 INT250871 Il1a Positive_regulation of Protein_catabolism of Ecm1 1 0.01 1.44 0.68 98.72
91 INT209922 IL1B Positive_regulation of Gene_expression of NOS1 1 0.06 0.41 0.12 98.72
92 INT278956 LEP Regulation of Gene_expression of IL8 1 0.30 1.11 0.69 98.60
93 INT278968 LEP Regulation of Gene_expression of IL6 1 0.29 1.11 0.69 98.60
94 INT278951 LEP Regulation of Gene_expression of PTGER2 1 0.07 1.11 0.69 98.60
95 INT224422 Regulation of Binding of NFKB2 and TNFSF11 1 0.13 0.69 0.3 98.48
96 INT224418 Binding of NFKB2 and TNFSF11 1 0.11 0.68 0.3 98.48
97 INT182262 EDN1 Positive_regulation of Gene_expression of NOS2 1 0.28 0.79 0.31 98.48
98 INT231713 Binding of SUGT1 and GPR174 1 0.00 0.82 0.47 98.48
99 INT185373 IRF6 Positive_regulation of Gene_expression of TLR2 1 0.08 2.96 1.04 98.40
100 INT312118 ELANE Regulation of PTGES 1 0.22 0.92 0.49 98.40
101 INT203177 Negative_regulation of CPOX Positive_regulation of Gene_expression of Lts1 1 0.00 0.72 0.46 98.32
102 INT278962 LEP Positive_regulation of CPOX 1 0.05 1.33 1 98.28
103 INT224420 Regulation of Binding of NFKB2 and TNFRSF11B 1 0.13 1.39 0.6 98.20
104 INT224419 Binding of NFKB2 and TNFRSF11B 1 0.11 1.37 0.6 98.20
105 INT231715 GAGE2C Regulation of Localization of IL6 1 0.01 0.58 0.33 98.16
106 INT231714 GPR174 Regulation of Localization of IL6 1 0.01 0.58 0.33 98.16
107 INT182265 EDN1 Positive_regulation of NOS2 1 0.24 0.56 0.22 98.16
108 INT182303 Positive_regulation of Prkaca Positive_regulation of EDN1 Positive_regulation of NOS2 1 0.01 0.27 0.15 98.16
109 INT278944 ZEB1 Negative_regulation of IL1B 1 0.00 1.09 0.39 97.96
110 INT278960 ZEB1 Negative_regulation of MMP3 1 0.00 1.05 0.38 97.96
111 INT278943 ZEB1 Negative_regulation of Gene_expression of MMP3 1 0.00 1.05 0.38 97.96
112 INT250878 Il1a Positive_regulation of Fgf8 Positive_regulation of Ecm1 1 0.01 0.85 0.38 97.96
113 INT250870 Fgf8 Positive_regulation of Ecm1 1 0.04 0.79 0.38 97.96
114 INT278970 MAPK14 Positive_regulation of Gene_expression of IL8 1 0.11 0.66 0.37 97.92
115 INT278938 MAPK14 Positive_regulation of Gene_expression of PRKCA 1 0.05 0.65 0.37 97.92
116 INT278966 MAPK14 Positive_regulation of Gene_expression of LEP 1 0.16 0.62 0.36 97.92
117 INT278958 LEP Positive_regulation of IL1B 1 0.33 1.91 0.74 97.88
118 INT182273 EDN1 Regulation of Gene_expression of BAD 1 0.11 0.73 0.12 97.76
119 INT302833 Gene_expression of Mir155 Negative_regulation of Gene_expression of Mmp3 1 0.03 1 0.57 97.76
120 INT203167 Gene_expression of PTGER2 Positive_regulation of Gene_expression of ALOX5AP 1 0.03 0.67 0.38 97.64
121 INT312091 ALOX5AP Regulation of Transcription of ALOX5 1 0.13 0.37 0.18 97.60
122 INT64718 IL1B Positive_regulation of Gene_expression of IL6 15 0.59 9.37 4.48 97.56
123 INT278971 IL1B Positive_regulation of Gene_expression of NOS2 1 0.14 0.79 0.27 97.56
124 INT182244 EDN1 Positive_regulation of EDN1 Positive_regulation of NOS2 1 0.25 0.29 0.07 97.40
125 INT323870 LEP Regulation of Gene_expression of MMP13 1 0.21 1.76 0.33 97.36
126 INT194859 IL1B Positive_regulation of Gene_expression of MMP13 2 0.52 0.86 0.33 97.36
127 INT323886 BMI1 Regulation of Gene_expression of MMP13 1 0.01 1.13 0.12 97.36
128 INT323868 LEP Regulation of Transcription of COL1A2 1 0.10 0.98 0.09 97.36
129 INT134303 Cpox Negative_regulation of PTGS2 1 0.00 0.77 0.34 97.28
130 INT134302 Cpox Negative_regulation of PTGS2 Negative_regulation of Gene_expression of Ptger2 1 0.00 0.78 0.34 97.28
131 INT203165 Binding of IL10 and PTGER2 1 0.01 0.5 0.25 97.20
132 INT333886 Binding of Lep and Positive_regulation of Gene_expression of Nos2 1 0.39 0.73 0.29 97.20
133 INT333887 Binding of Lep and Positive_regulation of Gene_expression of Il1 1 0.17 0.73 0.29 97.20
134 INT316830 TNF Regulation of CCL5 1 0.02 1.02 0.39 97.16
135 INT247285 GLC1N Positive_regulation of Gene_expression of HRAS 1 0.02 1.3 0.61 97.12
136 INT178087 EDN1 Positive_regulation of MMP13 2 0.23 1.58 0.59 97.08
137 INT103548 Binding of TRPV1 and TRPV3 3 0.37 1.82 2.28 97.04
138 INT171990 Binding of DMD and VDR 5 0.05 2.58 0.39 96.88
139 INT164415 Tgfb1 Regulation of Crlf1 1 0.01 0.78 0.45 96.80
140 INT220197 PTGER2 Negative_regulation of TIMP1 1 0.03 0.23 0.12 96.80
141 INT194914 Mtx1 Regulation of Gene_expression of Nfasc 1 0.00 0.71 0.58 96.76
142 INT351311 Has1 Regulation of Gene_expression of MMP3 1 0.11 1.15 0.95 96.68
143 INT346304 Col2a1 Positive_regulation of Localization of PTGER2 1 0.00 0.18 0.09 96.64
144 INT225775 Enpp1 Positive_regulation of Ppi-rs 1 0.06 2.49 0.44 96.60
145 INT225776 Enpp1 Positive_regulation of Positive_regulation of Ppi-rs 1 0.08 1.67 0.28 96.60
146 INT266396 Binding of Ager and S100a4 1 0.01 0.59 0.1 96.60
147 INT161482 Il1b Negative_regulation of TGFB1 1 0.45 1.17 0.76 96.56
148 INT134301 Cpox Negative_regulation of Gene_expression of Ptger2 1 0.00 0.77 0.34 96.56
149 INT312229 INPP5K Positive_regulation of CD44 1 0.15 0.1 0 96.56
150 INT203171 PTGER2 Negative_regulation of ALOX5 1 0.01 0.89 0.77 96.40
151 INT171909 MAPK8 Positive_regulation of Gene_expression of MAPK1 1 0.08 1.55 0.52 96.40
152 INT171906 MAPK1 Positive_regulation of Gene_expression of MAPK14 1 0.08 1.55 0.52 96.40
153 INT171914 MAPK8IP3 Positive_regulation of Gene_expression of MAPK1 1 0.06 1.55 0.52 96.40
154 INT171907 MAPK8 Positive_regulation of Gene_expression of MAPK14 1 0.06 0.77 0.26 96.40
155 INT171911 MAPK8IP3 Positive_regulation of Gene_expression of MAPK14 1 0.05 0.77 0.26 96.40
156 INT227906 IL10 Regulation of Gene_expression of IL1B 1 0.07 0.57 0.38 96.20
157 INT227909 IL10 Regulation of Gene_expression of TNF 1 0.21 0.57 0.38 96.20
158 INT278947 PTGER2 Regulation of Gene_expression of IL8 1 0.04 0.32 0.16 96.16
159 INT182263 EDN1 Positive_regulation of MMP1 1 0.15 0.43 0.21 96.04
160 INT346305 Binding of ELANE and Col2a1 1 0.00 0.98 0.17 95.80
161 INT312096 ELANE Positive_regulation of Transcription of ALOX5 1 0.06 0.27 0.13 95.76
162 INT264868 Binding of COL1A2 and GOPC 1 0.02 0.3 0.15 95.60
163 INT311918 Insrr Negative_regulation of Tgfbr1 1 0.00 0.87 0.26 95.48
164 INT311900 Acvrl1 Negative_regulation of Insrr 1 0.00 0.86 0.25 95.48
165 INT203169 CPOX Regulation of Gene_expression of PTGER2 2 0.00 0.48 0.29 95.40
166 INT194865 Binding of SIGMAR1 and Positive_regulation of IL1B 1 0.01 0.62 0.35 95.40
167 INT194862 SIGMAR1 Positive_regulation of IL1B 1 0.01 0.62 0.35 95.40
168 INT177457 Il1 Positive_regulation of Gene_expression of Il6 3 0.16 4.47 1.35 95.36
169 INT182258 EDN1 Positive_regulation of Positive_regulation of MMP1 1 0.15 0.47 0.19 95.28
170 INT182271 EDN1 Positive_regulation of Localization of MMP13 1 0.27 0.47 0.19 95.28
171 INT346145 Binding of ADM and TPX2 1 0.01 1.05 0.35 95.24
172 INT227907 TNFRSF1B Regulation of TNF 1 0.01 0.41 0.36 95.24
173 INT323877 LEP Positive_regulation of SOAT1 1 0.20 1.26 0.14 95.20
174 INT231712 GAGE2C Regulation of Transcription of IL6 1 0.01 1.01 0.57 95.16
175 INT350169 Binding of DMD and MRI1 1 0.11 3.08 0.54 95.12
176 INT311902 Acvrl1 Negative_regulation of Tgfbr1 1 0.13 0.87 0.26 95.08
177 INT346133 RAMP2 Regulation of ADM 1 0.13 2.06 0.78 95.08
178 INT171913 MAPK8 Positive_regulation of MAPK9 1 0.07 0.78 0.26 94.96
179 INT312123 ELANE Positive_regulation of ALOX5 1 0.09 0.74 0.4 94.92
180 INT333927 GLUL Positive_regulation of HSPA5 1 0.17 0.78 0.24 94.92
181 INT324899 Edn1 Positive_regulation of Positive_regulation of Mmp9 1 0.10 0.66 0.16 94.80
182 INT227904 TNFRSF1A Regulation of TNF 1 0.01 0.41 0.36 94.76
183 INT231711 GPR174 Regulation of Transcription of IL6 1 0.01 0.96 0.54 94.72
184 INT311908 Acvrl1 Positive_regulation of Gene_expression of Mmp13 1 0.10 0.55 0.23 94.72
185 INT311911 Tgfbr1 Positive_regulation of Gene_expression of Mmp13 1 0.10 0.55 0.23 94.72
186 INT171912 MAPK8IP3 Positive_regulation of MAPK9 1 0.06 0.78 0.26 94.56
187 INT323077 CPOX Negative_regulation of Gene_expression of Ptger2 1 0.00 1.57 1.05 94.24
188 INT264524 PTGDS Negative_regulation of Gene_expression of MMP1 1 0.09 0.5 0.22 94.16
189 INT264526 PTGDS Negative_regulation of Gene_expression of MMP13 1 0.12 0.5 0.22 94.16
190 INT264517 PTGDS Positive_regulation of TFDP1 1 0.17 0.5 0.22 94.16
191 INT264516 PTGDS Positive_regulation of TFDP1 Negative_regulation of Gene_expression of MMP1 1 0.02 0.5 0.22 94.16
192 INT264519 PTGDS Negative_regulation of Positive_regulation of TFDP1 1 0.15 0.5 0.22 94.16
193 INT184159 Egr1 Positive_regulation of Ptges2 1 0.07 0.34 0.19 94.00
194 INT184161 Negative_regulation of Egr1 Positive_regulation of Ptges2 1 0.07 0.34 0.19 94.00
195 INT209924 IL1B Negative_regulation of PPARA 1 0.20 4.38 2.17 93.92
196 INT278950 MAPK8 Negative_regulation of Localization of EPHB2 1 0.25 0.47 0.43 93.88
197 INT278964 MAPK14 Negative_regulation of Localization of EPHB2 1 0.15 0.47 0.43 93.88
198 INT278952 MST1 Regulation of Gene_expression of PTGER2 1 0.00 0.41 0.25 93.84
199 INT278954 MST1 Regulation of Gene_expression of NOS2 1 0.01 0.41 0.25 93.84
200 INT278967 MST1 Regulation of Gene_expression of CPOX 1 0.00 0.41 0.25 93.84

Single Events

The table below shows the top 200 pain related interactions that have been reported for Osteoarthritis. They are ordered first by their pain relevance and then by number of times they were reported in Osteoarthritis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT1760 Gene_expression of PTGER2 524 0.57 226.94 96.4 100.00
2 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 100.00
3 INT129956 Gene_expression of MMP13 145 0.72 60.48 26.98 100.00
4 INT17442 Gene_expression of ALOX5 110 0.75 51.55 18.29 100.00
5 INT4809 Gene_expression of PTGDS 103 0.76 52.94 24.01 100.00
6 INT86024 Gene_expression of PPARA 736 0.78 497.93 91.14 100.00
7 INT100733 Positive_regulation of F2RL1 62 0.70 59.14 35.22 100.00
8 INT1764 Negative_regulation of Gene_expression of PTGER2 81 0.34 34.74 19.45 100.00
9 INT79060 Gene_expression of NOS2 116 0.78 69.25 34.84 100.00
10 INT49437 Gene_expression of OAP 25 0.54 20.12 7.34 100.00
11 INT6484 Binding of IL1B 122 0.47 75.84 35.07 100.00
12 INT236824 Negative_regulation of Gene_expression of PTH1R 10 0.58 9.3 3.42 100.00
13 INT195415 Regulation of Gene_expression of ALOX5AP 10 0.45 6.43 3.13 100.00
14 INT44254 Regulation of Gene_expression of ALOX5 12 0.43 7.06 3.65 100.00
15 INT50672 Positive_regulation of CPOX 205 0.44 125.93 60.06 100.00
16 INT3950 Gene_expression of Ptger2 293 0.77 122.28 62.42 100.00
17 INT117924 Gene_expression of MAP2K3 2 0.72 5.82 2.32 100.00
18 INT291336 Gene_expression of MAP2K6 4 0.70 7.8 2.13 100.00
19 INT85015 Gene_expression of ADM 29 0.73 30.75 10.21 100.00
20 INT1763 Regulation of Gene_expression of PTGER2 43 0.36 23.98 10.95 100.00
21 INT82829 Gene_expression of COMP 104 0.78 57 9.81 100.00
22 INT217742 Positive_regulation of Gene_expression of COL2A1 20 0.67 9.76 4.23 100.00
23 INT18639 Positive_regulation of OAP 16 0.69 10.49 4.57 100.00
24 INT91338 Binding of Lep 31 0.48 26.86 5.39 100.00
25 INT17701 Gene_expression of PTHLH 103 0.78 64.23 8.85 100.00
26 INT181596 Binding of IL1R1 9 0.36 7.99 4.32 100.00
27 INT9682 Positive_regulation of IGF1 238 0.70 120.03 26.36 100.00
28 INT10833 Regulation of Gene_expression of IL8 68 0.62 38.74 18.46 100.00
29 INT86437 Binding of IL6 154 0.48 121.22 29.3 100.00
30 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 100.00
31 INT109929 Phosphorylation of MAPK8 102 0.81 39.98 16.54 100.00
32 INT64171 Regulation of CPOX 109 0.36 55.36 32.96 100.00
33 INT71786 Phosphorylation of MAPK1 256 0.82 110.09 46.17 100.00
34 INT171254 Binding of OAP 7 0.39 8.04 3.42 100.00
35 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27 100.00
36 INT79061 Positive_regulation of NOS2 92 0.65 58.89 23.96 100.00
37 INT108306 Positive_regulation of TNFRSF11B 28 0.60 12.74 4.46 100.00
38 INT146594 Negative_regulation of Gene_expression of LEP 25 0.42 18.88 5.71 100.00
39 INT131187 Regulation of Gene_expression of IGF1 18 0.62 11.18 3.05 100.00
40 INT178604 Gene_expression of TPX2 13 0.37 20.29 6.04 100.00
41 INT231737 Localization of OAP 5 0.50 7.4 2.63 100.00
42 INT209893 Positive_regulation of Gene_expression of TNFRSF11B 31 0.68 11.77 4.8 100.00
43 INT10100 Binding of ELANE 22 0.47 15.32 5.19 100.00
44 INT174427 Positive_regulation of Gene_expression of Cxcr3 8 0.66 10.7 4.66 100.00
45 INT50673 Positive_regulation of Gene_expression of CPOX 156 0.54 97.31 37.03 100.00
46 INT181859 Positive_regulation of Gene_expression of HYAL2 1 0.25 4.99 2.45 100.00
47 INT180163 Positive_regulation of Nfasc 49 0.40 31.96 9.41 100.00
48 INT99070 Gene_expression of Mapk14 147 0.78 103.99 79.59 100.00
49 INT324529 Negative_regulation of Binding of PREP 1 0.37 2.48 1.05 100.00
50 INT185502 Binding of PREP 6 0.37 4.04 1.09 100.00
51 INT182295 Regulation of MMP13 6 0.27 3.33 1.77 100.00
52 INT307684 Binding of IL1RL2 1 0.30 2.39 1.01 100.00
53 INT80690 Positive_regulation of MAPK8 223 0.68 125.63 36.75 100.00
54 INT95607 Regulation of MMP1 19 0.60 7.86 6.18 100.00
55 INT192268 Regulation of Gene_expression of Lts1 6 0.06 3.78 1.49 100.00
56 INT118258 Positive_regulation of ENPP1 3 0.62 4.26 1.16 100.00
57 INT346246 Positive_regulation of Gene_expression of MAP2K6 1 0.45 1.74 0.78 100.00
58 INT346248 Positive_regulation of Gene_expression of MAP2K3 1 0.47 1.73 0.78 100.00
59 INT118095 Regulation of COMP 7 0.43 9.69 3.33 100.00
60 INT37296 Binding of Esr1 117 0.43 62.51 27.33 100.00
61 INT178606 Positive_regulation of Gene_expression of TPX2 4 0.08 8.73 2.71 100.00
62 INT1168 Binding of PROC 62 0.38 44.15 9.04 100.00
63 INT87650 Positive_regulation of EPHB2 49 0.67 22.77 8.25 100.00
64 INT250048 Positive_regulation of Gpr143 12 0.43 5.85 6.1 100.00
65 INT5333 Gene_expression of NPEPPS 45 0.65 26.34 15.25 100.00
66 INT202050 Gene_expression of URB1 1 0.07 5.64 3.81 100.00
67 INT162258 Negative_regulation of Gene_expression of COMP 35 0.58 19.14 3.55 100.00
68 INT145235 Protein_catabolism of Mmp13 3 0.89 2.46 2.03 100.00
69 INT352919 Positive_regulation of Gene_expression of RHOB 1 0.35 2.21 0.96 100.00
70 INT324530 Positive_regulation of Gene_expression of PREP 2 0.44 1.45 0.58 100.00
71 INT62071 Positive_regulation of Gene_expression of PTHLH 13 0.70 19.32 1.73 100.00
72 INT32760 Regulation of Gene_expression of PTHLH 4 0.51 6.32 1 100.00
73 INT62072 Negative_regulation of Gene_expression of PTHLH 3 0.43 4.45 0.85 100.00
74 INT279122 Regulation of Gene_expression of COMP 3 0.39 8.82 3.19 100.00
75 INT18636 Negative_regulation of OAP 9 0.37 5.05 2.13 100.00
76 INT9239 Regulation of Gene_expression of IL6 106 0.61 75.24 36.53 100.00
77 INT134651 Binding of TLR4 89 0.48 66.96 23.19 100.00
78 INT346258 Negative_regulation of Gene_expression of MAP2K6 1 0.38 1.08 0.45 100.00
79 INT346251 Negative_regulation of Gene_expression of MAP2K3 1 0.40 1.08 0.45 100.00
80 INT79063 Regulation of Gene_expression of NOS2 6 0.43 3.68 1.7 100.00
81 INT250880 Gene_expression of st 1 0.01 3.25 1.63 100.00
82 INT311921 Negative_regulation of Gene_expression of OAP 1 0.02 0.94 0.69 100.00
83 INT328235 Positive_regulation of PRCD 1 0.28 1.61 0.68 100.00
84 INT118516 Positive_regulation of Positive_regulation of F2RL1 7 0.49 4.63 6.33 100.00
85 INT224483 Regulation of Regulation of MMP13 2 0.15 1.16 0.86 100.00
86 INT311920 Regulation of Gene_expression of OAP 1 0.02 0.92 0.67 100.00
87 INT328238 Regulation of PRCD 1 0.17 1.37 0.27 100.00
88 INT311922 Protein_catabolism of OAP 1 0.03 1.06 0.55 100.00
89 INT17938 Binding of Cpe 28 0.48 11.17 13.62 100.00
90 INT75523 Regulation of MAPK8 21 0.33 11.18 4.28 100.00
91 INT70265 Regulation of MRI1 42 0.39 30.95 14.18 100.00
92 INT134145 Negative_regulation of Gene_expression of PTGES 11 0.51 5.32 2.73 100.00
93 INT224492 Regulation of Regulation of MMP1 1 0.09 0.77 0.66 100.00
94 INT75531 Regulation of MAPK1 70 0.61 34.39 15.42 100.00
95 INT202008 Binding of OPA6 2 0.35 1.98 1.11 100.00
96 INT141969 Positive_regulation of Gene_expression of ADM 4 0.57 4.07 1.2 100.00
97 INT46849 Regulation of TPX2 5 0.24 6.27 2.1 100.00
98 INT155928 Positive_regulation of Gene_expression of PARP1 13 0.68 6.54 2.1 100.00
99 INT312240 Negative_regulation of Gene_expression of RUNX2 2 0.39 0.74 0.3 100.00
100 INT177459 Negative_regulation of RCT 13 0.25 7.9 2.7 100.00
101 INT57504 Positive_regulation of Positive_regulation of GUSB 2 0.33 1.25 1.16 100.00
102 INT3164 Positive_regulation of GUSB 4 0.49 2.67 1.47 100.00
103 INT97152 Protein_catabolism of COL1A1 11 0.74 8.03 2.3 100.00
104 INT57503 Positive_regulation of Positive_regulation of HEXDC 1 0.50 1 0.96 100.00
105 INT352915 Negative_regulation of Gene_expression of GPX3 1 0.03 0.81 0.33 100.00
106 INT192269 Regulation of Lts1 5 0.08 3.53 0.75 100.00
107 INT76573 Negative_regulation of Vcam1 26 0.58 24.36 9.84 100.00
108 INT36173 Positive_regulation of Gs 17 0.43 7.48 8.19 100.00
109 INT39282 Negative_regulation of SOD2 27 0.59 16.89 7.03 100.00
110 INT52531 Gene_expression of Nfkb1 153 0.75 82.84 42.9 100.00
111 INT11362 Regulation of Localization of SERPINE1 3 0.39 1.55 0.69 100.00
112 INT149106 Binding of SOD3 1 0.42 0.53 0.19 100.00
113 INT323765 Negative_regulation of Binding of Lep 1 0.37 0.91 0.42 100.00
114 INT328237 Protein_catabolism of PRCD 1 0.61 0.82 0.06 100.00
115 INT224486 Regulation of Phosphorylation of MAPK8 2 0.33 0.52 0.52 100.00
116 INT224498 Regulation of Positive_regulation of EPHB2 1 0.26 0.46 0.52 100.00
117 INT29389 Positive_regulation of OA1 1 0.02 0.85 0.42 100.00
118 INT29390 Binding of OA1 1 0.01 0.84 0.42 100.00
119 INT69321 Regulation of Gene_expression of PTGS2 27 0.61 13.27 9.53 100.00
120 INT39867 Binding of Col2a1 9 0.35 7.65 3.18 100.00
121 INT176461 Protein_catabolism of Esr1 1 0.12 0.37 0.16 100.00
122 INT292223 Positive_regulation of Gene_expression of NFAT5 2 0.50 1.11 0.16 100.00
123 INT328236 Positive_regulation of Protein_catabolism of PRCD 1 0.28 0.37 0.06 100.00
124 INT148384 Positive_regulation of HEY1 19 0.43 29.76 5.89 100.00
125 INT9197 Binding of PTGS1 44 0.48 18.48 16.26 100.00
126 INT12893 Regulation of MPPE1 1 0.03 0.45 0.22 100.00
127 INT81194 Binding of CPOX 40 0.29 23.7 18.95 100.00
128 INT323817 Positive_regulation of Gene_expression of SLC6A12 1 0.48 0.26 0.13 100.00
129 INT106320 Positive_regulation of Gene_expression of S100A4 2 0.48 0.84 0.65 100.00
130 INT212163 Gene_expression of DEGS1 1 0.09 0.37 0.17 100.00
131 INT126751 Regulation of Gene_expression of IL10 16 0.44 10.84 5.22 100.00
132 INT124050 Binding of Sema5a 1 0.03 2.46 2.3 100.00
133 INT68115 Binding of LPCAT3 1 0.27 1.28 0.8 100.00
134 INT207472 Negative_regulation of Gene_expression of LGALS3 1 0.41 0.58 0.22 100.00
135 INT174054 Positive_regulation of Gene_expression of Lep 25 0.69 21.3 3.72 99.98
136 INT9237 Regulation of Gene_expression of IL1B 49 0.62 30.69 20.34 99.98
137 INT247294 Regulation of Gene_expression of HRAS 1 0.04 1.8 1.02 99.98
138 INT73234 Positive_regulation of Lbp 13 0.69 12.55 8.57 99.98
139 INT133889 Gene_expression of Adamts1 78 0.76 48.05 6.58 99.96
140 INT231721 Binding of DIP 1 0.16 5.53 3.24 99.96
141 INT20981 Binding of HRAS 42 0.48 24.49 4.23 99.96
142 INT2250 Binding of REG3A 3 0.47 3.58 1.33 99.96
143 INT231725 Positive_regulation of DIP 1 0.20 0.84 0.36 99.96
144 INT2867 Gene_expression of CALCA 247 0.78 78.78 138.47 99.96
145 INT247301 Binding of HAS1 1 0.32 1.02 0.84 99.96
146 INT21869 Negative_regulation of Otc 16 0.58 8.43 3.67 99.96
147 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 99.92
148 INT165054 Gene_expression of MIR146A 45 0.58 82.87 28.82 99.92
149 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 99.92
150 INT29496 Gene_expression of MMP3 136 0.75 49.49 41.78 99.92
151 INT316778 Positive_regulation of Gene_expression of ENPP1 1 0.62 7.2 1.97 99.92
152 INT316776 Positive_regulation of Gene_expression of ANKH 1 0.31 5.29 1.49 99.92
153 INT48235 Negative_regulation of NPEPPS 72 0.46 44.54 25.03 99.92
154 INT75907 Binding of LEP 53 0.46 46.65 8.44 99.92
155 INT269144 Gene_expression of Mia1 8 0.59 11.84 6.16 99.92
156 INT66709 Transcription of IGF1 13 0.71 5.65 1.64 99.92
157 INT180497 Binding of MRI1 45 0.42 28.35 14.77 99.92
158 INT69878 Positive_regulation of Gene_expression of Gtf3a 48 0.29 36.78 13.57 99.92
159 INT43727 Negative_regulation of Gene_expression of MMP3 16 0.40 4.81 7.18 99.92
160 INT72166 Positive_regulation of Gene_expression of RETNLB 14 0.24 10.23 7.27 99.92
161 INT91430 Positive_regulation of CD44 25 0.69 15.43 1.76 99.92
162 INT133317 Positive_regulation of Binding of CD44 6 0.55 6.28 0 99.92
163 INT122584 Negative_regulation of Gene_expression of PPARA 56 0.58 37.61 9.76 99.90
164 INT250829 Positive_regulation of Gene_expression of Mia 2 0.18 1.67 0.92 99.90
165 INT212162 Positive_regulation of DEGS1 1 0.07 0.57 0.46 99.90
166 INT168410 Gene_expression of Cxcr3 81 0.75 84.03 37.01 99.88
167 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 99.88
168 INT83950 Gene_expression of Cxcr1 31 0.59 27.76 13.91 99.88
169 INT182223 Gene_expression of CXCR5 57 0.76 51.49 28.4 99.88
170 INT83951 Gene_expression of Cxcr2 31 0.71 19.36 7.24 99.88
171 INT162614 Positive_regulation of Mia 1 0.44 1.82 2.25 99.88
172 INT174443 Negative_regulation of Gene_expression of Cxcr3 4 0.41 4.83 1.62 99.88
173 INT174416 Negative_regulation of Gene_expression of Cxcr2 2 0.33 2.06 0.82 99.88
174 INT117143 Negative_regulation of Gene_expression of Cxcr1 4 0.33 5.35 2.78 99.88
175 INT17596 Gene_expression of CFHR1 24 0.67 3.07 1.61 99.88
176 INT101517 Negative_regulation of PPARA 168 0.57 112.24 21.41 99.86
177 INT195414 Gene_expression of ALOX5AP 65 0.72 31.22 15.25 99.84
178 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 99.84
179 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 99.84
180 INT51685 Gene_expression of LTB4R 87 0.58 68.69 31.72 99.84
181 INT1765 Positive_regulation of Gene_expression of PTGER2 140 0.51 68.68 27 99.84
182 INT17881 Gene_expression of LEP 278 0.78 221.61 48.31 99.84
183 INT50670 Gene_expression of CPOX 763 0.76 442.13 195.02 99.84
184 INT49750 Negative_regulation of CPOX 735 0.58 360.06 274.19 99.84
185 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 99.84
186 INT233812 Gene_expression of PTH1R 32 0.77 18.15 6.15 99.84
187 INT100732 Gene_expression of F2RL1 55 0.78 38.89 19.45 99.84
188 INT127022 Gene_expression of Lts1 43 0.23 28.29 12.64 99.84
189 INT1761 Positive_regulation of PTGER2 135 0.49 90.17 26.26 99.84
190 INT130731 Protein_catabolism of COL2A1 47 0.96 21.86 9.28 99.84
191 INT4804 Positive_regulation of Gene_expression of PTGDS 10 0.68 21.43 11.14 99.84
192 INT20552 Negative_regulation of Gene_expression of COL2A1 29 0.56 11.92 4.81 99.84
193 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86 99.84
194 INT172001 Gene_expression of ANKH 2 0.38 11.92 3.12 99.84
195 INT111156 Negative_regulation of Dkk1 21 0.58 20.08 4.27 99.84
196 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 99.84
197 INT129962 Positive_regulation of Gene_expression of MMP13 41 0.65 20.74 8.54 99.84
198 INT117223 Gene_expression of TLR4 348 0.78 206.18 54.42 99.84
199 INT12720 Positive_regulation of Il1 246 0.70 195.97 72.05 99.84
200 INT140191 Positive_regulation of Gene_expression of Mmp13 25 0.67 13.47 9.71 99.84
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