D:Osteochondrodysplasias

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Disease Term
Synonyms DYSCHONDROPLASIA, DYSCHONDROPLASIAS, Dysplasia Multiple Epiphyseal, Dysplasia Spondyloepiphyseal, Dysplasias Multiple Epiphyseal, DYSPLASIAS SPONDYLOEPIPHYSEAL, Epiphyseal Dysplasia Multiple, EPIPHYSEAL DYSPLASIAS MULTIPLE, Hyperostosis Corticalis Generalisata, Melnick Needles Syndrome, MULTIPLE EPIPHYSEAL DYSPLASIA
Documents 82
Hot Single Events 54
Hot Interactions 12

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Osteochondrodysplasias. They are ordered first by their relevance to Osteochondrodysplasias and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT279107 Binding of COMP and MATN3 1 0.41 1.43 0.2 100.00
2 INT279106 MATN3 Regulation of COMP 1 0.44 0.67 0 100.00
3 INT279108 MATN3 Regulation of Localization of COMP 1 0.44 0.67 0 100.00
4 INT289788 Binding of Comp and Scn8a 1 0.16 1.37 0 100.00
5 INT289794 Binding of Comp and Fn1 1 0.07 2.59 0.12 94.64
6 INT312289 Binding of Col9a1 and Comp 1 0.09 1.38 0 92.80
7 INT312291 Binding of Comp and Matn3 1 0.06 1.37 0 91.36
8 INT289789 Comp Positive_regulation of Gene_expression of Rer1 1 0.55 0.8 0.03 90.16
9 INT289793 Binding of Comp and Ecm1 1 0.05 2.5 0.12 89.04
10 INT289790 Binding of Col7a1 and Comp 1 0.14 1.2 0.12 86.72
11 INT289795 Binding of COMP and Comp 1 0.02 0.99 0 83.08
12 INT279109 Binding of COL9A2 and MATN3 1 0.48 0.64 0.1 81.84
13 INT279110 COMP Regulation of Localization of MATN3 1 0.59 0.45 0 75.32
14 INT312290 Binding of Col9a1 and Matn3 1 0.02 0.65 0 73.48
15 INT197794 Negative_regulation of Pthlh Regulation of Ihh 1 0.36 1.33 0 5.00
16 INT307306 Gene_expression of COMP Positive_regulation of CALR 1 0.27 0.99 0 5.00
17 INT307305 Gene_expression of COMP Positive_regulation of Positive_regulation of CALR 1 0.27 0.41 0 5.00
18 INT307307 COMP Positive_regulation of EREG 1 0.01 0.46 0 5.00
19 INT289791 Comp Regulation of Gene_expression of Col7a1 1 0.20 0.21 0 5.00
20 INT307309 Binding of CALR and EREG 1 0.00 0.83 0 5.00
21 INT307310 Binding of CALR and COMP 1 0.28 0.82 0 5.00
22 INT307308 Binding of COMP and EREG 1 0.01 0.41 0 5.00
23 INT197793 Pthlh Regulation of Ihh 1 0.22 1.32 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Osteochondrodysplasias. They are ordered first by their pain relevance and then by number of times they were reported in Osteochondrodysplasias. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT82828 Positive_regulation of COMP 45 0.61 35.12 6.2 100.00
2 INT82829 Gene_expression of COMP 104 0.78 57 9.81 100.00
3 INT118097 Localization of COMP 18 0.70 9.99 1.42 100.00
4 INT59899 Regulation of MATN3 4 0.45 7.61 1.6 100.00
5 INT45510 Binding of Scn8a 4 0.31 3.89 0.25 100.00
6 INT248308 Regulation of Localization of MATN3 2 0.27 2.48 0.71 100.00
7 INT162258 Negative_regulation of Gene_expression of COMP 35 0.58 19.14 3.55 100.00
8 INT47992 Gene_expression of Scn8a 14 0.78 4.15 3.83 100.00
9 INT279130 Negative_regulation of Localization of COMP 5 0.51 3.75 0.69 100.00
10 INT279119 Regulation of Gene_expression of MATN3 1 0.45 0.83 0 100.00
11 INT279122 Regulation of Gene_expression of COMP 3 0.39 8.82 3.19 100.00
12 INT118095 Regulation of COMP 7 0.43 9.69 3.33 100.00
13 INT131844 Gene_expression of MATN3 12 0.78 9.65 0.92 99.98
14 INT279127 Negative_regulation of Gene_expression of MATN3 1 0.43 0.73 0 99.98
15 INT70916 Binding of Thim 13 0.02 8.35 1.72 99.98
16 INT97909 Binding of COMP 13 0.37 5.98 1.22 99.90
17 INT97908 Binding of Col9a2 3 0.18 2.51 0.29 99.90
18 INT135879 Localization of MATN3 12 0.80 10.31 1.44 99.84
19 INT320806 Binding of SLC26A2 1 0.32 1.06 0.19 99.74
20 INT312287 Gene_expression of Col9a1 1 0.21 2.94 0 99.70
21 INT312282 Gene_expression of Col9a3 1 0.52 1.16 0 99.70
22 INT60710 Gene_expression of Col7a1 217 0.78 113.2 35.2 99.54
23 INT312284 Binding of Comp 1 0.30 3.08 0 98.68
24 INT312286 Binding of Col9a1 1 0.10 1.37 0 98.68
25 INT312283 Binding of Matn3 1 0.06 1.31 0 98.68
26 INT3364 Binding of SGCG 87 0.47 31.93 17.24 98.12
27 INT60713 Binding of Col7a1 47 0.43 22.52 6.29 97.62
28 INT142340 Positive_regulation of Chkb 3 0.47 6.44 0.38 97.22
29 INT312285 Positive_regulation of Positive_regulation of Chkb 1 0.24 1.02 0 97.22
30 INT197143 Positive_regulation of Renbp 15 0.33 9.41 1.31 97.08
31 INT184305 Gene_expression of Comp 53 0.77 31.66 2.2 96.76
32 INT443 Localization of POMC 1020 0.81 284.52 443.17 96.76
33 INT134966 Localization of Col7a1 23 0.42 16.4 5.24 96.00
34 INT187090 Positive_regulation of Localization of Col7a1 4 0.07 3.16 0.51 96.00
35 INT279128 Negative_regulation of Localization of MATN3 2 0.43 0.92 0 95.68
36 INT65260 Positive_regulation of Col7a1 95 0.69 61.73 18.42 95.24
37 INT53704 Negative_regulation of Col7a1 42 0.35 22.4 6.88 93.24
38 INT97906 Binding of Col9a3 1 0.07 0.89 0.09 92.52
39 INT97907 Binding of Col9a1 1 0.10 0.89 0.09 92.52
40 INT255397 Binding of SCAP 3 0.27 1.04 0.24 91.44
41 INT65261 Regulation of Col7a1 18 0.55 8.7 1.33 91.36
42 INT8052 Negative_regulation of COMP 46 0.58 13.73 2.22 91.00
43 INT131456 Negative_regulation of MMRN1 14 0.19 9.49 2.29 91.00
44 INT307330 Negative_regulation of MATN3 1 0.29 0.57 0.04 91.00
45 INT279124 Binding of SFI1 1 0.36 0.73 0.03 90.84
46 INT279123 Binding of PDIA4 1 0.28 1.15 0.1 90.40
47 INT59900 Binding of MATN3 13 0.42 17.19 3.59 90.24
48 INT183125 Negative_regulation of SULF1 2 0.42 2.26 0.13 85.60
49 INT289778 Gene_expression of Rer1 1 0.65 0.67 0.03 84.96
50 INT120649 Localization of UPF1 3 0.03 0.93 0.22 82.96
51 INT279126 Localization of COL9A2 2 0.64 0.77 0 82.64
52 INT91432 Binding of MMRN1 23 0.36 9.79 2.95 82.36
53 INT279125 Binding of COL9A2 2 0.32 2.59 0.36 82.36
54 INT289776 Localization of Dnajc1 1 0.11 1.86 0.08 80.16
55 INT205401 Gene_expression of Chkb 32 0.51 13.99 0.77 79.40
56 INT279121 Positive_regulation of Localization of MCC 1 0.01 0.38 0 77.08
57 INT279129 Localization of MCC 1 0.02 0.37 0 77.08
58 INT126904 Negative_regulation of Smarcal1 1 0.49 1.22 0.6 75.96
59 INT73223 Gene_expression of UPF1 78 0.41 31.44 9.94 74.76
60 INT279120 Localization of COL6A2 1 0.24 0.26 0 70.68
61 INT35584 Binding of ACLY 22 0.35 31.78 7.17 66.24
62 INT155565 Gene_expression of Efemp2 22 0.67 7.24 0.13 61.60
63 INT184306 Localization of Comp 2 0.69 5.1 0.12 60.52
64 INT289780 Positive_regulation of Localization of Dnajc1 1 0.08 0.84 0 59.88
65 INT251821 Negative_regulation of COL11A1 3 0.42 3.45 0.16 59.52
66 INT261721 Negative_regulation of Stl2 1 0.07 1.38 0.16 57.12
67 INT134968 Localization of Ecm1 20 0.32 27.27 4.31 56.40
68 INT245751 Gene_expression of COL9A2 4 0.65 1.83 0.04 56.16
69 INT307323 Negative_regulation of Gene_expression of COL9A2 1 0.06 0.74 0.04 56.16
70 INT22781 Binding of COL7A1 76 0.48 41.59 6.66 54.28
71 INT105021 Binding of GOPC 187 0.40 60.39 20.38 50.00
72 INT15744 Localization of GYPA 12 0.64 7.19 2.61 50.00
73 INT320805 Gene_expression of SLC26A2 1 0.57 1.1 0.19 50.00
74 INT320807 Positive_regulation of SLC26A2 1 0.59 0.46 0.07 50.00
75 INT134967 Gene_expression of Ecm1 66 0.29 38.4 7.16 45.60
76 INT119540 Binding of Nfe2l2 29 0.48 6.34 1.74 44.04
77 INT185240 Binding of Fgf2 14 0.37 7.39 0.59 44.04
78 INT205617 Negative_regulation of Positive_regulation of Renbp 1 0.16 1.04 0.21 37.68
79 INT14281 Gene_expression of Hspa5 44 0.63 34.19 3.31 37.36
80 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38 36.72
81 INT289779 Regulation of Localization of Comp 1 0.39 1.29 0 36.24
82 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 27.72
83 INT200470 Positive_regulation of Gene_expression of COMP 13 0.69 13.73 2.93 10.72
84 INT289786 Gene_expression of Dnajc1 1 0.10 0.43 0 6.12
85 INT184307 Positive_regulation of Gene_expression of Comp 6 0.50 2.48 0.59 5.28
86 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
87 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
88 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 5.00
89 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 5.00
90 INT173693 Localization of Gopc 249 0.65 70.49 38.81 5.00
91 INT326 Gene_expression of Gnrhr 105 0.76 35.87 34.93 5.00
92 INT15610 Localization of GOPC 223 0.65 68.26 28.7 5.00
93 INT127435 Gene_expression of Per1 89 0.77 13.94 22.31 5.00
94 INT170444 Binding of Gopc 172 0.39 45.05 20.71 5.00
95 INT88544 Gene_expression of MMRN1 102 0.75 68.8 14.55 5.00
96 INT80222 Negative_regulation of Bcl2 82 0.58 69.16 13.18 5.00
97 INT37618 Gene_expression of Col2a1 50 0.70 33.88 11.58 5.00
98 INT110178 Phosphorylation of MAPK14 40 0.68 19.38 10.37 5.00
99 INT80220 Positive_regulation of Bcl2 71 0.58 57.73 7.86 5.00
100 INT84572 Gene_expression of Zmat3 67 0.07 37.61 5.86 5.00
101 INT128324 Regulation of Gene_expression of Per1 11 0.61 1.95 5.22 5.00
102 INT88545 Localization of MMRN1 21 0.78 16.67 4.01 5.00
103 INT185246 Gene_expression of Psmd1 26 0.50 8.89 3.73 5.00
104 INT173878 Gene_expression of ACAN 32 0.75 9.35 3.55 5.00
105 INT171233 Binding of Ecm1 25 0.07 12.41 3.36 5.00
106 INT22502 Gene_expression of Hal 21 0.53 9.8 3.32 5.00
107 INT114295 Gene_expression of Gli2 10 0.54 7.58 2.95 5.00
108 INT169987 Transcription of GOPC 45 0.60 21.88 2.61 5.00
109 INT54555 Negative_regulation of CALR 10 0.41 4.41 2.4 5.00
110 INT134964 Regulation of Ecm1 13 0.10 7.45 2.37 5.00
111 INT289775 Negative_regulation of Comp 4 0.41 5.69 2.2 5.00
112 INT126513 Gene_expression of Col1a1 23 0.75 10.92 2.18 5.00
113 INT160622 Gene_expression of Pth1r 7 0.77 6.37 2 5.00
114 INT197791 Regulation of Pth1r 2 0.27 1.31 1.99 5.00
115 INT164407 Negative_regulation of Gene_expression of Col2a1 6 0.39 4 1.78 5.00
116 INT164410 Negative_regulation of Col2a1 4 0.39 3.75 1.53 5.00
117 INT182297 Positive_regulation of Phosphorylation of MAPK14 7 0.42 3.36 1.53 5.00
118 INT72138 Gene_expression of Pthlh 18 0.75 17.68 1.49 5.00
119 INT118559 Positive_regulation of Hspa5 20 0.61 15.66 1.45 5.00
120 INT197789 Regulation of Gene_expression of Pth1r 2 0.23 1.68 1.38 5.00
121 INT167056 Gene_expression of CALR 29 0.75 20.05 1.25 5.00
122 INT81768 Negative_regulation of Chrna4 5 0.42 1.97 1.2 5.00
123 INT205618 Gene_expression of Renbp 15 0.26 9.26 1.04 5.00
124 INT21940 Positive_regulation of CALR 15 0.40 17.42 0.95 5.00
125 INT118098 Protein_catabolism of COMP 5 0.66 2.76 0.9 5.00
126 INT116314 Gene_expression of Myod1 38 0.70 16.6 0.89 5.00
127 INT289785 Negative_regulation of Gene_expression of Comp 4 0.37 3.14 0.88 5.00
128 INT192156 Negative_regulation of Col1a1 6 0.39 3.92 0.8 5.00
129 INT89340 Positive_regulation of EREG 5 0.69 4.98 0.77 5.00
130 INT177347 Positive_regulation of Gene_expression of Gli2 3 0.25 2.61 0.69 5.00
131 INT153257 Regulation of Ptch1 6 0.36 5.92 0.67 5.00
132 INT162801 Localization of CALR 7 0.73 8.69 0.6 5.00
133 INT174106 Binding of Renbp 18 0.24 15.82 0.58 5.00
134 INT140984 Regulation of Ihh 5 0.54 2.81 0.56 5.00
135 INT205619 Regulation of Renbp 6 0.17 1.91 0.55 5.00
136 INT229465 Localization of Vim 6 0.47 1.23 0.47 5.00
137 INT184310 Regulation of Comp 2 0.49 1.81 0.41 5.00
138 INT89341 Gene_expression of EREG 3 0.78 2.38 0.38 5.00
139 INT181034 Localization of Zmat3 3 0.06 1.51 0.28 5.00
140 INT195871 Positive_regulation of Gene_expression of CALR 9 0.29 3 0.27 5.00
141 INT126512 Negative_regulation of Gene_expression of Col1a1 3 0.39 2.2 0.27 5.00
142 INT212536 Negative_regulation of COL3A1 2 0.57 3.53 0.21 5.00
143 INT272484 Negative_regulation of Myod1 8 0.39 6.77 0.2 5.00
144 INT197792 Regulation of Pthlh 3 0.24 2.47 0.18 5.00
145 INT317881 Transcription of Eef1a1 2 0.03 1.38 0.18 5.00
146 INT221002 Transcription of COMP 2 0.60 1.79 0.16 5.00
147 INT200984 Positive_regulation of FIBP 2 0.12 1.12 0.14 5.00
148 INT259244 Negative_regulation of TNXB 1 0.42 2.15 0.13 5.00
149 INT252117 Gene_expression of Spata20 3 0.04 1.42 0.1 5.00
150 INT141785 Negative_regulation of GALNS 3 0.59 1.92 0.09 5.00
151 INT329075 Transcription of MYT1 1 0.27 0.37 0.08 5.00
152 INT329073 Regulation of Myt1 1 0.42 0.34 0.08 5.00
153 INT329074 Transcription of Pcmtd2 1 0.66 0.37 0.08 5.00
154 INT272469 Negative_regulation of Gene_expression of Myod1 5 0.39 2.82 0.07 5.00
155 INT307328 Negative_regulation of Positive_regulation of FIBP 1 0.01 0.95 0.06 5.00
156 INT329071 Negative_regulation of Arfgap1 1 0.41 1.14 0.03 5.00
157 INT307325 Negative_regulation of Gene_expression of EREG 1 0.01 0.31 0.03 5.00
158 INT329072 Negative_regulation of Kcnq2 1 0.42 1.14 0.03 5.00
159 INT307327 Negative_regulation of Localization of COL9A2 1 0.06 0.35 0 5.00
160 INT289783 Negative_regulation of Hspa5 2 0.22 0.7 0 5.00
161 INT307333 Protein_catabolism of ZNF70 1 0.01 0.68 0 5.00
162 INT197790 Gene_expression of Tmem150c 1 0.01 1.06 0 5.00
163 INT307324 Positive_regulation of Positive_regulation of CALR 1 0.25 0.36 0 5.00
164 INT289784 Positive_regulation of Binding of Ecm1 1 0.06 0.49 0 5.00
165 INT307322 Negative_regulation of Localization of MMRN1 1 0.04 0.18 0 5.00
166 INT272950 Regulation of Gene_expression of Myod1 1 0.41 0.7 0 5.00
167 INT289781 Regulation of Gene_expression of Comp 1 0.39 0.39 0 5.00
168 INT307329 Negative_regulation of Positive_regulation of COMP 1 0.38 0.12 0 5.00
169 INT289777 Transcription of Comp 1 0.53 0 0 5.00
170 INT307331 Negative_regulation of Positive_regulation of CALR 1 0.29 0.36 0 5.00
171 INT307326 Negative_regulation of Gene_expression of CALR 3 0.25 1.78 0 5.00
172 INT289782 Regulation of Negative_regulation of Col7a1 1 0.20 0.25 0 5.00
173 INT307332 Negative_regulation of Localization of CALR 1 0.29 0.72 0 5.00
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