D:Osteochondroma

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pChart

Disease Term
Synonyms Cartilaginous Exostoses, Cartilaginous Exostosis, Chondrosteoma, Chondrosteomas, Exostoses Cartilaginous, Exostoses Osteocartilaginous, Exostosis Cartilaginous, Exostosis Osteocartilaginous, Osteocartilaginous Exostoses, Osteocartilaginous Exostosis, Osteochondromas
Documents 237
Hot Single Events 40
Hot Interactions 3

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Osteochondroma. They are ordered first by their relevance to Osteochondroma and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT150351 Binding of EXT1 and MMP12 1 0.04 3.68 0.29 91.68
2 INT301364 Stat1 Positive_regulation of Cdkn1a 1 0.03 0.39 0 82.88
3 INT301365 Stat1 Positive_regulation of Cdkn1a 1 0.03 0.38 0 82.48
4 INT301366 Fgf18 Positive_regulation of Fgfr3 1 0.04 0.34 0 73.84
5 INT203638 Binding of MR1 and GOPC 1 0.04 1.43 0.05 54.80
6 INT197794 Negative_regulation of Pthlh Regulation of Ihh 1 0.36 1.33 0 5.00
7 INT208152 Binding of CDK4 and MDM2 1 0.01 1.11 0 5.00
8 INT197793 Pthlh Regulation of Ihh 1 0.22 1.32 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Osteochondroma. They are ordered first by their pain relevance and then by number of times they were reported in Osteochondroma. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT228618 Gene_expression of EXT1 4 0.77 3.7 0 99.80
2 INT228613 Negative_regulation of Gene_expression of EXT1 1 0.42 1.08 0 99.80
3 INT301358 Negative_regulation of Ext1 2 0.42 1.09 0 99.58
4 INT235835 Negative_regulation of Gene_expression of Hspg2 3 0.15 1.26 0.52 99.56
5 INT112883 Gene_expression of Hspg2 22 0.65 6.54 4.95 99.56
6 INT228615 Gene_expression of EXT2 1 0.66 1.55 0 99.28
7 INT228616 Negative_regulation of Gene_expression of EXT2 1 0.49 0.78 0 99.28
8 INT168369 Binding of NPHS2 1 0.32 0.58 0.24 99.12
9 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38 98.92
10 INT72138 Gene_expression of Pthlh 18 0.75 17.68 1.49 98.92
11 INT124850 Gene_expression of Tpt1 42 0.77 14.51 0.79 98.92
12 INT150949 Gene_expression of Fgfr1 6 0.63 5.71 0.57 98.92
13 INT92680 Gene_expression of Fgf2 59 0.77 28.11 8.12 98.92
14 INT80220 Positive_regulation of Bcl2 71 0.58 57.73 7.86 98.28
15 INT140858 Negative_regulation of SUGT1 9 0.05 8.41 1.4 98.12
16 INT228614 Negative_regulation of EXT1 1 0.58 0.86 0 97.48
17 INT210805 Negative_regulation of IHH 2 0.42 0.74 0.08 97.44
18 INT93361 Gene_expression of Trp53 208 0.78 175.35 16.65 96.96
19 INT97055 Positive_regulation of Gene_expression of Trp53 51 0.70 45.7 7.25 96.96
20 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98 93.44
21 INT167842 Positive_regulation of EXT1 5 0.50 2.88 0 91.12
22 INT228620 Transcription of EXT1 3 0.71 2.67 0 90.36
23 INT228617 Transcription of EXT2 1 0.69 1.56 0 90.00
24 INT166716 Negative_regulation of Ihh 3 0.43 0.67 0.33 90.00
25 INT228621 Positive_regulation of Gene_expression of EXT2 1 0.49 0.78 0 87.92
26 INT228619 Positive_regulation of EXT2 1 0.49 0.78 0 87.92
27 INT228612 Positive_regulation of Gene_expression of EXT1 2 0.50 1.48 0 87.92
28 INT228622 Positive_regulation of Transcription of EXT1 1 0.46 0.78 0 87.92
29 INT301359 Positive_regulation of Fgfr3 1 0.19 0.64 0 87.44
30 INT301355 Binding of Ext1 2 0.37 4.07 0.03 86.56
31 INT23635 Positive_regulation of MMP12 31 0.59 28.19 17.95 85.92
32 INT117440 Positive_regulation of Cdkn1a 3 0.67 2.95 0.4 82.88
33 INT301361 Phosphorylation of Cdkn1a 2 0.79 1.21 0.09 82.88
34 INT301362 Negative_regulation of Positive_regulation of Cdkn1a 1 0.41 0.39 0 82.88
35 INT62268 Positive_regulation of Cdkn1a 33 0.67 14.12 3.26 82.48
36 INT131018 Phosphorylation of Cdkn1a 3 0.61 2.06 0.4 82.48
37 INT172965 Negative_regulation of Positive_regulation of Cdkn1a 4 0.41 1.84 0 82.48
38 INT58192 Positive_regulation of MRI1 86 0.61 53.81 24.68 82.20
39 INT20492 Gene_expression of MMP12 89 0.76 81.36 46.12 81.80
40 INT176892 Binding of MR1 36 0.32 15.55 2.58 81.60
41 INT443 Localization of POMC 1020 0.81 284.52 443.17 79.84
42 INT163756 Phosphorylation of Stat1 45 0.82 14.51 6.11 79.44
43 INT189833 Negative_regulation of Phosphorylation of Stat1 4 0.51 1.1 0.3 79.44
44 INT85941 Binding of MMP12 3 0.31 4.91 1.12 77.36
45 INT105021 Binding of GOPC 187 0.40 60.39 20.38 76.64
46 INT80179 Negative_regulation of Arp 1 0.00 1 0.09 75.68
47 INT168370 Gene_expression of NPHS2 1 0.58 0.4 0.26 75.00
48 INT301357 Negative_regulation of Positive_regulation of Fgfr3 1 0.16 0.35 0 74.96
49 INT238768 Localization of BHLHE40 1 0.01 0.33 0 72.64
50 INT301354 Transcription of Ext1 1 0.46 1 0 71.24
51 INT177584 Gene_expression of MR1 80 0.58 46.48 5.48 69.36
52 INT70265 Regulation of MRI1 42 0.39 30.95 14.18 58.64
53 INT177593 Positive_regulation of Gene_expression of MR1 17 0.43 9.36 1.13 56.00
54 INT160622 Gene_expression of Pth1r 7 0.77 6.37 2 23.92
55 INT147079 Gene_expression of Ext2 2 0.66 1.04 0.1 13.44
56 INT301360 Gene_expression of Ext1 3 0.68 1.01 0 13.44
57 INT1878 Binding of HLA-B 440 0.48 321.16 127.36 5.00
58 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
59 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 5.00
60 INT180497 Binding of MRI1 45 0.42 28.35 14.77 5.00
61 INT952 Negative_regulation of GHRH 57 0.56 25.3 10.34 5.00
62 INT35584 Binding of ACLY 22 0.35 31.78 7.17 5.00
63 INT114295 Gene_expression of Gli2 10 0.54 7.58 2.95 5.00
64 INT100620 Localization of VIM 8 0.76 5.47 2.16 5.00
65 INT197791 Regulation of Pth1r 2 0.27 1.31 1.99 5.00
66 INT176888 Positive_regulation of MR1 29 0.67 11.68 1.71 5.00
67 INT121347 Binding of GNAS 8 0.13 3.99 1.47 5.00
68 INT197789 Regulation of Gene_expression of Pth1r 2 0.23 1.68 1.38 5.00
69 INT148562 Positive_regulation of GNAS 13 0.16 5.31 1.32 5.00
70 INT203640 Regulation of MR1 7 0.34 3.8 1.26 5.00
71 INT140983 Gene_expression of Ihh 7 0.78 2.06 1.15 5.00
72 INT71916 Gene_expression of TTN 9 0.75 1.69 0.97 5.00
73 INT167381 Localization of DES 4 0.73 4.15 0.77 5.00
74 INT148291 Positive_regulation of CSF3 9 0.61 6.37 0.7 5.00
75 INT177347 Positive_regulation of Gene_expression of Gli2 3 0.25 2.61 0.69 5.00
76 INT73226 Regulation of Vmo1 2 0.18 2.19 0.68 5.00
77 INT153257 Regulation of Ptch1 6 0.36 5.92 0.67 5.00
78 INT187087 Binding of Cd44 5 0.47 2.79 0.66 5.00
79 INT140984 Regulation of Ihh 5 0.54 2.81 0.56 5.00
80 INT178834 Localization of MR1 8 0.21 6.52 0.48 5.00
81 INT178830 Negative_regulation of MR1 16 0.50 7.63 0.44 5.00
82 INT42032 Localization of PNLIP 4 0.14 3.44 0.41 5.00
83 INT208157 Localization of LOC148709 2 0.73 0.52 0.2 5.00
84 INT197792 Regulation of Pthlh 3 0.24 2.47 0.18 5.00
85 INT113346 Binding of MDM2 10 0.35 5.73 0.15 5.00
86 INT274685 Localization of PROK2 3 0.42 0.31 0.08 5.00
87 INT274686 Phosphorylation of PNLIP 1 0.04 0.18 0.08 5.00
88 INT185284 Binding of CDK4 7 0.25 4.79 0.07 5.00
89 INT274684 Phosphorylation of HIST2H4A 1 0.12 0.18 0.05 5.00
90 INT274687 Phosphorylation of PROK2 1 0.06 0.17 0.05 5.00
91 INT272429 Positive_regulation of PROK2 2 0.32 0.24 0.03 5.00
92 INT210587 Binding of Pthlh 1 0.18 1.17 0.03 5.00
93 INT274683 Localization of HIST2H4A 5 0.12 1.54 0 5.00
94 INT197790 Gene_expression of Tmem150c 1 0.01 1.06 0 5.00
95 INT301356 Binding of Ihh 1 0.08 0.06 0 5.00
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