D:Osteogenesis Imperfecta

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Disease Term
Synonyms Brittle Bone, BRITTLE BONE DISEASE, Bruck Syndrome, Collagen Deficiency, Disease Lobstein, DISEASE LOBSTEIN S, Fragilitas Ossium, Lobstein Disease, LOBSTEIN S DISEASE, LOBSTEINS DISEASE, Ossiums Fragilitas
Documents 189
Hot Single Events 76
Hot Interactions 8

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Osteogenesis Imperfecta. They are ordered first by their relevance to Osteogenesis Imperfecta and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT59952 Gh Positive_regulation of IGF1 1 0.46 0.84 0.16 98.24
2 INT353392 Binding of DRD4 and NCK1 1 0.37 0.62 0.37 95.20
3 INT353391 Binding of DRD4 and GRB2 1 0.37 0.62 0.37 94.48
4 INT353390 Binding of DRD4 and SRC 1 0.25 0.62 0.37 94.00
5 INT255384 Binding of AKR1C2 and DSG1 1 0.01 1.54 0 93.68
6 INT332159 Gh Positive_regulation of Gene_expression of Igfbp3 1 0.07 1.11 0 89.40
7 INT344135 Negative_regulation of Binding of Col7a1 and Lhyp 1 0.00 0.5 0.13 89.40
8 INT344134 Binding of Col7a1 and Lhyp 1 0.00 0.5 0.13 88.20
9 INT182636 Binding of TNFSF11 and TNFRSF11A 16 0.29 17.5 0.84 52.64
10 INT209881 Binding of TNFRSF11B and TNFSF11 8 0.36 8.92 0.86 52.08
11 INT254434 Binding of Lrp5 and Best1 3 0.29 2.53 0 21.04
12 INT255385 Binding of COL1A2 and DSPP 1 0.40 0.12 0 7.52
13 INT173059 Binding of KDR and VEGFA 43 0.43 29.63 1.1 5.00
14 INT171990 Binding of DMD and VDR 5 0.05 2.58 0.39 5.00
15 INT254344 Binding of Col2a1 and Ncoa5 1 0.00 0.98 0.35 5.00
16 INT191718 Binding of FLT1 and VEGFA 35 0.50 12.18 0.27 5.00
17 INT257577 CALCA Positive_regulation of DMD 1 0.01 0.57 0.26 5.00
18 INT302978 Nqo1 Positive_regulation of Smpd2 1 0.01 1.1 0.22 5.00
19 INT302979 Binding of Gnb2l1 and Smpd2 1 0.07 0.71 0.09 5.00
20 INT302977 Binding of Cav1 and Smpd2 1 0.08 0.71 0.09 5.00
21 INT302980 Mmp2 Positive_regulation of Smpd3 1 0.29 0.78 0.05 5.00
22 INT302983 Fadd Positive_regulation of Casp3 1 0.15 1.13 0.04 5.00
23 INT302975 Fadd Positive_regulation of Bid 1 0.13 1.14 0.04 5.00
24 INT302982 Smpd1 Positive_regulation of Gene_expression of Smpd3 1 0.30 0.64 0.04 5.00
25 INT302981 Nqo1 Positive_regulation of Positive_regulation of Smpd2 1 0.00 0.45 0.04 5.00
26 INT302974 Nqo1 Positive_regulation of Jag2 1 0.00 0.45 0.04 5.00
27 INT205411 SORT1 Negative_regulation of TNFRSF9 1 0.10 0.23 0.03 5.00
28 INT254433 Binding of Lrp5 and Sost 2 0.39 1.51 0.03 5.00
29 INT205409 Binding of BMP6 and BMPR2 1 0.07 0.05 0 5.00
30 INT342385 Positive_regulation of Binding of Lrp5 and Vdr 1 0.53 0.98 0 5.00
31 INT354566 F2 Positive_regulation of PRNP 1 0.00 0.05 0 5.00
32 INT342387 Binding of CALCR and Car1 1 0.11 0.83 0 5.00
33 INT205452 Binding of BMP6 and Acvr2a 1 0.03 0.05 0 5.00
34 INT284370 Igf1 Regulation of Gene_expression of VEGFA 1 0.37 0.05 0 5.00
35 INT342378 Binding of Vdr and Best1 1 0.05 0.4 0 5.00
36 INT342383 Binding of Srp14 and Best1 1 0.00 0.56 0 5.00
37 INT205451 Binding of BMP2 and Acvr2a 1 0.02 0.05 0 5.00
38 INT254435 Binding of Esr1 and Best1 1 0.21 0.06 0 5.00
39 INT254432 Binding of Best1 and Sost 1 0.12 0.69 0 5.00
40 INT257589 Negative_regulation of Pth Positive_regulation of DMD 1 0.01 0 0 5.00
41 INT171991 Binding of DMD and ERAL1 1 0.01 0.54 0 5.00
42 INT205410 Binding of BMP2 and BMPR2 1 0.07 0.05 0 5.00
43 INT342381 Binding of Lrp5 and Vdr 1 0.55 0.97 0 5.00
44 INT257590 Pth Positive_regulation of DMD 2 0.02 0.44 0 5.00
45 INT342382 Binding of Car1 and Lrp5 1 0.40 0.9 0 5.00
46 INT342388 Binding of CALCR and Vdr 1 0.12 0.83 0 5.00
47 INT284366 Gopc Regulation of Vegfa 1 0.04 0 0 5.00
48 INT284368 ras Regulation of Transcription of VEGFA 1 0.14 0.1 0 5.00
49 INT342379 Binding of Car1 and Sugt1 1 0.01 0.83 0 5.00
50 INT284369 Igf1 Regulation of VEGFA 1 0.27 0.05 0 5.00
51 INT342386 Binding of CALCR and Best1 1 0.01 0.96 0 5.00
52 INT284371 ras Regulation of Gene_expression of VEGFA 1 0.06 0.1 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Osteogenesis Imperfecta. They are ordered first by their pain relevance and then by number of times they were reported in Osteogenesis Imperfecta. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT25123 Negative_regulation of COL7A1 42 0.58 19.98 5.96 100.00
2 INT84375 Regulation of COL1A2 6 0.44 8.75 1.72 99.96
3 INT53704 Negative_regulation of Col7a1 42 0.35 22.4 6.88 99.86
4 INT1498 Gene_expression of Gh 521 0.75 220.84 81.16 99.84
5 INT211970 Negative_regulation of Best1 49 0.14 37.33 2.32 99.84
6 INT158123 Negative_regulation of Gene_expression of COL5A2 19 0.46 15.27 2.23 99.84
7 INT158124 Gene_expression of COL5A2 136 0.69 72.3 12.44 99.84
8 INT65265 Positive_regulation of Gene_expression of Col7a1 48 0.69 23.81 6.16 99.82
9 INT234950 Binding of DSG1 29 0.36 23.67 0.69 99.76
10 INT9500 Negative_regulation of Ceacam1 26 0.58 6.89 3.91 99.66
11 INT81229 Binding of COL1A1 24 0.35 12.07 3.3 99.56
12 INT60710 Gene_expression of Col7a1 217 0.78 113.2 35.2 99.52
13 INT89520 Regulation of COL1A1 8 0.32 3.21 0.66 99.48
14 INT157805 Negative_regulation of Gene_expression of Col7a1 22 0.34 12.85 3.51 99.36
15 INT211969 Positive_regulation of Best1 34 0.11 14.92 1.44 99.28
16 INT5130 Regulation of GNRH1 139 0.62 31.95 42.08 99.16
17 INT1893 Localization of Gh 1041 0.79 340.23 256.58 99.12
18 INT17024 Gene_expression of COL1A2 69 0.77 36.38 8.29 99.08
19 INT61684 Localization of COL1A2 20 0.73 9.31 2.26 99.08
20 INT1530 Regulation of Gh 382 0.61 115.96 112.47 98.96
21 INT1221 Regulation of SGCG 65 0.60 24.21 22.94 98.96
22 INT302938 Gene_expression of Smpd3 1 0.78 16.18 1.17 98.82
23 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 98.78
24 INT22082 Localization of Ceacam1 13 0.80 2.44 2.48 98.74
25 INT65261 Regulation of Col7a1 18 0.55 8.7 1.33 98.32
26 INT211066 Negative_regulation of Positive_regulation of DMD 5 0.16 2.56 0.14 98.32
27 INT16166 Positive_regulation of DMD 348 0.67 133.22 15.06 97.84
28 INT5868 Positive_regulation of GNRH1 122 0.69 20.96 32.8 97.76
29 INT134966 Localization of Col7a1 23 0.42 16.4 5.24 97.76
30 INT187090 Positive_regulation of Localization of Col7a1 4 0.07 3.16 0.51 97.76
31 INT5865 Positive_regulation of Localization of Gh 282 0.69 84.86 93.5 97.56
32 INT211971 Binding of Best1 16 0.22 7.73 0.33 97.20
33 INT16167 Negative_regulation of DMD 186 0.57 108.71 15.25 97.08
34 INT13396 Gene_expression of DMD 125 0.75 57.81 5.45 97.08
35 INT1497 Negative_regulation of Gh 415 0.59 192.95 74.71 96.88
36 INT5135 Negative_regulation of GNRH1 106 0.58 36.63 27.71 96.16
37 INT112054 Negative_regulation of Negative_regulation of DMD 12 0.44 5.02 0.45 96.16
38 INT302952 Negative_regulation of Smpd3 1 0.43 2.57 0.22 95.92
39 INT38672 Binding of KRT20 69 0.39 48.01 6.31 95.64
40 INT234937 Localization of DSG1 5 0.66 4.14 0 95.44
41 INT65260 Positive_regulation of Col7a1 95 0.69 61.73 18.42 94.52
42 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 94.44
43 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 94.40
44 INT6624 Gene_expression of Pth 135 0.76 110.27 27.54 93.80
45 INT9118 Gene_expression of Ceacam1 37 0.75 17.19 6.12 93.80
46 INT15489 Negative_regulation of Gene_expression of SGCG 10 0.42 4.78 3.18 93.76
47 INT234962 Positive_regulation of Gene_expression of DSG1 5 0.48 5.41 0.37 93.44
48 INT140647 Gene_expression of DSG1 45 0.75 27.95 1.33 93.44
49 INT647 Gene_expression of SGCG 211 0.75 78.46 55.82 93.36
50 INT34777 Localization of IGF1 82 0.80 42.68 8.62 93.08
51 INT171998 Binding of DMD 58 0.47 38.13 3.35 92.60
52 INT259244 Negative_regulation of TNXB 1 0.42 2.15 0.13 92.56
53 INT8629 Positive_regulation of COL7A1 72 0.69 40.66 12.09 92.40
54 INT39911 Negative_regulation of Positive_regulation of Pth 5 0.41 2.57 0.37 91.88
55 INT703 Positive_regulation of Pth 177 0.70 127.09 27.26 90.76
56 INT19086 Negative_regulation of COL1A1 32 0.38 16.77 5.98 90.16
57 INT22083 Regulation of Pth 55 0.62 22.32 8.9 90.12
58 INT58566 Regulation of Gene_expression of Pth 5 0.58 2.3 0.38 90.12
59 INT22081 Regulation of Ceacam1 8 0.23 4.11 0.95 89.76
60 INT272178 Regulation of Gene_expression of Ceacam1 1 0.04 0.81 0 89.76
61 INT344131 Negative_regulation of Negative_regulation of Col7a1 1 0.02 0.49 0.12 89.40
62 INT234943 Phosphorylation of DSG1 2 0.48 1.81 0 89.32
63 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 88.32
64 INT89519 Negative_regulation of COL1A2 10 0.36 6.26 2.17 87.80
65 INT61068 Gene_expression of Igfbp3 15 0.75 8.48 1.41 87.76
66 INT302965 Regulation of Positive_regulation of Smpd3 1 0.27 0.78 0.03 87.24
67 INT302943 Regulation of Smpd3 1 0.45 1.35 0.03 87.24
68 INT3448 Positive_regulation of Gh 521 0.69 180.03 161.18 86.96
69 INT14559 Gene_expression of Igf1 254 0.78 112 34.17 86.80
70 INT302945 Positive_regulation of Smpd3 1 0.70 9.99 0.93 86.64
71 INT5006 Transcription of KRT20 9 0.46 7.11 1.03 84.64
72 INT9144 Localization of MSC 18 0.56 10.17 3.69 83.04
73 INT156097 Negative_regulation of Localization of VEGFA 70 0.58 34.96 4.17 82.68
74 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 82.36
75 INT48693 Regulation of VEGFA 268 0.62 191.88 31.52 82.08
76 INT302969 Positive_regulation of Positive_regulation of Smpd3 1 0.50 1.27 0.06 80.88
77 INT353393 Transcription of DRD4 1 0.63 0.57 0.27 78.72
78 INT167750 Positive_regulation of Gene_expression of DSPP 2 0.50 3.13 0 78.36
79 INT164066 Negative_regulation of SIL1 3 0.21 2.75 0.96 77.56
80 INT84704 Positive_regulation of Nqo1 18 0.70 18.64 5.65 75.80
81 INT302953 Positive_regulation of Smpd2 1 0.52 9.07 0.83 75.20
82 INT99690 Negative_regulation of Positive_regulation of VEGFA 30 0.58 14.56 4.79 75.20
83 INT17250 Negative_regulation of BGLAP 35 0.57 21 8.26 75.00
84 INT6516 Positive_regulation of BGLAP 45 0.67 26.61 9.9 75.00
85 INT743 Negative_regulation of Salpa1 16 0.57 8.75 3.1 75.00
86 INT232639 Positive_regulation of Jag2 4 0.14 10.63 1.03 74.92
87 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 74.84
88 INT202166 Positive_regulation of Clec2g 1 0.38 0.68 0 74.80
89 INT167751 Gene_expression of DSPP 15 0.77 8.56 0.24 73.80
90 INT205618 Gene_expression of Renbp 15 0.26 9.26 1.04 73.60
91 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 71.44
92 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 71.12
93 INT193312 Localization of DSPP 8 0.74 1.88 0.18 69.12
94 INT125005 Negative_regulation of SLPI 9 0.42 5.79 4.43 67.84
95 INT332156 Positive_regulation of Ppib 1 0.05 0.3 0 67.60
96 INT174106 Binding of Renbp 18 0.24 15.82 0.58 66.32
97 INT332157 Positive_regulation of Lepre1 1 0.17 0.3 0 66.16
98 INT170754 Localization of IFN1@ 121 0.78 66.78 15.6 66.08
99 INT4931 Localization of IFNG 53 0.78 33.25 13.65 66.08
100 INT332158 Positive_regulation of Crtap 1 0.49 0.3 0 65.68
101 INT48555 Binding of SP1 30 0.46 11.38 6.53 65.32
102 INT142082 Positive_regulation of IDO1 17 0.60 9.46 6.33 64.16
103 INT47371 Negative_regulation of ap 32 0.32 9.8 1.96 63.28
104 INT16180 Regulation of DSPP 6 0.53 4.63 0.28 62.72
105 INT4864 Regulation of BGLAP 22 0.34 10.8 5.07 62.16
106 INT9210 Regulation of IL6 166 0.62 125.61 49.95 58.40
107 INT111545 Phosphorylation of VEGFA 50 0.76 22.19 5.88 58.24
108 INT5973 Regulation of IL1B 109 0.62 66.6 39.88 57.60
109 INT137609 Localization of Vegfa 22 0.78 14.67 3.01 57.52
110 INT16165 Regulation of DMD 114 0.60 35.13 3.64 57.24
111 INT9660 Regulation of TNF 363 0.62 312.94 139.99 57.12
112 INT46483 Localization of Dpep1 4 0.06 1.58 0.88 56.52
113 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 54.32
114 INT101236 Gene_expression of LARGE 10 0.75 3.63 0.75 52.44
115 INT28122 Gene_expression of MSC 111 0.58 26.83 6.57 51.96
116 INT35269 Localization of SGCG 38 0.78 14.68 9.01 50.00
117 INT68681 Transcription of VEGFA 132 0.71 80.47 17.03 48.20
118 INT19775 Localization of Il1 183 0.78 145.5 50.91 47.68
119 INT129856 Positive_regulation of TNFRSF11A 26 0.68 16.21 4.75 45.04
120 INT302956 Localization of Smpd3 1 0.75 2.92 0.24 43.76
121 INT234940 Regulation of DSG1 2 0.21 2.29 0 31.92
122 INT68683 Regulation of Gene_expression of VEGFA 143 0.62 104.19 20.14 30.80
123 INT130867 Gene_expression of TNFSF11 106 0.77 45.15 10.34 25.24
124 INT157605 Localization of COL3A1 3 0.80 0.55 0.29 22.92
125 INT255387 Phosphorylation of DSPP 1 0.71 0 0 20.00
126 INT61466 Positive_regulation of Acp5 15 0.66 10.17 1.16 18.08
127 INT284359 Negative_regulation of Mvk 4 0.37 6.62 0.99 13.96
128 INT171995 Binding of PTH1R 8 0.35 1.16 0.31 9.84
129 INT89128 Binding of DSPP 7 0.32 2.24 0.98 7.92
130 INT302967 Localization of Smpd2 1 0.56 1.29 0.24 6.72
131 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
132 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 5.00
133 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
134 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 5.00
135 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
136 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 5.00
137 INT60694 Gene_expression of Il10 567 0.78 369.48 143.69 5.00
138 INT20374 Gene_expression of Il4 515 0.76 306.15 114.12 5.00
139 INT749 Gene_expression of HLA-B 341 0.75 224.12 77.37 5.00
140 INT60691 Gene_expression of Il12a 331 0.78 208.03 75.96 5.00
141 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92 5.00
142 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 5.00
143 INT170332 Gene_expression of IFN1@ 477 0.75 275.21 69.65 5.00
144 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34 5.00
145 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 5.00
146 INT11937 Localization of Il6 228 0.81 139.83 64.39 5.00
147 INT14740 Gene_expression of TGFB1 272 0.78 168.48 60.18 5.00
148 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87 5.00
149 INT46637 Gene_expression of CXCL10 172 0.78 121.94 57.74 5.00
150 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 5.00
151 INT63975 Positive_regulation of Il10 175 0.68 134.13 54.69 5.00
152 INT52264 Gene_expression of IK 180 0.77 90.87 51.87 5.00
153 INT16364 Gene_expression of HLA-DRA 234 0.78 118.81 45.01 5.00
154 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 5.00
155 INT100939 Gene_expression of Il13 176 0.73 125.1 43.38 5.00
156 INT65245 Gene_expression of Nos3 121 0.78 98.14 41.56 5.00
157 INT52732 Negative_regulation of CRP 169 0.59 138.47 40.33 5.00
158 INT63349 Gene_expression of PECAM1 199 0.75 166.03 36.76 5.00
159 INT1361 Negative_regulation of Gnrhr 118 0.58 57.77 35.54 5.00
160 INT326 Gene_expression of Gnrhr 105 0.76 35.87 34.93 5.00
161 INT20380 Gene_expression of Il5 172 0.78 104.75 34.78 5.00
162 INT7675 Gene_expression of ENG 146 0.77 45.35 34.6 5.00
163 INT67613 Positive_regulation of PPARG 94 0.70 69.15 34.38 5.00
164 INT11325 Gene_expression of HLA-E 209 0.76 98.05 33.72 5.00
165 INT11764 Positive_regulation of ENG 78 0.61 27.65 33.69 5.00
166 INT52350 Gene_expression of CD14 184 0.75 71.37 33.13 5.00
167 INT114881 Gene_expression of Akt1 227 0.78 102.49 31.81 5.00
168 INT29503 Gene_expression of Mmp2 95 0.77 56.92 31.68 5.00
169 INT35406 Localization of Tnf 94 0.81 64.63 31.65 5.00
170 INT13186 Positive_regulation of Il4 113 0.68 71.22 31.4 5.00
171 INT34729 Positive_regulation of IFN1@ 233 0.67 128.04 30.38 5.00
172 INT90792 Localization of Il10 144 0.80 87.88 30.03 5.00
173 INT10915 Gene_expression of ITGAM 164 0.78 92.42 29.78 5.00
174 INT15174 Gene_expression of Itgam 238 0.73 104.92 29.26 5.00
175 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 5.00
176 INT37296 Binding of Esr1 117 0.43 62.51 27.33 5.00
177 INT21687 Positive_regulation of ras 143 0.58 97.34 27.31 5.00
178 INT62710 Gene_expression of HGF 160 0.78 88.27 26.14 5.00
179 INT43486 Positive_regulation of Ifng 52 0.69 32.71 24.77 5.00
180 INT127435 Gene_expression of Per1 89 0.77 13.94 22.31 5.00
181 INT96156 Gene_expression of Cd40 144 0.77 56.95 21.7 5.00
182 INT48692 Binding of VEGFA 345 0.48 210.3 21.31 5.00
183 INT20379 Localization of Il4 85 0.73 51.22 20.55 5.00
184 INT86751 Negative_regulation of Il10 62 0.59 40.1 20.51 5.00
185 INT116282 Gene_expression of Mmp13 83 0.75 45.4 20.18 5.00
186 INT5398 Positive_regulation of ALPP 178 0.70 110.52 19.18 5.00
187 INT28215 Gene_expression of CDKN1A 196 0.76 113.9 18.3 5.00
188 INT2120 Gene_expression of CD79A 159 0.78 111.69 17.16 5.00
189 INT96155 Gene_expression of Cd86 134 0.77 50.56 17.13 5.00
190 INT12922 Gene_expression of Atp9a 115 0.75 50.95 17.01 5.00
191 INT197375 Gene_expression of Car1 84 0.65 16.46 16.45 5.00
192 INT22900 Positive_regulation of Cd4 126 0.67 82.77 16.43 5.00
193 INT56447 Positive_regulation of Icam1 64 0.64 64.14 16.16 5.00
194 INT170308 Gene_expression of Ido1 159 0.75 69.51 15.98 5.00
195 INT19963 Gene_expression of COL1A1 118 0.59 42.11 15.15 5.00
196 INT34590 Gene_expression of ALPP 199 0.75 89.85 15.1 5.00
197 INT1284 Negative_regulation of Mmp13 20 0.57 36.21 14.91 5.00
198 INT109535 Gene_expression of Vegfa 116 0.75 84.61 14.89 5.00
199 INT108480 Gene_expression of CCL21 53 0.77 37.87 14.42 5.00
200 INT78472 Gene_expression of CDKN2A 223 0.78 173.76 13.61 5.00
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