D:Osteogenic Sarcomas

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Disease Term
Synonyms BONE DISEASE, Bone Disorder, Bone Dysfunction, Bone Sarcoma, Bone Syndrome, Osteogenic Disease, Osteogenic Disorder, Osteogenic Dysfunction, Osteogenic Sarcoma, Osteogenic Sarcomata, OSTEOGENIC SYNDROME
Documents 684
Hot Single Events 200
Hot Interactions 28

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Osteogenic Sarcomas. They are ordered first by their relevance to Osteogenic Sarcomas and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT262226 Positive_regulation of Nr1i2 Positive_regulation of CYP3A4 1 0.17 0.68 0.12 100.00
2 INT262148 Positive_regulation of Nr1i2 Positive_regulation of Abcb1b 1 0.09 0.69 0.12 100.00
3 INT321221 Binding of FOSB and SIGLEC11 1 0.17 1.98 0 99.98
4 INT324899 Edn1 Positive_regulation of Positive_regulation of Mmp9 1 0.10 0.66 0.16 99.60
5 INT208152 Binding of CDK4 and MDM2 1 0.01 1.11 0 99.04
6 INT102805 NFKB1 Regulation of TCEAL1 1 0.25 0.77 0.17 97.76
7 INT102806 NFKB1 Regulation of Gene_expression of TCEAL1 1 0.25 0.77 0.17 97.76
8 INT102804 NFKB1 Regulation of TP53 1 0.35 0.77 0.17 97.76
9 INT102803 NFKB1 Regulation of Gene_expression of TP53 1 0.35 0.77 0.17 97.76
10 INT223963 Binding of Bglap and Runx2 1 0.14 1.74 0.13 97.16
11 INT297376 Binding of RARS and Rxra 1 0.01 3.27 0.24 96.12
12 INT297352 KLF2 Regulation of PPARA 1 0.12 1.31 0.35 95.36
13 INT301125 Tgm7 Regulation of Gene_expression of Cd34 1 0.40 1.29 0 95.20
14 INT318306 Binding of DPEP1 and NLRP3 1 0.03 1.77 0.15 94.96
15 INT318305 Binding of NOD2 and NLRP3 1 0.08 1.76 0.15 94.60
16 INT301131 Tgm7 Regulation of Gene_expression of VEGFA 1 0.03 1.29 0 94.48
17 INT290443 Gene_expression of TIMP2 Negative_regulation of MMP2 1 0.06 1.56 0.13 94.00
18 INT91456 IL1B Positive_regulation of Gene_expression of CPOX 6 0.17 3.36 1.53 93.40
19 INT262558 Phax Positive_regulation of Trpv1 1 0.01 1.26 1.92 92.92
20 INT302978 Nqo1 Positive_regulation of Smpd2 1 0.01 1.1 0.22 92.12
21 INT68557 ZNF697 Negative_regulation of PTGS1 1 0.02 0.59 0.33 92.08
22 INT339703 TRO Positive_regulation of Gene_expression of PPARA 1 0.21 0.33 0.03 90.64
23 INT217473 Nup62 Regulation of Tnfrsf11a 1 0.38 0.66 0 89.60
24 INT301130 Binding of VEGFA and Mmp2 1 0.03 1.33 0.03 88.72
25 INT121190 KCNMA1 Positive_regulation of Gene_expression of IL6 1 0.03 0.54 1.24 88.56
26 INT121189 KCNMA1 Positive_regulation of IL6 1 0.04 0.54 1.23 88.56
27 INT302164 PTEN Regulation of PIK3CD 1 0.16 1.13 0.06 85.80
28 INT352392 Binding of ENOSF1 and Recql4 1 0.02 6.62 0 80.56
29 INT227843 Binding of ERCC6 and MLL 1 0.00 0.34 0 79.36
30 INT342439 PPP2CA Negative_regulation of PRMT1 1 0.12 0.63 0 78.56
31 INT314370 Adipoq Positive_regulation of Tnfrsf11a 1 0.04 1.26 0.03 78.04
32 INT324894 Edn1 Positive_regulation of Gene_expression of Mmp3 1 0.07 0.66 0.16 76.32
33 INT301121 Tgm7 Regulation of Gene_expression of Mmp2 1 0.52 2.53 0.16 75.96
34 INT188436 Negative_regulation of NUP62 Positive_regulation of TNFRSF11A 1 0.39 1.6 0 75.16
35 INT301122 Tgm7 Negative_regulation of Akt1 1 0.38 2.78 0.07 75.00
36 INT227837 Positive_regulation of Binding of CSH1 and ERCC6 1 0.20 0.15 0 74.24
37 INT227832 Binding of CSH1 and ERCC6 1 0.15 0.15 0 74.24
38 INT290444 S100A4 Regulation of TIMP1 1 0.00 1.3 0.14 73.28
39 INT191718 Binding of FLT1 and VEGFA 35 0.50 12.18 0.27 73.04
40 INT352893 PTGDS Regulation of TP53 1 0.16 1.02 0.26 72.80
41 INT314369 Tnfsf11 Negative_regulation of Gene_expression of Tnfrsf11b 1 0.08 2.2 0.05 72.68
42 INT217487 Binding of PDB1 and Tnfrsf11a 1 0.03 0.76 0 72.48
43 INT173059 Binding of KDR and VEGFA 43 0.43 29.63 1.1 72.24
44 INT203638 Binding of MR1 and GOPC 1 0.04 1.43 0.05 72.16
45 INT339705 Regulation of Binding of FN1 and TRO 1 0.01 0.48 0.05 71.12
46 INT339698 Binding of FN1 and TRO 1 0.01 0.48 0.04 71.12
47 INT121188 Negative_regulation of KCNMA1 Positive_regulation of IL6 1 0.04 0.3 0.63 71.00
48 INT352931 Prkaca Regulation of TP53 1 0.13 1.01 0.26 70.00
49 INT352930 Prkaca Regulation of Phosphorylation of TP53 1 0.13 1.02 0.26 70.00
50 INT121191 KCNMA1 Positive_regulation of Phosphorylation of MAPK1 1 0.06 0.61 1.18 68.88
51 INT292454 Binding of BAD and BCL2 2 0.03 1.73 0 68.48
52 INT302137 Binding of BAD and BAK1 1 0.07 0.93 0 68.48
53 INT185856 Binding of BAD and BCL2L1 4 0.39 2.73 0 68.48
54 INT302172 Binding of BAD and BAX 1 0.06 0.93 0 68.48
55 INT302132 Negative_regulation of Binding of BAD and BAK1 1 0.06 0.93 0 68.48
56 INT258712 Binding of Gpd1 and Lipg 1 0.11 0.14 0 67.68
57 INT258725 Binding of GPD1 and Lipg 1 0.12 0.13 0 67.20
58 INT245073 VEGFA Positive_regulation of CXCR4 1 0.27 5.09 0 66.36
59 INT302980 Mmp2 Positive_regulation of Smpd3 1 0.29 0.78 0.05 65.00
60 INT232005 Binding of Cd36 and Tsp1 2 0.25 1.81 0.16 64.12
61 INT324900 VEGFA Positive_regulation of Gene_expression of Edn1 1 0.06 1.61 0.69 63.72
62 INT302145 Positive_regulation of AKT1 Positive_regulation of Phosphorylation of BAD 1 0.07 0.9 0 63.60
63 INT302983 Fadd Positive_regulation of Casp3 1 0.15 1.13 0.04 61.84
64 INT302975 Fadd Positive_regulation of Bid 1 0.13 1.14 0.04 61.84
65 INT217480 Tnfsf11 Negative_regulation of Tnfrsf11a 1 0.39 0.75 0 60.28
66 INT223965 Binding of AMY2A and Bglap 1 0.05 1.5 0.28 60.20
67 INT314373 Binding of Cd34 and Eng 1 0.08 0.9 0 58.08
68 INT314371 Binding of Cd34 and Thy1 1 0.08 0.9 0 58.08
69 INT325954 Binding of Cttn and Ezr 1 0.22 1.61 0.07 57.84
70 INT314374 Binding of Ptprc and Thy1 1 0.04 0.85 0 57.36
71 INT314372 Binding of Eng and Ptprc 1 0.04 0.84 0 57.36
72 INT302982 Smpd1 Positive_regulation of Gene_expression of Smpd3 1 0.30 0.64 0.04 51.04
73 INT301128 Binding of Tgm7 and Gm9662 1 0.01 0.12 0.04 50.00
74 INT301126 Tgm7 Regulation of Localization of Mmp2 1 0.38 0.2 0.03 50.00
75 INT301127 Tgm7 Regulation of Positive_regulation of Akt1 1 0.47 0.48 0 50.00
76 INT301129 Tgm7 Negative_regulation of Akt1 Negative_regulation of Localization of Mmp2 1 0.38 0.55 0 50.00
77 INT301124 Tgm7 Regulation of Akt1 1 0.40 0 0 50.00
78 INT301123 Tgm7 Regulation of Positive_regulation of Mmp2 1 0.23 1.47 0 50.00
79 INT262172 Nr1i2 Regulation of Msx2 1 0.12 0.53 0 49.12
80 INT270777 Binding of DMD and BPs 1 0.01 0.33 0.09 49.04
81 INT284370 Igf1 Regulation of Gene_expression of VEGFA 1 0.37 0.05 0 46.80
82 INT63391 SLTM Regulation of Gene_expression of Col2a1 1 0.00 0 0 46.36
83 INT284369 Igf1 Regulation of VEGFA 1 0.27 0.05 0 45.92
84 INT217478 Binding of Tnfrsf11a and Traf6 1 0.39 1.22 0.17 45.04
85 INT245076 CXCR4 Regulation of Gene_expression of VEGFA 1 0.16 1.05 0.03 45.00
86 INT262207 Binding of Nr1i2 and Ep300 1 0.14 1.08 0.11 43.48
87 INT262214 Binding of Msx2 and Nr1i2 1 0.19 0.55 0.06 43.48
88 INT262173 Binding of Msx2 and Ep300 1 0.07 0.55 0.06 43.04
89 INT121651 Binding of CXCL12 and CXCR4 13 0.48 17.61 3.52 42.84
90 INT338941 Binding of Ggh and Mtx1 1 0.30 0.47 0.27 38.72
91 INT330696 Phosphorylation of RB1 Positive_regulation of Gene_expression of E2F2 1 0.01 1 0 38.64
92 INT258714 Camk1g Positive_regulation of Gpd1 1 0.46 0.07 0.11 36.96
93 INT205158 Gene_expression of SPP1 Positive_regulation of Gene_expression of TNFSF11 1 0.11 1.08 0.08 36.80
94 INT217468 Positive_regulation of Binding of Nup62 and Mul1 1 0.16 0 0.05 34.96
95 INT262223 Negative_regulation of Nr1i2 Negative_regulation of Gene_expression of CYP3A4 1 0.21 0.48 0 33.28
96 INT217472 Binding of Nup62 and Mul1 1 0.12 0 0.05 31.36
97 INT324053 Binding of Banf1 and Lemd3 1 0.20 0.15 0 30.72
98 INT217471 Binding of Nup62 and Traf6 1 0.26 0 0.05 23.04
99 INT217467 Binding of Nup62 and Tnfrsf11a 1 0.31 0 0.05 22.32
100 INT227829 CFC1 Positive_regulation of Gene_expression of ERCC6 1 0.03 0 0 14.48
101 INT227833 Positive_regulation of CFC1 Positive_regulation of Gene_expression of ERCC6 1 0.03 0 0 14.48
102 INT236932 Binding of Rxra and Pprc1 1 0.00 0.45 0.07 13.84
103 INT352892 Binding of CAV1 and ITGA2 1 0.20 1.61 0.47 7.84
104 INT286420 Binding of Fgf13 and Mapk8ip3 1 0.36 0 0 7.76
105 INT171974 Binding of Tnfrsf11a and Tnfsf11 14 0.35 13.11 3.11 5.00
106 INT115367 Binding of IL6 and IL6R 12 0.07 8.16 2.36 5.00
107 INT93293 Ngf Regulation of Trpv1 2 0.28 0.71 1.9 5.00
108 INT183781 Binding of IL6 and INS 6 0.22 8.97 1.87 5.00
109 INT205152 Binding of CD44 and MMP9 23 0.35 17.13 1.85 5.00
110 INT241750 Binding of CD4 and ITIH4 14 0.18 5.72 1.53 5.00
111 INT121226 Ngf Regulation of Gene_expression of Trpv1 2 0.62 0.7 1.44 5.00
112 INT262568 Prkaca Regulation of Trpv1 2 0.10 0.65 1.38 5.00
113 INT113844 CDKN1A Negative_regulation of CDK2 4 0.49 1.18 1.27 5.00
114 INT55162 Binding of NFKB1 and RELA 10 0.30 2.82 1.18 5.00
115 INT230019 Binding of HLA-B and ERAL1 1 0.00 2.23 1.1 5.00
116 INT206074 Binding of IL6 and IL6ST 7 0.32 3.79 1.01 5.00
117 INT262165 Nr0b2 Negative_regulation of Nr5a2 1 0.02 0.5 0.92 5.00
118 INT209881 Binding of TNFRSF11B and TNFSF11 8 0.36 8.92 0.86 5.00
119 INT262572 Ngf Positive_regulation of Mapk1 2 0.04 0.52 0.81 5.00
120 INT262564 Ngf Positive_regulation of Pik3r1 1 0.08 0.36 0.8 5.00
121 INT262579 Ngf Positive_regulation of Prkca 1 0.07 0.36 0.8 5.00
122 INT262582 F2rl1 Regulation of Positive_regulation of Prkca 1 0.03 0.58 0.78 5.00
123 INT196525 Binding of MMP2 and MMP9 2 0.32 2.49 0.78 5.00
124 INT262562 F2rl1 Regulation of Trpv1 1 0.12 0.58 0.77 5.00
125 INT262563 Negative_regulation of Pax3 Regulation of Calca 1 0.01 0.75 0.76 5.00
126 INT262569 Pax3 Regulation of Calca 1 0.00 0.75 0.76 5.00
127 INT262577 Localization of Ngf Positive_regulation of Positive_regulation of Mapk14 1 0.05 0.92 0.75 5.00
128 INT262578 Prkaca Positive_regulation of Localization of Calca 1 0.03 0.71 0.75 5.00
129 INT262573 Par2 Regulation of Positive_regulation of Prkca 1 0.05 0.57 0.72 5.00
130 INT262580 Ngf Positive_regulation of Hspg2 1 0.03 0.35 0.72 5.00
131 INT262581 Prkca Positive_regulation of Phosphorylation of Trpv1 1 0.13 0.28 0.71 5.00
132 INT262574 Gnaq Positive_regulation of Prkca 1 0.00 0.57 0.71 5.00
133 INT262566 Par2 Regulation of Trpv1 1 0.20 0.57 0.71 5.00
134 INT262571 Phosphorylation of Trpv1 Positive_regulation of Localization of Calca 1 0.17 0.71 0.7 5.00
135 INT262570 Binding of Pax3 and Trpv1 1 0.02 1.05 0.67 5.00
136 INT255260 Binding of Cd47 and Tsp1 1 0.20 1.42 0.67 5.00
137 INT262576 Binding of Calca and Trpv1 1 0.13 1.05 0.66 5.00
138 INT64956 IRF6 Positive_regulation of Gene_expression of IL6 4 0.19 1.4 0.63 5.00
139 INT252869 Binding of Trpv1 and Phax 2 0.01 0.18 0.6 5.00
140 INT352891 Binding of ROS1 and GOPC 1 0.09 1.34 0.53 5.00
141 INT262565 Prkaca Regulation of Negative_regulation of Trpv1 1 0.05 0.21 0.5 5.00
142 INT327806 Binding of ADORA1 and ADORA2A 1 0.06 0.18 0.49 5.00
143 INT115186 IL6 Positive_regulation of Phosphorylation of STAT3 2 0.19 0.35 0.48 5.00
144 INT338940 Fpgs Positive_regulation of Mtx1 1 0.32 0.32 0.47 5.00
145 INT251297 Binding of C2 and CD4 1 0.04 0.35 0.47 5.00
146 INT262155 Nr5a2 Positive_regulation of Cyp7a1 1 0.07 0.24 0.45 5.00
147 INT269061 Binding of Il6 and Il6ra 3 0.04 2.59 0.45 5.00
148 INT262575 Trpv1 Positive_regulation of Prkca 1 0.13 0.17 0.44 5.00
149 INT262220 Positive_regulation of Nr1i2 Positive_regulation of Gene_expression of Abcc2 1 0.14 0.25 0.44 5.00
150 INT262186 Nr0b2 Positive_regulation of Negative_regulation of Cyp7a1 1 0.12 0.28 0.4 5.00
151 INT262205 Positive_regulation of Nr1i2 Positive_regulation of Gene_expression of Cyp3a11 1 0.33 0.11 0.38 5.00
152 INT262153 Binding of Clta and Nr1i2 1 0.05 0.65 0.38 5.00
153 INT300610 Rorb Regulation of Dnm2 1 0.01 0.27 0.37 5.00
154 INT300609 Binding of Ctnnb1 and Wnt2 1 0.02 0.25 0.37 5.00
155 INT300608 Arc Regulation of Dnm2 1 0.15 0.27 0.37 5.00
156 INT262182 Positive_regulation of Nr1i2 Negative_regulation of Gene_expression of Cyp7a1 1 0.23 0.36 0.36 5.00
157 INT262189 Binding of Nr1i2 and Nr1h4 1 0.14 0.18 0.36 5.00
158 INT172213 Binding of BAX and BCL2L1 3 0.22 4.02 0.35 5.00
159 INT133307 Binding of CD44 and SPP1 5 0.26 2.6 0.35 5.00
160 INT262218 Nr1h4 Regulation of Nr1i2 1 0.10 0.15 0.34 5.00
161 INT297351 EWSR1 Positive_regulation of PPARA 1 0.41 1.81 0.33 5.00
162 INT223962 Tnf Negative_regulation of Gene_expression of Bglap 1 0.21 1.21 0.32 5.00
163 INT223964 Tnf Negative_regulation of Bglap 1 0.21 1.2 0.32 5.00
164 INT324897 Binding of Ptbp1 and Il1 1 0.01 0.62 0.3 5.00
165 INT262208 Clta Positive_regulation of Nr1i2 1 0.09 0.59 0.29 5.00
166 INT352894 Negative_regulation of Binding of ROS1 and GOPC 1 0.08 0.67 0.28 5.00
167 INT216127 EGR1 Regulation of Transcription of TP53 1 0.06 0.21 0.28 5.00
168 INT262144 Nr1h4 Positive_regulation of Positive_regulation of Nr1i2 1 0.19 0.19 0.27 5.00
169 INT262194 Rhof Positive_regulation of Nr1i2 1 0.15 0.64 0.27 5.00
170 INT262164 Positive_regulation of Rhof Positive_regulation of Nr1i2 1 0.11 0.65 0.27 5.00
171 INT216128 EGR1 Regulation of TP53 1 0.11 0.21 0.27 5.00
172 INT352895 Positive_regulation of Binding of ROS1 and GOPC 1 0.08 0.68 0.26 5.00
173 INT257577 CALCA Positive_regulation of DMD 1 0.01 0.57 0.26 5.00
174 INT239226 Binding of Edn1 and Ednra 2 0.06 1.59 0.26 5.00
175 INT245072 PPARA Regulation of Gene_expression of CXCR4 1 0.07 0.68 0.26 5.00
176 INT262227 Nr1h4 Regulation of Transcription of CYP3A4 1 0.08 0.12 0.26 5.00
177 INT352890 Binding of PTGDS and ROS1 1 0.13 0.67 0.25 5.00
178 INT262202 Nr1i2 Regulation of Abcc2 1 0.19 0.12 0.25 5.00
179 INT262180 Nr1h4 Regulation of Sult2a1 1 0.11 0.11 0.25 5.00
180 INT262152 Nr1h4 Regulation of Abcc2 1 0.07 0.12 0.25 5.00
181 INT262200 Nr1i2 Regulation of Sult2a1 1 0.31 0.12 0.25 5.00
182 INT321224 TLR4 Positive_regulation of NFKB1 1 0.04 1.02 0.25 5.00
183 INT321223 CXCR1 Positive_regulation of NFKB1 1 0.00 1.02 0.25 5.00
184 INT262167 Binding of Nr1i2 and Nr0b2 1 0.15 0.11 0.25 5.00
185 INT302169 PTGER2 Positive_regulation of DYNC1LI1 1 0.02 1.51 0.25 5.00
186 INT262229 Binding of CYP3A4 and Casr 1 0.03 0.37 0.24 5.00
187 INT321222 Binding of NFKB1 and NFKBIZ 1 0.02 1.11 0.24 5.00
188 INT262179 Nr1i2 Regulation of Gene_expression of Nr0b2 1 0.09 0.07 0.24 5.00
189 INT262211 Nr1h4 Negative_regulation of Gene_expression of Cyp7a1 1 0.09 0.14 0.23 5.00
190 INT205155 Negative_regulation of Binding of CD44 and MMP9 1 0.32 1.98 0.23 5.00
191 INT262159 Positive_regulation of Nr1h4 Negative_regulation of Gene_expression of Cyp7a1 1 0.09 0.14 0.23 5.00
192 INT330976 Igh-Dex Positive_regulation of Gene_expression of VDR 1 0.01 1.11 0.23 5.00
193 INT262151 Vdr Regulation of Cyp24a1 1 0.24 0.24 0.23 5.00
194 INT302170 PTGER2 Positive_regulation of Gene_expression of BCL2 1 0.04 3.76 0.23 5.00
195 INT255261 Tsp1 Positive_regulation of Binding of Cd47 1 0.27 0.5 0.23 5.00
196 INT262178 Binding of Nr1i2 and Abcb1b 1 0.07 1.68 0.21 5.00
197 INT255257 Binding of Serpine1 and Tsp1 1 0.07 0.85 0.2 5.00
198 INT262210 Negative_regulation of Nr1i2 Negative_regulation of Positive_regulation of Cyp3a11 1 0.31 0.4 0.2 5.00
199 INT287894 VEGFA Positive_regulation of Localization of BMP4 1 0.04 2.49 0.2 5.00
200 INT255259 Binding of Plg and Tsp1 1 0.05 0.84 0.2 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Osteogenic Sarcomas. They are ordered first by their pain relevance and then by number of times they were reported in Osteogenic Sarcomas. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT43160 Gene_expression of EOS 3 0.65 5.03 0.81 100.00
2 INT129901 Gene_expression of Nr1i2 60 0.73 22.44 6.04 100.00
3 INT71557 Gene_expression of Ccng1 5 0.77 3.65 0.41 100.00
4 INT142120 Gene_expression of Runx2 45 0.77 15.76 2.55 100.00
5 INT97674 Positive_regulation of Localization of Calca 70 0.69 27.71 51.79 100.00
6 INT145515 Positive_regulation of Localization of Trpv1 23 0.50 10.12 12.08 100.00
7 INT5008 Localization of Calca 204 0.81 80.35 125.16 100.00
8 INT96622 Localization of Trpv1 110 0.81 59.82 63.25 100.00
9 INT297368 Regulation of Positive_regulation of VDR 1 0.27 1.66 0 100.00
10 INT71559 Gene_expression of Ccng1 3 0.09 2.58 0.3 100.00
11 INT208507 Binding of EOS 2 0.10 2.42 0 100.00
12 INT5379 Gene_expression of Fos 656 0.78 255.5 292.54 100.00
13 INT134663 Gene_expression of SOX9 40 0.75 9.07 1.2 100.00
14 INT108790 Gene_expression of RGS1 2 0.58 4.36 1.76 100.00
15 INT145514 Localization of Nefh 5 0.32 2.23 0.72 100.00
16 INT286372 Gene_expression of Zmym4 1 0.73 0.28 0 100.00
17 INT5847 Transcription of FOS 31 0.69 11.11 6.41 100.00
18 INT208928 Localization of Myb 2 0.64 0.2 0 100.00
19 INT11277 Localization of Fos 22 0.78 6.58 4.19 100.00
20 INT136982 Positive_regulation of Positive_regulation of Nr1i2 3 0.65 4.66 2.89 100.00
21 INT240593 Gene_expression of Naip1 1 0.02 2.01 0.49 100.00
22 INT223459 Gene_expression of Dock4 2 0.71 1.5 0.16 100.00
23 INT286413 Gene_expression of Usp36 1 0.71 0.18 0 100.00
24 INT63074 Gene_expression of FOSB 19 0.53 13.58 4.91 100.00
25 INT90621 Positive_regulation of Gene_expression of FOSB 3 0.34 2.85 0.83 100.00
26 INT168801 Localization of Egr1 4 0.78 0.7 0.48 100.00
27 INT244913 Regulation of Transcription of FOS 2 0.10 1.09 0.28 100.00
28 INT207067 Localization of Akt2 2 0.69 0.59 0.04 100.00
29 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 99.96
30 INT86295 Gene_expression of Mmp2 114 0.76 73.68 24.25 99.96
31 INT122901 Positive_regulation of Spp1 67 0.67 58.03 7.49 99.86
32 INT3823 Positive_regulation of ALPI 27 0.69 19.49 2.15 99.86
33 INT123458 Positive_regulation of Tnfrsf11b 9 0.43 14.3 2.01 99.86
34 INT242988 Positive_regulation of Transcription of Spp1 4 0.28 3.28 0.92 99.86
35 INT262109 Positive_regulation of Mgp 2 0.63 42.44 0.9 99.86
36 INT262051 Positive_regulation of Transcription of Mgp 1 0.11 0.7 0 99.86
37 INT262124 Positive_regulation of Transcription of Tnfrsf11b 1 0.07 0.69 0 99.86
38 INT8962 Gene_expression of Cpe 110 0.71 39.67 71.67 99.84
39 INT155490 Binding of Mki67 13 0.19 13.38 0.41 99.84
40 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32 99.84
41 INT102639 Positive_regulation of VDR 31 0.69 18.05 2.38 99.84
42 INT114246 Positive_regulation of Negative_regulation of EGFR 13 0.49 8.67 0.7 99.84
43 INT67275 Gene_expression of L2 6 0.66 1.9 2.63 99.84
44 INT223959 Localization of Bglap 10 0.77 11.25 1.74 99.84
45 INT55952 Transcription of TP53 16 0.61 12.14 2.36 99.82
46 INT250698 Positive_regulation of Transcription of TP53 3 0.18 3.68 0 99.82
47 INT79060 Gene_expression of NOS2 116 0.78 69.25 34.84 99.80
48 INT79061 Positive_regulation of NOS2 92 0.65 58.89 23.96 99.80
49 INT2699 Binding of Cpe 40 0.48 7.07 33.64 99.80
50 INT6852 Localization of TNF 883 0.81 705.95 270.84 99.76
51 INT6849 Localization of IL1B 229 0.81 112.56 69.63 99.76
52 INT19189 Localization of IL1A 14 0.78 9.02 3.78 99.76
53 INT33936 Positive_regulation of ARID3B 1 0.28 0.83 0.07 99.76
54 INT22211 Positive_regulation of CYP3A4 110 0.70 22 28.27 99.76
55 INT147162 Positive_regulation of Abcb1b 13 0.57 7.29 1.15 99.76
56 INT102638 Regulation of VDR 21 0.44 9.92 2.54 99.74
57 INT50077 Gene_expression of Myb 21 0.66 7.68 1.54 99.72
58 INT221419 Regulation of BRCA1 5 0.35 6.18 0.31 99.70
59 INT94164 Phosphorylation of RB1 83 0.80 48.84 3.21 99.70
60 INT119700 Gene_expression of VDR 88 0.75 65.33 11.5 99.64
61 INT182968 Positive_regulation of Gene_expression of VDR 22 0.58 15.22 0.89 99.64
62 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51 99.62
63 INT285 Positive_regulation of Salpa1 73 0.68 61.47 9.19 99.60
64 INT89118 Protein_catabolism of MIB1 1 0.26 1.18 0.12 99.60
65 INT176489 Gene_expression of MCAM 18 0.68 3.92 0.78 99.60
66 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 99.60
67 INT55583 Localization of IFNA1 135 0.78 85.07 24.13 99.60
68 INT115384 Positive_regulation of Mmp9 121 0.68 94.74 43.02 99.60
69 INT88322 Gene_expression of CCR5 111 0.78 77.36 39.84 99.60
70 INT312023 Regulation of Gene_expression of MCAM 2 0.54 0.34 0.13 99.60
71 INT39153 Positive_regulation of PTGS2 182 0.70 96.16 60.6 99.56
72 INT325930 Gene_expression of Ezr 75 0.77 59.77 4.06 99.56
73 INT17848 Binding of PTGS2 70 0.46 32.1 20.6 99.56
74 INT325940 Positive_regulation of Gene_expression of Ezr 42 0.69 27.79 1.56 99.56
75 INT62124 Gene_expression of NOS1 444 0.78 218.08 114.85 99.56
76 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 99.56
77 INT176513 Transcription of Spp1 5 0.63 4.32 0.67 99.56
78 INT209397 Transcription of ALPI 2 0.55 1.18 0.24 99.56
79 INT262083 Transcription of Mgp 1 0.12 0.69 0 99.56
80 INT262055 Transcription of Tnfrsf11b 1 0.11 0.69 0 99.56
81 INT8413 Gene_expression of Ptgs1 248 0.78 110.17 108.58 99.52
82 INT15246 Regulation of FOS 32 0.60 15.34 12.94 99.50
83 INT15450 Positive_regulation of Gene_expression of Cpe 11 0.34 4.53 4.34 99.48
84 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 99.46
85 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71 99.44
86 INT59987 Gene_expression of BDKRB1 25 0.77 11.95 15.93 99.44
87 INT223949 Transcription of Bglap 1 0.68 19.96 3.98 99.44
88 INT84685 Regulation of BCL2 67 0.60 72.96 6.65 99.44
89 INT6848 Gene_expression of BDKRB2 40 0.75 17.19 20.04 99.44
90 INT39188 Gene_expression of IGKV5-2 22 0.38 10.95 9.91 99.44
91 INT73262 Negative_regulation of BCL2 67 0.57 61.01 5.07 99.44
92 INT110343 Negative_regulation of PIK3CD 22 0.40 5.84 4.2 99.44
93 INT223958 Positive_regulation of Transcription of Bglap 1 0.66 6.57 1.19 99.44
94 INT116464 Negative_regulation of Birc5 53 0.59 45.4 4.91 99.44
95 INT182318 Regulation of Birc5 25 0.60 23.58 2.29 99.44
96 INT302261 Regulation of PIK3CD 7 0.29 5.34 0.15 99.44
97 INT222961 Negative_regulation of Binding of PPARA 22 0.41 10.76 2.72 99.40
98 INT5114 Gene_expression of Ptgis 41 0.50 21.43 8.1 99.40
99 INT100620 Localization of VIM 8 0.76 5.47 2.16 99.38
100 INT187418 Positive_regulation of Gene_expression of MTTP 5 0.18 4.83 0.76 99.36
101 INT40369 Gene_expression of LRP5 8 0.55 5.63 0.74 99.36
102 INT9196 Gene_expression of PTGS1 215 0.77 96.99 60.5 99.34
103 INT55135 Positive_regulation of Gene_expression of PTGS2 137 0.70 80.32 38.46 99.34
104 INT50670 Gene_expression of CPOX 763 0.76 442.13 195.02 99.32
105 INT10837 Positive_regulation of Gene_expression of IL8 294 0.70 190.08 70.34 99.32
106 INT136981 Positive_regulation of Gene_expression of Nr1i2 2 0.65 3.63 1.34 99.32
107 INT57692 Positive_regulation of Gene_expression of Il1b 50 0.67 43.54 28.29 99.32
108 INT15769 Gene_expression of Il1b 146 0.78 114.51 75.35 99.32
109 INT265573 Positive_regulation of Gene_expression of Msc 4 0.41 6.78 0.12 99.32
110 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 99.30
111 INT81982 Gene_expression of Bmpr2 36 0.60 14.58 1.55 99.28
112 INT219929 Positive_regulation of Gene_expression of Bmpr2 3 0.15 0.9 0 99.28
113 INT47704 Regulation of Egr1 17 0.60 2.43 5.18 99.28
114 INT286406 Localization of Usp36 1 0.68 0.1 0 99.26
115 INT102814 Negative_regulation of CASP3 46 0.43 28.54 6.94 99.24
116 INT73266 Gene_expression of RB1 50 0.70 29.09 2.31 99.20
117 INT50814 Positive_regulation of Mmp2 72 0.68 51.37 20.42 99.20
118 INT71556 Positive_regulation of Gene_expression of Ccng1 1 0.50 1.66 0.19 99.20
119 INT1438 Localization of Pomc 360 0.81 101.26 116.47 99.20
120 INT167381 Localization of DES 4 0.73 4.15 0.77 99.18
121 INT208157 Localization of LOC148709 2 0.73 0.52 0.2 99.18
122 INT203491 Gene_expression of Msc 40 0.64 36.05 1.35 99.12
123 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 99.12
124 INT93664 Gene_expression of TIMP2 33 0.67 36.67 7.14 99.12
125 INT52457 Gene_expression of ABCB1 129 0.78 38.68 19.88 99.08
126 INT95971 Negative_regulation of Gene_expression of ABCB1 7 0.58 5.61 3.34 99.08
127 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19 99.06
128 INT756 Gene_expression of C3 138 0.75 100.6 19.2 99.06
129 INT107605 Gene_expression of MMP14 26 0.64 25.88 4.49 99.06
130 INT69723 Gene_expression of SERPINB2 7 0.60 4.54 1.28 99.06
131 INT124774 Binding of Vcp 4 0.44 3.4 0.52 99.06
132 INT240602 Gene_expression of RIPK1 2 0.58 0.69 0.16 99.06
133 INT48075 Positive_regulation of Il1b 71 0.67 48.63 40.48 99.04
134 INT113346 Binding of MDM2 10 0.35 5.73 0.15 99.04
135 INT185284 Binding of CDK4 7 0.25 4.79 0.07 99.04
136 INT5398 Positive_regulation of ALPP 178 0.70 110.52 19.18 99.00
137 INT95669 Regulation of TNFRSF11A 7 0.56 10.01 0.94 99.00
138 INT302229 Negative_regulation of Negative_regulation of BCL2 3 0.21 2.69 0.04 98.98
139 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 98.92
140 INT86024 Gene_expression of PPARA 736 0.78 497.93 91.14 98.88
141 INT201962 Transcription of Bmpr2 6 0.37 3.51 0.09 98.88
142 INT108556 Negative_regulation of BCL2L10 8 0.32 7.77 1.49 98.88
143 INT141344 Transcription of Egr1 11 0.70 5.59 1.34 98.88
144 INT123131 Negative_regulation of Negative_regulation of AKT1 6 0.42 3.23 0.58 98.88
145 INT258044 Regulation of BCL2L10 3 0.34 2.26 0.04 98.88
146 INT103094 Binding of PPARA 308 0.47 177.26 34.75 98.84
147 INT96917 Positive_regulation of Mapk14 261 0.70 173.29 88.79 98.80
148 INT121943 Positive_regulation of Nr1i2 64 0.68 19.22 8.39 98.80
149 INT152894 Regulation of Positive_regulation of Mapk14 9 0.45 6.01 1.74 98.80
150 INT88318 Gene_expression of CXCR4 208 0.77 189.67 31.72 98.72
151 INT5539 Negative_regulation of Mme 75 0.59 28.91 41.84 98.72
152 INT232510 Negative_regulation of Gene_expression of CXCR4 18 0.58 20.27 2.54 98.72
153 INT63390 Regulation of Gene_expression of SGCG 2 0.44 0.69 1.21 98.72
154 INT22449 Regulation of SLTM 2 0.04 0.65 0.76 98.72
155 INT37617 Regulation of Gene_expression of Col2a1 3 0.31 1.48 0.7 98.72
156 INT150165 Gene_expression of MTTP 21 0.75 10.1 0.73 98.68
157 INT73048 Gene_expression of MMP9 268 0.77 159.75 57.81 98.64
158 INT103245 Positive_regulation of Gene_expression of MMP9 64 0.68 36.86 15.7 98.64
159 INT21533 Positive_regulation of Il1f5 7 0.25 4.78 2.77 98.64
160 INT297364 Positive_regulation of KLF2 1 0.18 1.24 0.34 98.60
161 INT277140 Positive_regulation of Positive_regulation of Mki67 1 0.11 0.5 0 98.60
162 INT67614 Positive_regulation of PPARA 438 0.68 293.28 63.61 98.60
163 INT100046 Gene_expression of BTG2 16 0.20 10.81 1.95 98.56
164 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 98.48
165 INT232921 Gene_expression of Krt6b 2 0.65 1.5 0 98.48
166 INT56749 Gene_expression of PCNA 219 0.77 111.25 18.42 98.44
167 INT96911 Positive_regulation of Phosphorylation of Mapk14 46 0.70 43.03 15.15 98.44
168 INT121942 Binding of Nr1i2 2 0.45 15.69 3.66 98.44
169 INT71558 Positive_regulation of Gene_expression of Ccng1 1 0.00 0.71 0.1 98.44
170 INT6364 Gene_expression of Edn1 123 0.78 73.76 28.43 98.44
171 INT142123 Positive_regulation of Gene_expression of Runx2 17 0.64 4.81 0.65 98.40
172 INT342450 Positive_regulation of PPP2CA 1 0.15 1.07 0 98.32
173 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 98.28
174 INT79270 Gene_expression of MKI67 113 0.77 63.52 3.38 98.24
175 INT75504 Gene_expression of CDK4 9 0.72 7.43 0.3 98.20
176 INT175002 Positive_regulation of Mki67 10 0.31 5.7 0.26 98.20
177 INT85943 Negative_regulation of Nos2 161 0.59 108.56 42.65 98.16
178 INT144392 Negative_regulation of Negative_regulation of Nos2 2 0.42 1.83 1.24 98.16
179 INT95670 Regulation of PDB1 4 0.60 5.59 0.55 98.08
180 INT117113 Regulation of Mapk14 28 0.45 16.71 11.99 98.08
181 INT11346 Binding of Mtx1 39 0.41 24.88 21.21 98.08
182 INT27268 Localization of Gtf3a 71 0.21 56.93 12.51 98.02
183 INT65684 Gene_expression of MDM2 30 0.62 24.94 1.55 97.96
184 INT96914 Phosphorylation of Mapk14 168 0.82 108.46 53.32 97.96
185 INT207433 Positive_regulation of MTTP 5 0.14 2.47 0.08 97.96
186 INT68445 Gene_expression of ENPP1 10 0.70 10.8 3.3 97.96
187 INT172001 Gene_expression of ANKH 2 0.38 11.92 3.12 97.96
188 INT12915 Gene_expression of MGP 18 0.75 7.53 4.15 97.96
189 INT95668 Positive_regulation of Tnfrsf11a 12 0.47 10.14 1.34 97.80
190 INT34592 Positive_regulation of Gene_expression of ALPP 51 0.67 20.62 5.68 97.76
191 INT102813 Regulation of Gene_expression of TP53 25 0.59 25.95 0.75 97.76
192 INT179227 Positive_regulation of Crisp1 3 0.45 1.15 0.3 97.76
193 INT281988 Positive_regulation of Gene_expression of Crisp1 1 0.06 0.5 0.1 97.76
194 INT163832 Negative_regulation of Gene_expression of EGFR 50 0.59 39.71 3.45 97.72
195 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 97.72
196 INT71555 Negative_regulation of Gene_expression of Ccng1 2 0.58 1.53 0.14 97.72
197 INT188255 Gene_expression of DKK1 19 0.60 12.69 2.39 97.72
198 INT51028 Regulation of Il1b 28 0.60 21.15 12.47 97.68
199 INT89395 Negative_regulation of AKT1 127 0.58 70.27 12.54 97.64
200 INT312025 Regulation of Gene_expression of THY1 1 0.16 0.51 0.13 97.64
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