D:Osteolysis

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Disease Term
Synonyms Osteolyses
Documents 828
Hot Single Events 200
Hot Interactions 28

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Osteolysis. They are ordered first by their relevance to Osteolysis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT89475 TGFB1 Positive_regulation of Gene_expression of PTHLH 3 0.61 3.64 0.21 100.00
2 INT210598 PTHLH Positive_regulation of Gene_expression of TNFSF11 1 0.23 0.98 0.04 100.00
3 INT343544 Negative_regulation of GLI2 Negative_regulation of Gene_expression of PTHLH 1 0.24 0.53 0.03 99.80
4 INT217486 Binding of PDB1 and Sqstm1 1 0.03 1.19 0.08 98.46
5 INT245111 MMP9 Positive_regulation of Localization of Gtf3a 1 0.00 0.99 0 98.44
6 INT220456 Binding of VCAN and BAG6 1 0.01 3.46 0 98.40
7 INT107910 Binding of Tnfrsf11b and Tnfsf11 6 0.30 5.88 0.7 98.08
8 INT107909 Binding of Tnfsf11 and Tnfrsf22 1 0.01 2.12 0.11 96.88
9 INT188436 Negative_regulation of NUP62 Positive_regulation of TNFRSF11A 1 0.39 1.6 0 95.84
10 INT343546 Negative_regulation of ROCK1 Negative_regulation of Gene_expression of PTHLH 1 0.16 3.28 0.03 95.40
11 INT293412 GOPC Regulation of Localization of VEGFA 1 0.04 0.61 0 94.76
12 INT293413 GOPC Regulation of Localization of IL11 1 0.03 0.6 0 94.40
13 INT210600 IL1B Regulation of TNFSF11 1 0.04 1.45 0.08 93.36
14 INT210599 IL8 Regulation of TNFSF11 1 0.05 1.44 0.08 92.96
15 INT343545 Binding of GLI2 and ROCK1 1 0.07 0.65 0.03 88.88
16 INT208572 Binding of IL8 and CXCR1 6 0.33 5.2 3.08 88.48
17 INT210601 IL8 Positive_regulation of TNFSF11 1 0.06 1.46 0.08 88.48
18 INT293408 HRAS Regulation of VEGFA 1 0.00 1.18 0.1 87.52
19 INT293409 IL8 Regulation of VEGFA 1 0.04 1.18 0.1 87.52
20 INT293416 IL8 Regulation of PTHLH 1 0.04 1.18 0.1 87.28
21 INT293414 HRAS Regulation of PTHLH 1 0.00 1.18 0.1 87.28
22 INT210597 Negative_regulation of Binding of TNFSF11 and TNFRSF11A 3 0.26 5.66 0.33 86.96
23 INT293411 IL8 Regulation of IL11 1 0.03 1.17 0.1 86.84
24 INT293417 HRAS Regulation of IL11 1 0.00 1.17 0.1 86.84
25 INT245110 Binding of MMP9 and Mmp9 1 0.08 1.53 0 86.16
26 INT182636 Binding of TNFSF11 and TNFRSF11A 16 0.29 17.5 0.84 86.12
27 INT210595 Binding of TNF and TNFSF11 1 0.10 5.13 0.09 85.20
28 INT341666 ALPI Positive_regulation of ENPEP 1 0.01 1.05 0 82.48
29 INT245103 TNFRSF11B Negative_regulation of MMP14 1 0.02 1.15 0 79.56
30 INT220460 VEGFA Regulation of BAG6 1 0.02 1.28 0 78.48
31 INT220462 VEGFA Regulation of FN1 1 0.05 1.28 0 77.84
32 INT171974 Binding of Tnfrsf11a and Tnfsf11 14 0.35 13.11 3.11 76.88
33 INT89477 PTHLH Negative_regulation of Gene_expression of TNFRSF11B 1 0.14 0.15 0 72.48
34 INT293415 HRAS Positive_regulation of Localization of IL8 1 0.01 0.73 0.09 68.80
35 INT280276 Binding of Tgfb1 and Positive_regulation of VEGFA 1 0.02 1.27 0 65.76
36 INT280262 Binding of Tgfb1 and Positive_regulation of Cxcr4 1 0.07 1.27 0 65.20
37 INT334061 Negative_regulation of Binding of TNFRSF11A and Tnfsf11 1 0.01 0.52 0.08 63.80
38 INT295005 Binding of TNFRSF11A and Tnfsf11 3 0.20 2.02 0.09 63.44
39 INT172125 Binding of Tnfrsf11b and Tnfrsf11a 2 0.17 2.12 0.39 59.20
40 INT89474 TGFB1 Positive_regulation of ESR1 Positive_regulation of ESR1 1 0.18 0.11 0 56.64
41 INT220459 Binding of FN1 and VEGFA 1 0.09 1.45 0.05 54.48
42 INT217478 Binding of Tnfrsf11a and Traf6 1 0.39 1.22 0.17 52.76
43 INT210596 TNFRSF11B Negative_regulation of Binding of TNFSF11 2 0.11 1.62 0.04 50.00
44 INT210594 TNFRSF11B Negative_regulation of Binding of TNFRSF11A 1 0.15 0.77 0.04 50.00
45 INT210593 TNFRSF11B Negative_regulation of Binding of TNFSF11 and TNFRSF11A 2 0.10 1.62 0.04 50.00
46 INT220457 Binding of VCAN and FN1 1 0.02 0.93 0.04 45.32
47 INT355364 Regulation of PTHLH Positive_regulation of Tnfsf11 1 0.04 1.51 0.19 44.64
48 INT355366 Regulation of CSF1 Positive_regulation of Tnfsf11 1 0.02 1.5 0.19 44.64
49 INT302311 PTH Negative_regulation of Gene_expression of SOST 1 0.29 0.59 0 44.44
50 INT355365 CSF1 Positive_regulation of Tnfsf11 1 0.03 1.49 0.19 41.68
51 INT355363 PTHLH Positive_regulation of Tnfsf11 1 0.04 1.47 0.19 36.72
52 INT225268 Negative_regulation of S100a7a Negative_regulation of Gene_expression of VEGFA 1 0.01 0.24 0 36.08
53 INT225267 Gene_expression of S100a7a Positive_regulation of Gene_expression of VEGFA 1 0.01 0.23 0 29.84
54 INT225265 Gene_expression of S100a7a Positive_regulation of VEGFA 1 0.01 0.23 0 28.96
55 INT220458 Binding of VCAN and SELP 1 0.01 1.15 0.05 28.60
56 INT307100 Trpv1 Regulation of Binding of Trpa1 1 0.31 1.81 0.97 28.44
57 INT307103 Trpa1 Regulation of Binding of Trpv1 1 0.31 1.81 0.97 28.44
58 INT180956 PLG Regulation of Positive_regulation of MMP13 1 0.32 0.38 0.04 26.96
59 INT180957 Binding of PLG and Regulation of Positive_regulation of MMP13 1 0.14 0.38 0.04 26.96
60 INT180955 PLG Regulation of Positive_regulation of TIMP1 1 0.21 0.38 0.04 26.32
61 INT171976 Il18 Positive_regulation of Gene_expression of IFNA1 1 0.01 1.37 0.64 5.12
62 INT145775 Ngf Positive_regulation of Trpv1 11 0.72 7.71 11.25 5.00
63 INT258798 Binding of NR3C1 and HSP90AA1 1 0.01 1.09 0.78 5.00
64 INT180961 Binding of MOCS1 and PLAU 1 0.00 0.61 0.67 5.00
65 INT180958 Binding of F13A1 and PLAT 2 0.03 2.16 0.47 5.00
66 INT311997 Regulation of STAM Regulation of BGLAP 1 0.00 0.61 0.32 5.00
67 INT311991 STAM Regulation of BGLAP 1 0.00 0.61 0.31 5.00
68 INT180964 PLG Positive_regulation of MMP13 1 0.24 0.45 0.25 5.00
69 INT171973 Tnfsf11 Positive_regulation of Gene_expression of Il1 1 0.06 0.21 0.21 5.00
70 INT171972 Tnfsf11 Positive_regulation of Gene_expression of Il6 1 0.08 0.21 0.21 5.00
71 INT343547 ROCK1 Positive_regulation of Gene_expression of PTHLH 1 0.15 0.2 0.2 5.00
72 INT280260 Tgfb1 Positive_regulation of Cxcr1 1 0.07 1.78 0.19 5.00
73 INT280270 Tgfb1 Positive_regulation of Gene_expression of Cxcr4 1 0.08 1.81 0.19 5.00
74 INT280275 Tgfb1 Positive_regulation of VEGFA 1 0.02 2.46 0.19 5.00
75 INT280268 Tgfb1 Positive_regulation of Gene_expression of Vegfa 1 0.06 1.81 0.19 5.00
76 INT280266 Tgfb1 Positive_regulation of Vegfa 1 0.09 1.8 0.19 5.00
77 INT280261 Tgfb1 Positive_regulation of Gene_expression of Cxcr1 1 0.05 1.81 0.19 5.00
78 INT280267 Tgfb1 Positive_regulation of Cxcr4 1 0.11 2.45 0.19 5.00
79 INT280274 Tgfb1 Positive_regulation of Gene_expression of VEGFA 1 0.02 2.58 0.19 5.00
80 INT293698 Positive_regulation of Binding of Akt1 and Plek 1 0.05 0.12 0.15 5.00
81 INT293695 Binding of Akt1 and Plek 1 0.03 0.12 0.15 5.00
82 INT293699 Regulation of Binding of Akt1 and Plek 1 0.04 0.12 0.15 5.00
83 INT180960 Protein_catabolism of COL5A2 Positive_regulation of Positive_regulation of NPEPPS 1 0.00 0.59 0.14 5.00
84 INT180963 COL5A2 Positive_regulation of Positive_regulation of NPEPPS 1 0.00 0.59 0.14 5.00
85 INT293697 Dock2 Positive_regulation of Akt1 1 0.14 0.08 0.13 5.00
86 INT293696 Mthfd1 Positive_regulation of Akt1 1 0.05 0.08 0.13 5.00
87 INT343542 ROCK1 Positive_regulation of Positive_regulation of PTHLH 1 0.21 0 0.12 5.00
88 INT217470 Traf6 Positive_regulation of Ngf 1 0.36 0.52 0.1 5.00
89 INT217476 Nup62 Positive_regulation of Ngf 1 0.37 0.52 0.1 5.00
90 INT217477 Traf6 Positive_regulation of Binding of Nup62 1 0.32 0.47 0.09 5.00
91 INT311990 FCGR3B Regulation of STAM 1 0.01 0.27 0.09 5.00
92 INT311994 Binding of FCGR3B and Positive_regulation of TNF 1 0.52 0 0.06 5.00
93 INT225262 Egf Regulation of Gene_expression of S100a7a 1 0.04 3.31 0.06 5.00
94 INT217472 Binding of Nup62 and Mul1 1 0.12 0 0.05 5.00
95 INT217471 Binding of Nup62 and Traf6 1 0.26 0 0.05 5.00
96 INT217468 Positive_regulation of Binding of Nup62 and Mul1 1 0.16 0 0.05 5.00
97 INT225261 S100a7a Positive_regulation of Egf 1 0.07 1.13 0.05 5.00
98 INT343538 TGFB1 Positive_regulation of Gene_expression of GLI2 1 0.08 0.2 0.05 5.00
99 INT217467 Binding of Nup62 and Tnfrsf11a 1 0.31 0 0.05 5.00
100 INT269249 Ptk2 Positive_regulation of Phosphorylation of Src 1 0.13 0.93 0.04 5.00
101 INT269250 Ptk2 Positive_regulation of Src 1 0.13 0.86 0.04 5.00
102 INT217474 Tnfrsf11a Regulation of Gene_expression of Tnfsf11 1 0.41 1.2 0.04 5.00
103 INT225259 Egfr Regulation of Gene_expression of S100a7a 1 0.04 0.98 0.04 5.00
104 INT343540 Binding of PPP1R12A and MLC1 1 0.09 0.15 0.04 5.00
105 INT264148 Binding of CLCN7 and Ostm1 1 0.17 0.72 0.03 5.00
106 INT280263 Binding of Smad4 and Proc 1 0.00 1.26 0.03 5.00
107 INT180954 PASK Regulation of COL5A2 1 0.00 0.7 0.03 5.00
108 INT210592 Binding of Cd4 and Vcam1 1 0.01 0.65 0.03 5.00
109 INT311995 FCGR3B Regulation of Gene_expression of TNF 1 0.46 0 0.03 5.00
110 INT343537 ROCK1 Regulation of Gene_expression of PTHLH 1 0.08 0.09 0.03 5.00
111 INT225258 Egf Positive_regulation of Gene_expression of S100a7a 1 0.07 1.7 0 5.00
112 INT311992 Binding of FCGR3B and STAM 1 0.02 0 0 5.00
113 INT310186 Binding of Gdf2 and Bmpr2 1 0.02 0 0 5.00
114 INT217473 Nup62 Regulation of Tnfrsf11a 1 0.38 0.66 0 5.00
115 INT269251 Lox Negative_regulation of Ptk2 Negative_regulation of Lox 1 0.26 1.02 0 5.00
116 INT302321 Negative_regulation of Binding of Lrp6 and SOST 1 0.16 0.26 0 5.00
117 INT302322 Negative_regulation of Binding of Lrp5 and SOST 1 0.16 0.26 0 5.00
118 INT310191 Flt3 Positive_regulation of Gene_expression of Id1 1 0.03 0.81 0 5.00
119 INT280265 Binding of Cxcr4 and Tgfb1 1 0.06 0.89 0 5.00
120 INT269248 Lox Negative_regulation of Ptk2 1 0.24 1.02 0 5.00
121 INT264143 TCIRG1 Regulation of BSND 1 0.02 0.74 0 5.00
122 INT343541 PTHLH Positive_regulation of GYPA 1 0.03 0.95 0 5.00
123 INT310188 Binding of Adcyap1r1 and Smad7 1 0.00 0 0 5.00
124 INT302320 Binding of Lrp6 and SOST 1 0.18 0.26 0 5.00
125 INT225266 Erbb2 Positive_regulation of Gene_expression of VEGFA 1 0.04 0.79 0 5.00
126 INT264144 CLCN7 Regulation of ADO 1 0.04 0.71 0 5.00
127 INT191166 Regulation of DBT Positive_regulation of PGR 1 0.01 0 0 5.00
128 INT217487 Binding of PDB1 and Tnfrsf11a 1 0.03 0.76 0 5.00
129 INT280272 VEGFA Regulation of Cxcr4 1 0.05 0.87 0 5.00
130 INT302323 Binding of SOST and Wnt2 1 0.02 0.26 0 5.00
131 INT225260 S100a7a Positive_regulation of Phosphorylation of Egfr 1 0.07 0.18 0 5.00
132 INT343548 GLI2 Positive_regulation of Gene_expression of PTHLH 1 0.28 0.94 0 5.00
133 INT217480 Tnfsf11 Negative_regulation of Tnfrsf11a 1 0.39 0.75 0 5.00
134 INT302319 Binding of Lrp5 and SOST 1 0.18 0.26 0 5.00
135 INT191169 DBT Positive_regulation of PGR 1 0.02 0 0 5.00
136 INT191170 DBT Positive_regulation of Positive_regulation of PGR 1 0.02 0 0 5.00
137 INT191168 DBT Negative_regulation of ESR1 1 0.02 0 0 5.00
138 INT191165 DBT Positive_regulation of DBT Positive_regulation of PGR 1 0.00 0 0 5.00
139 INT280269 Tgfb1 Regulation of Cxcr4 1 0.04 0.88 0 5.00
140 INT225263 S100a7a Regulation of Phosphorylation of Egf 1 0.04 0.84 0 5.00
141 INT188435 PDB1 Negative_regulation of Binding of SQSTM1 1 0.41 0.49 0 5.00
142 INT343549 GLI2 Positive_regulation of GYPA 1 0.05 0.95 0 5.00
143 INT220455 BAG6 Regulation of INCENP 1 0.00 0.32 0 5.00
144 INT310187 Acvrl1 Regulation of Gene_expression of Bmpr2 1 0.04 0 0 5.00
145 INT293694 Binding of Ccl21a and Mthfd1 1 0.01 0 0 5.00
146 INT280264 Negative_regulation of Binding of Cxcr4 and Tgfb1 1 0.07 0.89 0 5.00
147 INT310189 Binding of Acvrl1 and Gdf2 1 0.01 0 0 5.00
148 INT280273 Tgfb1 Regulation of VEGFA 1 0.01 0.88 0 5.00
149 INT191172 DBT Positive_regulation of Regulation of ESR1 1 0.02 0 0 5.00
150 INT310190 Binding of Adcyap1r1 and Smad6 1 0.00 0 0 5.00
151 INT310192 Tgfbr1 Positive_regulation of Regulation of Acvrl1 1 0.01 0 0 5.00
152 INT191167 DBT Positive_regulation of Localization of ESR1 1 0.03 0 0 5.00
153 INT220461 Binding of VCAN and EGFR 1 0.00 0.86 0 5.00
154 INT191173 Regulation of DBT Negative_regulation of ESR1 1 0.01 0 0 5.00
155 INT293410 HRAS Regulation of Localization of SPP1 1 0.00 0.8 0 5.00
156 INT343539 GLI2 Regulation of PTHLH 1 0.15 0.25 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Osteolysis. They are ordered first by their pain relevance and then by number of times they were reported in Osteolysis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 100.00
2 INT184206 Protein_catabolism of HRAS 22 0.66 7.86 1.46 100.00
3 INT120072 Gene_expression of Smad7 38 0.74 20.87 3.69 100.00
4 INT55962 Positive_regulation of Localization of PROC 9 0.20 7.76 1.87 100.00
5 INT95670 Regulation of PDB1 4 0.60 5.59 0.55 99.96
6 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 99.92
7 INT4535 Localization of PROC 106 0.73 76.24 21.1 99.90
8 INT17701 Gene_expression of PTHLH 103 0.78 64.23 8.85 99.80
9 INT62072 Negative_regulation of Gene_expression of PTHLH 3 0.43 4.45 0.85 99.80
10 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18 99.72
11 INT130867 Gene_expression of TNFSF11 106 0.77 45.15 10.34 99.66
12 INT93534 Gene_expression of Tnfsf11 185 0.77 119.26 33.66 99.48
13 INT135181 Regulation of Gene_expression of TNFSF11 5 0.61 6.98 1.27 99.46
14 INT72138 Gene_expression of Pthlh 18 0.75 17.68 1.49 99.44
15 INT109005 Gene_expression of Proc 61 0.75 37.86 8.49 99.44
16 INT179826 Gene_expression of Il11 29 0.75 11.5 3.75 99.44
17 INT95669 Regulation of TNFRSF11A 7 0.56 10.01 0.94 99.40
18 INT2542 Localization of Calca 2008 0.81 518.3 1408.65 99.40
19 INT764 Gene_expression of OLAH 25 0.67 25.58 8.07 99.36
20 INT225251 Negative_regulation of S100a7a 1 0.12 8.91 0.43 99.36
21 INT105199 Regulation of REG3A 1 0.60 0.75 0.06 99.36
22 INT107605 Gene_expression of MMP14 26 0.64 25.88 4.49 99.28
23 INT144073 Positive_regulation of Gene_expression of MMP14 4 0.24 6.13 0.72 99.28
24 INT105920 Binding of SLC9A3R2 5 0.36 1.99 1.75 99.26
25 INT180975 Gene_expression of IL19 20 0.75 9.12 1.13 99.04
26 INT225255 Negative_regulation of Gene_expression of S100a7a 1 0.08 2.28 0.03 99.04
27 INT355352 Gene_expression of NOG 1 0.36 24.11 1.23 98.96
28 INT104207 Positive_regulation of Gene_expression of Tnfsf11 43 0.69 25.8 7.35 98.88
29 INT256860 Negative_regulation of Negative_regulation of Mtpn 2 0.16 1.31 0.5 98.88
30 INT6852 Localization of TNF 883 0.81 705.95 270.84 98.76
31 INT86516 Positive_regulation of Hmox2 6 0.69 3.22 4.39 98.72
32 INT84561 Binding of COL1A2 18 0.47 11.76 5.09 98.66
33 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 98.60
34 INT93533 Positive_regulation of Tnfsf11 53 0.50 36.93 10.53 98.56
35 INT105598 Negative_regulation of Mtpn 15 0.16 11.83 2.65 98.52
36 INT104839 Negative_regulation of GLI2 8 0.35 2.7 1.24 98.44
37 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 98.40
38 INT220465 Binding of BAG6 7 0.30 6.41 1.07 98.40
39 INT220469 Binding of VCAN 1 0.06 6.24 0.13 98.40
40 INT14731 Positive_regulation of TGFB1 78 0.67 52.57 22.23 98.36
41 INT258250 Positive_regulation of ROCK1 7 0.51 2.07 0.22 98.36
42 INT84367 Gene_expression of S100a7a 2 0.15 25.36 1.16 98.32
43 INT109133 Gene_expression of VCAN 52 0.75 53.11 0.84 98.24
44 INT158979 Negative_regulation of Localization of TNFRSF11B 2 0.57 3.08 0.1 98.12
45 INT355358 Positive_regulation of Gene_expression of NOG 1 0.20 5.75 0.07 97.88
46 INT136555 Negative_regulation of Tnfsf11 31 0.55 22.23 6.23 97.88
47 INT355346 Negative_regulation of Gene_expression of NOG 1 0.20 5.87 0.33 97.88
48 INT123458 Positive_regulation of Tnfrsf11b 9 0.43 14.3 2.01 97.88
49 INT158978 Localization of TNFRSF11B 19 0.78 11.8 3.32 97.82
50 INT103244 Protein_catabolism of MMP9 12 0.72 11.81 2.01 97.72
51 INT2867 Gene_expression of CALCA 247 0.78 78.78 138.47 97.68
52 INT23463 Positive_regulation of Gene_expression of CALCA 47 0.70 18.14 28.76 97.68
53 INT27268 Localization of Gtf3a 71 0.21 56.93 12.51 97.64
54 INT626 Localization of CALCA 289 0.81 125.39 221.15 97.64
55 INT134889 Negative_regulation of TNFRSF11A 9 0.42 12.65 1.76 97.60
56 INT162057 Negative_regulation of TNFSF11 14 0.58 9.78 1.46 97.60
57 INT113282 Negative_regulation of TNFRSF11B 17 0.57 13.71 4.17 97.60
58 INT210605 Negative_regulation of Negative_regulation of TNFSF11 2 0.42 1.65 0.1 97.60
59 INT210606 Negative_regulation of Negative_regulation of TNFRSF11B 2 0.19 2.7 0.03 97.60
60 INT210604 Negative_regulation of Negative_regulation of TNFRSF11A 1 0.32 1.59 0.03 97.60
61 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 97.48
62 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 97.44
63 INT73047 Positive_regulation of MMP9 133 0.68 73.22 26.42 97.44
64 INT105344 Gene_expression of Cited2 5 0.78 3.65 0.76 97.32
65 INT105340 Negative_regulation of Gene_expression of Cited2 1 0.59 1.6 0.36 97.32
66 INT12081 Localization of TGFB1 64 0.81 35.4 17.47 97.28
67 INT141611 Positive_regulation of Gene_expression of Ccr1 25 0.69 20.32 6.42 97.24
68 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 97.16
69 INT220472 Gene_expression of BAG6 1 0.11 13.93 0.12 97.12
70 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34 97.08
71 INT69681 Negative_regulation of Tgfb1 42 0.51 22.28 4 96.96
72 INT135759 Positive_regulation of Setmar 1 0.05 0.48 0.3 96.96
73 INT24326 Gene_expression of Ngf 346 0.78 218.67 184.71 96.88
74 INT141612 Gene_expression of Ccr1 92 0.77 72.09 24.14 96.72
75 INT19763 Gene_expression of CTs 69 0.78 32.92 18.87 96.68
76 INT127480 Negative_regulation of Hsp90aa1 20 0.57 10.67 0.56 96.68
77 INT105339 Positive_regulation of Gene_expression of Cited2 2 0.70 1.59 0.41 96.52
78 INT61817 Gene_expression of Rhoc 1 0.18 1.49 0.08 96.40
79 INT180885 Positive_regulation of Gene_expression of VCAN 10 0.35 12.52 0.18 96.36
80 INT285 Positive_regulation of Salpa1 73 0.68 61.47 9.19 96.20
81 INT2836 Positive_regulation of PAEP 51 0.67 26.69 4.57 96.16
82 INT14740 Gene_expression of TGFB1 272 0.78 168.48 60.18 96.04
83 INT144490 Regulation of Gene_expression of Tnfsf11 14 0.58 14.09 2.39 96.04
84 INT107607 Negative_regulation of MMP14 10 0.37 6.05 1.83 95.64
85 INT5398 Positive_regulation of ALPP 178 0.70 110.52 19.18 95.52
86 INT6516 Positive_regulation of BGLAP 45 0.67 26.61 9.9 95.52
87 INT126534 Negative_regulation of ROCK1 18 0.49 14.32 1.13 95.40
88 INT19963 Gene_expression of COL1A1 118 0.59 42.11 15.15 95.28
89 INT113717 Negative_regulation of Gene_expression of COL1A1 21 0.41 6.14 2.01 95.28
90 INT102233 Gene_expression of MMP7 40 0.76 15.78 2.93 95.28
91 INT210609 Positive_regulation of Localization of TNFSF11 1 0.41 1.12 0.04 95.20
92 INT65537 Positive_regulation of Positive_regulation of Nfkb1 52 0.67 30.6 26.35 95.08
93 INT93532 Regulation of Tnfsf11 14 0.42 10.75 2.39 94.92
94 INT13354 Transcription of TNF 108 0.72 85.81 42.32 94.84
95 INT205171 Localization of TNFSF11 4 0.74 3.94 0.66 94.80
96 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 94.76
97 INT65054 Positive_regulation of Nfkb1 285 0.70 149.33 126.73 94.68
98 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 94.60
99 INT49238 Protein_catabolism of COL1A2 30 0.97 15.64 3.45 94.48
100 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 94.48
101 INT171017 Localization of IL11 9 0.64 4.83 0.76 94.40
102 INT293421 Regulation of Localization of IL11 1 0.08 0.6 0 94.40
103 INT111156 Negative_regulation of Dkk1 21 0.58 20.08 4.27 94.16
104 INT279809 Localization of ERBB3 3 0.01 2.08 0 94.16
105 INT312015 Phosphorylation of FCGR3B 1 0.78 0.66 0.29 94.08
106 INT17024 Gene_expression of COL1A2 69 0.77 36.38 8.29 94.00
107 INT108306 Positive_regulation of TNFRSF11B 28 0.60 12.74 4.46 93.92
108 INT10094 Negative_regulation of ALPP 36 0.37 20.45 6.45 93.92
109 INT84310 Regulation of Gene_expression of Tgfb1 7 0.29 6.6 1.63 93.68
110 INT134646 Gene_expression of Tnfsf11 19 0.69 14.77 4.16 93.56
111 INT171962 Gene_expression of Tnfrsf11a 40 0.72 31.1 7.84 93.56
112 INT17250 Negative_regulation of BGLAP 35 0.57 21 8.26 93.56
113 INT188448 Negative_regulation of SQSTM1 4 0.53 3.75 0.55 93.52
114 INT150237 Localization of Ccr1 10 0.75 9.25 4.72 93.40
115 INT48202 Gene_expression of Tgfb1 146 0.78 89.93 27.76 93.28
116 INT73670 Gene_expression of Vcam1 128 0.78 123.79 24.96 93.20
117 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68 93.00
118 INT27798 Gene_expression of Ntrk2 111 0.78 56.08 42.68 93.00
119 INT17818 Gene_expression of Agtr2 24 0.56 12.96 4.41 93.00
120 INT188443 Negative_regulation of NUP62 1 0.33 1.53 0 92.96
121 INT743 Negative_regulation of Salpa1 16 0.57 8.75 3.1 92.44
122 INT62071 Positive_regulation of Gene_expression of PTHLH 13 0.70 19.32 1.73 92.40
123 INT171959 Binding of Tnfrsf11a 15 0.34 11.03 3.02 92.28
124 INT119729 Binding of Tnfsf11 31 0.35 24.02 7.45 92.08
125 INT217438 Binding of Chuk 24 0.25 7.29 1.29 92.08
126 INT124774 Binding of Vcp 4 0.44 3.4 0.52 92.08
127 INT118264 Binding of Hmbs 6 0.37 4.87 0.33 92.08
128 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 91.76
129 INT61818 Positive_regulation of Ocln 6 0.23 4.11 0.22 91.20
130 INT28216 Gene_expression of HRAS 173 0.75 93.97 20.78 91.04
131 INT80175 Positive_regulation of Gene_expression of HRAS 24 0.67 14.69 3.97 91.04
132 INT37363 Localization of PTHLH 14 0.68 13.23 2.92 90.88
133 INT61819 Positive_regulation of Ostf1 1 0.00 1.25 0.09 90.80
134 INT123459 Gene_expression of Tnfrsf11b 35 0.58 24.16 7.26 90.64
135 INT93017 Binding of PDB1 8 0.36 6.36 0.51 89.88
136 INT37530 Regulation of Salpa1 8 0.59 4.79 1.19 89.68
137 INT160538 Binding of Bmp2 4 0.40 2.08 1.07 89.68
138 INT178763 Binding of HHIP 37 0.08 6.3 5.29 89.56
139 INT71305 Regulation of Gene_expression of NFKB1 9 0.61 5.41 2.44 89.00
140 INT1683 Gene_expression of Cux1 20 0.58 6.29 3.59 88.96
141 INT81989 Positive_regulation of Tnfsf11 11 0.54 7.57 2.4 88.56
142 INT10834 Binding of IL8 65 0.48 41.66 16.53 88.48
143 INT355353 Binding of NOG 1 0.17 2.33 0.38 88.36
144 INT355345 Localization of NOG 1 0.37 16.14 0.71 88.24
145 INT66606 Gene_expression of CXCR1 34 0.75 27.79 11.36 87.92
146 INT48888 Localization of Pbrgcsf1 11 0.29 5.04 2.05 87.68
147 INT300893 Protein_catabolism of HSPG2 1 0.27 1.1 0.41 87.44
148 INT152729 Negative_regulation of Gene_expression of S100a8 33 0.42 32.25 13.64 87.44
149 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 87.36
150 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 87.20
151 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 87.04
152 INT82448 Gene_expression of S100a8 246 0.77 236.72 84.02 87.00
153 INT24458 Negative_regulation of PDB1 8 0.41 4.5 1.5 86.88
154 INT155775 Gene_expression of PDB1 12 0.65 10.18 0.41 86.88
155 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 86.80
156 INT25610 Positive_regulation of Gene_expression of Il1 136 0.67 104.43 43.86 86.80
157 INT242131 Localization of Dkk1 5 0.79 6 0.76 86.68
158 INT172555 Positive_regulation of Localization of Proc 1 0.00 1.82 0 86.68
159 INT138125 Positive_regulation of MMP14 5 0.49 4.04 0.52 86.68
160 INT210608 Negative_regulation of Binding of TNFSF11 2 0.25 2.31 0.04 86.64
161 INT129883 Gene_expression of Dkk1 56 0.77 45.42 12.52 86.36
162 INT93016 Binding of TNFRSF11A 29 0.47 19.67 4.17 86.12
163 INT172559 Localization of Proc 16 0.02 21.49 2.08 86.08
164 INT182643 Binding of TNFSF11 15 0.35 13.12 1.61 85.92
165 INT245721 Localization of FRZB 6 0.78 4.3 0.6 85.88
166 INT12339 Localization of IL8 437 0.81 251.87 117.39 85.84
167 INT48222 Positive_regulation of Localization of IL8 123 0.59 78.04 37.2 85.84
168 INT4991 Positive_regulation of Vim 74 0.69 69.84 8.33 85.76
169 INT1221 Regulation of SGCG 65 0.60 24.21 22.94 85.76
170 INT202693 Gene_expression of LCS1 3 0.32 0.99 0 85.60
171 INT130866 Positive_regulation of Gene_expression of TNFSF11 25 0.69 7.11 1.82 85.52
172 INT20981 Binding of HRAS 42 0.48 24.49 4.23 84.80
173 INT96034 Negative_regulation of Proc 11 0.33 10.21 1.18 84.76
174 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 84.76
175 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 84.76
176 INT199550 Negative_regulation of Flt1 18 0.37 12.57 1.37 84.76
177 INT264991 Positive_regulation of Localization of Tnfsf11 5 0.24 3.22 0.59 84.64
178 INT93735 Gene_expression of P4hb 6 0.49 4.63 1.39 84.56
179 INT111153 Positive_regulation of Dkk1 13 0.68 10.56 2.58 84.20
180 INT88544 Gene_expression of MMRN1 102 0.75 68.8 14.55 84.08
181 INT48198 Binding of Tgfb1 29 0.47 19.59 2.46 83.96
182 INT50814 Positive_regulation of Mmp2 72 0.68 51.37 20.42 83.92
183 INT295000 Binding of Tnfsf11 5 0.32 2.27 0.32 83.92
184 INT194342 Gene_expression of Csf1r 5 0.59 4.05 1.51 83.88
185 INT196141 Gene_expression of Ostf1 2 0.09 2.85 0.08 83.88
186 INT355349 Regulation of NOG 1 0.21 4.23 0.09 83.88
187 INT63769 Regulation of Ngf 44 0.62 21.82 25.84 83.84
188 INT128634 Gene_expression of OSTF1 2 0.40 0.67 0.22 83.84
189 INT55170 Gene_expression of NFKB1 97 0.77 52.75 23.04 83.76
190 INT164205 Binding of Proc 12 0.36 12.31 1.19 83.68
191 INT12720 Positive_regulation of Il1 246 0.70 195.97 72.05 83.36
192 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 83.16
193 INT134624 Gene_expression of Flt1 77 0.66 48.86 7.27 83.16
194 INT213533 Positive_regulation of Gene_expression of Proc 6 0.01 5.55 0.49 83.12
195 INT6481 Binding of TNF 624 0.48 510.2 214.82 82.64
196 INT128635 Gene_expression of OAF 3 0.70 0.86 0.58 82.64
197 INT3823 Positive_regulation of ALPI 27 0.69 19.49 2.15 82.48
198 INT166707 Protein_catabolism of Col7a1 24 0.74 20.47 6.39 82.32
199 INT9657 Positive_regulation of Gene_expression of Il6 237 0.70 180.45 63.6 81.84
200 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 81.84
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