D:Osteopetrosis

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Disease Term
Synonyms ALBERS SCHOENBERG DISEASE, CONGENITAL OSTEOPETROSIS, Congenital Osteosclerosis, Disease Albers Schoenberg, Disease Marble Bone, Ivory Bones, MARBLE BONE, Marble Bone Disease, Osteopetroses, Osteopetrosis Congenita Type, Osteopetrosis Disorder
Documents 54
Hot Single Events 44
Hot Interactions 9

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Osteopetrosis. They are ordered first by their relevance to Osteopetrosis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT264144 CLCN7 Regulation of ADO 1 0.04 0.71 0 100.00
2 INT264143 TCIRG1 Regulation of BSND 1 0.02 0.74 0 99.96
3 INT264148 Binding of CLCN7 and Ostm1 1 0.17 0.72 0.03 99.72
4 INT254433 Binding of Lrp5 and Sost 2 0.39 1.51 0.03 97.72
5 INT254432 Binding of Best1 and Sost 1 0.12 0.69 0 97.72
6 INT181998 TNFRSF11B Negative_regulation of Gene_expression of CTSK 1 0.07 1.98 0.27 94.56
7 INT209444 Stam Positive_regulation of Syk 1 0.01 0.26 0 87.92
8 INT182636 Binding of TNFSF11 and TNFRSF11A 16 0.29 17.5 0.84 84.88
9 INT123462 Binding of TNF and Tnfrsf11b 3 0.21 3.52 0.24 80.32
10 INT171974 Binding of Tnfrsf11a and Tnfsf11 14 0.35 13.11 3.11 76.08
11 INT172125 Binding of Tnfrsf11b and Tnfrsf11a 2 0.17 2.12 0.39 76.08
12 INT182644 Binding of CXCR4 and Cxcr4 1 0.10 0.66 0.09 63.48
13 INT182635 Binding of CCR5 and CCL5 2 0.09 4.19 3 55.40
14 INT182634 Binding of CCR5 and MIP 2 0.39 1.29 0.2 55.40
15 INT254434 Binding of Lrp5 and Best1 3 0.29 2.53 0 40.56
16 INT301292 Negative_regulation of Clec5a Negative_regulation of TNF 1 0.05 1.04 0.27 20.16
17 INT207391 Il17a Positive_regulation of Gene_expression of Tnfsf11 2 0.05 1.19 0.77 5.00
18 INT170832 Cftr Regulation of Scnn1a 2 0.16 1.2 0.67 5.00
19 INT207396 IL6 Positive_regulation of Gene_expression of Tnfsf11 1 0.03 0.95 0.51 5.00
20 INT207394 IL1B Positive_regulation of Gene_expression of Tnfsf11 1 0.05 0.95 0.51 5.00
21 INT301285 Binding of Tyrobp and Clec5a 1 0.32 1.63 0.49 5.00
22 INT207395 TNF Regulation of Gene_expression of Tnfsf11 1 0.11 0.91 0.49 5.00
23 INT301277 Il6 Positive_regulation of Positive_regulation of Clec5a 1 0.16 0.37 0.29 5.00
24 INT301287 Positive_regulation of Clec5a Positive_regulation of Gene_expression of Il6 1 0.14 0.58 0.29 5.00
25 INT301289 Positive_regulation of Clec5a Positive_regulation of Gene_expression of Atp6v0d2 1 0.02 1.01 0.28 5.00
26 INT301276 Il6 Positive_regulation of Gene_expression of Tnfrsf11a 1 0.06 0.37 0.26 5.00
27 INT301280 Il6 Positive_regulation of Gene_expression of Acp5 1 0.04 0.37 0.26 5.00
28 INT301291 Il6 Positive_regulation of Gene_expression of TNF 1 0.01 0.37 0.26 5.00
29 INT301279 Tnfsf11 Regulation of Gene_expression of Mmp9 1 0.13 0.34 0.21 5.00
30 INT301281 Tnfsf11 Regulation of Gene_expression of Clec5a 1 0.22 0.34 0.21 5.00
31 INT301290 Tnfsf11 Positive_regulation of Nfatc1 1 0.15 0.65 0.2 5.00
32 INT301282 Tnfsf11 Positive_regulation of Traf6 1 0.10 0.65 0.2 5.00
33 INT181996 TNFRSF11B Positive_regulation of Gene_expression of TIMP1 1 0.00 0.67 0.18 5.00
34 INT301278 Nfatc1 Regulation of Acp5 1 0.05 0.19 0.15 5.00
35 INT181997 TNFRSF11B Negative_regulation of CTSK 1 0.05 0.58 0.14 5.00
36 INT334541 Binding of HIVEP1 and TNF 1 0.01 1.32 0.13 5.00
37 INT301283 Nfatc1 Regulation of Ctsk 1 0.06 0.19 0.13 5.00
38 INT301284 Tnfsf11 Positive_regulation of Localization of Nfatc1 1 0.16 0.32 0.11 5.00
39 INT301288 Clec5a Regulation of Nfatc1 1 0.21 0.25 0.1 5.00
40 INT289836 BEST1 Positive_regulation of Gene_expression of Car2 1 0.03 0.08 0 5.00
41 INT254435 Binding of Esr1 and Best1 1 0.21 0.06 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Osteopetrosis. They are ordered first by their pain relevance and then by number of times they were reported in Osteopetrosis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT71047 Gene_expression of CYP19A1 122 0.78 68.78 22.21 100.00
2 INT264146 Gene_expression of MYO7A 1 0.05 1.36 0 100.00
3 INT90090 Gene_expression of ADO 4 0.58 1.41 0.42 100.00
4 INT264145 Gene_expression of BSND 1 0.04 1.25 0 100.00
5 INT152222 Positive_regulation of Csf1 1 0.02 0.99 0.17 100.00
6 INT173578 Negative_regulation of CTSK 8 0.44 6.29 1.15 99.92
7 INT23533 Gene_expression of CA2 110 0.75 30.81 19.4 99.84
8 INT259408 Gene_expression of Atp6v0d2 5 0.09 2.01 0.54 99.28
9 INT216848 Gene_expression of TCIRG1 8 0.52 2.59 1.95 99.28
10 INT264147 Gene_expression of CLCN7 1 0.35 0.73 0 99.28
11 INT46619 Gene_expression of CSF1 80 0.73 36.63 12.94 98.92
12 INT209436 Transcription of Tyrobp 1 0.61 0.26 0 97.68
13 INT289814 Negative_regulation of Clcn3 1 0.05 2.54 0.14 97.40
14 INT209443 Negative_regulation of Tyrobp 8 0.45 1.45 0.55 97.04
15 INT209425 Negative_regulation of Negative_regulation of Tyrobp 1 0.33 0.29 0 97.04
16 INT207382 Regulation of Pgia1 2 0.08 4.96 1.57 96.48
17 INT224838 Positive_regulation of Transcription of Csf2 4 0.42 1.49 0.15 96.16
18 INT9695 Negative_regulation of Csf2 41 0.57 31.65 6.28 96.12
19 INT75932 Binding of Csf2 45 0.37 33.2 8.01 96.12
20 INT49250 Regulation of Atp6v0d2 5 0.08 1.54 2.04 96.04
21 INT181396 Transcription of Csf2 15 0.48 6.38 2.17 94.48
22 INT130865 Positive_regulation of TNFSF11 29 0.69 12.82 2.99 94.44
23 INT17283 Positive_regulation of CSF1 37 0.59 24.16 10.01 94.44
24 INT91527 Gene_expression of CTSK 38 0.78 22.21 7.42 92.72
25 INT209424 Binding of Tyrobp 5 0.43 2.03 0.33 92.40
26 INT254429 Negative_regulation of Lrp5 4 0.57 1.95 0.18 92.40
27 INT9694 Positive_regulation of Csf2 102 0.68 70.09 33.07 91.44
28 INT97152 Protein_catabolism of COL1A1 11 0.74 8.03 2.3 89.44
29 INT209427 Positive_regulation of Phosphorylation of Stam 1 0.05 0.26 0 89.44
30 INT209438 Phosphorylation of Stam 2 0.09 0.45 0 88.92
31 INT134889 Negative_regulation of TNFRSF11A 9 0.42 12.65 1.76 88.16
32 INT136555 Negative_regulation of Tnfsf11 31 0.55 22.23 6.23 87.52
33 INT209429 Gene_expression of Stam 2 0.08 0.32 0 86.00
34 INT93016 Binding of TNFRSF11A 29 0.47 19.67 4.17 84.88
35 INT16166 Positive_regulation of DMD 348 0.67 133.22 15.06 83.92
36 INT182643 Binding of TNFSF11 15 0.35 13.12 1.61 83.12
37 INT289825 Positive_regulation of Aqp6 2 0.21 0.62 0.07 81.60
38 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 81.56
39 INT206525 Regulation of Trem2 4 0.62 4.65 1.26 81.04
40 INT209435 Regulation of Tyrobp 2 0.40 1.55 0.37 81.04
41 INT182637 Positive_regulation of Binding of ERVW-1 1 0.12 0.53 0.04 80.84
42 INT79357 Binding of ERVW-1 32 0.43 16.06 1.35 80.32
43 INT36287 Binding of CD4 96 0.47 58.93 11.88 80.32
44 INT207383 Positive_regulation of Pgia1 4 0.09 6.39 2.14 80.08
45 INT171959 Binding of Tnfrsf11a 15 0.34 11.03 3.02 79.76
46 INT119729 Binding of Tnfsf11 31 0.35 24.02 7.45 78.96
47 INT135419 Binding of Tnfrsf11b 5 0.34 4.15 0.53 78.96
48 INT316570 Binding of BMP7 3 0.37 0.95 0.07 76.92
49 INT114664 Binding of BMP2 12 0.37 6.54 0.91 76.92
50 INT130867 Gene_expression of TNFSF11 106 0.77 45.15 10.34 76.56
51 INT28312 Gene_expression of ABCA1 85 0.72 37.69 9.27 76.56
52 INT9693 Localization of Entpd4 1 0.19 0.21 0.14 75.00
53 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 74.64
54 INT174552 Gene_expression of Tyrobp 6 0.60 2.29 0.42 73.44
55 INT132846 Localization of Tnfsf11 17 0.69 10.28 2.78 72.88
56 INT207379 Regulation of Negative_regulation of Tnfsf11 2 0.28 1.7 0.5 72.64
57 INT93534 Gene_expression of Tnfsf11 185 0.77 119.26 33.66 72.56
58 INT215807 Gene_expression of Clcn3 5 0.19 3.2 0.48 71.12
59 INT289822 Regulation of Gene_expression of Clcn3 1 0.05 0.91 0.04 71.12
60 INT207378 Negative_regulation of Pgia1 2 0.08 1.91 0.74 70.92
61 INT211971 Binding of Best1 16 0.22 7.73 0.33 65.52
62 INT179788 Gene_expression of Sparc 42 0.77 19.96 2.57 64.32
63 INT182629 Binding of Cxcr4 12 0.36 5.24 1.47 63.48
64 INT11659 Gene_expression of COL2A1 164 0.78 78.49 22.58 63.04
65 INT19963 Gene_expression of COL1A1 118 0.59 42.11 15.15 61.60
66 INT171962 Gene_expression of Tnfrsf11a 40 0.72 31.1 7.84 60.48
67 INT89292 Positive_regulation of CCR5 27 0.70 15.12 8.59 60.44
68 INT209433 Negative_regulation of Binding of Tyrobp 1 0.33 0.17 0.04 48.56
69 INT301263 Gene_expression of Clec5a 22 0.77 14.64 5.18 46.20
70 INT207384 Gene_expression of Pgia1 3 0.14 18.55 6.87 44.40
71 INT96271 Positive_regulation of Gene_expression of Mcpt1 30 0.53 21.34 11.06 43.16
72 INT72182 Gene_expression of Mcpt1 167 0.75 123.7 52.15 42.80
73 INT95668 Positive_regulation of Tnfrsf11a 12 0.47 10.14 1.34 40.96
74 INT182642 Localization of LTBR 2 0.03 0.64 0.03 32.96
75 INT108306 Positive_regulation of TNFRSF11B 28 0.60 12.74 4.46 30.96
76 INT159988 Localization of Ctsk 5 0.70 2.9 0.74 30.84
77 INT6852 Localization of TNF 883 0.81 705.95 270.84 30.80
78 INT158978 Localization of TNFRSF11B 19 0.78 11.8 3.32 27.28
79 INT254426 Gene_expression of Lrp5 5 0.67 3.28 0.06 26.80
80 INT301261 Negative_regulation of Clec5a 3 0.58 1.68 0.66 20.16
81 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 18.76
82 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 18.64
83 INT171964 Positive_regulation of Gene_expression of Tnfrsf11a 5 0.37 4.11 1.73 18.44
84 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 17.52
85 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 17.52
86 INT121752 Gene_expression of IL11 54 0.62 18.05 7.16 17.52
87 INT254427 Binding of Lrp5 10 0.48 5.43 0.26 16.64
88 INT11937 Localization of Il6 228 0.81 139.83 64.39 16.52
89 INT289830 Negative_regulation of Clcn2 1 0.39 0.23 0 16.40
90 INT15172 Positive_regulation of Itgam 45 0.67 23.54 10.3 15.76
91 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 13.92
92 INT69289 Negative_regulation of Cftr 44 0.57 13.28 6.97 11.92
93 INT160563 Localization of Il17a 34 0.74 26.53 10.24 10.56
94 INT289834 Positive_regulation of Protein_catabolism of LRP2 1 0.45 0.65 0.03 8.64
95 INT104207 Positive_regulation of Gene_expression of Tnfsf11 43 0.69 25.8 7.35 8.00
96 INT25381 Localization of Csf2 62 0.76 47.48 9.03 7.12
97 INT98016 Protein_catabolism of Pth 2 0.18 2.07 0.18 5.28
98 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
99 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
100 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
101 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
102 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
103 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 5.00
104 INT55879 Gene_expression of CCL2 421 0.78 240.74 166.02 5.00
105 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
106 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
107 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 5.00
108 INT118381 Gene_expression of Il17a 405 0.76 306.97 112.06 5.00
109 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 5.00
110 INT7944 Positive_regulation of Fos 193 0.70 60.69 98.31 5.00
111 INT3537 Positive_regulation of Car2 413 0.56 103.51 94.35 5.00
112 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 5.00
113 INT96917 Positive_regulation of Mapk14 261 0.70 173.29 88.79 5.00
114 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 5.00
115 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34 5.00
116 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 5.00
117 INT1759 Gene_expression of TIMP1 267 0.77 133.87 59.29 5.00
118 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 5.00
119 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 5.00
120 INT96937 Gene_expression of Mmp9 191 0.75 150.3 56.01 5.00
121 INT55671 Gene_expression of Ik 151 0.27 80.1 48.49 5.00
122 INT30170 Gene_expression of Car2 330 0.66 77.26 46.76 5.00
123 INT145266 Gene_expression of IL17A 154 0.75 109.83 45.33 5.00
124 INT81498 Positive_regulation of Gene_expression of CCL2 107 0.70 53.89 45.22 5.00
125 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 5.00
126 INT17561 Localization of Car2 303 0.79 60.95 44.52 5.00
127 INT25383 Gene_expression of Csf2 222 0.76 152.93 43.32 5.00
128 INT6105 Positive_regulation of IL2 133 0.69 82.76 34.67 5.00
129 INT15174 Gene_expression of Itgam 238 0.73 104.92 29.26 5.00
130 INT37296 Binding of Esr1 117 0.43 62.51 27.33 5.00
131 INT16428 Positive_regulation of Gtf3a 135 0.20 106.44 26.67 5.00
132 INT100861 Binding of CRP 179 0.48 175.2 26.45 5.00
133 INT10836 Negative_regulation of IL8 95 0.59 52.59 24.71 5.00
134 INT91891 Gene_expression of Kit 268 0.78 158.89 22.67 5.00
135 INT23257 Regulation of CRP 127 0.62 100.05 21.87 5.00
136 INT116282 Gene_expression of Mmp13 83 0.75 45.4 20.18 5.00
137 INT12265 Positive_regulation of IgG 168 0.63 104.89 19.76 5.00
138 INT16167 Negative_regulation of DMD 186 0.57 108.71 15.25 5.00
139 INT1284 Negative_regulation of Mmp13 20 0.57 36.21 14.91 5.00
140 INT25076 Negative_regulation of Gene_expression of Il1 41 0.52 30.58 13.85 5.00
141 INT91360 Negative_regulation of Slc12a2 16 0.54 10.46 12.89 5.00
142 INT110025 Positive_regulation of Positive_regulation of Mapk14 39 0.63 20.67 12.71 5.00
143 INT125477 Gene_expression of HHIP 91 0.78 31.18 12.57 5.00
144 INT96850 Negative_regulation of CCL2 42 0.59 24.89 12.55 5.00
145 INT27268 Localization of Gtf3a 71 0.21 56.93 12.51 5.00
146 INT158124 Gene_expression of COL5A2 136 0.69 72.3 12.44 5.00
147 INT117113 Regulation of Mapk14 28 0.45 16.71 11.99 5.00
148 INT150851 Positive_regulation of Cxcl1 45 0.57 20.83 11.88 5.00
149 INT119400 Phosphorylation of Car2 19 0.52 8.47 11.63 5.00
150 INT25170 Positive_regulation of Localization of Car2 78 0.67 15.25 11.24 5.00
151 INT6515 Gene_expression of BGLAP 110 0.75 45.13 10.81 5.00
152 INT93533 Positive_regulation of Tnfsf11 53 0.50 36.93 10.53 5.00
153 INT180163 Positive_regulation of Nfasc 49 0.40 31.96 9.41 5.00
154 INT17250 Negative_regulation of BGLAP 35 0.57 21 8.26 5.00
155 INT26462 Gene_expression of DNAH8 44 0.78 19.36 7.31 5.00
156 INT153794 Gene_expression of Ctsk 51 0.77 24.99 7.28 5.00
157 INT123459 Gene_expression of Tnfrsf11b 35 0.58 24.16 7.26 5.00
158 INT60700 Gene_expression of Itgax 93 0.71 51.89 6.57 5.00
159 INT66925 Positive_regulation of Gene_expression of Ik 22 0.15 10.47 6.4 5.00
160 INT166707 Protein_catabolism of Col7a1 24 0.74 20.47 6.39 5.00
161 INT6512 Gene_expression of PTH 103 0.77 76.29 6.33 5.00
162 INT13396 Gene_expression of DMD 125 0.75 57.81 5.45 5.00
163 INT178763 Binding of HHIP 37 0.08 6.3 5.29 5.00
164 INT78515 Negative_regulation of Mag 10 0.54 9.4 5.06 5.00
165 INT61252 Negative_regulation of Gene_expression of Itgam 38 0.54 16.48 5.01 5.00
166 INT130300 Gene_expression of Abcc3 14 0.70 5.34 4.96 5.00
167 INT134657 Localization of Akt1 37 0.68 11.58 4.62 5.00
168 INT47766 Transcription of Fos 25 0.69 8.78 4.42 5.00
169 INT19965 Positive_regulation of COL1A1 23 0.45 14.49 4.38 5.00
170 INT67182 Gene_expression of Tms 10 0.53 5.14 4.29 5.00
171 INT160915 Regulation of Mmp9 16 0.35 10.25 4.07 5.00
172 INT32933 Gene_expression of GNAS 57 0.32 10.58 4.03 5.00
173 INT194913 Localization of Nfasc 17 0.36 9.91 3.76 5.00
174 INT111532 Gene_expression of Nfatc1 15 0.75 5.27 3.73 5.00
175 INT174277 Positive_regulation of Positive_regulation of Gopc 23 0.33 8.08 3.73 5.00
176 INT104624 Negative_regulation of Apoe 26 0.59 19.25 3.71 5.00
177 INT16165 Regulation of DMD 114 0.60 35.13 3.64 5.00
178 INT46621 Positive_regulation of Gene_expression of CSF1 17 0.47 10.53 3.59 5.00
179 INT40368 Positive_regulation of LRP5 5 0.49 3.19 3.51 5.00
180 INT116281 Negative_regulation of Gene_expression of Mmp13 15 0.41 9.96 3.41 5.00
181 INT171998 Binding of DMD 58 0.47 38.13 3.35 5.00
182 INT61259 Negative_regulation of Itgam 16 0.47 11.11 3.27 5.00
183 INT17750 Localization of MRXS5 15 0.56 6.65 3.1 5.00
184 INT91341 Negative_regulation of Gene_expression of BGLAP 17 0.55 4.91 3.02 5.00
185 INT301272 Positive_regulation of Clec5a 1 0.69 6.17 2.92 5.00
186 INT234717 Regulation of Cxcl1 10 0.41 6.14 2.9 5.00
187 INT569 Negative_regulation of C4a 13 0.42 9.48 2.85 5.00
188 INT93531 Negative_regulation of Gene_expression of Tnfsf11 15 0.43 7.74 2.84 5.00
189 INT170305 Regulation of Gene_expression of Mmp9 11 0.33 5.7 2.8 5.00
190 INT47770 Positive_regulation of Transcription of Fos 9 0.49 1.87 2.71 5.00
191 INT196870 Positive_regulation of Phosphorylation of Car2 6 0.26 3.43 2.63 5.00
192 INT61465 Gene_expression of Acp5 22 0.75 7.06 2.55 5.00
193 INT111528 Positive_regulation of Gene_expression of Nfatc1 5 0.67 3.24 2.52 5.00
194 INT262474 Gene_expression of Aqp6 26 0.77 2.08 2.49 5.00
195 INT194748 Positive_regulation of Nfatc1 16 0.64 5.07 2.44 5.00
196 INT144490 Regulation of Gene_expression of Tnfsf11 14 0.58 14.09 2.39 5.00
197 INT93532 Regulation of Tnfsf11 14 0.42 10.75 2.39 5.00
198 INT64777 Negative_regulation of COL5A2 32 0.38 17.4 2.28 5.00
199 INT158123 Negative_regulation of Gene_expression of COL5A2 19 0.46 15.27 2.23 5.00
200 INT224620 Positive_regulation of Gene_expression of Ctsk 13 0.68 8.35 2.21 5.00
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