D:Osteophyte

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Disease Term
Synonyms Bone Spur, Bone Spurs, OSTEOPHYTES, Spur Bone, Spurs Bone
Documents 816
Hot Single Events 126
Hot Interactions 5

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Osteophyte. They are ordered first by their relevance to Osteophyte and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT350169 Binding of DMD and MRI1 1 0.11 3.08 0.54 100.00
2 INT254242 TNF Positive_regulation of Gene_expression of DKK1 1 0.14 1.24 0.91 98.12
3 INT323773 Binding of Il6 and Lep 1 0.29 3.54 0.6 86.16
4 INT194859 IL1B Positive_regulation of Gene_expression of MMP13 2 0.52 0.86 0.33 85.64
5 INT171990 Binding of DMD and VDR 5 0.05 2.58 0.39 84.24
6 INT278944 ZEB1 Negative_regulation of IL1B 1 0.00 1.09 0.39 78.48
7 INT131185 PTH Positive_regulation of Gene_expression of IGF1 3 0.44 3.31 1.31 75.44
8 INT278960 ZEB1 Negative_regulation of MMP3 1 0.00 1.05 0.38 71.20
9 INT278943 ZEB1 Negative_regulation of Gene_expression of MMP3 1 0.00 1.05 0.38 71.20
10 INT303857 DDR1 Positive_regulation of IL8 1 0.05 1.5 0.42 70.36
11 INT303858 DDR1 Positive_regulation of CXCR2 1 0.11 1.5 0.42 70.16
12 INT203168 PTGER2 Negative_regulation of Gene_expression of ALOX5AP 1 0.03 2.4 1.18 69.12
13 INT309779 PTH Negative_regulation of Gene_expression of COL5A2 1 0.00 0.52 0.14 65.36
14 INT326974 BMP2 Positive_regulation of Gene_expression of COL2A1 1 0.07 0.27 0.11 60.56
15 INT131184 PTGER2 Positive_regulation of Gene_expression of IGF1 1 0.63 2.47 1.29 54.84
16 INT312106 EGR1 Regulation of Gene_expression of PTGES 1 0.31 1.06 0.64 50.16
17 INT350168 Binding of DMD and PROC 1 0.00 0.67 0 48.96
18 INT278948 LEP Positive_regulation of Gene_expression of PTGER2 1 0.09 4.04 2.69 38.04
19 INT278962 LEP Positive_regulation of CPOX 1 0.05 1.33 1 38.04
20 INT278958 LEP Positive_regulation of IL1B 1 0.33 1.91 0.74 34.16
21 INT194858 Binding of IL1B and SIGMAR1 1 0.01 0.55 0.3 33.12
22 INT203163 LTB4R Regulation of Gene_expression of ALOX5 1 0.00 0.98 0.41 31.92
23 INT309780 Binding of PTH and PTH1R 3 0.12 0.3 0.09 30.08
24 INT194860 BMPR2 Positive_regulation of IL1B 1 0.01 0.61 0.34 28.96
25 INT194865 Binding of SIGMAR1 and Positive_regulation of IL1B 1 0.01 0.62 0.35 25.84
26 INT194862 SIGMAR1 Positive_regulation of IL1B 1 0.01 0.62 0.35 25.84
27 INT312102 Binding of ALOX5 and ALOX5AP 1 0.10 0.65 0.36 15.60
28 INT64718 IL1B Positive_regulation of Gene_expression of IL6 15 0.59 9.37 4.48 5.00
29 INT130721 Binding of IL1B and IL1RN 6 0.05 5.29 2.85 5.00
30 INT278937 LEP Positive_regulation of Gene_expression of IL6 1 0.32 3.42 1.97 5.00
31 INT194863 Binding of IL1R1 and IL1RN 5 0.09 2.23 1.64 5.00
32 INT254243 Binding of HOMER1 and MRI1 1 0.03 1.99 1.57 5.00
33 INT311914 Il1 Negative_regulation of Gene_expression of Col2a1 1 0.01 1.94 1.23 5.00
34 INT194861 Binding of IL1B and IL1R1 2 0.01 1.55 1.2 5.00
35 INT247469 RCT Regulation of OAP 1 0.02 1.8 1.19 5.00
36 INT312097 ELANE Regulation of ALOX5 1 0.08 1.75 1.05 5.00
37 INT203178 IL18 Positive_regulation of Gene_expression of Lts1 1 0.01 1.98 1.02 5.00
38 INT278946 IL6 Regulation of Gene_expression of IL8 1 0.20 1.9 1 5.00
39 INT278940 LEP Positive_regulation of Gene_expression of IL8 1 0.34 1.68 0.96 5.00
40 INT351311 Has1 Regulation of Gene_expression of MMP3 1 0.11 1.15 0.95 5.00
41 INT203162 PTGER2 Regulation of Gene_expression of ALOX5AP 1 0.04 1.47 0.94 5.00
42 INT90387 ROS1 Positive_regulation of NFKB1 4 0.32 2.35 0.87 5.00
43 INT351323 Nts Regulation of Localization of Calca 1 0.01 0.6 0.85 5.00
44 INT265566 Binding of PDE4D and PTPN5 1 0.03 0.81 0.85 5.00
45 INT203164 PTGER2 Regulation of ALOX5 1 0.00 0.9 0.78 5.00
46 INT322201 Binding of OAP and SLC34A1 1 0.01 1.49 0.77 5.00
47 INT351322 Nts Regulation of Localization of Napa 1 0.01 0.56 0.77 5.00
48 INT203171 PTGER2 Negative_regulation of ALOX5 1 0.01 0.89 0.77 5.00
49 INT355704 Binding of Cia1 and Aia1 1 0.00 1.85 0.77 5.00
50 INT178576 CNTN2 Positive_regulation of DPYD 1 0.05 2.18 0.76 5.00
51 INT178581 CNTN2 Positive_regulation of PTHLH 1 0.24 2.16 0.75 5.00
52 INT178577 CNTN2 Positive_regulation of IL2RA 1 0.03 2.16 0.75 5.00
53 INT178579 CNTN2 Positive_regulation of IL6 1 0.07 2.17 0.75 5.00
54 INT178575 CNTN2 Positive_regulation of PTHLH Positive_regulation of Positive_regulation of PTHLH 1 0.26 2.16 0.75 5.00
55 INT170992 Binding of FN1 and MMRN1 3 0.01 2.13 0.73 5.00
56 INT312101 ELANE Regulation of ALOX5AP 1 0.21 1.11 0.73 5.00
57 INT278956 LEP Regulation of Gene_expression of IL8 1 0.30 1.11 0.69 5.00
58 INT278968 LEP Regulation of Gene_expression of IL6 1 0.29 1.11 0.69 5.00
59 INT278951 LEP Regulation of Gene_expression of PTGER2 1 0.07 1.11 0.69 5.00
60 INT278953 IL6 Regulation of Gene_expression of PTGER2 1 0.04 1.38 0.67 5.00
61 INT278965 LEP Positive_regulation of Gene_expression of NOS2 2 0.29 2.12 0.66 5.00
62 INT220148 Binding of IGF1 and IGFBP3 12 0.36 5.56 0.66 5.00
63 INT312105 ELANE Positive_regulation of Localization of PTGER2 4 0.03 1.3 0.64 5.00
64 INT188471 Binding of Gpi1 and Arhgap4 1 0.07 1.61 0.58 5.00
65 INT312118 ELANE Regulation of PTGES 1 0.22 0.92 0.49 5.00
66 INT312112 ELANE Regulation of Transcription of ALOX5 1 0.09 0.82 0.47 5.00
67 INT203177 Negative_regulation of CPOX Positive_regulation of Gene_expression of Lts1 1 0.00 0.72 0.46 5.00
68 INT307675 Binding of IL1R1 and SNRNP70 1 0.02 1.05 0.45 5.00
69 INT278950 MAPK8 Negative_regulation of Localization of EPHB2 1 0.25 0.47 0.43 5.00
70 INT278964 MAPK14 Negative_regulation of Localization of EPHB2 1 0.15 0.47 0.43 5.00
71 INT312123 ELANE Positive_regulation of ALOX5 1 0.09 0.74 0.4 5.00
72 INT312122 ELANE Positive_regulation of Protein_catabolism of COL2A1 1 0.05 0.65 0.39 5.00
73 INT312086 ELANE Positive_regulation of MMP13 1 0.13 0.64 0.39 5.00
74 INT203167 Gene_expression of PTGER2 Positive_regulation of Gene_expression of ALOX5AP 1 0.03 0.67 0.38 5.00
75 INT278957 JAK3 Positive_regulation of Gene_expression of IL8 1 0.28 0.67 0.38 5.00
76 INT278970 MAPK14 Positive_regulation of Gene_expression of IL8 1 0.11 0.66 0.37 5.00
77 INT278955 JAK3 Positive_regulation of Gene_expression of PRKCA 1 0.12 0.65 0.37 5.00
78 INT323774 Binding of Il6 and OPA6 1 0.01 0.85 0.37 5.00
79 INT278938 MAPK14 Positive_regulation of Gene_expression of PRKCA 1 0.05 0.65 0.37 5.00
80 INT278966 MAPK14 Positive_regulation of Gene_expression of LEP 1 0.16 0.62 0.36 5.00
81 INT278949 JAK3 Positive_regulation of Gene_expression of LEP 1 0.42 0.63 0.36 5.00
82 INT312124 EGR1 Regulation of Binding of PTGES 1 0.31 0.41 0.35 5.00
83 INT254344 Binding of Col2a1 and Ncoa5 1 0.00 0.98 0.35 5.00
84 INT203166 Negative_regulation of CPOX Positive_regulation of Gene_expression of LTB4R 1 0.00 0.65 0.34 5.00
85 INT312119 ELANE Positive_regulation of Gene_expression of PTGES 1 0.18 0.74 0.33 5.00
86 INT312099 ELANE Positive_regulation of Gene_expression of PTGER2 1 0.02 0.64 0.32 5.00
87 INT312085 ELANE Regulation of Regulation of ALOX5 1 0.09 0.64 0.32 5.00
88 INT278942 LEP Regulation of IL6 1 0.29 0.61 0.31 5.00
89 INT354790 MMP3 Negative_regulation of Gene_expression of OSM 1 0.00 0.27 0.31 5.00
90 INT278939 LEP Regulation of IL8 1 0.13 0.61 0.31 5.00
91 INT323855 IL6 Positive_regulation of Positive_regulation of TNF 1 0.04 1.03 0.31 5.00
92 INT278969 LEP Regulation of PTGER2 1 0.03 0.6 0.31 5.00
93 INT278961 IL6 Regulation of Gene_expression of LEP 1 0.29 0.89 0.3 5.00
94 INT203169 CPOX Regulation of Gene_expression of PTGER2 2 0.00 0.48 0.29 5.00
95 INT203170 Negative_regulation of CPOX Positive_regulation of ALOX5 1 0.01 0.53 0.29 5.00
96 INT182771 ROS1 Positive_regulation of NFKB1 Positive_regulation of CRP 1 0.00 3.83 0.28 5.00
97 INT178578 Binding of PTHLH and CALCRL 1 0.01 0.68 0.27 5.00
98 INT278971 IL1B Positive_regulation of Gene_expression of NOS2 1 0.14 0.79 0.27 5.00
99 INT323926 MRM1 Positive_regulation of MRI1 1 0.04 0.44 0.26 5.00
100 INT311918 Insrr Negative_regulation of Tgfbr1 1 0.00 0.87 0.26 5.00
101 INT311902 Acvrl1 Negative_regulation of Tgfbr1 1 0.13 0.87 0.26 5.00
102 INT278952 MST1 Regulation of Gene_expression of PTGER2 1 0.00 0.41 0.25 5.00
103 INT102621 IL6 Regulation of Gene_expression of CPOX 1 0.13 0.78 0.25 5.00
104 INT278941 MST1 Regulation of Gene_expression of IL8 1 0.01 0.4 0.25 5.00
105 INT312115 ELANE Positive_regulation of Transcription of PTGES 1 0.25 0.53 0.25 5.00
106 INT311900 Acvrl1 Negative_regulation of Insrr 1 0.00 0.86 0.25 5.00
107 INT278954 MST1 Regulation of Gene_expression of NOS2 1 0.01 0.41 0.25 5.00
108 INT203165 Binding of IL10 and PTGER2 1 0.01 0.5 0.25 5.00
109 INT278967 MST1 Regulation of Gene_expression of CPOX 1 0.00 0.41 0.25 5.00
110 INT278945 NOS2 Regulation of Gene_expression of CPOX 1 0.02 0.41 0.25 5.00
111 INT278963 IL6 Regulation of Gene_expression of NOS2 1 0.12 0.41 0.25 5.00
112 INT239087 Binding of SST and Negative_regulation of Localization of GH1 1 0.19 0.36 0.24 5.00
113 INT311911 Tgfbr1 Positive_regulation of Gene_expression of Mmp13 1 0.10 0.55 0.23 5.00
114 INT311908 Acvrl1 Positive_regulation of Gene_expression of Mmp13 1 0.10 0.55 0.23 5.00
115 INT203176 PTGER2 Regulation of Gene_expression of Lts1 1 0.00 0.37 0.23 5.00
116 INT311923 OAP Positive_regulation of Gtf3a 1 0.00 0.7 0.19 5.00
117 INT312091 ALOX5AP Regulation of Transcription of ALOX5 1 0.13 0.37 0.18 5.00
118 INT312090 EGR1 Regulation of Positive_regulation of PTGES 1 0.42 0.21 0.18 5.00
119 INT312109 ELANE Positive_regulation of EGR1 1 0.15 0.23 0.16 5.00
120 INT188470 Binding of Gpi1 and Il27ra 1 0.00 0.86 0.16 5.00
121 INT312100 ELANE Positive_regulation of Binding of EGR1 1 0.16 0.23 0.16 5.00
122 INT312089 LTB4R Positive_regulation of ALOX5AP 1 0.01 0.32 0.16 5.00
123 INT278947 PTGER2 Regulation of Gene_expression of IL8 1 0.04 0.32 0.16 5.00
124 INT312095 LTB4R Positive_regulation of ALOX5 1 0.01 0.32 0.16 5.00
125 INT312111 ELANE Regulation of Transcription of PTGES 1 0.22 0.23 0.16 5.00
126 INT312126 ELANE Positive_regulation of ALOX5AP 1 0.20 0.25 0.15 5.00
127 INT312092 ELANE Positive_regulation of Gene_expression of EGR1 1 0.19 0.21 0.15 5.00
128 INT264868 Binding of COL1A2 and GOPC 1 0.02 0.3 0.15 5.00
129 INT182772 ROS1 Positive_regulation of NFKB1 Positive_regulation of IL1B 1 0.00 1.89 0.14 5.00
130 INT182773 ROS1 Positive_regulation of NFKB1 Positive_regulation of IL6 1 0.00 1.9 0.14 5.00
131 INT182780 NFKB1 Positive_regulation of IL1B 1 0.00 1.8 0.14 5.00
132 INT182782 NFKB1 Positive_regulation of IL6 1 0.00 1.8 0.14 5.00
133 INT312096 ELANE Positive_regulation of Transcription of ALOX5 1 0.06 0.27 0.13 5.00
134 INT311905 Binding of Runx2 and Smad1 1 0.12 0.46 0.13 5.00
135 INT311912 Gene_expression of Smad1 Positive_regulation of Gene_expression of Mmp13 1 0.08 0.51 0.12 5.00
136 INT312218 INPP5K Positive_regulation of Protein_catabolism of IGFBP3 1 0.17 0.39 0.11 5.00
137 INT312212 Binding of ADAM12 and INPP5K 1 0.16 0.46 0.11 5.00
138 INT312094 ELANE Positive_regulation of PTGES 1 0.29 0.34 0.11 5.00
139 INT312116 Negative_regulation of PTGER2 Regulation of Gene_expression of ALOX5AP 1 0.04 0.2 0.1 5.00
140 INT312121 Negative_regulation of PTGER2 Regulation of Gene_expression of ALOX5 1 0.02 0.2 0.1 5.00
141 INT295005 Binding of TNFRSF11A and Tnfsf11 3 0.20 2.02 0.09 5.00
142 INT312103 ELANE Regulation of Gene_expression of ALOX5 1 0.06 0.15 0.08 5.00
143 INT311917 Gene_expression of Tgfbr1 Positive_regulation of Gene_expression of Mmp13 1 0.10 0.31 0.08 5.00
144 INT245732 Binding of COL9A2 and DISC1 1 0.07 1.34 0.08 5.00
145 INT312093 ELANE Regulation of Gene_expression of ALOX5AP 1 0.13 0.15 0.08 5.00
146 INT334061 Negative_regulation of Binding of TNFRSF11A and Tnfsf11 1 0.01 0.52 0.08 5.00
147 INT312219 Binding of IGF1 and IGFBP5 1 0.02 0.13 0.08 5.00
148 INT312087 PTGER2 Regulation of Gene_expression of ALOX5 1 0.01 0.13 0.07 5.00
149 INT312113 ELANE Positive_regulation of Gene_expression of ALOX5AP 1 0.23 0.14 0.07 5.00
150 INT311915 Tgfbr1 Negative_regulation of Gene_expression of Mmp13 1 0.09 0.27 0.06 5.00
151 INT311903 Acvrl1 Negative_regulation of Gene_expression of Mmp13 1 0.09 0.27 0.06 5.00
152 INT311916 Smad3 Negative_regulation of Gene_expression of Mmp13 1 0.12 0.27 0.06 5.00
153 INT311910 Acvrl1 Positive_regulation of Phosphorylation of Smad1 1 0.12 0.24 0.06 5.00
154 INT311906 Binding of Smad4 and Insrr 1 0.00 0.18 0.06 5.00
155 INT312228 INPP5K Regulation of TGFB1 1 0.06 0.08 0.05 5.00
156 INT220081 Binding of COL1A1 and MMRN1 1 0.00 0.36 0.05 5.00
157 INT312226 INPP5K Positive_regulation of IGFBP5 1 0.12 0.07 0.05 5.00
158 INT182775 Binding of PTH and ROS1 1 0.04 1.73 0.04 5.00
159 INT312110 ELANE Positive_regulation of Gene_expression of ALOX5 1 0.09 0.07 0.04 5.00
160 INT312104 Binding of ALOX5 and PTGES 1 0.13 0.14 0.04 5.00
161 INT312117 Negative_regulation of ELANE Positive_regulation of ALOX5AP 1 0.17 0.08 0.04 5.00
162 INT311909 Gene_expression of Smad6 Negative_regulation of Gene_expression of Col10a1 1 0.02 0.54 0.04 5.00
163 INT311904 Smad2 Positive_regulation of Gene_expression of Smad1 1 0.13 0.44 0.03 5.00
164 INT312125 Binding of ELANE and PTGES 1 0.13 0.07 0.03 5.00
165 INT312076 PTGER2 Regulation of ELANE Regulation of ALOX5 1 0.01 0.06 0.03 5.00
166 INT312077 PTGER2 Regulation of ELANE Regulation of ALOX5AP 1 0.02 0.06 0.03 5.00
167 INT312224 INPP5K Regulation of Negative_regulation of COL1A1 1 0.08 0 0 5.00
168 INT312221 Binding of TGFB1 and INPP5K 1 0.09 0 0 5.00
169 INT182784 IGF1 Positive_regulation of Gene_expression of INS 1 0.02 1.87 0 5.00
170 INT197761 Binding of KRT5 and C4a 1 0.02 2.29 0 5.00
171 INT312220 IL4 Positive_regulation of Regulation of INPP5K 1 0.05 0.24 0 5.00
172 INT312222 IFNA1 Positive_regulation of Regulation of INPP5K 1 0.05 0.24 0 5.00
173 INT245726 SOX9 Regulation of SGCG 1 0.00 0.29 0 5.00
174 INT182804 Binding of ETV3 and T2DM 1 0.10 2.62 0 5.00
175 INT245731 Binding of COL5A2 and DISC1 1 0.01 0.42 0 5.00
176 INT312230 INPP5K Regulation of Gene_expression of COL2A1 1 0.06 0 0 5.00
177 INT312225 Positive_regulation of INPP5K Positive_regulation of CD44 1 0.15 0.1 0 5.00
178 INT197762 Binding of KRT5 and Cpe 1 0.19 1.14 0 5.00
179 INT245727 Binding of SUGT1 and DISC1 1 0.00 1.57 0 5.00
180 INT197760 Binding of C4a and Cpe 1 0.01 1.14 0 5.00
181 INT312107 ELANE Positive_regulation of Gene_expression of COX18 1 0.04 0 0 5.00
182 INT171991 Binding of DMD and ERAL1 1 0.01 0.54 0 5.00
183 INT312214 INPP5K Regulation of Gene_expression of COL1A1 1 0.08 0 0 5.00
184 INT245733 Binding of VDR and DISC1 1 0.03 0.75 0 5.00
185 INT245730 RENBP Regulation of DISC1 1 0.01 0.58 0 5.00
186 INT312114 EGR1 Positive_regulation of Positive_regulation of PTGES 1 0.32 0 0 5.00
187 INT182778 IGF1 Positive_regulation of Gene_expression of ETV3 1 0.03 1.89 0 5.00
188 INT312223 INPP5K Negative_regulation of Gene_expression of COL10A1 1 0.04 0.1 0 5.00
189 INT312227 INPP5K Regulation of Negative_regulation of COL2A1 1 0.06 0 0 5.00
190 INT245734 Binding of COL9A1 and COL9A2 1 0.26 0.52 0 5.00
191 INT312120 ELANE Regulation of Localization of PTGER2 1 0.03 0 0 5.00
192 INT345060 Binding of SGCG and C2 1 0.00 0.93 0 5.00
193 INT312215 INPP5K Negative_regulation of COL10A1 1 0.03 0.1 0 5.00
194 INT312098 ELANE Regulation of Gene_expression of COX18 1 0.05 0 0 5.00
195 INT182774 Binding of ETV3 and SAE1 1 0.00 1.17 0 5.00
196 INT182783 INS Positive_regulation of Gene_expression of ETV3 1 0.01 1.89 0 5.00
197 INT312229 INPP5K Positive_regulation of CD44 1 0.15 0.1 0 5.00
198 INT182777 IAPP Positive_regulation of Gene_expression of ETV3 1 0.06 1.88 0 5.00
199 INT312216 INPP5K Negative_regulation of Gene_expression of RUNX2 1 0.15 0.1 0 5.00
200 INT245728 Binding of TRNAP2 and DISC1 1 0.03 0.54 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Osteophyte. They are ordered first by their pain relevance and then by number of times they were reported in Osteophyte. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT134694 Binding of CYP27A1 10 0.47 5.61 3.56 100.00
2 INT177455 Binding of Cia1 4 0.11 6.76 2.24 100.00
3 INT63816 Binding of Aia1 20 0.23 22.28 4.13 100.00
4 INT171666 Regulation of GOPC 117 0.39 40.41 15.47 100.00
5 INT82829 Gene_expression of COMP 104 0.78 57 9.81 99.96
6 INT301482 Localization of CMC1 1 0.73 1.07 0.07 99.96
7 INT101483 Gene_expression of Lep 159 0.78 104.77 25.12 99.84
8 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 99.84
9 INT111153 Positive_regulation of Dkk1 13 0.68 10.56 2.58 99.80
10 INT344976 Positive_regulation of Negative_regulation of Dkk1 1 0.49 1.13 0.33 99.80
11 INT92632 Gene_expression of Vsig2 48 0.50 19.93 3.04 99.72
12 INT147549 Gene_expression of Sha 3 0.52 2.19 0.62 99.72
13 INT214699 Gene_expression of CMC1 1 0.65 2.43 0.77 99.60
14 INT70265 Regulation of MRI1 42 0.39 30.95 14.18 99.44
15 INT65391 Positive_regulation of Vsig2 13 0.32 5.71 1.49 99.34
16 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 99.16
17 INT68683 Regulation of Gene_expression of VEGFA 143 0.62 104.19 20.14 99.16
18 INT126580 Gene_expression of sal 16 0.50 5.52 0.82 99.12
19 INT171998 Binding of DMD 58 0.47 38.13 3.35 99.10
20 INT180149 Positive_regulation of SRA1 7 0.40 2.65 0.65 99.00
21 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 98.92
22 INT20552 Negative_regulation of Gene_expression of COL2A1 29 0.56 11.92 4.81 98.92
23 INT139475 Negative_regulation of DKK1 14 0.52 9.2 1.76 98.92
24 INT111156 Negative_regulation of Dkk1 21 0.58 20.08 4.27 98.68
25 INT6580 Negative_regulation of Ptgs1 929 0.59 381.53 376.26 98.68
26 INT346117 Regulation of sal 1 0.26 0.19 0 98.56
27 INT11659 Gene_expression of COL2A1 164 0.78 78.49 22.58 98.36
28 INT130731 Protein_catabolism of COL2A1 47 0.96 21.86 9.28 98.36
29 INT9657 Positive_regulation of Gene_expression of Il6 237 0.70 180.45 63.6 98.28
30 INT301479 Positive_regulation of Gene_expression of Vsig2 2 0.32 2.78 0.08 98.24
31 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 98.16
32 INT188255 Gene_expression of DKK1 19 0.60 12.69 2.39 98.12
33 INT16166 Positive_regulation of DMD 348 0.67 133.22 15.06 98.06
34 INT180497 Binding of MRI1 45 0.42 28.35 14.77 97.92
35 INT245741 Negative_regulation of Gene_expression of DISC1 2 0.17 1.29 0.34 97.88
36 INT254330 Regulation of Msc 10 0.16 7.59 1.46 97.80
37 INT245736 Gene_expression of DISC1 13 0.61 7.65 1.33 97.48
38 INT119700 Gene_expression of VDR 88 0.75 65.33 11.5 97.36
39 INT101481 Positive_regulation of Lep 81 0.69 62.59 9.95 96.80
40 INT89116 Regulation of Positive_regulation of VEGFA 8 0.43 6.62 1.5 96.72
41 INT156850 Binding of VDR 40 0.47 24.86 4.87 96.68
42 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 96.64
43 INT79061 Positive_regulation of NOS2 92 0.65 58.89 23.96 96.64
44 INT50843 Positive_regulation of Phex 5 0.43 1.38 1.31 96.52
45 INT1760 Gene_expression of PTGER2 524 0.57 226.94 96.4 96.36
46 INT51685 Gene_expression of LTB4R 87 0.58 68.69 31.72 96.36
47 INT346118 Binding of Gdf5 1 0.03 1.43 0.12 96.24
48 INT62124 Gene_expression of NOS1 444 0.78 218.08 114.85 96.24
49 INT85809 Gene_expression of BMP2 46 0.78 9.91 3.05 96.24
50 INT6488 Gene_expression of Tnf 484 0.78 339.61 191.58 96.04
51 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 95.76
52 INT573 Negative_regulation of C3 60 0.59 41.37 7.78 95.68
53 INT17442 Gene_expression of ALOX5 110 0.75 51.55 18.29 95.32
54 INT79060 Gene_expression of NOS2 116 0.78 69.25 34.84 95.32
55 INT11729 Regulation of IGF1 71 0.61 44.58 9.71 94.40
56 INT5010 Gene_expression of Calca 197 0.78 85.76 118.75 94.36
57 INT328235 Positive_regulation of PRCD 1 0.28 1.61 0.68 94.08
58 INT117232 Localization of COL2A1 11 0.72 7.34 1.3 93.88
59 INT28317 Gene_expression of NXT1 12 0.14 4.57 1.66 93.80
60 INT79299 Negative_regulation of NXT1 16 0.32 8.27 3.78 93.80
61 INT53184 Negative_regulation of CYP27A1 46 0.57 16.04 5.28 93.40
62 INT19132 Gene_expression of CYP27A1 83 0.75 34.31 10.17 93.40
63 INT207366 Negative_regulation of Gene_expression of CYP27A1 11 0.44 4.82 2.67 93.40
64 INT165337 Regulation of Dkk1 3 0.44 2.16 0.83 93.36
65 INT14740 Gene_expression of TGFB1 272 0.78 168.48 60.18 93.28
66 INT48235 Negative_regulation of NPEPPS 72 0.46 44.54 25.03 93.28
67 INT14733 Positive_regulation of Gene_expression of TGFB1 71 0.69 49.89 22.2 93.28
68 INT2144 Localization of COL7A1 36 0.74 20.92 4.67 92.56
69 INT202606 Regulation of PTPN5 1 0.26 3.92 3.04 92.28
70 INT344975 Regulation of Gene_expression of Dkk1 1 0.44 3.44 0.73 91.80
71 INT19131 Localization of CYP27A1 14 0.80 8.19 2.15 91.76
72 INT64777 Negative_regulation of COL5A2 32 0.38 17.4 2.28 91.64
73 INT129883 Gene_expression of Dkk1 56 0.77 45.42 12.52 91.20
74 INT9655 Regulation of Il6 98 0.62 70.92 31.95 90.84
75 INT102935 Regulation of Lep 31 0.60 18.47 5.24 90.84
76 INT214115 Regulation of Gene_expression of Lep 9 0.61 7.37 1.44 90.84
77 INT130739 Binding of Col1a2 2 0.35 2.38 0.34 90.72
78 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 90.72
79 INT245743 Positive_regulation of Gene_expression of DISC1 1 0.09 0.72 0.07 90.40
80 INT245760 Regulation of Gene_expression of DISC1 1 0.08 0.72 0.07 90.40
81 INT323929 Regulation of Localization of MRM1 1 0.12 0.41 0.1 89.88
82 INT1765 Positive_regulation of Gene_expression of PTGER2 140 0.51 68.68 27 89.64
83 INT62290 Positive_regulation of Gene_expression of PTGES2 5 0.28 3.14 1.88 89.64
84 INT323930 Localization of MRM1 1 0.21 0.4 0.1 89.40
85 INT231737 Localization of OAP 5 0.50 7.4 2.63 89.20
86 INT62291 Gene_expression of PTGES2 14 0.68 8.34 4.75 89.08
87 INT10834 Binding of IL8 65 0.48 41.66 16.53 88.68
88 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 88.40
89 INT156827 Localization of MRI1 25 0.65 16.06 8.33 88.36
90 INT109699 Regulation of BMP2 5 0.43 2.21 0.23 88.32
91 INT195414 Gene_expression of ALOX5AP 65 0.72 31.22 15.25 88.16
92 INT44254 Regulation of Gene_expression of ALOX5 12 0.43 7.06 3.65 88.16
93 INT140874 Binding of MNX1 4 0.36 0.85 0.69 87.92
94 INT301480 Positive_regulation of Sha 3 0.23 1.83 0.3 87.36
95 INT82828 Positive_regulation of COMP 45 0.61 35.12 6.2 87.04
96 INT141148 Gene_expression of BMP7 24 0.71 14.34 3.44 86.56
97 INT173808 Positive_regulation of CYP27A1 35 0.68 23.7 7.87 86.44
98 INT233812 Gene_expression of PTH1R 32 0.77 18.15 6.15 86.36
99 INT236824 Negative_regulation of Gene_expression of PTH1R 10 0.58 9.3 3.42 86.36
100 INT233816 Negative_regulation of PTH1R 2 0.58 4.08 1.07 86.36
101 INT1761 Positive_regulation of PTGER2 135 0.49 90.17 26.26 86.32
102 INT148686 Localization of C6 5 0.31 4.27 0.64 86.24
103 INT129960 Negative_regulation of Gene_expression of MMP13 19 0.53 7.17 3.55 86.20
104 INT91338 Binding of Lep 31 0.48 26.86 5.39 86.16
105 INT54763 Binding of Il6 82 0.48 63.27 12.89 86.16
106 INT94953 Negative_regulation of Mapk14 156 0.59 104.77 91.51 86.04
107 INT5008 Localization of Calca 204 0.81 80.35 125.16 86.00
108 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 85.64
109 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 85.60
110 INT28950 Positive_regulation of Gene_expression of IGF1 99 0.69 46.9 16.47 85.60
111 INT129962 Positive_regulation of Gene_expression of MMP13 41 0.65 20.74 8.54 85.44
112 INT129956 Gene_expression of MMP13 145 0.72 60.48 26.98 85.12
113 INT20425 Localization of Cpe 23 0.81 5.18 9.14 85.00
114 INT124069 Localization of Ntrk1 9 0.59 3.32 1.13 84.44
115 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 83.88
116 INT39153 Positive_regulation of PTGS2 182 0.70 96.16 60.6 83.84
117 INT170855 Negative_regulation of GOPC 188 0.38 70.92 15.41 82.64
118 INT202008 Binding of OPA6 2 0.35 1.98 1.11 82.64
119 INT49750 Negative_regulation of CPOX 735 0.58 360.06 274.19 82.60
120 INT187133 Protein_catabolism of TIMP1 19 0.73 11.3 5.51 82.52
121 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 82.40
122 INT73234 Positive_regulation of Lbp 13 0.69 12.55 8.57 81.76
123 INT126743 Positive_regulation of Gene_expression of LEP 61 0.66 50.02 11.17 81.68
124 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 81.40
125 INT7180 Negative_regulation of Trib3 180 0.51 68.48 88.01 80.72
126 INT107691 Gene_expression of Star 9 0.68 5.73 1.32 80.68
127 INT49437 Gene_expression of OAP 25 0.54 20.12 7.34 79.88
128 INT99070 Gene_expression of Mapk14 147 0.78 103.99 79.59 79.84
129 INT202138 Positive_regulation of Gene_expression of VIT 1 0.10 0.9 0.37 79.84
130 INT10536 Gene_expression of Trib3 67 0.66 27.08 21.58 79.68
131 INT170987 Transcription of ALOX5 4 0.69 2.71 1.41 79.32
132 INT6515 Gene_expression of BGLAP 110 0.75 45.13 10.81 79.04
133 INT6513 Positive_regulation of Gene_expression of BGLAP 24 0.67 11.69 3.96 79.04
134 INT195060 Gene_expression of ALPL 9 0.73 4.82 1.3 79.04
135 INT6516 Positive_regulation of BGLAP 45 0.67 26.61 9.9 78.64
136 INT17881 Gene_expression of LEP 278 0.78 221.61 48.31 78.56
137 INT28642 Gene_expression of CXCR2 60 0.78 38.69 18.11 78.16
138 INT181316 Positive_regulation of ALPL 5 0.65 1.65 1.6 78.00
139 INT25610 Positive_regulation of Gene_expression of Il1 136 0.67 104.43 43.86 77.92
140 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 77.76
141 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 77.76
142 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 77.76
143 INT102638 Regulation of VDR 21 0.44 9.92 2.54 77.68
144 INT202137 Gene_expression of VIT 1 0.12 0.89 0.37 77.68
145 INT194876 Negative_regulation of Gene_expression of CTSK 1 0.03 0.75 0.23 77.48
146 INT174054 Positive_regulation of Gene_expression of Lep 25 0.69 21.3 3.72 77.16
147 INT77855 Gene_expression of Pain1 55 0.75 67.42 54.1 77.16
148 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 77.08
149 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85 77.00
150 INT59080 Negative_regulation of Gene_expression of PTGS2 55 0.58 22.92 12.39 77.00
151 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98 76.96
152 INT91527 Gene_expression of CTSK 38 0.78 22.21 7.42 76.96
153 INT336876 Negative_regulation of FRZB 2 0.08 3.21 0.66 76.56
154 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51 76.44
155 INT55135 Positive_regulation of Gene_expression of PTGS2 137 0.70 80.32 38.46 76.44
156 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 76.40
157 INT125080 Positive_regulation of Positive_regulation of TP53 21 0.58 16.16 1.98 76.40
158 INT220088 Positive_regulation of Positive_regulation of CDKN2A 4 0.49 4.04 0.44 76.40
159 INT14731 Positive_regulation of TGFB1 78 0.67 52.57 22.23 76.08
160 INT12082 Localization of IL6 365 0.81 241.78 105.78 75.96
161 INT65356 Localization of LEP 46 0.79 41.17 5.43 75.96
162 INT264881 Localization of CXCL13 4 0.42 9.52 1.85 75.96
163 INT245089 Localization of CXCL12 8 0.65 10.17 1.28 75.96
164 INT86437 Binding of IL6 154 0.48 121.22 29.3 75.64
165 INT75907 Binding of LEP 53 0.46 46.65 8.44 75.64
166 INT121661 Binding of CXCL12 25 0.37 11.27 3.82 75.64
167 INT182238 Binding of CXCL13 5 0.33 5.32 2.37 75.64
168 INT62958 Positive_regulation of CXCR2 14 0.59 8.61 4.92 75.36
169 INT17938 Binding of Cpe 28 0.48 11.17 13.62 74.88
170 INT207426 Gene_expression of COL10A1 27 0.65 12.02 3.85 74.40
171 INT9196 Gene_expression of PTGS1 215 0.77 96.99 60.5 74.40
172 INT95369 Positive_regulation of Gene_expression of NOS2 36 0.55 25.09 11.37 74.40
173 INT207429 Positive_regulation of Gene_expression of COL10A1 8 0.42 4.16 1.34 74.40
174 INT25607 Binding of Il1 82 0.47 64.4 23.9 74.28
175 INT170333 Binding of IFN1@ 68 0.47 49.01 9.72 74.28
176 INT158124 Gene_expression of COL5A2 136 0.69 72.3 12.44 74.24
177 INT84765 Positive_regulation of Mc1r 24 0.70 5.95 8.01 74.20
178 INT162258 Negative_regulation of Gene_expression of COMP 35 0.58 19.14 3.55 74.08
179 INT275345 Positive_regulation of sal 2 0.40 0.63 0.03 73.96
180 INT133508 Positive_regulation of TKTL1 8 0.60 6.37 4.8 73.56
181 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71 73.56
182 INT89794 Positive_regulation of CDKN2A 58 0.67 50.18 5.38 73.40
183 INT350378 Localization of Lrba 1 0.64 1.09 0.29 73.36
184 INT350379 Positive_regulation of Lrba 1 0.40 1.09 0.29 73.36
185 INT166707 Protein_catabolism of Col7a1 24 0.74 20.47 6.39 73.28
186 INT166708 Negative_regulation of Protein_catabolism of Col7a1 2 0.32 2.62 0.92 73.28
187 INT63419 Gene_expression of PTGES 109 0.77 40.83 23.67 72.72
188 INT244300 Localization of PTH1R 2 0.74 2.03 0.67 72.32
189 INT48232 Gene_expression of MMP1 245 0.78 96.31 57.72 71.76
190 INT69322 Negative_regulation of MAPK14 70 0.54 42.92 22.71 71.36
191 INT194875 Regulation of Negative_regulation of MAPK14 1 0.04 2.39 0.91 71.36
192 INT50970 Positive_regulation of Ntrk1 51 0.57 29.38 22.83 71.20
193 INT29496 Gene_expression of MMP3 136 0.75 49.49 41.78 71.20
194 INT88545 Localization of MMRN1 21 0.78 16.67 4.01 71.12
195 INT56860 Gene_expression of Ugcg 17 0.17 12.39 2.03 71.12
196 INT147517 Negative_regulation of Gene_expression of Ppara 12 0.37 3.46 2.55 71.04
197 INT88544 Gene_expression of MMRN1 102 0.75 68.8 14.55 70.72
198 INT61117 Gene_expression of Ppara 158 0.68 69.3 15.98 70.48
199 INT287241 Positive_regulation of BMP7 10 0.43 2.68 1.38 70.24
200 INT125066 Negative_regulation of HDAC4 56 0.49 41.55 5.42 68.96
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